SULT2B1

Summary

Gene Symbol: SULT2B1
Description: sulfotransferase family 2B member 1
Alias: ARCI14, HSST2, sulfotransferase family cytosolic 2B member 1, ST2B1, alcohol sulfotransferase, hydroxysteroid sulfotransferase 2, hydroxysteroid sulfotransferase SULT2B1a, sulfotransferase 2B1, sulfotransferase family, cytosolic, 2B, member 1
Species: human
Products:     SULT2B1

Top Publications

  1. Glatt H. Sulfotransferases in the bioactivation of xenobiotics. Chem Biol Interact. 2000;129:141-70 pubmed
    ..SULT-mediated reactivation may even occur if another initial reactive species, e.g. an epoxide, has reacted with water. ..
  2. He D, Meloche C, Dumas N, Frost A, Falany C. Different subcellular localization of sulphotransferase 2B1b in human placenta and prostate. Biochem J. 2004;379:533-40 pubmed
    ..The SULT2B1 isoforms are highly selective for the sulphation of 3beta-hydroxysteroids...
  3. Bai Q, Xu L, Kakiyama G, Runge Morris M, Hylemon P, Yin L, et al. Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells. Atherosclerosis. 2011;214:350-6 pubmed publisher
    ..Our data indicate that sulfation of 25HC by SULT2B1b plays an important role in the maintenance of intracellular lipid homeostasis via the LXR/SREBP-1c signaling pathway in HAECs. ..
  4. Dumas N, He D, Frost A, Falany C. Sulfotransferase 2B1b in human breast: differences in subcellular localization in African American and Caucasian women. J Steroid Biochem Mol Biol. 2008;111:171-7 pubmed publisher
    ..Nuclei isolation and immunoblot analysis of both BC tissue and human T-47D breast adenocarcinoma cells demonstrated that SULT2B1b is present in nuclei and cytoplasm. ..
  5. He D, Falany C. Inhibition of SULT2B1b expression alters effects of 3beta-hydroxysteroids on cell proliferation and steroid hormone receptor expression in human LNCaP prostate cancer cells. Prostate. 2007;67:1318-29 pubmed
    ..Inhibition of SULT2B1b increased cell proliferation and ER-beta repression after treatment with physiological levels of DHEA and Delta(5)-Adiol indicating that SULT2B1b has an inhibitory effect on DHEA and Delta(5)-Adiol activity. ..
  6. Lee K, Fuda H, Lee Y, Negishi M, Strott C, Pedersen L. Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms. J Biol Chem. 2003;278:44593-9 pubmed
    The gene for human hydroxysteroid sulfotransferase (SULT2B1) encodes two peptides, SULT2B1a and SULT2B1b, that differ only at their amino termini...
  7. Gu S, MATTA J, Davini W, Dawe G, Lord B, Bredt D. α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components. Cell Rep. 2019;26:866-874.e3 pubmed publisher
    ..proteins, β-anchoring and -regulatory protein (BARP), lysosomal-associated membrane protein 5 (LAMP5), and SULT2B1, that complement the nACh receptor chaperone NACHO to reconstitute α6β2β3 channel function...
  8. Ye H, Ha M, Yang M, Yue P, Xie Z, Liu C. Di2-ethylhexyl phthalate disrupts thyroid hormone homeostasis through activating the Ras/Akt/TRHr pathway and inducing hepatic enzymes. Sci Rep. 2017;7:40153 pubmed publisher
    ..Additionally, hepatic enzymes, including Ugt1a1, CYP2b1, Sult1e1, and Sult2b1, were significantly induced after DEHP exposure...
  9. Fang J, Loukotková L, Chitranshi P, Gamboa da Costa G, Beland F. Effects of human sulfotransferases on the cytotoxicity of 12-hydroxynevirapine. Biochem Pharmacol. 2018;155:455-467 pubmed publisher
    ..Of the 12 human SULTs, no detectable 12-sulfoxynevirapine was observed with SULT1A3, SULT1C2, SULT1C3, SULT2B1, SULT4A1, or SULT6B1...

More Information

Publications51

  1. Gao H, Luo X, Chen X, Wang J. Identification of key genes affecting disease free survival time of pediatric acute lymphoblastic leukemia based on bioinformatic analysis. Blood Cells Mol Dis. 2015;54:38-43 pubmed publisher
    ..For the 75 key genes, 27 disease risk sub-pathways were identified, and HK3, HNMT, SULT2B1, KYNU, and PTGS2 were the significant key genes which were enriched in these sub-pathways...
  2. Hyland P, Freedman N, Hu N, Tang Z, Wang L, Wang C, et al. Genetic variants in sex hormone metabolic pathway genes and risk of esophageal squamous cell carcinoma. Carcinogenesis. 2013;34:1062-8 pubmed publisher
    ..15 and estrogen removal: P = 0.19) with risk of ESCC. However, six individual genes (including SULT2B1, CYP1B1, CYP3A7, CYP3A5, SHBG and CYP11A1) were significantly associated with ESCC risk (P < 0.05)...
  3. Dubaisi S, Barrett K, Fang H, Guzman Lepe J, Soto Gutierrez A, Kocarek T, et al. Regulation of Cytosolic Sulfotransferases in Models of Human Hepatocyte Development. Drug Metab Dispos. 2018;46:1146-1156 pubmed publisher
    ..By contrast, SULT2A1 mRNA levels increased during differentiation, whereas SULT1A1 and SULT2B1 mRNA levels remained relatively constant...
  4. Sakurai T, Uruno T, Sugiura Y, Tatsuguchi T, Yamamura K, Ushijima M, et al. Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye. Sci Signal. 2018;11: pubmed publisher
    ..By genetically inactivating Sult2b1, we showed that the lack of CS in mice augmented ultraviolet- and antigen-induced ocular surface inflammation,..
  5. Li S, Xie L, Du M, Xu K, Zhu L, Chu H, et al. Association study of genetic variants in estrogen metabolic pathway genes and colorectal cancer risk and survival. Arch Toxicol. 2018;92:1991-1999 pubmed publisher
    ..Colorectal cancer risk and rs3760806 in SULT2B1 were significantly associated in both genders [male: OR = 1.38 (1.15-1.66); female: OR = 1.38 (1.13-1...
  6. Hevir Kene N, Rižner T. The endometrial cancer cell lines Ishikawa and HEC-1A, and the control cell line HIEEC, differ in expression of estrogen biosynthetic and metabolic genes, and in androstenedione and estrone-sulfate metabolism. Chem Biol Interact. 2015;234:309-19 pubmed publisher
    ..and metabolic enzymes, these cells showed statistically significant different gene expression profiles for SULT2B1, HSD3B2, CYP19A1, AKR1C3, HSD17B1, HSD17B7, HSD17B12, CYP1B1, CYP3A5, COMT, SULT1A1, GSTP1 and NQO2...
  7. Zimmer B, Tenbusch L, Klymiuk M, Dezhkam Y, Schuler G. SULFATION PATHWAYS: Expression of SULT2A1, SULT2B1 and HSD3B1 in the porcine testis and epididymis. J Mol Endocrinol. 2018;61:M41-M55 pubmed publisher
    ..boars, the expression of sulfotransferases considered relevant for neutral hydroxysteroids (SULT2A1, SULT2B1) was investigated in the testis and defined segments of the epididymis applying real-time RT-qPCR, Western ..
  8. Zhang L, Chen Y, Yang X, Yang J, Cao X, Li X, et al. MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition. Biochim Biophys Acta. 2016;1861:1180-1191 pubmed publisher
    ..inhibitors was associated with activation of SIRT1, a positive regulator of LXR activity, and inactivation of SULT2B1 and RIP140, two negative regulators of LXR activity...
  9. Cornu J, Audet Walsh E, Drouin S, Bigot P, Valeri A, Fournier G, et al. Correlation between prostate volume and single nucleotide polymorphisms implicated in the steroid pathway. World J Urol. 2017;35:293-298 pubmed publisher
    ..hormone metabolism were significantly associated with prostate volume: HSD17B2 (rs1119933), ESR2 (rs8006145), SULT2B1 (rs279451), NQO1 (rs2917670), ESR1 (rs1569788), GSTP1 (rs1138272), and CYP19A1 (rs17523880)...
  10. Wang Z, Yang X, Chen L, Zhi X, Lu H, Ning Y, et al. Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury. Arch Toxicol. 2017;91:271-287 pubmed publisher
    ..Upon challenge with a hepatotoxic diet containing 0.1 % 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), SULT2B1-/- mice presented alleviated liver injury and less HOC proliferation compared with wild-type (WT) mice,..
  11. Visscher H, Rassekh S, Sandor G, Caron H, van Dalen E, Kremer L, et al. Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children. Pharmacogenomics. 2015;16:1065-76 pubmed publisher
    ..0071 and 0.047, respectively). Additional evidence was found for SULT2B1 and several genes related to oxidative stress...
  12. Fang J, Wu Y, Gamboa da Costa G, Chen S, Chitranshi P, Beland F. Human Sulfotransferases Enhance the Cytotoxicity of Tolvaptan. Toxicol Sci. 2016;150:27-39 pubmed publisher
    ..The affinity of individual SULT isozymes, as determined by Km analysis, was SULT1C3 >> SULT2A1 > SULT2B1 ∼ SULT1B1 > SULT1E1...
  13. Sumantran V, Mishra P, Bera R, Sudhakar N. Microarray Analysis of Differentially-Expressed Genes Encoding CYP450 and Phase II Drug Metabolizing Enzymes in Psoriasis and Melanoma. Pharmaceutics. 2016;8: pubmed publisher
    ..Genes controlling abnormal keratinocyte differentiation and epidermal barrier function (CYP4F22, SULT2B1) were up-regulated in psoriasis...
  14. Levesque E, Laverdière I, Audet Walsh E, Caron P, Rouleau M, Fradet Y, et al. Steroidogenic germline polymorphism predictors of prostate cancer progression in the estradiol pathway. Clin Cancer Res. 2014;20:2971-83 pubmed publisher
    ..4 years). Specifically, we examined 71 single-nucleotide polymorphisms (SNP) in SULT2A1, SULT2B1, CYP1B1, COMT, CYP3A4, CYP3A5, CYP3A43, NQO1, and NQO2 and assessed the impact of the SNPs alone and in ..
  15. Pai T, Sugahara T, Suiko M, Sakakibara Y, Xu F, Liu M. Differential xenoestrogen-sulfating activities of the human cytosolic sulfotransferases: molecular cloning, expression, and purification of human SULT2B1a and SULT2B1b sulfotransferases. Biochim Biophys Acta. 2002;1573:165-70 pubmed
    ..Kinetic studies on the sulfation of xenoestrogens by P-form (SULT1A1) PST were performed. The results are interpreted in the context of the endocrine-disrupting nature of these xenoestrogens. ..
  16. Hu L, Yang G, Zhang Y, Feng D, Zhai Y, Gong H, et al. Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma. Lab Invest. 2015;95:1005-18 pubmed publisher
    ..In conclusion, our findings suggest that SULT2B1b expression correlates with disease progression and metastasis and may serve as a novel prognostic biomarker and potential therapeutic target for patients with CRC. ..
  17. Hui Y, Luo L, Zhang L, Kurogi K, Zhou C, Sakakibara Y, et al. Sulfation of afimoxifene, endoxifen, raloxifene, and fulvestrant by the human cytosolic sulfotransferases (SULTs): A systematic analysis. J Pharmacol Sci. 2015;128:144-9 pubmed publisher
    ..Moreover, human intestine, kidney, liver, and lung cytosols were examined to verify the presence of afimoxifene/endoxifen/raloxifene/fulvestrant-sulfating activity. ..
  18. Heinz L, Kim G, Marrakchi S, Christiansen J, Turki H, Rauschendorf M, et al. Mutations in SULT2B1 Cause Autosomal-Recessive Congenital Ichthyosis in Humans. Am J Hum Genet. 2017;100:926-939 pubmed publisher
    ..6 ARCI-affected individuals from three unrelated families with mutations in Sulfotransferase family 2B member 1 (SULT2B1), showing their causative association with ARCI...
  19. Glatt H, Engelke C, Pabel U, Teubner W, Jones A, Coughtrie M, et al. Sulfotransferases: genetics and role in toxicology. Toxicol Lett. 2000;112-113:341-8 pubmed
    ..However, some promutagens were activated by only one or several of the human SULTs. Pronounced differences in promutagen activation were also detected between orthologous rat and human SULTs, and between allelic variants of human SULTs. ..
  20. Her C, Wood T, Eichler E, Mohrenweiser H, Ramagli L, Siciliano M, et al. Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene. Genomics. 1998;53:284-95 pubmed
    ..Northern blot analysis demonstrated the presence of SULT2B1 mRNA species approximately 1...
  21. Yang X, Xu Y, Guo F, Ning Y, Zhi X, Yin L, et al. Hydroxysteroid sulfotransferase SULT2B1b promotes hepatocellular carcinoma cells proliferation in vitro and in vivo. PLoS ONE. 2013;8:e60853 pubmed publisher
    ..In the present study, we found that SULT2B1 was comparatively higher in the human hepatocarcinoma tumorous tissues than their adjacent tissues...
  22. Weinshilboum R, Otterness D, Aksoy I, Wood T, Her C, Raftogianis R. Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. FASEB J. 1997;11:3-14 pubmed
  23. Fuda H, Lee Y, Shimizu C, Javitt N, Strott C. Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase. J Biol Chem. 2002;277:36161-6 pubmed
    ..The outstanding structural feature that distinguishes the SULT2B1 isoforms from the prototypical SULT2A1 isozyme is the presence of extended amino- and carboxyl-terminal ends in ..
  24. Chakraborti S, Bahnson B. Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions . Biochemistry. 2010;49:3436-44 pubmed publisher
    ..6 mum for Ca(2+), Mg(2+), Zn(2+), and Mn(2+), respectively), suggesting that the Ca(2+)-bound form may be physiologically relevant for stressed cells with an elevated free calcium level. ..
  25. Shi X, Cheng Q, Xu L, Yan J, Jiang M, He J, et al. Cholesterol sulfate and cholesterol sulfotransferase inhibit gluconeogenesis by targeting hepatocyte nuclear factor 4α. Mol Cell Biol. 2014;34:485-97 pubmed publisher
  26. Koizumi M, Momoeda M, Hiroi H, Hosokawa Y, Tsutsumi R, Osuga Y, et al. Expression and regulation of cholesterol sulfotransferase (SULT2B1b) in human endometrium. Fertil Steril. 2010;93:1538-44 pubmed publisher
    ..The expression of SULT2B1b mRNA in ESCs is induced by P and that in EECs is induced by relaxin via the cAMP pathway. ..
  27. Yanai H, Javitt N, Higashi Y, Fuda H, Strott C. Expression of cholesterol sulfotransferase (SULT2B1b) in human platelets. Circulation. 2004;109:92-6 pubmed
    ..Furthermore, the stability of SULT2B1b mRNA and protein in platelets maintained at 37 degrees C is subject to regulation by the apoA-I component of HDL. ..
  28. Lee Y, Higashi Y, Luu C, Shimizu C, Strott C. Sp1 elements in SULT2B1b promoter and 5'-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition. FEBS Lett. 2005;579:3639-45 pubmed
    The steroid/sterol sulfotransferase gene (SULT2B1) encodes for two isozymes of which one (SULT2B1b) sulfonates cholesterol and is selectively expressed in skin...
  29. Fuda H, Javitt N, Mitamura K, Ikegawa S, Strott C. Oxysterols are substrates for cholesterol sulfotransferase. J Lipid Res. 2007;48:1343-52 pubmed
    ..Thus, SULT2B1b, by acting on a variety of oxysterols, offers a potential pathway for modulating in vivo the injurious effects of these compounds. ..
  30. Allali Hassani A, Pan P, Dombrovski L, Najmanovich R, Tempel W, Dong A, et al. Structural and chemical profiling of the human cytosolic sulfotransferases. PLoS Biol. 2007;5:e97 pubmed
    ..The data help explain substrate promiscuity in this family and, at the same time, reveal new similarities between hSULT family members that were previously unrecognized by sequence or structure comparison alone. ..
  31. Ji Y, Moon I, Zlatkovic J, Salavaggione O, Thomae B, Eckloff B, et al. Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: gene sequence variation and functional genomics. J Pharmacol Exp Ther. 2007;322:529-40 pubmed
    ..The two SULT2B1 isoforms, SULT2B1a and SULT2B1b, are encoded by a single gene as a result of alternative transcription initiation ..
  32. Geese W, Raftogianis R. Biochemical characterization and tissue distribution of human SULT2B1. Biochem Biophys Res Commun. 2001;288:280-9 pubmed
    The human hydroxysteroid sulfotransferase (SULT) family is comprised of two subfamilies, SULT2A1 and SULT2B1. We characterized the substrate specificity, in vitro biochemical properties, and tissue distribution patterns of human SULT2B1a ..
  33. Glatt H, Boeing H, Engelke C, Ma L, Kuhlow A, Pabel U, et al. Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. Mutat Res. 2001;482:27-40 pubmed
    ..Only initial results are available from the analysis of SULT allele frequencies in different population groups, e.g. subjects suffering from specific diseases and corresponding controls. ..
  34. Stein K, Borowicki A, Scharlau D, Schettler A, Scheu K, Obst U, et al. Effects of synbiotic fermentation products on primary chemoprevention in human colon cells. J Nutr Biochem. 2012;23:777-84 pubmed publisher
    ..The cells were treated with the fs, and effects on gene expression of catalase, GSTP1 and SULT2B1, enzyme activity of catalase and glutathione S-transferase as well as H?O?-induced DNA damage were examined...
  35. Meloche C, Falany C. Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b). J Steroid Biochem Mol Biol. 2001;77:261-9 pubmed
    ..In contrast, characterization of the newly described human hydroxysteroid sulfotransferase SULT2B1 isoforms shows that these enzymes are selective for the sulfation of 3 beta-hydroxysteroids, such as pregnenolone,..
  36. Liang Y, Tang W, Huang T, Gao Y, Tan A, Yang X, et al. Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China. PLoS ONE. 2014;9:e97923 pubmed publisher
    ..023). We found candidate SNPs associated with elevated sCEA levels in both healthy males and CRC population. Rs1047781 (chr19- FUT2) may be the susceptible locus for recurrence of CRC in a population from Southern China. ..
  37. Probert P, Palmer J, Alhusainy W, Amer A, Rietjens I, White S, et al. Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1'-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism. Toxicol Lett. 2016;243:98-110 pubmed publisher
    ..B-13 and B-13/H cells expressed - relative to intact rat liver - high levels of SULT2B1 (primarily the b isoform) and SULT4A1 mRNAs and proteins...
  38. Javitt N, Lee Y, Shimizu C, Fuda H, Strott C. Cholesterol and hydroxycholesterol sulfotransferases: identification, distinction from dehydroepiandrosterone sulfotransferase, and differential tissue expression. Endocrinology. 2001;142:2978-84 pubmed
    ..Furthermore, this study represents the first example of the sulfonation of oxysterols by a specific human HST. ..
  39. Seo Y, Mirkheshti N, Song C, Kim S, Dodds S, Ahn S, et al. SULT2B1b sulfotransferase: induction by vitamin D receptor and reduced expression in prostate cancer. Mol Endocrinol. 2013;27:925-39 pubmed publisher
    ..Ligand-activated vitamin D receptor induced the SULT2B1 promoter in vivo in mouse prostate and increased SULT2B mRNA and protein levels in vitro in prostate cancer cells...
  40. He D, Frost A, Falany C. Identification and immunohistochemical localization of Sulfotransferase 2B1b (SULT2B1b) in human lung. Biochim Biophys Acta. 2005;1724:119-26 pubmed
    ..SULT2B1a and SULT2B1b are 350 and 365 AA in length, respectively. Northern blot analysis and SULT2B1 isoform specific RT-PCR detected only SULT2B1b message in human lung tissue...
  41. Higashi Y, Fuda H, Yanai H, Lee Y, Fukushige T, Kanzaki T, et al. Expression of cholesterol sulfotransferase (SULT2B1b) in human skin and primary cultures of human epidermal keratinocytes. J Invest Dermatol. 2004;122:1207-13 pubmed
    ..Additionally, 88% of cholesterol sulfate in NHEK was membrane-associated further suggesting a cellular location for cholesterol sulfate action. ..
  42. Falany C, Rohn Glowacki K. SULT2B1: unique properties and characteristics of a hydroxysteroid sulfotransferase family. Drug Metab Rev. 2013;45:388-400 pubmed publisher
    ..Although both SULT2B1 messages are present in human tissues, to date, only the SULT2B1b protein has been detected in the tissues ..