SULT1A1

Summary

Gene Symbol: SULT1A1
Description: sulfotransferase family 1A member 1
Alias: HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1, sulfotransferase 1A1, P-PST 1, aryl sulfotransferase 1, phenol-sulfating phenol sulfotransferase 1, sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1, thermostable phenol sulfotransferase1, ts-PST
Species: human
Products:     SULT1A1

Top Publications

  1. Wong C, Liyou N, Leggett B, Young J, Johnson A, McManus M. Association of the SULT1A1 R213H polymorphism with colorectal cancer. Clin Exp Pharmacol Physiol. 2002;29:754-8 pubmed
    ..The arylsulphotransferase SULT1A1 has been implicated in a decreased activity and thermostability when the wild-type arginine at position 213 of ..
  2. Zheng L, Wang Y, Schabath M, Grossman H, Wu X. Sulfotransferase 1A1 (SULT1A1) polymorphism and bladder cancer risk: a case-control study. Cancer Lett. 2003;202:61-9 pubmed
    ..b>SULT1A1 appears to be an important phenol SULT because of its abundance and distribution in many tissues and wide ..
  3. Kim K, Lee S, Park P, Ha J, Park J. Genetic polymorphisms and linkage disequilibrium of sulfotransferase SULT1A1 and SULT1A2 in a Korean population: comparison of other ethnic groups. Eur J Clin Pharmacol. 2005;61:743-7 pubmed
    ..Genotypes of the SULT1A1*1, *2, and *3 and SULT1A2*1, *2, and *3 allelic variants were determined in 234 Korean subjects using polymerase ..
  4. Gamage N, Tsvetanov S, Duggleby R, McManus M, Martin J. The structure of human SULT1A1 crystallized with estradiol. An insight into active site plasticity and substrate inhibition with multi-ring substrates. J Biol Chem. 2005;280:41482-6 pubmed
    Human SULT1A1 belongs to the supergene family of sulfotransferases (SULTs) involved in the sulfonation of xeno- and endobiotics...
  5. Shatalova E, Walther S, Favorova O, Rebbeck T, Blanchard R. Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study. Breast Cancer Res. 2005;7:R909-21 pubmed
    Estrogens are important in breast cancer development. SULT1A1 and UGT1A1 catalyze estrogen metabolism and are polymorphic...
  6. Cheng T, Chen S, Huang C, Fu Y, Yu J, Cheng C, et al. Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes: a multigenic study on cancer susceptibility. Int J Cancer. 2005;113:345-53 pubmed
    ..by conjugation reactions involving methylation (catechol-O-methyltransferase, COMT), sulfation (sulfotransferase 1A1, SULT1A1), or glucuronidation (UDP-glucuronosyltransferase 1A1, UGT1A1), one (manganese superoxide ..
  7. Williams J, Stone E, Fakis G, Johnson N, Cordell J, Meinl W, et al. N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast. Pharmacogenetics. 2001;11:373-88 pubmed
    ..Western blot analysis of mammary cytosolic protein showed detectable levels of SULT1A1 and SULT1A3.
  8. Fan C, Jin M, Chen K, Zhang Y, Zhang S, Liu B. Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer. BMC Cancer. 2007;7:115 pubmed
    ..was to measure the interactions between common polymorphisms of P450 (CYP1A2, CYP1B1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC)...
  9. Lilla C, Risch A, Kropp S, Chang Claude J. SULT1A1 genotype, active and passive smoking, and breast cancer risk by age 50 years in a German case-control study. Breast Cancer Res. 2005;7:R229-37 pubmed
    b>Sulfotransferase 1A1 (encoded by SULT1A1) is involved in the metabolism of procarcinogens such as heterocyclic amines and polycyclic aromatic hydrocarbons, both of which are present in tobacco smoke...
  10. Dooley T, Obermoeller R, Leiter E, Chapman H, Falany C, Deng Z, et al. Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7. Genomics. 1993;18:440-3 pubmed
    We have recently cloned a cDNA encoding the human phenol-preferring phenol sulfotransferase (P-PST) enzyme...

Detail Information

Publications82

  1. Wong C, Liyou N, Leggett B, Young J, Johnson A, McManus M. Association of the SULT1A1 R213H polymorphism with colorectal cancer. Clin Exp Pharmacol Physiol. 2002;29:754-8 pubmed
    ..The arylsulphotransferase SULT1A1 has been implicated in a decreased activity and thermostability when the wild-type arginine at position 213 of ..
  2. Zheng L, Wang Y, Schabath M, Grossman H, Wu X. Sulfotransferase 1A1 (SULT1A1) polymorphism and bladder cancer risk: a case-control study. Cancer Lett. 2003;202:61-9 pubmed
    ..b>SULT1A1 appears to be an important phenol SULT because of its abundance and distribution in many tissues and wide ..
  3. Kim K, Lee S, Park P, Ha J, Park J. Genetic polymorphisms and linkage disequilibrium of sulfotransferase SULT1A1 and SULT1A2 in a Korean population: comparison of other ethnic groups. Eur J Clin Pharmacol. 2005;61:743-7 pubmed
    ..Genotypes of the SULT1A1*1, *2, and *3 and SULT1A2*1, *2, and *3 allelic variants were determined in 234 Korean subjects using polymerase ..
  4. Gamage N, Tsvetanov S, Duggleby R, McManus M, Martin J. The structure of human SULT1A1 crystallized with estradiol. An insight into active site plasticity and substrate inhibition with multi-ring substrates. J Biol Chem. 2005;280:41482-6 pubmed
    Human SULT1A1 belongs to the supergene family of sulfotransferases (SULTs) involved in the sulfonation of xeno- and endobiotics...
  5. Shatalova E, Walther S, Favorova O, Rebbeck T, Blanchard R. Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study. Breast Cancer Res. 2005;7:R909-21 pubmed
    Estrogens are important in breast cancer development. SULT1A1 and UGT1A1 catalyze estrogen metabolism and are polymorphic...
  6. Cheng T, Chen S, Huang C, Fu Y, Yu J, Cheng C, et al. Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes: a multigenic study on cancer susceptibility. Int J Cancer. 2005;113:345-53 pubmed
    ..by conjugation reactions involving methylation (catechol-O-methyltransferase, COMT), sulfation (sulfotransferase 1A1, SULT1A1), or glucuronidation (UDP-glucuronosyltransferase 1A1, UGT1A1), one (manganese superoxide ..
  7. Williams J, Stone E, Fakis G, Johnson N, Cordell J, Meinl W, et al. N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast. Pharmacogenetics. 2001;11:373-88 pubmed
    ..Western blot analysis of mammary cytosolic protein showed detectable levels of SULT1A1 and SULT1A3.
  8. Fan C, Jin M, Chen K, Zhang Y, Zhang S, Liu B. Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer. BMC Cancer. 2007;7:115 pubmed
    ..was to measure the interactions between common polymorphisms of P450 (CYP1A2, CYP1B1, CYP2E1), GSTM1 and T1, SULT1A1 and cigarette smoking in colorectal cancer (CRC)...
  9. Lilla C, Risch A, Kropp S, Chang Claude J. SULT1A1 genotype, active and passive smoking, and breast cancer risk by age 50 years in a German case-control study. Breast Cancer Res. 2005;7:R229-37 pubmed
    b>Sulfotransferase 1A1 (encoded by SULT1A1) is involved in the metabolism of procarcinogens such as heterocyclic amines and polycyclic aromatic hydrocarbons, both of which are present in tobacco smoke...
  10. Dooley T, Obermoeller R, Leiter E, Chapman H, Falany C, Deng Z, et al. Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7. Genomics. 1993;18:440-3 pubmed
    We have recently cloned a cDNA encoding the human phenol-preferring phenol sulfotransferase (P-PST) enzyme...
  11. Koike H, Nakazato H, Ohtake N, Matsui H, Okugi H, Shibata Y, et al. Further evidence for null association of phenol sulfotransferase SULT1A1 polymorphism with prostate cancer risk: a case-control study of familial prostate cancer in a Japanese population. Int Urol Nephrol. 2008;40:947-51 pubmed publisher
    Sulfation is a key pathway in xenobiotic metabolism and chemical defense, and phenol sulfotransferase SULT1A1 plays a central role in this reaction...
  12. Saintot M, Malaveille C, Hautefeuille A, Gerber M. Interactions between genetic polymorphism of cytochrome P450-1B1, sulfotransferase 1A1, catechol-o-methyltransferase and tobacco exposure in breast cancer risk. Int J Cancer. 2003;107:652-7 pubmed
    ..ORi) between smoking habits and the gene polymorphisms of Cytochrome P450 1B1 (Val432Leu CYP1B1), Phenol-sulfotransferase 1A1 (Arg213His SULT1A1) and Catechol-O-methyltransferase (Val158Met COMT)...
  13. Allali Hassani A, Pan P, Dombrovski L, Najmanovich R, Tempel W, Dong A, et al. Structural and chemical profiling of the human cytosolic sulfotransferases. PLoS Biol. 2007;5:e97 pubmed
    ..The data help explain substrate promiscuity in this family and, at the same time, reveal new similarities between hSULT family members that were previously unrecognized by sequence or structure comparison alone. ..
  14. Nowell S, Ahn J, Rae J, Scheys J, Trovato A, Sweeney C, et al. Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients. Breast Cancer Res Treat. 2005;91:249-58 pubmed
    ..We also examined whether the combination of variant alleles in SULT1A1 and UGT2B15 had more of an impact on overall survival in tamoxifen-treated patients than when the genes were ..
  15. Glatt H, Boeing H, Engelke C, Ma L, Kuhlow A, Pabel U, et al. Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. Mutat Res. 2001;482:27-40 pubmed
    ..Only initial results are available from the analysis of SULT allele frequencies in different population groups, e.g. subjects suffering from specific diseases and corresponding controls. ..
  16. Han D, Zhou X, Hu M, Xie W, Mao Z, Chen D, et al. Polymorphisms of estrogen-metabolizing genes and breast cancer risk: a multigenic study. Chin Med J (Engl). 2005;118:1507-16 pubmed
    ..CYP17, cytochrome P450c17a and CYP19, aromatase cytochrome P450) and estrogen sulfation of inactivation (SULT1A1, sulfotransferase1A1) and the risk of breast cancer in Chinese women...
  17. Wegman P, Elingarami S, Carstensen J, Stal O, Nordenskjold B, Wingren S. Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. Breast Cancer Res. 2007;9:R7 pubmed
    ..value of functional polymorphisms in cytochrome P450 3A5 CYP3A5 (*3), CYP2D6 (*4), sulphotransferase 1A1 (SULT1A1; *2) and UDP-glucuronosyltransferase 2B15 (UGT2B15; *2) in tamoxifen-treated patients with breast cancer...
  18. Kotnis A, Kannan S, Sarin R, Mulherkar R. Case-control study and meta-analysis of SULT1A1 Arg213His polymorphism for gene, ethnicity and environment interaction for cancer risk. Br J Cancer. 2008;99:1340-7 pubmed publisher
    Cytosolic sulphotransferase SULT1A1 plays a dual role in the activation of some carcinogens and inactivation of others...
  19. Bamber D, Fryer A, Strange R, Elder J, Deakin M, Rajagopal R, et al. Phenol sulphotransferase SULT1A1*1 genotype is associated with reduced risk of colorectal cancer. Pharmacogenetics. 2001;11:679-85 pubmed
    ..A major sulphotransferase (SULT) enzyme in humans, SULT1A1, is polymorphic with the most common variant allele, SULT1A1*2, occurring at a frequency of about 32% in the ..
  20. Wu M, Wang Y, Ho C, Wu D, Lee Y, Hsu H, et al. SULT1A1 polymorphism and esophageal cancer in males. Int J Cancer. 2003;103:101-4 pubmed
    ..It has been suggested that the SULT1A1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G-->A transition at ..
  21. Khvostova E, Pustylnyak V, Gulyaeva L. Genetic polymorphism of estrogen metabolizing enzymes in Siberian women with breast cancer. Genet Test Mol Biomarkers. 2012;16:167-73 pubmed publisher
    Allelic variants of cytochrome P450: CYP1A1, CYP1A2, CYP19 (aromatase), and the II-phase enzyme sulfotransferase 1A1 (SULT1A1) genes are associated with a high risk of hormone-dependent cancers...
  22. Wang Y, Juang G, Hwang T, Shen C, Shao K, Chiou H. Genetic polymorphism of sulfotransferase 1A1, cigarette smoking, hazardous chemical exposure and urothelial cancer risk in a Taiwanese population. Int J Urol. 2008;15:1029-34 pubmed publisher
    To investigate the association between genetic polymorphism of sulfotransferase1A1 (SULT1A1), cigarette smoking, hazardous chemical exposure and urothelial cancer risk in a Taiwanese population...
  23. Eagle K. Hypothesis: holiday sudden cardiac death: food and alcohol inhibition of SULT1A enzymes as a precipitant. J Appl Toxicol. 2012;32:751-5 pubmed publisher
    ..This hypothesis also raises parallels between sudden cardiac death in adults and Sudden Infant Death Syndrome (SIDS). The possible involvement of SULT1A inhibition in SIDS is discussed. ..
  24. Mikhailova O, Gulyaeva L, Prudnikov A, Gerasimov A, Krasilnikov S. Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk. Pharmacogenomics J. 2006;6:189-93 pubmed
    Allelic variants of cytochrome P450: CYP1A1, CYP1A2, CYP19 (Aromatase) and II-phase enzyme Sulfotransferase (SULT1A1) genes are associated with a high risk of hormone-dependent cancers...
  25. Gjerde J, Hauglid M, Breilid H, Lundgren S, Varhaug J, Kisanga E, et al. Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Ann Oncol. 2008;19:56-61 pubmed
    ..Clinical studies indicate that CYP2D6 and SULT1A1 genotypes are predictors for treatment response to tamoxifen...
  26. Sun Y, Zang Z, Xu X, Zhang Z, Zhong L, Zan W, et al. The association of SULT1A1 codon 213 polymorphism and breast cancer susceptibility: meta-analysis from 16 studies involving 23,445 subjects. Breast Cancer Res Treat. 2011;125:215-9 pubmed publisher
    Epidemiological studies on the association between SULT1A1 codon 213 polymorphism and breast cancer risk are inconclusive. In order to derive a more precise estimation of the association, a meta-analysis was conducted in this article...
  27. Lumbreras B, Garte S, Overvad K, Tjonneland A, Clavel Chapelon F, Linseisen J, et al. Meat intake and bladder cancer in a prospective study: a role for heterocyclic aromatic amines?. Cancer Causes Control. 2008;19:649-56 pubmed publisher
    ..The role of SULT1A1 and of NAT2 on the activation of HAAs suggests that NAT2 rapid acetylator genotype and SULT1A1 allele variants ..
  28. Hung R, Boffetta P, Brennan P, Malaveille C, Hautefeuille A, Donato F, et al. GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population. Int J Cancer. 2004;110:598-604 pubmed
    ..Cytochrome p450 1B1 (CYP1B1) and sulfotransferase 1A1 (SULT1A1) are also involved in the metabolism of PAHs and aromatic amines...
  29. Zheng W, Xie D, Cerhan J, Sellers T, Wen W, Folsom A. Sulfotransferase 1A1 polymorphism, endogenous estrogen exposure, well-done meat intake, and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2001;10:89-94 pubmed
    ..A G--->A transition at codon 213 (CGC/Arg to CAC/His) of the SULT1A1 gene was reported recently, and individuals homozygous for the His allele have a substantially lower activity of ..
  30. Peng C, Chen J, Yeh K, Wang Y, Hou M, Lee T, et al. The relationship among the polymorphisms of SULT1A1, 1A2 and different types of cancers in Taiwanese. Int J Mol Med. 2003;11:85-9 pubmed
    ..The genes for SULT1A1 and SULT1A2 contain common genetic polymorphisms that are associated with individual variations in the level of ..
  31. Grabinski J, Smith L, Chisholm G, Drengler R, Rodriguez G, Lang A, et al. Genotypic and allelic frequencies of SULT1A1 polymorphisms in women receiving adjuvant tamoxifen therapy. Breast Cancer Res Treat. 2006;95:13-6 pubmed
    Human sulfotransferase 1A1 (SULT1A1) is involved in the metabolism of a number of substances including 4-hydroxytamoxifen. It has been shown that patients who are homozygous for the variant SULT1A1 *2/*2 have lower catalytic activity...
  32. Seth P, Lunetta K, Bell D, Gray H, Nasser S, Rhei E, et al. Phenol sulfotransferases: hormonal regulation, polymorphism, and age of onset of breast cancer. Cancer Res. 2000;60:6859-63 pubmed
    ..Using an RFLP that distinguishes an arginine to histidine change in exon 7 of the SULT1A1 gene, we characterized SULT1A1 genotypes in relation to breast cancer risk...
  33. Cotterchio M, Boucher B, Manno M, Gallinger S, Okey A, Harper P. Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2008;17:3098-107 pubmed publisher
    ..associated with increased colorectal cancer risk regardless of genotypes; however, CYP1B1 combined variant and SULT1A1-638G>A variant significantly modified the association between red meat doneness intake and colorectal cancer ..
  34. Kellen E, Zeegers M, Paulussen A, van Dongen M, Buntinx F. Fruit consumption reduces the effect of smoking on bladder cancer risk. The Belgian case control study on bladder cancer. Int J Cancer. 2006;118:2572-8 pubmed
    ..We also evaluated interaction between fruit intake and GSTM1, GSTT1, NAT2 and SULT1A1 amongst "ever-smokers...
  35. Gulyaeva L, Mikhailova O, PustyInyak V, Kim I, Gerasimov A, Krasilnikov S, et al. Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia. Adv Exp Med Biol. 2008;617:359-66 pubmed publisher
    We estimated the frequency of CYP1A1, CYP1A2, CYP1B1, CYP19, and SULT1A1 allelic variants in a female population of the Novosibirsk district and their association with the elevated risk of breast (BC), ovarian (OC), and endometrial (EC) ..
  36. Wang Z, Fu Y, Tang C, Lu S, Chu W. SULT1A1 R213H polymorphism and breast cancer risk: a meta-analysis based on 8,454 cases and 11,800 controls. Breast Cancer Res Treat. 2010;122:193-8 pubmed publisher
    The SULT1A1 R213H polymorphism is suggested to be implicated in the development and progression of breast cancer. However, the published findings are inconsistent...
  37. Weinshilboum R, Otterness D, Aksoy I, Wood T, Her C, Raftogianis R. Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. FASEB J. 1997;11:3-14 pubmed
    ..ST enzymes are members of an emerging gene superfamily that presently includes phenol ST (PST), hydroxysteroid ST (HSST), and, in plants, flavonol ST (FST) "families," members of which share at least ..
  38. Wang Y, Spitz M, Tsou A, Zhang K, Makan N, Wu X. Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis. Lung Cancer. 2002;35:137-42 pubmed
    b>SULT1A1 enzyme is a member of the sulfotransferase family that alters biological activities of numerous carcinogenic and mutagenic compounds through sulfation...
  39. Langsenlehner U, Krippl P, Renner W, Yazdani Biuki B, Eder T, Wolf G, et al. Genetic variants of the sulfotransferase 1A1 and breast cancer risk. Breast Cancer Res Treat. 2004;87:19-22 pubmed
    b>Sulfotransferase 1A1 (SULT1A1), also designated as phenol-preferring sulfotransferase, is involved in the bioactivation and detoxification of a variety of potential carcinogens, including iodothyronines, hydroxylated aromatic amines, and ..
  40. Ozawa S, Katoh T, Inatomi H, Imai H, Kuroda Y, Ichiba M, et al. Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population. Int J Cancer. 2002;102:418-21 pubmed
    ..CYP) 1A2 and subsequently through O-sulfation and O-acetylation by phenol sulfating sulfotransferase, ST1A3 (SULT1A1), and arylamine N-acetyltransferase, NAT2, respectively...
  41. Carlini E, Raftogianis R, Wood T, Jin F, Zheng W, Rebbeck T, et al. Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects. Pharmacogenetics. 2001;11:57-68 pubmed
    ..The genes for SULT1A1 and SULT1A2 contain common genetic polymorphisms that are associated with individual variations in levels of ..
  42. Hebbring S, Adjei A, Baer J, Jenkins G, Zhang J, Cunningham J, et al. Human SULT1A1 gene: copy number differences and functional implications. Hum Mol Genet. 2007;16:463-70 pubmed
    b>SULT1A1, which catalyzes the sulfate conjugation of a wide variety of natural and synthetic compounds, is genetically polymorphic...
  43. Gamage N, Duggleby R, Barnett A, Tresillian M, Latham C, Liyou N, et al. Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition. J Biol Chem. 2003;278:7655-62 pubmed
    ..A major human sulfotransferase, SULT1A1, metabolizes and/or bioactivates many endogenous compounds and is implicated in a range of cancers because of its ..
  44. Gaustadnes M, ├śrntoft T, Jensen J, Torring N. Validation of the use of DNA pools and primer extension in association studies of sporadic colorectal cancer for selection of candidate SNPs. Hum Mutat. 2006;27:187-94 pubmed
    ..92945042C>T (3'UTR 96516), GSTP1 c.342A>C (p.Ile105Val), GSTM1 c.573C>G (p.Lys173Asn), and SULT1A1 g.19934792G>A (p.Arg213His). All were borderline significant, and none were significant at the 5% level...
  45. Glatt H. Sulfotransferases in the bioactivation of xenobiotics. Chem Biol Interact. 2000;129:141-70 pubmed
    ..Common functionally relevant genetic polymorphisms of the transcribed region are known for two of the forms, SULT1A1 and 1A2...
  46. Tsukino H, Kuroda Y, Nakao H, Imai H, Inatomi H, Osada Y, et al. Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer. J Cancer Res Clin Oncol. 2004;130:99-106 pubmed
    ..Recently, several polymorphisms of CYP1A2, SULT1A1, and NAT2 that affect their activities have been reported...
  47. Arslan S, Silig Y, Pinarbasi H. An investigation of the relationship between SULT1A1 Arg(213)His polymorphism and lung cancer susceptibility in a Turkish population. Cell Biochem Funct. 2009;27:211-5 pubmed publisher
    Human sulfotransferase 1A1 (SULT1A1), the most expressed isoform of the phenol SULT1 subfamily, is an important member of sulfotransferase superfamily. A transition, G to A at position 638, in SULT1A1 gene, results in Arg(213)His change...
  48. . Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. Breast Cancer Res Treat. 2010;119:463-74 pubmed publisher
    ..CYP2C9, CYP2C19, CYP3A4, CYP3A5, CYP3A7) and nine genes of phase II enzymes (COMT, GSTM1, GSTM3, GSTP1, GSTT1, SULT1A1, UGT1A1, UGT1A6, UGT2B7) were genotyped...
  49. Le Marchand L, Donlon T, Kolonel L, Henderson B, Wilkens L. Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 2005;14:1998-2003 pubmed
    ..The findings provide no evidence for a role of COMT Val58Met, CYP1A1*2A, CYP3A4*1B, CYP1B1 Leu432Val, SULT1A1 Arg213His, and AHR Arg554Lys in breast cancer etiology...
  50. Wegman P, Vainikka L, Stal O, Nordenskjold B, Skoog L, Rutqvist L, et al. Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients. Breast Cancer Res. 2005;7:R284-90 pubmed
    ..Cytochrome P450 2D6 (CYP2D6) and sulfotransferase 1A1 (SULT1A1) are polymorphic and are involved in the metabolism of tamoxifen...
  51. Knechtel G, HOFMANN G, Gerger A, Renner W, Langsenlehner T, Szkandera J, et al. Analysis of common germline polymorphisms as prognostic factors in patients with lymph node-positive breast cancer. J Cancer Res Clin Oncol. 2010;136:1813-9 pubmed publisher
    ..807C>T, ITGA2 1648G>A, ITGB3 176T>C, MMP1 -1607 1G/2G, MMP3 5A/6A, PTGS2 8473T>C, IL10 592C>A and SULT1A1 638G>A polymorphisms and disease-free survival or overall survival...
  52. Syamala V, Syamala V, Sheeja V, Kuttan R, Balakrishnan R, Ankathil R. Possible risk modification by polymorphisms of estrogen metabolizing genes in familial breast cancer susceptibility in an Indian population. Cancer Invest. 2010;28:304-11 pubmed publisher
    ..whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk...
  53. Lee H, Wang Q, Yang F, Tao P, Li H, Huang Y, et al. SULT1A1 Arg213His polymorphism, smoked meat, and breast cancer risk: a case-control study and meta-analysis. DNA Cell Biol. 2012;31:688-99 pubmed publisher
    b>SULT1A1 is involved in both detoxification of estrogens and bioactivation of carcinogens in smoked meat. SULT1A1 Arg213His polymorphism's effect on breast cancer risk is still unclear...
  54. Veronese M, Burgess W, Zhu X, McManus M. Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies. Biochem J. 1994;302 ( Pt 2):497-502 pubmed
    ..that HAST1 was considerably more thermostable (TS) than HAST3, which is consistent with P-PST being termed the TS PST and M-PST being termed the thermolabile (TL) PST...
  55. Wang Y, Lee Y, Tseng P, Shen C, Chiou H. Human NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan. J Cancer Res Clin Oncol. 2008;134:203-9 pubmed
    To investigate whether the NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms are associated with urothelial cancer (UC) risk in Taiwan...
  56. Rebbeck T, Troxel A, Walker A, Panossian S, Gallagher S, Shatalova E, et al. Pairwise combinations of estrogen metabolism genotypes in postmenopausal breast cancer etiology. Cancer Epidemiol Biomarkers Prev. 2007;16:444-50 pubmed
    ..interactions in African Americans and European Americans for genotypes at COMT, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SULT1A1, and SULT1E1 in 878 breast cancer cases and 1,409 matched random digit-dialed controls...
  57. Bardakci F, Arslan S, Bardakci S, Binatli A, Budak M. Sulfotransferase 1A1 (SULT1A1) polymorphism and susceptibility to primary brain tumors. J Cancer Res Clin Oncol. 2008;134:109-14 pubmed
    b>Sulfotransferase 1A1 is a member of sulfotransferase family that plays an important role in the biotransformation of numerous carcinogenic and mutagenic compounds through sulfation...
  58. Jin Y, Desta Z, Stearns V, Ward B, Ho H, Lee K, et al. CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst. 2005;97:30-9 pubmed
    ..Genetic variations of CYP2C9, CYP3A5, or SULT1A1 had no statistically significant associations with plasma concentrations of tamoxifen or its metabolites...
  59. Boccia S, Cadoni G, La Torre G, Arzani D, Volante M, Cattel C, et al. A case-control study investigating the role of sulfotransferase 1A1 polymorphism in head and neck cancer. J Cancer Res Clin Oncol. 2006;132:466-72 pubmed
    Sulfotransferases (SULT) 1A1 detoxify and bio-activate a broad spectrum of substrates including xenobiotics. The SULT1A1 gene possesses a G-->A polymorphism that results in an Arg to His substitution at codon 213, with the His allele ..
  60. Sun X, Ahmadi A, Arbman G, Wallin A, Asklid D, Zhang H. Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients' survival. World J Gastroenterol. 2005;11:6875-9 pubmed
    To examine whether polymorphisms in SULT1A1 and GSTP1 genes contribute to colorectal cancer development and whether they are associated with clinicopathological variables are not well identified...
  61. Liang G, Miao X, Zhou Y, Tan W, Lin D. A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking. Carcinogenesis. 2004;25:773-8 pubmed
    b>Sulfotransferase 1A1, an important member of sulfotransferase superfamily, is involved in the biotransformation of many compounds including tobacco carcinogens...
  62. Boccia S, Persiani R, La Torre G, Rausei S, Arzani D, Gianfagna F, et al. Sulfotransferase 1A1 polymorphism and gastric cancer risk: a pilot case-control study. Cancer Lett. 2005;229:235-43 pubmed
    ..The SULT1A1 gene possesses a G-->A polymorphism that results in a Arg to His substitution at codon 213, and the His allele ..
  63. Nowell S, Sweeney C, Winters M, Stone A, Lang N, Hutchins L, et al. Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy. J Natl Cancer Inst. 2002;94:1635-40 pubmed
    Human sulfotransferase 1A1 (SULT1A1) catalyzes the sulfation of a variety of phenolic and estrogenic compounds, including 4-hydroxytamoxifen (4-OH TAM), the active metabolite of tamoxifen...
  64. Chacko P, Rajan B, Mathew B, Joseph T, Pillai M. CYP17 and SULT1A1 gene polymorphisms in Indian breast cancer. Breast Cancer. 2004;11:380-8 pubmed
    ..The CYP17 and SULT1A1 genes encode for two enzymes involved in hormone biosynthesis and metabolism...
  65. Li K, Ren Y, Wan Y, Yin Z, Wu W, Zhou B. SULT1A1 Arg213His polymorphism and susceptibility of environment-related cancers: a meta analysis of 5,915 cases and 7,900 controls. Mol Biol Rep. 2012;39:2597-605 pubmed publisher
    The common genetic polymorphism for SULT1A1 is Arg213His polymorphism, which may affect the sulfation process of various environmental carcinogens and thus is suggested to be related to susceptibility of several cancers...
  66. Raftogianis R, Wood T, Otterness D, Van Loon J, Weinshilboum R. Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype. Biochem Biophys Res Commun. 1997;239:298-304 pubmed
    ..Three highly homologous PST genes, SULT1A1, SULT1A2, and SULT1A3, are known to exist in humans...
  67. Engelke C, Meinl W, Boeing H, Glatt H. Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2. Pharmacogenetics. 2000;10:163-9 pubmed
    Three human phenol sulfotransferases, provisionally named SULT1A1, 1A2 and 1A3, show 91-96% homology of their amino acid sequences and are encoded by neighbouring gene loci...
  68. Serrano D, Lazzeroni M, Zambon C, Macis D, Maisonneuve P, Johansson H, et al. Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial. Pharmacogenomics J. 2011;11:100-7 pubmed publisher
    ..role of pharmacogenomics and tamoxifen was investigated by analyzing several polymorphisms of cytochrome P450 and SULT1A1 gene in a nested case control study from the Italian Tamoxifen Prevention Trial...
  69. Han D, Zhou X, Hu M, Wang C, Xie W, Tan X, et al. Sulfotransferase 1A1 (SULT1A1) polymorphism and breast cancer risk in Chinese women. Toxicol Lett. 2004;150:167-77 pubmed
    ..A major human sulfotransferase, SULT1A1, catalyzes the sulfation of a variety of phenolic and estrogenic compounds...
  70. Barnett A, Tsvetanov S, Gamage N, Martin J, Duggleby R, McManus M. Active site mutations and substrate inhibition in human sulfotransferase 1A1 and 1A3. J Biol Chem. 2004;279:18799-805 pubmed
    Human SULT1A1 is primarily responsible for sulfonation of xenobiotics, including the activation of promutagens, and it has been implicated in several forms of cancer...
  71. Tang D, Rundle A, Mooney L, Cho S, Schnabel F, Estabrook A, et al. Sulfotransferase 1A1 (SULT1A1) polymorphism, PAH-DNA adduct levels in breast tissue and breast cancer risk in a case-control study. Breast Cancer Res Treat. 2003;78:217-22 pubmed
    ..between genetic susceptibility due to inherited polymorphisms of the Phase II detoxification enzyme sulfotransferase 1A1 (SULT1A1), breast cancer risk, and polycyclic aromatic hydrocarbon (PAH)-DNA adducts...
  72. Sellers T, Schildkraut J, Pankratz V, Vierkant R, Fredericksen Z, Olson J, et al. Estrogen bioactivation, genetic polymorphisms, and ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2005;14:2536-43 pubmed
    ..polymorphisms in four genes involved in catechol estrogen formation (CYP1A1 and CYP1B1) or conjugation (COMT and SULT1A1)...
  73. Sachse C, Smith G, Wilkie M, Barrett J, Waxman R, Sullivan F, et al. A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. Carcinogenesis. 2002;23:1839-49 pubmed
    ..CYP2A6, CYP2C9, CYP2C19 and CYP2D6), glutathione S-transferase (GSTM1, GSTP1 and GSTT1), sulfotransferase (SULT1A1 and SULT1A2), N-acetyl transferase 2 (NAT2), NAD(P)H:quinone oxidoreductase (NQO1), methylenetetrahydrofolate ..
  74. Roupret M, Cancel Tassin G, Comperat E, Fromont G, Sibony M, Molinie V, et al. Phenol sulfotransferase SULT1A1*2 allele and enhanced risk of upper urinary tract urothelial cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2007;16:2500-3 pubmed
    Cytosolic sulfotransferases (SULT) are involved in detoxification pathways. A functional polymorphism in the SULT1A1 gene, leading to an Arg213His substitution (SULT1A1*2), is thought to confer susceptibility to various types of cancer...
  75. Boccia S, Sayed Tabatabaei F, Persiani R, Gianfagna F, Rausei S, Arzani D, et al. Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population. BMC Cancer. 2007;7:206 pubmed
    ..254 hospital controls, matched by age and gender, were genotyped for CYP1A1, CYP2E1, mEH, GSTM1, GSTT1, NAT2 and SULT1A1 polymorphisms...
  76. Chen K, Fan C, Jin M, Song L, Xu H, He H, et al. [A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer]. Zhonghua Zhong Liu Za Zhi. 2006;28:670-3 pubmed
    ..A case-control study of 140 cancers and 343 health controls was conducted to investigate the role of sulfotransferase 1A1 polymorphism and meat consumption in colorectal carcinogenesis...
  77. Choi J, Lee K, Park S, Noh D, Ahn S, Chung H, et al. Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer. Cancer Epidemiol Biomarkers Prev. 2005;14:1090-5 pubmed
    We examined whether common single nucleotide polymorphisms (SNP) in SULT1A1 (c.779G>A, *14A>G, and *85C>T) and SULT1E1 (IVS1-447C>A, IVS4-1653T>C, and *959G>A) genes influenced the risk and survival of breast cancer...
  78. Hirata H, Hinoda Y, Okayama N, Suehiro Y, Kawamoto K, Kikuno N, et al. CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility. Cancer. 2008;112:1964-73 pubmed publisher
    ..that single nucleotide polymorphisms (single nucleotide polymorphisms) of CYP1A1, CYP1A2, CYP1B1, CYP17, SULT1A1, SULT1E1, and SHBG genes may be risk factors for endometrial cancer...
  79. Sparks R, Ulrich C, Bigler J, Tworoger S, Yasui Y, Rajan K, et al. UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. Breast Cancer Res. 2004;6:R488-98 pubmed
    ..five UGT and SULT genes - UGT1A1 ((TA)6/(TA)7), UGT2B4 (Asp458Glu), UGT2B7 (His268Tyr), UGT2B15 (Asp85Tyr), and SULT1A1 (Arg213His)--may be associated with circulating sex hormone concentrations, or the risk of an estrogen receptor-..