SUCLA2

Summary

Gene Symbol: SUCLA2
Description: succinate-CoA ligase ADP-forming beta subunit
Alias: A-BETA, A-SCS, MTDPS5, SCS-betaA, succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial, ATP-specific succinyl-CoA synthetase subunit beta, ATP-specific succinyl-CoA synthetase, beta subunit, mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta, renal carcinoma antigen NY-REN-39, succinate-CoA ligase beta subunit, succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial, succinyl-CoA synthetase beta-A chain
Species: human
Products:     SUCLA2

Top Publications

  1. Johnson J, Mehus J, Tews K, Milavetz B, Lambeth D. Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. J Biol Chem. 1998;273:27580-6 pubmed
    ..The expression of A-beta is strong in numerous mouse and human tissues, which suggests that ATP-specific succinyl-CoA synthetase also plays an important role in species throughout the animal kingdom...
  2. Elpeleg O, Miller C, Hershkovitz E, Bitner Glindzicz M, Bondi Rubinstein G, Rahman S, et al. Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion. Am J Hum Genet. 2005;76:1081-6 pubmed
    ..Markedly decreased succinyl-CoA synthetase activity due to a deleterious mutation in SUCLA2, the gene encoding the beta subunit of the ADP-forming succinyl-CoA synthetase ligase, was found in muscle ..
  3. Schmitz T, Sentilhes L, Lorthe E, Gallot D, Madar H, Doret Dion M, et al. Preterm premature rupture of the membranes: Guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF). Eur J Obstet Gynecol Reprod Biol. 2019;236:1-6 pubmed publisher
    ..of intrauterine infection, the immediate intravenous administration (Grade B) of antibiotic therapy combining a beta-lactam with an aminoglycoside (Grade B) and early delivery of the child are both recommended (Grade A)...
  4. Ng C, Tay M, Tan B, Le T, Haller L, Chen H, et al. Characterization of Metagenomes in Urban Aquatic Compartments Reveals High Prevalence of Clinically Relevant Antibiotic Resistance Genes in Wastewaters. Front Microbiol. 2017;8:2200 pubmed publisher
    ..Wastewater had a distinctively higher average abundance of clinically relevant, class A beta-lactamase resistant genes (i.e...
  5. Köse S, Nazıroğlu M. N-acetyl cysteine reduces oxidative toxicity, apoptosis, and calcium entry through TRPV1 channels in the neutrophils of patients with polycystic ovary syndrome. Free Radic Res. 2015;49:338-46 pubmed publisher
    ..In conclusion, NAC reduced oxidative stress, apoptosis, cytokine levels, and Ca(2+) entry through TRPV1 channel, which provide supportive evidence that oxidative stress and TRPV1 channel plays a key role in etiology of PCOS. ..
  6. Cherif B, Triki H, Sahnoun S, Hamden K, Sallemi A, Charfi S, et al. Imipenem toxicity in male reproductive organs as a result of inflammatory microenvironment and oxidative stress in germinal cells. Toxicology. 2019;416:44-53 pubmed publisher
    Imipenem is a beta-Lactam antibiotic characterized by a broad spectrum of activity. It is prescribed to treat severe infections...
  7. Wu H, Perrard X, Wang Q, Perrard J, Polsani V, Jones P, et al. CD11c expression in adipose tissue and blood and its role in diet-induced obesity. Arterioscler Thromb Vasc Biol. 2010;30:186-92 pubmed publisher
    To examine CD11c, a beta(2)-integrin, on adipose tissue (AT) leukocytes and blood monocytes and its role in diet-induced obesity. High-fat diet-induced obese C57BL/6 mice, CD11c-deficient mice, and obese humans were studied...
  8. Conde Díaz C, Llenas García J, Parra Grande M, Terol Esclapez G, Masia M, Gutierrez F. Severe skull base osteomyelitis caused by Pseudomonas aeruginosa with successful outcome after prolonged outpatient therapy with continuous infusion of ceftazidime and oral ciprofloxacin: a case report. J Med Case Rep. 2017;11:48 pubmed publisher
    ..treatment, our patient was discharged and treatment was continued with a domiciliary continuous infusion of a beta-lactam through a peripherally inserted central catheter, along with an oral fluoroquinolone for 10 months...
  9. Sanchez Ramos J, Song S, Sava V, Catlow B, Lin X, Mori T, et al. Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice. Neuroscience. 2009;163:55-72 pubmed publisher
    ..of G-CSF administration would have an impact on the pathological hallmark of AD, the age-dependent accumulation of A beta deposits, in a transgenic mouse model of AD (APP+ PS1; Tg)...

More Information

Publications152 found, 100 shown here

  1. Chen D, Su A, Fu Y, Wang X, Lv X, Xu W, et al. Harmine blocks herpes simplex virus infection through downregulating cellular NF-κB and MAPK pathways induced by oxidative stress. Antiviral Res. 2015;123:27-38 pubmed publisher
    ..Harmine, a beta-carbon alkaloid with an indole core structure and a pyridine ring, is widely distributed in plants...
  2. Pospisilik J, Martin J, Doty T, Ehses J, Pamir N, Lynn F, et al. Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats. Diabetes. 2003;52:741-50 pubmed
    ..In vitro studies using a beta-(INS-1) cell line showed a dose-dependent prevention of STZ-induced apoptotic cell-death by both GIP and GLP-1, ..
  3. Bassi G, do C Malvar D, Cunha T, Cunha F, Kanashiro A. Spinal GABA-B receptor modulates neutrophil recruitment to the knee joint in zymosan-induced arthritis. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:851-61 pubmed publisher
    ..systemic administration of guanethidine, a sympatholytic drug that inhibits catecholamine release, and nadolol, a beta-adrenergic receptor antagonist, reversed the effect of saclofen...
  4. Gao X, Hicks K, Neumann P, Patel T. Hypoxia inducible factors regulate the transcription of the sprouty2 gene and expression of the sprouty2 protein. PLoS ONE. 2017;12:e0171616 pubmed publisher
    ..HIFs are composed of an oxygen regulated alpha subunit (HIF1α or HIF2α) and a beta subunit (HIF1β)...
  5. Ajdic D, Pham V. Global transcriptional analysis of Streptococcus mutans sugar transporters using microarrays. J Bacteriol. 2007;189:5049-59 pubmed
    ..glucose, fructose, galactose, and mannose), disaccharides (sucrose, lactose, maltose, and trehalose), a beta-glucoside (cellobiose), oligosaccharides (raffinose, stachyose, and maltotriose), and a sugar alcohol (mannitol)...
  6. Kwon W, Rahman M, Lee J, Kim J, Yoon S, Park Y, et al. A comprehensive proteomic approach to identifying capacitation related proteins in boar spermatozoa. BMC Genomics. 2014;15:897 pubmed publisher
    ..PRDX5), Apolipoprotein A-I (APOA1), Mitochondrial Succinyl-CoA ligase [ADP-forming] subunit beta (SUCLA2), Acrosin-binding protein, Ropporin-1A, and Spermadhesin AWN that were enriched after-capacitation (>3-fold) by ..
  7. Saito Y, Nakamura K, Yoshida M, Sugiyama H, Ohe T, Kurokawa J, et al. Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker. PLoS ONE. 2015;10:e0138193 pubmed publisher
    ..The beating rate of HCN4-overexpressing mESC-CMs responded to ivabradine, an If inhibitor, and to isoproterenol, a beta-adrenergic receptor agonist...
  8. Iranpour S, Sabour S. Inverse association between caffeine intake and depressive symptoms in US adults: data from National Health and Nutrition Examination Survey (NHANES) 2005-2006. Psychiatry Res. 2019;271:732-739 pubmed publisher
  9. Eliakim Raz N, Robenshtok E, Shefet D, Gafter Gvili A, Vidal L, Paul M, et al. Empiric antibiotic coverage of atypical pathogens for community-acquired pneumonia in hospitalized adults. Cochrane Database Syst Rev. 2012;:CD004418 pubmed publisher
    ..The atypical antibiotic was administered as monotherapy in all but three studies. Only one study assessed a beta-lactam combined with a macrolide compared to the same beta-lactam...
  10. Pagel P, Boettcher B, De Vry D, Freed J, Iqbal Z. Moderate Aortic Valvular Insufficiency Invalidates Vortex Formation Time as an Index of Left Ventricular Filling Efficiency in Patients With Severe Degenerative Calcific Aortic Stenosis Undergoing Aortic Valve Replacement. J Cardiothorac Vasc Anesth. 2016;30:1260-5 pubmed publisher
    ..Moderate AI falsely elevates VFT in patients with severe AS undergoing AVR by partially inhibiting mitral valve opening. VFT may be an unreliable index of LV filling efficiency with competitive diastolic flow into the LV. ..
  11. Soimala T, Lübke Becker A, Schwarz S, Feßler A, Huber C, Semmler T, et al. Occurrence and molecular composition of methicillin-resistant Staphylococcus aureus isolated from ocular surfaces of horses presented with ophthalmologic disease. Vet Microbiol. 2018;222:1-6 pubmed publisher
    ..Moreover, all MRSA were positive for a beta-hemolysin converting phage carrying genes of the immune evasion cluster (IEC)...
  12. Chandhoke G, Shayegan B, Hotte S. Exogenous estrogen therapy, testicular cancer, and the male to female transgender population: a case report. J Med Case Rep. 2018;12:373 pubmed publisher
    ..Germ cell tumor markers revealed an alpha-fetoprotein of < 2.5 μg/L and a beta-human chorionic gonadotrophin of 2526 IU/L. Her lactate dehydrogenase was 5294 U/L...
  13. Bethke J, Avendaño Herrera R. Comparative genome analysis of two Streptococcus phocae subspecies provides novel insights into pathogenicity. Mar Genomics. 2017;31:53-61 pubmed publisher
    Streptococcus phocae is a beta-hemolytic, Gram-positive bacterium that was first isolated in Norway from clinical specimens of harbor seal (Phoca vitulina) affected by pneumonia or respiratory infection, and in 2005, this bacterium was ..
  14. Kittang B, Pettersen V, Oppegaard O, Skutlaberg D, Dale H, Wiker H, et al. Zoonotic necrotizing myositis caused by Streptococcus equi subsp. zooepidemicus in a farmer. BMC Infect Dis. 2017;17:147 pubmed publisher
    Streptococcus equi subsp. zooepidemicus is a beta-hemolytic group C streptococcus mainly causing infections in domesticated animals. Here we describe the first case of zoonotic necrotizing myositis caused by this bacterium...
  15. Drinkovic D, Morris A, Dyet K, Bakker S, Heffernan H. Plasmid-mediated AmpC beta-lactamase-producing Escherichia coli causing urinary tract infection in the Auckland community likely to be resistant to commonly prescribed antimicrobials. N Z Med J. 2015;128:50-9 pubmed
    ..A greater proportion of patients with community-acquired UTI caused by PMACBL-producing E. coli received a beta-lactam antimicrobial than patients with community-acquired UTI caused by other non-AmpC, non-ESBL-producing E...
  16. Rozenblyum E, Levy D, Allen U, Harvey E, Hebert D, Silverman E. Cytomegalovirus in pediatric systemic lupus erythematosus: prevalence and clinical manifestations. Lupus. 2015;24:730-5 pubmed publisher
    Cytomegalovirus (CMV) is a beta-herpesvirus and antibodies to this virus are common in patients with systemic lupus erythematosus (SLE). However, few studies have examined the relationship between CMV infection and SLE...
  17. Chams S, El Sayegh S, Hamdon M, Kumar S, Kulairi Z. Zumba-induced Takotsubo cardiomyopathy: a case report. J Med Case Rep. 2018;12:160 pubmed publisher
    ..after fulfilling all four of the Mayo Clinic's diagnostic criteria and was subsequently treated with a beta blocker, and angiotensin-converting enzyme inhibitor...
  18. Lachance D, Dhahri W, Drolet M, Roussel Ã, Gascon S, Sarrhini O, et al. Endurance training or beta-blockade can partially block the energy metabolism remodeling taking place in experimental chronic left ventricle volume overload. BMC Cardiovasc Disord. 2014;14:190 pubmed publisher
    ..AR rats (20 animals) were trained on a treadmill 5 times a week for 9 months and another group of rats received a beta-blockade treatment (carvedilol) for 6 months...
  19. Cagnina R, Ramos S, Marshall M, Wang G, Frazier C, Linden J. Adenosine A2B receptors are highly expressed on murine type II alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2009;297:L467-74 pubmed publisher
    ..The recent generation of an A(2B)R(-/-) mouse constructed with a beta-galactosidase (beta-gal) reporter gene under control of the endogenous promoter has provided a valuable tool to ..
  20. Marathe N, Janzon A, Kotsakis S, Flach C, Razavi M, Berglund F, et al. Functional metagenomics reveals a novel carbapenem-hydrolyzing mobile beta-lactamase from Indian river sediments contaminated with antibiotic production waste. Environ Int. 2018;112:279-286 pubmed publisher
    ..Two class A beta-lactamases, blaRSA1 and blaRSA2, were phylogenetically close to clinically important ESBLs ..
  21. Merkiel Pawłowska S, Chalcarz W. Gender differences and typical nutrition concerns of the diets of preschool children - the results of the first stage of an intervention study. BMC Pediatr. 2017;17:207 pubmed publisher
  22. Brook I. Spectrum and treatment of anaerobic infections. J Infect Chemother. 2016;22:1-13 pubmed publisher
    ..the carbapenems (imipenem, meropenem, doripenem, ertapenem), chloramphenicol, the combinations of a penicillin and a beta-lactamase inhibitors (ampicillin or ticarcillin plus clavulanate, amoxicillin plus sulbactam, piperacillin plus ..
  23. Barua C, Buragohain L, Rizavi H, Gogoi S, Rahman F, Siva B, et al. Effect of seeds of Entada phaseoloides on chronic restrain stress in mice. J Ayurveda Integr Med. 2019;: pubmed publisher
    ..MEEP altered endoplasmic reticulum stress in chronic restrain stressed mice; however, as an antidepressant it showed a weaker response. ..
  24. Cui C, Huang C, Liu K, Xu G, Yang J, Zhou Y, et al. Large-scale in silico identification of drugs exerting sex-specific effects in the heart. J Transl Med. 2018;16:236 pubmed publisher
    ..To validate our model in humans, we employed two Chinese cohorts, which showed that among patients taking a beta-receptor blocker (metoprolol), women reached significantly lower diastolic blood pressure than men...
  25. Turner P, Turner C, Watthanaworawit W, Carrara V, Cicelia N, Deglise C, et al. Respiratory virus surveillance in hospitalised pneumonia patients on the Thailand-Myanmar border. BMC Infect Dis. 2013;13:434 pubmed publisher
    ..002). IPD treatment was documented in 702/708 cases; all but one patient received antimicrobials, most commonly a beta-lactam (amoxicillin/ampicillin +/-gentamicin in 664/701, 94.7%)...
  26. Verhoven S, Groszek J, Fissell W, Seegmiller A, Colby J, Patel P, et al. Therapeutic drug monitoring of piperacillin and tazobactam by RP-HPLC of residual blood specimens. Clin Chim Acta. 2018;482:60-64 pubmed publisher
    ..currently no commercially available FDA-approved assay to measure piperacillin-tazobactam, very commonly used as a beta-lactam/beta-lactamase inhibitor combination antibiotic in the intensive care unit (ICU)...
  27. Hasni Ebou M, Singh Estivalet A, Launay J, Callebert J, Tronche F, Ferre P, et al. Glucocorticoids Inhibit Basal and Hormone-Induced Serotonin Synthesis in Pancreatic Beta Cells. PLoS ONE. 2016;11:e0149343 pubmed publisher
    ..serotonin synthesis was evaluated in vitro after treatment with GCs of either islets from CD1 mice or MIN6 cells, a beta-cell line...
  28. Tamir S, Paddock M, Darash Yahana Baram M, Holt S, Sohn Y, Agranat L, et al. Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease. Biochim Biophys Acta. 2015;1853:1294-315 pubmed publisher
    ..NAF-1), and the plant At-NEET uncovered a homodimer with a unique "NEET fold", as well as two distinct domains: a beta-cap and a 2Fe-2S cluster-binding domain...
  29. Hardy A, Prentice K, Froese S, Liu Y, Andrews G, Wheeler M. Zip4 mediated zinc influx stimulates insulin secretion in pancreatic beta cells. PLoS ONE. 2015;10:e0119136 pubmed publisher
    ..To define the role of Zip4 in-vivo, we generated a beta cell-specific knockout mouse model (Zip4BKO)...
  30. Tewari A, Kurup S, Baidya S, Barta J, Sharma B. Protective antibody and cytokine responses in mice following immunization with recombinant beta-tubulin and subsequent Trypanosoma evansi challenge. Parasit Vectors. 2015;8:580 pubmed publisher
    ..Immunization with recombinant beta (β)-tubulin protein induced a beta-tubulin specific humoral immune response of predominantly IgG2a isotype. Lethal challenge with T...
  31. Trehan A, Totadri S, Gautam V, Bansal D, Ray P. Invasive bacterial infections in a pediatric oncology unit in a tertiary care center. Indian J Cancer. 2014;51:428-31 pubmed publisher
    ..The combination of a beta-lactam/inhibitor covered 2/3rd of Gram-negative organisms...
  32. Pranzatelli M, Tate E, Allison T. Case-control, exploratory study of cerebrospinal fluid chemokines/cytokines and lymphocyte subsets in childhood Tourette syndrome with positive streptococcal markers. Cytokine. 2017;96:49-53 pubmed publisher
    ..Three subjects with TS (60%) had positive throat cultures for Group A beta-hemolytic strep, five had elevated anti-deoxyribonuclease-B titers (mean=444), and 4 (80%) had elevated anti-..
  33. Hayflick S, Kruer M, Gregory A, Haack T, Kurian M, Houlden H, et al. ?-Propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation. Brain. 2013;136:1708-17 pubmed publisher
    ..All patients harboured de novo mutations in WDR45, encoding a beta-propeller protein postulated to play a role in autophagy...
  34. Dimondi V, Townsend M, Drew R. Risk factors associated with unfavorable short-term treatment outcome in patients with documented Pseudomonas aeruginosa infection. Int J Clin Pharm. 2015;37:348-54 pubmed publisher
    ..Combination therapy primarily consisted of a beta-lactam plus ciprofloxacin in both unfavorable (10 %) and not-unfavorable (20 %) outcome groups...
  35. Daniel A, Rapose A. The evaluation of Clostridium difficile infection (CDI) in a community hospital. J Infect Public Health. 2015;8:155-60 pubmed publisher
    ..Patients who had taken antibiotics in the previous six months constituted 74% of the total study population. A beta-lactam alone or in combination with other antibiotics was prescribed in 48%, quinolones in 13% and clindamycin in ..
  36. Wurtman R. Biomarkers in the diagnosis and management of Alzheimer's disease. Metabolism. 2015;64:S47-50 pubmed publisher
  37. Di Muzio F, Barucco M, Guerriero F. Diagnosis and treatment of acute pharyngitis/tonsillitis: a preliminary observational study in General Medicine. Eur Rev Med Pharmacol Sci. 2016;20:4950-4954 pubmed
    ..study is intended to demonstrate the usefulness of the rapid test (RAD: Rapid antigen detection) against group A beta-hemolytic streptococcus (GABHS) in everyday clinical practice to identify individuals with acute streptococcal ..
  38. González Mariscal I, Montoro R, Doyle M, Liu Q, Rouse M, O Connell J, et al. Absence of cannabinoid 1 receptor in beta cells protects against high-fat/high-sugar diet-induced beta cell dysfunction and inflammation in murine islets. Diabetologia. 2018;61:1470-1483 pubmed publisher
    ..We generated a beta cell specific Cnr1 (CB1R) knockout mouse (β-CB1R-/-) to study the long-term consequences of CB1R ..
  39. Aikawa N, Suzuki Y, Takaba K. A Simple Protocol for the Myocardial Differentiation of Human iPS Cells. Biol Pharm Bull. 2015;38:1070-5 pubmed publisher
    ..delayed rectifier potassium current (Iks) channel blocker, chromanol 293B, and was increased by treatment with a beta-receptor agonist, isoproterenol...
  40. Brandenburg V, Rocca H, Marx N. [Sacubitril / Valsartan in patients with diabetes and heart failure]. Dtsch Med Wochenschr. 2016;141:1647-1649 pubmed
    ..for Sacubitril / Valsartan in HFREF patients who remain symptomatic despite optimal treatment with ACE-I, a beta-blocker, and a mineralocorticoid receptor antagonist...
  41. Pokorney S, Mi X, Hammill B, Allen LaPointe N, Curtis L, Al Khatib S. Use of Antiarrhythmic Medications in Medicare Part D Patients With an Implantable Cardioverter-Defibrillator and Ventricular Tachycardia. Am J Cardiol. 2017;119:1401-1406 pubmed publisher
    ..Of the 2007 cohort, 1,380 (59%) patients were on a beta blocker, and 484 (20.7%) were on an antiarrhythmic medication (70% amiodarone and 20% sotalol)...
  42. Wang X, Zhou B, Hu W, Zhao Q, Lin Z. Formation of active inclusion bodies induced by hydrophobic self-assembling peptide GFIL8. Microb Cell Fact. 2015;14:88 pubmed publisher
    ..More recently, we have demonstrated that three amphipathic self-assembling peptides, an alpha helical peptide 18A, a beta-strand peptide ELK16, and a surfactant-like peptide L6KD, have properties that induce target proteins into active ..
  43. Davari K, Nowroozi J, Hosseini F, Sepahy A, Mirzaie S. Structure-based virtual screening to identify the beta-lactamase CTX-M-9 inhibitors: An in silico effort to overcome antibiotic resistance in E. coli. Comput Biol Chem. 2017;67:174-181 pubmed publisher
    ..Among different and diverse resistance targets, we chose a class A beta lactamase, CTX-M-9, with the aim of identifying new chemical entities to be used for further rational drug design...
  44. Hariri G, Tankovic J, Boelle P, Dubée V, Leblanc G, Pichereau C, et al. Are third-generation cephalosporins unavoidable for empirical therapy of community-acquired pneumonia in adult patients who require ICU admission? A retrospective study. Ann Intensive Care. 2017;7:35 pubmed publisher
    ..Among 267 patients with microbiologically documented CAP (68%), 241 received a beta-lactam as definitive therapy, and of those, 3CGs were chosen for 43 patients (18%)...
  45. Sharma R, Francois D, Hammerschlag M. New Antimicrobial Agents for the Treatment of Staphylococcal Infections in Children. Pediatr Clin North Am. 2017;64:1369-1387 pubmed publisher
    ..Ceftaroline, a beta-lactam antibiotic with activity against MRSA, has been approved for treatment of community-acquired bacterial ..
  46. Schweizer R, Godet G, Petit P, Elia J, Guette P, Finet G, et al. Adherence of French cardiologists to guidelines for non-cardiac surgery. Anaesth Crit Care Pain Med. 2016;35:249-53 pubmed publisher
    ..disease, 59/73 (81%) received a statin, 60/73 (82%) received an antiplatelet agent, and 38/73 (52%) received a beta-blocker...
  47. Trushin V, Englender M. Clinical value of antistreptolysin O levels in adult patients with tonsillitis: report I. Eur Arch Otorhinolaryngol. 2017;274:2035-2039 pubmed publisher
    To assess the clinical value of antistreptolysin O (ASO) level in adult patients with acute tonsillitis of group A beta-hemolytic streptococcus (GABHS) etiology and its interaction with the Centor score and throat cultures data...
  48. Mann S. Redefining beta-blocker use in hypertension: selecting the right beta-blocker and the right patient. J Am Soc Hypertens. 2017;11:54-65 pubmed publisher
    ..In the absence of comorbidities for which a beta-blocker is indicated, beta-blockers would not seem to be the preferred treatment for patients with either sodium/..
  49. Zhou F, Xu X, Wu J, Wang D, Wang J. NF-?B controls four genes encoding core enzymes of tricarboxylic acid cycle. Gene. 2017;621:12-20 pubmed publisher
    ..that four genes that encode core enzymes of the tricarboxylic acid (TCA) cycle, including IDH1, IDH3A, ACO2, and SUCLA2, were multiply bound by this transcription factor...
  50. Johari Doha F, Rahmani S, Rikhtechi P, Rasaneh S, Sheikholislam Z, Shahhosseini S. Development of DOTA-Rituximab to be Labeled with 90Y for Radioimmunotherapy of B-cell Non-Hodgkin Lymphoma. Iran J Pharm Res. 2017;16:619-629 pubmed
    ..radiosensitive, low grade NHL that has relapsed or refractory to standard therapy is treated by RIT in which a beta-emitting radionuclide coupled to anti-CD20 antibody...
  51. Bergman J, Lutke L, Gans R, Addor M, Barisic I, Cavero Carbonell C, et al. Beta-Blocker Use in Pregnancy and Risk of Specific Congenital Anomalies: A European Case-Malformed Control Study. Drug Saf. 2018;41:415-427 pubmed publisher
    ..Odds ratios of exposure to any beta-blocker or to a beta-blocker subgroup were calculated for each signal anomaly compared with two control groups (non-chromosomal, non-..
  52. Matilainen S, Isohanni P, Euro L, Lonnqvist T, Pihko H, Kivela T, et al. Mitochondrial encephalomyopathy and retinoblastoma explained by compound heterozygosity of SUCLA2 point mutation and 13q14 deletion. Eur J Hum Genet. 2015;23:325-30 pubmed publisher
    Mutations in SUCLA2, encoding the ß-subunit of succinyl-CoA synthetase of Krebs cycle, are one cause of mitochondrial DNA depletion syndrome...
  53. Mojadidi M, Galeas J, Goodman Meza D, Eshtehardi P, Msaouel P, Kelesidis I, et al. Thrombocytopaenia as a Prognostic Indicator in Heart Failure with Reduced Ejection Fraction. Heart Lung Circ. 2016;25:568-75 pubmed publisher
    ..All patients were on medical therapy with a beta-blocker and an angiotensin-converting enzyme inhibitor...
  54. Rubin I, Doebeli M. Rethinking the evolution of specialization: A model for the evolution of phenotypic heterogeneity. J Theor Biol. 2017;435:248-264 pubmed publisher
    ..Rather than assume a Gaussian phenotype distribution, we use a Beta distribution that is capable of describing genotypes that manifest as individuals with two distinct phenotypes...
  55. Gattarello S. What Is New in Antibiotic Therapy in Community-Acquired Pneumonia? An Evidence-Based Approach Focusing on Combined Therapy. Curr Infect Dis Rep. 2015;17:501 pubmed publisher
    ..with a lower mortality in case of severe CAP that requires intensive care unit (ICU) admission, especially when a beta-lactam-macrolide association is delivered...
  56. Jamieson C, Mills K, Lui C, Semaan C, Molloy M, Sharma M, et al. Characterization of a beta-catenin nuclear localization defect in MCF-7 breast cancer cells. Exp Cell Res. 2016;341:196-206 pubmed publisher
    ..We propose that in MCF-7 and perhaps other breast cancer cells, beta-catenin may contribute to cytoplasmic functions such as ER-golgi transport, in addition to its transactivation role in the nucleus. ..
  57. Wijesekara N, Kaur A, Westwell Roper C, Nackiewicz D, Soukhatcheva G, Hayden M, et al. ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice. Diabetologia. 2016;59:1242-6 pubmed publisher
    ..a pathological feature of type 2 diabetes, forms from the aggregation of islet amyloid polypeptide (IAPP), a beta cell peptide that is produced and co-secreted with insulin...
  58. Ormeño F, Barrientos C, Ramirez S, Ponce I, Valenzuela L, Sepúlveda S, et al. Expression and the Peculiar Enzymatic Behavior of the Trypanosoma cruzi NTH1 DNA Glycosylase. PLoS ONE. 2016;11:e0157270 pubmed publisher
    ..unable to eliminate thymine glycol derivatives but that recognizes and cuts an AP site, most probably by a beta-elimination mechanism. We cannot discard that TcNTH1 presents DNA glycosylase activity on other DNA base lesions...
  59. Wurtman R. Synapse formation in the brain can be enhanced by co-administering three specific nutrients. Eur J Pharmacol. 2017;817:20-21 pubmed publisher
    ..The UTP in neurons can also be converted to cytidylyl triphosphate, CTP, the intermediate utilized in the Kennedy Cycle. ..
  60. Bronzi D, Licata F, Li Volsi G. Noradrenergic modulation of glutamate-induced excitatory responses in single neurons of the red nucleus: an electrophysiological study. Neuroscience. 2015;300:360-9 pubmed publisher
    ..Application of isoproterenol, a beta adrenoceptor agonist, either enhanced or depressed neuronal responses to Glu in a high percentage (86%) of the ..
  61. Pospiech T, Jaussaud J, Sacher F, Hooks D, Haïssaguerre M, Douard H. Characterization of repolarization in Brugada syndrome patients during exercise testing: Dynamic angle evaluation. J Electrocardiol. 2015;48:879-86 pubmed publisher
    ..We assessed this criterion during exercise comparing BrS (46 patients) and IRBBB (17 patients). A beta angle was measured from lead V1 between the upslope of S-wave and the downslope of the r'-wave...
  62. Suzuki T, Tani Y, Ogasawara K. Behavioral Analysis of Visitors to a Medical Institution's Website Using Markov Chain Monte Carlo Methods. J Med Internet Res. 2016;18:e199 pubmed publisher
    ..Using this model, we determined a beta value and generated a posterior distribution...
  63. Kroiss S, Famulare M, Lyons H, McCarthy K, Mercer L, Chabot Couture G. Evaluating cessation of the type 2 oral polio vaccine by modeling pre- and post-cessation detection rates. Vaccine. 2017;35:5674-5681 pubmed publisher
    ..We modeled the peak and decay of SL2 prevalence following mass vaccination events using a beta-binomial model for the detection rate, and a Ricker function for the temporal dependence...
  64. Mondo S, Lastovetsky O, Gaspar M, Schwardt N, Barber C, Riley R, et al. Bacterial endosymbionts influence host sexuality and reveal reproductive genes of early divergent fungi. Nat Commun. 2017;8:1843 pubmed publisher
    ..Here, we explore this prediction in the mutualism between the fungus Rhizopus microsporus (Rm, Mucoromycotina) and a beta-proteobacterium Burkholderia, which controls host asexual reproduction...
  65. Deming J, Shin J, Lim K, Lee E, Van Craenenbroeck K, CRAFT C. Dopamine receptor D4 internalization requires a beta-arrestin and a visual arrestin. Cell Signal. 2015;27:2002-13 pubmed publisher
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    ..The results support the concept that fuel excess can drive obesity and diabetes via hyperinsulinaemia, and that an islet beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion. ..
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    ..A single dose of MB12066 within the dose range of 10-400 mg and multiple doses of 100 and 200 mg of MB12066 were safe and tolerated in healthy subjects. Additionally, MB12066 was mainly eliminated through metabolism in humans...
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