Gene Symbol: STX12
Description: syntaxin 12
Alias: STX13, STX14, syntaxin-12
Species: human
Products:     STX12

Top Publications

  1. Advani R, Bae H, Bock J, Chao D, Doung Y, Prekeris R, et al. Seven novel mammalian SNARE proteins localize to distinct membrane compartments. J Biol Chem. 1998;273:10317-24 pubmed
    ..Our studies support the hypothesis that evolutionary radiation of these two gene families gave rise to sets of proteins whose differential expression and combinatorial associations define and organize the membrane compartments of cells. ..
  2. Prekeris R, Klumperman J, Chen Y, Scheller R. Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. J Cell Biol. 1998;143:957-71 pubmed
    ..These results support a role for syntaxin 13 in membrane fusion events during the recycling of plasma membrane proteins. ..
  3. Tang B, Tan A, Lim L, Lee S, Low D, Hong W. Syntaxin 12, a member of the syntaxin family localized to the endosome. J Biol Chem. 1998;273:6944-50 pubmed
    ..The cDNA we have cloned apparently corresponded to three previously described expressed sequence tags named as syntaxins 12, 13, and 14, respectively. We therefore propose to retain the name syntaxin 12 for this protein.
  4. McBride H, Rybin V, Murphy C, Giner A, Teasdale R, Zerial M. Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13. Cell. 1999;98:377-86 pubmed
    ..We propose a novel mechanism whereby oligomeric EEA1 and NSF mediate the local activation of syntaxin 13 upon membrane tethering and, by analogy with viral fusion proteins, coordinate the assembly of a fusion pore. ..
  5. Huang L, Kuo Y, Gitschier J. The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency. Nat Genet. 1999;23:329-32 pubmed
    ..Whereas the mocha and pearl SPD mutants have defects in Ap-3, our findings suggest that pa SPD mutants are defective in a more downstream event of vesicle-trafficking: namely, vesicle-docking and fusion. ..
  6. Moriyama K, Bonifacino J. Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles. Traffic. 2002;3:666-77 pubmed
    ..These observations indicate that pallidin is a subunit of a novel multi-protein complex involved in the biogenesis of lysosome-related organelles. ..
  7. Hirling H, Steiner P, Chaperon C, Marsault R, Regazzi R, Catsicas S. Syntaxin 13 is a developmentally regulated SNARE involved in neurite outgrowth and endosomal trafficking. Eur J Neurosci. 2000;12:1913-23 pubmed
    ..The data suggest that a syntaxin 13-dependent endocytic trafficking step plays a limiting role in membrane expansion during neuronal development. ..
  8. Koike S, Jahn R. SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors. Nat Commun. 2019;10:1608 pubmed publisher
    ..Here we report that vesicles containing the Q-SNAREs syntaxin 13 (Stx13) and syntaxin 6 (Stx6) together are targeted to a different endosomal compartment than vesicles containing only ..
  9. Mahanty S, Ravichandran K, Chitirala P, Prabha J, Jani R, Setty S. Rab9A is required for delivery of cargo from recycling endosomes to melanosomes. Pigment Cell Melanoma Res. 2016;29:43-59 pubmed publisher
    ..silencing of Rab9A, Rab38/32 or its effector VARP, or BLOC-3-deficiency in melanocytes decreased the length of STX13-positive recycling endosomal tubules and targeted the SNARE to lysosomes...

More Information


  1. Wang H, Jiang Y, Lu M, Sun B, Qiao X, Xue D, et al. STX12 lncRNA/miR-148a/SMAD5 participate in the regulation of pancreatic stellate cell activation through a mechanism involving competing endogenous RNA. Pancreatology. 2017;17:237-246 pubmed publisher
    ..In addition, activated rat PSCs were transfected with a small interfering RNA (siRNA) targeting the syntaxin-12 (STX12) lncRNA. Then, the expression of STX12, miR-148a and miR-130b were examined by RT-PCR...
  2. Falcon Perez J, Dell Angelica E. The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis. Pigment Cell Res. 2002;15:82-6 pubmed
    ..As SNARE proteins mediate fusion of intracellular membranes, pallidin may play a role in membrane fusion events required for melanosome biogenesis. ..
  3. Steiner P, Sarria J, Glauser L, Magnin S, Catsicas S, Hirling H. Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD. J Cell Biol. 2002;157:1197-209 pubmed
    ..In summary, NEEP21 is a neuronal protein that is localized to the early endosomal pathway and is necessary for correct receptor recycling in neurons. ..
  4. Ghiani C, Starcevic M, Rodriguez Fernandez I, Nazarian R, Cheli V, Chan L, et al. The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth. Mol Psychiatry. 2010;15:115, 204-15 pubmed publisher
  5. Kean M, Williams K, Skalski M, Myers D, Burtnik A, Foster D, et al. VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. J Cell Sci. 2009;122:4089-98 pubmed publisher
    ..The results reveal the importance of VAMP3, syntaxin-13 and SNAP23 in the trafficking of MMP during degradation of ECM substrates and subsequent cellular invasion. ..
  6. Minakami R, Kato A, Sugiyama H. Interaction of Vesl-1L/Homer 1c with syntaxin 13. Biochem Biophys Res Commun. 2000;272:466-71 pubmed
    ..We thus propose that the association of Vesl-1L with syntaxin 13 plays a role in the translocation of Vesl-1L to the intracellular organelles. ..
  7. Sun W, Yan Q, Vida T, Bean A. Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex. J Cell Biol. 2003;162:125-37 pubmed
    ..These data suggest that SNAP-25 is a receptor for Hrs on early endosomal membranes and that the binding of Hrs to SNAP-25 on endosomal membranes inhibits formation of a SNARE complex required for homotypic endosome fusion. ..
  8. Lu Y, Zhang Z, Sun D, Sweeney S, Gao F. Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation. Mol Cell. 2013;52:264-71 pubmed publisher
    ..Knockdown of syntaxin 13 (STX13) or its binding partner Vti1a in mammalian cells caused LC3-positive puncta to accumulate and blocks autophagic ..
  9. Williams K, Coppolino M. SNARE-dependent interaction of Src, EGFR and ?1 integrin regulates invadopodia formation and tumor cell invasion. J Cell Sci. 2014;127:1712-25 pubmed publisher
    ..Src, EGFR and ?1 integrin is dependent upon membrane traffic that is mediated by syntaxin13 (officially known as STX12) and SNAP23; a similar dependence on these two SNARE proteins was observed for invadopodium-based matrix ..
  10. Jani R, Purushothaman L, Rani S, Bergam P, Setty S. STX13 regulates cargo delivery from recycling endosomes during melanosome biogenesis. J Cell Sci. 2015;128:3263-76 pubmed publisher
    ..We found that depletion of syntaxin 13 (STX13, also known as STX12), a recycling endosomal Qa-SNARE, inhibits pigment granule maturation in melanocytes by ..
  11. Kuster A, Nola S, Dingli F, Vacca B, Gauchy C, Beaujouan J, et al. The Q-soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Q-SNARE) SNAP-47 Regulates Trafficking of Selected Vesicle-associated Membrane Proteins (VAMPs). J Biol Chem. 2015;290:28056-69 pubmed publisher
    ..We conclude that SNAP-47 plays a role in the proper localization and function of a subset of VAMPs likely via regulation of their transport through the early secretory pathway. ..
  12. Steegmaier M, Yang B, Yoo J, Huang B, Shen M, Yu S, et al. Three novel proteins of the syntaxin/SNAP-25 family. J Biol Chem. 1998;273:34171-9 pubmed
    ..SNAP-29 does not contain a predicted membrane anchor characteristic of other SNAREs. In vitro studies established that SNAP-29 is capable of binding to a broad range of syntaxins. ..
  13. Bared S, Buechler C, Boettcher A, Dayoub R, Sigruener A, Grandl M, et al. Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. Mol Biol Cell. 2004;15:5399-407 pubmed
    ..It is concluded that ABCA1 forms a complex with syntaxin 13 and flotillin-1, residing at the plasma membrane and in phagosomes that are partially located in raft microdomains. ..