Gene Symbol: stratifin
Description: stratifin
Alias: YWHAS, 14-3-3 protein sigma, epithelial cell marker protein 1
Species: human
Products:     stratifin

Top Publications

  1. Lam E, Kilani R, Li Y, Tredget E, Ghahary A. Stratifin-induced matrix metalloproteinase-1 in fibroblast is mediated by c-fos and p38 mitogen-activated protein kinase activation. J Invest Dermatol. 2005;125:230-8 pubmed
    Previously, we have demonstrated that keratinocyte releasable stratifin, also known as 14-3-3 sigma protein, stimulates matrix metalloproteinase (MMP)-1 expression in dermal fibroblasts...
  2. Zurita M, Lara P, del Moral R, Torres B, Linares Fernández J, Arrabal S, et al. Hypermethylated 14-3-3-sigma and ESR1 gene promoters in serum as candidate biomarkers for the diagnosis and treatment efficacy of breast cancer metastasis. BMC Cancer. 2010;10:217 pubmed publisher
    ..association between clinical extension of breast cancer and methylation status of estrogen receptor1 (ESR1) and stratifin (14-3-3-sigma) gene promoters in disease-free and metastatic breast cancer patients...
  3. Chan T, Hermeking H, Lengauer C, Kinzler K, Vogelstein B. 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature. 1999;401:616-20 pubmed
    ..These results may indicate a mechanism for maintaining the G2 checkpoint and preventing mitotic death. ..
  4. Laronga C, Yang H, Neal C, Lee M. Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression. J Biol Chem. 2000;275:23106-12 pubmed
    ..These findings define 14-3-3 sigma as a negative regulator of the cell cycle progression and suggest that it has an important function in preventing breast tumor cell growth. ..
  5. Nakayama H, Sano T, Motegi A, Oyama T, Nakajima T. Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma. Pathol Int. 2005;55:707-15 pubmed
  6. Suzuki T, Urano T, Miki Y, Moriya T, Akahira J, Ishida T, et al. Nuclear cyclin B1 in human breast carcinoma as a potent prognostic factor. Cancer Sci. 2007;98:644-51 pubmed
    ..Nuclear cyclin B1-positive breast carcinoma is resistant to adjuvant therapy, and nuclear cyclin B1 immunoreactivity is a potent prognostic factor in breast carcinoma patients. ..
  7. Wilker E, van Vugt M, Artim S, Huang P, Petersen C, Reinhardt H, et al. 14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature. 2007;446:329-32 pubmed
  8. Oshiro M, Futscher B, Lisberg A, Wozniak R, Klimecki W, Domann F, et al. Epigenetic regulation of the cell type-specific gene 14-3-3sigma. Neoplasia. 2005;7:799-808 pubmed
    ..These findings extend the spectrum of cell type-specific genes controlled, partly, by normal epigenetic mechanisms, and suggest that this subset of genes may represent important targets of epigenetic dysregulation in human cancer. ..
  9. Zhou W, Tang F, Xu J, Wu X, Feng Z, Li H, et al. Aberrant upregulation of 14-3-3? expression serves as an inferior prognostic biomarker for gastric cancer. BMC Cancer. 2011;11:397 pubmed publisher
    ..Thus, overexpression of 14-3-3? identifies patients at high risk and is a novel therapeutic molecular target for this tumor. ..

More Information


  1. Han B, Xie H, Chen Q, Zhang J. Sensitizing hormone-refractory prostate cancer cells to drug treatment by targeting 14-3-3sigma. Mol Cancer Ther. 2006;5:903-12 pubmed
    ..Based on these studies, we propose that therapeutic intervention targeting 14-3-3sigma may be useful for sensitizing hormone-refractory prostate cancers to chemotherapy by both G2-M checkpoint abrogation and apoptosis enhancement. ..
  2. Wilker E, Grant R, Artim S, Yaffe M. A structural basis for 14-3-3sigma functional specificity. J Biol Chem. 2005;280:18891-8 pubmed
  3. Lodygin D, Diebold J, Hermeking H. Prostate cancer is characterized by epigenetic silencing of 14-3-3sigma expression. Oncogene. 2004;23:9034-41 pubmed
  4. Sano T, Shimooka H, Weixa P, Segawa A, Jian Z, Motegi A, et al. Immunohistochemical expression of 14-3-3 sigma protein in various histological subtypes of uterine cervical cancers. Pathol Int. 2004;54:743-50 pubmed
    ..These observations are consistent with the hypothesis that inactivation of either 14-3-3sigma or p16 has an effect equivalent to the expression of E6 and E7 oncoproteins of HPV. ..
  5. Ghahary A, Karimi Busheri F, Marcoux Y, Li Y, Tredget E, Taghi Kilani R, et al. Keratinocyte-releasable stratifin functions as a potent collagenase-stimulating factor in fibroblasts. J Invest Dermatol. 2004;122:1188-97 pubmed
    ..peptide mapping, a keratinocyte-derived collagenase-stimulating factor turned out to be a releasable form of stratifin, also known as 14-3-3 sigma protein...
  6. Satoh J, Tabunoki H, Nanri Y, Arima K, Yamamura T. Human astrocytes express 14-3-3 sigma in response to oxidative and DNA-damaging stresses. Neurosci Res. 2006;56:61-72 pubmed
    ..These observations suggest that 14-3-3sigma might serve as a marker of oxidative and DNA-damaging stresses inducing the mitotic checkpoint dysfunction in reactive astrocytes under pathological conditions. ..
  7. Nakajima T, Shimooka H, Weixa P, Segawa A, Motegi A, Jian Z, et al. Immunohistochemical demonstration of 14-3-3 sigma protein in normal human tissues and lung cancers, and the preponderance of its strong expression in epithelial cells of squamous cell lineage. Pathol Int. 2003;53:353-60 pubmed
  8. Li Z, Dong Z, Myer D, Yip Schneider M, Liu J, Cui P, et al. Role of 14-3-3? in poor prognosis and in radiation and drug resistance of human pancreatic cancers. BMC Cancer. 2010;10:598 pubmed publisher
    ..Thus, 14-3-3? may serve as a prognosis marker predicting survival of pancreatic cancer patients and guide the clinical treatment of these patients. ..
  9. Urano T, Saito T, Tsukui T, Fujita M, Hosoi T, Muramatsu M, et al. Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth. Nature. 2002;417:871-5 pubmed
    ..These data provide an insight into the cell-cycle machinery and tumorigenesis of breast cancer by identifying 14-3-3 sigma as a target for proteolysis by Efp, leading to cell proliferation. ..
  10. Prasad G, Valverius E, McDuffie E, Cooper H. Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells. Cell Growth Differ. 1992;3:507-13 pubmed
    ..HME1 therefore appears to be a cellular differentiation marker that may be down-regulated during neoplastic transformation. ..
  11. Leffers H, Madsen P, Rasmussen H, Honore B, Andersen A, Walbum E, et al. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. J Mol Biol. 1993;231:982-98 pubmed
    ..masses ranging between 30,000 and 31,100 (isoelectric focussing sample spot proteins 9109 (epithelial marker stratifin), 9124, 9125, 9126 and 9231 in the master two-dimensional gel database of human keratinocyte proteins) that ..
  12. Schumacher B, Mondry J, Thiel P, Weyand M, Ottmann C. Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer. FEBS Lett. 2010;584:1443-8 pubmed publisher
    ..The structure exhibits a potential binding site for small molecules that could stabilize the p53/14-3-3 protein complex suggesting the possibility for therapeutic intervention. ..
  13. Ide M, Saito K, Tsutsumi S, Tsuboi K, Yamaguchi S, Asao T, et al. Over-expression of 14-3-3sigma in budding colorectal cancer cells modulates cell migration in the presence of tenascin-C. Oncol Rep. 2007;18:1451-6 pubmed
    ..001). We concluded that the expression of 14-3-3sigma in the invasive area modulates tumor cell migration in certain types of colorectal cancer and thus facilitates tumor progression. ..
  14. Radhakrishnan V, Jensen T, Cui H, Futscher B, Martinez J. Hypomethylation of the 14-3-3? promoter leads to increased expression in non-small cell lung cancer. Genes Chromosomes Cancer. 2011;50:830-6 pubmed publisher
    ..And also no mutations were found in 14-3-3? gene. Overall, our data suggest that misregulated expression of 14-3-3? gene may be due to altered methylation status. © 2011 Wiley-Liss, Inc. ..
  15. Chavez Munoz C, Morse J, Kilani R, Ghahary A. Primary human keratinocytes externalize stratifin protein via exosomes. J Cell Biochem. 2008;104:2165-73 pubmed publisher
    Although, stratifin (SFN) is externalized by keratinocytes and stimulates the expression of matrix metalloproteinase-1 (MMP-1) in fibroblasts, its mechanism of externalization is not known...
  16. Neupane D, Korc M. 14-3-3sigma Modulates pancreatic cancer cell survival and invasiveness. Clin Cancer Res. 2008;14:7614-23 pubmed publisher
    ..Therefore, strategies aimed at suppressing 14-3-3sigma expression and function may have a therapeutic benefit in subgroups of patients with PDAC. ..
  17. Ito K, Suzuki T, Akahira J, Sakuma M, Saitou S, Okamoto S, et al. 14-3-3sigma in endometrial cancer--a possible prognostic marker in early-stage cancer. Clin Cancer Res. 2005;11:7384-91 pubmed
    ..In addition, results of 14-3-3sigma immunohistochemistry in the early stage of endometrial carcinoma could contribute to planning postoperative follow-up and adjuvant therapy. ..
  18. Yi B, Tan S, Tang C, Huang W, Cheng A, Li C, et al. Inactivation of 14-3-3 sigma by promoter methylation correlates with metastasis in nasopharyngeal carcinoma. J Cell Biochem. 2009;106:858-66 pubmed publisher
    ..Our data are the first to show that 14-3-3 sigma is frequently inactivated by promoter methylation in NPC and this aberrant methylation correlates with lymph node and distant metastasis. ..
  19. Perathoner A, Pirkebner D, Brandacher G, Spizzo G, Stadlmann S, Obrist P, et al. 14-3-3sigma expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients. Clin Cancer Res. 2005;11:3274-9 pubmed
    ..Thus, targeting 14-3-3sigma might be a new therapeutic strategy in colorectal carcinoma. ..
  20. Hermeking H, Lengauer C, Polyak K, He T, Zhang L, Thiagalingam S, et al. 14-3-3sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell. 1997;1:3-11 pubmed
  21. Samuel T, Weber H, Rauch P, Verdoodt B, Eppel J, McShea A, et al. The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax. J Biol Chem. 2001;276:45201-6 pubmed
    ..In conclusion, final sigma not only enforces the p53-dependent G(2) arrest but also delays the apoptotic signal transduction. ..
  22. Ghahary A, Marcoux Y, Karimi Busheri F, Li Y, Tredget E, Kilani R, et al. Differentiated keratinocyte-releasable stratifin (14-3-3 sigma) stimulates MMP-1 expression in dermal fibroblasts. J Invest Dermatol. 2005;124:170-7 pubmed
    ..identified KDAF as being the keratinocyte-releasable 14-3-3 sigma (14-3-3sigma) protein, which is also known as stratifin. In this study, we hypothesize that differentiated, but not proliferating, keratinocytes are the primary source ..
  23. Cheng L, Pan C, Zhang J, Zhang S, Kinch M, Li L, et al. Loss of 14-3-3sigma in prostate cancer and its precursors. Clin Cancer Res. 2004;10:3064-8 pubmed
    ..The sigma isoform (also called HME-1 or stratifin) is expressed in epithelial cells...
  24. Akahira J, Sugihashi Y, Suzuki T, Ito K, Niikura H, Moriya T, et al. Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation. Clin Cancer Res. 2004;10:2687-93 pubmed
    ..0058). Our findings suggest that 14-3-3 sigma is inactivated mainly by aberrant DNA methylation and that it may play an important role in the pathogenesis of epithelial ovarian cancer. ..
  25. Ito Y, Miyoshi E, Uda E, Yoshida H, Uruno T, Takamura Y, et al. 14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid. Cancer Lett. 2003;200:161-6 pubmed
    ..These results suggest that 14-3-3 sigma plays a constitutive role in papillary carcinoma rather than acting as a cell cycle regulator, whereas it is not required for the occurrence and development of follicular tumor. ..
  26. Bhatia K, Siraj A, Hussain A, Bu R, Gutierrez M. The tumor suppressor gene 14-3-3 sigma is commonly methylated in normal and malignant lymphoid cells. Cancer Epidemiol Biomarkers Prev. 2003;12:165-9 pubmed
    14-3-3 sigma/Stratifin was first identified as an epithelial cell antigen (HME-1) exclusively expressed in epithelia...
  27. Mhawech P. 14-3-3 proteins--an update. Cell Res. 2005;15:228-36 pubmed
    ..Gene silencing of 14-3-3sigma by CpG methylation has been found in many human cancer types. This suggests that therapy-targeting 14-3-3sigma may be beneficial for future cancer treatment. ..
  28. Martínez Galán J, Torres B, del Moral R, Muñoz Gámez J, Martín Oliva D, Villalobos M, et al. Quantitative detection of methylated ESR1 and 14-3-3-sigma gene promoters in serum as candidate biomarkers for diagnosis of breast cancer and evaluation of treatment efficacy. Cancer Biol Ther. 2008;7:958-65 pubmed
    ..Although numerous issues remain to be resolved, the quantitative measurement of circulating methylated DNA remains a promising tool for cancer risk assessment. ..
  29. Yang H, Wen Y, Lin Y, Pham L, Su C, Yang H, et al. Roles for negative cell regulator 14-3-3sigma in control of MDM2 activities. Oncogene. 2007;26:7355-62 pubmed
    ..Also, 14-3-3sigma blocks MDM2-mediated retinoblastoma degradation and p53 NEDDylation. Our results provide evidence that 14-3-3sigma is a pivotal MDM2 regulator involved in blocking a variety of activities of MDM2. ..
  30. Ravi D, Chen Y, Karia B, Brown A, Gu T, Li J, et al. 14-3-3 ? expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis. PLoS ONE. 2011;6:e15864 pubmed publisher
    ..Although a direct link between O? insensitivity and metastasis was not determined, this investigation showed that an O? insensitive phenotype in cancer cells to correlate with metastatic tumor progression. ..
  31. Yang H, Wen Y, Chen C, Lozano G, Lee M. 14-3-3 sigma positively regulates p53 and suppresses tumor growth. Mol Cell Biol. 2003;23:7096-107 pubmed
    ..These results defined an important p53 regulatory loop and suggested that 14-3-3 sigma expression can be considered for therapeutic intervention in cancers. ..
  32. Li Y, Lin X, Kilani R, Jones J, Ghahary A. 14-3-3 sigma isoform interacts with the cytoplasmic domain of the transmembrane BP180 in keratinocytes. J Cell Physiol. 2007;212:675-81 pubmed
    ..The protein 14-3-3 sigma, also known as stratifin and a marker for epithelial cells, is a member of a highly conserved small acidic 14-3-3 protein family ..
  33. Oh S, Komine S, Warabi E, Akiyama K, Ishii A, Ishige K, et al. Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles. Sci Rep. 2017;7:12902 pubmed publisher
    ..This in turn leads to enhanced exercise endurance capacity. These results provide new insights into SFN-induced upregulation of Nrf2 and its role in improving exercise performance. ..
  34. Okumura T, Ikeda K, Ujihira T, Okamoto K, Horie Inoue K, Takeda S, et al. Proteasome 26S subunit PSMD1 regulates breast cancer cell growth through p53 protein degradation. J Biochem. 2017;: pubmed publisher
    ..These findings will provide a new insight for the mechanism underlying endocrine therapy resistance and a prognostic and therapeutic molecular target for advanced breast cancer...
  35. Khongmanee A, Lirdprapamongkol K, Tit oon P, Chokchaichamnankit D, Svasti J, Srisomsap C. Proteomic analysis reveals important role of 14-3-3? in anoikis resistance of cholangiocarcinoma cells. Proteomics. 2013;13:3157-66 pubmed publisher
    ..Our findings provide the first evidence showing that 14-3-3? protein plays a crucial role in anoikis resistance of CCA cells. Therefore, 14-3-3? might be a potential target in CCA therapy. ..
  36. Mancini M, Leo E, Takemaru K, Campi V, Castagnetti F, Soverini S, et al. 14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia. PLoS ONE. 2015;10:e0131074 pubmed publisher
    ..Our results open new routes towards the research on molecular pathways promoting the proliferative advantage of leukemic hematopoiesis over the normal counterpart. ..
  37. Sijbesma E, Skora L, Leysen S, Brunsveld L, Koch U, Nussbaumer P, et al. Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry. 2017;56:3972-3982 pubmed publisher
    ..This first identification of secondary sites on 14-3-3 proteins bound by small molecule ligands might facilitate the development of new chemical tool compounds for more selective PPI modulation. ..
  38. Recio R, Elhalem E, Benito J, Fernández I, Khiar N. NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins. Carbohydr Polym. 2018;187:118-125 pubmed publisher
  39. Wakabayashi K, Umahara T, Hirokawa K, Hanyu H, Uchihara T. 14-3-3 protein sigma isoform co-localizes with phosphorylated α-synuclein in Lewy bodies and Lewy neurites in patients with Lewy body disease. Neurosci Lett. 2018;674:171-175 pubmed publisher
    ..Although the precise role of 14-3-3 sigma in the development of Lewy pathology remains elusive, its consistent association to Lewy pathology may expand our understanding of Lewy pathogenesis. ..
  40. Backs J, Song K, Bezprozvannaya S, Chang S, Olson E. CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. J Clin Invest. 2006;116:1853-64 pubmed
    ..These findings reveal a central role for HDAC4 in CaMKII signaling pathways and have implications for the control of gene expression by calcium signaling in a variety of cell types. ..
  41. Zhang Z, Qu J, Zheng C, Zhang P, Zhou W, Cui W, et al. Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis. Cell Death Dis. 2018;9:83 pubmed publisher
    ..In conclusion, activating Nrf2 antioxidant pathway suppresses EMT during PF via inhibiting the abnormal expression of Numb. These findings provide insight into PF pathogenesis and a basis for novel treatment approaches. ..
  42. Sluchanko N, Beelen S, Kulikova A, Weeks S, Antson A, Gusev N, et al. Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator. Structure. 2017;25:305-316 pubmed publisher
  43. Sun B, Li Y, Liu L, Chen Z, Ling L, Yang F, et al. SFN-SIQ, SFNSL and skin biopsy of 55 cases with small fibre involvement. Int J Neurosci. 2018;128:442-448 pubmed publisher
  44. Islam S, Mokhtari R, Akbari P, Hatina J, Yeger H, Farhat W. Simultaneous Targeting of Bladder Tumor Growth, Survival, and Epithelial-to-Mesenchymal Transition with a Novel Therapeutic Combination of Acetazolamide (AZ) and Sulforaphane (SFN). Target Oncol. 2016;11:209-27 pubmed publisher
    ..Altogether, our in vitro and pre-clinical model data support the potential use of an AZ + SFN combination for the treatment of bladder cancer. ..
  45. Liu P, Atkinson S, Akbareian S, Zhou Z, Munsterberg A, Robinson S, et al. Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1?/VEGF signalling. Sci Rep. 2017;7:12651 pubmed publisher
    ..Collectively, these findings provide new insights into the inhibitory effect of SFN on HCC tumor angiogenesis as well as tumor growth, and indicate that SFN has potential for the prevention and treatment of HCC...
  46. Hudecova S, Markova J, Simko V, Csaderova L, Stracina T, Sirova M, et al. Sulforaphane-induced apoptosis involves the type 1 IP3 receptor. Oncotarget. 2016;7:61403-61418 pubmed publisher
    ..Our results clearly show that IP3R1 is involved in SFN-induced apoptosis through the depletion of reticular calcium and modulation of transcription factors through nuclear calcium up-regulation. ..
  47. Wang Y, He L, Yuan M, Tsang W, Hao L, Wang M, et al. Epigenetic changes of TIMP-3, GSTP-1 and 14-3-3 sigma genes as indication of status of chronic inflammation and cancer. Int J Biol Markers. 2014;29:e208-14 pubmed publisher
  48. Wang X, Campos C, Peart J, Smith L, Boni J, Cannon R, et al. Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriers. J Neurosci. 2014;34:8585-93 pubmed publisher
    ..They imply that the barriers are tightened selectively (efflux transporter upregulation) by oxidative stress, providing increased neuroprotection, but also reduced penetration of many therapeutic drugs. ..
  49. Jin Y, Dai M, Lu S, Xu Y, Luo Z, Zhao Y, et al. 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J. 2006;25:1207-18 pubmed
    ..Finally, ablation of 14-3-3gamma by siRNA reduced UV-induced p53 level and G1 arrest. Thus, these results demonstrate 14-3-3gamma and Chk1 as two novel regulators of MDMX in response to UV irradiation. ..
  50. Yang H, Zhang Y, Zhao R, Wen Y, Fournier K, Wu H, et al. Negative cell cycle regulator 14-3-3sigma stabilizes p27 Kip1 by inhibiting the activity of PKB/Akt. Oncogene. 2006;25:4585-94 pubmed
    ..These data provide an insight into 14-3-3sigma activity and rational cancer gene therapy by identifying 14-3-3sigma as a positive regulator of p27 and as a potential anticancer agent. ..
  51. Kudo I, Esumi M, Kusumi Y, Furusaka T, Oshima T. Particular gene upregulation and p53 heterogeneous expression in TP53-mutated maxillary carcinoma. Oncol Lett. 2017;14:4633-4640 pubmed publisher
  52. Miao Z, Yu F, Ren Y, Yang J. d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway. Int J Mol Sci. 2017;18: pubmed publisher
    ..Taken together, our data suggests that SFN induces apoptosis in GBM cells via ROS-dependent inactivation of STAT3 phosphorylation. These findings motivate further evaluation of SFN as a cancer chemopreventive agent in GBM treatment. ..
  53. Kamal M, Nazzal S. Novel sulforaphane-enabled self-microemulsifying delivery systems (SFN-SMEDDS) of taxanes: Formulation development and in vitro cytotoxicity against breast cancer cells. Int J Pharm. 2018;536:187-198 pubmed publisher
    ..This study highlighted the unique properties of SFN and its potential use in reformulating taxanes with high drug load and significantly lower excipient content than the commercial products. ..
  54. Chen C, Jiang X, Gu S, Lai Y, Liu Y, Zhang Z. Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway. Environ Toxicol. 2017;32:2004-2020 pubmed publisher
    ..Our study suggests that activation of Nrf2 through the cGMP-PKG signaling pathway in HBE cells may be developed as a new strategy for prevention of arsenite toxicity. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 2004-2020, 2017...
  55. Wang A, Xu Y, Zhang Z, Lu B, Yin X, Yao A, et al. Sulforaphane protects MLE-12 lung epithelial cells against oxidative damage caused by ambient air particulate matter. Food Funct. 2017;8:4555-4562 pubmed publisher
    ..5-induced oxidative damage via activation of the Nrf2 pathway and inhibition of the mitochondrial apoptotic pathway; therefore, SFN may be a promising compound for preventing PM2.5-triggered pulmonary cell damage. ..
  56. Dong Y, Taylor J, Wolf M, Shaham Y. Circuit and Synaptic Plasticity Mechanisms of Drug Relapse. J Neurosci. 2017;37:10867-10876 pubmed publisher
    ..In the mini-review that introduces our SFN session, we summarize results from our laboratories on behavioral, cellular, and circuit mechanisms of drug relapse within the context of our session. ..
  57. Sharma T, Khurana R, Jain A, Katare O, Singh B. Development of a Validated Liquid Chromatographic Method for Quantification of Sorafenib Tosylate in the Presence of Stress-Induced Degradation Products and in Biological Matrix employing Analytical Quality by Design (AQbD) Approach. Biomed Chromatogr. 2017;: pubmed publisher
    ..65, 4.20 and 5.67 minutes. Absence of any significant change in the retention time of SFN and degradation products, formed under different stress conditions, ratified selectivity and specificity of the systematically developed method...
  58. Ku N, Michie S, Resurreccion E, Broome R, Omary M. Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression. Proc Natl Acad Sci U S A. 2002;99:4373-8 pubmed
    ..Keratin binding to 14-3-3 may partially modulate hepatocyte mitotic progression, in association with nuclear redistribution of 14-3-3 proteins during mitosis. ..
  59. Lodygin D, Hermeking H. The role of epigenetic inactivation of 14-3-3sigma in human cancer. Cell Res. 2005;15:237-46 pubmed
  60. Johnson B, Stehn J, Yaffe M, Blackwell T. Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J Biol Chem. 2002;277:18029-36 pubmed
    ..They also suggest that 14-3-3 binding is part of a complex network of stimuli and interactions that regulate TTP function. ..
  61. Sohn E, Song K, Lee J, Lee A. Comparison of Somatic and Sudomotor Nerve Fibers in Type 2 Diabetes Mellitus. J Clin Neurol. 2017;13:366-370 pubmed publisher
    ..Measuring the IENFD was a more sensitive method than the QSART for the early detection of DPN. The degree of involvement of the somatic small nerve fibers and sudomotor nerve fibers was independent in DPN. ..
  62. Zhu J, Balan V, Bronisz A, Balan K, Sun H, Leicht D, et al. Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding. Mol Biol Cell. 2005;16:4733-44 pubmed
  63. Yang H, Zhao R, Lee M. 14-3-3sigma, a p53 regulator, suppresses tumor growth of nasopharyngeal carcinoma. Mol Cancer Ther. 2006;5:253-60 pubmed
    ..These findings provide an insight into the roles of 14-3-3sigma in NPC and suggest that approaches that modulate 14-3-3sigma activity may be useful in the treatment of NPC. ..
  64. Greninger A, Knudsen G, Betegon M, Burlingame A, Derisi J. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. MBio. 2013;4:e00098-13 pubmed publisher
    ..This work informs our knowledge of both the physical interactions of the proteins that help maintain metazoan Golgi structure and how viruses subvert these evolutionarily conserved interactions for their own purposes. ..
  65. Rose R, Rose M, Ottmann C. Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. J Struct Biol. 2012;180:65-72 pubmed publisher
    ..We furthermore suggest a role of RSK-type kinases in the phosphorylation of one of these two binding sites and provide evidence in the form of in vitro kinase assays with p70S6 kinase and RSK1. ..
  66. Sang M, Geng C, Shan B. [Effect of 14-3-3sigma on transcriptional activity of p73 gene]. Ai Zheng. 2007;26:489-93 pubmed
    ..01). 14-3-3sigma can enhance the transcriptional activity of p73 in a dose-dependent manner. ..
  67. Martin M, Potente M, Janssens V, Vertommen D, Twizere J, Rider M, et al. Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis. Proc Natl Acad Sci U S A. 2008;105:4727-32 pubmed publisher
    ..This study unravels a dynamic interplay among 14-3-3s, protein kinases, and PP2A and provides a model for the regulation of class IIa HDACs. ..
  68. Son Y, Jang E, Kim Y, Lee J. Sulforaphane prevents dexamethasone-induced muscle atrophy via regulation of the Akt/Foxo1 axis in C2C12 myotubes. Biomed Pharmacother. 2017;95:1486-1492 pubmed publisher
    ..Furthermore, SFN enhanced protein synthesis through a Foxo-dependent pathway by activating Akt, and thus, increased myotube diameters. These results show SFN inhibits DEX-induced muscle atrophy in C2C12 myotubes via Akt/Foxo signaling. ..
  69. Baenas N, Suárez Martínez C, García Viguera C, Moreno D. Bioavailability and new biomarkers of cruciferous sprouts consumption. Food Res Int. 2017;100:497-503 pubmed publisher
    ..The results provide valuable information to better understand the bioavailability of cruciferous bioactives. ..
  70. Liu C, Chang T, Lin Y, Yu Y, Ko B, Sung L, et al. Paracrine regulation of matrix metalloproteinases contributes to cancer cell invasion by hepatocellular carcinoma-secreted 14-3-3?. Oncotarget. 2016;7:36988-36999 pubmed publisher
    ..These results suggest that HCC-secreted 14-3-3? promotes expression of MMPs in cancerous surrounding cells via an APN dependent mechanism. 14-3-3? has a paracrine effect in educating stromal cells in tumor-associated microenvironment. ..
  71. Lněničková K, Dymáková A, Szotakova B, Bousova I. Sulforaphane Alters β-Naphthoflavone-Induced Changes in Activity and Expression of Drug-Metabolizing Enzymes in Rat Hepatocytes. Molecules. 2017;22: pubmed publisher
    ..Sulforaphane is able to modulate the activity and/or expression of DMEs, thus shifting the balance of carcinogen metabolism toward deactivation, which could represent an important mechanism of its chemopreventive activity. ..
  72. Yeh C, Pang S, Jung S, Chen T, Jan Y, Chen M. Cytoplasmic overexpression with membrane accentuation of stratifin in intrahepatic mass-forming cholangiocarcinoma after hepatectomy: correlation with clinicopathologic features and patient survival. J Surg Oncol. 2010;102:608-14 pubmed publisher
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