STMN1

Summary

Gene Symbol: STMN1
Description: stathmin 1
Alias: C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN, stathmin, leukemia-associated phosphoprotein p18, metablastin, oncoprotein 18, phosphoprotein 19, phosphoprotein p19, prosolin, stathmin 1/oncoprotein 18, testicular tissue protein Li 189, transmembrane protein C1orf215
Species: human
Products:     STMN1

Top Publications

  1. Sobel A. Stathmin: a relay phosphoprotein for multiple signal transduction?. Trends Biochem Sci. 1991;16:301-5 pubmed
    b>Stathmin is a ubiquitous, phylogenetically conserved protein present in the cytoplasm of cells in a variety of unphosphorylated and phosphorylated forms...
  2. Holmfeldt P, Sellin M, Gullberg M. Upregulated Op18/stathmin activity causes chromosomal instability through a mechanism that evades the spindle assembly checkpoint. Exp Cell Res. 2010;316:2017-26 pubmed publisher
    Op18/stathmin (Op18) is a microtubule-destabilizing protein that is phosphorylation-inactivated during mitosis and its normal function is to govern tubulin subunit partitioning during interphase...
  3. Gan L, Guo K, Li Y, Kang X, Sun L, Shu H, et al. Up-regulated expression of stathmin may be associated with hepatocarcinogenesis. Oncol Rep. 2010;23:1037-43 pubmed
    b>Stathmin is a microtubule-destabilizing protein ubiquitously expressed in vertebrates and overexpressed in a variety of human malignancies...
  4. Howell B, Larsson N, Gullberg M, Cassimeris L. Dissociation of the tubulin-sequestering and microtubule catastrophe-promoting activities of oncoprotein 18/stathmin. Mol Biol Cell. 1999;10:105-18 pubmed
    b>Oncoprotein 18/stathmin (Op18) has been identified recently as a protein that destabilizes microtubules, but the mechanism of destabilization is currently controversial...
  5. Wong Q, Lung R, Law P, Lai P, Chan K, To K, et al. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. Gastroenterology. 2008;135:257-69 pubmed publisher
    ..01). Integrative analysis further implicated Stathmin 1 (STMN1) as a downstream target of miR-223...
  6. Sellin M, Holmfeldt P, Stenmark S, Gullberg M. Global regulation of the interphase microtubule system by abundantly expressed Op18/stathmin. Mol Biol Cell. 2008;19:2897-906 pubmed publisher
    Op18/stathmin (Op18), a conserved microtubule-depolymerizing and tubulin heterodimer-binding protein, is a major interphase regulator of tubulin monomer-polymer partitioning in diverse cell types in which Op18 is abundant...
  7. Golouh R, Cufer T, Sadikov A, Nussdorfer P, Usher P, Brunner N, et al. The prognostic value of Stathmin-1, S100A2, and SYK proteins in ER-positive primary breast cancer patients treated with adjuvant tamoxifen monotherapy: an immunohistochemical study. Breast Cancer Res Treat. 2008;110:317-26 pubmed
    We recently found that DNA methylation of S100A2, spleen tyrosine kinase (SYK), and Stathmin-1 (STMN1) correlates with response to tamoxifen therapy in metastatic breast cancer...
  8. Ng D, Lin B, Lim C, Huang G, Zhang T, Poli V, et al. Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. J Cell Biol. 2006;172:245-57 pubmed
    ..In this study, we reveal an interaction between Stat3 and the microtubule (MT)-destabilizing protein stathmin. Stathmin did not overtly affect ligand-stimulated Stat3 activation...
  9. Kouzu Y, Uzawa K, Koike H, Saito K, Nakashima D, Higo M, et al. Overexpression of stathmin in oral squamous-cell carcinoma: correlation with tumour progression and poor prognosis. Br J Cancer. 2006;94:717-23 pubmed
    b>Stathmin is an intracellular phosphoprotein that is overexpressed in a number of human malignancies...

More Information

Publications84

  1. Ghosh R, Gu G, Tillman E, Yuan J, Wang Y, Fazli L, et al. Increased expression and differential phosphorylation of stathmin may promote prostate cancer progression. Prostate. 2007;67:1038-52 pubmed
    ..b>Stathmin expression and phosphorylation patterns were analyzed in mouse and human PCa cell lines as well as in human PCa ..
  2. Zhang H, Wang Y, Gao P, Lin F, Liu L, Yu B, et al. Silencing stathmin gene expression by survivin promoter-driven siRNA vector to reverse malignant phenotype of tumor cells. Cancer Biol Ther. 2006;5:1457-61 pubmed
    b>Stathmin gene overexpression has been shown to play an important role in maintenance of malignant phenotype in tumor cells, and the blocking efficacy and tumor specificity of this target has been concerned in clinical trails...
  3. Li N, Jiang P, Du W, Wu Z, Li C, Qiao M, et al. Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules. Proc Natl Acad Sci U S A. 2011;108:12851-6 pubmed publisher
    ..Here we report that Siva1 interacts with stathmin, a microtubule destabilizer...
  4. Kang W, Tong J, Chan A, Lung R, Chau S, Wong Q, et al. Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer. PLoS ONE. 2012;7:e33919 pubmed publisher
    Stathmin1 (STMN1) is a candidate oncoprotein and prognosis marker in several kinds of cancers. This study was aimed to analyze its expression and biological functions in gastric cancer...
  5. Jeon T, Han M, Lee Y, Lee Y, Kim G, Song G, et al. Overexpression of stathmin1 in the diffuse type of gastric cancer and its roles in proliferation and migration of gastric cancer cells. Br J Cancer. 2010;102:710-8 pubmed publisher
    ..These results suggest that stathmin1 can be a good prognostic factor for recurrence-free survival rate and is a therapeutic target in diffuse-type gastric cancer. ..
  6. Brocke B, Lesch K, Armbruster D, Moser D, Müller A, Strobel A, et al. Stathmin, a gene regulating neural plasticity, affects fear and anxiety processing in humans. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:243-51 pubmed publisher
    ..Recently it has been demonstrated that stathmin, a regulator of microtubule formation which affects long-term potentiation (LTP), controls learned and innate ..
  7. Byrne F, Yang L, Phillips P, Hansford L, Fletcher J, Ormandy C, et al. RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model. Oncogene. 2014;33:882-90 pubmed publisher
    Metastatic neuroblastoma is an aggressive childhood cancer of neural crest origin. Stathmin, a microtubule destabilizing protein, is highly expressed in neuroblastoma although its functional role in this malignancy has not been addressed...
  8. Sobel A, Boutterin M, Beretta L, Chneiweiss H, Doye V, Peyro Saint Paul H. Intracellular substrates for extracellular signaling. Characterization of a ubiquitous, neuron-enriched phosphoprotein (stathmin). J Biol Chem. 1989;264:3765-72 pubmed
    ..We propose to name this protein stathmin, from the greek "stathmos" (relay).
  9. Chen G, Wang H, Gharib T, Huang C, Thomas D, Shedden K, et al. Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas. Mol Cell Proteomics. 2003;2:107-16 pubmed
    We examined the expression of oncoprotein 18 (Op18) in 93 lung adenocarcinomas and 10 uninvolved lung samples using quantitative two-dimensional PAGE analysis with confirmation by mass spectrometry and two-dimensional Western blot ..
  10. Marklund U, Brattsand G, Shingler V, Gullberg M. Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase. J Biol Chem. 1993;268:15039-47 pubmed
    b>Oncoprotein 18 (Op18) is an 18-19-kDa cytoplasmic phosphoprotein, of unknown function, that is frequently up-regulated in transformed cells...
  11. Sonego M, Schiappacassi M, Lovisa S, Dall Acqua A, Bagnoli M, Lovat F, et al. Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer. EMBO Mol Med. 2013;5:707-22 pubmed publisher
    b>Stathmin is a p53-target gene, frequently overexpressed in late stages of human cancer progression. Type II High Grade Epithelial Ovarian Carcinomas (HG-EOC) represents the only clear exception to this observation...
  12. Gavet O, Ozon S, Manceau V, Lawler S, Curmi P, Sobel A. The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. J Cell Sci. 1998;111 ( Pt 22):3333-46 pubmed
    b>Stathmin is a small regulatory phosphoprotein integrating diverse intracellular signaling pathways...
  13. Wik E, Birkeland E, Trovik J, Werner H, Hoivik E, Mjos S, et al. High phospho-Stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition. Clin Cancer Res. 2013;19:2331-41 pubmed publisher
    High Stathmin expression has recently been associated with clinical progress in endometrial cancers. Stathmin protein activity is modulated by phosphorylation, and the Serine38 site is one of four Stathmin phospho-sites...
  14. Trovik J, Wik E, Stefansson I, Marcickiewicz J, Tingulstad S, Staff A, et al. Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancer. Clin Cancer Res. 2011;17:3368-77 pubmed publisher
    Overexpression of the oncogen Stathmin has been linked to aggressive endometrial carcinoma and a potential for PI3Kinase inhibitors in this disease...
  15. Zheng P, Liu Y, Chen L, Liu X, Xiao Z, Zhao L, et al. Stathmin, a new target of PRL-3 identified by proteomic methods, plays a key role in progression and metastasis of colorectal cancer. J Proteome Res. 2010;9:4897-905 pubmed publisher
    ..We identified 39 PRL-3 associated proteins based on proteomic strategy. Stathmin, a key oncoprotein, was proved to be a new PRL-3 associated protein...
  16. Wang F, Wang L, He W, Zhu L, Zhao P, Fan Q. [Expression of stathmin in esophageal squamous cell carcinoma and its biological significance]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:1552-7 pubmed
    To explore the expression of stathmin gene in esophageal squamous cell carcinoma (ESCC) and its correlation to oncogenesis of ESCC...
  17. Kuo M, Wang H, Kuo Q, Shun C, Hsu H, Yang S, et al. High expression of stathmin protein predicts a fulminant course in medulloblastoma. J Neurosurg Pediatr. 2009;4:74-80 pubmed publisher
    b>Stathmin, an important cytosolic phosphoprotein, is involved in cell proliferation and motility. This study was performed to elucidate the role of stathmin in the progression of medulloblastoma...
  18. Steinmetz M. Structure and thermodynamics of the tubulin-stathmin interaction. J Struct Biol. 2007;158:137-47 pubmed
    b>Oncoprotein 18/stathmin (stathmin) is a phosphorylation-controlled key regulator of microtubule dynamics...
  19. Chen J, Abi Daoud M, Wang A, Yang X, Zhang X, Feilotter H, et al. Stathmin 1 is a potential novel oncogene in melanoma. Oncogene. 2013;32:1330-7 pubmed publisher
    ..We suggested that stathmin 1 (STMN1) might be a target of miR-193b...
  20. Wang R, Wang H, Hao C, Cui Y, Han X, Hu Y, et al. MiR-101 is involved in human breast carcinogenesis by targeting Stathmin1. PLoS ONE. 2012;7:e46173 pubmed publisher
    ..Further investigation revealed a significant inverse correlation between the expression of miR-101 and Stathmin1 (Stmn1), and miR-101 could bind to the 3'-untranslated region (UTR) of Stmn1 to inhibit Stmn1 translation...
  21. Misek D, Chang C, Kuick R, Hinderer R, Giordano T, Beer D, et al. Transforming properties of a Q18-->E mutation of the microtubule regulator Op18. Cancer Cell. 2002;2:217-28 pubmed
    We have identified a somatic mutation in Op18 in a human esophageal adenocarcinoma...
  22. Belletti B, Nicoloso M, Schiappacassi M, Berton S, Lovat F, Wolf K, et al. Stathmin activity influences sarcoma cell shape, motility, and metastatic potential. Mol Biol Cell. 2008;19:2003-13 pubmed publisher
    ..Among the destabilizing proteins, stathmin is overexpressed in different human malignancies and has been recently linked to the regulation of cell motility...
  23. Baldassarre G, Belletti B, Nicoloso M, Schiappacassi M, Vecchione A, Spessotto P, et al. p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell. 2005;7:51-63 pubmed
    ..This p27(kip1) activity is due to its ability to bind and impair the function of the MT-destabilizing protein stathmin. Accordingly, upregulation of p27(kip1) or downregulation of stathmin expression results in the inhibition of ..
  24. Singer S, Ehemann V, Brauckhoff A, Keith M, Vreden S, Schirmacher P, et al. Protumorigenic overexpression of stathmin/Op18 by gain-of-function mutation in p53 in human hepatocarcinogenesis. Hepatology. 2007;46:759-68 pubmed
    The microtubule (MT)-destabilizing protein stathmin/Op18 has previously been described to be negatively regulated by p53 and to be highly expressed in several tumor entities...
  25. Zhang Y, Xiong J, Wang J, Shi X, Bao G, Zhang Y, et al. Regulation of melanocyte apoptosis by Stathmin 1 expression. BMB Rep. 2008;41:765-70 pubmed
    ..The role of Stathmin 1 as an important regulator of microtubule dynamics is well documented...
  26. Tan H, Wu W, Ng Y, Zhang X, Yan B, Ong C, et al. Proteomic analysis of colorectal cancer metastasis: stathmin-1 revealed as a player in cancer cell migration and prognostic marker. J Proteome Res. 2012;11:1433-45 pubmed publisher
    ..Among these proteins, stathmin-1 (STMN1) was found to be highly up-regulated in E1 as compared to HCT-116 and was thus selected for further ..
  27. Ehlis A, Bauernschmitt K, Dresler T, Hahn T, Herrmann M, Röser C, et al. Influence of a genetic variant of the neuronal growth associated protein Stathmin 1 on cognitive and affective control processes: an event-related potential study. Am J Med Genet B Neuropsychiatr Genet. 2011;156B:291-302 pubmed publisher
    b>Stathmin 1 (STMN1) is a neuronal growth associated protein (NGAP) that is involved in microtubule dynamics and plays an important role in neurite outgrowth and synaptic plasticity...
  28. Xi W, Rui W, Fang L, Ke D, Ping G, Hui Zhong Z. Expression of stathmin/op18 as a significant prognostic factor for cervical carcinoma patients. J Cancer Res Clin Oncol. 2009;135:837-46 pubmed publisher
    b>Stathmin (Oncoprotein18), a ubiquitous and highly conserved 19-kDa cytosolic phosphoprotein, has been reported to play a critical role in mitosis and possibly other cellular processes, which is associated with tumor carcinogenesis and ..
  29. Alli E, Yang J, Hait W. Silencing of stathmin induces tumor-suppressor function in breast cancer cell lines harboring mutant p53. Oncogene. 2007;26:1003-12 pubmed
    ..We found that inhibition of stathmin, a microtubule regulator that can be transcriptionally repressed by wild-type p53, restored certain wild-type ..
  30. Doye V, le Gouvello S, Dobransky T, Chneiweiss H, Beretta L, Sobel A. Expression of transfected stathmin cDNA reveals novel phosphorylated forms associated with developmental and functional cell regulation. Biochem J. 1992;287 ( Pt 2):549-54 pubmed
    b>Stathmin is a ubiquitous, highly conserved phosphoprotein, which most likely acts as an intracellular relay integrating various transduction pathways triggered by extracellular signals...
  31. Larsson N, Marklund U, Gradin H, Brattsand G, Gullberg M. Control of microtubule dynamics by oncoprotein 18: dissection of the regulatory role of multisite phosphorylation during mitosis. Mol Cell Biol. 1997;17:5530-9 pubmed
    b>Oncoprotein 18 (Op18; also termed p19, 19K, metablastin, stathmin, and prosolin) is a conserved protein that regulates microtubule (MT) dynamics...
  32. Parra Orobio B, Donoso Bravo A, Ruiz Sánchez J, Valencia Molina K, Torres Lozada P. Effect of inoculum on the anaerobic digestion of food waste accounting for the concentration of trace elements. Waste Manag. 2018;71:342-349 pubmed publisher
    ..19 d-1), and the lag-phase (>7 days). It was also found that high concentrations of trace elements such as Ni (35...
  33. Shau D, Patton R, Patel S, Ward L, Guild G. Synthetic mesh vs. allograft extensor mechanism reconstruction in total knee arthroplasty - A systematic review of the literature and meta-analysis. Knee. 2018;25:2-7 pubmed publisher
    ..74% mesh), average time to diagnosis/treatment, Knee Society Scores (KSS), knee range of motion/extensor lag, and complication rates yielded no statistical difference...
  34. Chen Z, Yoo S, Takahashi J. Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems. Annu Rev Pharmacol Toxicol. 2018;58:231-252 pubmed publisher
    ..We highlight the therapeutic potential of small molecules in clock-related pathologies, including jet lag and shiftwork; various chronic diseases, particularly metabolic disease; and aging...
  35. Collier Z, Roughton M, Gottlieb L. Negligent and Inflicted Burns in Children. Clin Plast Surg. 2017;44:467-477 pubmed publisher
    ..Children are vulnerable and error or lag in diagnosis may lead to further injury or death. In contrast, misdiagnosis of abuse is also unacceptable...
  36. Wang H, Jo Y, Sun T, Namgoong S, Cui X, Oh J, et al. Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis. Biochim Biophys Acta. 2016;1863:2993-3000 pubmed publisher
    ..Inhibition of CDK7 using THZ1 accelerated the first meiosis, leading to chromosome misalignment, lag of chromosomes during chromosome segregation, and a high incidence of aneuploidy...
  37. Kuhn S, Greenfield J, Arand C, Jarmolaew A, Appelmann P, Mehler D, et al. Treatment of distal intraarticular tibial fractures: A biomechanical evaluation of intramedullary nailing vs. angle-stable plate osteosynthesis. Injury. 2015;46 Suppl 4:S99-S103 pubmed publisher
    ..After primary lag screw fixation, 4-hole Medial Distal Tibial Plate (MDTP) with triple proximal and quadruple distal screws or ..
  38. Wu X, Hou J, Chen X, Chen X, Zhao W. Identification and functional analysis of the L-ascorbate-specific enzyme II complex of the phosphotransferase system in Streptococcus mutans. BMC Microbiol. 2016;16:51 pubmed publisher
    ..ptxA (-), ptxB (-), as well as ptxA (-) , ptxB (-) double-deletion mutants all had more extended lag phase and lower growth yield than wild-type strain UA159 when grown in the medium using L-ascorbate as the sole ..
  39. Xu D, Sun P, Wang J, Yang H, Zhao W. A combined partially threaded cancellous lag screw for achieving maximum compressive force without compromising pullout strength. Eur Rev Med Pharmacol Sci. 2016;20:208-13 pubmed
    The partially threaded cancellous lag screw (PTLS) could not provide maximum compressive force (C(MAX)) for compression due to compromised pullout strength (POS)...
  40. Maroni A, Del Curto M, Salmaso S, Zema L, Melocchi A, Caliceti P, et al. In vitro and in vivo evaluation of an oral multiple-unit formulation for colonic delivery of insulin. Eur J Pharm Biopharm. 2016;108:76-82 pubmed publisher
    ..respectively, at delaying the onset of release through swelling/erosion processes, extending the duration of the lag phase by slowing down water penetration into the underlying functional layer, and overcoming variable gastric ..
  41. Hernandez Castillo C, Diedrichsen J, Aguilar Castañeda E, Iglesias M. Decoupling between the hand territory and the default mode network after bilateral arm transplantation: four-year follow-up case study. Brain Imaging Behav. 2018;12:296-302 pubmed publisher
    ..between the cortical territory of the new hand and two intrinsic network of interest: the sensorimotor network (SMN) and the default mode network (DMN) of one patient whom received bilateral forearm transplants...
  42. Bello G, Arora M, Austin C, Horton M, Wright R, Gennings C. Extending the Distributed Lag Model framework to handle chemical mixtures. Environ Res. 2017;156:253-264 pubmed publisher
    Distributed Lag Models (DLMs) are used in environmental health studies to analyze the time-delayed effect of an exposure on an outcome of interest...
  43. Tsai Y, Yang Y, Ho Y, Tsai M, Mi F. Drug release and antioxidant/antibacterial activities of silymarin-zein nanoparticle/bacterial cellulose nanofiber composite films. Carbohydr Polym. 2018;180:286-296 pubmed publisher
    ..In this study, flavonoid silymarin (SMN) and zein were assembled into spherical SMN-Zein nanoparticles that could be effectively adsorbed onto BC ..
  44. Tam W, Lo K, Khalechelvam P, Seah J, Goh S. Is the information of systematic reviews published in nursing journals up-to-date? a cross-sectional study. BMC Med Res Methodol. 2017;17:151 pubmed publisher
    ..5 (53.5-427) and 153 (92-212), respectively. No significant association were revealed between the time lag and those potential factors...
  45. Sexauer A, Tasian S. Targeting FLT3 Signaling in Childhood Acute Myeloid Leukemia. Front Pediatr. 2017;5:248 pubmed publisher
    ..Clinical outcomes for children with AML treated with maximally intensive multi-agent chemotherapy lag far behind those of children with the more common acute lymphoblastic leukemia, demonstrating continued need for ..
  46. Mukai S, Ikeda M, Takezawa Y, Sugano M, Honda T, Okumura N. Differences in the function and secretion of congenital aberrant fibrinogenemia between heterozygous γD320G (Okayama II) and γΔN319-ΔD320 (Otsu I). Thromb Res. 2015;136:1318-24 pubmed publisher
    ..The lag period for the fibrin polymerization of Okayama II was slightly slower than that of the normal control, whereas ..
  47. Luo K, Li W, Zhang R, Li R, Xu Q, Cao Y. Ambient Fine Particulate Matter Exposure and Risk of Cardiovascular Mortality: Adjustment of the Meteorological Factors. Int J Environ Res Public Health. 2016;13: pubmed
    Few studies have explicitly explored the impacts of the extensive adjustment (with a lag period of more than one week) of temperature and humidity on the association between ambient fine particulate matter (PM2...
  48. Kraper C, Kenworthy L, Popal H, Martin A, Wallace G. The Gap Between Adaptive Behavior and Intelligence in Autism Persists into Young Adulthood and is Linked to Psychiatric Co-morbidities. J Autism Dev Disord. 2017;47:3007-3017 pubmed publisher
    ..Adaptive functioning was found to substantially lag behind IQ, and socialization was a particular weakness...
  49. Mavridou E, Meletiadis J, Jancura P, Abbas S, Arendrup M, Melchers W, et al. Composite survival index to compare virulence changes in azole-resistant Aspergillus fumigatus clinical isolates. PLoS ONE. 2013;8:e72280 pubmed publisher
    ..Our model elucidates how three critical parameters (the lag phase (τ), decay constant (λ), and growth rate (ν)) interact with each other resulting in a CSI that correlated ..
  50. Druelle F, Aerts P, Berillon G. The origin of bipedality as the result of a developmental by-product: The case study of the olive baboon (Papio anubis). J Hum Evol. 2017;113:155-161 pubmed publisher
    ..e., duty factor, dimensionless frequency, and hind lag) do not change during development, the baboon is able to significantly improve the coordination pattern between ..
  51. Edwards C, Oswald T. Interactive effects between total SO2 , ethanol and storage temperature against Brettanomyces bruxellensis. Lett Appl Microbiol. 2018;66:71-76 pubmed publisher
    ..ethanol and stored at 15°C, addition of 100 mg l-1 total SO2 resulted in much longer lag phases (>40 days) compared with wines without sulphites...
  52. Zaworski P, von Herrmann K, Taylor S, Sunshine S, McCarthy K, Risher N, et al. SMN Protein Can Be Reliably Measured in Whole Blood with an Electrochemiluminescence (ECL) Immunoassay: Implications for Clinical Trials. PLoS ONE. 2016;11:e0150640 pubmed publisher
    ..atrophy (SMA) is caused by defects in the survival motor neuron 1 (SMN1) gene that encodes survival motor neuron (SMN) protein...
  53. Lunn R, Blask D, Coogan A, Figueiro M, Gorman M, Hall J, et al. Health consequences of electric lighting practices in the modern world: A report on the National Toxicology Program's workshop on shift work at night, artificial light at night, and circadian disruption. Sci Total Environ. 2017;607-608:1073-1084 pubmed publisher
    ..disruption, such as night-shift work and atypical and inconsistent sleep-wake patterns that can lead to social jet lag. Future studies should more comprehensively characterize and measure the relevant light-related exposures and link ..
  54. Fischer Baum S, Bruggemann D, Gallego I, Li D, Tamez E. Decoding levels of representation in reading: A representational similarity approach. Cortex. 2017;90:88-102 pubmed publisher
    ..Taken together, these results suggest an interactive activation theory of visual word processing in which both the lvOT and lAG are neural loci of an orthographic level of representations.
  55. Tushingham S, Fulkerson T, Hill K. The peer review gap: A longitudinal case study of gendered publishing and occupational patterns in a female-rich discipline, Western North America (1974-2016). PLoS ONE. 2017;12:e0188403 pubmed publisher
    ..backgrounds, but, because of the current structure of our discipline-including the fact that women and minorities lag in positions where costly peer-reviewed publication is a rewarded and supported activity-overwhelmingly affect ..
  56. Bae J, Hideshima T, Zhang G, Zhou J, Keskin D, Munshi N, et al. Identification and characterization of HLA-A24 specific XBP1, CD138 (Syndecan-1), and CS1 (SLAMF7) peptides inducing antigens-specific memory cytotoxic T lymphocytes targeting multiple myeloma. Leukemia. 2017;: pubmed publisher
    ..Leukemia accepted article preview online, 01 November 2017. doi:10.1038/leu.2017.316...
  57. Bowerman M, Swoboda K, Michalski J, Wang G, Reeks C, Beauvais A, et al. Glucose metabolism and pancreatic defects in spinal muscular atrophy. Ann Neurol. 2012;72:256-68 pubmed publisher
    ..Glucose metabolism and pancreas development were investigated in the Smn(2B/-) intermediate SMA mouse model and type I SMA patients...
  58. Freeman W, Rogers L. Fine temporal resolution of analytic phase reveals episodic synchronization by state transitions in gamma EEGs. J Neurophysiol. 2002;87:937-45 pubmed
    ..Phase locking within each PM pattern is not at zero phase lag but over a fixed distribution of phase values that is consistent with the radially symmetric phase gradients ..
  59. Tapia O, Narcís J, Riancho J, Tarabal O, Piedrafita L, Caldero J, et al. Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus. Neurobiol Dis. 2017;108:83-99 pubmed publisher
    ..by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs)...
  60. Schroeder S. American health improvement depends upon addressing class disparities. Prev Med. 2016;92:6-15 pubmed publisher
    ..But it is clear that without focusing on the less fortunate members of our society, especially those in the Southeast, our performance will continue to lag, and possibly deteriorate further.
  61. Huang F, Chen R, Shen Y, Kan H, Kuang X. The Impact of the 2013 Eastern China Smog on Outpatient Visits for Coronary Heart Disease in Shanghai, China. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..For example, the RR was 1.18 (95% CI: 1.04, 1.32) on lag 0 day. There were similar effects on males and females...
  62. Calabrese S, Underhill K, Mayer K. HIV Preexposure Prophylaxis and Condomless Sex: Disentangling Personal Values From Public Health Priorities. Am J Public Health. 2017;107:1572-1576 pubmed publisher
    ..but forgoing condoms while taking PrEP has proven controversial; this controversy may be contributing to the lag in PrEP uptake...
  63. Wendelken C, Ferrer E, Ghetti S, Bailey S, Cutting L, Bunge S. Frontoparietal Structural Connectivity in Childhood Predicts Development of Functional Connectivity and Reasoning Ability: A Large-Scale Longitudinal Investigation. J Neurosci. 2017;37:8549-8558 pubmed publisher
    ..2016). Here, we sought to investigate the concurrent and dynamic, lead-lag relationships among frontoparietal SC, FC, and reasoning ability in humans...
  64. Van Stan J, Park S, Jarvis M, Mehta D, Hillman R, Sternad D. Measuring vocal motor skill with a virtual voice-controlled slingshot. J Acoust Soc Am. 2017;142:1199 pubmed publisher
    ..b>Lag-1 autocorrelation (AC1) and detrended-fluctuation-analysis scaling index (SCI) analyzed temporal aspects of ..
  65. Sulaiman C, Abdul Rahim A. The relationship between CO2 emission, energy consumption and economic growth in Malaysia: a three-way linkage approach. Environ Sci Pollut Res Int. 2017;24:25204-25220 pubmed publisher
    ..An autoregressive distributed lag approach was employed to achieve the objective of the study and gauged by dynamic ordinary least squares...
  66. Fontes L, Conceição O, Machado S. Childhood and adolescent sexual abuse, victim profile and its impacts on mental health. Cien Saude Colet. 2017;22:2919-2928 pubmed publisher
    ..profile and that they are more likely to use alcohol and drugs, be victim of bullying, to be in age-grade lag, to be employed and not to intend to continue studying...
  67. Abramowitz S, McKune S, Fallah M, Monger J, Tehoungue K, Omidian P. The Opposite of Denial: Social Learning at the Onset of the Ebola Emergency in Liberia. J Health Commun. 2017;22:59-65 pubmed publisher
    ..Changes in practices tended to lag behind the acquisition of learning...
  68. Morandi B, Kail J, Toedter A, Wolter C, Piégay H. Diverse Approaches to Implement and Monitor River Restoration: A Comparative Perspective in France and Germany. Environ Manage. 2017;60:931-946 pubmed publisher
    ..The results underline four major trends: (1) a lag of almost 15 years in river restoration implementation between France and Germany, with a consequently higher share ..
  69. Alexander J, Chalmandrier L, Lenoir J, Burgess T, Essl F, Haider S, et al. Lags in the response of mountain plant communities to climate change. Glob Chang Biol. 2017;: pubmed publisher
    ..g. species distribution models) rarely consider that plant community changes could substantially lag behind climatic changes, hindering our ability to make temporally realistic projections for the coming century...
  70. Denti P, Garcia Prats A, Draper H, Wiesner L, Winckler J, Thee S, et al. Levofloxacin Population Pharmacokinetics in South African Children Treated for Multidrug-Resistant Tuberculosis. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..Levofloxacin followed 2-compartment kinetics with first-order elimination and absorption with a lag time...
  71. Li Q, Xu M, Wang G, Chen R, Qiao W, Wang X. Biochar assisted thermophilic co-digestion of food waste and waste activated sludge under high feedstock to seed sludge ratio in batch experiment. Bioresour Technol. 2018;249:1009-1016 pubmed publisher
    ..25, 0.75, 1.5, 2.25, and 3. The results showed that the presence of BC dramatically shortened the lag time of methane production and increased the methane production rate with increased organic loading...
  72. Saito A, Tomita A, Ando R, Watanabe K, Akima H. Similarity of muscle synergies extracted from the lower limb including the deep muscles between level and uphill treadmill walking. Gait Posture. 2018;59:134-139 pubmed publisher
    ..similarity of the synergy activation coefficients was high for the four synergies, and a significant lag time for synergy 2, which consisted mainly of the activity of medial gastrocnemius, was found at 60 and 80m/min...
  73. Savran D, Pérez Rodriguez F, Halkman A. Modeling the survival of Salmonella Enteritidis and Salmonella Typhimurium during the fermentation of yogurt. Food Sci Technol Int. 2017;:1082013217734089 pubmed publisher
    ..However, the µmax values significantly differed between the two serovars ( P?<?0.05). The ? values (lag time) did not have a clear trend in either of the pathogens...
  74. Liu Y, Zhou Y, Ma J, Bao W, Li J, Zhou T, et al. Inverse Association between Ambient Sulfur Dioxide Exposure and Semen Quality in Wuhan, China. Environ Sci Technol. 2017;51:12806-12814 pubmed publisher
    ..to estimate individual exposures to SO2, NO2, CO, and O3 during the entire period (lag 0-90 days) and key periods (lag 0-9, 10-14, 70-90 days) of sperm development...
  75. Moretto M, Hwang S, Khan I. Downregulated IL-21 Response and T Follicular Helper Cell Exhaustion Correlate with Compromised CD8 T Cell Immunity during Chronic Toxoplasmosis. Front Immunol. 2017;8:1436 pubmed publisher
    ..in CD8 T cells from KO mice was associated with a significant increase in other inhibitory receptors like Tim-3, LAG-3, and 2B4...