STK4

Summary

Gene Symbol: STK4
Description: serine/threonine kinase 4
Alias: KRS2, MST1, YSK3, serine/threonine-protein kinase 4, STE20-like kinase MST1, kinase responsive to stress 2, mammalian STE20-like protein kinase 1, mammalian sterile 20-like 1, serine/threonine-protein kinase Krs-2
Species: human
Products:     STK4

Top Publications

  1. Graves J, Gotoh Y, Draves K, Ambrose D, Han D, Wright M, et al. Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J. 1998;17:2224-34 pubmed
    b>Mst1 is a ubiquitously expressed serine-threonine kinase, homologous to the budding yeast Ste20, whose physiological regulation and cellular function are unknown...
  2. Graves J, Draves K, Gotoh Y, Krebs E, Clark E. Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis. J Biol Chem. 2001;276:14909-15 pubmed
    The serine/threonine kinase Mst1, a mammalian homolog of the budding yeast Ste20 kinase, is cleaved by caspase-mediated proteolysis in response to apoptotic stimuli such as ligation of CD95/Fas or treatment with staurosporine...
  3. Cheung W, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen C, et al. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell. 2003;113:507-17 pubmed
    ..We identify a 34 kDa apoptosis-induced H2B kinase as caspase-cleaved Mst1 (mammalian sterile twenty) kinase...
  4. Cinar B, Fang P, Lutchman M, Di Vizio D, Adam R, Pavlova N, et al. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J. 2007;26:4523-34 pubmed
    Akt kinases mediate cell growth and survival. Here, we report that a pro-apoptotic kinase, Mst1/STK4, is a physiological Akt1 interaction partner...
  5. Yun H, Yoon J, Lee J, Noh K, Yoon K, Oh S, et al. Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling. EMBO J. 2011;30:2465-76 pubmed publisher
    ..Here, we show that Daxx and mammalian Ste20-like kinase-1 (MST1) mediate apoptosis elicited by interferon-? (IFN-?) in microglia...
  6. Creasy C, Ambrose D, Chernoff J. The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain. J Biol Chem. 1996;271:21049-53 pubmed
    The human serine/threonine protein kinases, Mst1 and Mst2, share considerable homology to Ste20 and p21-activated kinase (Pak) throughout their catalytic domains...
  7. Lee K, Ohyama T, Yajima N, Tsubuki S, Yonehara S. MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. J Biol Chem. 2001;276:19276-85 pubmed
    ..In this study, we show that MST1 and MST2 are direct substrates of caspase-3 both in vivo and in vitro...
  8. Lin Y, Khokhlatchev A, Figeys D, Avruch J. Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. J Biol Chem. 2002;277:47991-8001 pubmed
    The protein kinase MST1 is proapoptotic when overexpressed in an active form, however, its physiologic regulation and cellular targets are unknown...
  9. Chan E, Nousiainen M, Chalamalasetty R, Schäfer A, Nigg E, Sillje H. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene. 2005;24:2076-86 pubmed
    ..Although the function of this pathway remains poorly understood in mammals, it is intriguing that, in Drosophila, it has been linked to development and tissue homeostasis. ..

More Information

Publications119 found, 100 shown here

  1. Lehtinen M, Yuan Z, Boag P, Yang Y, Villen J, Becker E, et al. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell. 2006;125:987-1001 pubmed
    ..Here, we demonstrate that the protein kinase MST1 mediates oxidative-stress-induced cell death in primary mammalian neurons by directly activating the FOXO ..
  2. Liu M, Liu S, Tan W, Tang F, Long J, Li Z, et al. Gaseous signalling molecule SO2 via Hippo?MST pathway to improve myocardial fibrosis of diabetic rats. Mol Med Rep. 2017;16:8953-8963 pubmed publisher
    ..The expression of ERS and Hippo?MST pathway?associated proteins, including CHOP, GRP94, MST1 and MST2, were significantly upregulated. By contrast, these above?mentioned changes were reversed by SO2 treatment...
  3. Law J, Salla M, Zare A, Wong Y, Luong L, Volodko N, et al. Modulator of apoptosis 1 (MOAP-1) is a tumor suppressor protein linked to the RASSF1A protein. J Biol Chem. 2015;290:24100-18 pubmed publisher
    ..and up-regulation of genes involved in cancer regulatory pathways that include apoptosis (p53, Fas, and MST1), DNA damage control (poly(ADP)-ribose polymerase and ataxia telangiectasia mutated), those within the cell ..
  4. Yang C, Lu W, Lin T, You P, Ye M, Huang Y, et al. Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress. BMC Gastroenterol. 2013;13:67 pubmed publisher
    ..induced in response to chemical (DEN treatment) and genetic-induced hepatocarcinogenesis (disruptions in LKB1, p53, MST1/2, SAV1 and PTEN)...
  5. Li Y, Du J, Zhu E, Zhang J, Han J, Zhao W, et al. Liraglutide suppresses proliferation and induces adipogenic differentiation of 3T3-L1 cells via the Hippo-YAP signaling pathway. Mol Med Rep. 2018;17:4499-4507 pubmed publisher
    ..Finally, short interfering RNAs of mammalian ste20 kinase 1/2 (MST1/2), a key protein kinase in the Hippo?YAP pathway, were used to determine whether liraglutide regulated adipogenic ..
  6. Gonzalez E, Pitre F, Page A, Marleau J, Guidi Nissim W, St Arnaud M, et al. Trees, fungi and bacteria: tripartite metatranscriptomics of a root microbiome responding to soil contamination. Microbiome. 2018;6:53 pubmed publisher
    ..in abundance (the majority uniquely expressed in contaminated soil) including major monosaccharide transporter MST1, primary cell wall and lamella CAZy enzymes, and an ectomycorrhiza-upregulated exo-β-1,3-glucanase (GH5)...
  7. Mazelin L, Panthu B, Nicot A, Belotti E, Tintignac L, Teixeira G, et al. mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis. J Mol Cell Cardiol. 2016;97:213-25 pubmed publisher
    ..Cardiomyocyte death did not result from activation of the MST1/Hippo pro-apoptotic pathway as reported in adult rictor/mTORC2 KO hearts...
  8. Wang W, Chen S, He J, Li J, Zang X. The tumor suppressive role of RASSF1A in osteosarcoma through the Wnt signaling pathway. Tumour Biol. 2016;37:8869-77 pubmed publisher
    ..synthase kinase-3-β (GSK3-β), and increased phosphorylation of mammalian sterile 20-like kinase 1 (MST1)...
  9. Asaoka Y, Hata S, Namae M, Furutani Seiki M, Nishina H. The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish. PLoS ONE. 2014;9:e97365 pubmed publisher
    ..When Hippo signaling is activated, the core Mst1/2 kinases activate the Lats1/2 kinases, which in turn phosphorylate and inhibit the transcriptional cofactor Yap...
  10. Wang P, Mao B, Luo W, Wei B, Jiang W, Liu D, et al. The alteration of Hippo/YAP signaling in the development of hypertrophic cardiomyopathy. Basic Res Cardiol. 2014;109:435 pubmed publisher
    ..Interestingly, both mRNA and protein levels of MST1, the kinase upstream of YAP, were dramatically decreased...
  11. Matsuda T, Zhai P, Sciarretta S, Zhang Y, Jeong J, Ikeda S, et al. NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart. Circ Res. 2016;119:596-606 pubmed publisher
    ..Increased NF2 expression promoted the activation of Mst1 (mammalian sterile 20-like kinase 1) and the inhibition of Yap (Yes-associated protein), whereas knockdown of NF2 ..
  12. Liu X, Liu K, Li C, Cai J, Huang L, Chen H, et al. Heat-shock protein B1 upholds the cytoplasm reduced state to inhibit activation of the Hippo pathway in H9c2 cells. J Cell Physiol. 2019;234:5117-5133 pubmed publisher
    ..formation between HSPB1 and oxidized Prx1, leading to dephosphorylation of STE-mammalian STE20-like kinase 1 (MST1) in H9c2 cells exposed to H2 O 2 , whereas downregulation of HSPB1 induced the opposite ..
  13. Yuan L, Mao Y, Luo W, Wu W, Xu H, Wang X, et al. Palmitic acid dysregulates the Hippo-YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS-STING-IRF3 signaling mechanism. J Biol Chem. 2017;292:15002-15015 pubmed publisher
    ..migration, and tube formation, which were associated with increased expression of mammalian Ste20-like kinases 1 (MST1), YAP phosphorylation/inactivation, and nuclear exclusion...
  14. Zhang T, Zhang G, Jin Y, Guo Y, Wang Z, Fan Y, et al. Energy restriction affect liver development in Hu sheep ram lambs through Hippo signaling pathway. Tissue Cell. 2017;49:603-611 pubmed publisher
    ..05). Moreover, Hippo signaling pathway proteins [mammalian sterile 20-like protein kinase 1 (MST1), large tumor suppressor kinase 1 (LATS1), and yes-associated protein 1 (YAP1)] were mainly observed around the ..
  15. Chu P, He L, Xiong L, Luo L, Huang R, Liao L, et al. Molecular cloning, expression analysis and localization pattern of the MST family in grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2018;76:316-323 pubmed publisher
    ..protein kinase superfamily, has five members that can be found in mammals: STK3 (also called MST2), STK4 (MST1), STK24 (MST3), STK25 (YSK1 or SOK1), and STK26 (MST4)...
  16. El Husseini N, Hales B. The Roles of P53 and Its Family Proteins, P63 and P73, in the DNA Damage Stress Response in Organogenesis-Stage Mouse Embryos. Toxicol Sci. 2018;162:439-449 pubmed publisher
    ..Together, our data show that P53 is the principal P53 family member that is activated in the embryonic DNA damage response. ..
  17. Sugihara T, Werneburg N, Hernandez M, Yang L, Kabashima A, Hirsova P, et al. YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells Are Regulated by LCK and Independent of LATS Activity. Mol Cancer Res. 2018;16:1556-1567 pubmed publisher
    ..YAP is known to be regulated by a serine/threonine kinase relay module (MST1/2-LATS1/2) culminating in phosphorylation of YAP at Serine 127 and cytoplasmic sequestration...
  18. Lin K, Moroishi T, Meng Z, Jeong H, Plouffe S, Sekido Y, et al. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2017;19:996-1002 pubmed publisher
    ..The core Hippo components in mammals are composed of the upstream serine/threonine kinases Mst1/2, MAPK4Ks and Lats1/2...
  19. Chattopadhyay A, Pinkaew D, Doan H, Jacob R, Verma S, Friedman H, et al. Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice. Sci Rep. 2016;6:18701 pubmed publisher
    ..proteasome-mediated degradation, and keeps it enzymatically active by blocking its deactivating phosphorylation by Mst1, a serine/threonine kinase...
  20. Saito A, Nagase T. Hippo and TGF-β interplay in the lung field. Am J Physiol Lung Cell Mol Physiol. 2015;309:L756-67 pubmed publisher
    The Hippo pathway is comprised of a kinase cascade that involves mammalian Ste20-like serine/threonine kinases (MST1/2) and large tumor suppressor kinases (LATS1/2) and leads to inactivation of transcriptional coactivator with PDZ-binding ..
  21. Yu L, Liu Y, Jin Y, Cao X, Chen J, Jin J, et al. Lentivirus-Mediated HDAC3 Inhibition Attenuates Oxidative Stress in APPswe/PS1dE9 Mice. J Alzheimers Dis. 2018;61:1411-1424 pubmed publisher
    ..Moreover, HDAC3 inhibition inactivated the c-Abl/MST1/YAP signaling pathway in the hippocampi of APP/PS1 mice...
  22. Sukumaran S, Stumpf M, Salamon S, Ahmad I, Bhattacharya K, Fischer S, et al. CDK5RAP2 interaction with components of the Hippo signaling pathway may play a role in primary microcephaly. Mol Genet Genomics. 2017;292:365-383 pubmed publisher
    ..We further identified an interaction of CDK5RAP2 with the Hippo pathway components MST1 kinase and the transcriptional regulator TAZ...
  23. Mikheyeva I, Grady P, Tamburini F, Lorenz D, Cam H. Multifaceted genome control by Set1 Dependent and Independent of H3K4 methylation and the Set1C/COMPASS complex. PLoS Genet. 2014;10:e1004740 pubmed publisher
    ..role for Set1C and H3K4me in mediating the clustering of Tf2s into Tf bodies by antagonizing the acetyltransferase Mst1-mediated H3K4 acetylation...
  24. Cheng J, Wang E, Yi Y, Thakur A, Tsai S, Hoodless P. S1P Stimulates Proliferation by Upregulating CTGF Expression through S1PR2-Mediated YAP Activation. Mol Cancer Res. 2018;16:1543-1555 pubmed publisher
    ..Of note, S1P activates YAP in a MST1/2-independent manner suggesting that the canonical Hippo kinase is not required for S1P-mediated proliferation in ..
  25. Jiang L, Li W, Wu M, Cao S. Ciculating miRNA-21 as a Biomarker Predicts Polycystic Ovary Syndrome (PCOS) in Patients. Clin Lab. 2015;61:1009-15 pubmed
    ..In PCOS patients, the expression levels of MST1/2, LATS1/2, TAZ were much lower than the control subjects...
  26. He Z, Zhao T, Jin F, Li J, Xu Y, Dong H, et al. Downregulation of RASSF6 promotes breast cancer growth and chemoresistance through regulation of Hippo signaling. Biochem Biophys Res Commun. 2018;503:2340-2347 pubmed publisher
    ..In addition, RASSF6 activated Hippo signaling pathway by upregulating MST1/2 and LATS1 phosphorylation...
  27. Palus S, von Haehling S, Springer J. Muscle wasting: an overview of recent developments in basic research. Int J Cardiol. 2014;176:640-4 pubmed publisher
    ..the elongin BC ubiquitin-ligase, Cbl-b, culling 7, Fbxo40, MG53 (TRIM72) and the mitochondrial Mul1, 2) the kinase MST1 and 3) the G-protein Gαi2...
  28. Liangpunsakul S, Lai X, Ross R, Yu Z, Modlik E, Westerhold C, et al. Novel serum biomarkers for detection of excessive alcohol use. Alcohol Clin Exp Res. 2015;39:556-65 pubmed publisher
    ..protein 4B (ARID4B), phosphatidylcholine-sterol acyltransferase (LCAT), hepatocyte growth factor-like protein (MST1), and ADP-ribosylation factor 6 (ARL6)...
  29. Nimmo E, Prendergast J, Aldhous M, Kennedy N, Henderson P, Drummond H, et al. Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway. Inflamm Bowel Dis. 2012;18:889-99 pubmed publisher
    ..6-fold [P = 0.021] in adults; 2.4-fold [P = 0.009] in adults and children combined), including IL-27, IL-19, TNF, MST1, and NOD2. Methylation status was predictive of disease status (sensitivity 0.71, specificity 0.83)...
  30. Kluge J, Kück U. AcAxl2 and AcMst1 regulate arthrospore development and stress resistance in the cephalosporin C producer Acremonium chrysogenum. Curr Genet. 2018;64:713-727 pubmed publisher
    ..protein Axl2 (axial budding pattern protein 2), a central component of the bud site selection system (BSSS) and Mst1 (mammalian Sterile20-like kinase), a septation initiation network (SIN)-associated germinal center kinase (GCK)...
  31. Chen Z, Shi H, Sun S, Luo J, Zhang W, Hou Y, et al. MiR-183 regulates milk fat metabolism via MST1 in goat mammary epithelial cells. Gene. 2018;646:12-19 pubmed publisher
    ..Using Western blot, we demonstrate that MST1, one of the major elements of the Hippo signaling pathway, is a target of miR-183...
  32. Qi Q, Li D, Luo H, Guan K, Ye K. Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability. Proc Natl Acad Sci U S A. 2015;112:7255-60 pubmed publisher
    ..abrogating cancer cell progression by netrin-1, whereas knockdown of mammalian STE20-like protein kinase 1/2 (MST1/2) or large tumor suppressor kinase 1/2 (Lats1/2), two sets of upstream core kinases of the Hippo pathway, has no ..
  33. Zhang H, Geng D, Gao J, Qi Y, Shi Y, Wang Y, et al. Expression and significance of Hippo/YAP signaling in glioma progression. Tumour Biol. 2016;: pubmed
    ..Unexpectedly, both the mRNA and protein levels of MST1/2 increased in the glioma tissues, inconsistent with its presumed tumor suppressor identity...
  34. Servas C, Kiehlmeier S, Hach J, Gross R, Götz C, Montenarh M. The mammalian STE20-like kinase 1 (MST1) is a substrate for the apoptosis inhibiting protein kinase CK2. Cell Signal. 2017;36:163-175 pubmed publisher
    ..The mammalian Sterile 20-like kinase 1 (MST1) is a pro-apoptotic protein kinase, which is activated and cleaved by caspases upon the induction of cell stress...
  35. Shi L, Lei J, Xu H, Zheng J, Wang Y, Peng Y, et al. Hydrogen sulfide ameliorates subarachnoid hemorrhage-induced neuronal apoptosis via the ROS-MST1 pathway. Oncotarget. 2017;8:73547-73558 pubmed publisher
    ..Hydrogen sulfide (H2S) has shown a neuroprotective role in several cerebrovascular diseases. This study aimed to explore the underlying mechanisms of H2S in early brain injury after subarachnoid hemorrhage (SAH)...
  36. Cleynen I, Juni P, Bekkering G, Nüesch E, Mendes C, Schmied S, et al. Genetic evidence supporting the association of protease and protease inhibitor genes with inflammatory bowel disease: a systematic review. PLoS ONE. 2011;6:e24106 pubmed publisher
    ..16 ranked highest, followed by acylaminoacyl-peptidase (APEH), dystroglycan (DAG1), macrophage-stimulating protein (MST1) and ubiquitin-specific peptidase 4 (USP4), all located on chromosome 3...
  37. Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, et al. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nat Immunol. 2015;16:1142-52 pubmed publisher
    ..Here we found that the kinases Mst1 and Mst2 functioned to control ROS production by regulating mitochondrial trafficking and mitochondrion-phagosome ..
  38. Lee D, Kim T, Lee D, Lim D. Mammalian sterile 20 kinase 1 and 2 are important regulators of hematopoietic stem cells in stress condition. Sci Rep. 2018;8:942 pubmed publisher
    ..b>MST1 and MST2 (MST1/2) are core serine-threonine kinases in the Hippo signaling pathway, one of which, MST1, has been ..
  39. Khanal P, Jia Z, Yang X. Cysteine residues are essential for dimerization of Hippo pathway components YAP2L and TAZ. Sci Rep. 2018;8:3485 pubmed publisher
    ..Recent studies reported that human serine/threonine protein kinase, Mst1, a core component of the Hippo pathway can be activated through formation of homodimer...
  40. Zhang X, Guo C, Wu X, Li A, Liu L, Tsark W, et al. Analysis of Liver Tumor-Prone Mouse Models of the Hippo Kinase Scaffold Proteins RASSF1A and SAV1. Cancer Res. 2016;76:2824-35 pubmed publisher
    ..As a binding partner of the kinases MST1 and MST2, the mammalian orthologs of the Drosophila Hippo kinase, RASSF1A is a potential regulator of the Hippo ..
  41. Li C, Bi Y, Li Y, Yang H, Yu Q, Wang J, et al. Dendritic cell MST1 inhibits Th17 differentiation. Nat Commun. 2017;8:14275 pubmed publisher
    ..T-cell differentiation in autoimmune and antifungal inflammation and find that mammalian sterile 20-like kinase 1 (MST1) signalling from DCs negatively regulates IL-17 producing-CD4+T helper cell (Th17) differentiation...
  42. Perumal N, Perumal M, Halagowder D, Sivasithamparam N. Morin attenuates diethylnitrosamine-induced rat liver fibrosis and hepatic stellate cell activation by co-ordinated regulation of Hippo/Yap and TGF-?1/Smad signaling. Biochimie. 2017;140:10-19 pubmed publisher
    ..Morin activated hippo signaling through significantly increased expression of Mst1 and Lats1 with decreased expression of transcriptional effectors Yap/TAZ, thereby prevented HSC activation and also ..
  43. Lee K, Yonehara S. Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J Biol Chem. 2002;277:12351-8 pubmed
  44. Li Y, Zhou H, Li F, Chan S, Lin Z, Wei Z, et al. Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway. Cell Res. 2015;25:801-17 pubmed publisher
    The tumor suppressor Merlin/NF2 functions upstream of the core Hippo pathway kinases Lats1/2 and Mst1/2, as well as the nuclear E3 ubiquitin ligase CRL4(DCAF1)...
  45. Ye H, Li X, Zheng T, Hu C, Pan Z, Huang J, et al. The Hippo Signaling Pathway Regulates Ovarian Function via the Proliferation of Ovarian Germline Stem Cells. Cell Physiol Biochem. 2017;41:1051-1062 pubmed publisher
    ..Thus, the isolated cells were preliminarily identified as OGSCs. (2) The co-expression of LATS2, MST1, YAP1 and MVH was observed in isolated OGSCs...
  46. Ashokkumar R, Jamuna S, Sakeena Sadullah M, Niranjali Devaraj S. Vitexin protects isoproterenol induced post myocardial injury by modulating hipposignaling and ER stress responses. Biochem Biophys Res Commun. 2018;496:731-737 pubmed publisher
    ..Further results have demonstrated that, activation of Mst1 through ER stress was diminished upon treatment with Vitexin...
  47. Archibald A, Al Masri M, Liew Spilger A, McCaffrey L. Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling. Mol Biol Cell. 2015;26:3578-95 pubmed publisher
    ..aPKC associated with Mst1/2, which uncoupled Mst1/2 from Lats1/2 and promoted nuclear accumulation of Yap1...
  48. Kurz A, Pruenster M, Rohwedder I, Ramadass M, Schäfer K, Harrison U, et al. MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. J Clin Invest. 2016;126:4125-4139 pubmed publisher
    ..Recent findings have associated mammalian sterile 20-like kinase 1 (MST1) loss of function with a human primary immunodeficiency disorder, suggesting that MST1 may be involved in immune ..
  49. Sasi N, Bhutkar A, Lanning N, Mackeigan J, Weinreich M. DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways. Neoplasia. 2017;19:439-450 pubmed publisher
    ..Characterization of one novel hit, the LATS2 tumor suppressor, suggests that it promotes apoptosis independently of the upstream MST1/2 kinases in the Hippo signaling pathway.
  50. Roh K, Choi E. TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1. Free Radic Biol Med. 2016;91:105-13 pubmed publisher
    ..In particular, excessive ROS causes oxidative stress that leads to cell death. The mammalian STE20-like kinase-1 (MST1), a multifunctional serine-threonine kinase, plays a pivotal role in oxidative stress-induced cellular signaling ..
  51. Wang T, Zhang L, Hu J, Duan Y, Zhang M, Lin J, et al. Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement. J Mol Cell Cardiol. 2016;98:108-16 pubmed publisher
    ..Here ApoE(-/-) mice were crossed with Mst1 knockout or Mst1 Tg mice to generate ApoE(-/-):Mst1(-/-) and ApoE(-/-):Mst1Tg mice...
  52. Lv B, Zhang L, Miao R, Xiang X, Dong S, Lin T, et al. Comprehensive analysis and experimental verification of LINC01314 as a tumor suppressor in hepatoblastoma. Biomed Pharmacother. 2018;98:783-792 pubmed publisher
    ..investigations revealed that LINC01314 overexpression inhibited nuclear translocation of YAP, by inducing MST1 expression and promoting phosphorylation of LATS1 and YAP, consequently downregulating the expression of cell cycle ..
  53. Liu L, Baier K, Dammann R, Pfeifer G. The tumor suppressor RASSF1A does not interact with Cdc20, an activator of the anaphase-promoting complex. Cell Cycle. 2007;6:1663-5 pubmed
    ..Here, we have used different methods to investigate the association of RASSF1A and Cdc20. We show that there is no interaction between RASSF1A and Cdc20 and conclude that further investigation of the mitotic role of RASSF1A is required. ..
  54. Holman K, Wu J, Ling J, Simonovic M. The crystal structure of yeast mitochondrial ThrRS in complex with the canonical threonine tRNA. Nucleic Acids Res. 2016;44:1428-39 pubmed publisher
    In mitochondria of Saccharomyces cerevisiae, a single aminoacyl-tRNA synthetase (aaRS), MST1, aminoacylates two isoacceptor tRNAs, tRNA1(Thr) and tRNA2(Thr), that harbor anticodon loops of different size and sequence...
  55. Tong R, Yang B, Xiao H, Peng C, Hu W, Weng X, et al. KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling. Oncotarget. 2017;8:37717-37729 pubmed publisher
    ..Base on the enhanced Hippo pathway, KCTD11 could activate p21 by stabilizing p53 or promoting the MST1/ GSK3β/p21 signaling in HCC...
  56. Constantinescu Aruxandei D, Makbul C, Koturenkiene A, Lüdemann M, Herrmann C. Dimerization-induced folding of MST1 SARAH and the influence of the intrinsically unstructured inhibitory domain: low thermodynamic stability of monomer. Biochemistry. 2011;50:10990-1000 pubmed publisher
    The serine/threonine mammalian sterile 20-like kinase (MST1) is involved in promotion of caspase-dependent and independent apoptosis. Phosphorylation and oligomerization are required for its activation...
  57. Abdollahpour H, Appaswamy G, Kotlarz D, Diestelhorst J, Beier R, Schäffer A, et al. The phenotype of human STK4 deficiency. Blood. 2012;119:3450-7 pubmed publisher
    ..Homozygosity mapping and candidate gene sequencing revealed a homozygous premature termination mutation in the gene STK4 (serine threonine kinase 4, formerly having the symbol MST1)...
  58. Thompson B, Sahai E. MST kinases in development and disease. J Cell Biol. 2015;210:871-82 pubmed publisher
    ..MST kinase family, which is related to the Hippo kinase in Drosophila melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called STK3), MST3 (also called STK24), MST4, and YSK1 (also called STK25 or SOK1)...
  59. Li L, Fang R, Liu B, Shi H, Wang Y, Zhang W, et al. Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth. Oncogene. 2016;35:4048-57 pubmed publisher
    Reduction or loss of tumor-suppressor mammalian STE20-like kinase 1 (MST1) in Hippo pathway contributes to the tumorigenesis. However, the mechanism leading to reduction of MST1 in cancers remains poorly understood...
  60. Yuan L, Li Z. [Research advances in the role of the Hippo signaling pathway in pathogenesis of liver cancer]. Zhonghua Gan Zang Bing Za Zhi. 2017;25:797-800 pubmed publisher
    The Hippo signaling pathway consists of four core components in mammals, i.e., Mst1/2, WW45, Mob1, and LATS1/2, which can inhibit the transcriptional coactivator YAP from entering the nucleus, maintain the balance between cell ..
  61. Zheng Y, Liu B, Wang L, Lei H, Pulgar Prieto K, Pan D. Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex. Cell Rep. 2017;21:3612-3623 pubmed publisher
    ..pathway controls organ size and tissue homeostasis through a kinase cascade leading from the Ste20-like kinase Hpo (MST1/2 in mammals) to the transcriptional coactivator Yki (YAP/TAZ in mammals)...
  62. Callus B, Verhagen A, Vaux D. Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. FEBS J. 2006;273:4264-76 pubmed
    ..Hpo most closely resembles the pro-apoptotic mammalian sterile20 kinases 1 and 2 (Mst1 and 2), and Salvador (Sav) has a human orthologue hSav (also called hWW45)...
  63. Xiong S, Couzens A, Kean M, Mao D, Guettler S, Kurinov I, et al. Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation. Mol Cell Proteomics. 2017;16:1111-1125 pubmed publisher
    ..Human MOB1 binds both the upstream kinases MST1 and MST2 and the downstream AGC group kinases LATS1, LATS2, NDR1, and NDR2...
  64. Bae S, Ni L, Osinski A, Tomchick D, Brautigam C, Luo X. SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK. elife. 2017;6: pubmed publisher
    ..Here, we discover SAV1-mediated inhibition of the PP2A complex STRIPAKSLMAP as a key mechanism of MST1/2 activation...
  65. Glantschnig H, Rodan G, Reszka A. Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation. J Biol Chem. 2002;277:42987-96 pubmed
    b>MST1 is a member of the Sterile-20 family of cytoskeletal, stress, and apoptotic kinases. MST1 is activated by phosphorylation at previously unidentified sites...
  66. de Souza P, Lindsay M. Mammalian Sterile20-like kinase 1 and the regulation of apoptosis. Biochem Soc Trans. 2004;32:485-8 pubmed
    Mammalian Sterile20-like kinase 1 (Mst1) is a ubiquitously expressed serine/threonine kinase which represents a member of the rapidly expanding family of enzymes related to the yeast Sterile20 kinase...
  67. Hergovich A, Hemmings B. Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling. Biofactors. 2009;35:338-45 pubmed publisher
    ..In this review, we summarize current knowledge of Merlin/MST/SAV/MOB/LATS/NDR/YAP/TAZ networks (also termed mammalian Hippo signaling) and their roles in mammalian cellular transformation. ..
  68. Yuan F, Xie Q, Wu J, Bai Y, Mao B, Dong Y, et al. MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation. J Biol Chem. 2011;286:6940-5 pubmed publisher
    Mammalian Sterile 20-like kinase 1 (MST1) protein kinase plays an important role in the apoptosis induced by a variety of stresses...
  69. Xu C, Liu C, Huang W, Tu S, Wan F. Effect of Mst1 overexpression on the growth of human hepatocellular carcinoma HepG2 cells and the sensitivity to cisplatin in vitro. Acta Biochim Biophys Sin (Shanghai). 2013;45:268-79 pubmed publisher
    Mammalian STE20-like kinase 1 (Mst1) is the mammalian homologue of Drosophila Hippo, a major inhibitor of cell proliferation in Drosophila...
  70. Kim M, Kim M, Lee M, Kim C, Lim D. The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis. Nat Commun. 2014;5:5370 pubmed publisher
    ..Here we show that the MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis...
  71. Rawat S, Araiza Olivera D, Arias Romero L, Villamar Cruz O, Prudnikova T, Roder H, et al. H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization. Curr Biol. 2016;26:1556-1563 pubmed publisher
    The protein kinases Mst1 and Mst2 have tumor suppressor activity, but their mode of regulation is not well established...
  72. Perumal N, Perumal M, Kannan A, Subramani K, Halagowder D, Sivasithamparam N. Morin impedes Yap nuclear translocation and fosters apoptosis through suppression of Wnt/?-catenin and NF-?B signaling in Mst1 overexpressed HepG2 cells. Exp Cell Res. 2017;355:124-141 pubmed publisher
    ..Of the known multiple schemes to inhibit Yap activity, activation of Mammalian Sterile 20-like Kinase 1 (Mst1), an upstream regulator of Yap, appears to be a promising one...
  73. Ji F, Guo B, Wang N, Zhong C, Huang L, Huang Y, et al. Pyruvate kinase M2 interacts with mammalian sterile 20-like kinase 1 and inhibits tamoxifen-induced apoptosis in human breast cancer cells. Tumour Biol. 2017;39:1010428317692251 pubmed publisher
  74. Cheow E, Cheng W, Yap T, Dutta B, Lee C, Kleijn D, et al. Myocardial Injury Is Distinguished from Stable Angina by a Set of Candidate Plasma Biomarkers Identified Using iTRAQ/MRM-Based Approach. J Proteome Res. 2017;: pubmed publisher
    ..proteins associated with atherosclerotic stable angina that were implicated in endothelial dysfunction (F10 and MST1), proteins associated with myocardial injury reportedly involved in plaque destabilization (SERPINA3, CPN2, LUM), ..
  75. Creasy C, Chernoff J. Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene. 1995;167:303-6 pubmed
    ..MST2 is most similar to the previously identified MST1 protein kinase (78% identity, 88% similarity)...
  76. Grigorian M, Lukanidin E. [Activator of metastasis in cancer cells, Mst1/S100A4 protein binds to tumor suppressor protein p53]. Genetika. 2003;39:900-8 pubmed
    ..Thus, Mts1 promotes selection of more aggressive, metastatic phenotype during tumor progression. ..
  77. Oh H, Lee K, Song S, Jin M, Song M, Lee J, et al. Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. Cancer Res. 2006;66:2562-9 pubmed
    Mammalian sterile 20-like kinase 1 (Mst1) is activated by both caspase-mediated cleavage and phosphorylation in response to apoptotic stimuli, including Fas ligation...
  78. Nehme N, Schmid J, Debeurme F, Andre Schmutz I, Lim A, Nitschke P, et al. MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival. Blood. 2012;119:3458-68 pubmed publisher
    ..In the present study, we report a primary immunodeficiency phenotype associated with MST1 deficiency and primarily characterized by a progressive loss of naive T cells...
  79. Yang Y, Wang L, Wu Y, Su D, Wang N, Wang J, et al. Tanshinol suppresses inflammatory factors in a rat model of vascular dementia and protects LPS-treated neurons via the MST1-FOXO3 signaling pathway. Brain Res. 2016;1646:304-314 pubmed publisher
    ..Our previous work showed that mammalian Ste20-like kinase 1 (MST1) and the gene for a downstream transcription factor, FOXO3, play major roles in lipopolysaccharide (LPS)-induced ..
  80. Kwan J, Sczaniecka A, Heidary Arash E, Nguyen L, Chen C, Ratkovic S, et al. DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Genes Dev. 2016;30:2696-2709 pubmed publisher
    ..role of DLG5 in the formation of protein assemblies containing core Hippo kinases mammalian ste20 homologs 1/2 (MST1/2) and Par-1 polarity proteins microtubule affinity-regulating kinases 1/2/3 (MARK1/2/3)...
  81. Praskova M, Xia F, Avruch J. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol. 2008;18:311-21 pubmed publisher
    b>MST1 and MST2 are the mammalian Ste20-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development...
  82. Cooper W, Hesson L, Matallanas D, Dallol A, von Kriegsheim A, Ward R, et al. RASSF2 associates with and stabilizes the proapoptotic kinase MST2. Oncogene. 2009;28:2988-98 pubmed publisher
    ..We identified the proapoptotic kinases, MST1 and MST2, as the most significant binding partners of RASSF2, confirmed the interactions at endogenous levels and ..
  83. Yu F, Zhao B, Panupinthu N, Jewell J, Lian I, Wang L, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012;150:780-91 pubmed publisher
    ..Our study identifies extracellular diffusible signals that modulate the Hippo pathway and also establishes the Hippo-YAP pathway as a critical signaling branch downstream of GPCR. ..
  84. Guo Z, Li G, Bian E, Ma C, Wan J, Zhao B. TGF-?-mediated repression of MST1 by DNMT1 promotes glioma malignancy. Biomed Pharmacother. 2017;94:774-780 pubmed publisher
    ..Here, we showed that TGF-? induced the downregulation of MST1 expression in U87 and U251 glioma cells...
  85. Arimori T, Kitago Y, Umitsu M, Fujii Y, Asaki R, Tamura Kawakami K, et al. Fv-clasp: An Artificially Designed Small Antibody Fragment with Improved Production Compatibility, Stability, and Crystallizability. Structure. 2017;25:1611-1622.e4 pubmed publisher
    ..By fusing an anti-parallel coiled-coil structure derived from the SARAH domain of human Mst1 kinase to the variable region of an antibody, we succeeded in creating a novel chimeric antibody fragment of ∼..
  86. Li D, Ni H, Rui Q, Gao R, Chen G. Deletion of Mst1 attenuates neuronal loss and improves neurological impairment in a rat model of traumatic brain injury. Brain Res. 2018;1688:15-21 pubmed publisher
    ..In our work, we explored the functions of Mammalian STE20-like kinase-1 (Mst1), a apoptosis-promoting kinase and also a pivotal bridgebuilder of apoptotic signaling, in the etiopathogenesis of ..
  87. Karakadze M, Hirt P, Wikramanayake T. The Genetic Basis of Seborrheic Dermatitis: A Review. J Eur Acad Dermatol Venereol. 2017;: pubmed publisher
    ..Most of the encoded proteins play a role either in the immune response (ACT1, C5, IKBKG/NEMO, STK4, 2C TCR) or epidermal differentiation (ZNF750, MPZL3)...
  88. Schultz S, Nigg E. Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. Cell Growth Differ. 1993;4:821-30 pubmed
  89. Zhou Y, Adolfs Y, Pijnappel W, Fuller S, van der Schors R, Li K, et al. MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis. Mol Cell Biol. 2011;31:3603-15 pubmed publisher
    ..NDR1/2 kinases are known to mediate apoptosis downstream of the mammalian Ste-20-like kinase MST1, and ablation of NDR1 in mice predisposes the mice to cancer as a result of compromised apoptosis...
  90. Yu J, Zhai X, Li X, Zhong C, Guo C, Yang F, et al. Identification of MST1 as a potential early detection biomarker for colorectal cancer through a proteomic approach. Sci Rep. 2017;7:14265 pubmed publisher
    ..7% and sensitivity of 92.3% in a blind test. The candidate biomarker serine/threonine kinase 4 (STK4, also known as MST1) was identified by Tandem mass spectrometry (MS/MS) and verified with western blotting and ..
  91. Rabizadeh S, Xavier R, Ishiguro K, Bernabeortiz J, Lopez Ilasaca M, Khokhlatchev A, et al. The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. J Biol Chem. 2004;279:29247-54 pubmed
    ..CNK1-induced apoptosis is suppressed by a dominant inhibitor of the mammalian sterile 20 kinases 1 and (MST1/MST2)...
  92. Wen W, Zhu F, Zhang J, Keum Y, Zykova T, Yao K, et al. MST1 promotes apoptosis through phosphorylation of histone H2AX. J Biol Chem. 2010;285:39108-16 pubmed publisher
    b>MST1 (mammalian STE20-like kinase 1) is a serine/threonine kinase that is cleaved and activated by caspases during apoptosis...