STK38

Summary

Gene Symbol: STK38
Description: serine/threonine kinase 38
Alias: NDR, NDR1, serine/threonine-protein kinase 38, NDR1 protein kinase, Ndr Ser/Thr kinase-like protein, nuclear Dbf2-related kinase 1
Species: human
Products:     STK38

Top Publications

  1. Chiba S, Ikeda M, Katsunuma K, Ohashi K, Mizuno K. MST2- and Furry-mediated activation of NDR1 kinase is critical for precise alignment of mitotic chromosomes. Curr Biol. 2009;19:675-81 pubmed publisher
    ..b>NDR1 is an evolutionarily conserved serine/threonine kinase whose activity is regulated by MST kinases, Furry (Fry), and ..
  2. Koike Kumagai M, Yasunaga K, Morikawa R, Kanamori T, Emoto K. The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway. EMBO J. 2009;28:3879-92 pubmed publisher
    ..In Drosophila class IV dendrite arborization (da) neurons, the NDR family kinase Tricornered (Trc) is required for homotypic repulsion of dendrites that facilitates dendritic tiling...
  3. Cornils H, Kohler R, Hergovich A, Hemmings B. Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability. Mol Cell Biol. 2011;31:1382-95 pubmed publisher
    ..duplication, and mitotic chromosome alignment downstream of the HIPPO pathway components MST1 and MST2, mammalian NDR kinases have been implicated to function in cell cycle-dependent processes...
  4. Zhou Y, Adolfs Y, Pijnappel W, Fuller S, van der Schors R, Li K, et al. MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis. Mol Cell Biol. 2011;31:3603-15 pubmed publisher
    ..b>NDR1/2 kinases are known to mediate apoptosis downstream of the mammalian Ste-20-like kinase MST1, and ablation of NDR1 ..
  5. Vichalkovski A, Gresko E, Cornils H, Hergovich A, Schmitz D, Hemmings B. NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis. Curr Biol. 2008;18:1889-95 pubmed publisher
    Human NDR1 and 2 (NDR1/2) are serine-threonine protein kinases in a subgroup of the AGC kinase family. The mechanisms of physiological NDR1/2 activation and their function remain largely unknown...
  6. Cornils H, Stegert M, Hergovich A, Hynx D, Schmitz D, Dirnhofer S, et al. Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma. Sci Signal. 2010;3:ra47 pubmed publisher
    ..Defective apoptosis contributes to the development of various human malignancies. The kinases nuclear Dbf2-related 1 (NDR1) and NDR2 mediate apoptosis downstream of the tumor suppressor proteins RASSF1A (Ras association domain family ..
  7. Ultanir S, Hertz N, Li G, Ge W, Burlingame A, Pleasure S, et al. Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Neuron. 2012;73:1127-42 pubmed publisher
    ..The evolutionarily conserved NDR1/2 kinase pathway, important for polarized growth from yeast to mammals, controls dendrite growth and morphology in ..
  8. Jacometo C, Zhou Z, Luchini D, Trevisi E, Corrêa M, Loor J. Maternal rumen-protected methionine supplementation and its effect on blood and liver biomarkers of energy metabolism, inflammation, and oxidative stress in neonatal Holstein calves. J Dairy Sci. 2016;99:6753-6763 pubmed publisher
  9. Zhang H, Chen R, Sun G, Yang L, Zhu Y, Xu X, et al. Protective effects of total flavonoids from Clinopodium chinense (Benth.) O. Ktze on myocardial injury in vivo and in vitro via regulation of Akt/Nrf2/HO-1 pathway. Phytomedicine. 2018;40:88-97 pubmed publisher
    ..TFCC protects against myocardial injury and enhances cellular antioxidant defense capacity by inducing the phosphorylation of AKT, which subsequently activated the Nrf2/HO-1 signaling pathway. ..

More Information

Publications136 found, 100 shown here

  1. Lee T, Bai K, Chen Y, Lee T, Chung C, Tsai W, et al. Histone deacetylase inhibition of cardiac autophagy in rats on a high?fat diet with low?dose streptozotocin-induced type 2 diabetes mellitus. Mol Med Rep. 2017;: pubmed publisher
    ..The present study demonstrated that MPT0E014 may improve cardiac function in T2DM rats by modulating myocardial autophagy, inflammation and insulin signaling...
  2. Oishi K, Yamamoto S, Itoh N, Nakao R, Yasumoto Y, Tanaka K, et al. Wheat alkylresorcinols suppress high-fat, high-sucrose diet-induced obesity and glucose intolerance by increasing insulin sensitivity and cholesterol excretion in male mice. J Nutr. 2015;145:199-206 pubmed publisher
  3. Wang Z, Li R, Zhong R. Extracellular matrix promotes proliferation, migration and adhesion of airway smooth muscle cells in a rat model of chronic obstructive pulmonary disease via upregulation of the PI3K/AKT signaling pathway. Mol Med Rep. 2018;18:3143-3152 pubmed publisher
    ..In conclusion, ECM proteins promoted proliferation, migration and adhesion of ASMCs form rat models of COPD through activation of the PI3K/AKT signaling pathway. ..
  4. Canet Pons J, Schubert R, Duecker R, Schrewe R, Wölke S, Kieslich M, et al. Ataxia telangiectasia alters the ApoB and reelin pathway. Neurogenetics. 2018;19:237-255 pubmed publisher
    ..As extracellular factors, apolipoproteins and their cargo such as vitamin E may be useful for neuroprotective interventions. ..
  5. Salama A, Duque M, Wang L, Shahzad K, Olivera M, Loor J. Enhanced supply of methionine or arginine alters mechanistic target of rapamycin signaling proteins, messenger RNA, and microRNA abundance in heat-stressed bovine mammary epithelial cells in vitro. J Dairy Sci. 2019;102:2469-2480 pubmed publisher
    ..The positive responses with Met and Arg raise the possibility that supplementation with these AA during HS might have a positive effect on mammary metabolism. ..
  6. Koronowicz A, Drozdowska M, Banks P, Piasna Słupecka E, Domagała D, Leszczyńska T. Fatty Acids of CLA-enriched Egg Yolks Can Induce Mitochondrial Pathway of Apoptosis in MCF-7 Breast Cancer Cells. Anticancer Res. 2018;38:2861-2870 pubmed
    ..Taken together, our results suggest that activation of the mitochondrial apoptotic pathway may be a potential mechanism of EFA-CLA action. ..
  7. Berner D, Zenkel M, Pasutto F, Hoja U, Liravi P, Gusek Schneider G, et al. Posttranscriptional Regulation of LOXL1 Expression Via Alternative Splicing and Nonsense-Mediated mRNA Decay as an Adaptive Stress Response. Invest Ophthalmol Vis Sci. 2017;58:5930-5940 pubmed publisher
  8. Liu Y, Yu Q, Chen Y. Effect of silibinin on CFLAR-JNK pathway in oleic acid-treated HepG2 cells. Biomed Pharmacother. 2018;108:716-723 pubmed publisher
  9. Greer Y, Gao B, Yang Y, Nussenzweig A, Rubin J. Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1. PLoS ONE. 2017;12:e0170903 pubmed publisher
    ..Together, these findings suggest that CK1? contributes to the efficient repair of DNA damage and the proper functioning of mitotic checkpoints by maintaining appropriate levels of Chk1. ..
  10. Shi T, Sun J, Wu X, Weng J, Wang P, Qie H, et al. Transcriptome analysis of Chinese bayberry (Myrica rubra Sieb. et Zucc.) fruit treated with heat and 1-MCP. Plant Physiol Biochem. 2018;133:40-49 pubmed publisher
    ..These results might improve our understanding of the mechanisms of heat and 1-MCP inhibition of fruit postharvest physiology and prolongation of fruit shelf life. ..
  11. Singh S, Tao S, Fields T, Webb S, Harris R, Rao R. Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice. Dis Model Mech. 2015;8:931-40 pubmed publisher
  12. Suliman H, Kraft B, Bartz R, Chen L, Welty Wolf K, Piantadosi C. Mitochondrial quality control in alveolar epithelial cells damaged by S. aureus pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2017;313:L699-L709 pubmed publisher
    ..These findings imply that mitochondrial QC activation in pneumonia-damaged AT2 cells promotes cell survival in support of alveolar function. ..
  13. Yang B, Lan S, Dieudé M, Sabo Vatasescu J, Karakeussian Rimbaud A, Turgeon J, et al. Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2018;29:1900-1916 pubmed publisher
    ..These findings also demonstrate the predominant role of microvascular over tubular injury as a driver of progressive renal damage and fibrosis after IRI. ..
  14. Saito Y, Moriya S, Kazama H, Hirasawa K, Miyahara K, Kokuba H, et al. Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis. Int J Oncol. 2018;52:1165-1177 pubmed publisher
    ..Therefore, the enhanced cytotoxic effect of GEF under AAS culture conditions is thought to be mediated by atypical necroptosis. ..
  15. Cheng H, Xia B, Su C, Chen K, Chen X, Chen P, et al. PI3K/Akt signaling pathway and Hsp70 activate in hippocampus of rats with chronic manganese sulfate exposure. J Trace Elem Med Biol. 2018;50:332-338 pubmed publisher
    ..05). Chronic MnSO4 exposure can result in apoptosis of central nerve cells, activate the PI3K/Akt signaling pathway in rats' hippocampus, and upregulate Hsp70 transcription and translation. ..
  16. Moraes P, Yonamine C, Pinto Junior D, Esteves J, Machado U, Mori R. Insulin acutely triggers transcription of Slc2a4 gene: participation of the AT-rich, E-box and NFKB-binding sites. Life Sci. 2014;114:36-44 pubmed publisher
    ..These results unravel how post-prandial increase of insulin may guarantee GLUT4 expression, and how the insulin signaling impairment can participate in insulin resistance-induced repression of GLUT4. ..
  17. Pagel R, Bär F, Schröder T, Sünderhauf A, Künstner A, Ibrahim S, et al. Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine. FASEB J. 2017;31:4707-4719 pubmed publisher
    ..König, P., Tsang, A. H., Bettenworth, D., Divanovic, S., Lehnert, H., Fellermann, K., Oster, H., Derer, S., Sina, C. Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine. ..
  18. Zhao L, Wang L, Di S, Xu Q, Ren Q, Chen S, et al. Steroidal alkaloid solanine A from Solanum nigrum Linn. exhibits anti-inflammatory activity in lipopolysaccharide/interferon γ-activated murine macrophages and animal models of inflammation. Biomed Pharmacother. 2018;105:606-615 pubmed publisher
  19. Pham T, Perez White B, Zhao H, Mortazavi F, Tonetti D. Protein kinase C α enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin. BMC Cancer. 2017;17:832 pubmed publisher
  20. Beke L, Kig C, Linders J, Boens S, Boeckx A, Van Heerde E, et al. MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. Biosci Rep. 2015;35: pubmed publisher
    ..Thus, targeting MELK by the inhibition of both its catalytic activity and its protein stability might sensitize tumours to DNA-damaging agents or radiation therapy by lowering the DNA-damage threshold. ..
  21. Cansby E, Magnusson E, Nuñez Durán E, Amrutkar M, Pedrelli M, Parini P, et al. STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2018;: pubmed publisher
  22. Rotllant G, Nguyen T, Sbragaglia V, Rahi L, Dudley K, Hurwood D, et al. Sex and tissue specific gene expression patterns identified following de novo transcriptomic analysis of the Norway lobster, Nephrops norvegicus. BMC Genomics. 2017;18:622 pubmed publisher
    ..The N. norvegicus data provide a foundation for future gene-based reproductive studies. ..
  23. Chen H, Wang Q, Yin Y, Li S, Niu D, Wang H. Genotypic variations between wild-type and small colony variant of Staphylococcus aureus in prosthetic valve infectious endocarditis: a comparative genomic and transcriptomic analysis. Int J Antimicrob Agents. 2018;51:655-658 pubmed publisher
    ..aureus. In conclusion, the reduced growth rate and decreased virulence of MRSA SCV strains may be related to mutations in and downregulation of genes associated with metabolism and virulence, especially plsY, deoC, eap and sstD. ..
  24. Zhang W, Ding Y, Zhang C, Lu Q, Liu Z, Coughlan K, et al. Deletion of endothelial cell-specific liver kinase B1 increases angiogenesis and tumor growth via vascular endothelial growth factor. Oncogene. 2017;36:4277-4287 pubmed publisher
    ..Endothelial LKB1 may regulate endothelial angiogenesis and tumor growth by modulating Sp1-mediated VEGF expression. ..
  25. Kuo J, Shih T, Lin J, Lai K, Lin M, Yang M, et al. Cantharidin induces DNA damage and inhibits DNA repair-associated protein expressions in TSGH8301 human bladder cancer cell. Anticancer Res. 2015;35:795-804 pubmed
    ..In conclusion, we found that cantharidin-induced cell death may occur through the induction of DNA damage and suppression of DNA repair-associated protein expression in TSGH8301 cells. ..
  26. Chursa U, Nuñez Durán E, Cansby E, Amrutkar M, Sütt S, Ståhlman M, et al. Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle. Diabetologia. 2017;60:553-567 pubmed publisher
    ..STK25 emerges as a new regulator of the complex interplay between lipid storage, mitochondrial energetics and insulin action in skeletal muscle, highlighting the potential of STK25 antagonists for type 2 diabetes treatment. ..
  27. Tse A, Li J, Chan T, Wu R, Lai K. Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma. Aquat Toxicol. 2015;165:189-96 pubmed publisher
    ..This study provides new insights on how hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells in fish, which is fundamentally important in environmental sciences and reproductive biology. ..
  28. Kong X, Kuilman T, Shahrabi A, Boshuizen J, Kemper K, Song J, et al. Cancer drug addiction is relayed by an ERK2-dependent phenotype switch. Nature. 2017;550:270-274 pubmed publisher
    ..Our results uncover a pathway that underpins drug addiction in cancer cells, which may help to guide the use of alternating therapeutic strategies for enhanced clinical responses in drug-resistant cancers...
  29. Zhao J, Liu N, Hao X, Que L, Liu J, Tang X. Association between integrin-linked kinase and hyperthermia in oral squamous cell carcinoma. Oncol Lett. 2017;14:7705-7714 pubmed publisher
    ..Therefore, ILK silencing combined with hypothermia may serve as a novel combination therapy strategy against OSCC...
  30. Rotllan N, Chamorro Jorganes A, Araldi E, Wanschel A, Aryal B, Aranda J, et al. Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis. FASEB J. 2015;29:597-610 pubmed publisher
    ..Together, these results provide evidence that macrophage Akt2 regulates migration, the inflammatory response and cholesterol metabolism and suggest that targeting Akt2 in macrophages might be beneficial for treating atherosclerosis. ..
  31. Behnia S, Fathizadeh S. Modeling the electrical conduction in DNA nanowires: charge transfer and lattice fluctuation theories. Phys Rev E Stat Nonlin Soft Matter Phys. 2015;91:022719 pubmed
    ..diagram reveals regions with a (quasi-)Ohmic property and other regions with negative differential resistance (NDR). NDR is a phenomenon that has been observed experimentally in DNA at room temperature...
  32. Mesubi O, Anderson M. Atrial remodelling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal. Cardiovasc Res. 2016;109:542-57 pubmed publisher
    ..This review considers current concepts and evidence from animal and human studies on the role of CaMKII in AF. ..
  33. Zhang B, Ma L, Wei J, Hu J, Zhao Z, Wang Y, et al. miR-137 Suppresses the Phosphorylation of AKT and Improves the Dexamethasone Sensitivity in Multiple Myeloma Cells Via Targeting MITF. Curr Cancer Drug Targets. 2016;16:807-817 pubmed
    ..We conclude that MITF is a direct target of miR-137. The miR-137 can improve the dexamethasone sensitivity in multiple myeloma cells by reducing the c-MET expression and further decreasing the AKT phosphorylation via targeting MITF. ..
  34. Wang S, Shi X, Li H, Pang P, Pei L, Shen H, et al. DAPK1 Signaling Pathways in Stroke: from Mechanisms to Therapies. Mol Neurobiol. 2017;54:4716-4722 pubmed publisher
    ..We hope to provide exhaustive summaries of relevant studies on DAPK1 signals involved in stroke damage. Therefore, disrupting DAPK1-relevant cell death pathway could be considered as a promising therapeutic approach in stroke. ..
  35. Chen S, Liu Y, Wang X, Wang H, Li S, Shi H, et al. Asparagine improves intestinal integrity, inhibits TLR4 and NOD signaling, and differently regulates p38 and ERK1/2 signaling in weanling piglets after LPS challenge. Innate Immun. 2016;22:577-587 pubmed publisher
  36. Chakraborty A, Prasanth S. Phosphorylation-dephosphorylation cycle of HP1? governs accurate mitotic progression. Cell Cycle. 2014;13:1663-70 pubmed publisher
    ..In the absence of the hinge-specific HP1? phosphorylation, either as a consequence of depleting NDR1 or in cells expressing a non-phosphorylatable HP1? mutant, the cells arrest in prometaphase with several mitotic ..
  37. Du Y, Ge M, Xue W, Yang Q, Wang S, Xu Y, et al. Chronic Lead Exposure and Mixed Factors of Gender×Age×Brain Regions Interactions on Dendrite Growth, Spine Maturity and NDR Kinase. PLoS ONE. 2015;10:e0138112 pubmed publisher
    b>NDR1/2 kinase is essential in dendrite morphology and spine formation, which is regulated by cellular Ca2+...
  38. Li K, Gao P, Xiang P, Zhang X, Cui X, Ma L. Molecular mechanisms of PFOA-induced toxicity in animals and humans: Implications for health risks. Environ Int. 2017;99:43-54 pubmed publisher
    ..Both in vivo and in vitro studies are needed to better understand the PFOA-induced toxicity mechanisms as well as the associated health risk in humans. ..
  39. Kurischko C, Broach J. Phosphorylation and nuclear transit modulate the balance between normal function and terminal aggregation of the yeast RNA-binding protein Ssd1. Mol Biol Cell. 2017;28:3057-3069 pubmed publisher
    ..of Ssd1 either with IPOD sites or with PB/SG requires the PLD, whose activity is differentially regulated by the Ndr/LATS family kinase, Cbk1: phosphorylation suppresses PB/SG association but enhances IPOD formation...
  40. Rotow J, Bivona T. Understanding and targeting resistance mechanisms in NSCLC. Nat Rev Cancer. 2017;17:637-658 pubmed publisher
    ..Finally, we discuss how understanding these themes can inform therapeutic strategies, including combination therapy approaches, and overcome the challenge of tumour heterogeneity...
  41. Rubenstein M, Hollowell C, Guinan P. Suppression of BCL2 by Antisense Oligonucleotides and Compensation by Non-Targeted Genes May Enhance Tumor Proliferation. In Vivo. 2015;29:687-93 pubmed
    ..This could be accomplished by dual monospecific targeting KI-67 and BCL2, or with a bispecific (or proposed multispecific) oligonucleotide simultaneously targeting both. ..
  42. Fayaz S, Rajanikant G. Ensembling and filtering: an effective and rapid in silico multitarget drug-design strategy to identify RIPK1 and RIPK3 inhibitors. J Mol Model. 2015;21:314 pubmed publisher
    ..Graphical Abstract A generalized workflow employed in this study. Subsequent utilization of EPS and PEPSF might lead to reduced computational time and load. ..
  43. Materne P, Vazquez E, Sanchez M, Yague Sanz C, Anandhakumar J, Migeot V, et al. Histone H2B ubiquitylation represses gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus. elife. 2016;5: pubmed publisher
    ..Upon induction, this process is reversed and efficient NDR (nucleosome depleted region) formation leads to high expression...
  44. Ichikawa Y, Morohashi N, Tomita N, Mitchell A, Kurumizaka H, Shimizu M. Sequence-directed nucleosome-depletion is sufficient to activate transcription from a yeast core promoter in vivo. Biochem Biophys Res Commun. 2016;476:57-62 pubmed publisher
    ..However, it remains unclear whether NDR formation per se is essential for transcriptional activation...
  45. Stamsås G, Straume D, Salehian Z, Havarstein L. Evidence that pneumococcal WalK is regulated by StkP through protein-protein interaction. Microbiology. 2017;163:383-399 pubmed publisher
    ..Our data strongly support the latter, i.e. that the transmembrane segment senses signals that regulate the activity of WalK. ..
  46. Appunni S, Rajisha P, Rubens M, Chandana S, Singh H, Swarup V. Targeting PknB, an eukaryotic-like serine/threonine protein kinase of Mycobacterium tuberculosis with phytomolecules. Comput Biol Chem. 2017;67:200-204 pubmed publisher
    ..These in silico analysis indicate that phytomolecules are capable to target PknB protein efficiently which is vital for mycobacterial survival and therefore can be excellent alternatives to conventional anti-tuberculosis drugs. ..
  47. Ben Sahra I, Manning B. mTORC1 signaling and the metabolic control of cell growth. Curr Opin Cell Biol. 2017;45:72-82 pubmed publisher
  48. Liao Y, Feng Y, Shen J, Gao Y, Cote G, Choy E, et al. Clinical and biological significance of PIM1 kinase in osteosarcoma. J Orthop Res. 2016;34:1185-94 pubmed publisher
    ..2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1185-1194, 2016. ..
  49. Wang J, Feng D, Li Z, Feng B, Zhang H, Zhang T, et al. Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in Rat. Neural Plast. 2015;2015:394820 pubmed publisher
    ..In conclusion, our data provide strong evidence for the role of mTOR in the RVM in nerve injury-induced neuropathic pain, indicating a novel mechanism of mTOR inhibitor-induced analgesia. ..
  50. Hero C, Rawshani A, Svensson A, Franzen S, Eliasson B, Eeg Olofsson K, et al. Association Between Use of Lipid-Lowering Therapy and Cardiovascular Diseases and Death in Individuals With Type 1 Diabetes. Diabetes Care. 2016;39:996-1003 pubmed publisher
    ..We used the Swedish National Diabetes Register (NDR) to perform a propensity score-based study...
  51. Ma C, Lin W, Liu Z, Tang W, Gautam R, Li H, et al. NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3. EMBO Rep. 2017;18:586-602 pubmed publisher
    ..Here, we report that nuclear Dbf2-related kinase 1 (NDR1) functions as a positive regulator of IL-17 signal transduction and IL-17-induced inflammation...
  52. Zhao C, Ma X, Guo H, Li P, Liu H. RIP2 deficiency attenuates cardiac hypertrophy, inflammation and fibrosis in pressure overload induced mice. Biochem Biophys Res Commun. 2017;493:1151-1158 pubmed publisher
    ..Taken together, our data indicated that RIP2-deficience ameliorated cardiac hypertrophy, inflammation and fibrosis through modulating multiple signaling pathways. ..
  53. Rolf Pissarczyk S, Yan S, Malavolti L, Burgess J, McMurtrie G, Loth S. Dynamical Negative Differential Resistance in Antiferromagnetically Coupled Few-Atom Spin Chains. Phys Rev Lett. 2017;119:217201 pubmed publisher
    We present the appearance of negative differential resistance (NDR) in spin-dependent electron transport through a few-atom spin chain...
  54. Cheng Y, Zhu Y, Xu J, Yang M, Chen P, Xu W, et al. PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway. Mol Cancer. 2018;17:13 pubmed publisher
    ..The expression of PKN2 in colon cancer cells suppresses tumor associated M2 macrophage polarization and tumor growth. Targeting PKN2 signaling pathway may provide a potential therapeutic strategy for colon cancer. ..
  55. Liu Z, Hettihewa M, Shu Y, Zhou C, Wan Q, Liu L. The mechanism of the adsorption of dsDNA on citrate-stabilized gold nanoparticles and a colorimetric and visual method for detecting the V600E point mutation of the BRAF gene. Mikrochim Acta. 2018;185:240 pubmed publisher
    ..Graphical abstract Schematic of the salt-induced aggregation of uncapped gold nanoparticles (AuNPs) which leads to a color change from red to blue. If the AuNPs are coated with dsDNA, aggregation is suppressed. ..
  56. Xiao K, McClatchy D, Shukla A, Zhao Y, Chen M, Shenoy S, et al. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A. 2007;104:12011-6 pubmed
    ..This study provides a comprehensive analysis of proteins that bind beta-arrestin isoforms and underscores their potentially broad regulatory roles in mammalian cellular physiology. ..
  57. Lee S, Han B, Cho J, Choi J, Lee J, Song H, et al. Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode. PLoS ONE. 2013;8:e70358 pubmed publisher
    ..The binding mode analysis suggests that the SKI-O-068 inhibitor can be improved by introducing functional groups that facilitate direct interaction with Lys67, which aid in the design of an optimized inhibitor. ..
  58. Liu X, Thungrat K, Boothe D. Multilocus Sequence Typing and Virulence Profiles in Uropathogenic Escherichia coli Isolated from Cats in the United States. PLoS ONE. 2015;10:e0143335 pubmed publisher
    ..eight non-multidrug resistant (SDR) isolates, and ST83 were significantly more likely to exhibit no drug resistant (NDR) isolates carrying the highest number of virulence genes...
  59. Mayer S, Baechler S, Damet J, Elmiger R, Frei D, Giannini S, et al. OCCUPATIONAL EXPOSURE TO EXTERNAL RADIATION IN SWITZERLAND. Radiat Prot Dosimetry. 2016;170:433-6 pubmed publisher
    ..exposure to external radiation of workers based on the data collected in the Swiss national dose registry (NDR) in 2013...
  60. Kakade V, Tao S, Rajagopal M, Zhou X, Li X, Yu A, et al. A cAMP and CREB-mediated feed-forward mechanism regulates GSK3β in polycystic kidney disease. J Mol Cell Biol. 2016;8:464-476 pubmed
  61. Yemets A, Fedorchuk V, Blume Y. [ENHANCEMENT OF AGROBACTERIAL TRANSFORMATION OF PLANTS USING PROTEIN KINASE INHIBITORS TRIFLUOPERAZINE AND GENISTEIN]. Tsitol Genet. 2016;50:3-11 pubmed
    ..It was found 100 ?M genistein provoked the increase of the frequency of agrobacterial transformation of tobacco leaf disks on 12%. ..
  62. DeSantiago J, Bare D, Ke Y, Sheehan K, Solaro R, Banach K. Functional integrity of the T-tubular system in cardiomyocytes depends on p21-activated kinase 1. J Mol Cell Cardiol. 2013;60:121-8 pubmed publisher
  63. Yan J, Huang W, Zhao J, Fu H, Zhang G, Huang X, et al. The platelet-derived growth factor receptor/STAT3 signaling pathway regulates the phenotypic transition of corpus cavernosum smooth muscle in rats. PLoS ONE. 2017;12:e0172191 pubmed publisher
    ..Through activation of the PDGFR/STAT3 signaling pathway, PDGF promoted the synthetic phenotype transition; thus, regulation of this pathway might contribute to ED therapy. ..
  64. Rossbach D, Bryan D, Hesselberth J, Sclafani R. Localization of Cdc7 Protein Kinase During DNA Replication in Saccharomyces cerevisiae. G3 (Bethesda). 2017;7:3757-3774 pubmed publisher
  65. Eftestøl E, Egner I, Lunde I, Ellefsen S, Andersen T, Sjåland C, et al. Increased hypertrophic response with increased mechanical load in skeletal muscles receiving identical activity patterns. Am J Physiol Cell Physiol. 2016;311:C616-C629 pubmed publisher
    ..The transmembrane molecule syndecan-4 implied in overload hypertrophy in cardiac muscle was not load dependent, suggesting that mechanosignaling in skeletal muscle is different. ..
  66. Otero G, Pechlaner G, Liberman G, Gürcan E. The neoliberal diet and inequality in the United States. Soc Sci Med. 2015;142:47-55 pubmed publisher
    ..We then introduce our Neoliberal Diet Risk Index (NDR), comprised of measures of food-import dependency, the Gini coefficient, rates of urbanization, female labor-force ..
  67. Imamura S, Kawase Y, Kobayashi I, Sone T, Era A, Miyagishima S, et al. Target of rapamycin (TOR) plays a critical role in triacylglycerol accumulation in microalgae. Plant Mol Biol. 2015;89:309-18 pubmed publisher
    ..These results suggest the general involvement of TOR signaling in TAG accumulation in divergent microalgae. ..
  68. Fu G, Sivaprakasam P, Dale O, Manly S, Cutler S, Doerksen R. Pharmacophore Modeling, Ensemble Docking, Virtual Screening, and Biological Evaluation on Glycogen Synthase Kinase-3?. Mol Inform. 2014;33:610-26 pubmed publisher
    ..The bioassay results showed that 15 out of the 24 hit compounds are indeed GSK-3? inhibitors, and among them, one compound exhibiting sub-micromolar inhibitory activity is a reasonable starting point for further optimization. ..
  69. Abe S, Nagai T, Masukawa M, Okumoto K, Homma Y, Fujiki Y, et al. Localization of Protein Kinase NDR2 to Peroxisomes and Its Role in Ciliogenesis. J Biol Chem. 2017;292:4089-4098 pubmed publisher
    Nuclear Dbf2-related (NDR) kinases, comprising NDR1 and NDR2, are serine/threonine kinases that play crucial roles in the control of cell proliferation, apoptosis, and morphogenesis...
  70. Bieri R, Scherr N, Ruf M, Dangy J, Gersbach P, Gehringer M, et al. The Macrolide Toxin Mycolactone Promotes Bim-Dependent Apoptosis in Buruli Ulcer through Inhibition of mTOR. ACS Chem Biol. 2017;12:1297-1307 pubmed publisher
    ..Our findings provide a new coherent and comprehensive concept of BU pathogenesis. ..
  71. Ishikawa S, Hayashi S, Abe T, Igura M, Kuramata M, Tanikawa H, et al. Low-cesium rice: mutation in OsSOS2 reduces radiocesium in rice grains. Sci Rep. 2017;7:2432 pubmed publisher
    ..Since the lcs1 plant had no significant negative effects on agronomic traits when grown in radiocesium-contaminated paddy fields, this mutant could be used directly in agriculture for reducing radiocesium in rice grains. ..
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