stearoyl CoA desaturase

Summary

Gene Symbol: stearoyl CoA desaturase
Description: stearoyl-CoA desaturase
Alias: FADS5, MSTP008, SCD1, SCDOS, hSCD1, acyl-CoA desaturase, delta(9)-desaturase, fatty acid desaturase, stearoyl-CoA desaturase (delta-9-desaturase), stearoyl-CoA desaturase opposite strand
Species: human
Products:     stearoyl CoA desaturase

Top Publications

  1. Attie A, Krauss R, Gray Keller M, Brownlie A, Miyazaki M, Kastelein J, et al. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J Lipid Res. 2002;43:1899-907 pubmed
    ..Mice with a targeted disruption of the SCD1 gene have very low levels of VLDL and impaired triglyceride and cholesterol ester biosynthesis...
  2. Du X, Wang Q, Chan E, Merchant M, Liu J, French D, et al. FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth. Cancer Res. 2012;72:5843-55 pubmed publisher
    ..In turn, SREBP1 regulates the expression of key lipogenic enzymes, including stearoyl CoA desaturase 1 (SCD1/SCD)...
  3. Zhang L, Ge L, Parimoo S, Stenn K, Prouty S. Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. Biochem J. 1999;340 ( Pt 1):255-64 pubmed
  4. Shiwaku K, Hashimoto M, Kitajima K, Nogi A, Anuurad E, Enkhmaa B, et al. Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians. J Lipid Res. 2004;45:914-22 pubmed
    ..HTG is ethnicity-specifically associated with an increase in the 18:1/18:0 ratio and a decrease in n-3 PUFA in plasma for Japanese, Koreans, and Mongolians. ..
  5. Moore S, Knudsen B, True L, Hawley S, Etzioni R, Wade C, et al. Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma. Int J Cancer. 2005;114:563-71 pubmed
    ..These results indicate that loss of SCD expression is a frequent event in prostate adenocarcinoma, and further supports a role for altered lipid metabolism as a factor in the process of carcinogenesis. ..
  6. Scaglia N, Caviglia J, Igal R. High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts. Biochim Biophys Acta. 2005;1687:141-51 pubmed
    ..The strong correlation of high levels of MUFA and neoplastic phenotype suggest that the regulation of stearoyl CoA desaturase (SCD) must play a significant role in cancer development...
  7. Gong J, Campos H, McGarvey S, Wu Z, Goldberg R, Baylin A. Genetic variation in stearoyl-CoA desaturase 1 is associated with metabolic syndrome prevalence in Costa Rican adults. J Nutr. 2011;141:2211-8 pubmed publisher
    Stearoyl-CoA desaturase 1 (SCD1) activity, a key regulator of lipid metabolism, may be associated with the development of metabolic syndrome (MetS)...
  8. Scaglia N, Chisholm J, Igal R. Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK. PLoS ONE. 2009;4:e6812 pubmed publisher
    ..We have previously shown that a stable knockdown of stearoyl-CoA desaturase 1 (SCD1), the main Delta9-desaturase that converts SFA into MUFA, in cancer cells decreases the rate of lipogenesis, ..
  9. Holder A, Gonzalez Angulo A, Chen H, Akcakanat A, Do K, Fraser Symmans W, et al. High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients. Breast Cancer Res Treat. 2013;137:319-27 pubmed publisher
    Stearoyl-CoA desaturase 1 (SCD1) is an essential regulator of fatty acid synthesis. We have previously shown that overexpression of SCD1 increases the growth of breast cancer cell lines...

More Information

Publications99

  1. Mauvoisin D, Charfi C, Lounis A, Rassart E, Mounier C. Decreasing stearoyl-CoA desaturase-1 expression inhibits ?-catenin signaling in breast cancer cells. Cancer Sci. 2013;104:36-42 pubmed publisher
    Stearoyl-CoA desaturase-1 (SCD1) is an endoplasmic reticulum anchored enzyme catalyzing the synthesis of monounsaturated fatty acids, mainly palmytoleyl-CoA and oleyl-CoA...
  2. Mason P, Liang B, Li L, Fremgen T, Murphy E, Quinn A, et al. SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. PLoS ONE. 2012;7:e33823 pubmed publisher
    ..Using RNAi we have demonstrated that depletion of fatty-acid synthesis pathway enzymes SCD1, FASN, or ACC1 in HCT116 colon cancer cells results in cytotoxicity that is reversible by addition of exogenous ..
  3. Mauvoisin D, Mounier C. Hormonal and nutritional regulation of SCD1 gene expression. Biochimie. 2011;93:78-86 pubmed publisher
    Stearoyl-CoA Desaturase 1 (SCD1) is the rate limiting enzyme catalyzing the biosynthesis of monounsaturated fatty acids preferentially from palmitoyl-CoA and stearoyl-CoA forming respectively palmitoleyl-CoA and oleyl-CoA...
  4. Scaglia N, Igal R. Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis. Int J Oncol. 2008;33:839-50 pubmed
    ..of tissue MUFA and several types of cancer has been reported, but a causal relationship between the function of SCD1, the main human SCD isoform, and cancer development has not yet been firmly established...
  5. Li J, Ding S, Habib N, Fermor B, Wood C, Gilmour R. Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues. Int J Cancer. 1994;57:348-52 pubmed
    ..It is suggested that certain classes of tumour may exhibit increased levels of desaturase mRNA. ..
  6. Hulver M, Berggren J, Carper M, Miyazaki M, Ntambi J, Hoffman E, et al. Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab. 2005;2:251-61 pubmed
    ..Herein, we show that the lipogenic gene, stearoyl-CoA desaturase 1 (SCD1), is robustly up-regulated in skeletal muscle from extremely obese humans...
  7. Stefan N, Peter A, Cegan A, Staiger H, Machann J, Schick F, et al. Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans. Diabetologia. 2008;51:648-56 pubmed publisher
    Stearoyl-CoA desaturase 1 (SCD1) is the rate-limiting enzyme in monounsaturated fatty acid synthesis. It is imperative for the assembly of VLDL particles, which transport triacylglycerol (TG) from liver to adipose tissue and other sites...
  8. Kotronen A, Seppanen Laakso T, Westerbacka J, Kiviluoto T, Arola J, Ruskeepää A, et al. Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver. Diabetes. 2009;58:203-8 pubmed publisher
    To determine whether 1) hepatic ceramide and diacylglycerol concentrations, 2) SCD1 activity, and 3) hepatic lipogenic index are increased in the human nonalcoholic fatty liver...
  9. Zhou Y, Egeland G, Meltzer S, Kubow S. The association of desaturase 9 and plasma fatty acid composition with insulin resistance-associated factors in female adolescents. Metabolism. 2009;58:158-66 pubmed publisher
  10. Scaglia N, Igal R. Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells. J Biol Chem. 2005;280:25339-49 pubmed
  11. Minville Walz M, Pierre A, Pichon L, Bellenger S, Fèvre C, Bellenger J, et al. Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells. PLoS ONE. 2010;5:e14363 pubmed publisher
    ..This change in fatty acid metabolism is associated with overexpression of stearoyl-CoA desaturase 1 (Scd1), which catalyses the transformation of saturated fatty acids into monounsaturated fatty acids (e.g., oleic acid)...
  12. Peter A, Cegan A, Wagner S, Elcnerova M, Konigsrainer A, Königsrainer I, et al. Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans. Am J Physiol Endocrinol Metab. 2011;300:E321-6 pubmed publisher
    Stearoyl-CoA desaturase-1 (SCD1) has gained much interest as a future drug target to treat fatty liver and its consequences. However, there are few and inconsistent human data about expression and activity of this important enzyme...
  13. Ide Y, Waki M, Hayasaka T, Nishio T, Morita Y, Tanaka H, et al. Human breast cancer tissues contain abundant phosphatidylcholine(36?1) with high stearoyl-CoA desaturase-1 expression. PLoS ONE. 2013;8:e61204 pubmed publisher
    ..The protein expression of stearoyl-CoA desaturase-1 (SCD1), which is a synthetic enzyme of MUFA, showed accumulation in the cancerous areas as observed by the results of ..
  14. Liew C, Groves C, Wiltshire S, Zeggini E, Frayling T, Owen K, et al. Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism. Diabetologia. 2004;47:2168-75 pubmed
    ..Although this study provided no evidence that SCD sequence variation influences diabetes susceptibility or related traits, SCD remains a major target for pharmaceutical and/or environmental manipulation. ..
  15. von Roemeling C, Marlow L, Wei J, Cooper S, Caulfield T, Wu K, et al. Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Clin Cancer Res. 2013;19:2368-80 pubmed publisher
    We set out to identify Stearoyl-CoA desaturase 1 (SCD1) as a novel molecular target in clear cell renal cell carcinoma (ccRCC) and examine its role in tumor cell growth and viability in vitro and in vivo independently as well as in ..
  16. Warensjo E, Ingelsson E, Lundmark P, Lannfelt L, Syvanen A, Vessby B, et al. Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity. Obesity (Silver Spring). 2007;15:1732-40 pubmed
    ..The lipogenic enzyme, stearoyl-coenzyme A-desaturase (SCD), is related to obesity. Further, SCD1-deficent mice are protected against obesity and insulin resistance...
  17. Wang J, Yu L, Schmidt R, Su C, Huang X, Gould K, et al. Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Biochem Biophys Res Commun. 2005;332:735-42 pubmed
    ..Microsome fractions prepared from hSCD1 and hSCD5 transfected cells displayed similar delta 9 desaturase activity...
  18. McNamara R, Liu Y, Jandacek R, Rider T, Tso P. The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity. Prostaglandins Leukot Essent Fatty Acids. 2008;78:293-304 pubmed publisher
    ..The implications of age-related reductions in OFC PUFA composition for affective dysregulation in the elderly are discussed. ..
  19. Mar Heyming R, Miyazaki M, Weissglas Volkov D, Kolaitis N, Sadaat N, Plaisier C, et al. Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol. 2008;28:1193-9 pubmed publisher
    Stearoyl-CoA desaturase 1 (SCD1) is the rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, and in mice SCD1 activity is associated with plasma triglyceride levels...
  20. Tian J, Lu R, Ji H, Sun J, Li C, Liu P, et al. Comparative analysis of the hepatopancreas transcriptome of grass carp (Ctenopharyngodon idellus) fed with lard oil and fish oil diets. Gene. 2015;565:192-200 pubmed publisher
    ..These findings presented here provide a comprehensive understanding of the molecular mechanisms governing the effects of fish oil in grass carp. ..
  21. Wu N, Li R, Li L. SOAT1 deficiency attenuates atherosclerosis by regulating inflammation and cholesterol transportation via HO-1 pathway. Biochem Biophys Res Commun. 2018;501:343-350 pubmed publisher
    ..In addition, expression levels of fatty acid synthase (FAS), stearoyl-CoA desaturase 1 (SCD1), protein convertase subtilisin/kexin type 9 (PCSK 9) and sterol regulatory element-binding protein-1c (SREBP-1c) ..
  22. Kim J, Kang E, Park M, Kim J, Kim S, Jeung E, et al. The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins. Environ Toxicol Pharmacol. 2015;40:284-91 pubmed publisher
    ..The altered fat metabolism by OP may affect the nutrition balance during pregnancy and can cause metabolism-related diseases. ..
  23. Poloni S, Spritzer P, Mendes R, D Almeida V, Castro K, Sperb Ludwig F, et al. Leptin concentrations and SCD-1 indices in classical homocystinuria: Evidence for the role of sulfur amino acids in the regulation of lipid metabolism. Clin Chim Acta. 2017;473:82-88 pubmed publisher
    ..829; p=0.04) in HCU patients. We report alterations in leptin and SCD-1 in HCU patients. These results agree with previous findings from epidemiologic and animal studies, and support a role for SAA on lipid homeostasis. ..
  24. Mziaut H, Korza G, Ozols J. The N terminus of microsomal delta 9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation. Proc Natl Acad Sci U S A. 2000;97:8883-8 pubmed
    ..These results demonstrate that the N-terminal segment of some 30 residues of SCD constitutes a motif responsible for the rapid degradation of SCD. ..
  25. Zhou B, Zhou D, Wei X, Zhong R, Xu J, Sun L. Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation. Acta Pharmacol Sin. 2017;38:998-1008 pubmed publisher
    ..of mature SREBP-1 and subsequently decreased the mRNA levels of lipogenic genes including acc1, fas and scd1. AS-IV treatment also concentration-dependently attenuated FFA-induced hepatic ER stress evidenced by the reduction ..
  26. Nouraie M, Gordeuk V. Blood transfusion and 30-day readmission rate in adult patients hospitalized with sickle cell disease crisis. Transfusion. 2015;55:2331-8 pubmed publisher
    ..There is a need for a prospective study to examine the potential benefit and safety of simple blood transfusion for this purpose. ..
  27. Gouw A, Alsema A, Tijms B, Borta A, Scheltens P, Stam C, et al. EEG spectral analysis as a putative early prognostic biomarker in nondemented, amyloid positive subjects. Neurobiol Aging. 2017;57:133-142 pubmed publisher
    ..5 [0.3-1.0] resp. 0.6 [0.4-1.0]) were associated with clinical progression over time. In amyloid positive subjects with normal cognition, slowing of oscillatory brain activity is related to clinical progression. ..
  28. Grześk G, Stolarek W, Kasprzak M, Krzyżanowski M, Szadujkis Szadurska K, Wiciński M, et al. Therapeutic drug monitoring of digoxin-20 years of experience. Pharmacol Rep. 2018;70:184-189 pubmed publisher
    ..It was confirmed that an elevated digoxin level occurs in the course of treatment in the case of women. ..
  29. ALJohani A, Syed D, Ntambi J. Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism. Trends Endocrinol Metab. 2017;28:831-842 pubmed publisher
    Stearoyl-coenzyme A desaturase 1 (SCD1) is a central regulator of fuel metabolism and may represent a therapeutic target to control obesity and the progression of related metabolic diseases including type 2 diabetes and hepatic steatosis...
  30. de Oliveira Antunes M, Samesima N, Pereira Filho H, Matsumoto A, Verrier R, Pastore C, et al. Exercise-induced quantitative microvolt T-wave alternans in hypertrophic cardiomyopathy. J Electrocardiol. 2017;50:184-190 pubmed publisher
    ..001), family history of SCD (p=0.006), septal thickness ?30mm (p<0.001); and inadequate blood pressure response to effort (p=0.04). ..
  31. Antu K, Riya M, Nair A, Mishra A, Srivastava A, Raghu K. Symplocos cochinchinensis enhances insulin sensitivity via the down regulation of lipogenesis and insulin resistance in high energy diet rat model. J Ethnopharmacol. 2016;193:500-509 pubmed publisher
    ..the normal physiology of animals via proteins and genes relevant to metabolism like stearoyl-CoA desaturase (SCD1), sterol regulatory element binding protein 1 (SREBP-1c), fatty acid synthase (FAS), glucose 6 phosphatase (G6Pase),..
  32. Kääb S. Genetics of sudden cardiac death - An epidemiologic perspective. Int J Cardiol. 2017;237:42-44 pubmed publisher
  33. Zhang X, Zhang W, Saraf S, Nouraie M, Han J, Gowhari M, et al. Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease. Hum Genet. 2015;134:895-904 pubmed publisher
    ..Our study reveals a novel, environment-specific genetic polymorphism that may affect key metabolic pathways contributing to diabetes in SCD. ..
  34. Yang K, Kyle J, Makielski J, Dudley S. Mechanisms of sudden cardiac death: oxidants and metabolism. Circ Res. 2015;116:1937-55 pubmed publisher
  35. Carroll C, Lanzkron S, Haywood C, Kiley K, Pejsa M, Moscou Jackson G, et al. Chronic Opioid Therapy and Central Sensitization in Sickle Cell Disease. Am J Prev Med. 2016;51:S69-77 pubmed publisher
    ..Overall, the results point out a high symptom burden in SCD patients on COT, including those on high-dose COT, and suggest that nociceptive processing in SCD patients on COT differs from those who are not. ..
  36. Papapetrou E. Gene and Cell Therapy for β-Thalassemia and Sickle Cell Disease with Induced Pluripotent Stem Cells (iPSCs): The Next Frontier. Adv Exp Med Biol. 2017;1013:219-240 pubmed publisher
    ..Here we discuss the theoretical advantages of cell therapies utilizing hPSC derivatives, recent proof-of-principle studies and the main challenges towards realizing the potential of hPSC therapies in the clinic. ..
  37. Yang Q, Wang P, Cui J, Wang W, Chen Y, Zhang T. Panax notoginseng saponins attenuate lung cancer growth in part through modulating the level of Met/miR-222 axis. J Ethnopharmacol. 2016;193:255-265 pubmed publisher
    ..The expression of an array of genes promoting tumorigenesis and progression including Hgf, Met, Notch3, Scd1, Epas1, Col1a1, Raf1, Braf1 and CDK6 was significantly decreased by PNS treatment, whereas the expression of tumor ..
  38. Michiue T, Sogawa N, Ishikawa T, Maeda H. Cardiac dilatation index as an indicator of terminal central congestion evaluated using postmortem CT and forensic autopsy data. Forensic Sci Int. 2016;263:152-157 pubmed publisher
  39. Arumugam P, Mullins E, Shanmukhappa S, Monia B, Loberg A, Shaw M, et al. Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice. Blood. 2015;126:1844-55 pubmed publisher
    ..Taken together, these data establish that prothrombin is a powerful modifier of SCD-induced end-organ damage, and present a novel therapeutic target to ameliorate SCD pathologies. ..
  40. Ijiro T, Nakamura K, Ogata M, Inada H, Kiguchi S, Maruyama K, et al. Effect of rovatirelin, a novel thyrotropin-releasing hormone analog, on the central noradrenergic system. Eur J Pharmacol. 2015;761:413-22 pubmed publisher
    ..Thus, rovatirelin may have an orally effective therapeutic potential in patients with SCD. ..
  41. Yucha R, Hobbs K, Hanhauser E, Hogan L, Nieves W, Ozen M, et al. High-throughput Characterization of HIV-1 Reservoir Reactivation Using a Single-Cell-in-Droplet PCR Assay. EBioMedicine. 2017;20:217-229 pubmed publisher
    ..As a result, our assay has the potential to provide needed insight into various reservoir eradication strategies. ..
  42. Wang T, Feugang J, Crenshaw M, Regmi N, Blanton J, Liao S. A Systems Biology Approach Using Transcriptomic Data Reveals Genes and Pathways in Porcine Skeletal Muscle Affected by Dietary Lysine. Int J Mol Sci. 2017;18: pubmed publisher
    ..Collectively, dietary lysine may function as a signaling molecule to regulate protein turnover and lipid metabolism in the skeletal muscle of finishing pigs. ..
  43. Kato H, Sakaki K, Mihara K. Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase. J Cell Sci. 2006;119:2342-53 pubmed
    Mammalian Delta9 stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in the biosynthesis of mono-unsaturated fatty acids in the endoplasmic reticulum (ER)...
  44. Williams S, Browne Ferdinand B, Smart Y, Morella K, Reed S, Kanter J. Newborn Screening for Sickle Cell Disease in St. Vincent and the Grenadines: Results of a Pilot Newborn Screening Program. Glob Pediatr Health. 2017;4:2333794X17739191 pubmed publisher
    ..All 3 patients with SCD received treatment before 3 months of age. Conclusions: A newborn screening program is feasible in this population when partnered with an established newborn screening laboratory...
  45. Pahl D, Green N, Bhatia M, Lee M, Chang J, Licursi M, et al. Optical Coherence Tomography Angiography and Ultra-widefield Fluorescein Angiography for Early Detection of Adolescent Sickle Retinopathy. Am J Ophthalmol. 2017;183:91-98 pubmed publisher
    ..If these findings are confirmed with larger cross-sectional and prospective analyses, these approaches may enhance early screening for sickle retinopathy. ..
  46. Toral P, Frutos P, Carreño D, Hervás G. Endogenous synthesis of milk oleic acid in dairy ewes: In vivo measurement using 13C-labeled stearic acid. J Dairy Sci. 2017;100:5880-5887 pubmed publisher
    ..The proportion of oleic acid being synthesized endogenously was estimated to represent between 48 and 57% of the amount secreted in milk. Further research under different dietary conditions is recommended. ..
  47. Cheatham C, Lupu D, Niculescu M. Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance. Nutr Res. 2015;35:948-55 pubmed publisher
    ..abilities, as the level of fatty acids transferred across the placenta may be affected by the maternal fatty acid desaturase 2 (FADS2) rs174575 single nucleotide polymorphism...
  48. Dinshaw L, Münch J, Dickow J, Lezius S, Willems S, Hoffmann B, et al. The T-peak-to-T-end interval: a novel ECG marker for ventricular arrhythmia and appropriate ICD therapy in patients with hypertrophic cardiomyopathy. Clin Res Cardiol. 2018;107:130-137 pubmed publisher
    ..Our findings suggest that TpTe can possibly serve as a marker for ventricular arrhythmogenesis in pts. with HCM and assessment of TpTe might, therefore, optimize SCD risk stratification. ..
  49. Tsukahara A, Yoshida K, Matsushima A, Ajima K, Kuroda C, Mizukami N, et al. Evaluation of walking smoothness using wearable robotic system curara® for spinocerebellar degeneration patients. IEEE Int Conf Rehabil Robot. 2017;2017:1494-1499 pubmed publisher
    ..2% compared with unassisted walking, when the gain condition settings of hip and knee joints are set at 0.4 and 0.5, respectively. Consequently, these results verified the effectiveness of the curara system for patients with SCD. ..
  50. Xue Y, Zhao R, Du S, Zhao D, Li D, Xu J, et al. Decreased mRNA levels of cardiac Cx43 and ZO1 in sudden cardiac death related to coronary atherosclerosis: a pilot study. Int J Legal Med. 2016;130:915-22 pubmed publisher
    ..Analysis of cardiac Cx43 and ZO1 using real-time PCR is useful in diagnosis of SCD, and validation of reference genes is crucial. ..
  51. Ezenwa M, Molokie R, Wang Z, Yao Y, Suarez M, Dyal B, et al. Differences in Sensory Pain, Expectation, and Satisfaction Reported by Outpatients with Cancer or Sickle Cell Disease. Pain Manag Nurs. 2018;19:322-332 pubmed publisher
    ..49) groups. Outpatients with SCD reported three of four sensory pain parameters that were greater than those reported by outpatients with cancer. A better understanding of these differences is pertinent to improving pain outcomes. ..
  52. Carobbio S, Hagen R, Lelliott C, Slawik M, Medina Gomez G, Tan C, et al. Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity. Diabetes. 2013;62:3697-708 pubmed publisher
    ..These adaptive mechanisms contribute to maintain lipid desaturation through preferential SCD1 regulation and facilitate fat storage in WAT, despite on-going metabolic stress.
  53. Hellenthal N, Gaertner Rommel A, Klauke B, Paluszkiewicz L, Stuhr M, Kerner T, et al. Molecular autopsy of sudden unexplained deaths reveals genetic predispositions for cardiac diseases among young forensic cases. Europace. 2017;19:1881-1890 pubmed publisher
    ..Aim of this study was to determine the portion of underlying genetic heart diseases among unexplained putative SCD cases from a large German forensic department...
  54. Roke K, Jannas Vela S, Spriet L, Mutch D. FADS2 genotype influences whole-body resting fat oxidation in young adult men. Appl Physiol Nutr Metab. 2016;41:791-4 pubmed publisher
    Considerable evidence supports an association between fatty acid desaturase 2 (FADS2) polymorphisms and the efficiency of converting alpha-linolenic acid (ALA) into eicosapentaenoic acid (EPA) via the desaturation-elongation pathway...
  55. Zhang J, Cui L, Ma J, Chen C, Yang B, Huang L. Transcriptome analyses reveal genes and pathways associated with fatty acid composition traits in pigs. Anim Genet. 2017;48:645-652 pubmed publisher
  56. Gonsalves C, Li C, Malik P, Tahara S, Kalra V. Peroxisome proliferator-activated receptor-α-mediated transcription of miR-301a and miR-454 and their host gene SKA2 regulates endothelin-1 and PAI-1 expression in sickle cell disease. Biosci Rep. 2015;35: pubmed publisher
    ..Our studies provide a potential therapeutic approach whereby fenofibrate-induced miR-301a/miR-454 expression can ameliorate PH and lung fibrosis by reduction in ET-1 and PAI-1 levels in SCD. ..
  57. Siqingaowa -, Sekar S, Gopalakrishnan V, Taghibiglou C. Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation. Biochem Biophys Res Commun. 2017;488:136-140 pubmed publisher
    ..Our in vitro data suggest that SREBP1 may contribute to pancreatic tumor growth and its inhibitors could be considered as a potential target in the management of pancreatic cancer cell proliferation. ..
  58. Müller S, Preische O, Göpfert J, Yañez V, Joos T, Boecker H, et al. Tau plasma levels in subjective cognitive decline: Results from the DELCODE study. Sci Rep. 2017;7:9529 pubmed publisher
    ..In conclusion, plasma tau is not increased in SCD patients. In addition, the lack of correlation between tau in plasma and CSF in the examined cohort suggests that tau levels are affected by different factors in both biofluids. ..
  59. Noubiap J, Mengnjo M, Nicastro N, Kamtchum Tatuene J. Neurologic complications of sickle cell disease in Africa: A systematic review and meta-analysis. Neurology. 2017;89:1516-1524 pubmed publisher
  60. Khemani K, Ross D, Sinha C, Haight A, Bakshi N, Krishnamurti L. Experiences and Decision Making in Hematopoietic Stem Cell Transplant in Sickle Cell Disease: Patients' and Caregivers' Perspectives. Biol Blood Marrow Transplant. 2018;24:1041-1048 pubmed publisher
    ..Understanding the key influential factors in decision making and the impact HSCT has on these patients and their families will generate crucial insights that can guide the care of future patients and research studies. ..
  61. Jeyakumar S, Sheril A, Vajreswari A. Vitamin A Improves Hyperglycemia and Glucose-Intolerance through Regulation of Intracellular Signaling Pathways and Glycogen Synthesis in WNIN/GR-Ob Obese Rat Model. Prev Nutr Food Sci. 2017;22:172-183 pubmed publisher
    Vitamin A and its metabolites modulate insulin resistance and regulate stearoyl-CoA desaturase 1 (SCD1), which are also known to affect insulin resistance...
  62. Agarwal N, Iyer D, Gabbi C, Saha P, Patel S, Mo Q, et al. HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXR? and PPAR? dysregulation: implications for HIV-specific pathogenesis of NAFLD. Sci Rep. 2017;7:13362 pubmed publisher
    ..liver X receptor-? (LXR?) with increased expression of its lipogenic targets Srebp1c, Chrebp, Lpk, Dgat, Fasn and Scd1, and intranuclear SREBP1c and ChREBP...
  63. Nakaya K, Ayaori M, Uto Kondo H, Sotherden G, Nishida T, Katamoto H, et al. Overexpression of stearoyl-coenzyme A desaturase 1 in macrophages promotes reverse cholesterol transport. Biochim Biophys Acta. 2013;1831:1402-11 pubmed publisher
    Stearoyl-coenzyme A desaturase 1 (SCD1) is the rate-limiting enzyme in the synthesis of monounsaturated fatty acids. However, the impact of SCD1 on atherosclerosis remains unclear...
  64. Martin O, Moquist K, Hennessy J, Nelson S. Invasive pneumococcal disease in children with sickle cell disease in the pneumococcal conjugate vaccine era. Pediatr Blood Cancer. 2018;65: pubmed publisher
    ..Further study is needed to characterize the incidence of and risk factors for the development of IPD in SCD in the PCV era to help drive better prevention strategies...
  65. Puri L, Nottage K, Hankins J, Anghelescu D. State of the Art Management of Acute Vaso-occlusive Pain in Sickle Cell Disease. Paediatr Drugs. 2018;20:29-42 pubmed publisher
    ..This report reviews the mechanisms of pain associated with acute VOC, describes the current management of VOC, and describes some of the new therapies under evaluation for the management of acute VOC in SCD. ..
  66. Fontao F, Barnes L, Kaya G, Saurat J, Sorg O. High susceptibility of Lrig1 sebaceous stem cells to TCDD in mice. Toxicol Sci. 2017;: pubmed publisher
    ..within the glands, and (iii) a dramatic repression of the genes encoding the sebogenic enzymes AWAT1, ELOVL3 and SCD1. These effects were reversible...
  67. Winchenne A, Cecchini J, Deux J, de Prost N, Razazi K, Carteaux G, et al. A clinical risk score for pulmonary artery thrombosis during acute chest syndrome in adult patients with sickle cell disease. Br J Haematol. 2017;179:627-634 pubmed publisher
    ..The negative predictive value of a PAT-ACS risk score ≥2 was 94%. In conclusion, we propose a simple clinical risk score to identify SCD patients at high risk of PAT during ACS. ..
  68. Lee M, Shin Y, Jung S, Kim S, Jo Y, Kim C, et al. The Inhibitory Effect of Tartary Buckwheat Extracts on Adipogenesis and Inflammatory Response. Molecules. 2017;22: pubmed publisher
    ..These results suggest that TBEs may inhibit adipogenesis and inflammatory response; therefore, they seem to be beneficial as a food ingredient to prevent obesity-associated inflammation. ..
  69. Thomsen K, Laposata M, Njoroge S, Umunakwe O, Katrangi W, Seegmiller A. Increased elongase 6 and Δ9-desaturase activity are associated with n-7 and n-9 fatty acid changes in cystic fibrosis. Lipids. 2011;46:669-77 pubmed publisher
    ..Taken together, these findings suggest that fatty acid abnormalities of the n-7 and n-9 series in cystic fibrosis are as a result, at least in part, of increased expression and activity of these metabolic enzymes in CFTR-mutated cells. ..
  70. Shi H, Zhang C, Zhao W, Luo J, Loor J. Peroxisome proliferator-activated receptor delta facilitates lipid secretion and catabolism of fatty acids in dairy goat mammary epithelial cells. J Dairy Sci. 2017;100:797-806 pubmed publisher
    ..Collectively, these results highlight an important role for PPARD in the homeostasis of ruminant mammary cells by facilitating fatty acid activation and lipid droplet formation and secretion. ..
  71. Garcia C, Duby C, Catheline D, Toral P, Bernard L, Legrand P, et al. Synthesis of the suspected trans-11,cis-13 conjugated linoleic acid isomer in ruminant mammary tissue by FADS3-catalyzed ?13-desaturation of vaccenic acid. J Dairy Sci. 2017;100:783-796 pubmed publisher
    ..However, in rodents, the fatty acid desaturase 3 (FADS3) gene was recently shown to code for an enzyme able to catalyze the unexpected ?13-desaturation ..
  72. Nashed M, Chisholm J, Igal R. Stearoyl-CoA desaturase activity modulates the activation of epidermal growth factor receptor in human lung cancer cells. Exp Biol Med (Maywood). 2012;237:1007-17 pubmed
    Stearoyl-CoA desaturase-1 (SCD1), the main enzyme that converts saturated fatty acids into monounsaturated fatty acids, is a key factor in the mechanisms of cancer cell proliferation, survival and tumorigenesis...
  73. Ikaga R, Li D, Yamazaki T. Dietary ?-conglycinin prevents acute ethanol-induced fatty liver in mice. Biochem Biophys Res Commun. 2017;493:542-547 pubmed publisher
  74. Magnusson P, Morner S. EvaLuation Using Cardiac Insertable Devices And TelephonE in Hypertrophic Cardiomyopathy (ELUCIDATE HCM)-rationale and design: a prospective observational study on incidence of arrhythmias in Sweden. BMJ Open. 2017;7:e019541 pubmed publisher
    ..The remaining time the potential burden arrhythmia is unknown. Therefore, the aim of the present study is to assess NSVT and AF incidence during 18 months by an insertable cardiac monitor (ICM)...
  75. Zhang J, Song F, Zhao X, Jiang H, Wu X, Wang B, et al. EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer. Mol Cancer. 2017;16:127 pubmed publisher
    ..This is the focus of our study. The interaction between EGFR and stearoyl-CoA desaturase-1 (SCD1) was detected byco-immunoprecipitation...
  76. Wakefield E, Popp J, Dale L, Santanelli J, Pantaleao A, Zempsky W. Perceived Racial Bias and Health-Related Stigma Among Youth with Sickle Cell Disease. J Dev Behav Pediatr. 2017;38:129-134 pubmed publisher
    ..The purpose of this study was to investigate the occurrence of perceived racial bias and health-related stigma among youth with SCD and its relationship with psychological and physical well-being...
  77. Bacchi S, Chim I, Kramer P, Postuma R. Domperidone for Hypotension in Parkinson's Disease: A Systematic Review. J Parkinsons Dis. 2017;7:603-617 pubmed publisher
    ..However, domperidone use in PD is tempered by concerns regarding QT prolongation and ventricular tachyarrhythmia and sudden cardiac death (VT/SCD)...
  78. Ilyas I, Alrumaih H, Rabbani S. Noncemented Total Hip Arthroplasty in Sickle-Cell Disease: Long-Term Results. J Arthroplasty. 2017;: pubmed publisher
    ..Avascular necrosis of the femoral head is a well-known sequela of sickle-cell disease (SCD) requiring a surgical intervention that comes with technical challenges...
  79. Carvalho M, Souza A, Carvalho M, Pacheco A, Rocha L, do Nascimento V, et al. Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease. Front Immunol. 2017;8:1491 pubmed publisher
    ..In summary, AAT may need to be included in studies related to SCD and in the discussion of further therapeutic strategies...
  80. Nio Y, Hasegawa H, Okamura H, Miyayama Y, Akahori Y, Hijikata M. Liver-specific mono-unsaturated fatty acid synthase-1 inhibitor for anti-hepatitis C treatment. Antiviral Res. 2016;132:262-7 pubmed publisher
    ..The results suggest that MK8245 is an option for anti-HCV multi-drug therapy with a low risk of emergence of drug-resistant HCV without significant side effects. ..
  81. Kucharski M, Kaczor U. [Stearoyl-CoA desaturase--the lipid metabolism regulator]. Postepy Hig Med Dosw (Online). 2014;68:334-42 pubmed publisher
    ..Also, it seems that using sheep as a potential animal model could be helpful in uncovering and understanding the mechanisms regulated by stearoyl-CoA desaturase. ..
  82. Magi S, Lariccia V, Maiolino M, Amoroso S, Gratteri S. Sudden cardiac death: focus on the genetics of channelopathies and cardiomyopathies. J Biomed Sci. 2017;24:56 pubmed publisher
    ..Functional alterations of the related proteins are also described. ..
  83. Nkya S, Mgaya J, Urio F, Makubi A, Thein S, Menzel S, et al. Fetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania. EBioMedicine. 2017;23:146-149 pubmed publisher
    ..In SCD, improving SpO2, in part through cardiovascular compensation and associated with reduced reticulocytosis, may be a mechanism by which HbF reduces disease severity. ..
  84. Leong I, Stuckey A, Belluoccio D, Fan V, Skinner J, Prosser D, et al. Massively Parallel Sequencing of Genes Implicated in Heritable Cardiac Disorders: A Strategy for a Small Diagnostic Laboratory. Med Sci (Basel). 2017;5: pubmed publisher
  85. Wang X, Wu C, Wang H, Gonsamo A, Liu Z. No evidence of widespread decline of snow cover on the Tibetan Plateau over 2000-2015. Sci Rep. 2017;7:14645 pubmed publisher
    ..The roles of temperature and precipitation on snow cover penology varied in different elevation zones, and the impact of both temperature and precipitation strengthened as elevation increases. ..
  86. Vogel J, Varga Doležalová M, La Joie R, Marks S, Schwimmer H, Landau S, et al. Subjective cognitive decline and β-amyloid burden predict cognitive change in healthy elderly. Neurology. 2017;89:2002-2009 pubmed publisher
    ..Evidence for amyloid alone is not sufficient to indicate risk of rapid cognitive decline in healthy elderly. Effects of GDS on cognitive decline in nondepressed cohorts may be driven by SCD rather than subsyndromal depression. ..
  87. Adegoke S, Braga J, D Adekile A, Figueiredo M. Impact of Hydroxyurea on Anthropometry and Serum 25-Hydroxyvitamin D Among Children With Sickle Cell Disease. J Pediatr Hematol Oncol. 2017;: pubmed publisher
    ..To evaluate the impact of hydroxyurea (HU) on nutritional status and serum 25-hydroxyvitamin D (25-OHD) of children with sickle cell disease (SCD)...
  88. Souza C, Vannice G, Neto J, Calder P. Is Palmitoleic Acid a Plausible Non-Pharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?. Mol Nutr Food Res. 2017;: pubmed publisher
    ..Therefore more human-based research is needed in order to identify whether palmitoleic acid meets the promising therapeutic potential suggested by the pre-clinical research. This article is protected by copyright. All rights reserved...
  89. Asadollahpour Nanaei H, Ansari Mahyari S, Edriss M. Effect of LEPR, ABCG2 and SCD1 gene polymorphisms on reproductive traits in the Iranian Holstein cattle. Reprod Domest Anim. 2014;49:769-74 pubmed publisher
    ..located in the ATP-binding cassette superfamily G member 2 transporter (ABCG2), stearoyl-CoA desaturase 1 (SCD1) and leptin receptor (LEPR) genes on reproductive traits and somatic cell count (SCC)...
  90. Wijnberge M, Parmar K, Kesse Adu R, Howard J, Cohen A, Hunt B. The utility of thromboelastography and thrombin generation in assessing the prothrombotic state of adults with sickle cell disease. Thromb Res. 2017;158:113-120 pubmed publisher