STC2

Summary

Gene Symbol: STC2
Description: stanniocalcin 2
Alias: STC-2, STCRP, stanniocalcin-2, STC-related protein, stanniocalcin-related protein
Species: human
Products:     STC2

Top Publications

  1. Joensuu K, Heikkila P, Andersson L. Tumor dormancy: elevated expression of stanniocalcins in late relapsing breast cancer. Cancer Lett. 2008;265:76-83 pubmed publisher
    ..These findings suggest that elevated expression of STC-1 or STC-2 act as survival factors also for breast cancer cells and thereby contribute to tumor dormancy. ..
  2. Yokobori T, Mimori K, Ishii H, Iwatsuki M, Tanaka F, Kamohara Y, et al. Clinical significance of stanniocalcin 2 as a prognostic marker in gastric cancer. Ann Surg Oncol. 2010;17:2601-7 pubmed publisher
    ..of gastric cancer and normal mucosa in a public microarray database showed that the expression level of Stanniocalcin 2 was higher in gastric cancer than in normal gastric mucosa...
  3. Law A, Wong C. Stanniocalcin-2 promotes epithelial-mesenchymal transition and invasiveness in hypoxic human ovarian cancer cells. Exp Cell Res. 2010;316:3425-34 pubmed publisher
    The human glycoprotein, stanniocalcin-2 (STC2) is a HIF-1 target gene that is found to be associated with tumor development...
  4. Moore E, Kuestner R, Conklin D, Whitmore T, Downey W, Buddle M, et al. Stanniocalcin 2: characterization of the protein and its localization to human pancreatic alpha cells. Horm Metab Res. 1999;31:406-14 pubmed
    ..The second homologue (STC2) is 30-38% identical to the fish stanniocalcins, and is characterized by unique cysteine and histidine motifs that ..
  5. Ishibashi K, Miyamoto K, Taketani Y, Morita K, Takeda E, Sasaki S, et al. Molecular cloning of a second human stanniocalcin homologue (STC2). Biochem Biophys Res Commun. 1998;250:252-8 pubmed
    ..Here we report the cloning of a second mammalian stanniocalcin (STC2) from the human osteosarcoma cDNA library. STC2 has 302 amino acid residues with 34% identity with STC1 and eel STC...
  6. Law A, Wong C. Stanniocalcin-1 and -2 promote angiogenic sprouting in HUVECs via VEGF/VEGFR2 and angiopoietin signaling pathways. Mol Cell Endocrinol. 2013;374:73-81 pubmed publisher
    ..We prepared STC1 or STC2 lentiviral particles to transduce the cells to reveal their effects on the processes of cell proliferation, ..
  7. Wang Y, Li L, Zhao Z, Wang H. Clinical utility of measuring expression levels of KAP1, TIMP1 and STC2 in peripheral blood of patients with gastric cancer. World J Surg Oncol. 2013;11:81 pubmed publisher
    We examined preoperative kinesin II-associated protein (KAP1), TIMP metallopeptidase inhibitor 1 (TIMP1) and stanniocalcin 2 (STC2) expression levels in patients with gastric cancers to assess their clinical application for diagnosing ..
  8. Law A, Lai K, Ip C, Wong A, Wagner G, Wong C. Epigenetic and HIF-1 regulation of stanniocalcin-2 expression in human cancer cells. Exp Cell Res. 2008;314:1823-30 pubmed publisher
    Mammalian stanniocalcin-2 (STC2) is a secreted glycoprotein hormone with a putative role in unfolded protein response and apoptosis...
  9. Tamura K, Furihata M, Chung S, Uemura M, Yoshioka H, Iiyama T, et al. Stanniocalcin 2 overexpression in castration-resistant prostate cancer and aggressive prostate cancer. Cancer Sci. 2009;100:914-9 pubmed publisher
    ..Among them, we report the identification of a new biomarker, stanniocalcin 2, as an overexpressed gene in castration-resistant prostate cancer cells...

More Information

Publications81

  1. Ieta K, Tanaka F, Yokobori T, Kita Y, Haraguchi N, Mimori K, et al. Clinicopathological significance of stanniocalcin 2 gene expression in colorectal cancer. Int J Cancer. 2009;125:926-31 pubmed publisher
    Laser microdissection (LMD) and microarray were used to identify genes associated with colorectal cancer. Stanniocalcin 2 (STC2) expression and clinicopathological significance in 139 clinical colorectal cancer samples were specifically ..
  2. Esseghir S, Kennedy A, Seedhar P, Nerurkar A, Poulsom R, Reis Filho J, et al. Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins. Clin Cancer Res. 2007;13:3164-73 pubmed
    ..3 (TSP3), insulin-like growth factor binding protein 7 (IGFBP7), tumor rejection antigen 1 (TRA1), stanniocalcin 2 (STC2), and netrin 4 (NTN4)...
  3. Kita Y, Mimori K, Iwatsuki M, Yokobori T, Ieta K, Tanaka F, et al. STC2: a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma. Ann Surg Oncol. 2011;18:261-72 pubmed publisher
    ..Oligo microarray analysis identified several lymph node-specific, metastasis-related genes. STC2 (stanniocalcin 2), which was overexpressed in esophageal cancer cases, was chosen for further characterization...
  4. Raulic S, Ramos Valdes Y, DiMattia G. Stanniocalcin 2 expression is regulated by hormone signalling and negatively affects breast cancer cell viability in vitro. J Endocrinol. 2008;197:517-29 pubmed publisher
    Stanniocalcin 1 (STC1) and STC2 are secreted, homodimeric glycoproteins that share 30% amino acid sequence identity...
  5. Volland S, Kugler W, Schweigerer L, Wilting J, Becker J. Stanniocalcin 2 promotes invasion and is associated with metastatic stages in neuroblastoma. Int J Cancer. 2009;125:2049-57 pubmed publisher
    b>Stanniocalcin 2 (STC2) is a secreted glycoprotein of as yet unknown functions. We investigated STC2 in human neuroblastoma, the most common solid extra-cranial tumor of infancy...
  6. Law A, Wong C. Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia. Exp Cell Res. 2010;316:466-76 pubmed publisher
    Stanniocalcin-2 (STC2), the paralog of STC1, has been suggested as a novel target of oxidative stress response to protect cells from apoptosis. The expression of STC2 has been reported to be highly correlated with human cancer development...
  7. Kashyap M, Pawar H, Keerthikumar S, Sharma J, Goel R, Mahmood R, et al. Evaluation of protein expression pattern of stanniocalcin 2, insulin-like growth factor-binding protein 7, inhibin beta A and four and a half LIM domains 1 in esophageal squamous cell carcinoma. Cancer Biomark. 2012;12:1-9 pubmed publisher
    ..We have validated expression of insulin-like growth factor-binding protein 7 (IGFBP7), stanniocalcin 2 (STC2), inhibin beta A (INHBA) and four and a half LIM domains 1 (FHL1)...
  8. Wang Y, Wu J, Xu J, Lin S. Clinical significance of high expression of stanniocalcin-2 in hepatocellular carcinoma. Biosci Rep. 2019;39: pubmed publisher
    To investigate the significance of stanniocalcin-2 (STC2) expression in hepatocellular carcinoma (HCC) tissues and adjacent tissues...
  9. Yang I, Jung J, Kim S, Yoo E, Cho N, Lee H, et al. ABT-263 exhibits apoptosis-inducing potential in oral cancer cells by targeting C/EBP-homologous protein. Cell Oncol (Dordr). 2019;: pubmed publisher
    ..Consistent with the microarray results, the mRNA expression levels of the top four genes (CHOP, TRB3, ASNS, and STC2) were found to be significantly increased...
  10. Cai M, Zhu Y, Li Z, Josephs Spaulding J, Zhou Y, Hu Y, et al. Profiling the Gene Expression and DNA Methylation in the Mouse Brain after Ischemic Preconditioning. Neuroscience. 2019;406:249-261 pubmed publisher
    ..Genes induced by IPC, including Arid5a, Nptx2 and Stc2, demonstrated a neuroprotective effect against oxygen-glucose deprivation induced neurotoxicity in vitro...
  11. Sah N, Kuehu D, Khadka V, Deng Y, Peplowska K, Jha R, et al. RNA sequencing-based analysis of the laying hen uterus revealed the novel genes and biological pathways involved in the eggshell biomineralization. Sci Rep. 2018;8:16853 pubmed publisher
    ..of mineralization), OTOP2 (modulator of cellular calcium influx), CALCB (intracellular release of Ca-ions), STC2 (increases alkaline phosphatase activity), and ATP2C2 (cellular import of Ca-ions) were significantly higher in the ..
  12. Sarapio E, Souza S, Vogt E, Rocha D, Fabres R, Trapp M, et al. Effects of stanniocalcin hormones on rat brown adipose tissue metabolism under fed and fasted conditions. Mol Cell Endocrinol. 2019;485:81-87 pubmed publisher
    ..the effect of fed and fasting (48 h) states on the expression of stanniocalcin-1 (Stc1) and stanniocalcin-2 (Stc2) in rat brown adipose tissue (BAT), as well as the in vitro effects of human stanniocalcin 1 and 2 (hSTC-1 and hSTC-..
  13. Wang J, Sahengbieke S, Xu X, Zhang L, Xu X, Sun L, et al. Gene expression analyses identify a relationship between stanniocalcin 2 and the malignant behavior of colorectal cancer. Onco Targets Ther. 2018;11:7155-7168 pubmed publisher
    Colorectal cancer (CRC) is one of the main causes of cancer-related death worldwide. Stanniocalcin 2 (STC2), a secreted glycoprotein, has been suggested to exert various functions in progression of many cancers...
  14. Oxvig C. The role of PAPP-A in the IGF system: location, location, location. J Cell Commun Signal. 2015;9:177-87 pubmed publisher
    ..The latter may involve the protein stanniocalcin-2 (STC2), recently found to potently inhibit PAPP-A activity by forming a covalent complex with PAPP-A...
  15. Al Khafaji H, Noer P, Alkharobi H, Alhodhodi A, Meade J, El Gendy R, et al. A characteristic signature of insulin-like growth factor (IGF) axis expression during osteogenic differentiation of human dental pulp cells (hDPCs): Potential co-ordinated regulation of IGF action. Growth Horm IGF Res. 2018;42-43:14-21 pubmed publisher
    ..this we report increased expression of IGF-2 (an activator of PAPP-A), and decreased expression of stanniocalcin-2 (STC2- a recently discovered inhibitor of PAPP-A) under osteogenic conditions...
  16. Joshi A, Carter D, Harper T, Elferink C. Aryl hydrocarbon receptor-dependent stanniocalcin 2 induction by cinnabarinic acid provides cytoprotection against endoplasmic reticulum and oxidative stress. J Pharmacol Exp Ther. 2015;353:201-12 pubmed publisher
    ..that activation of AhR by the tryptophan catabolite cinnabarinic acid (CA) directly upregulates expression of stanniocalcin 2 (Stc2) to elicit cytoprotection against apoptosis induced by endoplasmic reticulum stress and oxidative ..
  17. Roche F, Pietilä I, Kaito H, Sjöström E, Sobotzki N, Noguer O, et al. Leukocyte Differentiation by Histidine-Rich Glycoprotein/Stanniocalcin-2 Complex Regulates Murine Glioma Growth through Modulation of Antitumor Immunity. Mol Cancer Ther. 2018;17:1961-1972 pubmed publisher
    ..interaction-decoding technology, TRICEPS-based ligand receptor capture (LRC), we identified Stanniocalcin-2 (STC2) as an interacting partner of HRG on the surface of inflammatory cells in vitro and colocalization of HRG ..
  18. Jepsen M, Kløverpris S, Mikkelsen J, Pedersen J, Füchtbauer E, Laursen L, et al. Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis. J Biol Chem. 2015;290:3430-9 pubmed publisher
    Mammalian stanniocalcin-2 (STC2) is a secreted polypeptide widely expressed in developing and adult tissues...
  19. Brauze D, Zawierucha P, Kiwerska K, Bednarek K, Oleszak M, Rydzanicz M, et al. Induction of expression of aryl hydrocarbon receptor-dependent genes in human HepaRG cell line modified by shRNA and treated with ?-naphthoflavone. Mol Cell Biochem. 2017;425:59-75 pubmed publisher
    ..Among the AhR-dependent genes that are not involved in metabolism of xenobiotics SERPINB2, STC2, ARL4C, and TIPARP belong to the most inducible by BNF...
  20. Ge P, Xing N, Ren Y, Zhu L, Han D, Kuang H, et al. Preventive effect of American ginseng against premature ovarian failure in a rat model. Drug Dev Res. 2014;75:521-8 pubmed publisher
    ..PLA2G4A expression was positively correlated with POF, while the expression levels of PAPPA, STC2, CCL2, and NELL1 were negatively correlated with POF...
  21. Chen X, Liu Q, Huang W, Cai C, Xia W, Peng Y, et al. Stanniocalcin-2 contributes to mesenchymal stromal cells attenuating murine contact hypersensitivity mainly via reducing CD8+ Tc1 cells. Cell Death Dis. 2018;9:548 pubmed publisher
    ..Gene expression profiling revealed that STC2, but not STC1, was highly expressed in MSCs...
  22. Monget P, Oxvig C. PAPP-A and the IGF system. Ann Endocrinol (Paris). 2016;77:90-6 pubmed publisher
    ..Pro-MBP and stanniocalcin-2 (STC2) appear to be the main inhibitors of PAPP-A activity, by forming a covalent complex with the protease...
  23. Brantley K, Kjærsgaard A, Cronin Fenton D, Yacoub R, Nielsen A, Lauridsen K, et al. Stanniocalcin Expression as a Predictor of Late Breast Cancer Recurrence. Cancer Epidemiol Biomarkers Prev. 2018;27:653-659 pubmed publisher
    b>Background: Expression of human paracrine hormones stanniocalcin 1 (STC1) and stanniocalcin 2 (STC2) may potentiate late breast cancer recurrence...
  24. Roessler C, Agarwal R, Allaire M, Alonso Mori R, Andi B, Bachega J, et al. Acoustic Injectors for Drop-On-Demand Serial Femtosecond Crystallography. Structure. 2016;24:631-640 pubmed publisher
    ..We report crystal structures from lysozyme, thermolysin, and stachydrine demethylase (Stc2). Additional samples were screened to demonstrate that these methods can be applied to rare samples.
  25. Bøtkjær J, Borgbo T, Kløverpris S, Noer P, Oxvig C, Andersen C. Effect of pregnancy-associated plasma protein-A (PAPP-A) single-nucleotide polymorphisms on the level and activity of PAPP-A and the hormone profile in fluid from normal human small antral follicles. Fertil Steril. 2016;106:1778-1786.e8 pubmed publisher
    ..Genotyping and measurement of antigen levels of steroids, PAPP-A, stanniocalcin-2 (STC2), and antimüllerian hormone (AMH) plus activity of PAPP-A toward insulin-like growth factor binding protein 4 (..
  26. Bagordakis E, Sawazaki Calone I, Macedo C, Carnielli C, de Oliveira C, Rodrigues P, et al. Secretome profiling of oral squamous cell carcinoma-associated fibroblasts reveals organization and disassembly of extracellular matrix and collagen metabolic process signatures. Tumour Biol. 2016;37:9045-57 pubmed publisher
    ..were fibronectin type III domain-containing 1 (FNDC1), serpin peptidase inhibitor type 1 (SERPINE1), and stanniocalcin 2 (STC2), the upregulation of which was validated by quantitative PCR and ELISA in an independent set of CAF ..
  27. Kang M, Ding Y, Kim E, Choi Y, de Araujo T, Heo S, et al. Indole Derivatives Isolated from Brown Alga Sargassum thunbergii Inhibit Adipogenesis through AMPK Activation in 3T3-L1 Preadipocytes. Mar Drugs. 2017;15: pubmed publisher
    ..Together, these findings suggested that STC-1 and STC-5 may be effective candidates for the prevention of obesity or obesity-related diseases. ..
  28. Karthikeyan K, Barker K, Tang Y, Kahn P, Wiktor P, Brunner A, et al. A Contra Capture Protein Array Platform for Studying Post-translationally Modified (PTM) Auto-antigenomes. Mol Cell Proteomics. 2016;15:2324-37 pubmed publisher
    ..insulin like growth factor binding protein 6 (IGFBP6), insulin like growth factor I (IGF1) and stanniocalcin-2 (STC2)) in RA patients...
  29. Takabatake Y, Oxvig C, Nagi C, Adelson K, Jaffer S, Schmidt H, et al. Lactation opposes pappalysin-1-driven pregnancy-associated breast cancer. EMBO Mol Med. 2016;8:388-406 pubmed publisher
    ..found that the protective effect of lactation is associated with the expression of inhibitors of PAPP-A, STC1, and STC2. Collectively, these results identify PAPP-A as a pregnancy-dependent oncogene while also showing that extended ..
  30. Ueda H, Akiyama Y, Shimada S, Mogushi K, Serizawa M, Matsumura S, et al. Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs. Endocr Relat Cancer. 2018;25:619-631 pubmed publisher
    ..Among them, expression of five genes including STC2 was suppressed by DAXX/H3.3/H3K9me3 pathway...
  31. Hjortebjerg R, Berryman D, Comisford R, List E, Oxvig C, Bjerre M, et al. Depot-specific and GH-dependent regulation of IGF binding protein-4, pregnancy-associated plasma protein-A, and stanniocalcin-2 in murine adipose tissue. Growth Horm IGF Res. 2018;39:54-61 pubmed publisher
    ..Recently, stanniocalcin-2 (STC2) was discovered as an inhibitor of PAPP-A...
  32. Kløverpris S, Mikkelsen J, Pedersen J, Jepsen M, Laursen L, Petersen S, et al. Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A. J Biol Chem. 2015;290:21915-24 pubmed publisher
    ..It has recently been found that the homologous STC2 inhibits PAPP-A proteolytic activity, and that this depends on the formation of a covalent complex between the ..
  33. Zhou J, Li Y, Yang L, Wu Y, Zhou Y, Cui Y, et al. Stanniocalcin 2 improved osteoblast differentiation via phosphorylation of ERK. Mol Med Rep. 2016;14:5653-5659 pubmed publisher
    Mammalian stanniocalcin 2 (STC2) is a glycoprotein hormone with multiple functions. The present study determined the importance of STC2 in osteoblast differentiation...
  34. Carneiro M, Hu D, Archer J, Feng C, Afonso S, Chen C, et al. Dwarfism and Altered Craniofacial Development in Rabbits Is Caused by a 12.1 kb Deletion at the HMGA2 Locus. Genetics. 2017;205:955-965 pubmed publisher
    ..of regions of elevated genetic differentiation between dwarf and normal-size rabbits, including LCORL-NCAPG, STC2, HOXD cluster, and IGF2BP2 Levels and patterns of genetic diversity at the LCORL-NCAPG locus further suggest that ..
  35. Joshi A, Hossain E, Elferink C. Epigenetic Regulation by Agonist-Specific Aryl Hydrocarbon Receptor Recruitment of Metastasis-Associated Protein 2 Selectively Induces Stanniocalcin 2 Expression. Mol Pharmacol. 2017;92:366-374 pubmed publisher
    ..Recent studies identified stanniocalcin 2 (Stc2) as a novel AhR target gene responsive to the endogenous AhR agonist cinnabarinic acid (CA)...
  36. Ichikawa T, Horie Inoue K, Ikeda K, Blumberg B, Inoue S. Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells. J Mol Endocrinol. 2007;39:239-47 pubmed
    ..Among these up-regulated genes by MK-4, growth differentiation factor 15 (GDF15) and stanniocalcin 2 (STC2) were identified as novel MK-4 target genes independent of GGCX and SXR pathways in human and mouse ..
  37. Wu J, Lai M, Shao C, Wang J, Wei J. STC2 overexpression mediated by HMGA2 is a biomarker for aggressiveness of high-grade serous ovarian cancer. Oncol Rep. 2015;34:1494-502 pubmed publisher
    ..Based on the gene profiling analysis, we found that the potent EMT gene, stanniocalcin 2 (STC2), was highly correlated with HMGA2 expression...
  38. López J, Jardin I, Chamorro C, Duran M, Tarancón Rubio M, Reyes Panadero M, et al. Involvement of stanniocalcins in the deregulation of glycaemia in obese mice and type 2 diabetic patients. J Cell Mol Med. 2017;: pubmed publisher
    ..are expressed in the pancreas tissue, and it was suggested a direct correlation between circulating insulin and STC2 concentrations in human...
  39. Hou J, Wang Z, Xu H, Yang L, Yu X, Yang Z, et al. Stanniocalicin 2 suppresses breast cancer cell migration and invasion via the PKC/claudin-1-mediated signaling. PLoS ONE. 2015;10:e0122179 pubmed publisher
    ..b>STC2, a member of STC family, has been reported to be associated with tumor development...
  40. Gagliardi A, Kuo E, Raulic S, Wagner G, DiMattia G. Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs. Am J Physiol Endocrinol Metab. 2005;288:E92-105 pubmed
    ..Analysis of mouse Stc2 gene expression indicates that, unlike Stc1, it is not highly expressed during development but exhibits overlapping ..
  41. Arigami T, Uenosono Y, Ishigami S, Yanagita S, Hagihara T, Haraguchi N, et al. Clinical significance of stanniocalcin 2 expression as a predictor of tumor progression in gastric cancer. Oncol Rep. 2013;30:2838-44 pubmed publisher
    b>Stanniocalcin 2 (STC2) is a glycoprotein hormone that plays an important role in calcium and phosphate homeostasis...
  42. Yang S, Ji Q, Chang B, Wang Y, Zhu Y, Li D, et al. STC2 promotes head and neck squamous cell carcinoma metastasis through modulating the PI3K/AKT/Snail signaling. Oncotarget. 2017;8:5976-5991 pubmed publisher
    The mammalian peptide hormone stanniocalcin 2 (STC2) plays an oncogenic role in many human cancers. However, the exact function of STC2 in human head and neck squamous cell carcinoma (HNSCC) is unclear...
  43. Wang H, Wu K, Sun Y, Li Y, Wu M, Qiao Q, et al. STC2 is upregulated in hepatocellular carcinoma and promotes cell proliferation and migration in vitro. BMB Rep. 2012;45:629-34 pubmed
    The human glycoprotein, stanniocalcin 2 (STC2) plays multiple roles in several tumor types, however, its function and clinical significance in hepatocellular carcinoma (HCC) remain unclear...
  44. Shen X, Gu K, Shi J, Yao J, Wu J. Increased expression of stanniocalcin 2 is associated with tumor progression after radiotherapy in patients with cervical carcinoma. Int J Clin Exp Pathol. 2014;7:8770-6 pubmed
    This study aimed to analyze the expression, clinical significance of stanniocalcin 2 in cervical carcinoma patients who were treated with radiotherapy...
  45. Tarassishin L, Lim J, Weatherly D, Angeletti R, Lee S. Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression. J Proteomics. 2014;99:152-168 pubmed publisher
    ..05) compared to controls. Of these, IL-8, CCL2, TNC, Gal-1 and PTX3 were validated as upregulated and SERPINE1, STC2, CTGF and COL4A2 were validated as downregulated factors by immunochemical methods...
  46. Lin S, Guo Q, Wen J, Li C, Lin J, Cui X, et al. Survival analyses correlate stanniocalcin 2 overexpression to poor prognosis of nasopharyngeal carcinomas. J Exp Clin Cancer Res. 2014;33:26 pubmed publisher
    b>Stanniocalcin 2 (STC2) is overexpressed in several types of human cancers, and its overexpression positively correlates to tumor progression and poor prognosis...
  47. Jepsen M, Kløverpris S, Bøtkjær J, Wissing M, Andersen C, Oxvig C. The proteolytic activity of pregnancy-associated plasma protein-A is potentially regulated by stanniocalcin-1 and -2 during human ovarian follicle development. Hum Reprod. 2016;31:866-74 pubmed publisher
    ..proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) regulated by the stanniocalcins (STC1 and STC2) during human follicle maturation? The STCs and PAPP-A show similar expression by immunohistochemistry in ..
  48. Panagiotou G, Anastasilakis A, Kynigopoulos G, Skouvaklidou E, Saridakis Z, Upadhyay J, et al. Physiological parameters regulating circulating levels of the IGFBP-4/Stanniocalcin-2/PAPP-A axis. Metabolism. 2017;75:16-24 pubmed publisher
    ..001 for both). Intact, and to a lesser extent total, IGFBP-4 displayed a cortisol-like day/night variation. We report for the first time anthropometric and physiological modulators of ISPa serum levels in healthy humans. ..
  49. Jiao Y, Zhao J, Shi G, Liu X, Xiong X, Li X, et al. Stanniocalcin2 acts as an anorectic factor through activation of STAT3 pathway. Oncotarget. 2017;8:91067-91075 pubmed publisher
    ..In the present study, we show that stanniocalcin2 (STC2), a cytokine ubiquitously expressed and especially upregulated in many types of human cancers, has a regulatory ..
  50. Luo C, Pisarska M, Hsueh A. Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. Endocrinology. 2005;146:469-76 pubmed publisher
    ..Two related mammalian stanniocalcin genes, STC1 and STC2, were found to be expressed in various tissues as paracrine regulators...
  51. Johnston J, Ramos Valdes Y, Stanton L, Ladhani S, Beier F, DiMattia G. Human stanniocalcin-1 or -2 expressed in mice reduces bone size and severely inhibits cranial intramembranous bone growth. Transgenic Res. 2010;19:1017-39 pubmed publisher
    Stanniocalcin-1 (STC1) and -2 (STC2) are highly related, secreted, homodimeric glycoproteins that are significantly upregulated by different forms of stress including high phosphate levels...
  52. DiMattia G, Varghese R, Wagner G. Molecular cloning and characterization of stanniocalcin-related protein. Mol Cell Endocrinol. 1998;146:137-40 pubmed
    ..In this report we have described the cloning of an STC-like cDNA, designated here as STC related protein (STCrP)...
  53. Chang A, Reddel R. Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2. Mol Cell Endocrinol. 1998;141:95-9 pubmed
    ..In contrast to STC-1, the predicted amino acid sequence of STC-2 contains a cluster of histidine residues in the C-terminal portion of the protein, which suggests that STC-2 may interact with metal ions. ..
  54. Kim P, Na S, Lee B, Kim J, Cho J. Stanniocalcin 2 enhances mesenchymal stem cell survival by suppressing oxidative stress. BMB Rep. 2015;48:702-7 pubmed
    ..the disadvantages of stem cell-based cell therapy like low cell survival at the disease site, we used stanniocalcin 2 (STC2), a family of secreted glycoprotein hormones that function to inhibit apoptosis and oxidative damage ..
  55. Jansen M, Sas L, Sieuwerts A, Van Cauwenberghe C, Ramirez Ardila D, Look M, et al. Decreased expression of ABAT and STC2 hallmarks ER-positive inflammatory breast cancer and endocrine therapy resistance in advanced disease. Mol Oncol. 2015;9:1218-33 pubmed publisher
    ..metagene of six genes including the genes encoding for 4-aminobutyrate aminotransferase (ABAT) and Stanniocalcin-2 (STC2) were identified to distinguish 22 ER+ IBC from 43 ER+ nIBC patients and remained discriminatory in an independent ..
  56. Zhou H, Li Y, Zhang W, Lin D, Zhang W, Dong W. Expression of stanniocalcin-1 and stanniocalcin-2 in laryngeal squamous cell carcinoma and correlations with clinical and pathological parameters. PLoS ONE. 2014;9:e95466 pubmed publisher
    Stanniocalcin-1 (STC1) and stanniocalcin-2 (STC2) are secreted glycoprotein hormones involved in various types of human malignancies. The roles of STC1 and STC2 in laryngeal squamous cell carcinoma (LSCC) remain unknown...
  57. Wu F, Li T, Su S, Yu J, Zhang H, Tan G, et al. STC2 as a novel mediator for Mus81-dependent proliferation and survival in hepatocellular carcinoma. Cancer Lett. 2017;388:177-186 pubmed publisher
    ..Multilayered screenings, including DNA microarray, high content screen, and real-time PCR validation, identified STC2 as a proliferation-facilitating gene significantly down-regulated in HCC cells upon Mus81 knockdown...
  58. Yamamoto K, Tajima Y, Hasegawa A, Takahashi Y, Kojima M, Watanabe R, et al. Contrasting effects of stanniocalcin-related polypeptides on macrophage foam cell formation and vascular smooth muscle cell migration. Peptides. 2016;82:120-127 pubmed publisher
    ..Its human homologues, STC1 and STC2 showing 34% amino acid identity each other, are expressed in a variety of human tissues...
  59. Na S, Aldonza M, Sung H, Kim Y, Son Y, Cho S, et al. Stanniocalcin-2 (STC2): A potential lung cancer biomarker promotes lung cancer metastasis and progression. Biochim Biophys Acta. 2015;1854:668-76 pubmed publisher
    The homodimeric glycoprotein, stanniocalcin 2 (STC2) is previously known to be involved in the regulation of calcium and phosphate transport in the kidney and also reported to play multiple roles in several cancers...
  60. Jiang J, Westberg J, Andersson L. Stanniocalcin 2, forms a complex with heme oxygenase 1, binds hemin and is a heat shock protein. Biochem Biophys Res Commun. 2012;421:274-9 pubmed publisher
    b>Stanniocalcin 2 (STC2) is a homolog of stanniocalcin 1, a 56kD glycoprotein hormone that originally was found to confer calcitonin-like activity in fish...
  61. Chen B, Zeng X, He Y, Wang X, Liang Z, Liu J, et al. STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways. Oncotarget. 2016;7:71400-71416 pubmed publisher
    The STC2 protein involves in carcinogenesis and progression of many cancers. It remains unclear how STC2 regulates the epithelial-mesenchymal transition (EMT) process and colorectal cancer (CRC) development...
  62. Yuan Y, Yang Z, Zou Q, Li J, Li D, Liang L, et al. Comparative study of clinicopathological significance, BIRC7, and STC2 expression between squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder. Neoplasma. 2013;60:698-705 pubmed publisher
    ..The clinicopathological characteristics of SC/ASC have not been well documented. Expressions of BIRC7 and STC2 were observed in some tumors...
  63. Yoon J, Kim J, Kim K, Kim D, Jung S, Lee H, et al. Proteomic analysis of hypoxia-induced U373MG glioma secretome reveals novel hypoxia-dependent migration factors. Proteomics. 2014;14:1494-502 pubmed publisher
    ..Vascular endothelial growth factor, stanniocalcin 1 (STC1) and stanniocalcin 2, and insulin-like growth factor binding protein 3 and 6, enriched in the soluble fraction, and lysyl oxidase ..
  64. Miyazaki S, Kikuchi H, Iino I, Uehara T, Setoguchi T, Fujita T, et al. Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts. Int J Cancer. 2014;135:295-307 pubmed publisher
    ..In microarray analysis, stanniocalcin 2 (STC2) was the most highly upregulated gene in anti-VEGF antibody-treated tumors...
  65. Argente J, Chowen J, Perez Jurado L, Frystyk J, Oxvig C. One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology. EMBO Mol Med. 2017;9:1338-1345 pubmed publisher
    ..We also discuss the advances in the stanniocalcins (STC1 and STC2), proteins that modulate PAPP-A2, as well as PAPP-A...
  66. Jellinek D, Chang A, Larsen M, Wang X, Robinson P, Reddel R. Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells. Biochem J. 2000;350 Pt 2:453-61 pubmed
    Stanniocalcin 1 (STC1) and stanniocalcin 2 (STC2) are two recently identified mammalian peptide hormones. STC1 plays a role in calcium and phosphate homoeostasis, while the role of STC2 is unknown...
  67. Hashemzadeh S, Arabzadeh A, Estiar M, Sakhinia M, Mesbahi N, Emrahi L, et al. Clinical utility of measuring expression levels of Stanniocalcin 2 in patients with colorectal cancer. Med Oncol. 2014;31:237 pubmed publisher
    b>Stanniocalcin 2 (STC2) is a novel member of the Stanniocalcin family, the function of which remains unclear. Its expression is clinically significant in several cancers...
  68. Cheng H, Wu Z, Wu C, Wang X, Liow S, Li Z, et al. Overcoming STC2 mediated drug resistance through drug and gene co-delivery by PHB-PDMAEMA cationic polyester in liver cancer cells. Mater Sci Eng C Mater Biol Appl. 2018;83:210-217 pubmed publisher
    b>Stanniocalcin 2 (STC2) overexpression in hepatocellular carcinoma (HCC) could lead to poor prognosis, which might be due to its induced P-glycoprotein and Bcl-2 protein expression level increase...
  69. Marouli E, Graff M, Medina Gomez C, Lo K, Wood A, Kjaer T, et al. Rare and low-frequency coding variants alter human adult height. Nature. 2017;542:186-190 pubmed publisher
    ..1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants...
  70. Steffensen L, Conover C, Bjørklund M, Ledet T, Bentzon J, Oxvig C. Stanniocalcin-2 overexpression reduces atherosclerosis in hypercholesterolemic mice. Atherosclerosis. 2016;248:36-43 pubmed publisher
    ..Stanniocalcin-2 (STC2) was recently discovered to be a potent inhibitor of PAPP-A activity, but has not previously been implicated in ..
  71. Feng L, Ma J, Ji H, Liu Y, Hu W. MiR-184 Retarded the Proliferation, Invasiveness and Migration of Glioblastoma Cells by Repressing Stanniocalcin-2. Pathol Oncol Res. 2018;24:853-860 pubmed publisher
    To investigate the repression of miR-184 on Stanniocalcin-2 (STC2) and how this axis affects the propagation, invasiveness and migration ability of glioblastoma cells...
  72. Wang Y, Gao Y, Cheng H, Yang G, Tan W. Stanniocalcin 2 promotes cell proliferation and cisplatin resistance in cervical cancer. Biochem Biophys Res Commun. 2015;466:362-8 pubmed publisher
    ..We found in this study that stanniocalcin 2 (STC2) expression was upregulated in both cervical cancer tissues and cell lines...