STC1

Summary

Gene Symbol: STC1
Description: stanniocalcin 1
Alias: STC, stanniocalcin-1
Species: human
Products:     STC1

Top Publications

  1. Law A, Wong C. Stanniocalcin-1 and -2 promote angiogenic sprouting in HUVECs via VEGF/VEGFR2 and angiopoietin signaling pathways. Mol Cell Endocrinol. 2013;374:73-81 pubmed publisher
    ..We prepared STC1 or STC2 lentiviral particles to transduce the cells to reveal their effects on the processes of cell proliferation, ..
  2. Block G, Ohkouchi S, Fung F, Frenkel J, Gregory C, Pochampally R, et al. Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1. Stem Cells. 2009;27:670-681 pubmed publisher
    ..that the MSCs were activated by the apoptotic cells to increase synthesis and secretion of stanniocalcin-1 (STC-1), a peptide hormone that modulates mineral metabolism and has pleiotrophic effects that have not been fully ..
  3. Zhang K, Westberg J, Paetau A, von Boguslawsky K, Lindsberg P, Erlander M, et al. High expression of stanniocalcin in differentiated brain neurons. Am J Pathol. 1998;153:439-45 pubmed
    Stanniocalcin (STC) is a glycoprotein hormone first found in fish, in which it regulates calcium homeostasis and protects against hypercalcemia. Human and mouse stc cDNA were recently cloned...
  4. Varghese R, Wong C, Deol H, Wagner G, DiMattia G. Comparative analysis of mammalian stanniocalcin genes. Endocrinology. 1998;139:4714-25 pubmed
    The recent discovery of mammalian stanniocalcin (STC) prompted an investigation of its gene structure and expression pattern to study its function and regulation...
  5. Zhang K, Lindsberg P, Tatlisumak T, Kaste M, Olsen H, Andersson L. Stanniocalcin: A molecular guard of neurons during cerebral ischemia. Proc Natl Acad Sci U S A. 2000;97:3637-42 pubmed
    Stanniocalcin (STC) is a glycoprotein hormone originally found in bony fish, in which it regulates calcium/phosphate homeostasis and protects against hypercalcemia...
  6. Luo C, Kawamura K, Klein C, Hsueh A. Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors. Mol Endocrinol. 2004;18:2085-96 pubmed
    Stanniocalcin (STC) in fish maintains calcium and phosphate homeostasis, whereas mammalian STC1 shows a diverse tissue expression pattern with ovary exhibiting the highest level...
  7. Song H, Xu B, Yi J. Clinical significance of stanniocalcin-1 detected in peripheral blood and bone marrow of esophageal squamous cell carcinoma patients. J Exp Clin Cancer Res. 2012;31:35 pubmed publisher
    Stanniocalcin-1 (STC-1) is a potential marker of disseminated tumor cells (DTCs)...
  8. Shirakawa M, Fujiwara Y, Sugita Y, Moon J, Takiguchi S, Nakajima K, et al. Assessment of stanniocalcin-1 as a prognostic marker in human esophageal squamous cell carcinoma. Oncol Rep. 2012;27:940-6 pubmed publisher
    Stanniocalcin-1 (STC1) is a secreted glycoprotein hormone and highly expressed in various types of human malignancies...
  9. Chen C, Jamaluddin M, Yan S, Sheikh Hamad D, Yao Q. Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells. Arterioscler Thromb Vasc Biol. 2008;28:906-12 pubmed publisher
    Our previous studies revealed upregulation of stanniocalcin-1 (STC1) in cardiac vessels in dilated cardiomyopathy. However, the functional significance of STC1 is unknown...

More Information

Publications82

  1. Law A, Ching L, Lai K, Wong C. Identification and characterization of the hypoxia-responsive element in human stanniocalcin-1 gene. Mol Cell Endocrinol. 2010;314:118-27 pubmed publisher
    In this study, we aimed to identify the hypoxia-inducible factor-1 (HIF-1) binding motif in human STC1 gene promoter and to characterize the associated gene transactivation mechanism...
  2. Lai K, Law A, Yeung H, Lee L, Wagner G, Wong C. Induction of stanniocalcin-1 expression in apoptotic human nasopharyngeal cancer cells by p53. Biochem Biophys Res Commun. 2007;356:968-75 pubmed
    There is growing evidence to suggest that altered patterns of STC1 gene expression relate to the process of human cancer development...
  3. Liu G, Yang G, Chang B, Mercado Uribe I, Huang M, Zheng J, et al. Stanniocalcin 1 and ovarian tumorigenesis. J Natl Cancer Inst. 2010;102:812-27 pubmed publisher
    b>Stanniocalcin 1 (STC1) is a secreted glycoprotein hormone. High expression of STC1 has been associated with several cancers including ovarian cancer, but its role in the development of ovarian cancer is not clear...
  4. McCudden C, James K, Hasilo C, Wagner G. Characterization of mammalian stanniocalcin receptors. Mitochondrial targeting of ligand and receptor for regulation of cellular metabolism. J Biol Chem. 2002;277:45249-58 pubmed
    The polypeptide hormone stanniocalcin (STC) is widely expressed in mammalian tissues...
  5. Arigami T, Uenosono Y, Ishigami S, Hagihara T, Haraguchi N, Matsushita D, et al. Expression of stanniocalcin 1 as a potential biomarker of gastric cancer. Oncology. 2012;83:158-64 pubmed publisher
    We investigated stanniocalcin 1 (STC 1) expression to assess its clinical utility as a blood marker in patients with gastric cancer and evaluated its biological impact in terms of tumor aggressiveness...
  6. Guo F, Li Y, Wang J, Li Y, Li Y, Li G. Stanniocalcin1 (STC1) Inhibits Cell Proliferation and Invasion of Cervical Cancer Cells. PLoS ONE. 2013;8:e53989 pubmed publisher
    b>STC1 is a glycoprotein hormone involved in calcium/phosphate (Pi) homeostasis. There is mounting evidence that STC1 is tightly associated with the development of cancer. But the function of STC1 in cancer is not fully understood...
  7. Tohmiya Y, Koide Y, Fujimaki S, Harigae H, Funato T, Kaku M, et al. Stanniocalcin-1 as a novel marker to detect minimal residual disease of human leukemia. Tohoku J Exp Med. 2004;204:125-33 pubmed
    Stanniocalcin is a glycoprotein hormone that regulates the calcium level in fish. We found that mRNA of human stanniocalcin 1 (STC-1) is detectable in phytohemagglutinin-stimulated T cells and in most human leukemia cell lines, ..
  8. Tamura S, Oshima T, Yoshihara K, Kanazawa A, Yamada T, Inagaki D, et al. Clinical significance of STC1 gene expression in patients with colorectal cancer. Anticancer Res. 2011;31:325-9 pubmed
    Recent studies suggest that altered patterns of stanniocalcin 1 (STC1) gene expression have a role in human carcinogenesis...
  9. Wagner G, Guiraudon C, Milliken C, Copp D. Immunological and biological evidence for a stanniocalcin-like hormone in human kidney. Proc Natl Acad Sci U S A. 1995;92:1871-5 pubmed
    The corpuscles of Stannius are responsible for the synthesis and secretion of stanniocalcin (STC), a glycoprotein hormone that regulates calcium and phosphate homeostasis in fishes through its actions on the gills and kidneys...
  10. Sheikh Hamad D, Bick R, Wu G, Christensen B, Razeghi P, Poindexter B, et al. Stanniocalcin-1 is a naturally occurring L-channel inhibitor in cardiomyocytes: relevance to human heart failure. Am J Physiol Heart Circ Physiol. 2003;285:H442-8 pubmed
    ..Because the mammalian counterpart of the fish calcium-regulating hormone stanniocalcin-1 (STC1) is expressed in the heart, we reasoned that STC1 might play a role in the adaptive-maladaptive processes that lead ..
  11. Du Y, Gu X, Li L, Gao F. The diagnostic value of circulating stanniocalcin-1 mRNA in non-small cell lung cancer. J Surg Oncol. 2011;104:836-40 pubmed publisher
    Previous studies have suggested that the aberrant expression of Stanniocalcin-1 (STC1) occurs in tumor cells...
  12. Serlachius M, Alitalo R, Olsen H, Andersson L. Expression of stanniocalcin-1 in megakaryocytes and platelets. Br J Haematol. 2002;119:359-63 pubmed
    Stanniocalcin-1 (STC) is a 56-kDa homodimeric glycoprotein hormone originally found in fish, in which it regulates calcium/phosphate homeostasis and protects against toxic hypercalcaemia...
  13. Serlachius M, Andersson L. Upregulated expression of stanniocalcin-1 during adipogenesis. Exp Cell Res. 2004;296:256-64 pubmed
    Stanniocalcin-1 (STC-1) is a 56-kDa homodimeric protein originally discovered in bony fish, where it protects against toxic levels of environmental calcium by lowering the uptake of calcium via the gills and by increasing the ..
  14. Chakraborty A, Brooks H, Zhang P, Smith W, McReynolds M, Hoying J, et al. Stanniocalcin-1 regulates endothelial gene expression and modulates transendothelial migration of leukocytes. Am J Physiol Renal Physiol. 2007;292:F895-904 pubmed
    The mammalian counterpart of the fish calcium-regulating hormone stanniocalcin-1 (STC1) inhibits monocyte chemotactic protein-1- and stromal-derived factor-1alpha (SDF-1alpha)-mediated chemotaxis and diminishes chemokinesis in macrophage-..
  15. Jellinek D, Chang A, Larsen M, Wang X, Robinson P, Reddel R. Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells. Biochem J. 2000;350 Pt 2:453-61 pubmed
    b>Stanniocalcin 1 (STC1) and stanniocalcin 2 (STC2) are two recently identified mammalian peptide hormones. STC1 plays a role in calcium and phosphate homoeostasis, while the role of STC2 is unknown...
  16. Macartney Coxson D, Hood K, Shi H, Ward T, Wiles A, O Connor R, et al. Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level. BMC Cancer. 2008;8:187 pubmed publisher
    ..ADAMDEC1 mRNA and protein expression decreased during both tumourigenesis and tumour progression. Increased STC1 and LOXL2 mRNA expression occurred during tumourigenesis...
  17. Chang A, Janosi J, Hulsbeek M, De Jong D, Jeffrey K, Noble J, et al. A novel human cDNA highly homologous to the fish hormone stanniocalcin. Mol Cell Endocrinol. 1995;112:241-7 pubmed
    ..We conclude that a human protein similar to the fish hormone is expressed in multiple tissues rather than by a specialized endocrine organ. ..
  18. Law A, Yeung B, Ching L, Wong C. Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29. J Cell Biochem. 2011;112:2089-96 pubmed publisher
    Our previous study demonstrated that, stanniocalcin-1 (STC1) was a target of histone deacetylase (HDAC) inhibitors and was involved in trichostatin A (TSA) induced apoptosis in the human colon cancer cells, HT29...
  19. Joensuu K, Heikkila P, Andersson L. Tumor dormancy: elevated expression of stanniocalcins in late relapsing breast cancer. Cancer Lett. 2008;265:76-83 pubmed publisher
    ..The biology behind this phenomenon of tumor dormancy is poorly understood. The stanniocalcins (stanniocalcin-1, STC-1 and stanniocalcin-2, STC-2) are 56kDa homodimeric proteins...
  20. Holmes D, Zachary I. Vascular endothelial growth factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth factor-2. Cell Signal. 2008;20:569-79 pubmed publisher
    Stanniocalcin-1 (STC-1) is a glycoprotein hormone originally identified as a regulator of calcium and phosphate homeostasis in bony fish...
  21. Wu S, Yoshiko Y, De Luca F. Stanniocalcin 1 acts as a paracrine regulator of growth plate chondrogenesis. J Biol Chem. 2006;281:5120-7 pubmed
    During embryogenesis, the expression of mammalian stanniocalcin (STC1) in the appendicular skeleton suggests its involvement in the regulation of longitudinal bone growth...
  22. Yeung H, Lai K, Chan H, Mak N, Wagner G, Wong C. Hypoxia-inducible factor-1-mediated activation of stanniocalcin-1 in human cancer cells. Endocrinology. 2005;146:4951-60 pubmed
    Stanniocalcin-1 (STC1) is an endocrine hormone originally discovered in the corpuscles of Stannius, endocrine glands on kidneys of bony fishes, and also has been identified in mammals...
  23. McCudden C, Majewski A, Chakrabarti S, Wagner G. Co-localization of stanniocalcin-1 ligand and receptor in human breast carcinomas. Mol Cell Endocrinol. 2004;213:167-72 pubmed
    Stanniocalcin-1 (STC1) is a new polypeptide hormone that has metabolic effects on target cell mitochondria. Recent studies have shown that the STC1 gene is upregulated in primary breast tumors and co-expressed with the estrogen receptor...
  24. Law A, Lai K, Lui W, Wan H, Wong C. Histone deacetylase inhibitor-induced cellular apoptosis involves stanniocalcin-1 activation. Exp Cell Res. 2008;314:2975-84 pubmed publisher
    Our previous studies have demonstrated the involvement of HIF-1 and p53 in the regulation of stanniocalcin-1 (STC1) gene transcription in human cancer cells...
  25. Liang P, Averboukh L, Keyomarsi K, Sager R, Pardee A. Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells. Cancer Res. 1992;52:6966-8 pubmed
    ..Northern analysis confirmed its differential expression. Thus, this method can be used for detecting, cloning, and sequencing of genes that are unique to a host of biological and disease processes. ..
  26. Westberg J, Serlachius M, Lankila P, Penkowa M, Hidalgo J, Andersson L. Hypoxic preconditioning induces neuroprotective stanniocalcin-1 in brain via IL-6 signaling. Stroke. 2007;38:1025-30 pubmed
    ..Stanniocalcin-1 (STC-1) is a 56-kDa homodimeric glycoprotein originally discovered in bony fish, where it regulates calcium/phosphate ..
  27. He L, Wang T, Gao Q, Zhao G, Huang Y, Yu L, et al. Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells. J Biomed Sci. 2011;18:39 pubmed publisher
    Stanniocalcin-1(STC-1) is up-regulated in several cancers including gastric cancer. Evidences suggest that STC-1 is associated with carcinogenesis and angiogenic process...
  28. Chang A, Jellinek D, Reddel R. Mammalian stanniocalcins and cancer. Endocr Relat Cancer. 2003;10:359-73 pubmed
    ..The related mammalian proteins, STC1 and STC2, are expressed in a wide variety of tissues...
  29. Olsen H, Cepeda M, Zhang Q, Rosen C, Vozzolo B, Wagner G. Human stanniocalcin: a possible hormonal regulator of mineral metabolism. Proc Natl Acad Sci U S A. 1996;93:1792-6 pubmed
    We have isolated a human cDNA clone encoding the mammalian homolog of stanniocalcin (STC), a calcium- and phosphate-regulating hormone that was first described in fishes where it functions in preventing hypercalcemia...
  30. Varghese R, Gagliardi A, Bialek P, Yee S, Wagner G, DiMattia G. Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice. Endocrinology. 2002;143:868-76 pubmed
    In mammals stanniocalcin (STC) is widely expressed, and in the kidney and gut it regulates serum calcium levels by promoting phosphate reabsorption...
  31. Peña C, Céspedes M, Lindh M, Kiflemariam S, Mezheyeuski A, Edqvist P, et al. STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer. Cancer Res. 2013;73:1287-97 pubmed publisher
    ..Here, we report the identification of the secreted glycoprotein stanniocalcin-1 (STC1) as a mediator of metastasis by PDGF receptor function in the setting of colorectal cancer...
  32. Meng J, Yao Z, He Y, Zhang R, Yang H, Yao X, et al. Long non-coding RNA expression profiles in different severity EV71-infected hand foot and mouth disease patients. Biochem Biophys Res Commun. 2017;493:1594-1600 pubmed publisher
    ..on the dynamic changed lncRNAs, we performed systematic bioinformatics analysis with Series Test of Cluster (STC) algorithm, Gene Ontology (GO) analysis, pathway analysis and lncRNA-mRNA co-expression network analysis, and ..
  33. Ge X, Tian H, Ding C, Gu L, Wei Y, Gong J, et al. Fecal Microbiota Transplantation in Combination with Soluble Dietary Fiber for Treatment of Slow Transit Constipation: A Pilot Study. Arch Med Res. 2016;47:236-42 pubmed publisher
    ..launched this study to evaluate the efficacy and safety of FMT combined with fiber for slow transit constipation (STC). We performed a study of 21 patients with STC...
  34. Anderson C, Lazard D, Hartley D. Plasticity in bilateral superior temporal cortex: Effects of deafness and cochlear implantation on auditory and visual speech processing. Hear Res. 2017;343:138-149 pubmed publisher
    ..Superior temporal cortex (STC), including auditory association areas, plays a crucial role in the processing of auditory and visual speech ..
  35. Wang N, Edmiston E, Luo X, Yang H, Chang M, Wang F, et al. Comparing abnormalities of amplitude of low-frequency fluctuations in multiple system atrophy and idiopathic Parkinson's disease measured with resting-state fMRI. Psychiatry Res Neuroimaging. 2017;269:73-81 pubmed publisher
    ..Our findings suggested shared and distinct spontaneous brain activity abnormalities in striato-thalamo-cortical (STC) loop, default mood network, visual associative cortices and cerebellum were present in MSA and IPD, which may help ..
  36. Silk J, Lee K, Kerestes R, Griffith J, Dahl R, Ladouceur C. "Loser" or "Popular"?: Neural response to social status words in adolescents with major depressive disorder. Dev Cogn Neurosci. 2017;28:1-11 pubmed publisher
    ..depressed youth showed reduced late activation to social status (vs neutral) words in the superior temporal cortex (STC) and medial prefrontal cortex (MPFC); whereas healthy youth did not show any significant differences between word ..
  37. Xiang H, Tao X, Xia S, Qu J, Song H, Liu J, et al. Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Acinar Cell Injury via MicroRNA-30a-5p-Mediated Inhibition of High-Temperature Requirement A/Transforming Growth Factor Beta 1 Inflammatory Signaling. Front Immunol. 2017;8:1488 pubmed publisher
    ..this paper, we investigated the protective effects and molecular mechanism of emodin against sodium taurocholate (STC)-induced pancreatic acinar cells injury in vitro and in vivo; and the results showed that emodin ..
  38. Sartorio F, Vercelli S, Bravini E, Zanetta A, Bargeri S, Pisano F, et al. Assessment of dexterity and diagnostic accuracy of the Functional Dexterity Test in patients with carpal tunnel syndrome. Med Lav. 2018;109:31-39 pubmed publisher
    The diagnosis of carpal tunnel syndrome (STC) is centered on the symptoms. However, patients also show an impairment of sensorimotor functions, but the relationship between STC and manual dexterity has never been investigated...
  39. Li K, Dong D, Yao L, Dai D, Gu X, Guo L. Identification of STC1 as an beta-amyloid activated gene in human brain microvascular endothelial cells using cDNA microarray. Biochem Biophys Res Commun. 2008;376:399-403 pubmed publisher
    ..Among these genes, we found that the gene for a well-characterized calcium-regulating hormone, stanniocalcin-1 (STC1) was specifically up-regulated by Abeta treatment in a time and dose-dependent manner...
  40. Lee S, Naesens M, Li L, Sarwal M. Stanniocalcin supports the functional adaptation of adult-sized kidneys transplanted into the pediatric recipients. Transplantation. 2012;93:1130-5 pubmed publisher
    ..The single gene that correlated best with aGFR was stanniocalcin 1 (STC1)...
  41. Zhou H, Li Y, Zhang W, Lin D, Zhang W, Dong W. Expression of stanniocalcin-1 and stanniocalcin-2 in laryngeal squamous cell carcinoma and correlations with clinical and pathological parameters. PLoS ONE. 2014;9:e95466 pubmed publisher
    Stanniocalcin-1 (STC1) and stanniocalcin-2 (STC2) are secreted glycoprotein hormones involved in various types of human malignancies. The roles of STC1 and STC2 in laryngeal squamous cell carcinoma (LSCC) remain unknown...
  42. Budna J, Bryja A, Celichowski P, Kranc W, Ciesiółka S, Borys S, et al. "Bone Development" Is an Ontology Group Upregulated in Porcine Oocytes Before In Vitro Maturation: A Microarray Approach. DNA Cell Biol. 2017;36:638-646 pubmed publisher
    ..analysis, we found eight different transcripts, including IHH, BMP1, WWTR1, CHRDL1, KLF10, EIF2AK3, MMP14, and STC1. Their expression is related to the "bone development" ontology group and was further subjected to hierarchical ..
  43. Zlot C, Ingle G, Hongo J, Yang S, Sheng Z, Schwall R, et al. Stanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte growth factor. J Biol Chem. 2003;278:47654-9 pubmed
    b>Stanniocalcin 1 (STC1) is a secreted glycoprotein originally described as a hormone involved in calcium and phosphate homeostasis in bony fishes...
  44. López J, Jardin I, Chamorro C, Duran M, Tarancón Rubio M, Reyes Panadero M, et al. Involvement of stanniocalcins in the deregulation of glycaemia in obese mice and type 2 diabetic patients. J Cell Mol Med. 2017;: pubmed publisher
    ..Here, we show a significant correlation between STC1 and both glycaemia and glycosylated haemoglobin among DM2 patients, while DM2 patients who present the greatest ..
  45. Panagiotou G, Anastasilakis A, Kynigopoulos G, Skouvaklidou E, Saridakis Z, Upadhyay J, et al. Physiological parameters regulating circulating levels of the IGFBP-4/Stanniocalcin-2/PAPP-A axis. Metabolism. 2017;75:16-24 pubmed publisher
    Insulin Growth Factor Binding Protein 4 (IGFBP-4), Stanniocalcin-2 (STC-2) and Pregnancy-Associated Plasma Protein-A (PAPP-A) have a well-documented involvement in several physiological functions in humans but predictors of their ..
  46. Chang A, Doherty J, Huschtscha L, Redvers R, Restall C, Reddel R, et al. STC1 expression is associated with tumor growth and metastasis in breast cancer. Clin Exp Metastasis. 2015;32:15-27 pubmed publisher
    Stanniocalcin-1 (STC1) is a secreted glycoprotein implicated in several pathologies including retinal degeneration, cerebral ischemia, angiogenesis and inflammation...
  47. Camardo Leggieri M, Decontardi S, Bertuzzi T, Pietri A, Battilani P. Modeling Growth and Toxin Production of Toxigenic Fungi Signaled in Cheese under Different Temperature and Water Activity Regimes. Toxins (Basel). 2016;9: pubmed publisher
    ..Bete function described also STC, PA, ROQ-C and OTA production as well as function of T...
  48. Ling J, Zhang W, Xu B, Qiu W, Wang Y. [Experimental study of Bisacodyl in the treatment of slow transit constipation model rats]. Zhonghua Wei Chang Wai Ke Za Zhi. 2016;19:1365-1369 pubmed
    ..Twenty rats received intragastric diphenoxylate to develop slow transit constipation (STC) model, and 10 untreated rats were set as blank control...
  49. Gäbel G, Northoff B, Weinzierl I, Ludwig S, Hinterseher I, Wilfert W, et al. Molecular Fingerprint for Terminal Abdominal Aortic Aneurysm Disease. J Am Heart Assoc. 2017;6: pubmed publisher
    ..i>FCGBP), and a second set containing 5 genes exclusively upregulated in rAAA (ADAMTS9, STC1, GFPT2, GAL3ST4, CCL4L1)...
  50. Ge X, Ding C, Gong J, Tian H, Wei Y, Chen Q, et al. [Short-term efficacy on fecal microbiota transplantation combined with soluble dietary fiber and probiotics in the treatment of slow transit constipation]. Zhonghua Wei Chang Wai Ke Za Zhi. 2016;19:1355-1359 pubmed
    ..microbiota transplantation (FMT) combined with soluble dietary fiber and probiotics for slow transit constipation(STC)...
  51. Lu L, Yan G, Sun J. A study of human colonic motility in healthy and constipated subjects using the wireless capsule. Comput Biol Med. 2015;65:269-78 pubmed publisher
    ..NTC) are significantly lower compared to healthy subjects, whereas patients with slow transit constipation (STC) did not show significant differences...
  52. Jiang X, Futera Z, Ali M, Gajdos F, von Rudorff G, Carof A, et al. Cysteine Linkages Accelerate Electron Flow through Tetra-Heme Protein STC. J Am Chem Soc. 2017;: pubmed publisher
    ..we report the set of heme-heme theoretical ET rate constants that define electron flow in the tetra-heme protein STC by combining a novel projector-operator diabatization approach for electronic coupling calculation with molecular ..
  53. Cornmark L, Lønne G, Jögi A, Larsson C. Protein kinase C? suppresses the expression of STC1 in MDA-MB-231 breast cancer cells. Tumour Biol. 2011;32:1023-30 pubmed publisher
    ..The STC1 mRNA, encoding stanniocalcin 1, was particularly up-regulated following depletion of PKC? and was also induced by hypoxia...
  54. Gao Y, Li J, Su M, Li Y. [Acupuncture with smoothing liver and regulating qi for post-stroke slow transit constipation and its gastrointestinal hormone level]. Zhongguo Zhen Jiu. 2017;37:125-129 pubmed publisher
    To compare the efficacy between acupuncture with smoothing liver and regulating qi and lactulose for post-stroke slow transit constipation(STC) and to explore the mechanism.
  55. Roddy G, Yasumura D, Matthes M, Alavi M, Boye S, Rosa R, et al. Long-term photoreceptor rescue in two rodent models of retinitis pigmentosa by adeno-associated virus delivery of Stanniocalcin-1. Exp Eye Res. 2017;165:175-181 pubmed publisher
    ..We previously found that Stanniocalcin-1 (STC-1) reduced photoreceptor loss in the S334ter-3 and Royal College of Surgeons rat models of retinal degeneration...
  56. Jeon M, Han J, Nam S, Lee J, Kim S. STC-1 expression is upregulated through an Akt/NF-?B-dependent pathway in triple-negative breast cancer cells. Oncol Rep. 2016;36:1717-22 pubmed publisher
    Stanniocalcin-1 (STC-1) is a secreted glycoprotein and its expression is strongly correlated with cancer development. However, regulatory mechanism of STC-1 expression in breast cancer cells is not clear...
  57. Nomura M, Aoyama K, Ishibashi T. Sterigmatocystin and aflatoxin B1 contamination of corn, soybean meal, and formula feed in Japan. Mycotoxin Res. 2018;34:21-27 pubmed publisher
    Sterigmatocystin (STC) and aflatoxin B1 (AFB1) were analyzed in 246 corn samples, 126 soybean meal samples, and 861 formula feed samples from the Japanese market between April 2010 and March 2015...
  58. Lee C, Hwang I, Park C, Lee H, Park D, Kang S, et al. Expression of stanniocalcin-1 in culprit coronary plaques of patients with acute myocardial infarction or stable angina. J Clin Pathol. 2013;66:787-91 pubmed publisher
    Stanniocalcin-1 (STC1) is involved in fundamental biological processes such as angiogenesis, inflammation and wound healing, but little is known about its expression in human coronary atherosclerotic plaques or its relationship to plaque ..
  59. Namai F, Shigemori S, Sudo K, Sato T, Yamamoto Y, Nigar S, et al. Recombinant Mouse Osteocalcin Secreted by Lactococcus lactis Promotes Glucagon-Like Peptide-1 Induction in STC-1 Cells. Curr Microbiol. 2018;75:92-98 pubmed publisher
    ..An in vitro assay showed that purified rOC promotes GLP-1 secretion in a mouse intestinal neuroendocrine cell line, STC-1, in a dose-dependent manner...
  60. Łaniewski P, Baek C, Roland K, Curtiss R. Analysis of Spleen-Induced Fimbria Production in Recombinant Attenuated Salmonella enterica Serovar Typhimurium Vaccine Strains. MBio. 2017;8: pubmed publisher
    ..expression technology (IVET) strategy to identify four fimbrial operons, agf, saf, sti, and stc that are expressed in the spleen...
  61. Dabbs G, Zabecki M. Slot-type fractures of the scapula at New Kingdom Tell El-Amarna, Egypt. Int J Paleopathol. 2015;11:12-22 pubmed publisher
    ..Five adult males excavated from the South Tombs Cemetery (STC) (total n>400) at Amarna exhibit slot-type fracture lesions of the scapula, and two of these lesions exhibit ..
  62. Oplatowska Stachowiak M, Kleintjens T, Sajic N, Haasnoot W, Campbell K, Elliott C, et al. T-2 Toxin/HT-2 Toxin and Ochratoxin A ELISAs Development and In-House Validation in Food in Accordance with the Commission Regulation (EU) No 519/2014. Toxins (Basel). 2017;9: pubmed publisher
    ..be suitable for the detection of T-2/HT-2 in cereals and baby food at and above the screening target concentration (STC) of 12.5 ?g/kg and 7.5 ?g/kg, respectively...
  63. Yang L, Wang L, Zhu C, Wu J, Yuan Y, Yu L, et al. Laminarin counteracts diet-induced obesity associated with glucagon-like peptide-1 secretion. Oncotarget. 2017;8:99470-99481 pubmed publisher
    ..Then, STC-1 cells were adopted to address the underlying mechanism, by which laminarin promoted GLP-1 secretion in vitro
  64. Okuno H, Minatohara K, Bito H. Inverse synaptic tagging: An inactive synapse-specific mechanism to capture activity-induced Arc/arg3.1 and to locally regulate spatial distribution of synaptic weights. Semin Cell Dev Biol. 2018;77:43-50 pubmed publisher
    ..The synaptic tagging and capture (STC) hypothesis has provided a theoretical framework on how products of activity-dependent genes may interact with ..
  65. Li Y, He Z, Zhang X, Liu Q, Chen C, Zhu Z, et al. Stanniocalcin-1 augments stem-like traits of glioblastoma cells through binding and activating NOTCH1. Cancer Lett. 2018;416:66-74 pubmed publisher
    ..Here, we showed that Stanniocalcin-1 (STC1), a secretory glycoprotein, functions as a novel stimulator for stem-like traits of GBM cells...
  66. Hiatt M, Casey M, Lynch H, Snyder C, Stacey M, Walters R. Efficacy of proximal colectomy for surgical management of right-sided first colorectal cancer in Lynch Syndrome mutation carriers. Am J Surg. 2018;216:99-105 pubmed publisher
    ..of metachronous CRC, and survival after proximal colectomy (PC) compared with total (TC) and subtotal colectomy (STC) for right-sided first CRC in LS mutation carriers...
  67. Wu Y, Lin J, Han B, Wang L, Chen Y, Liu M, et al. Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. Reprod Domest Anim. 2017;: pubmed publisher
    ..g. ADAMTS9, CD14, CTNNB1, FST, GCLC, HSPG2, IGFBP2, IGFBP6, INHBA, PRL, PAPPA, POSTN, PRDX1, SERPINA1, SOD3, STC1, VEGFC, etc.). However, a higher abundance was observed for proteasome proteins...
  68. Liu D, Huang L, Wang Y, Wang W, Wehrens X, Belousova T, et al. Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway. PLoS ONE. 2012;7:e36994 pubmed publisher
    We have previously shown increased cardiac stanniocalcin-1 (STC1) in patients with idiopathic dilated cardiomyopathy...
  69. Ok H, Tian F, Hong E, Paek O, Kim S, Kim D, et al. Harmonized Collaborative Validation of Aflatoxins and Sterigmatocystin in White Rice and Sorghum by Liquid Chromatography Coupled to Tandem Mass Spectrometry. Toxins (Basel). 2016;8: pubmed
    ..mass spectrometry (LC/MS/MS) method for the simultaneous determination of aflatoxins and sterigmatocystin (STC) in white rice and sorghum (Sorghum bicolor)...
  70. Lin Y, Chen G, Wu S. Carbohydrates-chitosan composite carrier for Vero cell culture. Cytotechnology. 2016;68:2649-2658 pubmed
    ..Our results show that among these composites, 30 % starch-chitosan composite (STC) were the best carriers for the growth of Vero cells...
  71. Schein V, Kucharski L, Guerreiro P, Martins T, Morgado I, Power D, et al. Stanniocalcin 1 effects on the renal gluconeogenesis pathway in rat and fish. Mol Cell Endocrinol. 2015;414:1-8 pubmed publisher
    ..The mammalian kidney contributes significantly to glucose homeostasis through gluconeogenesis. Considering that stanniocalcin 1 (STC1) regulates ATP production, is synthesized and acts in different cell types of the nephron, the present ..
  72. Su J, Guo B, Zhang T, Wang K, Li X, Liang G. Stanniocalcin-1, a new biomarker of glioma progression, is associated with prognosis of patients. Tumour Biol. 2015;36:6333-9 pubmed publisher
    Stanniocalcin-1 (STC1) is a secreted glycoprotein hormone and highly expressed in various types of human malignancies...
  73. Ma X, Gu L, Li H, Gao Y, Li X, Shen D, et al. Hypoxia-induced overexpression of stanniocalcin-1 is associated with the metastasis of early stage clear cell renal cell carcinoma. J Transl Med. 2015;13:56 pubmed publisher
    ..Stanniocalcin-1 (STC1) is a glycoprotein hormone involved in calcium/phosphate homeostasis, which regulates various cellular processes in ..