STAU1

Summary

Gene Symbol: STAU1
Description: staufen double-stranded RNA binding protein 1
Alias: PPP1R150, STAU, double-stranded RNA-binding protein Staufen homolog 1, protein phosphatase 1, regulatory subunit 150, staufen, RNA binding protein, homolog 1
Species: human
Products:     STAU1

Top Publications

  1. Brendel C, Rehbein M, Kreienkamp H, Buck F, Richter D, Kindler S. Characterization of Staufen 1 ribonucleoprotein complexes. Biochem J. 2004;384:239-46 pubmed
  2. Shapira S, Gat Viks I, Shum B, Dricot A, de Grace M, Wu L, et al. A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection. Cell. 2009;139:1255-67 pubmed publisher
    ..This multilayered approach provides a comprehensive and unbiased physical and regulatory model of influenza-host interactions and demonstrates a general strategy for uncovering complex host-pathogen relationships. ..
  3. McLaren M, Marsh K, Cochrane A. Modulating HIV-1 RNA processing and utilization. Front Biosci. 2008;13:5693-707 pubmed
    ..The observations made underline the multiple fate decisions that must be made at each stage of the viral RNA metabolic pathway and highlight potential new avenues for controlling HIV-1 replication. ..
  4. Kim Y, Furic L, Parisien M, Major F, DesGroseillers L, Maquat L. Staufen1 regulates diverse classes of mammalian transcripts. EMBO J. 2007;26:2670-81 pubmed
    ..To date, Stau1 binding to the 3'-untranslated region (3'-UTR) of ADP ribosylation factor (ARF)1 mRNA has been shown to target ..
  5. Chatel Chaix L, Clément J, Martel C, Bériault V, Gatignol A, DesGroseillers L, et al. Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles. Mol Cell Biol. 2004;24:2637-48 pubmed
  6. Kretz M, Siprashvili Z, Chu C, Webster D, Zehnder A, Qu K, et al. Control of somatic tissue differentiation by the long non-coding RNA TINCR. Nature. 2013;493:231-5 pubmed publisher
    ..capacity to approximately 9,400 human recombinant proteins revealed direct binding of TINCR RNA to the staufen1 (STAU1) protein. STAU1-deficient tissue recapitulated the impaired differentiation seen with TINCR depletion...
  7. Wickham L, Duchaine T, Luo M, Nabi I, DesGroseillers L. Mammalian staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum. Mol Cell Biol. 1999;19:2220-30 pubmed
    Staufen (Stau) is a double-stranded RNA (dsRNA)-binding protein involved in mRNA transport and localization in Drosophila...
  8. Falcón A, Fortes P, Marion R, Beloso A, Ortin J. Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro. Nucleic Acids Res. 1999;27:2241-7 pubmed
    ..These results are discussed in relation to the possible mechanisms of action of hStaufen and its relevance for influenza virus infection. ..
  9. Luo M, Duchaine T, DesGroseillers L. Molecular mapping of the determinants involved in human Staufen-ribosome association. Biochem J. 2002;365:817-24 pubmed
    ..analysis on sucrose gradients, we showed that the Staufen isoform with an apparent molecular mass of 55 kDa (Stau(55)) co-fractionated with ribosomes and associated with both the 40 and 60 S ribosomal subunits, suggesting that ..

More Information

Publications95

  1. Martel C, Dugré Brisson S, Boulay K, Breton B, Lapointe G, Armando S, et al. Multimerization of Staufen1 in live cells. RNA. 2010;16:585-97 pubmed publisher
    ..In this manuscript, we provide evidence that Stau1 self-associates in live cells using immunoprecipitation and bioluminescence resonance energy transfer (BRET) ..
  2. Chatel Chaix L, Boulay K, Mouland A, DesGroseillers L. The host protein Staufen1 interacts with the Pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminus. Retrovirology. 2008;5:41 pubmed publisher
    ..We have previously shown that the double-stranded RNA-binding protein Staufen 1 (Stau1), likely through an interaction between its third double-stranded RNA-binding domain (dsRBD3) and the nucleocapsid ..
  3. Chatel Chaix L, Abrahamyan L, Fréchina C, Mouland A, DesGroseillers L. The host protein Staufen1 participates in human immunodeficiency virus type 1 assembly in live cells by influencing pr55Gag multimerization. J Virol. 2007;81:6216-30 pubmed
    ..One of these proteins, the double-stranded RNA-binding protein Staufen1 (Stau1), selectively associates with the HIV-1 genomic RNA and the viral precursor Gag protein, pr55Gag...
  4. Gong C, Maquat L. lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements. Nature. 2011;470:284-8 pubmed publisher
    Staufen 1 (STAU1)-mediated messenger RNA decay (SMD) involves the degradation of translationally active mRNAs whose 3'-untranslated regions (3' UTRs) bind to STAU1, a protein that binds to double-stranded RNA...
  5. Ravel Chapuis A, Belanger G, Yadava R, Mahadevan M, DesGroseillers L, Cote J, et al. The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicing. J Cell Biol. 2012;196:699-712 pubmed publisher
    ..Altogether, our results unravel a novel function for Staufen1 in splicing regulation and indicate that it may positively modulate the complex DM1 phenotype, thereby revealing its potential as a therapeutic target...
  6. Kim Y, Furic L, DesGroseillers L, Maquat L. Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. Cell. 2005;120:195-208 pubmed
    ..Here we describe an mRNA decay mechanism that involves Stau1, the NMD factor Upf1, and a termination codon...
  7. Cho H, Kim K, Han S, Choe J, Park S, Choi S, et al. Staufen1-mediated mRNA decay functions in adipogenesis. Mol Cell. 2012;46:495-506 pubmed publisher
    The double-stranded RNA binding protein Staufen1 (Stau1) is involved in diverse gene expression pathways...
  8. Villacé P, Marion R, Ortin J. The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. Nucleic Acids Res. 2004;32:2411-20 pubmed
    ..These results support the notion that the hStaufen-containing granules are structures essential in the localization and regulated translation of human mRNAs in vivo...
  9. de Lucas S, Oliveros J, Chagoyen M, Ortin J. Functional signature for the recognition of specific target mRNAs by human Staufen1 protein. Nucleic Acids Res. 2014;42:4516-26 pubmed publisher
    ..Our results unravel how hStau1 identifies a wide spectrum of cellular target mRNAs to control their localization, expression and fate. ..
  10. Mouland A, Mercier J, Luo M, Bernier L, DesGroseillers L, Cohen E. The double-stranded RNA-binding protein Staufen is incorporated in human immunodeficiency virus type 1: evidence for a role in genomic RNA encapsidation. J Virol. 2000;74:5441-51 pubmed
    ..This study is the first to describe hStau within HIV-1 particles and provides evidence that hStau binds HIV-1 genomic RNA, indicating that it may be implicated in retroviral genome selection and packaging into assembling virions. ..
  11. Furic L, Maher Laporte M, DesGroseillers L. A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes. RNA. 2008;14:324-35 pubmed
    ..from mRNAs isolated from immunopurified Staufen-containing complexes following transfection of HEK293T cells with Stau1(55)-HA, Stau2(59)-HA, or Stau2(62)-HA expressors...
  12. Gleghorn M, Gong C, Kielkopf C, Maquat L. Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay. Nat Struct Mol Biol. 2013;20:515-24 pubmed publisher
    Staufen1 (STAU1)-mediated mRNA decay (SMD) degrades mammalian-cell mRNAs that bind the double-stranded RNA (dsRNA)-binding protein STAU1 in their 3' untranslated region...
  13. Elbarbary R, Li W, Tian B, Maquat L. STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown. Genes Dev. 2013;27:1495-510 pubmed publisher
    ..expression by targeting mRNAs that maintain their 3' UTR IRAlus: Binding of the dsRNA-binding protein Staufen1 (STAU1) to 3' UTR IRAlus inhibits nuclear retention so as to augment the nuclear export of 3' UTR IRAlus-containing mRNAs ..
  14. de Lucas S, Peredo J, Marión R, Sanchez C, Ortin J. Human Staufen1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus multiplication. J Virol. 2010;84:7603-12 pubmed publisher
    ..These results indicate a role for hStau1 in late events of the influenza virus infection, possibly during virus morphogenesis. ..
  15. Abrahamyan L, Chatel Chaix L, Ajamian L, Milev M, Monette A, Clément J, et al. Novel Staufen1 ribonucleoproteins prevent formation of stress granules but favour encapsidation of HIV-1 genomic RNA. J Cell Sci. 2010;123:369-83 pubmed publisher
    ..This work provides new evidence that Staufen1-containing HIV-1 RNPs preferentially form over other cellular silencing foci and are involved in assembly, localization and encapsidation of vRNA...
  16. Marion R, Fortes P, Beloso A, Dotti C, Ortin J. A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum. Mol Cell Biol. 1999;19:2212-9 pubmed
    ..Furthermore, sedimentation analyses indicated that hStaufen-like protein associates with polysomes. These results are discussed in relation to the possible functions of the protein...
  17. Shetty A, Venkatesh T, Tsutsumi R, Suresh P. Regulated expression of Gemin5, Xrn1, Cpeb and Stau1 in the uterus and ovaries after superovulation and the effect of exogenous estradiol and leptin in rodents. Mol Biol Rep. 2019;46:2533-2540 pubmed publisher
    The aim of this study was to evaluate whether Gemin 5, Cpeb, Xrn1, and Stau1 expression in rodent ovaries and uterine tissues is dependent on gonadotropins, steroid hormones, and leptin in the superovulation and ovariectomized mouse ..
  18. Fang J, Pietzsch C, Ramanathan P, Santos R, Ilinykh P, Garcia Blanco M, et al. Staufen1 Interacts with Multiple Components of the Ebola Virus Ribonucleoprotein and Enhances Viral RNA Synthesis. MBio. 2018;9: pubmed publisher
    ..proteins that bind to EBOV RNAs and identified four high-confidence proviral host factors, including Staufen1 (STAU1), which specifically binds both 3' and 5' extracistronic regions of the EBOV genome...
  19. Damas N, Marcatti M, Come C, Christensen L, Nielsen M, Baumgartner R, et al. SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization. Nat Commun. 2016;7:13875 pubmed publisher
    ..Mechanistically, we suggest that SNHG5 stabilizes the target transcripts by blocking their degradation by STAU1. Accordingly, depletion of STAU1 rescues the apoptosis induced after SNHG5 knockdown...
  20. Hohn O, Hanke K, Lausch V, Zimmermann A, Mostafa S, Bannert N. CMV-promoter driven codon-optimized expression alters the assembly type and morphology of a reconstituted HERV-K(HML-2). Viruses. 2014;6:4332-45 pubmed publisher
    ..Overexpression permitted the release and maturation of virions but reduced the envelope content. A weaker boost of virus expression by Staufen-1 was not sufficient to induce these morphological alterations. ..
  21. Kim Y, Maquat L. UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond. RNA. 2019;: pubmed publisher
    ..UPF1, as a protein polymath, engenders cells with the ability to shape their transcriptome in response to diverse biological and physiological needs. ..
  22. Maekawa S, Imamachi N, Irie T, Tani H, Matsumoto K, Mizutani R, et al. Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance. BMC Genomics. 2015;16:154 pubmed publisher
    ..We identified UPF1, EXOSC5 and STAU1, well-studied RNA degradation factors, as controlling factors for 8% of cases...
  23. Chang C, Nashchekin D, Wheatley L, Irion U, Dahlgaard K, Montague T, et al. Anterior-posterior axis specification in Drosophila oocytes: identification of novel bicoid and oskar mRNA localization factors. Genetics. 2011;188:883-96 pubmed publisher
  24. Xu T, Wang Y, Xiong W, Ma P, Wang W, Chen W, et al. E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis. Cell Death Dis. 2017;8:e2837 pubmed publisher
    ..TINCR could bind to STAU1 (staufen1) protein, and influence CDKN2B mRNA stability and expression, thereby affecting the proliferation of GC ..
  25. Ravel Chapuis A, Crawford T, Blais Crépeau M, Bélanger G, Richer C, Jasmin B. The RNA-binding protein Staufen1 impairs myogenic differentiation via a c-myc-dependent mechanism. Mol Biol Cell. 2014;25:3765-78 pubmed publisher
  26. Ravanidis S, Kattan F, Doxakis E. Unraveling the Pathways to Neuronal Homeostasis and Disease: Mechanistic Insights into the Role of RNA-Binding Proteins and Associated Factors. Int J Mol Sci. 2018;19: pubmed publisher
  27. Lucas B, Lavi E, Shiue L, Cho H, Katzman S, Miyoshi K, et al. Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay. Proc Natl Acad Sci U S A. 2018;115:968-973 pubmed publisher
    ..regulated by SMD, by measuring changes in mRNA abundance after individual depletion of two SMD factors, Staufen1 (STAU1) and UPF1, in both human and mouse myoblasts...
  28. Wang X, Vuković L, Koh H, Schulten K, Myong S. Dynamic profiling of double-stranded RNA binding proteins. Nucleic Acids Res. 2015;43:7566-76 pubmed publisher
    ..Collectively, our study highlights the diverse nature of substrate specificity and mobility exhibited by dsRBPs that may be critical for their cellular function. ..
  29. Cao L, Liang Y, Liu Y, Xu Y, Wan W, Zhu C. Pseudo-phosphorylation at AT8 epitopes regulates the tau truncation at aspartate 421. Exp Cell Res. 2018;370:103-115 pubmed publisher
    ..In current study, staurosporine (Stau) induced ?Tau generation by caspases in SH-SY5Y cells with tau overexpression was found to be accompanied by a ..
  30. Peng L, Zhang H, Su Y, Shen Q, Du C, Xie H, et al. Lipopolysaccharide enhances ADAR2 which drives Hirschsprung's disease by impairing miR-142-3p biogenesis. J Cell Mol Med. 2018;22:4045-4055 pubmed publisher
    ..combined with qRT-PCR suggested that ADAR2 restrain cell migration and proliferation via pri-miR-142 editing and STAU1 up-regulation...
  31. Xu T, Liu X, Xia R, Yin L, Kong R, Chen W, et al. SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer. Oncogene. 2015;34:5648-61 pubmed publisher
    ..Mechanistic analyses indicated that TINCR could bind to STAU1 (staufen1) protein, and influence KLF2 mRNA stability and expression, then KLF2 regulated cyclin-dependent kinase ..
  32. Thomas M, Martinez Tosar L, Loschi M, Pasquini J, Correale J, Kindler S, et al. Staufen recruitment into stress granules does not affect early mRNA transport in oligodendrocytes. Mol Biol Cell. 2005;16:405-20 pubmed
  33. Sellars M, Trewin C, McWilliam S, Glaves R, Hertzler P. Transcriptome profiles of Penaeus (Marsupenaeus) japonicus animal and vegetal half-embryos: identification of sex determination, germ line, mesoderm, and other developmental genes. Mar Biotechnol (NY). 2015;17:252-65 pubmed publisher
    ..Genes expressed only in the animal half included bmp1, kruppel, maelstrom, and orthodenticle. Genes expressed only in the vegetal half included boule, brachyury, deformed, dorsal, engrailed, hunchback, spalt, twist, and wingless/wnt-8c. ..
  34. Liu Z, Chen Z, Fan R, Jiang B, Chen X, Chen Q, et al. Over-expressed long noncoding RNA HOXA11-AS promotes cell cycle progression and metastasis in gastric cancer. Mol Cancer. 2017;16:82 pubmed publisher
    ..transcription, bind with EZH2 and repress P21 transcription, and induce KLF2 mRNA degradation via interacting with STAU1. Taken together, these findings show that HOXA11-AS not only could promote GC cells migration and invasion in ..
  35. Lachke S, Alkuraya F, Kneeland S, Ohn T, Aboukhalil A, Howell G, et al. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011;331:1571-6 pubmed publisher
    ..a Tudor domain RNA binding protein that is expressed in lens fiber cells in distinct TDRD7-RGs that interact with STAU1-ribonucleoproteins (RNPs)...
  36. Popper B, Demleitner A, Bolivar V, KUSEK G, Snyder Keller A, Schieweck R, et al. Staufen2 deficiency leads to impaired response to novelty in mice. Neurobiol Learn Mem. 2018;150:107-115 pubmed publisher
    ..Together, our data suggest that Stau2 contributes to novelty preference and explorative behavior that is a driver for proper spatial learning in mice. ..
  37. Yu Y, Li Y, Zhang Y. Screening of APP interaction proteins by DUALmembrane yeast two-hybrid system. Int J Clin Exp Pathol. 2015;8:2802-8 pubmed
    ..APP functions through protein-protein interactions, and in this report staufen 1 (STAU1) is demonstrated to have interaction with APP, using yeast two-hybrid screening and co-immunoprecipitation in ..
  38. Ren Z, Veksler Lublinsky I, Morrissey D, Ambros V. Staufen Negatively Modulates MicroRNA Activity in Caenorhabditis elegans. G3 (Bethesda). 2016;6:1227-37 pubmed publisher
    ..Here, we demonstrate that the Caenorhabditis elegans homolog of Staufen, STAU-1, functionally interacts with microRNAs...
  39. Jia M, Shan Z, Yang Y, Liu C, Li J, Luo Z, et al. The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division. Nat Commun. 2015;6:8381 pubmed publisher
    ..the scaffold Miranda (Mira) coordinates the subcellular distribution of cell-fate determinants including Staufen (Stau) and segregates them into the ganglion mother cells (GMCs)...
  40. Yang C, Chen Y, Chang Y, Liu H, Kuo Y, Shih C, et al. ADAR1-mediated 3' UTR editing and expression control of antiapoptosis genes fine-tunes cellular apoptosis response. Cell Death Dis. 2017;8:e2833 pubmed publisher
    ..Rather, we discovered that ADAR1 competes transcript occupancy with the RNA shuttling factor STAU1 to facilitate nuclear retention of the XIAP and MDM2 mRNAs...
  41. Moon B, Bai J, Cai M, Liu C, Shi J, Lu W. Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis. Nat Commun. 2018;9:401 pubmed publisher
    ..In addition, Klf4 interacts with RNA-binding protein Staufen1 (Stau1) and RNA helicase Ddx5/17. They function together as a complex to maintain NPC self-renewal...
  42. Dixit U, Pandey A, Mishra P, Sengupta A, Pandey V. Staufen1 promotes HCV replication by inhibiting protein kinase R and transporting viral RNA to the site of translation and replication in the cells. Nucleic Acids Res. 2016;44:5271-87 pubmed publisher
    ..We have identified a cytoplasmic double-stranded RNA binding protein, Stau1, which is crucial for HCV replication...
  43. Gleeson J, Lederman R, Herrman H, Koval P, Eleftheriadis D, Bendall S, et al. Moderated online social therapy for carers of young people recovering from first-episode psychosis: study protocol for a randomised controlled trial. Trials. 2017;18:27 pubmed publisher
    ..The two treatment conditions include Altitudes plus Specialist Treatment as Usual (STAU) and STAU alone...
  44. Macchi P, Kroening S, Palacios I, Baldassa S, Grunewald B, Ambrosino C, et al. Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner. J Neurosci. 2003;23:5778-88 pubmed
    ..Together, our data suggest that the mRNA transport machinery is conserved during evolution, and that mammalian Btz is an additional component of the dendritic RNPs in hippocampal neurons. ..
  45. Lee J, Oh J, Pascua P, Kim E, Choi Y, Kim H. Impairment of the Staufen1-NS1 interaction reduces influenza viral replication. Biochem Biophys Res Commun. 2011;414:153-8 pubmed publisher
    Staufen1 (Stau1), a host cellular protein, along with non-structural protein 1 (NS1), an influenza viral protein, associate with each other during influenza viral infection and down-regulation of Stau1 by RNA interference reduces the ..
  46. Milev M, Brown C, Mouland A. Live cell visualization of the interactions between HIV-1 Gag and the cellular RNA-binding protein Staufen1. Retrovirology. 2010;7:41 pubmed publisher
    ..The present work characterizes the interaction sites of key components of the HIV-1 RNP (Gag, Staufen1 and IMP1), thereby bringing to light where HIV-1 recruits and co-opts RNA-binding proteins during virus assembly. ..
  47. Hanke K, Hohn O, Liedgens L, Fiddeke K, Wamara J, Kurth R, et al. Staufen-1 interacts with the human endogenous retrovirus family HERV-K(HML-2) rec and gag proteins and increases virion production. J Virol. 2013;87:11019-30 pubmed publisher
    ..Our results suggest a new role for Staufen-1 as a cellular Rec and HERV-K(HML-2) Gag cofactor. ..
  48. Hohn O, Mostafa S, Norley S, Bannert N. Development of an antigen-capture ELISA for the detection of the p27-CA protein of HERV-K(HML-2). J Virol Methods. 2016;234:186-92 pubmed publisher
  49. Cho H, Han S, Park O, Kim Y. SMG1 regulates adipogenesis via targeting of staufen1-mediated mRNA decay. Biochim Biophys Acta. 2013;1829:1276-87 pubmed publisher
    ..Upf1 is also known to be involved in staufen 1 (Stau1)-mediated mRNA decay (SMD), which is closely related to NMD...
  50. Sugimoto Y, Vigilante A, Darbo E, Zirra A, Militti C, D Ambrogio A, et al. hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1. Nature. 2015;519:491-4 pubmed publisher
    ..Using this technique to investigate RNA structures bound by Staufen 1 (STAU1) in human cells, we uncover a dominance of intra-molecular RNA duplexes, a depletion of duplexes from coding ..
  51. DesGroseillers L, Lemieux N. Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization. Genomics. 1996;36:527-9 pubmed
    ..characterize its components, we recently cloned and sequenced the human staufen homolog cDNA (HGMW-approved symbol STAU)...
  52. Bonnet Magnaval F, Philippe C, Van den Berghe L, Prats H, Touriol C, Lacazette E. Hypoxia and ER stress promote Staufen1 expression through an alternative translation mechanism. Biochem Biophys Res Commun. 2016;479:365-371 pubmed publisher
    ..Staufen 1 (Stau1) is an RNA-binding protein that has been previously implicated in the regulation of stress granule formation and ..
  53. Wang L, Fu B, Li W, Patil G, Liu L, Dorf M, et al. Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction. Nat Commun. 2017;8:13876 pubmed publisher
    ..Taken together, comparative analyses of the influenza-host protein interactomes identified PKP2 as a natural inhibitor of IAV polymerase complex. ..
  54. Oh Y, Park J, Kim J, Chang M, Lee S, Cho Y, et al. Lin28B and miR-142-3p regulate neuronal differentiation by modulating Staufen1 expression. Cell Death Differ. 2018;25:432-443 pubmed publisher
    Staufen1 (STAU1) and Lin28B are RNA-binding proteins that are involved in neuronal differentiation as a function of post-transcriptional regulation...
  55. Lingappa J, Reed J, Tanaka M, Chutiraka K, Robinson B. How HIV-1 Gag assembles in cells: Putting together pieces of the puzzle. Virus Res. 2014;193:89-107 pubmed publisher
    ..Overall, we show how data obtained using a variety of techniques has led to our current understanding of HIV assembly. ..
  56. Cho H, Park O, Park J, Ryu I, Kim J, Ko J, et al. Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation. Proc Natl Acad Sci U S A. 2015;112:E1540-9 pubmed publisher
    ..Thus, our data provide molecular evidence of a posttranscriptional role of the well-studied nuclear hormone receptor, GR, which is traditionally considered a transcription factor. ..
  57. Fa Hui N, Hai Feng Y, Rui Feng Q, Xin L, Cai Bin W. Characterization of a novel transcript variant of human STAU1 gene. Acta Biochim Pol. 2008;55:473-8 pubmed
    Human STAU1 is one member of the family of double-stranded RNA (dsRNA)-binding proteins...
  58. Yu Z, Fan D, Gui B, Shi L, Xuan C, Shan L, et al. Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells. J Biol Chem. 2012;287:22560-72 pubmed publisher
    ..Here, we report that TDP-43 is physically associated with fragile X mental retardation protein (FMRP) and Staufen (STAU1) to form a functional complex...
  59. Angenstein F, Evans A, Settlage R, Moran S, Ling S, Klintsova A, et al. A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. J Neurosci. 2002;22:8827-37 pubmed
  60. Neppl R, Wu C, Walsh K. lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy. J Cell Biol. 2017;216:3497-3507 pubmed publisher
    ..Inhibition of Chronos induces myofiber hypertrophy both in vitro and in vivo, in part, through the epigenetic modulation of Bmp7 signaling. ..
  61. Park E, Gleghorn M, Maquat L. Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. Proc Natl Acad Sci U S A. 2013;110:405-12 pubmed publisher
    ..mRNA decay (SMD) is a posttranscriptional regulatory mechanism in mammals that degrades mRNAs harboring a STAU1-binding site (SBS) in their 3'-untranslated regions (3' UTRs)...
  62. de Chassey B, Aublin Gex A, Ruggieri A, Meyniel Schicklin L, Pradezynski F, Davoust N, et al. The interactomes of influenza virus NS1 and NS2 proteins identify new host factors and provide insights for ADAR1 playing a supportive role in virus replication. PLoS Pathog. 2013;9:e1003440 pubmed publisher
    ..ADAR1 editing activity was enhanced by both viruses through dengue virus NS3 and influenza virus NS1 proteins, suggesting a similar virus-host co-evolution. ..
  63. Ghoujal B, Milev M, Ajamian L, Abel K, Mouland A. ESCRT-II's involvement in HIV-1 genomic RNA trafficking and assembly. Biol Cell. 2012;104:706-21 pubmed publisher
    ..Our data provide the first evidence that the Staufen1-ESCRT-II interaction is evolutionarily conserved from lower to higher eukaryotes and reveal a novel role for EAP30 in the control of HIV-1 RNA trafficking and gene expression...
  64. Toro Ascuy D, Rojas Araya B, Valiente Echeverría F, Soto Rifo R. Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries. Viruses. 2016;8: pubmed
    ..decay pathways such as up-frameshift suppressor 1 homolog (UPF1), Staufen double-stranded RNA binding protein 1/2 (STAU1/2), or components of miRNA-induced silencing complex (miRISC) and processing bodies (PBs)...
  65. Kiebler M, DesGroseillers L. Molecular insights into mRNA transport and local translation in the mammalian nervous system. Neuron. 2000;25:19-28 pubmed
  66. Peredo J, Villacé P, Ortín J, de Lucas S. Human Staufen1 associates to miRNAs involved in neuronal cell differentiation and is required for correct dendritic formation. PLoS ONE. 2014;9:e113704 pubmed publisher
  67. De Santis L, Gandolfi F, Pennarossa G, Maffei S, Gismano E, Intra G, et al. Expression and intracytoplasmic distribution of staufen and calreticulin in maturing human oocytes. J Assist Reprod Genet. 2015;32:645-52 pubmed publisher
    ..We assessed the expression of staufen (STAU) and calreticulin (CALR), the latter adopted as a marker of the endoplasmic reticulum, in human oocytes at ..
  68. Mori M, Kovalenko L, Lyonnais S, Antaki D, Torbett B, Botta M, et al. Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1. Curr Top Microbiol Immunol. 2015;389:53-92 pubmed publisher
    ..Though the antiviral activity of the identified NCIs needs still to be improved, these compounds strongly support the druggability of NC and pave the way for future structure-based design and optimization of efficient NCIs. ..
  69. Imamachi N, Tani H, Akimitsu N. Up-frameshift protein 1 (UPF1): multitalented entertainer in RNA decay. Drug Discov Ther. 2012;6:55-61 pubmed
    ..Moreover UPF1 is not only a key player in NMD but is also involved in non-NMD RNA degradation, such as staufen1 (STAU1)-mediated mRNA decay (SMD) and replication-dependent histone mRNA decay...
  70. Tretyakova I, Zolotukhin A, Tan W, Bear J, Propst F, Ruthel G, et al. Nuclear export factor family protein participates in cytoplasmic mRNA trafficking. J Biol Chem. 2005;280:31981-90 pubmed
    ..We propose a model in which MAP1B tethers the NXF-associated mRNA to microtubules and facilitates their translocation along dendrites while Unrip provides a scaffold for the assembly of these transport intermediates. ..
  71. Meng B, Lever A. Wrapping up the bad news: HIV assembly and release. Retrovirology. 2013;10:5 pubmed publisher
  72. Weidensdorfer D, Stöhr N, Baude A, Lederer M, Köhn M, Schierhorn A, et al. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. RNA. 2009;15:104-15 pubmed publisher
    ..Complex formation at the CRD presumably limits the transfer of c-myc mRNA to the polysomal fraction and subsequent translation-coupled decay. ..
  73. Zencir S, Banerjee M, Dobson M, Ayaydin F, Fodor E, Topcu Z, et al. New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP). Biochem Biophys Res Commun. 2013;432:10-5 pubmed publisher
    ..Here, we report the identification by yeast two-hybrid screening of two new hGIP-interacting partners, DTX1 and STAU1. Both proteins lack the typical C-terminal PDZ recognition motif but contain a novel internal hGIP recognition ..
  74. Cho H, Ahn S, Kim K, Kim Y. Non-structural protein 1 of influenza viruses inhibits rapid mRNA degradation mediated by double-stranded RNA-binding protein, staufen1. FEBS Lett. 2013;587:2118-24 pubmed publisher
    ..In particular, NS1 is known to interact with the host protein, staufen1 (Stau1). This interaction is important for efficient viral replication...
  75. Sakurai M, Shiromoto Y, Ota H, Song C, Kossenkov A, Wickramasinghe J, et al. ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay. Nat Struct Mol Biol. 2017;24:534-543 pubmed publisher
    ..Our study reveals a new stress-response mechanism in which human ADAR1p110 and Staufen1 regulate surveillance of a set of mRNAs required for survival of stressed cells. ..
  76. Ohashi S, Koike K, Omori A, Ichinose S, Ohara S, Kobayashi S, et al. Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor. J Biol Chem. 2002;277:37804-10 pubmed
  77. Blackham S, McGarvey M. A host cell RNA-binding protein, Staufen1, has a role in hepatitis C virus replication before virus assembly. J Gen Virol. 2013;94:2429-36 pubmed publisher
    ..g. in translation, replication or trafficking of the HCV genome, rather than in virion morphogenesis. ..
  78. Gong C, Tang Y, Maquat L. mRNA-mRNA duplexes that autoelicit Staufen1-mediated mRNA decay. Nat Struct Mol Biol. 2013;20:1214-20 pubmed publisher
    ..with a partially complementary Alu element in the 3' UTR of a different mRNA, thereby creating a Staufen1 (STAU1)-binding site (SBS)...
  79. Lin Z, Tan C, Qiu Q, Kong S, Yang H, Zhao F, et al. Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1. Cell Discov. 2015;1: pubmed
    ..Our study demonstrates that USP22 is a CCNB1 deubiquitinase, suggesting that targeting USP22 might be an effective approach to treat cancers with elevated CCNB1 expression. ..
  80. Tiwari B, Kurtz P, Jones A, Wylie A, Amatruda J, Boggupalli D, et al. Retrotransposons Mimic Germ Plasm Determinants to Promote Transgenerational Inheritance. Curr Biol. 2017;27:3010-3016.e3 pubmed publisher
    ..Together, these results suggest that germ plasm targeting represents a fitness strategy adopted by some retrotransposons to ensure transgenerational propagation. ..
  81. Scott D, Trahan C, Zindy P, Aguilar L, Delubac M, Van Nostrand E, et al. Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism. Nucleic Acids Res. 2017;45:12509-12528 pubmed publisher
    ..Identification of a complex Nol12 interactome, which includes NONO, Dhx9, DNA-PK and Stau1, further supports the protein's diverse functions in RNA metabolism and DNA maintenance, establishing Nol12 as a ..
  82. Kretz M. TINCR, staufen1, and cellular differentiation. RNA Biol. 2013;10:1597-601 pubmed publisher
    ..We consider a role for TINCR as an epithelial-specific guide for targeting the Staufen1 protein to specific mRNAs, reflecting the increasing complexity of gene regulatory processes in mammalian cells and tissue. ..
  83. Monshausen M, Rehbein M, Richter D, Kindler S. The RNA-binding protein Staufen from rat brain interacts with protein phosphatase-1. J Neurochem. 2002;81:557-64 pubmed
    ..Cellular functions of Staufen may be regulated via phosphorylation or Staufen may recruite the phosphatase into specific ribonucleoprotein complexes. ..
  84. Hosoda N, Kim Y, Lejeune F, Maquat L. CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells. Nat Struct Mol Biol. 2005;12:893-901 pubmed
    ..Here, we provide evidence that CBP80 augments the efficiency of NMD but not of Staufen1 (Stau1)-mediated mRNA decay (SMD)...
  85. Mick E, McGough J, Deutsch C, Frazier J, Kennedy D, Goldberg R. Genome-wide association study of proneness to anger. PLoS ONE. 2014;9:e87257 pubmed publisher
    ..These results suggest that signaling pathways regulating intracellular calcium homeostasis, which are relevant to memory, learning, and neuronal survival, may in part underlie the expression of Angry Temperament. ..
  86. Bondy Chorney E, Crawford Parks T, Ravel Chapuis A, Klinck R, Rocheleau L, Pelchat M, et al. Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier. PLoS Genet. 2016;12:e1005827 pubmed publisher
    ..Previously, we showed that the multi-functional RNA-binding protein Staufen1 (Stau1) was increased in skeletal muscle of DM1 mouse models and patients...