STAT6

Summary

Gene Symbol: STAT6
Description: signal transducer and activator of transcription 6
Alias: D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 6, STAT, interleukin4-induced, signal transducer and activator of transcription 6, interleukin-4 induced, transcription factor IL-4 STAT
Species: human
Products:     STAT6

Top Publications

  1. Shimoda K, van Deursen J, Sangster M, Sarawar S, Carson R, Tripp R, et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. 1996;380:630-3 pubmed
    ..b>Stat6 is activated in response to interleukin (IL)-4 and may contribute to various functions including mitogenesis, T-..
  2. Velavan T, Bechlars S, Tomiuk J, Kremsner P, Kun J. Molecular characterization of regulatory polymorphisms in the promoter region of the STAT6 gene in a Gabonese population. Mem Inst Oswaldo Cruz. 2011;106:65-9 pubmed
    ..We focussed on signal transducer and activator of transcription (STAT6) factor that plays a fundamental role in signal transduction and activation of transcription...
  3. Granada M, Wilk J, Tuzova M, Strachan D, Weidinger S, Albrecht E, et al. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. J Allergy Clin Immunol. 2012;129:840-845.e21 pubmed publisher
    ..Thirteen SNPs located in the region of 3 genes, FCER1A, signal transducer and activator of transcription 6 (STAT6), and IL13, were found to have genome-wide significance in the FHS cohort GWAS...
  4. He H, Isnard A, Kouriba B, Cabantous S, Dessein A, Doumbo O, et al. A STAT6 gene polymorphism is associated with high infection levels in urinary schistosomiasis. Genes Immun. 2008;9:195-206 pubmed publisher
    ..By logistic regression analysis, we found an association between a single-nucleotide polymorphism (SNP) in the STAT6 gene (rs324013) and infection levels (P=0.04)...
  5. Elo L, Jarvenpaa H, Tuomela S, Raghav S, Ahlfors H, Laurila K, et al. Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming. Immunity. 2010;32:852-62 pubmed publisher
    ..Because the STAT6 transcription factor is an upstream mediator required for interleukin-4 (IL-4)-induced Th2 cell differentiation, ..
  6. Yu H, Liu P, Lin Y, Chen W, Lee J, Wang L, et al. Interleukin 4 and STAT6 gene polymorphisms are associated with systemic lupus erythematosus in Chinese patients. Lupus. 2010;19:1219-28 pubmed publisher
    ..A borderline significant three-locus gene-gene interaction among IL4 9241 C/G, IL4 -33 T/C, signal transducer and activator of transcription 6, IL4-induced (STAT6) 2892 C/T was detected by a multifactor dimensionality reduction test (p ..
  7. Zhang W, Li B, Yang X, Li P, Yuan Q, Liu X, et al. IL-4-induced Stat6 activities affect apoptosis and gene expression in breast cancer cells. Cytokine. 2008;42:39-47 pubmed publisher
    IL-4-induced Stat6 signaling is active in a variety of cell types, including immune cells and cancer cells, and plays an important role in the regulation of gene expression...
  8. Das S, Roth C, Wasson L, Vishwanatha J. Signal transducer and activator of transcription-6 (STAT6) is a constitutively expressed survival factor in human prostate cancer. Prostate. 2007;67:1550-64 pubmed
    ..In this investigation, we examined STAT6 expression in clinical prostate cancer tissue specimen and determined its role in prostate cell proliferation and ..
  9. Litterst C, Pfitzner E. An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1. J Biol Chem. 2002;277:36052-60 pubmed
    b>Signal transducer and activator of transcription 6 (STAT6) regulates transcriptional activation in response to interleukin-4 (IL-4)-induced tyrosine phosphorylation by direct interaction with coactivators...

More Information

Publications85

  1. Merk B, Owens J, Lopes M, Silva C, Hussaini I. STAT6 expression in glioblastoma promotes invasive growth. BMC Cancer. 2011;11:184 pubmed publisher
    ..b>STAT6 protein expression was analyzed by Western blotting in GBM cell lines and by immunohistochemistry in a tissue ..
  2. Li B, Yang X, Li P, Yuan Q, Liu X, Yuan J, et al. IL-4/Stat6 activities correlate with apoptosis and metastasis in colon cancer cells. Biochem Biophys Res Commun. 2008;369:554-60 pubmed publisher
    IL-4-induced Stat6 signaling is active in a variety of cell types and plays a role in cell proliferation/growth and resistance to apoptosis...
  3. Chmielecki J, Crago A, Rosenberg M, O Connor R, Walker S, Ambrogio L, et al. Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nat Genet. 2013;45:131-2 pubmed publisher
    Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs...
  4. Schweizer L, Koelsche C, Sahm F, Piro R, Capper D, Reuss D, et al. Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. Acta Neuropathol. 2013;125:651-8 pubmed publisher
    ..Recent detection of frequent NAB2-STAT6 fusions in both, HPC and SFT, provided additional support for this view...
  5. Galka E, Thompson J, Zhang W, Poritz L, Koltun W. Stat6(null phenotype) human lymphocytes exhibit increased apoptosis. J Surg Res. 2004;122:14-20 pubmed
    ..These proinflammatory events may result from dysfunctional IL-4/Stat6 signal transduction that normally promotes Th2 lymphocyte differentiation and consequential down-regulation of the ..
  6. Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, et al. Essential role of Stat6 in IL-4 signalling. Nature. 1996;380:627-30 pubmed
    ..IL-4 activates two distinct signalling pathways through tyrosine phosphorylation of Stat6, a signal transducer and activator of transcription, and of a 170K protein called 4PS...
  7. Patel B, Keck C, O Leary R, Popescu N, LaRochelle W. Localization of the human stat6 gene to chromosome 12q13.3-q14.1, a region implicated in multiple solid tumors. Genomics. 1998;52:192-200 pubmed
    b>Stat6 signaling pathways have been correlated with functional responses induced by IL-4 and PDGF that may play a role in human malignancy...
  8. Peisong G, Yamasaki A, Mao X, Enomoto T, Feng Z, Gloria Bottini F, et al. An asthma-associated genetic variant of STAT6 predicts low burden of ascaris worm infestation. Genes Immun. 2004;5:58-62 pubmed
    ..a common genetic variant of the 3'-UTR regulatory elements of the signal transducer and transactivating factor (STAT6) (P=0.0002) and egg counts, at the 77 th centile...
  9. Shankaranarayanan P, Chaitidis P, Kuhn H, Nigam S. Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene. J Biol Chem. 2001;276:42753-60 pubmed
    ..15-lipoxygenase-1 (15-LOX-1) in various mammalian cells via the Janus kinase/signal transducer and activator of transcription 6 (STAT6) signaling system...
  10. Wang Q, Bai X, Xu D, Li H, Xu C, Fang J. Association of polymorphisms of STAT6 and SO(2) with Chinese childhood asthma: a case-control study. Biomed Environ Sci. 2011;24:670-7 pubmed publisher
    To investigate the association of polymorphisms of STAT6 gene and air pollutants of PM(10), NO(2), and SO(2), with asthma in Chinese children. 418 subjects aged 14 years and under were recruited in a case-control study...
  11. Wei M, Liu B, Gu Q, Su L, Yu Y, Zhu Z. Stat6 cooperates with Sp1 in controlling breast cancer cell proliferation by modulating the expression of p21(Cip1/WAF1) and p27 (Kip1). Cell Oncol (Dordr). 2013;36:79-93 pubmed publisher
    The signal transducer and activator of transcription 6 (Stat6), a member of the family of DNA-binding proteins, has been identified as a critical cell differentiation modulator in breast cancer cells...
  12. Duetsch G, Illig T, Loesgen S, Rohde K, Klopp N, Herbon N, et al. STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sib-pair study. Hum Mol Genet. 2002;11:613-21 pubmed
    The human signal transducer and activator of transcription 6 (STAT6) gene represents one of the most promising candidate genes for asthma and other inflammatory diseases on the chromosomal region 12q13-q24...
  13. Li Y, Wu B, Xiong H, Zhu C, Zhang L. Polymorphisms of STAT-6, STAT-4 and IFN-gamma genes and the risk of asthma in Chinese population. Respir Med. 2007;101:1977-81 pubmed
    ..In addition, the significant interactions among STAT-6 G2964A, STAT-4 T90089C and IFN-gamma T874A may increase an individual's susceptibility and contribute to the pathogenesis of asthma. ..
  14. Mikita T, Daniel C, Wu P, Schindler U. Mutational analysis of the STAT6 SH2 domain. J Biol Chem. 1998;273:17634-42 pubmed
    ..STAT protein that mediate these various interactions, we have carried out an extensive mutational analysis of the Stat6 SH2 domain...
  15. Zhang M, Zhou Y, Xie C, Zhou F, Chen Y, Han G, et al. STAT6 specific shRNA inhibits proliferation and induces apoptosis in colon cancer HT-29 cells. Cancer Lett. 2006;243:38-46 pubmed
    ..we have demonstrated that different short hairpin RNAs (shRNAs) can specifically knock-down the transcription of STAT6, resulting in the inhibition of cell proliferation, G1/S phase arrest and apoptotic death in colon cancer HT-29 ..
  16. Tamura K, Suzuki M, Arakawa H, Tokuyama K, Morikawa A. Linkage and association studies of STAT6 gene polymorphisms and allergic diseases. Int Arch Allergy Immunol. 2003;131:33-8 pubmed
    b>Signal transducer and activator of transcription 6 (STAT6) is a key transcription factor involved in both interleukin-4 (IL-4) and IL-13-mediated biological responses, such as allergies...
  17. Razeto A, Ramakrishnan V, Litterst C, Giller K, Griesinger C, Carlomagno T, et al. Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. J Mol Biol. 2004;336:319-29 pubmed
    b>Signal transducer and activator of transcription 6 (STAT6) regulates transcriptional activation in response to interleukin-4 (IL-4) by direct interaction with coactivators...
  18. Chen H, Sun H, You F, Sun W, Zhou X, Chen L, et al. Activation of STAT6 by STING is critical for antiviral innate immunity. Cell. 2011;147:436-46 pubmed publisher
    b>STAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune signaling in response to virus infection...
  19. Kelly Welch A, Hanson E, Boothby M, Keegan A. Interleukin-4 and interleukin-13 signaling connections maps. Science. 2003;300:1527-8 pubmed
    ..In addition, stimulation of the phosphatidylinositol 3-kinase (PI3K) pathway through recruitment of members of the insulin receptor substrate family may contribute to survival and proliferation. ..
  20. Weidinger S, Klopp N, Wagenpfeil S, Rummler L, Schedel M, Kabesch M, et al. Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults. J Med Genet. 2004;41:658-63 pubmed
    ..Among candidate genes in this region is STAT6 (signal transducer and activator of transcription), which is essential for Th2 cell differentiation, recruitment, ..
  21. Wei L, Vahedi G, Sun H, Watford W, Takatori H, Ramos H, et al. Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity. 2010;32:840-51 pubmed publisher
    Signal transducer and activator of transcription 4 (STAT4) and STAT6 are key factors in the specification of helper T cells; however, their direct roles in driving differentiation are not well understood...
  22. Dubey R, Chhabra R, Saini N. Small interfering RNA against transcription factor STAT6 leads to increased cholesterol synthesis in lung cancer cell lines. PLoS ONE. 2011;6:e28509 pubmed publisher
    b>STAT6 transcription factor has become a potential molecule for therapeutic intervention because it regulates broad range of cellular processes in a large variety of cell types...
  23. Ahn H, Kim J, Ryu K, Nam H. STAT6 activation by Toxoplasma gondii infection induces the expression of Th2 C-C chemokine ligands and B clade serine protease inhibitors in macrophage. Parasitol Res. 2009;105:1445-53 pubmed publisher
    ..Phosphorylation of STAT6 occurred immediately after the entry of T. gondii and only by live tachyzoites, not by killed or soluble extract...
  24. Guiter C, Dusanter Fourt I, Copie Bergman C, Boulland M, le Gouvello S, Gaulard P, et al. Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma. Blood. 2004;104:543-9 pubmed
    ..We therefore investigated the functional state of the signal transducer and activator of transcription 6 (STAT6), mediating IL-4/IL-13 transcriptional effects...
  25. Chiba Y, Todoroki M, Nishida Y, Tanabe M, Misawa M. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am J Respir Cell Mol Biol. 2009;41:516-24 pubmed publisher
    ..The signal transducer and activation of transcription 6 (STAT6) is one of the major signal transducers activated by IL-13, and a possible involvement of IL-13/STAT6 pathway in ..
  26. Litterst C, Pfitzner E. Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. J Biol Chem. 2001;276:45713-21 pubmed
    b>Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression...
  27. Wurster A, Rodgers V, White M, Rothstein T, Grusby M. Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. J Biol Chem. 2002;277:27169-75 pubmed
    ..b>Stat6 is rapidly activated after IL-4 stimulation, but its role in B lymphocyte apoptosis has not been explored...
  28. Kim Y, Kwon E, Jeon J, So I, Kim I, Choi M, et al. Activation of the STAT6 transcription factor in Jurkat T-cells by the herpesvirus saimiri Tip protein. J Gen Virol. 2012;93:330-40 pubmed publisher
    ..In this study, we found that Tip interacts with the STAT6 transcription factor and induces phosphorylation of STAT6 in T-cells...
  29. Robinson D, Wu Y, Kalyana Sundaram S, Cao X, Lonigro R, Sung Y, et al. Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet. 2013;45:180-5 pubmed publisher
    ..A gene fusion of the transcriptional repressor NAB2 with the transcriptional activator STAT6 was detected...
  30. Cui X, Zhang L, Luo J, Rajasekaran A, Hazra S, Cacalano N, et al. Unphosphorylated STAT6 contributes to constitutive cyclooxygenase-2 expression in human non-small cell lung cancer. Oncogene. 2007;26:4253-60 pubmed
    ..Our data indicate unphosphorylated signal transducers and activators of transcription 6 (STAT6) may transcriptionally upregulate COX-2 expression and protect against apoptosis in NSCLC cells...
  31. Agaimy A, Haller F, Hartmann A. [Sinonasal tumors : News from the WHO with special reference to mesenchymal entities]. Pathologe. 2018;39:18-26 pubmed publisher
    ..Recognition of CTNNB1 mutations and STAT6/NAB2 gene fusions as defining genetic markers for sinonasal hemangio‑/glomangiopericytoma and solitary ..
  32. Fleming B, Chandrasekaran P, Dillon L, Dalby E, Suresh R, Sarkar A, et al. The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling. J Leukoc Biol. 2015;98:395-407 pubmed publisher
    ..This ability to regulate innate-immune responses occurred equally well in macrophages from STAT6-deficient mice...
  33. Wang C, Qi Y, Liu R, Lan J, Zhou Y, Ju X, et al. Immunohistochemical evaluation of stem cell markers and signal transducer and activator of transcription 6 (STAT6) in solitary fibrous tumors. Int J Clin Exp Pathol. 2015;8:10585-94 pubmed
    ..of stem cell markers [aldehyde dehydrogenase 1 (ALDH1), CD29, CD44, CD133, and nestin] and signal transducer and activator of transcription 6 (STAT6) in 18 cases of SFT...
  34. Zingaretti C, Arigò M, Cardaci A, Moro M, Crosti M, Sinisi A, et al. Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis. Mol Cell Proteomics. 2012;11:1885-97 pubmed publisher
    ..Remarkably, patients' sera inhibited STAT6 phosphorylation induced by IL4 binding to CD124, demonstrating that these autoantibodies are functional and ..
  35. Su X, Esser A, Amend S, Xiang J, Xu Y, Ross M, et al. Antagonizing Integrin ?3 Increases Immunosuppression in Cancer. Cancer Res. 2016;76:3484-95 pubmed publisher
    ..wherein integrin ?3 signaling favored STAT1 activation, an M1-polarizing signal, and suppressed M2-polarizing STAT6 activation...
  36. Kavalar M, Balantic M, Silar M, Kosnik M, Korosec P, Rijavec M. Association of ORMDL3, STAT6 and TBXA2R gene polymorphisms with asthma. Int J Immunogenet. 2012;39:20-5 pubmed publisher
    ..Another asthma candidate gene is signal transducer and activator of transcription 6 (STAT6), a regulator of IgE class switching...
  37. Cao H, Zhang J, Liu H, Wan L, Zhang H, Huang Q, et al. IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells. Oncotarget. 2016;7:61183-61198 pubmed publisher
    ..Importantly, STAT6 signaling inhibitor and STAT6 knockdown significantly reversed IL-13-induced EMT and ZEB1 induction in CRC cells, ..
  38. Hynds R, Gowers K, Nigro E, Butler C, Bonfanti P, Giangreco A, et al. Cross-talk between human airway epithelial cells and 3T3-J2 feeder cells involves partial activation of human MET by murine HGF. PLoS ONE. 2018;13:e0197129 pubmed publisher
    ..lines but stimulates the phosphorylation of GRB2-associated-binding protein 2 (GAB2) and signal transducer and activator of transcription 6 (STAT6)...
  39. Mullings R, Wilson S, Puddicombe S, Lordan J, Bucchieri F, Djukanovic R, et al. Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium. J Allergy Clin Immunol. 2001;108:832-8 pubmed
    ..Because many of the effects of these cytokines are mediated by activation of signal transducer and activator of transcription 6 (STAT-6), we investigated expression and function of this transcription factor in the ..
  40. Schjerven H, Brandtzaeg P, Johansen F. Hepatocyte NF-1 and STAT6 cooperate with additional DNA-binding factors to activate transcription of the human polymeric Ig receptor gene in response to IL-4. J Immunol. 2003;170:6048-56 pubmed
    ..We have previously identified a STAT6 site in intron 1 of the human pIgR gene that is required for the slow and de novo protein synthesis-dependent IL-4-..
  41. Zeis T, Howell O, Reynolds R, Schaeren Wiemers N. Molecular pathology of Multiple Sclerosis lesions reveals a heterogeneous expression pattern of genes involved in oligodendrogliogenesis. Exp Neurol. 2018;305:76-88 pubmed publisher
    ..Among them, we found an increased expression of members of the STAT6 pathway such as STAT6, IL4 and IL4R in active, remyelinated and inactive demyelinated lesions...
  42. Raingeaud J, Pierre J. Interleukin-4 downregulates TNFalpha-induced IL-8 production in keratinocytes. FEBS Lett. 2005;579:3953-9 pubmed
    ..Moreover, overexpression of either the endogenous JAK inhibitor SOCS-1 or a dominant negative form of the STAT6 transcription factor (STAT6DeltaC) interferes with the IL-4 inhibitory effect on IL-8 promoter...
  43. Koukouikila Koussounda F, Ntoumi F, Ndounga M, Tong H, Abena A, Velavan T. Genetic evidence of regulatory gene variants of the STAT6, IL10R and FOXP3 locus as a susceptibility factor in uncomplicated malaria and parasitaemia in Congolese children. Malar J. 2013;12:9 pubmed publisher
    ..The aim of this study was to evaluate possible associations between regulatory gene polymorphisms and the risk of uncomplicated malaria and the control of Plasmodium falciparum parasite density levels...
  44. So E, Oh J, Jang J, Kim J, Lee C. Ras/Erk pathway positively regulates Jak1/STAT6 activity and IL-4 gene expression in Jurkat T cells. Mol Immunol. 2007;44:3416-26 pubmed
    ..cytokine-producing Jurkat T cells, we have found that IL-4 induces activation of Erk and Akt, and the IL-4-induced STAT6 activity is suppressed by inhibitors of Erk and PI3K...
  45. Dubey R, Saini N. STAT6 silencing up-regulates cholesterol synthesis via miR-197/FOXJ2 axis and induces ER stress-mediated apoptosis in lung cancer cells. Biochim Biophys Acta. 2015;1849:32-43 pubmed publisher
    ..Previously, using genome-wide expression profiling studies, we have shown an inverse relationship of STAT6 and cholesterol biosynthesis and also identified FOXJ2 binding sites in the upstream region of 3 key genes (HMGCR, ..
  46. Kim Y, Ninomiya Y, Yamashita S, Kumazoe M, Huang Y, Nakahara K, et al. IL-4 receptor ? in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation. Biochem Biophys Res Commun. 2014;450:824-30 pubmed publisher
    ..However, it is unclear how strictinin inhibits STAT6 activation. Strictinin inhibited STAT6 phosphorylation by suppressing IL-4 receptor ? (IL-4R?) activation...
  47. Hirakawa S, Saito R, Ohara H, Okuyama R, Aiba S. Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes. J Immunol. 2011;186:4762-70 pubmed publisher
    ..Finally, we demonstrated that the increased expression of DUOX1 in IL-4/IL-13-treated NHEK augments STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B...
  48. Jiang Q, Liu Z, Zhou Z, Wang L, Wang L, Yue F, et al. Transcriptional activation and translocation of ancient NOS during immune response. FASEB J. 2016;30:3527-3540 pubmed
    ..diacylglycerol kinase ?, LPS-induced TNF-? factor-like protein, cAMP-dependent transcription factor-2, NF-?B1, and STAT6 were significantly elevated in a transcriptome analysis after 12 h of LPS and TNF-? stimulation...
  49. Zhang W, Zheng X, Du L, Sun J, Shen Z, Shi C, et al. High salt primes a specific activation state of macrophages, M(Na). Cell Res. 2015;25:893-910 pubmed publisher
    ..pathways, while inhibited the anti-inflammatory and proendocytic aspects by Erk1/2/signal transducer and activator of transcription 6 pathway...
  50. Karpathiou G, Stefanou D, Froudarakis M. Pleural neoplastic pathology. Respir Med. 2015;109:931-43 pubmed publisher
    ..Solitary fibrous tumor, the commonest primary pleural mesenchymal tumor is characterized by STAT6 overexpression...
  51. Rekhi B, Shetty O, Tripathi P, Bapat P, Ramadwar M, Bajpai J, et al. Molecular characterization of a series of solitary fibrous tumors, including immunohistochemical expression of STAT6 and NATB2-STAT6 fusion transcripts, using Reverse Transcriptase(RT)-Polymerase chain reaction(PCR) technique: An Indian experience. Pathol Res Pract. 2017;213:1404-1411 pubmed publisher
    ..Recent studies have unraveled STAT6 as a useful diagnostic immunohistochemical (IHC) marker for a SFT and NAB2-STAT6 as its specific gene fusion ..
  52. Wirnsberger G, Hebenstreit D, Posselt G, Horejs Hoeck J, Duschl A. IL-4 induces expression of TARC/CCL17 via two STAT6 binding sites. Eur J Immunol. 2006;36:1882-91 pubmed
    ..Mapping of the transcriptional start site revealed the presence of two putative STAT6 binding motifs in proximity to the start position...
  53. Rahal O, Wolfe A, Mandal P, Larson R, Tin S, Jimenez C, et al. Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer. Int J Radiat Oncol Biol Phys. 2018;100:1034-1043 pubmed publisher
    ..Interleukin (IL)4/IL13-induced activation of STAT6 signaling was measured by Western blotting of phospho-STAT6 (Tyr641), and expression of M2 polarization gene ..
  54. Barik S, Miller M, Cattin Roy A, Ukah T, Chen W, Zaghouani H. IL-4/IL-13 Signaling Inhibits the Potential of Early Thymic Progenitors To Commit to the T Cell Lineage. J Immunol. 2017;199:2767-2776 pubmed publisher
    ..Indeed, HR+ ETPs, but not HR- ETPs, exhibit activated STAT6 transcription factor, which parallels with downregulation of Notch1, a critical factor for T cell development...
  55. Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia A, et al. The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. Am J Respir Crit Care Med. 2015;192:998-1008 pubmed publisher
    ..IL-4(-/-)IL-13(-/-) mice had less pulmonary vascular phospho-signal transducer and activator of transcription 6 (STAT6) and phospho-Smad2/3 activity, potentially caused by decreased TGF-β activation by ..
  56. Szanto A, Balint B, Nagy Z, Barta E, Dezso B, Pap A, et al. STAT6 transcription factor is a facilitator of the nuclear receptor PPAR?-regulated gene expression in macrophages and dendritic cells. Immunity. 2010;33:699-712 pubmed publisher
    ..PPAR? activity through an interaction between PPAR? and signal transducer and activators of transcription 6 (STAT6) on promoters of PPAR? target genes, including FABP4...
  57. Kälin S, Becker M, Ott V, Serr I, Hosp F, Mollah M, et al. A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. Cell Metab. 2017;26:475-492.e7 pubmed publisher
    ..gain-of-function studies, including Treg depletion and transfers in vivo, we demonstrated that a T cell-specific Stat6/Pten axis links cold exposure or ADRB3 stimulation with Foxp3+ Treg induction and adipose tissue ..
  58. Vicetti Miguel R, Quispe Calla N, Dixon D, Foster R, Gambotto A, Pavelko S, et al. IL-4-secreting eosinophils promote endometrial stromal cell proliferation and prevent Chlamydia-induced upper genital tract damage. Proc Natl Acad Sci U S A. 2017;114:E6892-E6901 pubmed publisher
    ..Congruent with the aberrant tissue repair in mice with deficient IL-4 signaling, we found that IL-4R? and STAT6 signaling mediated IL-4-induced endometrial stromal cell (ESC) proliferation ex vivo, and that genital ..
  59. Pastuszak Lewandoska D, Domańska Senderowska D, Kordiak J, Antczak A, Czarnecka K, Migdalska Sek M, et al. Immunoexpression analysis of selected JAK/STAT pathway molecules in non-small cell lung cancer patients. Pol Arch Intern Med. 2017;: pubmed publisher
    ..OBJECTIVES To analyze the immunoexpression levels of three STAT proteins: STAT3, STAT5, and STAT6 in their phosphorylated forms, STAT inhibitors PIAS3 and SOCS3, and additionally COX-2, as potential diagnostic ..
  60. Rao Z, Sun J, Pan X, Chen Z, Sun H, Zhang P, et al. Hyperglycemia Aggravates Hepatic Ischemia and Reperfusion Injury by Inhibiting Liver-Resident Macrophage M2 Polarization via C/EBP Homologous Protein-Mediated Endoplasmic Reticulum Stress. Front Immunol. 2017;8:1299 pubmed publisher
    ..as revealed by decreased Arg1 and Mrc1 gene induction accompanied by a decrease in STAT3 and STAT6 signaling pathway activation...
  61. Zhang W, Koltun W, Tilberg A, Thompson J, Chorney M. Genetic control of interleukin-4-induced activation of the human signal transducer and activator of transcription 6 signaling pathway. Hum Immunol. 2003;64:402-15 pubmed
    The interleukin (IL)-4-induced Stat6 signaling pathway is active in a variety of cell types, including immune cells and cancer cells, and plays an important role in the regulation of gene expression, such as CD23 and major ..
  62. Sahoo A, Lee C, Jash A, Son J, Kim G, Kwon H, et al. Stat6 and c-Jun mediate Th2 cell-specific IL-24 gene expression. J Immunol. 2011;186:4098-109 pubmed publisher
    ..In vivo binding of Stat6 and AP-1 (c-Jun) to the IL-24 promoter locus in Th2 cells synergistically transactivated the IL-24 promoter...
  63. Huang Z, Xin J, Coleman J, Huang H. IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor. J Immunol. 2005;174:1332-7 pubmed
    ..However, the mechanism by which IFN-gamma stabilizes Th1 phenotype is not clear. In this study, we compared STAT6 phosphorylation in wild-type (WT) and IFN-gamma receptor knockout (IFNGR(-/-)) Th1 cells...
  64. Yang W, Jin R, Jiang C, Wang X, Shu J, Li L, et al. E3 ubiquitin ligase Cbl-b suppresses human ORMDL3 expression through STAT6 mediation. FEBS Lett. 2015;589:1975-80 pubmed publisher
    ..Further investigation showed that phosphorylation of signal transducer and activator of transcription 6 (STAT6) was induced by interleukin 4 bound to the ORMDL3 promoter, while Cbl-b reduced the ..
  65. Maier E, Werner D, Duschl A, Bohle B, Horejs Hoeck J. Human Th2 but not Th9 cells release IL-31 in a STAT6/NF-?B-dependent way. J Immunol. 2014;193:645-54 pubmed publisher
    ..We show that STAT6 and NF-?B are central players in mediating IL-31 expression induced by IL-4/IL-33...
  66. Goto K, Chiba Y, Matsusue K, Hattori Y, Maitani Y, Sakai H, et al. The proximal STAT6 and NF-kappaB sites are responsible for IL-13- and TNF-alpha-induced RhoA transcriptions in human bronchial smooth muscle cells. Pharmacol Res. 2010;61:466-72 pubmed publisher
    ..level of promoter activity between the 112 bp upstream and the transcription start site, which contains the STAT6 (78-70 bp upstream) and NF-kappaB (84-74 bp upstream) binding regions...
  67. Weise C, Hilt K, Milovanovic M, Ernst D, Ruhl R, Worm M. Inhibition of IgE production by docosahexaenoic acid is mediated by direct interference with STAT6 and NF?B pathway in human B cells. J Nutr Biochem. 2011;22:269-75 pubmed publisher
    ..a decreased IL-4 receptor expression which was associated with a reduction of IL-4 driven signal transducer and activator of transcription 6 phosphorylation...
  68. Dong L, Zhang X, Fu X, Zhang X, Gao X, Zhu M, et al. PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1. J Biol Chem. 2011;286:3451-9 pubmed publisher
    ..In IL-4/IL-13 signaling several coactivators for STAT6 have been identified, but the molecular mechanisms of STAT6-mediated gene transcription are still not fully ..
  69. Creytens D, Ferdinande L. Diagnostic Utility of STAT6 Immunohistochemistry in the Diagnosis of Fat-forming Solitary Fibrous Tumors. Appl Immunohistochem Mol Morphol. 2016;24:e12-3 pubmed publisher
  70. Chevrier S, Kratina T, Emslie D, Tarlinton D, Corcoran L. IL4 and IL21 cooperate to induce the high Bcl6 protein level required for germinal center formation. Immunol Cell Biol. 2017;95:925-932 pubmed publisher
    ..b>Stat6, downstream of IL4, can induce Bcl6 transcription directly...
  71. Ritz O, Rommel K, Dorsch K, Kelsch E, Melzner J, Buck M, et al. STAT6-mediated BCL6 repression in primary mediastinal B-cell lymphoma (PMBL). Oncotarget. 2013;4:1093-102 pubmed
    ..is characterized by aberrant activation of JAK/STAT-signaling resulting in constitutive presence of phosphorylated STAT6 (pSTAT6)...
  72. Bhanoori M, Deenadayal M, Kennedy S, Shivaji S. The G2964A 3'-untranslated region polymorphism of the signal transducer and activator of transcription 6 gene is associated with endometriosis in South Indian women. Hum Reprod. 2007;22:1026-30 pubmed
    The aim of the study was to test whether the signal transducer and activator of transcription 6 (STAT6) gene influences the risk of developing endometriosis...
  73. Darcan Nicolaisen Y, Meinicke H, Fels G, Hegend O, Haberland A, Kühl A, et al. Small interfering RNA against transcription factor STAT6 inhibits allergic airway inflammation and hyperreactivity in mice. J Immunol. 2009;182:7501-8 pubmed publisher
    In the context of allergic immune responses, activation of STAT6 is pivotal for Th2-mediated IgE production and development of airway inflammation and hyperreactivity...
  74. Binnemars Postma K, Bansal R, Storm G, Prakash J. Targeting the Stat6 pathway in tumor-associated macrophages reduces tumor growth and metastatic niche formation in breast cancer. FASEB J. 2017;: pubmed publisher
    ..In this study, we hypothesized that the inhibition of the signal transducer and activator of transcription 6 (Stat6) pathway, a common downstream signaling pathway of IL-4 and IL-13, may be an ..
  75. Xu S, Liu X, Li B, Zhang Y, Yuan J, Yuan Q, et al. DNA methylation regulates constitutive expression of Stat6 regulatory genes SOCS-1 and SHP-1 in colon cancer cells. J Cancer Res Clin Oncol. 2009;135:1791-8 pubmed publisher
    b>Stat6 signaling is active in cancer cells and IL-4-induced Stat6 activities or Stat6 activational phenotypes vary among cancer cells...
  76. Jiang H, Harris M, Rothman P. IL-4/IL-13 signaling beyond JAK/STAT. J Allergy Clin Immunol. 2000;105:1063-70 pubmed
    ..use Janus kinases (JAKs) to initiate signaling and activate signal transducer and activator of transcription-6 (STAT6), which is a transcription factor required for many of their biologic functions...