STAT5

Summary

Gene Symbol: STAT5
Description: signal transducer and activator of transcription 5A
Alias: MGF, STAT5, signal transducer and activator of transcription 5A
Species: human
Products:     STAT5

Top Publications

  1. Dentelli P, Trombetta A, Togliatto G, Zeoli A, Rosso A, Uberti B, et al. Formation of STAT5/PPARgamma transcriptional complex modulates angiogenic cell bioavailability in diabetes. Arterioscler Thromb Vasc Biol. 2009;29:114-20 pubmed publisher
    ..CACs) expansion is a multistage process requiring sequential activation of transcriptional factors, including STAT5. STAT5, in concert with peroxisome proliferator-activated receptors (PPARs), seems to induce discrete biological ..
  2. Nevalainen M, Xie J, Torhorst J, Bubendorf L, Haas P, Kononen J, et al. Signal transducer and activator of transcription-5 activation and breast cancer prognosis. J Clin Oncol. 2004;22:2053-60 pubmed
    Transcription factor signal transducer and activator of transcription-5 (Stat5) promotes breast epithelial cell differentiation. We retrospectively analyzed whether levels of active Stat5 in breast cancer were linked to clinical outcome...
  3. Nelson E, Walker S, Weisberg E, Bar Natan M, Barrett R, Gashin L, et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood. 2011;117:3421-9 pubmed publisher
    The transcription factor STAT5 is an essential mediator of the pathogenesis of chronic myelogenous leukemia (CML)...
  4. Friedbichler K, Kerenyi M, Kovacic B, Li G, Hoelbl A, Yahiaoui S, et al. Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation. Blood. 2010;116:1548-58 pubmed publisher
    b>Stat5 transcription factors are essential gene regulators promoting proliferation, survival, and differentiation of all hematopoietic cell types...
  5. Tran T, Utama F, Lin J, Yang N, Sjolund A, Ryder A, et al. Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism. Cancer Res. 2010;70:1711-21 pubmed publisher
    ..DNA target sequences similar to those recognized by signal transducer and activator of transcriptions 5 (Stat5)...
  6. Jenks J, Seki S, Kanai T, Huang J, Morgan A, Scalco R, et al. Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells. Clin Immunol. 2013;148:227-36 pubmed publisher
    ..These results indicate that STAT5B and STAT5A act partly as non-redundant transcription factors and that STAT5B is more critical for Treg maintenance and function in humans. ..
  7. Olthof S, Fatrai S, Drayer A, Tyl M, Vellenga E, Schuringa J. Downregulation of signal transducer and activator of transcription 5 (STAT5) in CD34+ cells promotes megakaryocytic development, whereas activation of STAT5 drives erythropoiesis. Stem Cells. 2008;26:1732-42 pubmed publisher
    ..We have identified signal transducer and activator of transcription 5 (STAT5) as a critical denominator that determined lineage commitment between erythroid and megakaryocytic cell fates...
  8. de Totero D, Meazza R, Capaia M, Fabbi M, Azzarone B, Balleari E, et al. The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways. Blood. 2008;111:517-24 pubmed
    ..Following cell exposure to IL-15, phosphorylation of STAT5 was predominantly observed, whereas, following stimulation with IL-21, there was predominant STAT1 and STAT3 ..
  9. Warsch W, Grundschober E, Berger A, Gille L, Cerny Reiterer S, Tigan A, et al. STAT5 triggers BCR-ABL1 mutation by mediating ROS production in chronic myeloid leukaemia. Oncotarget. 2012;3:1669-87 pubmed
    We recently reported that chronic myeloid leukaemia (CML) patients harbour high levels of STAT5 when they progress to advanced phases of disease. Advanced disease is characterized by an increased incidence of BCR-ABL1 mutations...

More Information

Publications73

  1. Buitenhuis M, Baltus B, Lammers J, Coffer P, Koenderman L. Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells. Blood. 2003;101:134-42 pubmed
    ..eosinophil differentiation is induced by interleukin-5 (IL-5), which has also been demonstrated to activate STAT5. We have investigated whether STAT5 plays a critical role during eosinophil differentiation using umbilical cord ..
  2. Lin J, Mietz J, Modi W, John S, Leonard W. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. J Biol Chem. 1996;271:10738-44 pubmed
    We have isolated a second human Stat5 cDNA, Stat5B, and demonstrated that the genes encoding both Stat5A and Stat5B are located at chromosome 17q11.2. Both genes were constitutively transcribed in peripheral blood lymphocytes...
  3. Juffroy O, Bugault F, Lambotte O, Landires I, Viard J, Niel L, et al. Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway. J Virol. 2010;84:96-108 pubmed publisher
    ..The basal level of pSTAT5 was also increased, indicating a constitutive activation of the JAK/STAT5 pathway...
  4. Fang F, Rycyzyn M, Clevenger C. Role of c-Myb during prolactin-induced signal transducer and activator of transcription 5a signaling in breast cancer cells. Endocrinology. 2009;150:1597-606 pubmed publisher
    ..the prolactin receptor (PRLr)-associated Janus kinase 2 (Jak2)/signal transducer and activator of transcription 5 (Stat5) signaling complex...
  5. Xu R, Spencer V, Bissell M. Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors. J Biol Chem. 2007;282:14992-9 pubmed
    ..Co-immunoprecipitation analyses showed that the SWI/SNF complex is associated with STAT5, CCAAT/enhancer-binding protein beta, and glucocorticoid receptor...
  6. Harir N, Pecquet C, Kerenyi M, Sonneck K, Kovacic B, Nyga R, et al. Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias. Blood. 2007;109:1678-86 pubmed
    Persistent activation of Stat5 is frequently found in hematologic neoplasms. Studies conducted with constitutively active Stat5 mutants (Stat51*6 and cS5F) have shown that deregulated Stat5 activity promotes leukemogenesis...
  7. Wierenga A, Schepers H, Moore M, Vellenga E, Schuringa J. STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBPalpha. Blood. 2006;107:4326-33 pubmed
    ..The present study identifies C/EBPalpha as a critical component that is down-regulated by STAT5. Microarray and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis on STAT5A(1*6)-transduced CD34(+)..
  8. Wang Y, Cheng C. ERalpha and STAT5a cross-talk: interaction through C-terminal portions of the proteins decreases STAT5a phosphorylation, nuclear translocation and DNA-binding. FEBS Lett. 2004;572:238-44 pubmed
    ..These data serve to elucidate the mechanisms underlying the ERalpha-STAT5a cross-talk and in demonstrating that the functional consequence of this cross-talk depends on the precise milieus of the intracellular environment. ..
  9. Chin H, Nakamura N, Kamiyama R, Miyasaka N, Ihle J, Miura O. Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3. Blood. 1996;88:4415-25 pubmed
    ..IL-3) stimulate activation of the Jak2 tyrosine kinase and induce tyrosine phosphorylation and activation of Stat5. In the present study, we have shown that Epo or IL-3 stimulation induces binding of Stat5 to the tyrosine-..
  10. Brockman J, Schroeder M, Schuler L. PRL activates the cyclin D1 promoter via the Jak2/Stat pathway. Mol Endocrinol. 2002;16:774-84 pubmed
    ..Furthermore, this increase in promoter activity is predominantly mediated by the Jak2/Stat5 signaling pathway...
  11. Litterst C, Kliem S, Marilley D, Pfitzner E. NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. J Biol Chem. 2003;278:45340-51 pubmed
    Signal transducer and activator of transcription 5 (STAT5) is a transcription factor that activates prolactin (PRL)-dependent gene expression in the mammary gland...
  12. Wierenga A, Vellenga E, Schuringa J. Down-regulation of GATA1 uncouples STAT5-induced erythroid differentiation from stem/progenitor cell proliferation. Blood. 2010;115:4367-76 pubmed publisher
    ..we have shown that overexpression of an activated mutant of signal transducer and activator of transcription-5 (STAT5) induces erythropoiesis, impaired myelopoiesis, and an increase in long-term proliferation of human hematopoietic ..
  13. Gu L, Vogiatzi P, Puhr M, Dagvadorj A, Lutz J, Ryder A, et al. Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo. Endocr Relat Cancer. 2010;17:481-93 pubmed publisher
    There are no effective therapies for disseminated prostate cancer. Constitutive activation of Stat5 in prostate cancer is associated with cancer lesions of high histological grade...
  14. Tang J, Zuo Z, Kong X, Steiner M, Yin Z, Perry J, et al. Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior. Endocrinology. 2010;151:43-55 pubmed publisher
    ..Xenograft studies provided data concordant with the in vitro effects of the two STAT5 isoforms...
  15. Pfitzner E, Jähne R, Wissler M, Stoecklin E, Groner B. p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response. Mol Endocrinol. 1998;12:1582-93 pubmed
    b>Stat5 was discovered as a PRL-induced member of the Stat (signal transducer and activator of transcription) family...
  16. Olayioye M, Beuvink I, Horsch K, Daly J, Hynes N. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J Biol Chem. 1999;274:17209-18 pubmed
    ..In this report we show that ErbB2, ErbB3, and ErbB4 do not potentiate Stat5 phosphorylation by EGF...
  17. Wierenga A, Vellenga E, Schuringa J. Maximal STAT5-induced proliferation and self-renewal at intermediate STAT5 activity levels. Mol Cell Biol. 2008;28:6668-80 pubmed publisher
    ..By extensive gene expression profiling we could identify gene expression patterns of STAT5 target genes that predominantly associated with a self-renewal and long-term expansion phenotype versus those that ..
  18. Mallette F, Gaumont Leclerc M, Huot G, Ferbeyre G. Myc down-regulation as a mechanism to activate the Rb pathway in STAT5A-induced senescence. J Biol Chem. 2007;282:34938-44 pubmed
    ..correlated with its localization to promyelocytic leukemia bodies, which were found to be highly abundant during STAT5-induced senescence...
  19. Kieslinger M, Woldman I, Moriggl R, Hofmann J, Marine J, Ihle J, et al. Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Genes Dev. 2000;14:232-44 pubmed
    b>Stat5 is activated by multiple receptors of hematopoietic cytokines. To study its role during hematopoiesis, we have generated primary chicken myeloblasts expressing different dominant-negative (dn) alleles of Stat5...
  20. Barash I. Stat5 in breast cancer: potential oncogenic activity coincides with positive prognosis for the disease. Carcinogenesis. 2012;33:2320-5 pubmed publisher
    ..This positive characteristic is counteracted by studies in laboratory animals demonstrating that deregulated Stat5 activity may convert proper mammary development into a latent oncogenic process...
  21. Li H, Zhang Y, Glass A, Zellweger T, Gehan E, Bubendorf L, et al. Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence. Clin Cancer Res. 2005;11:5863-8 pubmed
    We have shown previously that the signal transducer and activator of transcription-5 (Stat5) is a critical survival factor in human prostate cancer cells...
  22. Garcon L, Rivat C, James C, Lacout C, Camara Clayette V, Ugo V, et al. Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells. Blood. 2006;108:1551-4 pubmed
    ..In this work, we studied whether the STAT5/Bcl-xL pathway could be responsible for EEC formation...
  23. Schwaller J, Parganas E, Wang D, Cain D, Aster J, Williams I, et al. Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2. Mol Cell. 2000;6:693-704 pubmed
    b>STAT5 is activated in a broad spectrum of human hematologic malignancies. We addressed whether STAT5 activation is necessary for the myelo- and lymphoproliferative disease induced by TEL/JAK2 using a genetic approach...
  24. Oda A, Wakao H, Fujita H. Calpain is a signal transducer and activator of transcription (STAT) 3 and STAT5 protease. Blood. 2002;99:1850-2 pubmed
    ..We found that calpain, a ubiquitously expressed cysteine protease, also trims STAT5 in vivo and in vitro, within the carboxy-terminal domain...
  25. Fung M, Chu Y, Fink J, Wallace A, McGuire K. IL-2- and STAT5-regulated cytokine gene expression in cells expressing the Tax protein of HTLV-1. Oncogene. 2005;24:4624-33 pubmed
    ..These studies show that, of the signaling pathways evaluated, only STAT5 remains dependent...
  26. Lanvin O, Gouilleux F, Mullié C, Mazière C, Fuentes V, Bissac E, et al. Interleukin-7 induces apoptosis of 697 pre-B cells expressing dominant-negative forms of STAT5: evidence for caspase-dependent and -independent mechanisms. Oncogene. 2004;23:3040-7 pubmed
    ..In this work, we aimed to investigate the role of STAT5 in human precursor B cell survival by introducing dominant-negative (DN) forms of STAT5A or STAT5B in the 697 pre-..
  27. Walker S, Nelson E, Zou L, Chaudhury M, Signoretti S, Richardson A, et al. Reciprocal effects of STAT5 and STAT3 in breast cancer. Mol Cancer Res. 2009;7:966-76 pubmed publisher
    ..b>STAT5 and STAT3 mediate opposing effects on several key target genes, with STAT5 exerting a dominant role...
  28. Sultan A, Xie J, LeBaron M, Ealley E, Nevalainen M, Rui H. Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells. Oncogene. 2005;24:746-60 pubmed
    Signal transducer and activator of transcription-5 (Stat5) mediates prolactin (PRL)-induced differentiation and growth of breast epithelial cells...
  29. Peng B, Sutherland K, Sum E, Olayioye M, Wittlin S, Tang T, et al. CPAP is a novel stat5-interacting cofactor that augments stat5-mediated transcriptional activity. Mol Endocrinol. 2002;16:2019-33 pubmed
    b>Stat5, a member of the signal transducer and activators of transcription (Stat) protein family, is a primary mediator of prolactin (PRL) signaling in the mammary gland. There are two distinct Stat5 genes, Stat5a and Stat5b...
  30. Warsch W, Kollmann K, Eckelhart E, Fajmann S, Cerny Reiterer S, Hölbl A, et al. High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia. Blood. 2011;117:3409-20 pubmed publisher
    ..Here we show that the expression level of the transcription factor STAT5 is another parameter that determines the sensitivity of BCR-ABL1(+) cells against tyrosine kinase inhibitors (TKIs)..
  31. Nelson E, Walker S, Li W, Liu X, Frank D. Identification of human STAT5-dependent gene regulatory elements based on interspecies homology. J Biol Chem. 2006;281:26216-24 pubmed
    b>STAT5 is a transcription factor essential for hematopoietic physiology. STAT5 functions to transduce signals from cytokines to the nucleus where it regulates gene expression...
  32. Fatrai S, Wierenga A, Daenen S, Vellenga E, Schuringa J. Identification of HIF2alpha as an important STAT5 target gene in human hematopoietic stem cells. Blood. 2011;117:3320-30 pubmed publisher
    The transcription factor signal transducer and activator of transcription 5 (STAT5) fulfills essential roles in self-renewal in mouse and human hematopoietic stem cells (HSCs), and its persistent activation contributes to leukemic ..
  33. Sobti R, Singh N, Hussain S, Suri V, Bharadwaj M, Das B. Deregulation of STAT-5 isoforms in the development of HPV-mediated cervical carcinogenesis. J Recept Signal Transduct Res. 2010;30:178-88 pubmed publisher
    ..001). We observed for the first time the differential expression pattern of STAT-5 isoforms in cervical cancer and that STAT-5 may play an important role in the progression of HPV-mediated cervical cancer. ..
  34. Schuringa J, Chung K, Morrone G, Moore M. Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation. J Exp Med. 2004;200:623-35 pubmed
    ..Constitutive activation of STAT5 has also been associated with leukemic transformation...
  35. Moriggl R, Sexl V, Kenner L, Duntsch C, Stangl K, Gingras S, et al. Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell. 2005;7:87-99 pubmed
    Activation of Stat5 is frequently found in leukemias. To study the mechanism and role of Stat5 activation, we introduced a constitutively activated Stat5a mutant, cS5F, into murine bone marrow (BM) cells...
  36. Zeoli A, Dentelli P, Rosso A, Togliatto G, Trombetta A, Damiano L, et al. Interleukin-3 promotes expansion of hemopoietic-derived CD45+ angiogenic cells and their arterial commitment via STAT5 activation. Blood. 2008;112:350-61 pubmed publisher
    ..Depletion of signal transducer and activator of transcription 5 (STAT5) provides evidence that IL-3-mediated cell expansion and arterial morphogenesis rely on STAT5 activation...
  37. Socolovsky M, Fallon A, Wang S, Brugnara C, Lodish H. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell. 1999;98:181-91 pubmed
    ..b>Stat5 is rapidly activated following EpoR stimulation, but its function in erythropoiesis has been unclear since adult ..
  38. Soldaini E, John S, Moro S, Bollenbacher J, Schindler U, Leonard W. DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites. Mol Cell Biol. 2000;20:389-401 pubmed
    ..These data provide insights into tetramer formation by Stat5a and indicate that the repertoire of potential binding sites for this transcription factor is broader than expected. ..
  39. Chatain N, Ziegler P, Fahrenkamp D, Jost E, Moriggl R, Schmitz Van de Leur H, et al. Src family kinases mediate cytoplasmic retention of activated STAT5 in BCR-ABL-positive cells. Oncogene. 2013;32:3587-97 pubmed publisher
    ..Among many other substrates BCR-ABL phosphorylates STAT5 and Src family kinases (SFK)...
  40. Johnson K, Peck A, Liu C, Tran T, Utama F, Sjolund A, et al. PTP1B suppresses prolactin activation of Stat5 in breast cancer cells. Am J Pathol. 2010;177:2971-83 pubmed publisher
    Basal levels of nuclear localized, tyrosine phosphorylated Stat5 are present in healthy human breast epithelia...
  41. Walker S, Nelson E, Yeh J, Pinello L, Yuan G, Frank D. STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6. Mol Cell Biol. 2013;33:2879-90 pubmed publisher
    Inappropriate activation of the transcription factors STAT3 and STAT5 has been shown to drive cancer pathogenesis through dysregulation of genes involved in cell survival, growth, and differentiation...
  42. Cotarla I, Ren S, Zhang Y, Gehan E, Singh B, Furth P. Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers. Int J Cancer. 2004;108:665-71 pubmed
    ..As its role in human breast cancer progression and response to therapy is defined, Stat5a could become a new molecular target for breast cancer therapy. ..
  43. Xu B, Wang X, Darus C, Kopchick J. Growth hormone promotes the association of transcription factor STAT5 with the growth hormone receptor. J Biol Chem. 1996;271:19768-73 pubmed
    ..Also, GH has recently been shown to activate the transcription factor STAT5 by tyrosine phosphorylation...
  44. Li H, Zhao W, Shi Y, Li Y, Zhang L, Zhang H, et al. Retinoic acid amide inhibits JAK/STAT pathway in lung cancer which leads to apoptosis. Tumour Biol. 2015;36:8671-8 pubmed publisher
    ..It caused inhibition of JAK2, STAT3, and STAT5, increased the level of p21WAF1, and decreased cyclin A, cyclin B1, and Bcl-XL expression...
  45. van de Laar L, van den Bosch A, Wierenga A, Janssen H, Coffer P, Woltman A. Tight control of STAT5 activity determines human CD34-derived interstitial dendritic cell and langerhans cell development. J Immunol. 2011;186:7016-24 pubmed publisher
    ..b>STAT5 regulates various hematopoietic lineages and is activated by GM-CSF, a critical cytokine in DC development...
  46. Liu Z, Apontes P, Fomenko E, Chi N, Schuster V, Kurland I, et al. Mangiferin Accelerates Glycolysis and Enhances Mitochondrial Bioenergetics. Int J Mol Sci. 2018;19: pubmed publisher
    ..Previously, we identified a natural compound, mangiferin (MGF) that improved glucose utilization in high fat diet (HFD)-induced insulin resistant mice...
  47. Singh S, Kumar D, Rathore A. Determination of Critical Quality Attributes for a Biotherapeutic in the QbD Paradigm: GCSF as a Case Study. AAPS J. 2017;19:1826-1841 pubmed publisher
    ..PD data along with differential expression of JAK-2 and STAT5a genes show that all the tested variants triggered the required signal transduction pathways for neutrophil proliferation and activation. ..
  48. Martínez Moreno C, Ávila Mendoza J, Wu Y, Arellanes Licea E, Louie M, Luna M, et al. Neuroprotection by GH against excitotoxic-induced cell death in retinal ganglion cells. Gen Comp Endocrinol. 2016;234:68-80 pubmed publisher
    ..This neuroprotective action was likely mediated by increased STAT5 phosphorylation and increased bcl-2 production, as induced by exogenous rcGH treatment and the media from GH-..
  49. Mulero Navarro S, Sevilla A, Román A, Lee D, D Souza S, Pardo S, et al. Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11-Associated Juvenile Myelomonocytic Leukemia. Cell Rep. 2015;13:504-515 pubmed publisher
    ..hiPSC-derived NS/JMML myeloid cells exhibited increased signaling through STAT5 and upregulation of miR-223 and miR-15a...
  50. Hong S, Dutta A, Laimins L. The acetyltransferase Tip60 is a critical regulator of the differentiation-dependent amplification of human papillomaviruses. J Virol. 2015;89:4668-75 pubmed publisher
    ..Furthermore, the innate immune regulator STAT-5 and the kinase GSK3β mediate the activation of Tip60 in HPV-positive cells. This study identifies critical regulators of the HPV life cycle. ..
  51. James E, DeVoti J, Rosenthal D, Hatam L, Steinberg B, Abramson A, et al. Papillomavirus-specific CD4+ T cells exhibit reduced STAT-5 signaling and altered cytokine profiles in patients with recurrent respiratory papillomatosis. J Immunol. 2011;186:6633-40 pubmed publisher
    ..Therapeutic vaccination or interventions aimed at restoring Th1-like cytokine responses to HPV proteins and reversing anergy could improve clinical outcomes for RRP patients. ..
  52. Della Chiara G, Crotti A, Liboi E, Giacca M, Poli G, Lusic M. Negative regulation of HIV-1 transcription by a heterodimeric NF-?B1/p50 and C-terminally truncated STAT5 complex. J Mol Biol. 2011;410:933-43 pubmed publisher
    ..of HIV-1(+) individuals, which frequently show a dominant expression of a C-terminally truncated isoform of STAT5 (STAT5?)...
  53. Rani A, Murphy J. STAT5 in Cancer and Immunity. J Interferon Cytokine Res. 2016;36:226-37 pubmed publisher
    ..b>STAT5 proteins are activated by a wide variety of hematopoietic and nonhematopoietic cytokines and growth factors, all ..
  54. Matsuguchi T, Zhao Y, Lilly M, Kraft A. The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation. J Biol Chem. 1997;272:17450-9 pubmed
    ..While the activation of JAK2, Shc, Erk, and STAT5 proteins correlated with hGM-CSF-mediated cell growth, cellular differentiation occurred in the absence of ..
  55. Silva C, Lu H, Day R. Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone. Mol Endocrinol. 1996;10:508-18 pubmed
    ..We demonstrate here that GH activates the tyrosine phosphorylation of STAT5 in the human IM-9 lymphocyte cell line...
  56. Ting C, Lin C, Wen S, Hsieh Li H, Li H. Stat5 constitutive activation rescues defects in spinal muscular atrophy. Hum Mol Genet. 2007;16:499-514 pubmed
    ..compounds (sodium vanadate, trichostatin A and aclarubicin) that effectively enhance SMN2 expression by inducing Stat5 activation in SMA-like mouse embryonic fibroblasts and human SMN2-transfected NSC34 cells...
  57. Fan Q, Cheng C, Gustafson W, Charron E, Zipper P, Wong R, et al. EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell. 2013;24:438-49 pubmed publisher
    ..Subsequent phosphorylation of STAT3 requires nuclear entry of EGFRvIII and formation of an EGFRvIII-STAT3 nuclear complex. Our findings clarify specific oncogenic signaling relationships between EGFR and EGFRvIII in glioblastoma. ..
  58. Oda A, Wakao H, Fujihara M, Ozaki K, Komatsu N, Tanaka S, et al. Thrombopoietin and interleukin-2 induce association of CRK with STAT5. Biochem Biophys Res Commun. 2000;278:299-305 pubmed
    ..coprecipitation and far Western blotting analysis, we demonstrate that Crk (I/II) binds to tyrosine phosphorylated STAT5 in cells stimulated by cytokines such as thrombopoietin (TPO) and interleukin-2 (IL-2)...
  59. Kämpfer S, Odermatt A, Dahinden C, Fux M. Late IL-3-induced phenotypic and functional alterations in human basophils require continuous IL-3 receptor signaling. J Leukoc Biol. 2017;101:227-238 pubmed publisher
    ..the common ?-chain, which enables extraordinarily sustained signaling events, predominantly the activation of Stat5. Of interest, acute IL-3 signaling is not sufficient to induce persistent phenotypical and functional changes in ..
  60. Berg A, Berg T. A small-molecule screen identifies the antitrypanosomal agent suramin and analogues NF023 and NF449 as inhibitors of STAT5a/b. Bioorg Med Chem Lett. 2017;27:3349-3352 pubmed publisher
    ..Our data extend the known in vitro targets of suramin and analogues to include members of the STAT protein family. ..
  61. Drube S, Grimlowski R, Deppermann C, Fröbel J, Kraft F, Andreas N, et al. The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis. J Immunol. 2017;199:2948-2957 pubmed publisher
    ..We found that in mast cells, Nbeal2 regulates the activation of the Shp1-STAT5 signaling axis and the composition of the c-Kit/STAT signalosome...
  62. Knittle A, Helkkula M, Johnson M, Sundvall M, Elenius K. SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase. J Biol Chem. 2017;292:19890-19904 pubmed publisher
    ..compromised neither ErbB4-induced phosphorylation of the canonical signaling pathway effectors Erk1/2, Akt, or STAT5 nor ErbB4 stability. In contrast, SUMOylation was required for nuclear accumulation of the ErbB4 ICD...
  63. Bi E, Ma X, Lu Y, Yang M, Wang Q, Xue G, et al. Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of TH9 cells programmed by IL-7. Sci Signal. 2017;10: pubmed publisher
    ..IL-7 markedly increased the abundance of the histone acetyltransferase p300 by activating the STAT5 and PI3K-AKT-mTOR signaling pathways and promoting the acetylation of histones at the Il9 promoter...
  64. Bao Y, Li J, Zhu Y. Mammary Analog Secretory Carcinoma With ETV6 Rearrangement Arising in the Conjunctiva and Eyelid. Am J Dermatopathol. 2018;40:531-535 pubmed publisher
    ..This type of secretory carcinoma probably originates from sweat glands or accessory lacrimal glands, Wolfring and Krause. This unique case expands the clinicopathologic landscape of MASCs for better characterization of this rare entity. ..