STAT1

Summary

Gene Symbol: STAT1
Description: signal transducer and activator of transcription 1
Alias: CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1-alpha/beta, signal transducer and activator of transcription 1, 91kD, signal transducer and activator of transcription 1, 91kDa, transcription factor ISGF-3 components p91/p84
Species: human
Products:     STAT1

Top Publications

  1. van de Veerdonk F, Plantinga T, Hoischen A, Smeekens S, Joosten L, Gilissen C, et al. STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. N Engl J Med. 2011;365:54-61 pubmed publisher
    ..in the DNA sequence encoding the coiled-coil (CC) domain of signal transducer and activator of transcription 1 (STAT1) in the patients. These mutations lead to defective responses in type 1 and type 17 helper T cells (Th1 and Th17)...
  2. Trusca V, Fuior E, Florea I, Kardassis D, Simionescu M, Gafencu A. Macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1 is achieved via long range genomic interactions. J Biol Chem. 2011;286:13891-904 pubmed publisher
    ..12-myristate 13-acetate-induced differentiation of macrophages is accompanied by a robust induction of apoE and STAT1 expression. In macrophages (but not in hepatocytes), STAT1 up-regulated apoE gene expression via ME.2...
  3. Sikorski K, Chmielewski S, Przybyl L, Heemann U, Wesoly J, Baumann M, et al. STAT1-mediated signal integration between IFN? and LPS leads to increased EC and SMC activation and monocyte adhesion. Am J Physiol Cell Physiol. 2011;300:C1337-44 pubmed publisher
    ..Signal transducer and activated transcription 1 (STAT1) has been identified as a point of convergence for the cross talk between the pro-inflammatory cytokine interferon ..
  4. Dominici S, Brandi G, Schiavano G, Magnani M. Selective killing of Mycobacterium avium-infected macrophages by inhibition of phosphorylated signal transducer and activator of transcription type 1. J Infect Dis. 2008;198:95-100 pubmed publisher
    ..avium. This work invites research on new combination therapeutic approaches that consist of fludarabine, to kill the macrophage reservoir, and antibacterial agents, to eliminate mycobacteria released from the dead cells. ..
  5. Andersen P, Pedersen M, Woetmann A, Villingshøj M, Stockhausen M, Odum N, et al. EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells. Int J Cancer. 2008;122:342-9 pubmed
    ..Ligand-activated EGFR induce expression of IRF-1 via phosphorylation of STAT1 and STAT3...
  6. Uzel G, Sampaio E, Lawrence M, Hsu A, Hackett M, Dorsey M, et al. Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome. J Allergy Clin Immunol. 2013;131:1611-23 pubmed publisher
    ..We sought to investigate the role of STAT1 gain-of-function mutations in phenotypes other than CMC...
  7. Tang X, Gao J, Guan Y, McLane K, Yuan Z, Ramratnam B, et al. Acetylation-dependent signal transduction for type I interferon receptor. Cell. 2007;131:93-105 pubmed
    ..motif by means of its IRF homology2 (IH2) domain, leading to formation of the ISGF3 complex that includes IRF9, STAT1, and STAT2. All three components are acetylated by CBP...
  8. Hix L, Karavitis J, Khan M, Shi Y, Khazaie K, Zhang M. Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells. J Biol Chem. 2013;288:11676-88 pubmed publisher
    Previous studies had implicated the IFN-? transcription factor signal transducer and activator of transcription 1 (STAT1) as a tumor suppressor...
  9. Liu L, Okada S, Kong X, Kreins A, Cypowyj S, Abhyankar A, et al. Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. J Exp Med. 2011;208:1635-48 pubmed publisher
    ..Here, using whole-exome sequencing, we identified heterozygous germline mutations in STAT1 in 47 patients from 20 kindreds with AD CMCD...

More Information

Publications67

  1. Kong X, Ciancanelli M, Al Hajjar S, Alsina L, Zumwalt T, Bustamante J, et al. A novel form of human STAT1 deficiency impairing early but not late responses to interferons. Blood. 2010;116:5895-906 pubmed publisher
    Autosomal recessive STAT1 deficiency is associated with impaired cellular responses to interferons and susceptibility to intracellular bacterial and viral infections...
  2. Duarte C, Willey C, Zhi D, Cui X, Harris J, Vaughan L, et al. Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner. PLoS ONE. 2012;7:e29653 pubmed publisher
    Previous reports have implicated an induction of genes in IFN/STAT1 (Interferon/STAT1) signaling in radiation resistant and prosurvival tumor phenotypes in a number of cancer cell lines, and we have hypothesized that upregulation of ..
  3. Perwitasari O, Cho H, Diamond M, Gale M. Inhibitor of ?B kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection. J Biol Chem. 2011;286:44412-23 pubmed publisher
    ..Here we show that inhibitor of ?B kinase ? (IKK?) phosphorylation of STAT1 at serine 708 (Ser-708) drives IFIT2 expression to mediate anti-WNV effector function of IFN...
  4. Efimova E, Liang H, Pitroda S, Labay E, Darga T, Levina V, et al. Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling. Int J Radiat Biol. 2009;85:421-31 pubmed publisher
    To determine the mechanisms of Signal Transducer and Activator of Transcription 1 (Stat1)-associated radioresistance developed by nu61 tumour selected in vivo by fractionated irradiation of the parental radiosensitive tumour SCC61...
  5. Hong S, Mehta K, Laimins L. Suppression of STAT-1 expression by human papillomaviruses is necessary for differentiation-dependent genome amplification and plasmid maintenance. J Virol. 2011;85:9486-94 pubmed publisher
    ..Overall, our findings demonstrate that suppression of STAT-1 expression by HPV proteins is necessary for genome amplification and maintenance of episomes, suggesting an important role for this activity in viral pathogenesis...
  6. Dimberg L, Dimberg A, Ivarsson K, Fryknäs M, Rickardson L, Tobin G, et al. Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma. BMC Cancer. 2012;12:318 pubmed publisher
    ..The role of Stat1 in MM has not been elucidated, but Stat1 has in several studies been ascribed a pro-apoptotic role...
  7. Koch V, Staab J, Ruppert V, Meyer T. Two glutamic acid residues in the DNA-binding domain are engaged in the release of STAT1 dimers from DNA. BMC Cell Biol. 2012;13:22 pubmed publisher
    In interferon-?-stimulated cells, the dimeric transcription factor STAT1 (signal transducer and activator of transcription 1) recognizes semi-palindromic motifs in the promoter regions of cytokine-driven target genes termed GAS (gamma-..
  8. Simmons J, White L, Morrison T, Montgomery S, Whitmore A, Johnston R, et al. Venezuelan equine encephalitis virus disrupts STAT1 signaling by distinct mechanisms independent of host shutoff. J Virol. 2009;83:10571-81 pubmed publisher
    ..viral infection rapidly disrupts tyrosine phosphorylation and nuclear translocation of the transcription factor STAT1 in response to both IFN-beta and IFN-gamma...
  9. Sanda T, Tyner J, Gutierrez A, Ngo V, Glover J, Chang B, et al. TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer Discov. 2013;3:564-77 pubmed publisher
    ..on a member of the Janus-activated kinase (JAK) tyrosine kinase family, TYK2, and its downstream effector STAT1, in T-cell acute lymphoblastic leukemia (T-ALL)...
  10. Novakova Z, Hubackova S, Kosar M, Janderova Rossmeislova L, Dobrovolna J, Vasicova P, et al. Cytokine expression and signaling in drug-induced cellular senescence. Oncogene. 2010;29:273-84 pubmed publisher
    ..transcription (JAK/STAT) signaling and expression of interferon-stimulated genes (ISGs), such as MX1, OAS, ISG15, STAT1, PML, IRF1 and IRF7, in several human cancer cell lines...
  11. Camicia R, Bachmann S, Winkler H, Beer M, Tinguely M, Haralambieva E, et al. BAL1/ARTD9 represses the anti-proliferative and pro-apoptotic IFN?-STAT1-IRF1-p53 axis in diffuse large B-cell lymphoma. J Cell Sci. 2013;126:1969-80 pubmed publisher
    ..Remarkably, BAL1 stimulates the phosphorylation of both STAT1 isoforms, STAT1? and STAT1?, on Y701 and thereby promotes the nuclear accumulation of the antagonistically acting ..
  12. Magkou C, Giannopoulou I, Theohari I, Fytou A, Rafailidis P, Nomikos A, et al. Prognostic significance of phosphorylated STAT-1 expression in premenopausal and postmenopausal patients with invasive breast cancer. Histopathology. 2012;60:1125-32 pubmed publisher
    ..Our results suggest that pSTAT-1 is related to tumour progression in premenopausal patients through the advanced stage and worse survival. ..
  13. Robertson A, Bilenky M, Tam A, Zhao Y, Zeng T, Thiessen N, et al. Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding. Genome Res. 2008;18:1906-17 pubmed publisher
    ..ChIP-seq profiles for these histone modifications and for two functionally different transcription factors: STAT1 in the immortalized HeLa S3 cell line, with and without interferon-gamma (IFNG) stimulation; and FOXA2 in mouse ..
  14. Tsumura M, Okada S, Sakai H, Yasunaga S, Ohtsubo M, Murata T, et al. Dominant-negative STAT1 SH2 domain mutations in unrelated patients with Mendelian susceptibility to mycobacterial disease. Hum Mutat. 2012;33:1377-87 pubmed publisher
    Patients carrying two loss-of-function (or hypomorphic) alleles of STAT1 are vulnerable to intracellular bacterial and viral diseases...
  15. Canaff L, Zhou X, Hendy G. The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3. J Biol Chem. 2008;283:13586-600 pubmed publisher
    ..Studies with P1 deleted and mutated promoter-reporter and Stat1 and/or Stat3 dominant-negative constructs showed that a Stat1/3 element downstream of the P1 start site accounted ..
  16. Dinwiddie D, Harrod K. Human metapneumovirus inhibits IFN-alpha signaling through inhibition of STAT1 phosphorylation. Am J Respir Cell Mol Biol. 2008;38:661-70 pubmed publisher
    ..cascade showed that hMPV infection prevented IFN-alpha-induced phosphorylation and nuclear translocation of STAT1. The inhibitory effects of hMPV on STAT1 phosphorylation and translocation were abolished by ultraviolet ..
  17. Raven J, Williams V, Wang S, Tremblay M, Muller W, Durbin J, et al. Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation. Cell Cycle. 2011;10:794-804 pubmed
    The anti-tumor function of Stat1 as a regulator of innate immunity and tumor immune surveillance has been long studied and is well understood; however, less clear is its tumor-site specific role...
  18. Zhao L, Huang Y, Tian C, Taylor L, Curthoys N, Wang Y, et al. Interferon-? regulates glutaminase 1 promoter through STAT1 phosphorylation: relevance to HIV-1 associated neurocognitive disorders. PLoS ONE. 2012;7:e32995 pubmed publisher
    ..Furthermore, IFN-? treatment increased signal transducer and activator of transcription 1 (STAT1) phosphorylation and glutaminase mRNA and protein levels...
  19. Dimco G, Knight R, Latchman D, Stephanou A. STAT1 interacts directly with cyclin D1/Cdk4 and mediates cell cycle arrest. Cell Cycle. 2010;9:4638-49 pubmed
    In response to IFN-?, the latent cytoplasmic STAT1 protein is tyrosine phosphorylated and translocates to the nucleus where it transactivates STAT1-responsive genes...
  20. Ginter T, Bier C, Knauer S, Sughra K, Hildebrand D, Münz T, et al. Histone deacetylase inhibitors block IFN?-induced STAT1 phosphorylation. Cell Signal. 2012;24:1453-60 pubmed publisher
    Signal transducer and activator of transcription 1 (STAT1) is important for innate and adaptive immunity. Histone deacetylase inhibitors (HDACi) antagonize unbalanced immune functions causing chronic inflammation and cancer...
  21. Sampaio E, Bax H, Hsu A, Kristosturyan E, Pechacek J, Chandrasekaran P, et al. A novel STAT1 mutation associated with disseminated mycobacterial disease. J Clin Immunol. 2012;32:681-689 pubmed publisher
    b>STAT1 is a key component of Interferon (IFN)-γ and IFN-α signaling and mediates protection against mycobacteria, fungal, viral infections, and cancer...
  22. Villarino A, Gallo E, Abbas A. STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms. J Immunol. 2010;185:6461-71 pubmed publisher
    ..investigated the molecular mechanisms for cytokine-mediated inhibition of Th17 responses, focusing on the role of STAT1 and T-bet in this process...
  23. Renga B, Francisci D, D Amore C, Schiaroli E, Mencarelli A, Cipriani S, et al. The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes. PLoS ONE. 2012;7:e35924 pubmed publisher
    ..The present work identifies p17 as a novel target in HIV therapy and grounds the development of anti-p17 small molecules or vaccines. ..
  24. Zimmerman M, Rahman N, Yang D, Lahat G, Lazar A, Pollock R, et al. Unphosphorylated STAT1 promotes sarcoma development through repressing expression of Fas and bad and conferring apoptotic resistance. Cancer Res. 2012;72:4724-32 pubmed publisher
    b>STAT1 exists in phosphorylated (pSTAT1) and unphosphorylated (uSTAT1) forms each regulated by IFN-?...
  25. Zhang Y, Molavi O, Su M, Lai R. The clinical and biological significance of STAT1 in esophageal squamous cell carcinoma. BMC Cancer. 2014;14:791 pubmed publisher
    Loss of STAT1 (Signal Transducer and Activator of Transcription-1) has been implicated in the pathobiology of a number of cancer types...
  26. Christova R, Jones T, Wu P, Bolzer A, Costa Pereira A, Watling D, et al. P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFNgamma. J Cell Sci. 2007;120:3262-70 pubmed
    ..A single point mutation of STAT1 that prevents phosphorylation is sufficient to abolish chromatin remodelling, thus establishing a direct link ..
  27. Mo W, Zhang L, Yang G, Zhai J, Hu Z, Chen Y, et al. Nuclear beta-arrestin1 functions as a scaffold for the dephosphorylation of STAT1 and moderates the antiviral activity of IFN-gamma. Mol Cell. 2008;31:695-707 pubmed publisher
    Signal transducers and activators of transcription 1 (STAT1) is activated by tyrosine phosphorylation upon interferon-gamma (IFN-gamma) stimulation...
  28. Welzel T, Morgan T, Bonkovsky H, Naishadham D, Pfeiffer R, Wright E, et al. Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial. Hepatology. 2009;49:1847-58 pubmed publisher
    ..006). Genetic polymorphisms in the interferon-alpha pathway may affect responses to antiviral therapy of chronic hepatitis C. ..
  29. Cheon H, Stark G. Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes. Proc Natl Acad Sci U S A. 2009;106:9373-8 pubmed publisher
    In normal human cells treated with interferons (IFNs), the concentration of tyrosine-phosphorylated STAT1 (YP-STAT1), which drives the expression of a large number of genes, increases quickly but then decreases over a period of several ..
  30. Chapgier A, Kong X, Boisson Dupuis S, Jouanguy E, Averbuch D, Feinberg J, et al. A partial form of recessive STAT1 deficiency in humans. J Clin Invest. 2009;119:1502-14 pubmed publisher
    Complete STAT1 deficiency is an autosomal recessive primary immunodeficiency caused by null mutations that abolish STAT1-dependent cellular responses to both IFN-alpha/beta and IFN-gamma...
  31. Hui Z, Tretiakova M, Zhang Z, Li Y, Wang X, Zhu J, et al. Radiosensitization by inhibiting STAT1 in renal cell carcinoma. Int J Radiat Oncol Biol Phys. 2009;73:288-95 pubmed publisher
    ..This study investigated the role of signal transducer and activator of transcription 1 (STAT1), a transcription factor downstream of the interferon-signaling pathway, in radioresistant RCC...
  32. Kramer O, Knauer S, Greiner G, Jandt E, Reichardt S, Gührs K, et al. A phosphorylation-acetylation switch regulates STAT1 signaling. Genes Dev. 2009;23:223-35 pubmed publisher
    ..Histone deacetylases (HDACs) and the histone acetyltransferase (HAT) CBP dynamically regulate STAT1 acetylation...
  33. Lei S, Wu S, Li L, Deng F, Xiao S, Jiang C, et al. An in vivo genome wide gene expression study of circulating monocytes suggested GBP1, STAT1 and CXCL10 as novel risk genes for the differentiation of peak bone mass. Bone. 2009;44:1010-4 pubmed publisher
    ..01) corresponding to 49 unique genes. After false discovery rate adjustment, three genes [STAT1, signal transducer and activator of transcription 1; GBP1, guanylate binding protein 1; CXCL10, Chemokine (C-X-C ..
  34. Shim S, Sung M, Park S, Heo D. Absence of STAT1 disturbs the anticancer effect induced by STAT3 inhibition in head and neck carcinoma cell lines. Int J Mol Med. 2009;23:805-10 pubmed
    The family of signal transducers and activators of transcription (STAT) are transcription factors. Among them, STAT1 is associated with an apoptosis pathway, while STAT3 is associated with tumorigenicity in various cancer cells...
  35. Smeekens S, Plantinga T, van de Veerdonk F, Heinhuis B, Hoischen A, Joosten L, et al. STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis. PLoS ONE. 2011;6:e29248 pubmed publisher
    ..reported the genetic cause of autosomal dominant chronic mucocutaneous candidiasis (AD-CMC) as a mutation in the STAT1 gene...
  36. Greenwood C, Metodieva G, Al Janabi K, Lausen B, Alldridge L, Leng L, et al. Stat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer. J Proteomics. 2012;75:3031-40 pubmed publisher
    ..The first is characterized by high expression of Stat1, Mx1, and CD74...
  37. Sikorski K, Czerwoniec A, Bujnicki J, Wesoly J, Bluyssen H. STAT1 as a novel therapeutical target in pro-atherogenic signal integration of IFN?, TLR4 and IL-6 in vascular disease. Cytokine Growth Factor Rev. 2011;22:211-9 pubmed publisher
    ..More recent studies have revealed that STAT1 is involved in the signaling events mediated by TLR4, leading to increased expression of several pro-inflammatory ..
  38. Chaudhuri A, Yang B, Gendelman H, Persidsky Y, Kanmogne G. STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier. Blood. 2008;111:2062-72 pubmed
    ..We now demonstrate that HIV-1 activates STAT1, induces IL-6 expression, and diminishes expression of claudin-5, ZO-1, and ZO-2 in HBMECs...
  39. Vanhatupa S, Ungureanu D, Paakkunainen M, Silvennoinen O. MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1. Biochem J. 2008;409:179-85 pubmed
    b>STAT1 (signal transducer and activator of transcription 1) is a critical mediator of IFN-gamma (interferon-gamma)-induced gene responses, and its function is regulated through phosphorylation of Tyr701 and Ser727...
  40. Staab J, Herrmann Lingen C, Meyer T. Clinically relevant dimer interface mutants of STAT1 transcription factor exhibit differential gene expression. PLoS ONE. 2013;8:e69903 pubmed publisher
    ..antiparallel dimer configuration of the transcription factor signal transducer and activator of transcription 1 (STAT1) is required for interferon (IFN)-mediated signal transduction...
  41. Harada D, Yamanaka Y, Ueda K, Nishimura R, Morishima T, Seino Y, et al. Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1. Bone. 2007;41:273-81 pubmed
    ..In FGFR3 signaling, the transcription factor, signal transducer and activator of transcription 1 (STAT1) inhibit proliferation and induce apoptosis of chondrocytes...
  42. Huang Y, Walstrom A, Zhang L, Zhao Y, Cui M, Ye L, et al. Type I interferons and interferon regulatory factors regulate TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected macrophages. PLoS ONE. 2009;4:e5397 pubmed publisher
    ..regulatory factor (IRF)-1, IRF-7 gene expression and signal transducers and activators of transcription 1 (STAT1) activation...
  43. Kalliolias G, Ivashkiv L. IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38. J Immunol. 2008;180:6325-33 pubmed
    ..IL-27 activated a STAT1-dominant pattern of signaling in human monocytes with the consequent activation of STAT1-dependent inflammatory ..
  44. Reid S, Valmas C, Martinez O, Sanchez F, Basler C. Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1. J Virol. 2007;81:13469-77 pubmed
    ..alpha/beta interferon (IFN-alpha/beta)- and IFN-gamma-induced nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1) and to inhibit IFN-alpha/beta- and IFN-gamma-induced gene expression...
  45. Wenta N, Strauss H, Meyer S, Vinkemeier U. Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations. Proc Natl Acad Sci U S A. 2008;105:9238-43 pubmed publisher
    ..we use analytical ultracentrifugation and electrophoretic mobility shift assay (EMSA) to study the association of STAT1 in solution before and after tyrosine phosphorylation...
  46. Takezaki S, Yamada M, Kato M, Park M, Maruyama K, Yamazaki Y, et al. Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. J Immunol. 2012;189:1521-6 pubmed publisher
    ..Gain-of-function mutations in STAT1 were very recently shown to be responsible for autosomal-dominant or sporadic cases of CMC...
  47. Sampaio E, Hsu A, Pechacek J, Bax H, Dias D, Paulson M, et al. Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis. J Allergy Clin Immunol. 2013;131:1624-34 pubmed publisher
    ..Dominant gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1) have been associated with chronic mucocutaneous candidiasis...
  48. Yuan C, Qi J, Zhao X, Gao C. Smurf1 protein negatively regulates interferon-? signaling through promoting STAT1 protein ubiquitination and degradation. J Biol Chem. 2012;287:17006-15 pubmed publisher
    ..Here we identified Smurf1 as a negative regulator for IFN-? signaling by targeting STAT1 for ubiquitination and proteasomal degradation...
  49. Renga B, Migliorati M, Mencarelli A, Fiorucci S. Reciprocal regulation of the bile acid-activated receptor FXR and the interferon-gamma-STAT-1 pathway in macrophages. Biochim Biophys Acta. 2009;1792:564-73 pubmed publisher
    ..b>STAT1 silencing and over-expression experiments demonstrated that FXR repression is mediated by INFgamma dependent ..
  50. Kristensen I, Veirum J, Møller B, Christiansen M. Novel STAT1 alleles in a patient with impaired resistance to mycobacteria. J Clin Immunol. 2011;31:265-71 pubmed publisher
    ..Some defects in STAT1 mainly affect IFN-? signaling, thus resulting in mendelian susceptibility to mycobacterial disease (MSMD)...
  51. Wang S, Koromilas A. Stat1 is an inhibitor of Ras-MAPK signaling and Rho small GTPase expression with implications in the transcriptional signature of Ras transformed cells. Cell Cycle. 2009;8:2070-9 pubmed
    The signal transducer and activator of transcription Stat1 plays an indispensable role in the regulation of innate immunity and tumor immuno-surveillance...
  52. Antunes F, Marg A, Vinkemeier U. STAT1 signaling is not regulated by a phosphorylation-acetylation switch. Mol Cell Biol. 2011;31:3029-37 pubmed publisher
    The treatment of cells with histone deacetylase inhibitors (HDACi) was reported to reveal the acetylation of STAT1 at lysine 410 and lysine 413 (O. H. Krämer et al., Genes Dev. 20:473-485, 2006)...
  53. Strassheim D, Riddle S, Burke D, Geraci M, Stenmark K. Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner. J Immunol. 2009;183:6981-8 pubmed publisher
    ..We found that activation of STAT1 was critical for IFN-gamma-induced MCP-1 production and demonstrated that iloprost inhibited STAT1 activation by ..
  54. Khodarev N, Ahmad R, Rajabi H, Pitroda S, Kufe T, McClary C, et al. Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. Oncogene. 2010;29:920-9 pubmed publisher
    Signal transducer and activator of transcription 1 (STAT1) is activated in the inflammatory response to interferons. The MUC1 oncoprotein is overexpressed in human breast cancers...
  55. Guzzo C, Che Mat N, Gee K. Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes. J Biol Chem. 2010;285:24404-11 pubmed publisher
    ..Furthermore, we observed that IL-27-induced cytokine and chemokine production was mediated by STAT1, STAT3, and NF-kappaB activation...
  56. Wesoly J, Szweykowska Kulinska Z, Bluyssen H. STAT activation and differential complex formation dictate selectivity of interferon responses. Acta Biochim Pol. 2007;54:27-38 pubmed
    ..In addition, the fact that STAT2 homodimers are not capable of binding consensus GAS sites leaves the possibility for a novel type of DNA-binding site bound by STAT2 homodimers and potentially other STAT complexes. ..
  57. Xin Z, Han W, Zhao Z, Xia Q, Yin B, Yuan J, et al. PCBP2 enhances the antiviral activity of IFN-? against HCV by stabilizing the mRNA of STAT1 and STAT2. PLoS ONE. 2011;6:e25419 pubmed publisher
    ..RIP-qRT-PCR and RNA half-life further revealed that PCBP2 stabilizes the mRNA of STAT1 and STAT2 through binding the 3'Untranslated Region (UTR) of these two molecules, which are pivotal for the IFN-? ..
  58. Pitroda S, Wakim B, Sood R, Beveridge M, Beckett M, Macdermed D, et al. STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect. BMC Med. 2009;7:68 pubmed publisher
    The Signal Transducer and Activator of Transcription 1 (STAT1) has traditionally been regarded as a transmitter of interferon signaling and a pro-apoptotic tumour suppressor...