STAM

Summary

Gene Symbol: STAM
Description: signal transducing adaptor molecule
Alias: STAM-1, STAM1, signal transducing adapter molecule 1, HSE1 homolog, signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Species: human
Products:     STAM

Top Publications

  1. Kikuchi K, Ishii N, Asao H, Sugamura K. Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif. Biochem Biophys Res Commun. 2003;306:637-43 pubmed
    ..However, the present study demonstrated that AMSH-LP, unlike AMSH, fails to bind to the SH3 domains of STAM1 (signal transducing adaptor molecule 1) and Grb2...
  2. Takeshita T, Arita T, Higuchi M, Asao H, Endo K, Kuroda H, et al. STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction. Immunity. 1997;6:449-57 pubmed
    We previously identified a putative signal transducing adaptor molecule, named STAM, that contains an Src homology 3 (SH3) domain and immunoreceptor tyrosine-based activation motif (ITAM)...
  3. Ren X, Hurley J. VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo. EMBO J. 2010;29:1045-54 pubmed publisher
    VHS (Vps27, Hrs, and STAM) domains occur in ESCRT-0 subunits Hrs and STAM, GGA adapters, and other trafficking proteins. The structure of the STAM VHS domain-ubiquitin complex was solved at 2...
  4. Sierra M, Wright M, Nash P. AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4. J Biol Chem. 2010;285:13990-4004 pubmed publisher
    ..inactive mutant of AMSH show basal hyperubiquitination, but not increased degradation, of the ESCRT-0 components STAM1 and Hrs. This is dependent on the RXXK motif of AMSH...
  5. Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, et al. STAM2, a new member of the STAM family, binding to the Janus kinases. FEBS Lett. 2000;477:55-61 pubmed
    ..STAM2 like STAM1 is associated with Jak2 and Jak3, and involved in the signaling for DNA synthesis and c-myc induction mediated by ..
  6. Malik R, Marchese A. Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4. Mol Biol Cell. 2010;21:2529-41 pubmed publisher
    ..Signal-transducing adaptor molecule (STAM)-1, but not related STAM-2, interacts directly with arrestin-2 and colocalizes with CXCR4 on early endosomal ..
  7. McCullough J, Clague M, Urbé S. AMSH is an endosome-associated ubiquitin isopeptidase. J Cell Biol. 2004;166:487-92 pubmed
    ..We have looked for similar activity in associated molecule with the SH3 domain of STAM (AMSH), a JAMM domain-containing protein that associates with the SH3-domain of STAM, a protein, which regulates ..
  8. Rismanchi N, Puertollano R, Blackstone C. STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking. Traffic. 2009;10:201-17 pubmed publisher
    ..In this study, we demonstrate that STAM proteins also localize prominently to early exocytic compartments and profoundly regulate Golgi morphology...
  9. Bache K, Raiborg C, Mehlum A, Stenmark H. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. J Biol Chem. 2003;278:12513-21 pubmed
    b>STAM1 and STAM2, which have been identified as regulators of receptor signaling and trafficking, interact directly with Hrs, which mediates the endocytic sorting of ubiquitinated membrane proteins...

More Information

Publications98

  1. Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, et al. Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. Biochem Biophys Res Commun. 1996;225:1035-9 pubmed
    We molecularly cloned a cDNA coding for a novel phosphotyrosine molecule with a 70 kDa molecular mass, named STAM (signal transducing adaptor molecule), which is tyrosine-phosphorylated rapidly after stimulation with various cytokines ..
  2. Kanazawa C, Morita E, Yamada M, Ishii N, Miura S, Asao H, et al. Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation. Biochem Biophys Res Commun. 2003;309:848-56 pubmed
    The STAM family proteins, STAM1 and STAM2/EAST/Hbp, are phosphotyrosine proteins that contain SH3 domains and ubiquitin-interacting motifs...
  3. Malik R, Soh U, Trejo J, Marchese A. Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. J Biol Chem. 2012;287:9013-27 pubmed publisher
    ..CXCR4 sorting is regulated by an interaction between endosomal localized arrestin-2 and STAM-1, an ESCRT-0 component...
  4. Kato M, Miyazawa K, Kitamura N. A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP. J Biol Chem. 2000;275:37481-7 pubmed
    ..Ubiquitination of growth factor receptors is thought to regulate their intracellular degradation. Thus, UBPY may play a regulatory role in the degradation by interaction with the SH3 domain of Hbp via the novel SH3-binding motif. ..
  5. McCullough J, Row P, Lorenzo O, Doherty M, Beynon R, Clague M, et al. Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. Curr Biol. 2006;16:160-5 pubmed
    ..It directly binds to the SH3 domain of STAM, which is constitutively associated with Hrs, a component of clathrin-coated structures on endosomes...
  6. Row P, Prior I, McCullough J, Clague M, Urbé S. The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. J Biol Chem. 2006;281:12618-24 pubmed
    ..In contrast, stability of the UBPY binding partner STAM is dramatically compromised in UBPY knockdown cells...
  7. Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, et al. Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth. J Biol Chem. 1997;272:32785-91 pubmed
    We previously reported a new type of signal-transducing adaptor molecule, STAM, which was shown to be involved in cytokine-mediated intracellular signal transduction...
  8. Ren X, Kloer D, Kim Y, Ghirlando R, Saidi L, Hummer G, et al. Hybrid structural model of the complete human ESCRT-0 complex. Structure. 2009;17:406-16 pubmed publisher
    The human Hrs and STAM proteins comprise the ESCRT-0 complex, which sorts ubiquitinated cell surface receptors to lysosomes for degradation...
  9. Tanaka N, Kaneko K, Asao H, Kasai H, Endo Y, Fujita T, et al. Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines. J Biol Chem. 1999;274:19129-35 pubmed
    b>STAM containing an SH3 (Src homology 3) domain and an immunoreceptor tyrosine-based activation motif was previously revealed to be implicated in signaling pathways immediately downstream of Jak2 and Jak3 tyrosine kinases associated with ..
  10. Huang F, Zeng X, Kim W, Balasubramani M, Fortian A, Gygi S, et al. Lysine 63-linked polyubiquitination is required for EGF receptor degradation. Proc Natl Acad Sci U S A. 2013;110:15722-7 pubmed publisher
    ..enzyme AMSH [associated molecule with the Src homology 3 domain of signal transducing adaptor molecule (STAM)] was fused to the carboxyl terminus of EGFR, was generated...
  11. Park J, Mok J, Han Y, Park T, Kang K, Choi C, et al. Connectivity mapping of angiotensin-PPAR interactions involved in the amelioration of non-alcoholic steatohepatitis by Telmisartan. Sci Rep. 2019;9:4003 pubmed publisher
    ..In the present study, diabetic nonalcoholic steatohepatitis (NASH) mice (STAM mice) received daily administrations of telmisartan for 6 weeks to assess the improvements in NASH...
  12. Ribeiro Rodrigues T, Catarino S, Marques C, Ferreira J, Martins Marques T, Pereira P, et al. AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions. FASEB J. 2014;28:4629-41 pubmed publisher
    ..Here we report that the DUB-associated molecule with the SH3 domain of STAM (AMSH) interacts with Cx43 and mediates its deubiquitination...
  13. McDonell L, Mirzaa G, Alcantara D, Schwartzentruber J, Carter M, Lee L, et al. Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome. Nat Genet. 2013;45:556-62 pubmed publisher
    ..and identified recessive mutations in STAMBP, a gene encoding the deubiquitinating (DUB) isopeptidase STAMBP (STAM-binding protein, also known as AMSH, associated molecule with the SH3 domain of STAM) that has a key role in cell ..
  14. Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Nagashima Y, et al. Lipid-lowering agents inhibit hepatic steatosis in a non-alcoholic steatohepatitis-derived hepatocellular carcinoma mouse model. Eur J Pharmacol. 2016;772:22-32 pubmed publisher
    ..of NAFLD and tumorigenesis in a non-alcoholic steatohepatitis-derived hepatocellular carcinoma model mouse (STAM mice) generated by streptozotocin injection and a high-fat diet...
  15. El Dessouky H, Aziz A, Sheikhany A, ElMeshmeshy L. Validation of the Egyptian Arabic Assessment of Auditory Skills development using children with Cochlear Implants. Int J Pediatr Otorhinolaryngol. 2019;122:52-59 pubmed publisher
    ..Regarding the Short Term Auditory Memory (STAM) domain scores and the Supra-segmental Discrimination (SSD) domain scores there was significant difference between ..
  16. Lavorgna A, Harhaj E. An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation. J Virol. 2012;86:3357-69 pubmed publisher
    ..screening a deubiquitinating (DUB) enzyme small interfering RNA (siRNA) library, we identified the metalloprotease STAM-binding protein-like 1 (STAMBPL1) as a positive regulator of Tax-mediated NF-κB activation...
  17. Middleton S, Rajpal N, Cutler L, Mander P, Rioja I, Prinjha R, et al. BET Inhibition Improves NASH and Liver Fibrosis. Sci Rep. 2018;8:17257 pubmed publisher
    ..this hypothesis, we tested a small-molecule inhibitor of the BET family of proteins, GSK1210151A (I-BET151), in the STAM mouse NASH model at two different dosing timepoints (onset of NASH and progression to fibrosis)...
  18. Parsons L, Portela M, Grzeschik N, Richardson H. Lgl regulates Notch signaling via endocytosis, independently of the apical aPKC-Par6-Baz polarity complex. Curr Biol. 2014;24:2073-2084 pubmed publisher
    ..in lgl- tissue requires dynamin- and Rab5-mediated endocytosis and vesicle acidification but is independent of Hrs/Stam or Rab11 activity...
  19. Shahriyar S, Woo S, Seo S, Min K, Kwon T. Cepharanthine Enhances TRAIL-Mediated Apoptosis Through STAMBPL1-Mediated Downregulation of Survivin Expression in Renal Carcinoma Cells. Int J Mol Sci. 2018;19: pubmed publisher
    ..Interestingly, CEP induced survivin downregulation through downregulation of deubiquitin protein of STAM-binding protein-like 1 (STAMBPL1)...
  20. Yoshida Y, Furukawa J, Naito S, Higashino K, Numata Y, Shinohara Y. Identification of unique glycoisoforms of vitamin D-binding protein and haptoglobin as biomarker candidates in hepatocarcinogenesis of STAM mice. Glycoconj J. 2018;35:467-476 pubmed publisher
    ..Furthermore, these glycan increases were not observed in age-matched control mice. In conclusion, our approach has identified specific glycan marker candidates for the early diagnosis of HCC. ..
  21. Dow M, Pyke R, Tsui B, Alexandrov L, Nakagawa H, Taniguchi K, et al. Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2018;115:E9879-E9888 pubmed publisher
    ..mouse models [MUP transgenic, TAK1-knockout, carcinogen-driven diethylnitrosamine (DEN), and Stelic Animal Model (STAM)] with those of 987 HCC patients with distinct etiologies...
  22. Sheng Z, Yu L, Zhang T, Pei X, Li X, Zhang Z, et al. ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling. J Cell Sci. 2016;129:2075-84 pubmed publisher
    ..we identified synthetic lethal interactions between mutations of fly Rb (rbf) and the ESCRT-0 components stam and hrs We show that inactivation of ESCRT-0 sensitizes rbf-mutant cells to undergo apoptosis through inhibition of ..
  23. Gschweitl M, Ulbricht A, Barnes C, Enchev R, Stoffel Studer I, Meyer Schaller N, et al. A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes. elife. 2016;5:e13841 pubmed publisher
    ..by CUL3-SPOPL as EPS15, an endocytic adaptor that also associates with the ESCRT-0 complex members HRS and STAM on endosomes...
  24. Kenney S, Meng X. An SH3 binding motif within the nucleocapsid protein of porcine reproductive and respiratory syndrome virus interacts with the host cellular signaling proteins STAMI, TXK, Fyn, Hck, and cortactin. Virus Res. 2015;204:31-9 pubmed publisher
    ..Subsequently, we identified five host cellular proteins [signal transducing adaptor molecule (STAM)I, TXK tyrosine kinase (TXK), protein tyrosine kinase fyn (Fyn), hematopoietic cell kinase (Hck), and cortactin] ..
  25. Birol M, Echalier A. Structure and function of MPN (Mpr1/Pad1 N-terminal) domain-containing proteins. Curr Protein Pept Sci. 2014;15:504-17 pubmed
    ..multi-protein complex have also been reported and include AMSH (for associated molecule with the SH3 domain of STAM) and the AMSH-Like Protein (AMSH-LP)...
  26. Takaki Y, Saito Y, Takasugi A, Toshimitsu K, Yamada S, Muramatsu T, et al. Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis. Cancer Sci. 2014;105:1254-60 pubmed publisher
    ..mechanism underlying hepatocarcinogenesis from NASH, microRNA (miRNA) expression profiles were analyzed in STAM mice, a NASH-HCC animal model. MicroRNA expression was also examined in 42 clinical samples of HCC tissue...
  27. Hori I, Miya F, Negishi Y, Hattori A, Ando N, Boroevich K, et al. A novel homozygous missense mutation in the SH3-binding motif of STAMBP causing microcephaly-capillary malformation syndrome. J Hum Genet. 2018;63:957-963 pubmed publisher
    ..STAMBP interacts with the SH3 domain of STAM and transduces downstream signals from the Jaks-STAM complex...
  28. Pais P, D Amato M. In vivo efficacy study of milk thistle extract (ETHIS-094â„¢) in STAMâ„¢ model of nonalcoholic steatohepatitis. Drugs R D. 2014;14:291-9 pubmed publisher
    ..The current study was undertaken to examine the effects of ETHIS-094â„¢ in the Stelic Animal Model (STAMâ„¢), a validated and widely used animal model for NASH...
  29. Yoshida Y, Furukawa J, Naito S, Higashino K, Numata Y, Shinohara Y. Quantitative analysis of total serum glycome in human and mouse. Proteomics. 2016;16:2747-2758 pubmed publisher
    ..Furthermore, total serum glycomics of STAM mouse were unveiled as an initial step to identify novel biomarkers of liver diseases, with which we could identify ..
  30. Prag G, Watson H, Kim Y, Beach B, Ghirlando R, Hummer G, et al. The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting. Dev Cell. 2007;12:973-86 pubmed
    The yeast Vps27/Hse1 complex and the homologous mammalian Hrs/STAM complex deliver ubiquitinated transmembrane proteins to the ESCRT endosomal-sorting pathway...
  31. Takakura K, Koido S, Fujii M, Hashiguchi T, Shibazaki Y, Yoneyama H, et al. Characterization of non-alcoholic steatohepatitis-derived hepatocellular carcinoma as a human stratification model in mice. Anticancer Res. 2014;34:4849-55 pubmed
    ..Herein we showed that the recently-reported, non-alcoholic steatohepatitis-derived HCC model (STAM model) is the first murine model in which the concept of human stratification is applicable by demonstrating the ..
  32. Reppermund S, Birch R, Crawford J, Wesson J, Draper B, Kochan N, et al. Performance-Based Assessment of Instrumental Activities of Daily Living: Validation of the Sydney Test of Activities of Daily Living in Memory Disorders (STAM). J Am Med Dir Assoc. 2017;18:117-122 pubmed publisher
    ..validated a performance-based measure of IADL, the Sydney Test of Activities of Daily Living in Memory Disorders (STAM). Prospective cohort study (Sydney Memory and Ageing Study). Eastern Suburbs, Sydney, Australia...
  33. Bednash J, Weathington N, Londino J, Rojas M, Gulick D, Fort R, et al. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. Nat Commun. 2017;8:15203 pubmed publisher
    ..With TLR ligation, the deubiquitinase enzyme, STAM-binding protein (STAMBP) impedes NALP7 trafficking to lysosomes to increase NALP7 abundance...
  34. Dejarnac O, Hafirassou M, Chazal M, Versapuech M, Gaillard J, Perera Lecoin M, et al. TIM-1 Ubiquitination Mediates Dengue Virus Entry. Cell Rep. 2018;23:1779-1793 pubmed publisher
    ..Furthermore, STAM-1, a component of the ESCRT-0 complex involved in intracellular trafficking of ubiquitinated cargos, interacts with ..
  35. Kakehashi A, Stefanov V, Ishii N, Okuno T, Fujii H, Kawai K, et al. Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas. Int J Mol Sci. 2017;18: pubmed publisher
    ..In addition, proteome analysis of liver tumors in male STAM NASH-model mice was performed...
  36. Yoshimine Y, Uto H, Kumagai K, Mawatari S, Arima S, Ibusuki R, et al. Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis. Oncol Rep. 2015;33:1657-66 pubmed publisher
    ..involved in NASH progression by analysis of pathophysiological features and gene-expression profiles in livers of STAM mice, a model of NASH-associated hepatocarcinogenesis...
  37. Takahashi H, Mayers J, Wang L, Edwardson J, Audhya A. Hrs and STAM function synergistically to bind ubiquitin-modified cargoes in vitro. Biophys J. 2015;108:76-84 pubmed publisher
    ..Moreover, we show that the ubiquitin-binding domains in both Hrs and STAM must be intact to enable cargo binding...
  38. Lopez Mongil R. [Cognitive impairment/dementia: assessment and follow-up. Functional aspects]. Rev Esp Geriatr Gerontol. 2017;52 Suppl 1:28-33 pubmed publisher
    ..instrumental and basic, with emphasis on the Sydney Test of Activities of Daily Living in Memory Disorders (STAM) and Mongil's tests of activities of daily living...
  39. Lau E, Lo J, Cheng B, Ma M, Lee J, Ng J, et al. Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling. Cell Rep. 2016;15:1175-89 pubmed publisher
    ..Further functional analysis identifies HEY1 as a direct downstream effector of FRA1. Using the STAM NASH-HCC mouse model, we find that HGF-induced FRA1 activation is associated with the fibrosis-dependent ..
  40. Kawaguchi K, Endo A, Fukushima T, Madoka Y, Tanaka T, Komada M. Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion. Biochem Biophys Res Commun. 2018;499:635-641 pubmed publisher
    ..The interaction was mediated by the adaptor protein STAM1. USP8 overexpression inhibited the formation of large COPII carriers...
  41. Ma H, Wardega P, Mazaud D, Klosowska Wardega A, Jurek A, Engstrom U, et al. Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation. Cell Signal. 2015;27:2209-19 pubmed publisher
    ..Furthermore, the levels of STAM and Hrs of the ESCRT0 machinery were decreased, and immunofluorescence staining showed that in HD-PTP-depleted ..
  42. Gomez Lamarca M, Snowdon L, Seib E, Klein T, Bray S. Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling. J Cell Biol. 2015;210:303-18 pubmed publisher
    ..Likewise, depletion of ESCRT-0 components Hrs or Stam in combination with Rme-8 also led to high levels of ectopic Notch activity...
  43. Kalinowska K, Nagel M, Goodman K, Cuyas L, Anzenberger F, Alkofer A, et al. Arabidopsis ALIX is required for the endosomal localization of the deubiquitinating enzyme AMSH3. Proc Natl Acad Sci U S A. 2015;112:E5543-51 pubmed publisher
    ..Associated molecule with the SH3 domain of signal transduction adaptor molecule (STAM) (AMSH) is a conserved metalloprotease DUB in eukaryotes...
  44. Campos Parra A, Padua Bracho A, Pedroza Torres A, Figueroa González G, Fernandez Retana J, Millan Catalan O, et al. Comprehensive transcriptome analysis identifies pathways with therapeutic potential in locally advanced cervical cancer. Gynecol Oncol. 2016;143:406-413 pubmed publisher
    ..We confirmed the overexpression of the relevant genes of each pathway, such as NOTCH1, JAK2, STAM1, SOS1, ADAM17, PSEN1, NCSTN, RPS6, STK11/LKB1 and MLTS8/GBL in LACC compared with normal cervical tissue epithelia...
  45. Ellena J, Xiong W, Zhao X, Shanaiah N, Capelluto D. Backbone 1H, 15N, and 13C resonance assignments of the Tom1 VHS domain. Biomol NMR Assign. 2017;11:1-4 pubmed publisher
    ..This phosphoinositide-binding property is associated with its N-terminal Vps27, Hrs, STAM (VHS) domain...
  46. Hologne M, Cantrelle F, Rivière G, Guillière F, Trivelli X, Walker O. NMR Reveals the Interplay among the AMSH SH3 Binding Motif, STAM2, and Lys63-Linked Diubiquitin. J Mol Biol. 2016;428:4544-4558 pubmed publisher
    AMSH [associated molecule with a Src homology 3 domain of signal transducing adaptor molecule (STAM)] is one of the deubiquitinating enzymes associated in the regulation of endocytic cargo trafficking...
  47. Ochodnicky P, Lattenist L, Ahdi M, Kers J, Uil M, Claessen N, et al. Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy. Am J Pathol. 2017;187:1971-1983 pubmed publisher
    ..Renal injury in diabetes is associated with elevated systemic and urine levels of sMer and sTyro3. This is the first study reporting excretion of sTAM receptors in urine, identifying the kidney as a source of sTAM.
  48. Holleman J, Marchese A. The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. Mol Biol Cell. 2014;25:1892-904 pubmed publisher
    ..Therefore we define a novel role for DTX3L in GPCR endosomal sorting and reveal an unprecedented link between two distinct E3 ubiquitin ligases to control the activity of the ESCRT machinery. ..
  49. Alekhina O, Marchese A. ?-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4. J Biol Chem. 2016;291:26083-26097 pubmed
    ..Here, we show that the ?-arrestin1·signal-transducing adaptor molecule 1 (STAM1) complex, initially identified to govern lysosomal trafficking of CXCR4, also mediates CXCR4-dependent chemotaxis...
  50. Baiady N, Padala P, Mashahreh B, Cohen Kfir E, Todd E, Du Pont K, et al. The Vps27/Hrs/STAM (VHS) Domain of the Signal-transducing Adaptor Molecule (STAM) Directs Associated Molecule with the SH3 Domain of STAM (AMSH) Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage. J Biol Chem. 2016;291:2033-42 pubmed publisher
    The deubiquitinating enzyme associated molecule with the SH3 domain of STAM (AMSH) is crucial for the removal of ubiquitin molecules during receptor-mediated endocytosis and lysosomal receptor sorting...
  51. Nam H, Lee S. Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons. Development. 2016;143:2334-43 pubmed publisher
    ..b>STAM1 and HRS form a complex involved with endosomal targeting of cargo proteins, including the chemokine receptor CXCR4...
  52. Luo S, Jing L, Zhao T, Li Y, Liu Z, Diao A. Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking. Sci Rep. 2017;7:42668 pubmed publisher
    ..Moreover, TMEPAI binds the ubiquitin binding proteins Hrs and STAM which is required for its lysosomal transport...
  53. Bränn E, Papadopoulos F, Fransson E, White R, Edvinsson A, Hellgren C, et al. Inflammatory markers in late pregnancy in association with postpartum depression-A nested case-control study. Psychoneuroendocrinology. 2017;79:146-159 pubmed publisher
    ..The difference remained statistically significant for STAM-BP (or otherwise AMSH), AXIN-1, ADA, ST1A1 and IL-10, after Bonferroni correction...
  54. Balek L, Nemec P, Konik P, Kunova Bosakova M, Varecha M, Gudernová I, et al. Proteomic analyses of signalling complexes associated with receptor tyrosine kinase identify novel members of fibroblast growth factor receptor 3 interactome. Cell Signal. 2018;42:144-154 pubmed publisher
    ..Using co-immunoprecipitations, we validated FGFR3 interaction with adapter protein STAM1, transcriptional regulator SHOX2, translation elongation factor eEF1A1, serine/threonine kinases ICK, MAK and CCRK,..
  55. Agromayor M, Martin Serrano J. Interaction of AMSH with ESCRT-III and deubiquitination of endosomal cargo. J Biol Chem. 2006;281:23083-91 pubmed
    ..Here we report the interaction of AMSH (associated molecule with the SH3 domain of STAM), an endosomal deubiquitinating enzyme, with the endodomal sorting complex required for transport (ESCRT-III) ..
  56. Mizuno E, Kobayashi K, Yamamoto A, Kitamura N, Komada M. A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes. Traffic. 2006;7:1017-31 pubmed
    ..The Hrs-STAM complex, a class E Vps protein complex essential for the initial step of the sorting pathway, binds two ..
  57. Liu M, Shi D, Li J. Double-edged sword of interdisciplinary knowledge flow from hard sciences to humanities and social sciences: Evidence from China. PLoS ONE. 2017;12:e0184977 pubmed publisher
    ..e., Science, Technology, Agriculture and Medicine (STAM), as testified by a growing number of citations...
  58. Kobayashi H, Tanaka N, Asao H, Miura S, Kyuuma M, Semura K, et al. Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2. J Biol Chem. 2005;280:10468-77 pubmed
    ..In the hrs(-/-) cells only trace amounts of STAM1 and STAM2 were detected...
  59. Chen L, Chen R, Kemper S, Brigstock D. Pathways of production and delivery of hepatocyte exosomes. J Cell Commun Signal. 2018;12:343-357 pubmed publisher
    ..intracellular vesicle trafficking (Rab 5a,b,c, Rab 7a, Rab 27a,b) or exosome biogenesis via the ESCRT (HGS, Alix, STAM1, TSG101, VTA1, YKT6) or ceramide (nSmase2) pathways...
  60. Blackstone C, Roberts R, Seeburg D, Sheng M. Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1. Biochem Biophys Res Commun. 2003;305:345-52 pubmed
    ..b>STAM1 is a cytoplasmic signal-transducing adaptor molecule implicated in cytokine signaling...
  61. Takatsu H, Katoh Y, Shiba Y, Nakayama K. Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains. J Biol Chem. 2001;276:28541-5 pubmed
    ..and subsequent two-hybrid and pull-down analyses, we have shown that GGA proteins, through their VHS (Vps27p/Hrs/STAM) domains, interact with acidic dileucine sequences found in the cytoplasmic domains of TGN-localized sorting ..
  62. Lu M, Zhang L, Sartippour M, Norris A, Brooks M. EG-1 interacts with c-Src and activates its signaling pathway. Int J Oncol. 2006;29:1013-8 pubmed
    ..Furthermore, EG-1 shows interaction with multiple other SH3- and WW-containing molecules involved in various signaling pathways. These observations suggest that EG-1 may be involved in signaling pathways including c-Src activation. ..
  63. Kim M, Kim J, Song H, Jeon H. STAM-AMSH interaction facilitates the deubiquitination activity in the C-terminal AMSH. Biochem Biophys Res Commun. 2006;351:612-8 pubmed
    Signal transducing adaptor molecule (STAM) complexed with hepatocyte growth factor regulated tyrosine kinase substrate (Hrs) works on sorting of cargo proteins in multivesicular body (MVB) pathway...
  64. Seet B, Berry D, Maltzman J, Shabason J, Raina M, Koretzky G, et al. Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif. EMBO J. 2007;26:678-89 pubmed
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    b>STAM1 and Hrs are the components of ESCRT-0 complex for lysosomal degradation of membrane proteins is composed of STAM1 Hrs and has multiple ubiquitin binding domains...
  66. Kharitidi D, Apaja P, Manteghi S, Suzuki K, Malitskaya E, Roldan A, et al. Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration. Cell Rep. 2015;13:599-609 pubmed publisher
    ..Thus, pH-dependent FN-integrin dissociation and deubiquitination of the activated integrin α5β1 are required for receptor resensitization and cell migration, representing potential targets to modulate tumor invasiveness. ..
  67. Stuible M, Abella J, Feldhammer M, Nossov M, Sangwan V, Blagoev B, et al. PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2. J Biol Chem. 2010;285:23899-907 pubmed publisher
    ..These results reveal a novel link between the dephosphorylation and endocytic machinery and suggest that PTP1B can affect RTK signaling in a previously unrecognized manner. ..
  68. Lim J, Hong Y, Lee B, Ahn H. Backbone 1H, 13C, and 15N assignments for the tandem ubiquitin binding domains of signal transducing adapter molecule 1. Biomol NMR Assign. 2011;5:51-4 pubmed publisher
    ..the backbone resonance assignments and the secondary structure of the N-terminal 191 amino acids of the human STAM1 which includes the VHS domain and UIM...
  69. Tian X, Irannejad R, Bowman S, Du Y, Puthenveedu M, von Zastrow M, et al. The ?-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the ?2-Adrenergic Receptor. J Biol Chem. 2016;291:14510-25 pubmed publisher
    ..Thus, ARRDC3 functions as a switch to modulate the endosomal residence time and subsequent intracellular signaling of the ?2AR. ..
  70. Steen H, Kuster B, Fernandez M, Pandey A, Mann M. Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway. J Biol Chem. 2002;277:1031-9 pubmed
    ..addition to several known tyrosine phosphorylation sites, we have identified five novel sites on SHIP-2, Hrs, Cbl, STAM, and STAM2, most of which were not predicted to be phosphorylated...
  71. Mizuno E, Kawahata K, Okamoto A, Kitamura N, Komada M. Association with Hrs is required for the early endosomal localization, stability, and function of STAM. J Biochem. 2004;135:385-96 pubmed
    Members of the STAM family of proteins, STAM1 and STAM2, are associated with Hrs through their coiled-coil regions...
  72. Kojima K, Amano Y, Yoshino K, Tanaka N, Sugamura K, Takeshita T. ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation. J Biol Chem. 2014;289:33296-310 pubmed publisher
    ..In this study, we have found that co-expressing exogenous STAM1 in Hrs-overexpressing cells leads to a diffuse localization for a large part of the Hrs accumulated on endosomes ..
  73. Row P, Liu H, Hayes S, Welchman R, Charalabous P, Hofmann K, et al. The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. J Biol Chem. 2007;282:30929-37 pubmed
    ..We also show that in common with AMSH, UBPY deubiquitinating enzyme activity can be stimulated by STAM but is unresponsive to its cognate CHMPs...
  74. Fisher R, Wang B, Alam S, Higginson D, Robinson H, Sundquist W, et al. Structure and ubiquitin binding of the ubiquitin-interacting motif. J Biol Chem. 2003;278:28976-84 pubmed
    ..UIM peptides from several proteins involved in endocytosis and vacuolar protein sorting including Hrs, Vps27p, Stam1, and Eps15 bound specifically, but with modest affinity (Kd = 0.1-1 mm), to free ubiquitin...
  75. Mizuno E, Kawahata K, Kato M, Kitamura N, Komada M. STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif. Mol Biol Cell. 2003;14:3675-89 pubmed
    ..Signal-transducing adaptor molecule (STAM) proteins, STAM1 and STAM2, are associated with hepatocyte growth factor-regulated substrate (Hrs) but their function remains ..
  76. Oved S, Mosesson Y, Zwang Y, Santonico E, Shtiegman K, Marmor M, et al. Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases. J Biol Chem. 2006;281:21640-51 pubmed
    ..We discuss the emerging versatility of the concerted action of ubiquitylation and neddylation in the process that desensitizes growth factor-activated receptor tyrosine kinases. ..
  77. Berlin I, Schwartz H, Nash P. Regulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8·STAM complex. J Biol Chem. 2010;285:34909-21 pubmed publisher
    ..RXXK) motifs that specify direct low affinity interactions with the SH3 domain(s) of ESCRT-0 proteins, STAM1/2...
  78. Davies C, PAUL L, Das C. Mechanism of recruitment and activation of the endosome-associated deubiquitinase AMSH. Biochemistry. 2013;52:7818-29 pubmed publisher
    ..The catalytic activity of AMSH is stimulated upon binding to the ESCRT-0 member STAM; however, the precise mechanism and its significance are not known...
  79. Sirisaengtaksin N, Gireud M, Yan Q, Kubota Y, Meza D, Waymire J, et al. UBE4B protein couples ubiquitination and sorting machineries to enable epidermal growth factor receptor (EGFR) degradation. J Biol Chem. 2014;289:3026-39 pubmed publisher
    ..We propose a model in which the coordinated action of UBE4B, ESCRT-0, and the deubiquitinating enzyme USP8 enable the endosomal sorting and lysosomal degradation of the EGFR. ..
  80. Saito T, Muramatsu M, Ishii Y, Saigo Y, Konuma T, Toriniwa Y, et al. Pathophysiological analysis of the progression of hepatic lesions in STAM mice. Physiol Res. 2017;66:791-799 pubmed
    ..In this study, we investigated the pathophysiological changes observed in hepatic lesions in STAM mice, a novel NASH model...
  81. Colombo M, Moita C, van Niel G, Kowal J, Vigneron J, Benaroch P, et al. Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. J Cell Sci. 2013;126:5553-65 pubmed publisher
    ..Silencing of HRS, STAM1 or TSG101 reduced the secretion of EV-associated CD63 and MHC II but each gene altered differently the size and/or ..
  82. Wijesuriya T, De Ceuninck L, Masschaele D, Sanderson M, Carias K, Tavernier J, et al. The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways. Hum Mol Genet. 2017;26:4215-4230 pubmed publisher
    ..had less LepR and altered levels of ubiquitin pathway proteins that regulate LepR processing (Rnf41, Usp8, and Stam1). MAGEL2 increased the cell surface abundance of LepR and decreased their degradation...
  83. Row P, Clague M, Urbé S. Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties. Biochem J. 2005;389:629-36 pubmed
    Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (signal-transducing adaptor molecule) form a heterodimeric complex that associates with endosomal membranes and is tyrosine-phosphorylated in response to a ..
  84. Nakamura M, Tanaka N, Kitamura N, Komada M. Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes. Genes Cells. 2006;11:593-606 pubmed
    ..membrane proteins for trafficking to lysosomes is executed by a complex of two ubiquitin-binding proteins, Hrs and STAM, that localizes on a microdomain of early endosomes with a flat clathrin coat...
  85. Hong Y, Ahn H, Lim J, Kim H, Ji H, Lee S, et al. Identification of a novel ubiquitin binding site of STAM1 VHS domain by NMR spectroscopy. FEBS Lett. 2009;583:287-92 pubmed publisher
    Interaction between the signal-transducing adapter molecule 1 (STAM1) Vps27/Hrs/Stam (VHS) domain and ubiquitin was investigated by nuclear magnetic resonance (NMR) spectroscopy...
  86. Zhang M, Veselits M, O Neill S, Hou P, Reddi A, Berlin I, et al. Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor. J Immunol. 2007;179:4435-43 pubmed
    ..However, they also reveal that E3 ligases play a broader role in multiple processes that determine the fate of Ag-engaged BCR complexes. ..
  87. Luo X, Pan J, Wang L, Wang P, Zhang M, Liu M, et al. Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes. BMC Pregnancy Childbirth. 2015;15:35 pubmed publisher
    ..Differential expression of the transcripts PPP2R5C, STAM, TACC2, EML4, PAM, PDE4B, STAM, PPP2R5C, PDE4B, and EGFR indicated a co-expression among these mRNAs, which are ..
  88. Sundd M. Conformational and dynamic changes at the interface contribute to ligand binding by ubiquitin. Biochemistry. 2012;51:8111-24 pubmed publisher
    ..Taken together, our studies provide an in-depth view of the molecular changes associated with ligand recognition by ubiquitin. ..
  89. de Conti A, Ortega J, Tryndyak V, Dreval K, Moreno F, Rusyn I, et al. MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis. Oncotarget. 2017;8:88517-88528 pubmed publisher
    ..In the present study, using liver samples from C57BL/6J mice submitted to the Stelic Animal Model (STAM) of NASH-associated liver carcinogenesis, we investigated the role of microRNA (miRNA) alterations in the ..