Gene Symbol: STAG2
Description: stromal antigen 2
Alias: SA-2, SA2, SCC3B, bA517O1.1, cohesin subunit SA-2, SCC3 homolog 2
Species: human
Products:     STAG2

Top Publications

  1. Gandhi R, Gillespie P, Hirano T. Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Curr Biol. 2006;16:2406-17 pubmed
    ..Wapl is a new regulator of sister chromatid resolution and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits. ..
  2. Kueng S, Hegemann B, Peters B, Lipp J, Schleiffer A, Mechtler K, et al. Wapl controls the dynamic association of cohesin with chromatin. Cell. 2006;127:955-67 pubmed
    ..Wapl depletion also increases the residence time of cohesin on chromatin in interphase. Our data indicate that Wapl is required to unlock cohesin from a particular state in which it is stably bound to chromatin. ..
  3. Holzmann J, Fuchs J, Pichler P, Peters J, Mechtler K. Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads. J Proteome Res. 2011;10:780-9 pubmed publisher
    ..Furthermore, using isoform specific reference peptides, we determined the exact STAG1:STAG2 stoichiometry within the population of cohesin complexes...
  4. Tarnowski L, Kowalec P, Milewski M, Jurek M, Plochocka D, Fronk J, et al. Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae. PLoS ONE. 2012;7:e38740 pubmed publisher
    ..The two SA paralogues, SA1 and SA2, show some specificity towards the chromosome region they stabilize, and SA2, but not SA1, has been shown to ..
  5. Balbás Martínez C, Sagrera A, Carrillo de Santa Pau E, Earl J, Márquez M, Vazquez M, et al. Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. Nat Genet. 2013;45:1464-9 pubmed publisher this tumor coding for proteins involved in chromatin modification (MLL2, ASXL2 and BPTF), cell division (STAG2, SMC1A and SMC1B) and DNA repair (ATM, ERCC2 and FANCA)...
  6. Lara Pezzi E, Pezzi N, Prieto I, Barthelemy I, Carreiro C, Martinez A, et al. Evidence of a transcriptional co-activator function of cohesin STAG/SA/Scc3. J Biol Chem. 2004;279:6553-9 pubmed
    ..Here we describe STAG/Scc3, which may act as a transcriptional co-activator. STAG2 is able to enhance the activity of the tumor necrosis factor alpha, the CD69, and the human immunodeficiency virus ..
  7. Wu N, Kong X, Ji Z, Zeng W, Potts P, Yokomori K, et al. Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl. Genes Dev. 2012;26:1473-85 pubmed publisher
    ..We propose that Scc1 sumoylation by Mms21 promotes SCR by antagonizing Wapl at a step after cohesin loading at DSBs and in a way not solely dependent on Smc3 acetylation. ..
  8. Liu H, Rankin S, Yu H. Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis. Nat Cell Biol. 2013;15:40-9 pubmed publisher
    ..PP2A-orchestrated, site-selective dephosphorylation of cohesin and its regulators underlies centromeric cohesion protection. ..
  9. Carramolino L, Lee B, Zaballos A, Peled A, Barthelemy I, Shav Tal Y, et al. SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. Gene. 1997;195:151-9 pubmed
    ..The SA-1 gene described in this study is highly conserved between mouse and man. This implies a crucial function for this protein. ..

More Information

Publications118 found, 100 shown here

  1. Losada A, Yokochi T, Kobayashi R, Hirano T. Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes. J Cell Biol. 2000;150:405-16 pubmed
    ..In a second 12.5S complex (x-cohesin(SA2)), XSMC1, XSMC3, and XRAD21 associate with a different subunit, XSA2...
  2. Sumara I, Vorlaufer E, Gieffers C, Peters B, Peters J. Characterization of vertebrate cohesin complexes and their regulation in prophase. J Cell Biol. 2000;151:749-62 pubmed
    ..Both complexes contain SMC1, SMC3, SCC1, and either one of the yeast Scc3p orthologs SA1 and SA2. SA1 is also a subunit of 14S cohesin in Xenopus...
  3. Canudas S, Houghtaling B, Kim J, Dynek J, Chang W, Smith S. Protein requirements for sister telomere association in human cells. EMBO J. 2007;26:4867-78 pubmed
    ..Our studies indicate that sister telomere association in human cells is mediated by a novel association between a cohesin subunit and components of telomeric chromatin. ..
  4. Zhang N, Panigrahi A, Mao Q, Pati D. Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion. J Biol Chem. 2011;286:41826-37 pubmed publisher
    ..Phosphorylation of cohesin subunit SA2 by polo-like kinase 1 (Plk1) is required for the removal of cohesins at prophase, but how Plk1 is recruited to ..
  5. Kim M, Kim S, Je E, Yoo N, Lee S. Mutational and expressional analyses of STAG2 gene in solid cancers. Neoplasma. 2012;59:524-9 pubmed publisher
    Aneuploidy is frequently observed in cancers and is considered a crucial mechanism in cancer development. STAG2 is a gene that encodes a component of cohesion complex required for normal chromosomal segregation...
  6. Watrin E, Schleiffer A, Tanaka K, Eisenhaber F, Nasmyth K, Peters J. Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Curr Biol. 2006;16:863-74 pubmed
    ..The finding that Caenorhabditis elegans MAU-2 is an ortholog of Scc4 further supports the notion that the Scc2-Scc4 complex is required for developmental processes in metazoans. ..
  7. Xiao T, Wallace J, Felsenfeld G. Specific sites in the C terminus of CTCF interact with the SA2 subunit of the cohesin complex and are required for cohesin-dependent insulation activity. Mol Cell Biol. 2011;31:2174-83 pubmed publisher that the interaction of CTCF with the cohesin complex involves direct contacts between the cohesin subunit SA2 and specific regions of the C-terminal tail of CTCF...
  8. Solomon D, Kim T, Diaz Martinez L, Fair J, Elkahloun A, Harris B, et al. Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science. 2011;333:1039-43 pubmed publisher
    ..A diverse range of tumor types were found to harbor deletions or inactivating mutations of STAG2, a gene encoding a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell ..
  9. Schmitz J, Watrin E, Lenart P, Mechtler K, Peters J. Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase. Curr Biol. 2007;17:630-6 pubmed
    ..Our data indicate that sororin interacts with chromatin-bound cohesin and functions during the establishment or maintenance of cohesion in S or G2 phase, respectively. ..
  10. Canudas S, Smith S. Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells. J Cell Biol. 2009;187:165-73 pubmed publisher
    ..of Smc1, Smc3, Scc1, and Scc3, which in vertebrate cells exists as two closely related homologues (SA1 and SA2)...
  11. Prieto I, Pezzi N, Buesa J, Kremer L, Barthelemy I, Carreiro C, et al. STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis. EMBO Rep. 2002;3:543-50 pubmed
    ..Two members of this family, STAG1/SA1 and STAG2/SA2,double dagger are classified as mitotic cohesins, as they are found in human somatic cells and in Xenopus ..
  12. Hauf S, Roitinger E, Koch B, Dittrich C, Mechtler K, Peters J. Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2. PLoS Biol. 2005;3:e69 pubmed
    ..and Aurora-B are required for this dissociation process, and Plk1 can phosphorylate the cohesin subunits Scc1 and SA2 in vitro, consistent with the possibility that cohesin phosphorylation by Plk1 triggers the dissociation of cohesin ..
  13. McGuinness B, Hirota T, Kudo N, Peters J, Nasmyth K. Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. PLoS Biol. 2005;3:e86 pubmed
    ..Remarkably, expression of a version of Scc3-SA2 whose mitotic phosphorylation sites have been mutated to alanine alleviates the precocious loss of sister chromatid ..
  14. Losada A, Yokochi T, Hirano T. Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts. J Cell Sci. 2005;118:2133-41 pubmed
    ..This idea would explain why cells lacking Pds5 function display rather complex and diverse phenotypes in different organisms. ..
  15. Wendt K, Yoshida K, Itoh T, Bando M, Koch B, Schirghuber E, et al. Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature. 2008;451:796-801 pubmed publisher
    ..We propose that cohesin functions as a transcriptional insulator, and speculate that subtle deficiencies in this function contribute to 'cohesinopathies' such as Cornelia de Lange syndrome. ..
  16. Solomon D, Kim J, Bondaruk J, Shariat S, Wang Z, Elkahloun A, et al. Frequent truncating mutations of STAG2 in bladder cancer. Nat Genet. 2013;45:1428-30 pubmed publisher
    Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive ..
  17. Mullenders J, Aranda Orgilles B, Lhoumaud P, Keller M, Pae J, Wang K, et al. Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms. J Exp Med. 2015;212:1833-50 pubmed publisher
    The cohesin complex (consisting of Rad21, Smc1a, Smc3, and Stag2 proteins) is critically important for proper sister chromatid separation during mitosis...
  18. Mondal G, Stevers M, Goode B, Ashworth A, Solomon D. A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers. Nat Commun. 2019;10:1686 pubmed publisher
    ..Genomic analyses have identified that the cohesin subunit STAG2 is frequently inactivated by mutations in cancer...
  19. Shen C, Kim S, Trousil S, Frederick D, Piris A, Yuan P, et al. Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma. Nat Med. 2016;22:1056-61 pubmed publisher
    ..Here we show that loss of stromal antigen 2 (STAG2) or STAG3, which encode subunits of the cohesin complex, in melanoma cells results in resistance to BRAFi...
  20. Mullenders J, de Jongh E, Brousali A, Roosen M, Blom J, Begthel H, et al. Mouse and human urothelial cancer organoids: A tool for bladder cancer research. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
    ..manipulated with ease, which was exemplified by creating genetic knockouts in the tumor suppressors Trp53 and Stag2. Human bladder cancer organoids can be derived efficiently from both resected tumors and biopsies and cultured and ..
  21. Yuan B, Neira J, Pehlivan D, Santiago Sim T, Song X, Rosenfeld J, et al. Clinical exome sequencing reveals locus heterogeneity and phenotypic variability of cohesinopathies. Genet Med. 2019;21:663-675 pubmed publisher
    ..Candidate or recently reported cohesinopathy genes were supported by de novo SNVs/indels in STAG1 (N = 3), STAG2 (N = 5), PDS5A (N = 1), and WAPL (N = 1), and one inherited SNV in PDS5A...
  22. Lin J, Countryman P, Chen H, Pan H, Fan Y, Jiang Y, et al. Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing. Nucleic Acids Res. 2016;44:6363-76 pubmed publisher
    ..the entrapment of DNA within the tripartite ring (Smc1, Smc3 and Rad21) with enforcement from a fourth subunit (SA1/SA2). Surprisingly, cohesin rings do not play a major role in sister telomere cohesion...
  23. Ding S, Diep J, Feng N, Ren L, Li B, Ooi Y, et al. STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection. Nat Commun. 2018;9:1485 pubmed publisher
    ..dependency factors and novel innate immune regulators of rotavirus (RV) infection, we demonstrate that the loss of STAG2, an important component of the cohesin complex, confers resistance to RV replication in cell culture and human ..
  24. Yuan Q, Song C, Gao L, Zhang H, Yang C, Sheng J, et al. Transcriptome de novo assembly and analysis of differentially expressed genes related to cytoplasmic male sterility in onion. Plant Physiol Biochem. 2018;125:35-44 pubmed publisher
    ..In this study, we analysed the anther microstructure of the onion cytoplasmic male sterile line SA2 and the onion maintainer line SB2...
  25. Galeev R, Baudet A, Kumar P, Rundberg Nilsson A, Nilsson B, Soneji S, et al. Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs. Cell Rep. 2016;14:2988-3000 pubmed publisher
    ..A striking finding was the identification of members of the cohesin complex (STAG2, RAD21, STAG1, and SMC3) among the top 20 genes from the screen...
  26. Yeh C, Coyaud Ã, Bashkurov M, van der Lelij P, Cheung S, Peters J, et al. The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression. Curr Biol. 2015;25:2290-9 pubmed publisher
    ..This cohesion is mediated by the conserved cohesin complex comprised of SMC1, SMC3, SCC1, and either SA1 or SA2 in humans...
  27. Zhang N, Pati D. C-terminus of Sororin interacts with SA2 and regulates sister chromatid cohesion. Cell Cycle. 2015;14:820-6 pubmed publisher
    ..of Sororin, especially the last 12 amino acid (aa) residues, is important for Sororin to bind cohesin core subunit SA2. Deletion of the last 12aa residues not only inhibits the interactions between Sororin and SA2 but also causes ..
  28. Grunewald T, Cidre Aranaz F, Surdez D, Tomazou E, de Alava E, Kovar H, et al. Ewing sarcoma. Nat Rev Dis Primers. 2018;4:5 pubmed publisher
    ..Additional mutations at diagnosis are rare and mainly involve STAG2, TP53 and CDKN2A deletions...
  29. Agelopoulos K, Richter G, Schmidt E, Dirksen U, von Heyking K, Moser B, et al. Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma. Clin Cancer Res. 2015;21:4935-46 pubmed publisher
    ..several recurrently mutated genes at low frequency (ANKRD30A, CCDC19, KIAA0319, KIAA1522, LAMB4, SLFN11, STAG2, TP53, UNC80, ZNF98)...
  30. Gill H, Leung A, Kwong Y. Molecular and Cellular Mechanisms of Myelodysplastic Syndrome: Implications on Targeted Therapy. Int J Mol Sci. 2016;17:440 pubmed publisher
    ..KIT), RAS pathways (KRAS, NRAS, CBL, NF1, PTPN11), DNA repair (ATM, BRCC3, DLRE1C, FANCL), and cohesion complexes (STAG2, CTCF, SMC1A, RAD21)...
  31. Cuadrado A, Remeseiro S, Graña O, Pisano D, Losada A. The contribution of cohesin-SA1 to gene expression and chromatin architecture in two murine tissues. Nucleic Acids Res. 2015;43:3056-67 pubmed publisher
    Cohesin, which in somatic vertebrate cells consists of SMC1, SMC3, RAD21 and either SA1 or SA2, mediates higher-order chromatin organization...
  32. Romanutti C, Gallo Calderón M, Keller L, Mattion N, La Torre J. RT-PCR and sequence analysis of the full-length fusion protein of Canine Distemper Virus from domestic dogs. J Virol Methods. 2016;228:79-83 pubmed publisher
    ..Phylogenetic analysis using the F gene full-length sequences grouped all the Argentinean CDV strains in the SA2 clade. Sequence identity with the Onderstepoort vaccine strain was 89.0-90...
  33. Pishas K, Drenberg C, Taslim C, Theisen E, Johnson K, Saund R, et al. Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response. Mol Cancer Ther. 2018;17:1902-1916 pubmed publisher
    ..Although TP53/STAG2/CDKN2A status and basal KDM1A mRNA and protein levels did not correlate with SP-2509 response, induction of ..
  34. Rodkey E, Winkler M, Bethel C, Pagadala S, Buynak J, Bonomo R, et al. Penam sulfones and β-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition. PLoS ONE. 2014;9:e85892 pubmed publisher
    ..b>SA2-13 was previously synthesized and shown to have a lower k(react) than tazobactam...
  35. Maggi R, Balakrishnan N, Bradley J, Breitschwerdt E. Infection with Bartonella henselae in a Danish family. J Clin Microbiol. 2015;53:1556-61 pubmed publisher
    ..In this study, we provide molecular microbiological evidence of Bartonella henselae genotype San Antonio 2 (SA2) infection in four of six Danish family members, including a child who died of unknown causes at 14 months of age.
  36. Hassani N, Baraket A, Neto E, Lee M, Salvador J, Marco M, et al. Novel strategy for sulfapyridine detection using a fully integrated electrochemical Bio-MEMS: Application to honey analysis. Biosens Bioelectron. 2017;93:282-288 pubmed publisher
    ..quantified through a competitive detection procedure with 5-[4-(amino)phenylsulfonamide]-5-oxopentanoic acid-BSA (SA2-BSA) antigens toward polyclonal antibody (Ab-155)...
  37. Weinberg O, Gibson C, Blonquist T, Neuberg D, Pozdnyakova O, Kuo F, et al. Association of mutations with morphological dysplasia in de novo acute myeloid leukemia without 2016 WHO Classification-defined cytogenetic abnormalities. Haematologica. 2018;103:626-633 pubmed publisher
    ..046] were associated with a higher degree of megakaryocytic dysplasia and STAG2 mutations were marginally associated with greater myeloid lineage dysplasia (q=0.052)...
  38. Rad Malekshahi M, Flement M, Hennink W, Mastrobattista E. Optimization of the recombinant production and purification of a self-assembling peptide in Escherichia coli. Microb Cell Fact. 2014;13:178 pubmed publisher
    ..We have shown that the self-assembling peptide SA2 (Ac-AAVVLLLWEE) can be recombinantly produced in E...
  39. Molenaar R, Thota S, Nagata Y, Patel B, Clemente M, Przychodzen B, et al. Clinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasms. Leukemia. 2015;29:2134-42 pubmed publisher
    ..spectra with more DNMT3A and NPM1 mutations associated with IDH1(MT) cases, and more ASXL1, SRSF2, RUNX1, STAG2 mutations associated with IDH2(MT) cases...
  40. Lindsley R, Mar B, Mazzola E, Grauman P, Shareef S, Allen S, et al. Acute myeloid leukemia ontogeny is defined by distinct somatic mutations. Blood. 2015;125:1367-76 pubmed publisher
    ..The presence of a mutation in SRSF2, SF3B1, U2AF1, ZRSR2, ASXL1, EZH2, BCOR, or STAG2 was >95% specific for the diagnosis of s-AML...
  41. Duan Y, Wang Y, Zhang J, Sun Y, Wang J. Dietary effects of succinic acid on the growth, digestive enzymes, immune response and resistance to ammonia stress of Litopenaeus vannamei. Fish Shellfish Immunol. 2018;78:10-17 pubmed publisher
    ..The shrimps were firstly fed with diets containing different levels of SA: 0% (Control), 0.25% (SA1), 0.50% (SA2), and 1.0% (SA3) (w/w) for 56 days, followed by an acute ammonia stress for 48?h...
  42. Kumar R, Corbett M, van Bon B, Gardner A, Woenig J, Jolly L, et al. Increased STAG2 dosage defines a novel cohesinopathy with intellectual disability and behavioral problems. Hum Mol Genet. 2015;24:7171-81 pubmed publisher
    ..The critical overlapping region involved the STAG2 gene, which codes for a subunit of the cohesin complex that regulates cohesion of sister chromatids and gene ..
  43. Blatt S, Pabst A, Schiegnitz E, Hosang M, Ziebart T, Walter C, et al. Early cell response of osteogenic cells on differently modified implant surfaces: Sequences of cell proliferation, adherence and differentiation. J Craniomaxillofac Surg. 2018;46:453-460 pubmed publisher
    ..titanium with rough and hydrophilised surfaces (acid etched titanium (A), sandblasted acid etched titanium (SA and SA2), sandblasted acid etched hydrophilised (SAH), titanium plasma painted titanium (TPS)), titanium with calcium ..
  44. Wolf P, Cuba Ramos A, Kenzel J, Neumann B, Stemmann O. Studying meiotic cohesin in somatic cells reveals that Rec8-containing cohesin requires Stag3 to function and is regulated by Wapl and sororin. J Cell Sci. 2018;131: pubmed publisher
    ..When expressed in Hek293 cells, the kleisin Rec8 displays no affinity for the peripheral cohesin subunits Stag1 or Stag2 and remains cytoplasmic...
  45. Torok M, Konings P, Batterham P, Christensen H. Spatial clustering of fatal, and non-fatal, suicide in new South Wales, Australia: implications for evidence-based prevention. BMC Psychiatry. 2017;17:339 pubmed publisher
    ..intentional self-harm, provided through the NSW Health Admitted Patient Data Collection at a Statistical Area 2 (SA2) geography...
  46. Qiu Z, Song C, Malakouti N, Murray D, Hariz A, Zimmerman M, et al. Functional interactions between NURF and Ctcf regulate gene expression. Mol Cell Biol. 2015;35:224-37 pubmed publisher
    ..because Bptf occupies Ctcf binding sites in vivo and has physical interactions with CTCF and the cohesin subunit SA2. Assays of several Ctcf binding sites using reporter assays showed that their regulatory activity requires Bptf in ..
  47. Gyorffy B, Pongor L, Bottai G, Li X, Budczies J, Szabo A, et al. An integrative bioinformatics approach reveals coding and non-coding gene variants associated with gene expression profiles and outcome in breast cancer molecular subtypes. Br J Cancer. 2018;118:1107-1114 pubmed publisher
    ..signatures associated with three coding mutations (CDH1, MAP3K1 and TP53) and two non-coding variants (CRTC3 and STAG2) in cancer-related genes predicted prognosis in ER-positive/HER2-negative tumours...
  48. Agnew Crumpton R, Vaz P, Devlin J, O Rourke D, Blacker Smith H, Konsak Ilievski B, et al. Spread of the newly emerging infectious laryngotracheitis viruses in Australia. Infect Genet Evol. 2016;43:67-73 pubmed publisher
    ..viruses were found to emerge as a result of recombination between previously existing live vaccine strains (SA2 and A20), and another live vaccine strain (Serva) introduced into the country in 2007...
  49. Mannini L, Cucco F, Quarantotti V, Amato C, Tinti M, Tana L, et al. SMC1B is present in mammalian somatic cells and interacts with mitotic cohesin proteins. Sci Rep. 2015;5:18472 pubmed publisher
    ..maintenance of chromosome proteins, SMC1A and SMC3, the kleisin protein RAD21 and a fourth subunit either STAG1 or STAG2. Meiotic paralogs in mammals were reported for SMC1A, RAD21 and STAG1/STAG2 and are called SMC1B, REC8 and STAG3 ..
  50. Wang S, Chen N, Capodiferro M, Zhang T, Lancioni H, Zhang H, et al. Whole Mitogenomes Reveal the History of Swamp Buffalo: Initially Shaped by Glacial Periods and Eventually Modelled by Domestication. Sci Rep. 2017;7:4708 pubmed publisher
    ..During the late Holocene optimum (11-6 Kya) lineages differentiated further, and at least eight matrilines (SA1, SA2, SB1a, SB1b, SB2a, SB2b, SB3 and SB4) were domesticated around 7-3 Kya...
  51. Kim J, He X, Orr B, Wutz G, Hill V, Peters J, et al. Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2. PLoS Genet. 2016;12:e1005865 pubmed publisher
    Somatic mutations of the cohesin complex subunit STAG2 are present in diverse tumor types...
  52. Zheng X, Zhai G, Gao W, Lei Y, Yu L, Zhu C. Photoisomerization mechanisms from trans, trans-1,4-diphenyl-1,3-butadiene: CASSCF on-the-fly trajectory surface hopping dynamic simulations. Phys Chem Chem Phys. 2016;18:8971-9 pubmed publisher
    We have employed the SA2-CAS(4,4)/6-31G ab initio method together with an on-the-fly global-switching trajectory surface hopping algorithm to simulate photoisomerization reaction dynamics from reactant trans, trans-1,4-diphenyl-1,3-..
  53. Stoepker C, Ameziane N, van der Lelij P, Kooi I, Oostra A, Rooimans M, et al. Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer. Cancer Res. 2015;75:3543-53 pubmed publisher
    ..for chromosomal breakage in one cell line, whereas in two other cell lines, somatic mutations in PDS5A or STAG2 resulted in inadequate sister chromatid cohesion...
  54. Ribera J, Zamora L, Morgades M, Mallo M, Solanes N, Batlle M, et al. Copy number profiling of adult relapsed B-cell precursor acute lymphoblastic leukemia reveals potential leukemia progression mechanisms. Genes Chromosomes Cancer. 2017;56:810-820 pubmed publisher cell proliferation, drug resistance and stem cell homeostasis regulation, as well as deletions of KDM6A and STAG2 genes emerged as specific alterations at relapse...
  55. Kojic A, Cuadrado A, De Koninck M, Giménez Llorente D, Rodríguez Corsino M, Gomez Lopez G, et al. Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization. Nat Struct Mol Biol. 2018;25:496-504 pubmed publisher
    ..variant cohesin complexes containing SMC1, SMC3, RAD21 and either SA1 (also known as STAG1) or SA2 (also known as STAG2) are present in all cell types...
  56. Lin D, Mayakonda A, Dinh H, Huang P, Lin L, Liu X, et al. Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma. Cancer Res. 2017;77:2255-2265 pubmed publisher
    ..carcinoma cases, with 29% of driver mutations being heterogeneous, including TERT, ARID1A, NOTCH2, and STAG2. Similar with other cancer types, TP53 mutations were always shared between all tumor regions, that is, located on ..
  57. Kong X, Ball A, Yokomori K. The Use of Laser Microirradiation to Investigate the Roles of Cohesins in DNA Repair. Methods Mol Biol. 2017;1515:227-242 pubmed
    ..revealing the damage site-specific functions of cohesin and, more recently, uncovering the unique role of cohesin-SA2, one of the two cohesin complexes uniquely present in higher eukaryotes, in DNA repair in human cells...
  58. Doi H, Tokura Y, Mori Y, Mori K, Asakura Y, Usuda Y, et al. Identification of enzymes responsible for extracellular alginate depolymerization and alginate metabolism in Vibrio algivorus. Appl Microbiol Biotechnol. 2017;101:1581-1592 pubmed publisher
    ..Recently, Vibrio algivorus sp. SA2T was identified as a novel alginate-decomposing and alginate-utilizing species...
  59. Thol F, Bollin R, Gehlhaar M, Walter C, Dugas M, Suchanek K, et al. Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications. Blood. 2014;123:914-20 pubmed publisher
    ..In this study, we analyzed the frequency, clinical, and prognostic implications of mutations in STAG1, STAG2, SMC1A, SMC3, and RAD21, all members of the cohesin complex, in a cohort of 389 uniformly treated AML patients by ..
  60. Niu H, Song D, Sun Y, Zhang W, Mu H, Duan J. Preparation and sulfation of an ?-glucan from Actinidia chinensis roots and their potential activities. Int J Biol Macromol. 2016;92:981-987 pubmed publisher
    ..Three sulfated derivatives of ACPA1 (SA1, SA2 and SA3) with different degrees of sulfation (DS) were obtained by SO3-pyridine procedure...
  61. Mahbub K, Krishnan K, Andrews S, Venter H, Naidu R, Megharaj M. Bio-augmentation and nutrient amendment decrease concentration of mercury in contaminated soil. Sci Total Environ. 2017;576:303-309 pubmed publisher
    ..1, 2.2, 4 and 0.9%) were subjected to bioremediation utilizing a Hg volatilizing bacterial strain Sphingobium SA2 and nutrient amendment...
  62. Di Benedetto D, Musumeci S, Avola E, Alberti A, Buono S, Scuderi C, et al. Definition of minimal duplicated region encompassing the XIAP and STAG2 genes in the Xq25 microduplication syndrome. Am J Med Genet A. 2014;164A:1923-30 pubmed publisher
    ..Recently, small duplications involving this genomic region and encompassing the GRIA3 and STAG2 genes have been reported...
  63. De Conti L, Akinyi M, Mendoza Maldonado R, Romano M, Baralle M, Buratti E. TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways. Nucleic Acids Res. 2015;43:8990-9005 pubmed publisher
    ..alters the levels of isoform expression in four genes potentially important for neuropathology: MADD/IG20, STAG2, FNIP1 and BRD8. For MADD/IG20 and STAG2, these changes could also be confirmed at the protein level...
  64. Shiba N, Yoshida K, Shiraishi Y, Okuno Y, Yamato G, Hara Y, et al. Whole-exome sequencing reveals the spectrum of gene mutations and the clonal evolution patterns in paediatric acute myeloid leukaemia. Br J Haematol. 2016;175:476-489 pubmed publisher
    ..paediatric AML patients identified three major categories of recurrently mutated genes: cohesion complex genes [STAG2, RAD21 and SMC3 in 17 patients (8·3%)], epigenetic regulators [ASXL1/ASXL2 in 17 patients (8·3%), BCOR/BCORL1 in ..
  65. Wu C, Friedlander P, Lamoureux C, Zannis Hadjopoulos M, Price G. cDNA clones contain autonomous replication activity. Biochim Biophys Acta. 1993;1174:241-57 pubmed
    ..Two NOA clones (NOA4 and -5) did not contain any representations of ARS and SAR consensus sequences, suggesting that these two features may not be essential for autonomous replication activity in mammalian cells. ..
  66. Mahbub K, Krishnan K, Megharaj M, Naidu R. Bioremediation potential of a highly mercury resistant bacterial strain Sphingobium SA2 isolated from contaminated soil. Chemosphere. 2016;144:330-7 pubmed publisher
    A mercury resistant bacterial strain, SA2, was isolated from soil contaminated with mercury...
  67. Patel J, Schumacher J, Frizzell K, Sorrells S, Shen W, Clayton A, et al. Coexisting and cooperating mutations in NPM1-mutated acute myeloid leukemia. Leuk Res. 2017;56:7-12 pubmed publisher
    ..DNMT3A, TET2, IDH1, IDH2), RNA splicing (SRSF2, SF3B1), or in the cohesin complex (RAD21, SMC1A, SMC3, STAG2)...
  68. Fajemiroye J, Prabhakar P, Cunha L, Costa E, Zjawiony J. 22-azidosalvinorin A exhibits antidepressant-like effect in mice. Eur J Pharmacol. 2017;800:96-106 pubmed publisher
    ..of its four derivatives; 22-methylsulfanylsalvinorin A(SA1), 2-O-cinnamoylsalvinorin B (CSB), 22-azidosalvinorin A (SA2), and 2-O-(4'-azidophenylsulfonyl)salvinorin B (SA3)...
  69. Aquila L, Ohm J, Woloszynska Read A. The role of STAG2 in bladder cancer. Pharmacol Res. 2018;131:143-149 pubmed publisher
    Stromal Antigen 2 (STAG2) is one of four components of the cohesin complex and predominantly functions in sister chromatid cohesion and segregation...
  70. Cheung H, Yang Y, Lee T, RENNERT O, Chan W. Hypermethylation of genes in testicular embryonal carcinomas. Br J Cancer. 2016;114:230-6 pubmed publisher
    ..Among the confirmed genes, five were sex-linked genes, including X-linked genes STAG2, SPANXD/E and MIR1184, and Y-linked genes RBMY1A1/1B/1D and FAM197Y2P...
  71. Gaidzik V, Teleanu V, Papaemmanuil E, Weber D, Paschka P, Hahn J, et al. RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features. Leukemia. 2016;30:2160-2168 pubmed publisher epigenetic modifiers (ASXL1, IDH2, KMT2A, EZH2), components of the spliceosome complex (SRSF2, SF3B1) and STAG2, PHF6, BCOR. RUNX1 mutations were associated with older age (16-59 years: 8.5%; ?60 years: 15...
  72. Xu D, Guo Y, Liu T, Li S, Sun Y. miR-22 contributes to endosulfan-induced endothelial dysfunction by targeting SRF in HUVECs. Toxicol Lett. 2017;269:33-40 pubmed publisher
    ..Luciferase reporter assay confirmed that SRF and STAG2 were novel direct targets of miR-22...
  73. Djos A, Fransson S, Kogner P, Martinsson T. Aneuploidy in neuroblastoma tumors is not associated with inactivating point mutations in the STAG2 gene. BMC Med Genet. 2013;14:102 pubmed publisher
    ..b>STAG2 encodes a subunit of the cohesion complex that participates in mitotic chromatid separation and was recently found ..
  74. Brohl A, Solomon D, Chang W, Wang J, Song Y, Sindiri S, et al. The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation. PLoS Genet. 2014;10:e1004475 pubmed publisher
    ..15 mutations/Mb) but frequent deleterious mutations in the cohesin complex subunit STAG2 (21.5% tumors, 44.4% cell lines), homozygous deletion of CDKN2A (13.8% and 50%) and mutations of TP53 (6.2% and 71...
  75. Ganguly B, Kadam N. Mutations of myelodysplastic syndromes (MDS): An update. Mutat Res Rev Mutat Res. 2016;769:47-62 pubmed publisher
    ..RUNX1); signal transduction/kinases (FLT3, JAK2); RAS pathway (KRAS, NRAS, CBL, NF1, PTPN11); cohesin complex (STAG2, CTCF, SMC1A, RAD21); DNA repair (ATM, BRCC3, DLRE1C, FANCL); and other pathway genes have given insights into the ..
  76. Daniloski Z, Smith S. Loss of Tumor Suppressor STAG2 Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells. Cancer Res. 2017;77:5530-5542 pubmed publisher
    ..The STAG2 gene encoding SA2 is often inactivated in human cancer, but not in in a manner associated with aneuploidy...
  77. Lee J, Seo H, Im K, Park S, Kim S, Lee E, et al. Idiopathic hypereosinophilia is clonal disorder? Clonality identified by targeted sequencing. PLoS ONE. 2017;12:e0185602 pubmed publisher
    ..3%) harbored at least one candidate mutation. The most frequently affected genes were NOTCH1 (26.7%), SCRIB and STAG2 (16.7%), and SH2B3 (13.3%)...
  78. Al Affan I, Evans S, Qutub M, Hugtenburg R. A novel technique to optimise the length of a linear accelerator treatment room maze without compromising radiation protection. J Radiol Prot. 2017;: pubmed publisher
    ..I A M Al-Affan†, S C Evans‡, M Qutub†,1 and R P Hugtenburg†,‡
 †Swansea University, Swansea SA2 8PP, UK
 ‡Department of Medical Physics and Clinical Engineering, Singleton Hospital, Swansea, SA2 8QA, ..
  79. Singh A, Raj V, Keshari A, Rai A, Kumar P, Rawat A, et al. Isolated mangiferin and naringenin exert antidiabetic effect via PPAR?/GLUT4 dual agonistic action with strong metabolic regulation. Chem Biol Interact. 2018;280:33-44 pubmed publisher
    In this study, we isolated two compounds from the leaves of Salacia oblonga (SA1, mangiferin and SA2, naringenin), and their structures were confirmed by infrared spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and mass ..
  80. Gregson H, Schmiesing J, Kim J, Kobayashi T, Zhou S, Yokomori K. A potential role for human cohesin in mitotic spindle aster assembly. J Biol Chem. 2001;276:47575-82 pubmed
    ..Our results raise the intriguing possibility that in addition to its well demonstrated function in sister chromatid cohesion, cohesin may be involved in spindle assembly during mitosis. ..
  81. Chung N, Kim M, Yoo N, Lee S. Somatic mutation of STAG2, an aneuploidy-related gene, is rare in acute leukemias. Leuk Lymphoma. 2012;53:1234-5 pubmed publisher
  82. Taylor C, Platt F, Hurst C, Thygesen H, Knowles M. Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes. Hum Mol Genet. 2014;23:1964-74 pubmed publisher
    Inactivating mutations of STAG2 have been reported at low frequency in several cancers. In glioblastoma, the function of STAG2 has been related to maintenance of euploidy via its role in the cohesin complex...
  83. Mullegama S, Klein S, Mulatinho M, Senaratne T, Singh K, Nguyen D, et al. De novo loss-of-function variants in STAG2 are associated with developmental delay, microcephaly, and congenital anomalies. Am J Med Genet A. 2017;173:1319-1327 pubmed publisher
    ..205C>T; p.(Arg69*)) in the integral cohesin structural protein, STAG2. This variant is associated with decreased STAG2 protein expression...
  84. Benedetti L, Cereda M, Monteverde L, Desai N, Ciccarelli F. Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1. Oncotarget. 2017;8:37619-37632 pubmed publisher
    ..Here we show that the loss-of-function of STAG2, a core component of cohesin and an emerging tumour suppressor, leads to synthetic dependency of mutated cancer ..
  85. Strachan T. Cornelia de Lange Syndrome and the link between chromosomal function, DNA repair and developmental gene regulation. Curr Opin Genet Dev. 2005;15:258-64 pubmed
  86. Gomes C, Bernardes V, Odell E, Gomez R. STAG2 loss of expression is rare in aneuploid malignant salivary gland neoplasms. J Oral Pathol Med. 2014;43:273-5 pubmed
    b>STAG2 depletion leads to loss of centromere cohesion in vitro, and some human neoplasms have been shown to lose expression of this protein...
  87. Leroy C, Jacquemont M, Doray B, Lamblin D, Cormier Daire V, Philippe A, et al. Xq25 duplication: the crucial role of the STAG2 gene in this novel human cohesinopathy. Clin Genet. 2016;89:68-73 pubmed publisher
    ..interval allowed further refinement of the shortest region of overlap to 173 kb, including only one gene, STAG2, which encodes a component of the cohesin complex...
  88. Li X, Zhang T, Tang J, Fa P, Lu J, Qi F, et al. Loss of STAG2 causes aneuploidy in normal human bladder cells. Genet Mol Res. 2015;14:2638-46 pubmed publisher
    The aim of this study was to determine how the function of human stromal antigen 2 (STAG2) plays an important role in proper chromosome separation. STAG2 mRNA in normal bladder cells and bladder tumor cells was evaluated by RT-PCR...
  89. França J, Diniz M, Bernardes V, Costa Silva R, Souza R, Gomez R, et al. Cohesin subunits, STAG1 and STAG2, and cohesin regulatory factor, PDS5b, in oral squamous cells carcinomas. J Oral Pathol Med. 2017;46:188-193 pubmed publisher
    Cohesin complex is responsible for sister chromatid cohesion. STAG1/STAG2 is part of the complex, which is regulated by PDS5B. Alterations in these genes were described in tumors. PDS5B is a negative regulator of cell proliferation...
  90. Tirado Torres D, Acevedo Sandoval O, Rodríguez Pastrana B, Gayosso Canales M. Phylogeny and polycyclic aromatic hydrocarbons degradation potential of bacteria isolated from crude oil-contaminated site. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2017;52:897-904 pubmed publisher
    ..The identified bacteria were Ochrobactrum intermedium, Pandoraea pnomenusa and Ochrobactrum sp., but SA2-09 strain was not identified...
  91. Deardorff M, Bando M, Nakato R, Watrin E, Itoh T, Minamino M, et al. HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. Nature. 2012;489:313-7 pubmed publisher
  92. Bailey M, O Neil N, van Pel D, Solomon D, Waldman T, Hieter P. Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition. Mol Cancer Ther. 2014;13:724-32 pubmed publisher
    Recent data have identified STAG2, a core subunit of the multifunctional cohesin complex, as a highly recurrently mutated gene in several types of cancer...