Gene Symbol: ST6GALNAC2
Description: ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Alias: SAITL1, SIAT7, SIAT7B, SIATL1, ST6GalNAII, STHM, alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2, (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide B, (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase, SIAT7-B, ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2, ST6 GalNAc alpha-2,6-sialyltransferase 2, ST6GALNAC2, alpha-2,6-sialyltransferase 2, ST6GalNAc II, ST6GalNAcII, galNAc alpha-2,6-sialyltransferase II, sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide B, sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) B, sialyltransferase 7B, sialyltransferase-like 1
Species: human
Products:     ST6GALNAC2

Top Publications

  1. Raska M, Moldoveanu Z, Suzuki H, Brown R, Kulhavy R, Andrasi J, et al. Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells. J Mol Biol. 2007;369:69-78 pubmed
    ..These data are the first evidence that human cells that lack ST6-GalNAcI can sialylate core 1 GalNAc-Ser/Thr. ..
  2. Wang C, Ye M, Zhao Q, Xia M, Liu D, He L, et al. Loss of the Golgi Matrix Protein 130 Cause Aberrant IgA1 Glycosylation in IgA Nephropathy. Am J Nephrol. 2019;49:307-316 pubmed publisher
    ..Real-time PCR and Western blot were used to analyze the levels of β1,3-Gal transferase (C1GALT1) and ST6GalNAC2, respectively...
  3. Janus P, Sierakowski A, Rudek M, Kunicki P, Dzierka A, Biczysko P, et al. Thermal nanometrology using piezoresistive SThM probes with metallic tips. Ultramicroscopy. 2018;193:104-110 pubmed publisher
    In this paper we present design and application of novel piezoresistive scanning thermal microscopy (SThM) probes. The proposed probe integrates a piezoresistive deflection sensor and thermally active, resistive nanosize tip...
  4. Xu K, Ye S, Lei L, Meng L, Hussain S, Zheng Z, et al. Dynamic interfacial mechanical-thermal characteristics of atomically thin two-dimensional crystals. Nanoscale. 2018;10:13548-13554 pubmed publisher
    ..Here, applying scanning thermal microscopy (SThM), we observed a novel mechanical-thermal coupling effect in monolayer/bilayer MoS2 and WS2 films: puckering ..
  5. Yazawa E, Geddes Sweeney J, Cedeno Laurent F, Walley K, Barthel S, Opperman M, et al. Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential. J Invest Dermatol. 2015;135:1849-1862 pubmed publisher
    ..melanoma cell Gal-1 ligand activity conferred by O-glycans was negatively regulated by α2,6 sialyltransferase ST6GalNAc2. In Gal-1-deficient mice, MCAM-silenced (MCAM(KD)) or ST6GalNAc2-overexpressing (ST6(O/E)) melanoma cells ..
  6. Xie Y, He L, Chen X, Peng X, Ye M, Zhao Y, et al. Potential diagnostic biomarkers for IgA nephropathy: a comparative study pre- and post-tonsillectomy. Int Urol Nephrol. 2016;48:1855-1861 pubmed
    The proteins BAFF, ST6GALNAC2, C1GALT1, and COSMC in peripheral blood mononuclear cells (PBMCs) and plasma levels of IgA1 and galactose-deficient IgA1 (Gd-IgA1) are potential biomarkers for IgAN nephropathy...
  7. Juszczyk J, Kaźmierczak Bałata A, Firek P, Bodzenta J. Measuring thermal conductivity of thin films by Scanning Thermal Microscopy combined with thermal spreading resistance analysis. Ultramicroscopy. 2017;175:81-86 pubmed publisher
    ..It bases on Scanning Thermal Microscopy (SThM) measurement combined with thermal spreading resistance analysis for a system consisting of a single layer on a ..
  8. Timofeeva M, Bolshakov A, Tovee P, Zeze D, Dubrovskii V, Kolosov O. Scanning thermal microscopy with heat conductive nanowire probes. Ultramicroscopy. 2016;162:42-51 pubmed publisher
    Scanning thermal microscopy (SThM), which enables measurement of thermal transport and temperature distribution in devices and materials with nanoscale resolution is rapidly becoming a key approach in resolving heat dissipation problems ..
  9. Chae H, Hwang G, Kwon O. Fabrication of scanning thermal microscope probe with ultra-thin oxide tip and demonstration of its enhanced performance. Ultramicroscopy. 2016;171:195-203 pubmed publisher
    ..Although several new advanced methods for scanning thermal microscopy (SThM) have been developed to meet these needs, such methods require a drastic enhancement of SThM probe performance...

More Information


  1. Xu Z, Ji C, Zhang Y, Zhang Z, Nie Q, Xu J, et al. Combination analysis of genome-wide association and transcriptome sequencing of residual feed intake in quality chickens. BMC Genomics. 2016;17:594 pubmed publisher
    ..e., MGP, HIST1H110, HIST1H2A4L3, OC3, NR0B2, PER2, ST6GALNAC2, and G0S2) were also identified as DEGs in chickens with divergent RFIs...
  2. Hwang G, Kwon O. Measuring the size dependence of thermal conductivity of suspended graphene disks using null-point scanning thermal microscopy. Nanoscale. 2016;8:5280-90 pubmed publisher
    Using null-point scanning thermal microscopy (NP SThM), we have measured and analyzed the size dependence of the thermal conductivity of graphene...
  3. Wielgoszewski G, Pałetko P, Tomaszewski D, Zaborowski M, Jóźwiak G, Kopiec D, et al. Carrier density distribution in silicon nanowires investigated by scanning thermal microscopy and Kelvin probe force microscopy. Micron. 2015;79:93-100 pubmed publisher
    The use of scanning thermal microscopy (SThM) and Kelvin probe force microscopy (KPFM) to investigate silicon nanowires (SiNWs) is presented...
  4. Lo C, Antonopoulos A, Gupta R, Qu J, Dell A, Haslam S, et al. Competition between core-2 GlcNAc-transferase and ST6GalNAc-transferase regulates the synthesis of the leukocyte selectin ligand on human P-selectin glycoprotein ligand-1. J Biol Chem. 2013;288:13974-87 pubmed publisher
    ..In particular, ST6GalNAc2 overexpression abrogated cell surface HECA-452/CLA expression, reduced the number of rolling leukocytes on P- ..
  5. Sachat A, Reparaz J, Spièce J, Alonso M, Goñi A, Garriga M, et al. Thermal transport in epitaxial Si1-x Ge x alloy nanowires with varying composition and morphology. Nanotechnology. 2017;28:505704 pubmed publisher
    ..The thermal properties were studied by means of scanning thermal microscopy (SThM), while the microstructural characteristics, the spatial distribution of the elemental composition of the alloy ..
  6. Miao X, Zhao Y. ST6GalNAcII mediates tumor invasion through PI3K/Akt/NF-κB signaling pathway in follicular thyroid carcinoma. Oncol Rep. 2016;35:2131-40 pubmed publisher
    ..The present study investigated the alteration in expression of ST6GalNAcII involved in invasion and to clarify the possible mechanism of ST6GalNAcII in the metastasis process in human ..
  7. Ding J, Xu L, Zhu L, Lv J, Zhao M, Zhang H, et al. Activity of alpha2,6-sialyltransferase and its gene expression in peripheral B lymphocytes in patients with IgA nephropathy. Scand J Immunol. 2009;69:174-80 pubmed publisher
    ..result from changes in the activity of alpha2,6-sialyltransferase (alpha2,6-ST) or expression of its coding gene ST6GALNAC2 in peripheral B lymphocytes. Sixty patients with IgAN and 20 healthy controls were enrolled...
  8. Moremen K, Ramiah A, Stuart M, Steel J, Meng L, Forouhar F, et al. Expression system for structural and functional studies of human glycosylation enzymes. Nat Chem Biol. 2018;14:156-162 pubmed publisher
    ..and characterized a subset of the enzymes, and determined the structure of one enzyme, the sialyltransferase ST6GalNAcII. Many enzymes were produced at high yields and at similar levels in both hosts, but individual protein ..
  9. Ge Y, Zhang Y, Weaver J, Dobson P. Dimension- and shape-dependent thermal transport in nano-patterned thin films investigated by scanning thermal microscopy. Nanotechnology. 2017;28:485706 pubmed publisher
    Scanning thermal microscopy (SThM) is a technique which is often used for the measurement of the thermal conductivity of materials at the nanometre scale...
  10. Ren D, Jia L, Li Y, Gong Y, Liu C, Zhang X, et al. ST6GalNAcII mediates the invasive properties of breast carcinoma through PI3K/Akt/NF-?B signaling pathway. IUBMB Life. 2014;66:300-8 pubmed publisher
    ..Real-time PCR, Western blot, and immunohistochemical were used to analyze differential expression of ST6GalNAc II in breast carcinoma cell lines and tissue specimens. PI3K/AKt signaling pathway was also analyzed...
  11. Suzuki H, Raska M, Yamada K, Moldoveanu Z, Julian B, Wyatt R, et al. Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes. J Biol Chem. 2014;289:5330-9 pubmed publisher
    ..These data provide a mechanism explaining increased immune-complex formation and disease exacerbation during mucosal infections in IgAN patients. ..
  12. Zhu L, Tang W, Li G, Lv J, Ding J, Yu L, et al. Interaction between variants of two glycosyltransferase genes in IgA nephropathy. Kidney Int. 2009;76:190-8 pubmed publisher
    ..We earlier found that haplotypes in two key glycosyltransferase genes, C1GALT1 and ST6GALNAC2, were associated with susceptibility to IgAN...
  13. Venkitachalam S, Revoredo L, Varadan V, Fecteau R, Ravi L, Lutterbaugh J, et al. Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer. Sci Rep. 2016;6:23642 pubmed publisher
    ..In particular, we observed an enrichment of mutations in genes (B3GNT2, B4GALT2, ST6GALNAC2) involved in the biosynthesis of N- and Cores 1-3 O-linked glycans in the colon, accounting for ~16% of the CRCs ..
  14. Ren D, Li Y, Gong Y, Xu J, Miao X, Li X, et al. Phyllodes tumor of the breast: role of Axl and ST6GalNAcII in the development of mammary phyllodes tumors. Tumour Biol. 2014;35:9603-12 pubmed publisher
    ..Axl and ST6GalNAcII expression increases with increasing tumor grade in mammary phyllodes tumors. ST6GalNAc II might be participated in the glycosylation of Axl, and this Axl glycosylation may mediate the tumorigenicity, ..
  15. Liu B, Liu Y, Zhao L, Pan Y, Shan Y, Li Y, et al. Upregulation of microRNA-135b and microRNA-182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway. Mol Carcinog. 2017;56:2669-2680 pubmed publisher
    ..The study was to explore whether miR-135b and miR-182 modulated 5-FU chemoresistance of CRC by targeting ST6GALNAC2 via PI3K/AKT pathway...
  16. Jia L, Luo S, Ren X, Li Y, Hu J, Liu B, et al. miR-182 and miR-135b Mediate the Tumorigenesis and Invasiveness of Colorectal Cancer Cells via Targeting ST6GALNAC2 and PI3K/AKT Pathway. Dig Dis Sci. 2017;62:3447-3459 pubmed publisher
    ..the association of miR-182 and miR-135b with proliferation and invasion by targeting sialyltransferase ST6GALNAC2 in CRC cells and explore the potential molecular mechanism...
  17. Li G, Zhu L, Zhang H, LV J, Ding J, Zhao M, et al. Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy. Hum Mutat. 2007;28:950-7 pubmed
    ..In the present study, we designed an association study to investigate polymorphisms of two important genes, ST6GALNAC2 and NEU1, which are involved in the sialylation of the IgA1 molecule, in the susceptibility to IgAN...
  18. Samyn Petit B, Krzewinski Recchi M, Steelant W, Delannoy P, Harduin Lepers A. Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells. Biochim Biophys Acta. 2000;1474:201-11 pubmed
    ..This sialyltransferase sequence is similar to that of previously cloned ST6GalNAc II (chicken and mouse) and shows the sialylmotifs that are present in all eukaryotic members of the ..
  19. Yamagata H, Uchida S, Matsuo K, Harada K, Kobayashi A, Nakashima M, et al. Altered plasma protein glycosylation in a mouse model of depression and in patients with major depression. J Affect Disord. 2018;233:79-85 pubmed publisher
    ..Moreover, the expression of ST6GALNAC2 was decreased in leukocytes from patients with MDD...
  20. Yalon E, Deshmukh S, Muñoz Rojo M, Lian F, Neumann C, Xiong F, et al. Spatially Resolved Thermometry of Resistive Memory Devices. Sci Rep. 2017;7:15360 pubmed publisher
    ..Here we show that the combination of Raman thermometry and scanning thermal microscopy (SThM) can enable such measurements with high spatial resolution...
  21. Murugaesu N, Iravani M, van Weverwijk A, Ivetic A, Johnson D, Antonopoulos A, et al. An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor. Cancer Discov. 2014;4:304-17 pubmed publisher
    ..Using this approach, we identified the sialyltransferase ST6GalNAc2 as a novel breast cancer metastasis suppressor...