Gene Symbol: ST6GALNAC1
Description: ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Alias: HSY11339, SIAT7A, ST6GalNAcI, STYI, alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, GalNAc alpha-2, 6-sialyltransferase I, long form, SIAT7-A, ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1, ST6 GalNAc alpha-2,6-sialyltransferase 1, ST6GALNAC1, alpha-2,6-sialyltransferase 1, ST6GalNAc I, galNAc alpha-2,6-sialyltransferase I, sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) A, sialyltransferase 7A
Species: human
Products:     ST6GALNAC1

Top Publications

  1. Ikehara Y, Kojima N, Kurosawa N, Kudo T, Kono M, Nishihara S, et al. Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens. Glycobiology. 1999;9:1213-24 pubmed
    ..The long form cDNA was considered to encode a human homologue of chick ST6GalNAc I for the following reasons: (1) the putative amino acid sequence showed greater homology to that of chick ..
  2. Julien S, Krzewinski Recchi M, Harduin Lepers A, Gouyer V, Huet G, Le Bourhis X, et al. Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA. Glycoconj J. 2001;18:883-93 pubmed
    ..This reaction is mainly catalyzed by a CMP-Neu5Ac GalNAc alpha2,6-sialyltransferase: ST6GalNAc I. In order to generate STn-positive breast cancer cells, we have cloned a cDNA encoding the full-length human ..
  3. Gao L, He R, Wu H, Zhang T, Liang H, Ye Z, et al. Expression Signature and Role of miR-30d-5p in Non-Small Cell Lung Cancer: a Comprehensive Study Based on in Silico Analysis of Public Databases and in Vitro Experiments. Cell Physiol Biochem. 2018;50:1964-1987 pubmed publisher
    ..Among the 12 identified hub genes, nine genes including E2F3, CCNE2, SKP2, CDK6, TFDP1, LDHA, GOT2, DNMT3B and ST6GALNAC1 were validated by Pearson's correlation test and the human protein atlas (HPA) database as targets of miR-30d-5p ..
  4. Oliveira E, Santana F, Oliveira L, Santos V. Genetic parameters and prediction of genotypic values for root quality traits in cassava using REML/BLUP. Genet Mol Res. 2014;13:6683-700 pubmed publisher
    ..traits included amylose content (AML), root dry matter (DMC), cyanogenic compounds (CyC), and starch yield (StYi). Estimates of the individual broad-sense heritability of AML were low (hg(2) = 0.07 ± 0...
  5. Munkley J, Vodák D, Livermore K, James K, Wilson B, Knight B, et al. Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability. EBioMedicine. 2016;8:103-116 pubmed publisher
    ..Of 31 reciprocally-regulated glycosylation enzymes, a set of 8 (GALNT7, ST6GalNAc1, GCNT1, UAP1, PGM3, CSGALNACT1, ST6GAL1 and EDEM3) were significantly up-regulated in clinical prostate ..
  6. Bak S, Staunstrup N, Starnawska A, Daugaard T, Nyengaard J, Nyegaard M, et al. Evaluating the Feasibility of DNA Methylation Analyses Using Long-Term Archived Brain Formalin-Fixed Paraffin-Embedded Samples. Mol Neurobiol. 2018;55:668-681 pubmed publisher from methylated DNA immunoprecipitation, clonal bisulfite sequencing, and pyrosequencing of BDNF and ST6GALNAC1 suggested that the original methylation pattern is indeed preserved...
  7. Munkley J. Glycosylation is a global target for androgen control in prostate cancer cells. Endocr Relat Cancer. 2017;24:R49-R64 pubmed publisher
    ..for androgen control in prostate cancer cells and further defined a set of 8 glycosylation enzymes (GALNT7, ST6GalNAc1, GCNT1, UAP1, PGM3, CSGALNACT1, ST6GAL1 and EDEM3), which are also significantly upregulated in prostate cancer ..
  8. Munkley J, Oltean S, Vodák D, Wilson B, Livermore K, Zhou Y, et al. The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer. Oncotarget. 2015;6:34358-74 pubmed publisher
    ..analyses of androgen-receptor (AR) binding sites and clinical PCa expression array data to identify ST6GalNAc1 as a direct and rapidly activated target gene of the AR in PCa cells...
  9. Rendón J, Cortés Mancera F, Duque Jaramillo A, Ospina M, Navas M. Analysis of hepatitis B virus genotypes by restriction fragment length polymorphism. Biomedica. 2015;36:79-88 pubmed publisher
    ..We analyzed PCR products by RFLP with AlwI, BsrI, CfrI, HpaII and StyI, and we sequenced some. We compared the patterns obtained with those in previous reports...

More Information


  1. Takamochi K, Ohmiya H, Itoh M, Mogushi K, Saito T, Hara K, et al. Novel biomarkers that assist in accurate discrimination of squamous cell carcinoma from adenocarcinoma of the lung. BMC Cancer. 2016;16:760 pubmed
    ..We identified two novel marker candidates, SPATS2 for SCC and ST6GALNAC1 for AD, as showing comparable performance and complementary utility to the known markers in discriminating PDSCC ..
  2. Munkley J. The Role of Sialyl-Tn in Cancer. Int J Mol Sci. 2016;17:275 pubmed publisher
    ..The biosynthesis of the sTn antigen has been linked to the expression of the sialytransferase ST6GalNAc1, and also to mutations in and loss of heterozygosity of the COSMC gene...
  3. Haldar D, Agrawal N, Patel S, Kambale P, Arora K, Sharma A, et al. Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study. Eur J Nutr. 2018;57:703-711 pubmed publisher
    ..Genotyping of VDBP single nucleotide polymorphisms (SNPs) rs7041 (HaeIII; G>T) and rs4588 (StyI; A>C) and CYP2R1 SNP rs2060793 (HinfI; A>G) was carried out by restriction fragment length polymorphism in 50 ..
  4. Munkley J, Livermore K, Rajan P, Elliott D. RNA splicing and splicing regulator changes in prostate cancer pathology. Hum Genet. 2017;136:1143-1154 pubmed publisher
    ..genes generate alternatively spliced mRNA isoforms, including a prostate-specific splice isoform of ST6GALNAC1 mRNA...
  5. Ozaki H, Matsuzaki H, Ando H, Kaji H, Nakanishi H, Ikehara Y, et al. Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model. Clin Exp Metastasis. 2012;29:229-38 pubmed publisher
    b>ST6GalNAcI is a sialyltransferase responsible for the synthesis of sialyl Tn (sTn) antigen which is expressed in a variety of adenocarcinomas including gastric cancer especially in advanced cases, but the roles of ST6GalNAcI and sTn in ..
  6. Hassinen A, Rivinoja A, Kauppila A, Kellokumpu S. Golgi N-glycosyltransferases form both homo- and heterodimeric enzyme complexes in live cells. J Biol Chem. 2010;285:17771-7 pubmed publisher
    ..Given their strict Golgi localization and sequential order of function, the two heterodimeric complexes are probably responsible for the processing and maturation of N-glycans in live cells. ..
  7. Patani N, Jiang W, Mokbel K. Prognostic utility of glycosyltransferase expression in breast cancer. Cancer Genomics Proteomics. 2008;5:333-40 pubmed
    ..Expression of ppGalNAc-T6 is significantly higher in breast cancer compared to 'normal'/benign breast tissue samples. ST6GalNAc-I expression in breast cancer is associated with better prognosis. ..
  8. Chik J, Zhou J, Moh E, Christopherson R, Clarke S, Molloy M, et al. Comprehensive glycomics comparison between colon cancer cell cultures and tumours: implications for biomarker studies. J Proteomics. 2014;108:146-62 pubmed publisher
    ..Using qRT-PCR, sialyl-Tn expression was found to be associated with an increase in ?2,6-sialyltransferase gene (ST6GALNAC1) and a decrease in core 1 synthase gene (C1GALT1) in LS174T cells...
  9. Lee Y, Kaufmann M, Kitazume Kawaguchi S, Kono M, Takashima S, Kurosawa N, et al. Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV. J Biol Chem. 1999;274:11958-67 pubmed
    ..Although the substrate specificity of this enzyme is similar to that of ST6GalNAc III, ST6GalNAc IV prefers O-glycans to glycolipids. Glycolipids, however, are better substrates for ST6GalNAc III. ..
  10. Tamura F, Sato Y, Hirakawa M, Yoshida M, Ono M, Osuga T, et al. RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells. Gastric Cancer. 2016;19:85-97 pubmed publisher
    b>ST6GalNAc I is a sialyltransferase controlling the expression of sialyl-Tn antigen (STn), which is overexpressed in several epithelial cancers, including gastric cancer, and is highly correlated with cancer metastasis...
  11. Sewell R, Bäckström M, Dalziel M, Gschmeissner S, Karlsson H, Noll T, et al. The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer. J Biol Chem. 2006;281:3586-94 pubmed
    ..3 to 3.8 per tandem repeat. The availability of large quantities of this MUC1 glycoform will allow the evaluation of its efficacy as an immunogen for immunotherapy of MUC1/STn-expressing tumors. ..
  12. Iwaya T, Sawada G, Amano S, Kume K, Ito C, Endo F, et al. Downregulation of ST6GALNAC1 is associated with esophageal squamous cell carcinoma development. Int J Oncol. 2017;50:441-447 pubmed publisher
    ..A significant downregulation of ST6GALNAC1 was demonstrated in ESCC tissues compared to its expression in normal tissues by qRT-PCR (n=93, p<0.0001)...
  13. Donadio S, Dubois C, Fichant G, Roybon L, Guillemot J, Breton C, et al. Recognition of cell surface acceptors by two human alpha-2,6-sialyltransferases produced in CHO cells. Biochimie. 2003;85:311-21 pubmed
    ..It is thus concluded that downstream from the transmembrane domain, native STs possess peptide sequences that allow them to sialylate glycoprotein acceptors selectively along their transit within Golgi stacks. ..
  14. Knuuttila M, Mehmood A, Huhtaniemi R, Yatkin E, Häkkinen M, Oksala R, et al. Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts. Am J Pathol. 2018;188:216-228 pubmed publisher
    ..However, other genes recently identified to be highly sensitive to androgen-regulated AR action, such as NOV and ST6GalNAc1, were markedly altered, which indicated reduced androgen action...
  15. Zhang D, Zhu L, Li C, Mu J, Fu Y, Zhu Q, et al. Sialyltransferase7A, a Klf4-responsive gene, promotes cardiomyocyte apoptosis during myocardial infarction. Basic Res Cardiol. 2015;110:28 pubmed publisher
    ..In this study, we found that sialyltransferase7A (Siat7A), one of the members of sialyltransferase family, was significantly increased in the ischemic myocardium, as well ..
  16. Więsyk A, Candresse T, Zagórski Ostoja W, Góra Sochacka A. Viability and genetic stability of potato spindle tuber viroid mutants with indels in specific loops of the rod-like secondary structure. Virus Res. 2017;240:94-100 pubmed publisher
    ..we have created 6 mutants carrying 3-4 nucleotides deletions or insertions at three unique restriction sites, EagI, StyI and AvaII...