Gene Symbol: ST3GAL1
Description: ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Alias: Gal-NAc6S, SIAT4A, SIATFL, ST3GalA, ST3GalA.1, ST3GalIA, ST3GalIA,1, ST3O, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1, Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase, SIAT4-A, ST3GalI, alpha 2,3-ST 1, beta-galactoside alpha-2,3-sialyltransferase 1, sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase), sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase), sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase)
Species: human
Products:     ST3GAL1

Top Publications

  1. Kitagawa H, Paulson J. Differential expression of five sialyltransferase genes in human tissues. J Biol Chem. 1994;269:17872-8 pubmed
    ..Comparison with fragmentary earlier studies of the expression of several of the same enzymes in rat tissues suggests that the overall pattern of expression is largely conserved. ..
  2. Vallejo Ruiz V, Haque R, Mir A, Schwientek T, Mandel U, Cacan R, et al. Delineation of the minimal catalytic domain of human Galbeta1-3GalNAc alpha2,3-sialyltransferase (hST3Gal I). Biochim Biophys Acta. 2001;1549:161-73 pubmed
  3. Picco G, Julien S, Brockhausen I, Beatson R, Antonopoulos A, Haslam S, et al. Over-expression of ST3Gal-I promotes mammary tumorigenesis. Glycobiology. 2010;20:1241-50 pubmed publisher
    ..This, we believe, is the first demonstration that over-expression of a glycosyltransferase involved in mucin-type O-linked glycosylation can promote tumorigenesis. ..
  4. Meng L, Forouhar F, Thieker D, Gao Z, Ramiah A, Moniz H, et al. Enzymatic basis for N-glycan sialylation: structure of rat α2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation. J Biol Chem. 2013;288:34680-98 pubmed publisher
    ..structure revealed an overall protein fold broadly resembling the previously determined structure of pig ST3GAL1, including a CMP-sialic acid-binding site assembled from conserved sialylmotif sequence elements...
  5. Sakuma K, Aoki M, Kannagi R. Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition. Proc Natl Acad Sci U S A. 2012;109:7776-81 pubmed publisher
    ..The transcript levels of the glycosyltransferase genes ST3GAL1/3/4 and FUT3 were significantly elevated and that of FUT2 was significantly suppressed by the treatment...
  6. Wu X, Zhao J, Ruan Y, Sun L, Xu C, Jiang H. Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-β1-induced EMT and confers paclitaxel resistance in ovarian cancer. Cell Death Dis. 2018;9:1102 pubmed publisher
    ..b>ST3GAL1 is a sialyltransferase that catalyzes the transfer of sialic acid from cytidine monophosphate-sialic acid to ..
  7. Lemopoulos A, Uusi Heikkilä S, Huusko A, Vasemägi A, Vainikka A. Comparison of Migratory and Resident Populations of Brown Trout Reveals Candidate Genes for Migration Tendency. Genome Biol Evol. 2018;10:1493-1503 pubmed publisher
    ..Two outlier SNPs mapped to genes involved in mucus secretion (ST3GAL1-like) and osmoregulation (C14orf37-like)...
  8. Fan T, Yeo H, Hsu H, Yu J, Ho M, Lin W, et al. Reciprocal feedback regulation of ST3GAL1 and GFRA1 signaling in breast cancer cells. Cancer Lett. 2018;434:184-195 pubmed publisher
    ..We found GFRA1 to be a substrate of ST3GAL1-mediated O-linked sialylation, which is crucial to GDNF-induced signaling in ER-positive breast cancer cells...
  9. Yuan Q, Chen X, Han Y, Lei T, Wu Q, Yu X, et al. Modification of α2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway. Int J Cancer. 2018;143:2319-2330 pubmed publisher
    ..In this study, we determined that mRNA levels of ST3GAL1, ST6GALNAC3 and ST8SIA6 were remarkably reduced in lung cancer tissues and cells, whereas ST6GAL1 level ..

More Information


  1. Agaram N, Sung Y, Zhang L, Chen C, Chen H, Singer S, et al. Dichotomy of Genetic Abnormalities in PEComas With Therapeutic Implications. Am J Surg Pathol. 2015;39:813-25 pubmed publisher
    ..Other nonrecurrent gene fusions, HTR4-ST3GAL1 and RASSF1-PDZRN3, were identified in 2 cases...
  2. Watson D, Wakarchuk W, Leclerc S, Schur M, Schoenhofen I, Young N, et al. Sialyltransferases with enhanced legionaminic acid transferase activity for the preparation of analogs of sialoglycoconjugates. Glycobiology. 2015;25:767-73 pubmed publisher
    ..Glycobiology. 21:99-108.]. These were the porcine ST3Gal1 and Pasteurella multocida sialyltransferases...
  3. Siiskonen S, Zhang M, Li W, Liang L, Kraft P, Nijsten T, et al. A Genome-Wide Association Study of Cutaneous Squamous Cell Carcinoma among European Descendants. Cancer Epidemiol Biomarkers Prev. 2016;25:714-20 pubmed publisher
    ..1 × 10(-6) in combined set; P = 1.4 × 10(-5) in the discovery and P = 0.02 in the replication), rs9643297 in ST3GAL1 gene (P = 8.2 × 10(-6) in combined set; P = 3.3 × 10(-5) in the discovery; and P = 0...
  4. Yu S, Zhao P, Sun T, Gao Z, Moremen K, Boons G, et al. Selective Exo-Enzymatic Labeling Detects Increased Cell Surface Sialoglycoprotein Expression upon Megakaryocytic Differentiation. J Biol Chem. 2016;291:3982-9 pubmed publisher
    ..and differentiated human erythroleukemia cells (HEL) using SEEL using the sialyltransferases ST6Gal1 and ST3Gal1, which label N- and O-glycans, respectively...
  5. Severino P, Silva M, Carrascal M, Malagolini N, Chiricolo M, Venturi G, et al. Oxidative damage and response to Bacillus Calmette-Guérin in bladder cancer cells expressing sialyltransferase ST3GAL1. BMC Cancer. 2018;18:198 pubmed publisher
    ..antigen, and its sialylated counterpart (Sia?2,3Gal?1,3GalNAc) sialyl-T (sT), synthesized by sialyltransferase ST3GAL1, whose roles in BCG response are unknown...
  6. Kidani S, Kaneoka H, Okuzaki Y, Asai S, Kojima Y, Nishijima K, et al. Analyses of chicken sialyltransferases related to O-glycosylation. J Biosci Bioeng. 2016;122:379-84 pubmed publisher
    The chicken ?-galactoside ?2,3-sialyltransferase 1, 2, and 5 (ST3Gal1, 2, and 5) genes were cloned, and their enzymes were expressed in 293FT cells...
  7. Jeong Y, Kang G, Kwon J, Choi H, Pack J, Kim N, et al. 1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer's Disease Mice. Curr Alzheimer Res. 2015;12:481-92 pubmed using hippocampus of WT and Tg- 5xFAD following RF-EMF exposure revealed that 5 genes (Tshz2, Gm12695, St3gal1, Isx and Tll1), which are involved in Aβ, are significantly altered inTg-5xFAD mice, exhibiting different ..
  8. Qin W, Gan L, Xia R, Dong W, Sun S, Zhu G, et al. Promoter identification and analysis of key glycosphingolipid biosynthesis-globo series pathway genes in piglets. Genet Mol Res. 2017;16: pubmed publisher
    Glycosphingolipid biosynthesis-globo series pathway genes (FUT1, FUT2, ST3GAL1, HEXA, HEXB, B3GALNT1, and NAGA) play an important regulatory role in the defense against Escherichia coli F18 in piglets...
  9. Inafuku S, Noda K, Amano M, Ohashi T, Yoshizawa C, Saito W, et al. Alteration of N-Glycan Profiles in Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2015;56:5316-22 pubmed publisher
    ..1 ± 21.2 pmol/100 μg protein, P < 0.0005). Expression levels of sialyltransferases ST3GAL1 and ST3GAL4 were upregulated in the HRMECs after high-glucose stimulation...
  10. Zhou H, Li Y, Liu B, Shan Y, Li Y, Zhao L, et al. Downregulation of miR-224 and let-7i contribute to cell survival and chemoresistance in chronic myeloid leukemia cells by regulating ST3GAL IV expression. Gene. 2017;626:106-118 pubmed publisher
    ..Thus we propose that miR-224 and let-7i regulate the proliferation and chemosensitivity of CML cells probably via targeting ST3GAL IV. ..
  11. Watson D, Wakarchuk W, Gervais C, Durocher Y, Robotham A, Fernandes S, et al. Preparation of legionaminic acid analogs of sialo-glycoconjugates by means of mammalian sialyltransferases. Glycoconj J. 2015;32:729-34 pubmed publisher
    ..interferon-α2b and α1-antitrypsin, by means of two mammalian sialyltransferases, namely porcine ST3Gal1 and human ST6Gal1...
  12. Czuchry D, Desormeaux P, Stuart M, Jarvis D, Matta K, Szarek W, et al. Identification and Biochemical Characterization of the Novel α2,3-Sialyltransferase WbwA from Pathogenic Escherichia coli Serotype O104. J Bacteriol. 2015;197:3760-8 pubmed publisher a common O-glycan structure in human glycoproteins and is synthesized by sialyltransferase ST3Gal1. The enterohemorrhagic Escherichia coli serotype O104 has the rare ability to synthesize a sialyl-T antigen mimic...
  13. Shang J, Qiu R, Wang J, Liu J, Zhou R, Ding H, et al. Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver. Eur J Biochem. 1999;265:580-8 pubmed the previously cloned sialyltransferases, a cDNA encoding Galbeta1, 3GalNAc alpha2,3-sialyltransferase (SIATFL) has been isolated from human fetal liver...
  14. Maestri A, Sortica V, Tovo Rodrigues L, Santos M, Barbagelata L, Moraes M, et al. Siaα2-3Galβ1- Receptor Genetic Variants Are Associated with Influenza A(H1N1)pdm09 Severity. PLoS ONE. 2015;10:e0139681 pubmed publisher
    ..In the present study, two genetic variants of the ST3GAL1 gene, which encodes the Siaα2-3Galβ1- receptor to which influenza A(H1N1)pdm09 virus binds for entry into ..
  15. Nelson D, Yoshida E, Paulson M, Hengen P, Ge D, Kanwar B, et al. Genome-wide association study to characterize serum bilirubin elevations in patients with HCV treated with GS-9256, an HCV NS3 serine protease inhibitor. Antivir Ther. 2014;19:679-86 pubmed publisher
    ..The current study cannot rule out a role for common variants of weak effect, or a more complex model, including multiple contributing factors, such as rare variants and as yet unidentified environmental influences. ..
  16. McGrath L, Cornelis M, Lee P, Robinson E, Duncan L, Barnett J, et al. Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2013;162B:779-88 pubmed publisher
    ..This study illustrates a phenotypic framework for examining genetic contributions to functional impairment across psychiatric disorders. ..
  17. Ozel A, Moroi S, Reed D, Nika M, Schmidt C, Akbari S, et al. Genome-wide association study and meta-analysis of intraocular pressure. Hum Genet. 2014;133:41-57 pubmed publisher
    ..These results confirm the involvement of common variants in multiple genomic regions in regulating IOP and/or glaucoma risk. ..
  18. Petrosyan A, Cheng P. Golgi fragmentation induced by heat shock or inhibition of heat shock proteins is mediated by non-muscle myosin IIA via its interaction with glycosyltransferases. Cell Stress Chaperones. 2014;19:241-54 pubmed publisher
    ..We conclude that NMIIA is the master regulator of Golgi fragmentation induced by heat shock or inhibition/depletion of HSP70/90. ..
  19. Sproviero D, Julien S, Burford B, Taylor Papadimitriou J, Burchell J. Cyclooxygenase-2 enzyme induces the expression of the ?-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer. J Biol Chem. 2012;287:44490-7 pubmed publisher
    ..Thus, these results suggest the intriguing possibility that some of the malignant characteristics associated with COX-2 expression may be via the influence that COX-2 exerts on the glycosylation of tumor cells. ..
  20. Schoenhofen I, Young N, Gilbert M. Biosynthesis of Legionaminic Acid and Its Incorporation Into Glycoconjugates. Methods Enzymol. 2017;597:187-207 pubmed publisher
    ..The two mammalian sialyltransferases that have been tested so far (porcine ST3Gal1 and human ST6Gal1) were found to be more efficient than the bacterial sialyltransferases for the modification of ..
  21. Videira P, Correia M, Malagolini N, Crespo H, Ligeiro D, Calais F, et al. ST3Gal.I sialyltransferase relevance in bladder cancer tissues and cell lines. BMC Cancer. 2009;9:357 pubmed publisher
    ..The overexpression of ST3Gal.I seems to be part of the initial oncogenic transformation of bladder and can be considered when predicting cancer progression and recurrence. ..
  22. Solatycka A, Owczarek T, Piller F, Piller V, Pula B, Wojciech L, et al. MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 ?1,6-N-acetylglucosaminyltransferase and ?-galactoside ?2,3-sialyltransferase. Glycobiology. 2012;22:1042-54 pubmed publisher
    ..We showed also that the overexpression of MUC1 in 4T1 cells changes their adhesive properties, as MUC1-expressing cells do not adhere to E-selectin, but bind galectin-3. ..
  23. Wen K, Sung P, Hsieh S, Chou Y, Lee O, Wu C, et al. α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells. Oncotarget. 2017;8:29013-29027 pubmed publisher
    ..We investigated the role of α2,3-sialyltransferase type I (ST3GalI) by analyzing human ovarian cancer datasets and human EOC tissue arrays...
  24. Noel M, Gilormini P, Cogez V, Yamakawa N, Vicogne D, Lion C, et al. Probing the CMP-Sialic Acid Donor Specificity of Two Human ?-d-Galactoside Sialyltransferases (ST3Gal?I and ST6Gal?I) Selectively Acting on O- and N-Glycosylproteins. Chembiochem. 2017;18:1251-1259 pubmed publisher
  25. Kiljański J, Ambroziak M, Pachucki J, Jazdzewski K, Wiechno W, Stachlewska E, et al. Thyroid sialyltransferase mRNA level and activity are increased in Graves' disease. Thyroid. 2005;15:645-52 pubmed
    ..These results indicate that sialyltransferases expression and activity are increased in GD. Exact mechanism of this upregulation remains unknown, though one of possible explanations is the activation of the thyrotropin (TSH) receptor. ..
  26. Li Y, Luo S, Dong W, Song X, Zhou H, Zhao L, et al. Alpha-2, 3-sialyltransferases regulate the multidrug resistance of chronic myeloid leukemia through miR-4701-5p targeting ST3GAL1. Lab Invest. 2016;96:731-40 pubmed publisher
    ..The altered expression level of ST3GAL1 was found corresponding to the drug-resistant phenotype (with and without adriamycin resistance) of CML cell ..
  27. Petrosyan A, Holzapfel M, Muirhead D, Cheng P. Restoration of compact Golgi morphology in advanced prostate cancer enhances susceptibility to galectin-1-induced apoptosis by modifying mucin O-glycan synthesis. Mol Cancer Res. 2014;12:1704-16 pubmed publisher associated with upregulation of sialyl-T antigen produced by ?-galactoside ?-2,3-sialyltransferase-1 (ST3Gal1) but not with core 2-associated polylactosamine despite expression of core 2 N-acetylglucosaminyltransferase-L (..
  28. Ferreira S, Vasconcelos J, Silva R, Cavalcanti C, Bezerra C, Rêgo M, et al. Expression patterns of ?2,3-sialyltransferase I and ?2,6-sialyltransferase I in human cutaneous epithelial lesions. Eur J Histochem. 2013;57:e7 pubmed publisher
  29. Chong Y, Sandanaraj E, Koh L, Thangaveloo M, Tan M, Koh G, et al. ST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis. J Natl Cancer Inst. 2016;108: pubmed publisher
    ..Glioblastoma is the most malignant primary brain tumor and is highly infiltrative. ST3GAL1 sialyltransferase gene is amplified in a subclass of glioblastomas, and its role in tumor cell self-renewal ..
  30. Kim H, Roh S, Sung Y, Chung H, Lee J, Cho J, et al. Genome-wide association study of the five-factor model of personality in young Korean women. J Hum Genet. 2013;58:667-74 pubmed publisher
    ..These findings contribute to our understanding of the genetic architecture of personality traits and provide critical clues to the neurobiological mechanisms that influence them. ..
  31. Jeanneau C, Chazalet V, Augé C, Soumpasis D, Harduin Lepers A, Delannoy P, et al. Structure-function analysis of the human sialyltransferase ST3Gal I: role of n-glycosylation and a novel conserved sialylmotif. J Biol Chem. 2004;279:13461-8 pubmed
    ..However, N-glycosylation appears to contribute to the proper folding and trafficking of the enzyme. ..
  32. Julien S, Grimshaw M, Sutton Smith M, Coleman J, Morris H, Dell A, et al. Sialyl-Lewis(x) on P-selectin glycoprotein ligand-1 is regulated during differentiation and maturation of dendritic cells: a mechanism involving the glycosyltransferases C2GnT1 and ST3Gal I. J Immunol. 2007;179:5701-10 pubmed
    ..Our data show that the regulation of O-glycosylation controls sLe(x) expression, and also suggest that O-glycans may have a function in DC migration. ..
  33. Chang M, Eddy R, Shows T, Lau J. Three genes that encode human beta-galactoside alpha 2,3-sialyltransferases. Structural analysis and chromosomal mapping studies. Glycobiology. 1995;5:319-25 pubmed
    ..3-qter of chromosome 11. The gene symbols for these genes have been designated SIAT4A, SIAT4B and SIAT4C, respectively...
  34. Van Dyken S, Green R, Marth J. Structural and mechanistic features of protein O glycosylation linked to CD8+ T-cell apoptosis. Mol Cell Biol. 2007;27:1096-111 pubmed
    ..We propose that an endogenous lectin activates an apoptotic pathway constructed in CD8+ T cells following TCR stimulation and enables contraction upon attenuation of immune signaling. ..
  35. Perlis R, Purcell S, Fagerness J, Kirby A, Petryshen T, Fan J, et al. Family-based association study of lithium-related and other candidate genes in bipolar disorder. Arch Gen Psychiatry. 2008;65:53-61 pubmed publisher
    ..Recent developments suggest that a broader pool of genes may be associated with this disorder...
  36. Zandi P, Zollner S, Avramopoulos D, Willour V, Chen Y, Qin Z, et al. Family-based SNP association study on 8q24 in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:612-8 pubmed publisher
    ..00 x 10(-4)) from both the single locus and multi-locus tests of associations with SNPs in the genes ADCY8, ST3GAL1, and NSE2. Multi-locus analyses suggested joint effects between ADCY8 and ST3GAL1 (P = 3...