Gene Symbol: SSTR1
Description: somatostatin receptor 1
Alias: SRIF-2, SS-1-R, SS1-R, SS1R, somatostatin receptor type 1
Species: human
Products:     SSTR1

Top Publications

  1. Papotti M, Bongiovanni M, Volante M, Allia E, Landolfi S, Helboe L, et al. Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis. Virchows Arch. 2002;440:461-75 pubmed
    ..It is concluded that SSTRs 1-5 are heterogeneously expressed in GEP endocrine tumors and that IHC is a reliable tool to detect SSTR types 2, 3 and 5 in surgical and biopsy specimens...
  2. Li M, Wang X, Li W, Li F, Yang H, Wang H, et al. Somatostatin receptor-1 induces cell cycle arrest and inhibits tumor growth in pancreatic cancer. Cancer Sci. 2008;99:2218-23 pubmed publisher
    ..This study suggests that gene therapy with SSTR-1 may be a potential adjuvant treatment for pancreatic cancer. ..
  3. Kharmate G, Rajput P, Watt H, Somvanshi R, Chaudhari N, Qiu X, et al. Role of somatostatin receptor 1 and 5 on epidermal growth factor receptor mediated signaling. Biochim Biophys Acta. 2011;1813:1172-89 pubmed publisher
    ..To gain further insight for the effect of SSTRs on EGFR activated signaling, we determine the role of SSTR1 and SSTR1/5 in human embryonic kidney (HEK) 293 cells...
  4. Zhao J, Liang Q, Cheung K, Kang W, Dong Y, Lung R, et al. Somatostatin receptor 1, a novel EBV-associated CpG hypermethylated gene, contributes to the pathogenesis of EBV-associated gastric cancer. Br J Cancer. 2013;108:2557-64 pubmed publisher
    Somatostatin receptor 1 (SSTR1) was preferentially methylated in Epstein-Barr virus (EBV)-positive gastric cancer using promoter methylation array...
  5. Gimpl G, Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol Rev. 2001;81:629-83 pubmed
    ..One has to conclude that the physiological regulation of the OT system will remain puzzling as long as the molecular mechanisms of genomic and nongenomic actions of steroids have not been clarified...
  6. Hua F, Shang S, Yang Y, Zhang H, Xu T, Yu J, et al. TRIB3 Interacts With β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis. Gastroenterology. 2019;156:708-721.e15 pubmed publisher
    ..Knockdown of TRIB3 decreases colon neoplasia in mice, migration of CRC cells, and their growth as xenograft tumors in mice. Strategies to block TRIB3 activity might be developed for treatment of CRC. ..
  7. Ubuka T, Tsutsui K. Evolution of gonadotropin-inhibitory hormone receptor and its ligand. Gen Comp Endocrinol. 2014;209:148-61 pubmed publisher
  8. Pérez Ibave D, Rodríguez Sánchez I, Garza Rodríguez M, Pérez Maya A, Luna M, Aramburo C, et al. Expression of growth hormone gene in the baboon eye. Exp Eye Res. 2018;169:157-169 pubmed publisher
    ..GHRH (growth hormone releasing hormone), GHRHR (growth hormone releasing hormone receptor), SST (somatostatin), SSTR1 (somatostatin receptor 1), SSTR2 (somatostatin receptor 2), SSTR3 (somatostatin receptor 3), SSTR4 (somatostatin ..
  9. Rayner B, Ramesar R. The importance of G protein-coupled receptor kinase 4 (GRK4) in pathogenesis of salt sensitivity, salt sensitive hypertension and response to antihypertensive treatment. Int J Mol Sci. 2015;16:5741-9 pubmed publisher
    ..It may also underlie the difference in hypertension between different geographically derived population groups, and form a basis for pharmacogenomic approaches to treatment of hypertension. ..

More Information

Publications161 found, 100 shown here

  1. Prud homme G, Glinka Y, Wang Q. Immunological GABAergic interactions and therapeutic applications in autoimmune diseases. Autoimmun Rev. 2015;14:1048-56 pubmed publisher
    ..However, the immune effects of GABAergic drugs in patients are not well documented. GABAergic immunobiology is a recent area of research, which shows potential for the development of new therapies for autoimmune diseases. ..
  2. Connor E, Evock Clover C, Walker M, Elsasser T, Kahl S. COMPARATIVE GUT PHYSIOLOGY SYMPOSIUM: Comparative physiology of glucagon-like peptide-2: Implications and applications for production and health of ruminants. J Anim Sci. 2015;93:492-501 pubmed publisher
    ..g., through specific feed additives), which are more likely to achieve consumer acceptance, are needed. Opportunities to address these challenges are discussed. ..
  3. Takenoya F, Wang L, Kageyama H, Hirako S, Wada N, Hashimoto H, et al. Neuropeptide W-Induced Hypophagia is Mediated Through Corticotropin-Releasing Hormone-Containing Neurons. J Mol Neurosci. 2015;56:789-98 pubmed publisher
    ..While NPW administration decreased feeding activity, the CRH antagonist inhibited this effect. These results strongly suggest that NPW regulates feeding behavior through CRH neurons in the mouse brain. ..
  4. Polhemus D, Gao J, Scarborough A, Trivedi R, McDonough K, Goodchild T, et al. Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling. Circ Res. 2016;119:470-80 pubmed publisher
    ..These findings provide new insights into the remote cardioprotective effects of RF-RDN acting directly on cardiac myocytes to attenuate cell death and protect against ischemic injury. ..
  5. Khan T, Ahmad R, Azad I, Raza S, Joshi S, Khan A. Computer-aided drug design and virtual screening of targeted combinatorial libraries of mixed-ligand transition metal complexes of 2-butanone thiosemicarbazone. Comput Biol Chem. 2018;75:178-195 pubmed publisher
  6. Wang S, Bao Z, Liang Q, Long J, Xiao Z, Jiang Z, et al. Octreotide stimulates somatostatin receptor-induced apoptosis of SW480 colon cancer cells by activation of glycogen synthase kinase-3?, A Wnt/?-catenin pathway modulator. Hepatogastroenterology. 2013;60:1639-46 pubmed
    ..Cell apoptosis of SW480 cells was measured by apoptosis-DNA ladder assay. SSTR1, SSTR2, SSTR3, SSTR4, and SSTR5 mRNA expression levels were confirmed by RT-PCR; ?-catenin, TCF-4, cyclin D1, c-..
  7. Ambrożewicz E, Wojcik P, Wroński A, Łuczaj W, Jastrząb A, Zarkovic N, et al. Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients. Cells. 2018;7: pubmed publisher
    ..In addition, increased expression of CB1 receptors leads to increased oxidative stress, lipid modifications, and inflammation, which, in turn, may promote the progression of psoriasis into the advanced, arthritic form of the disease. ..
  8. Kucharava K, Sekulic Jablanovic M, Horvath L, Bodmer D, Petkovic V. Pasireotide protects mammalian cochlear hair cells from gentamicin ototoxicity by activating the PI3K-Akt pathway. Cell Death Dis. 2019;10:110 pubmed publisher
    ..somatostatin and its selective analogs have provided neuroprotection by activating five somatostatin receptor (SSTR1-SSTR5) subtypes...
  9. Seemann S, Lupp A. Administration of AMD3100 in endotoxemia is associated with pro-inflammatory, pro-oxidative, and pro-apoptotic effects in vivo. J Biomed Sci. 2016;23:68 pubmed
  10. Sutton B, Palmer N, Langefeld C, Xue B, Proctor A, Ziegler J, et al. Association of SSTR2 polymorphisms and glucose homeostasis phenotypes: the Insulin Resistance Atherosclerosis Family Study. Diabetes. 2009;58:1457-62 pubmed publisher
    ..CONCLUSIONS We observed evidence for association of SSTR2 polymorphisms with measures of glucose homeostasis. Thus, variants in SSTR2 may influence pathways of S(I)to modulate glucose homeostasis. ..
  11. Koyama H, Iwakura H, Dote K, Bando M, Hosoda H, Ariyasu H, et al. Comprehensive Profiling of GPCR Expression in Ghrelin-Producing Cells. Endocrinology. 2016;157:692-704 pubmed publisher
    ..These results will lead to a greater understanding of the physiology of ghrelin and facilitate the development of ghrelin-modulating drugs. ..
  12. Raffetto J, Qiao X, Beauregard K, Khalil R. Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins. J Vasc Surg. 2010;51:972-81 pubmed publisher
    ..The decreased venous contraction and enhanced E2/ER-mediated venous relaxation would lead to more distensible veins in female rats. ..
  13. Chow E, Quach H, Zhang Y, Wang J, Evans D, Li A, et al. Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models. J Pharmacol Exp Ther. 2017;360:174-191 pubmed
  14. Li M, Chen W, Wang L, Sun J, Zhou L, Shi Y, et al. RLA8-A New and Highly Effective Quadruple PPAR-α/γ/δ and GPR40 Agonist to Reverse Nonalcoholic Steatohepatitis and Fibrosis. J Pharmacol Exp Ther. 2019;369:67-77 pubmed publisher
  15. Tolkach Y, Merseburger A, Herrmann T, Kuczyk M, Serth J, Imkamp F. Signatures of Adverse Pathological Features, Androgen Insensitivity and Metastatic Potential in Prostate Cancer. Anticancer Res. 2015;35:5443-51 pubmed
    ..surface associated (MUC1), MYC binding protein 2, E3 ubiquitin protein ligase (MYCBP2), somatostatin receptor 1 (SSTR1), topoisomerase (DNA) II alpha 170 kDa (TOP2A) and exportin 6 (XPO6)...
  16. Beneyto M, Morris H, Rovensky K, Lewis D. Lamina- and cell-specific alterations in cortical somatostatin receptor 2 mRNA expression in schizophrenia. Neuropharmacology. 2012;62:1598-605 pubmed publisher
    ..Thus, we used in situ hybridization to quantify the mRNA expression levels of SST receptors subtype 1 (SSTR1) and subtype 2 (SSTR2) in DLPFC area 9 from 23 matched pairs of subjects with schizophrenia and normal comparison ..
  17. Adori C, Glück L, Barde S, Yoshitake T, Kovacs G, Mulder J, et al. Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease. Acta Neuropathol. 2015;129:541-63 pubmed publisher
    ..We modeled these pathogenic changes in Sstr2(-/-) mice and, unlike in Sstr1(-/-) or Sstr4(-/-) genotypes, they showed selective, global and progressive degeneration of their central ..
  18. Husain B, Nanavaty I, Marathe S, Rajendran R, Vaidya V. Hippocampal transcriptional and neurogenic changes evoked by combination yohimbine and imipramine treatment. Prog Neuropsychopharmacol Biol Psychiatry. 2015;61:1-9 pubmed publisher
    ..expression of the α2A-adrenoceptor (Adra2a), serotonin 5HT2C receptor (Htr2c) and the somatostatin receptor 1 (Sstr1), which modulate antidepressant action...
  19. Yue Z, Yu M, Zhang X, Wang J, Ru S. The anti-androgenic effect of chronic exposure to semicarbazide on male Japanese flounder (Paralichthys olivaceus) and its potential mechanisms. Comp Biochem Physiol C Toxicol Pharmacol. 2018;210:30-34 pubmed publisher
  20. Hanafi N, Mohamed A, Sheikh Abdul Kadir S, Othman M. Overview of Bile Acids Signaling and Perspective on the Signal of Ursodeoxycholic Acid, the Most Hydrophilic Bile Acid, in the Heart. Biomolecules. 2018;8: pubmed publisher
    ..This review provides an overview of BA signaling, with the main emphasis on past and present perspectives on UDCA signals in the heart. ..
  21. Fatima A, Waters S, O Boyle P, Seoighe C, Morris D. Alterations in hepatic miRNA expression during negative energy balance in postpartum dairy cattle. BMC Genomics. 2014;15:28 pubmed publisher
    ..This study highlights the potential role of miRNAs in transcription regulation of hepatic gene expression during SNEB in dairy cattle. ..
  22. Kächele M, Hennige A, Machann J, Hieronimus A, Lamprinou A, Machicao F, et al. Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers. PLoS ONE. 2015;10:e0144494 pubmed publisher
    ..Even though the molecular pathways connecting PI3Kγ and HDL metabolism remain to be further elucidated, this finding could add a novel aspect to the pathophysiological role of PI3Kγ in atherogenesis. ..
  23. Mittal S, Khole S, Jagadish N, Ghosh D, Gadgil V, Sinkar V, et al. Andrographolide protects liver cells from H2O2 induced cell death by upregulation of Nrf-2/HO-1 mediated via adenosine A2a receptor signalling. Biochim Biophys Acta. 2016;1860:2377-2390 pubmed publisher
    ..We speculate that andrographolide can be used as a therapeutic drug to combat oxidative stress implicated in pathogenesis of various diseases such as diabetes, osteoporosis, neurodegenerative diseases etc. ..
  24. Dalmo J, Spetz J, Montelius M, Langen B, Arvidsson Y, Johansson H, et al. Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1. EJNMMI Res. 2017;7:6 pubmed publisher
    ..In vitro studies have shown that irradiation can up-regulate the expression of SSTR1, 2 and 5, and increase 177Lu-octreotate uptake...
  25. Strack J, Heni H, Gilsbach R, Hein L, Aktories K, Orth J. Noncanonical G-protein-dependent modulation of osteoclast differentiation and bone resorption mediated by Pasteurella multocida toxin. MBio. 2014;5:e02190 pubmed publisher
    ..In particular, modulation of G protein-coupled receptor activity in osteoclast progenitors by small molecules might be of specific interest. ..
  26. Parker B, Wertz S, Pollard C, Desimine V, Maning J, McCrink K, et al. Novel Insights into the Crosstalk between Mineralocorticoid Receptor and G Protein-Coupled Receptors in Heart Adverse Remodeling and Disease. Int J Mol Sci. 2018;19: pubmed publisher
    ..Novel findings revealing non-conventional roles of GPCR signaling molecules, specifically of GPCR-kinase (GRK)-5, in cardiac MR regulation are also highlighted. ..
  27. Ruggeri R, Ferrau F, Campenni A, Simone A, Barresi V, Giuffre G, et al. Immunohistochemical localization and functional characterization of somatostatin receptor subtypes in a corticotropin releasing hormone- secreting adrenal phaeochromocytoma: review of the literature and report of a case. Eur J Histochem. 2009;53:1-6 pubmed
    ..Immunostaining for SSTR subtypes showed a positive reaction for SSTR1, SSTR2A, SSTR2B, antisera on tumour cells...
  28. Howick K, Wallace Fitzsimons S, Kandil D, Chruscicka B, Caliş M, Murphy E, et al. A Dairy-Derived Ghrelinergic Hydrolysate Modulates Food Intake In Vivo. Int J Mol Sci. 2018;19: pubmed publisher
    ..Further mechanistic studies are required in order to confirm efficacy as a ghrelinergic bioactive in susceptible population groups. ..
  29. Zhu F, Ji X, Zhong X, Hu H, Liang L, Chen J, et al. [Effects of mild hypothermia on β-adrenergic signaling pathway in a cardiac arrest swine model]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018;30:134-139 pubmed publisher
    ..45±0.05 vs. 0.80±0.08, P < 0.05). Mild hypothermia can reduce the degree of cardiac function injury after CPR, and its mechanism may be related to the reduction of impaired myocardial β-AR signaling after CPR. ..
  30. Szolcsanyi J, Pinter E, Helyes Z, Petho G. Inhibition of the function of TRPV1-expressing nociceptive sensory neurons by somatostatin 4 receptor agonism: mechanism and therapeutical implications. Curr Top Med Chem. 2011;11:2253-63 pubmed
    ..for this function, experiments were focused on actions of sstR4 receptor agonists as this subtype, similarly to sstR1, is not involved in endocrine regulation...
  31. Mata K, Li W, Reslan O, Siddiqui W, Opsasnick L, Khalil R. Adaptive increases in expression and vasodilator activity of estrogen receptor subtypes in a blood vessel-specific pattern during pregnancy. Am J Physiol Heart Circ Physiol. 2015;309:H1679-96 pubmed publisher
    ..GPER may contribute to aortic relaxation while enhanced ER? expression could mediate other genomic vascular effects during pregnancy. ..
  32. Charron M, Vuguin P. Lack of glucagon receptor signaling and its implications beyond glucose homeostasis. J Endocrinol. 2015;224:R123-30 pubmed publisher
    ..These findings suggest that glucagon signaling plays an important role in multiple organs. Thus, treatment options designed to block Gcgr activation in diabetics may have implications beyond glucose homeostasis. ..
  33. De Buck M, Berghmans N, Pörtner N, Vanbrabant L, Cockx M, Struyf S, et al. Serum amyloid A1α induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils. J Leukoc Biol. 2015;98:1049-60 pubmed publisher
    ..g., lipopolysaccharide) inflammatory mediators induce primary chemoattractants such as serum amyloid A that synergize in an autocrine (monocyte) or a paracrine (neutrophil) fashion with secondary chemokines induced in stromal cells. ..
  34. Castillo Chabeco B, Figueroa G, Parira T, Napuri J, Agudelo M. Ethanol-induced modulation of GPR55 expression in human monocyte-derived dendritic cells is accompanied by H4K12 acetylation. Alcohol. 2018;71:25-31 pubmed publisher
  35. Liu H, Pathak P, Boehme S, Chiang J. Cholesterol 7?-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis. J Lipid Res. 2016;57:1831-1844 pubmed
    ..Maintaining bile acid and cholesterol homeostasis is important for protecting against liver injury and nonalcoholic fatty liver disease. ..
  36. Sizdahkhani S, Feldman M, Piazza M, Ksendzovsky A, Edwards N, Ray Chaudhury A, et al. Somatostatin receptor expression on von Hippel-Lindau-associated hemangioblastomas offers novel therapeutic target. Sci Rep. 2017;7:40822 pubmed publisher
    ..We explored this possibility by demonstrating consistent histologic expression of SSTR1, 2a, 4, and 5 in VHL-HBs...
  37. De Toni L, Di Nisio A, Speltra E, Rocca M, Ghezzi M, Zuccarello D, et al. Polymorphism rs2274911 of GPRC6A as a Novel Risk Factor for Testis Failure. J Clin Endocrinol Metab. 2016;101:953-61 pubmed publisher
    ..Our results suggest that GPRC6A inactivation or sub-function contributes to reduced exposure to androgens, leading to cryptorchidism during fetal life and/or low sperm production in adulthood. ..
  38. Guo D, Pan A, Dror R, Mocking T, Liu R, Heitman L, et al. Molecular Basis of Ligand Dissociation from the Adenosine A2A Receptor. Mol Pharmacol. 2016;89:485-91 pubmed publisher
    ..Our results also suggest that ZM241385 follows a multistep dissociation pathway, consecutively interacting with distinct receptor regions, a mechanism that may also be common to many other GPCRs. ..
  39. Murza A, Sainsily X, Côté J, Bruneau Cossette L, Besserer Offroy Ã, Longpré J, et al. Structure-activity relationship of novel macrocyclic biased apelin receptor agonists. Org Biomol Chem. 2017;15:449-458 pubmed publisher
    ..These macrocyclic compounds represent very useful pharmacological tools to explore the therapeutic potential of the apelinergic system. ..
  40. Kelliher C, Haase S. Connecting virulence pathways to cell-cycle progression in the fungal pathogen Cryptococcus neoformans. Curr Genet. 2017;63:803-811 pubmed publisher
  41. Mazaki Y, Onodera Y, Higashi T, Horinouchi T, Oikawa T, Sabe H. ARF1 recruits RAC1 to leading edge in neutrophil chemotaxis. Cell Commun Signal. 2017;15:36 pubmed publisher
  42. Schmid C, Kennedy N, Ross N, Lovell K, Yue Z, Morgenweck J, et al. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics. Cell. 2017;171:1165-1175.e13 pubmed publisher
  43. Marcinak J, Vakilynejad M, Kogame A, Tagawa Y. Evaluation of the Pharmacokinetics and Safety of a Single Oral Dose of Fasiglifam in Subjects with Mild or Moderate Hepatic Impairment. Drugs R D. 2018;18:109-118 pubmed publisher
    ..Hepatic status did not significantly impact systemic exposure of fasiglifam in this study, in fact, a decrease was observed, suggesting no dose reduction would be required for patients with hepatic impairment. ..
  44. Masyuk T, Masyuk A, Larusso N. TGR5 in the Cholangiociliopathies. Dig Dis. 2015;33:420-5 pubmed publisher
    ..Collectively, these data suggest the involvement of TGR5 in PLD and that TGR5 targeting in cystic cholangiocytes may have therapeutic potential. ..
  45. Ahlers K, Chakravarti B, Fisher R. RGS6 as a Novel Therapeutic Target in CNS Diseases and Cancer. AAPS J. 2016;18:560-72 pubmed publisher
    ..Together, these findings demonstrate the critical role of RGS6 in regulating both G protein-dependent CNS pathology and G protein-independent cancer pathology implicating RGS6 as a novel therapeutic target. ..
  46. Herr D, Reolo M, Peh Y, Wang W, Lee C, Rivera R, et al. Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy. Sci Rep. 2016;6:24541 pubmed publisher
    ..Cumulatively, these results suggest that S1P2 may serve as a therapeutic target for attenuating cisplatin-mediated ototoxicity. ..
  47. Dinh W, Albrecht Küpper B, Gheorghiade M, Voors A, van der Laan M, Sabbah H. Partial Adenosine A1 Agonist in Heart Failure. Handb Exp Pharmacol. 2017;243:177-203 pubmed publisher
  48. Traylor Knowles N, Rose N, Palumbi S. The cell specificity of gene expression in the response to heat stress in corals. J Exp Biol. 2017;220:1837-1845 pubmed publisher
    ..Joint information about expression patterns in response to heat and cell specificity will allow greater dissection of the regulatory pathways and specific cell reactions that lead to coral bleaching. ..
  49. Desplantes R, Leveque C, Müller B, Lotierzo M, Ferracci G, Popoff M, et al. Affinity biosensors using recombinant native membrane proteins displayed on exosomes: application to botulinum neurotoxin B receptor. Sci Rep. 2017;7:1032 pubmed publisher
    ..Engineered exosomes provide thus a novel means to study membrane proteins for biotechnology and clinical applications. ..
  50. Wang Y, Jin L, Song Y, Zhang M, Shan D, Liu Y, et al. ?-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signalling. Cardiovasc Res. 2017;113:1615-1626 pubmed publisher
    ..We define an upregulation of Arrb2 as a pathogenic factor in cardiac I/R injury, and also reveal a novel GPCR-independent mechanism of Arrb2-mediated cell death signalling in the heart. ..
  51. Abd Alla J, Graemer M, Fu X, Quitterer U. Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. J Biol Chem. 2016;291:2583-600 pubmed publisher
    ..Thus, GRK2 inhibition is a novel approach that targets the dysfunctional substrate metabolism of the failing heart. ..
  52. Trivellin G, Correa R, Batsis M, Faucz F, Chittiboina P, Bjelobaba I, et al. Screening for GPR101 defects in pediatric pituitary corticotropinomas. Endocr Relat Cancer. 2016;23:357-365 pubmed
    ..A rare germline GPR101 variant was found in one patient with CD but in vitro studies did not support a consistent pathogenic effect. GPR101 is unlikely to be involved in the pathogenesis of CD. ..
  53. Thompson A, Stephens J, Bain S, Kanamarlapudi V. Molecular Characterisation of Small Molecule Agonists Effect on the Human Glucagon Like Peptide-1 Receptor Internalisation. PLoS ONE. 2016;11:e0154229 pubmed publisher
    ..This study illustrates pharmacology of differential activation of GLP-1R by GLP-1 and compounds 2 and B. ..
  54. Chen Z, Wu D, Li L, Chen L. Apelin/APJ System: A Novel Therapeutic Target for Myocardial Ischemia/Reperfusion Injury. DNA Cell Biol. 2016;35:766-775 pubmed
    ..In this review, we discuss how the mechanisms of the apelin/APJ system reverse MIRI in detail and elaborate on APJ agonists, which may be used for therapy of MIRI. ..
  55. Booe J, Warner M, Roehrkasse A, Hay D, Pioszak A. Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists. Mol Pharmacol. 2018;93:355-367 pubmed publisher
  56. Minsel I, Mentlein R, Sel S, Diebold Y, Bräuer L, Muhlbauer E, et al. Somatostatin actions via somatostatin receptors on the ocular surface are modulated by inflammatory processes. Endocrinology. 2009;150:2254-63 pubmed publisher
    ..surface and in the lacrimal apparatus, we investigated the distribution pattern of SS and its receptors 1-5 (SSTR1-5) by means of RT-PCR, real-time RT-PCR, Western blot and immunodot blot analysis as well as immunohistochemistry ..
  57. Nakayama Y, Wada R, Yajima N, Hakamada K, Yagihashi S. Profiling of somatostatin receptor subtype expression by quantitative PCR and correlation with clinicopathological features in pancreatic endocrine tumors. Pancreas. 2010;39:1147-54 pubmed publisher
    ..The hormones and MIB1 index were examined using immunohistochemical techniques. The mRNA levels of SSTR1, SSTR2, SSTR3, and SSTR5 were high in PET compared with AC, whereas the expression of SSTR4 was low in PET and AC...
  58. Gao B, Huang Q, Jie Q, Lu W, Wang L, Li X, et al. GPR120: A bi-potential mediator to modulate the osteogenic and adipogenic differentiation of BMMSCs. Sci Rep. 2015;5:14080 pubmed publisher
    ..These findings provide new hope for developing novel remedies to treat osteoporosis by adjusting the GPR120-mediated differentiation balance of BMMSCs. ..
  59. Rosano C, Ponassi M, Santolla M, Pisano A, Felli L, Vivacqua A, et al. Macromolecular Modelling and Docking Simulations for the Discovery of Selective GPER Ligands. AAPS J. 2016;18:41-6 pubmed publisher
  60. Gautam A, Wang C, Zeng J, Wang J, Lu J, Wei J, et al. Expression and clinical significance of SALL4 and LGR5 in patients with lung cancer. Oncol Lett. 2015;10:3629-3634 pubmed
    ..By contrast, LGR5 demonstrated 97% sensitivity, but the specificity was poor. Therefore, SALL4 may be an extremely useful diagnostic marker for lung cancer, but LGR5 is not as useful. ..
  61. Fujimoto J, Nunomura Nakamura S, Liu Y, Lang W, McDowell T, Jakubek Y, et al. Development of Kras mutant lung adenocarcinoma in mice with knockout of the airway lineage-specific gene Gprc5a. Int J Cancer. 2017;141:1589-1599 pubmed publisher
  62. LeBlanc M, Lehmann R. Domain-specific control of germ cell polarity and migration by multifunction Tre1 GPCR. J Cell Biol. 2017;216:2945-2958 pubmed publisher
    ..We propose that this bifurcation of the Tre1 G protein-coupled receptor signaling response via G protein-dependent and independent branches enables distinct spatiotemporal regulation of germ cell migration. ..
  63. Chen G, Fu S, Feng W, Huang B, Xu S, Wang W, et al. AMP010014A09 in Sus Scrofa Encodes an Analog of G Protein-Coupled Receptor 109A, Which Mediates the Anti-Inflammatory Effects of Beta-Hydroxybutyric Acid. Cell Physiol Biochem. 2017;42:1420-1430 pubmed publisher
    ..Our results indicated that AMP+ encodes a G protein-coupled receptor in Sus scrofa that inhibits cAMP levels and mediates anti-inflammatory effects in swine monocytes. ..
  64. Fasciani A, Quilici P, Biscaldi E, Flamini M, Fioravanti A, Orlandi P, et al. Overexpression and functional relevance of somatostatin receptor-1, -2, and -5 in endometrium and endometriotic lesions. J Clin Endocrinol Metab. 2010;95:5315-9 pubmed publisher
    ..Thus, the use of these receptors may provide new strategies for the diagnosis and treatment of endometriosis. ..
  65. Li S, Yang C, Zhang L, Gao X, Wang X, Liu W, et al. Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling. Proc Natl Acad Sci U S A. 2016;113:1937-42 pubmed publisher
    ..Thus, our results provide a strategy to promote axon regeneration after CNS injury by modulating neuronal activity through GPCR signaling. ..
  66. Kamp M, Shim R, Nicholls A, Oliveira A, Mason L, Binge L, et al. G Protein-Coupled Receptor 43 Modulates Neutrophil Recruitment during Acute Inflammation. PLoS ONE. 2016;11:e0163750 pubmed publisher
    ..Therefore, GPR43 and a microbiota composition that allows for SCFA production function to modulate neutrophil recruitment during inflammatory responses. ..
  67. Liu H, Hou C, Wang G, Jia H, Yu H, Zeng X, et al. Lactobacillus reuteri I5007 Modulates Intestinal Host Defense Peptide Expression in the Model of IPEC-J2 Cells and Neonatal Piglets. Nutrients. 2017;9: pubmed publisher
  68. Piekielna Ciesielska J, Ferrari F, Calo G, Janecka A. Cyclopeptide Dmt-[D-Lys-p-CF3-Phe-Phe-Asp]NH2, a novel G protein-biased agonist of the mu opioid receptor. Peptides. 2018;101:227-233 pubmed publisher
    ..Such biased ligands are able to separate the biological actions of an activated receptor and have the potential to become more effective drug candidates with fewer side effects. ..
  69. Ahmed M, Bychkov E, Li L, Gurevich V, Gurevich E. GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson's disease via its RGS homology domain. Sci Rep. 2015;5:10920 pubmed publisher
    ..RH-dead mutant was ineffective, whereas GRK3 knockdown exacerbated ∆FosB accumulation. Our findings reveal a novel mechanism of GRK3 control of the dopamine receptor signaling and the role of Gq in LID. ..
  70. Friis K, Iturrioz X, Thomsen J, Alvear Perez R, Bahrami S, Llorens Cortes C, et al. Directed Molecular Evolution of an Engineered Gammaretroviral Envelope Protein with Dual Receptor Use Shows Stable Maintenance of Both Receptor Specificities. J Virol. 2016;90:1647-56 pubmed publisher
    ..We provide indirect evidence that such reduced affinity leads to reduced receptor internalization and propose a novel model in which too rapid receptor internalization may decrease virus entry. ..
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