Gene Symbol: SSRP1
Description: structure specific recognition protein 1
Alias: FACT, FACT80, T160, FACT complex subunit SSRP1, FACT 80 kDa subunit, FACTp80, chromatin-specific transcription elongation factor 80 kDa subunit, cisplatin-DNA SSRP, facilitates chromatin remodeling 80 kDa subunit, facilitates chromatin transcription complex 80 kDa subunit, facilitates chromatin transcription complex subunit SSRP1, hSSRP1, high mobility group box, recombination signal sequence recognition protein 1
Species: human
Products:     SSRP1

Top Publications

  1. Keller D, Zeng X, Wang Y, Zhang Q, Kapoor M, Shu H, et al. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Mol Cell. 2001;7:283-92 pubmed
    ..casein kinase 2 (CK2) and the chromatin transcriptional elongation factor FACT (a heterodimer of hSpt16 and SSRP1)...
  2. Bruhn S, Pil P, Essigmann J, Housman D, Lippard S. Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. Proc Natl Acad Sci U S A. 1992;89:2307-11 pubmed
    Human cDNA clones encoding a structure-specific recognition protein, SSRP1, that binds specifically to DNA modified with cisplatin have been isolated and characterized. The SSRP1 gene maps to human chromosome 11q12...
  3. Orphanides G, LeRoy G, Chang C, Luse D, Reinberg D. FACT, a factor that facilitates transcript elongation through nucleosomes. Cell. 1998;92:105-16 pubmed
    ..Entry into productive transcription required an accessory factor present in HeLa cell nuclear extract, FACT (facilitates chromatin transcription), which we have purified...
  4. Kelley D, Stokes D, Perry R. CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin. Chromosoma. 1999;108:10-25 pubmed
    ..We also present evidence for an in vivo interaction between CHD1 and a novel HMG box-containing protein, SSRP1, which involves an amino-terminal segment of CHD1 that does not include the chromodomain...
  5. Orphanides G, Wu W, Lane W, Hampsey M, Reinberg D. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. Nature. 1999;400:284-8 pubmed
    ..b>FACT (for facilitates chromatin transcription) is a chromatin-specific elongation factor required for transcription of ..
  6. Yarnell A, Oh S, Reinberg D, Lippard S. Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin. J Biol Chem. 2001;276:25736-41 pubmed
    The structure-specific recognition protein SSRP1, initially isolated from expression screening of a human B-cell cDNA library for proteins that bind to cisplatin (cis-diamminedichloroplatinum(II))-modified DNA, contains a single DNA-..
  7. Keller D, Lu H. p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. J Biol Chem. 2002;277:50206-13 pubmed
    ..weight protein complex containing the protein kinase CK2, along with the chromatin-associated factors hSPT16 and SSRP1. Here we determine that these proteins interact in vitro and in cells via non-overlapping domains and provide ..
  8. Belotserkovskaya R, Oh S, Bondarenko V, Orphanides G, Studitsky V, Reinberg D. FACT facilitates transcription-dependent nucleosome alteration. Science. 2003;301:1090-3 pubmed
    The FACT (facilitates chromatin transcription) complex is required for transcript elongation through nucleosomes by RNA polymerase II (Pol II) in vitro...
  9. Pavri R, Zhu B, Li G, Trojer P, Mandal S, Shilatifard A, et al. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell. 2006;125:703-17 pubmed RNF20/40 and UbcH6 is dependent on the transcription elongation regulator complex PAF, the histone chaperone FACT, and transcription...

More Information

Publications131 found, 100 shown here

  1. Tan B, Chien C, Hirose S, Lee S. Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication. EMBO J. 2006;25:3975-85 pubmed
    ..Here, we show that the heterodimeric transcriptional elongation factor FACT (facilitates chromatin transcription) is functionally linked to DNA synthesis...
  2. Heo K, Kim H, Choi S, Choi J, Kim K, Gu J, et al. FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell. 2008;30:86-97 pubmed publisher
    ..Here, we isolate the H2AX-associated factors, which include FACT (Spt16/SSRP1), DNA-PK, and PARP1 from a human cell line...
  3. Winkler D, Luger K. The histone chaperone FACT: structural insights and mechanisms for nucleosome reorganization. J Biol Chem. 2011;286:18369-74 pubmed publisher
    ..One member of this last class of factors, FACT (facilitates chromatin transcription), is categorized as a histone chaperone critical for nucleosome reorganization ..
  4. Tan B, Lee S. Nek9, a novel FACT-associated protein, modulates interphase progression. J Biol Chem. 2004;279:9321-30 pubmed
    The heterodimeric Spt16-Pob3/DUF/FACT complex is a class of chromatin structure modulators with important roles in replication and transcription...
  5. Li Y, Keller D, Scott J, Lu H. CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity. J Biol Chem. 2005;280:11869-75 pubmed
    We have previously shown that CK2 associates with the human high-mobility group protein SSRP1 and that this association increases in response to UV irradiation. CK2 also phosphorylates SSRP1 in vitro...
  6. Cardoso A, Fernandes A, Aguilar Pimentel J, de Angelis M, Guedes J, Brito M, et al. Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. Ageing Res Rev. 2018;47:214-277 pubmed publisher
    ..TGM2 (transglutaminase 2), (5) sRAGE (soluble receptor for advanced glycosylation end products), HMGB1 (high mobility group box 1), C3/C1Q (complement factor 3/1Q), ST2 (Interleukin 1 receptor like 1), agrin (AGRN), (6) IGF-1 (..
  7. Dong L, Han X, Tao X, Xu L, Xu Y, Fang L, et al. Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling. Foods. 2018;7: pubmed publisher
  8. Aslani F, Sebastian T, Keidel M, Fröhlich S, Elsässer H, Schuppe H, et al. Resistance to apoptosis and autophagy leads to enhanced survival in Sertoli cells. Mol Hum Reprod. 2017;23:370-380 pubmed publisher
    ..Extracellular high mobility group box protein one was measured as a marker of necrosis using ELISA...
  9. Valenza F, Coppola S, Froio S, Ruggeri G, Fumagalli J, Villa A, et al. A standardized model of brain death, donor treatment, and lung transplantation for studies on organ preservation and reconditioning. Intensive Care Med Exp. 2014;2:12 pubmed publisher
    ..factor alpha (TNFα), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interferon gamma (IFNγ), high mobility group box-1 (HMGB-1)), chemokines (chemokine CC motif ligand-2 (CCL2-MCP-1), chemokine CXC motif ligand-10 (CXCL-10)..
  10. Yu Y, Yang Y, Yang M, Wang C, Xie K, Yu Y. Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway. Int Immunopharmacol. 2019;69:11-18 pubmed publisher
  11. Wang H, Xu Y, Wang M, Cheng C, Bian R, Yuan H, et al. Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders. Int J Mol Med. 2017;39:819-830 pubmed publisher
    ..gene and protein expression, including interleukin (IL)-1?, IL-6, tumor necrosis factor (TNF)-?, HMGB1, high mobility group box 1 protein (HMGB1), cyclooxygenase-2 (COX-2), the Toll-like receptor 4 (TLR4)-myeloid differentiation ..
  12. Li P, Guo Y, Bledsoe G, Yang Z, Fan H, Chao L, et al. Kallistatin treatment attenuates lethality and organ injury in mouse models of established sepsis. Crit Care. 2015;19:200 pubmed publisher
    ..CLP-induced renal injury as well as blood urea nitrogen, serum creatinine, interleukin-6 (IL-6), and high mobility group box-1 (HMGB1) levels...
  13. Sun W, Jiao Y, Cui B, Gao X, Xia Y, Zhao Y. Immune complexes activate human endothelium involving the cell-signaling HMGB1-RAGE axis in the pathogenesis of lupus vasculitis. Lab Invest. 2013;93:626-38 pubmed publisher
    ..05). In conclusion, ICs elicit proinflammatory responses in human endothelial cells and alter their function involving cellular signaling via the HMGB1-RAGE axis in the pathogenesis of SLE vasculitis. ..
  14. Zhang B, Li S, Xie H, Fan J, Gu C, Kang C, et al. Effects of silencing the DUSP1 gene using lentiviral vector-mediated siRNA on the release of proinflammatory cytokines through regulation of the MAPK signaling pathway in mice with acute pancreatitis. Int J Mol Med. 2018;41:2213-2224 pubmed publisher
    ..of proinflammatory cytokines, including tumor necrosis factor (TNF)??, interleukin (IL)?1? and IL?6, high mobility group box 1 (HMGB1), and S100A12 in serum samples were detected using an enzyme?linked immunosorbent assay at 12, ..
  15. Gioia S, Sardo C, Castellani S, Porsio B, Belgiovine G, Carbone A, et al. From Genesis to Revelation: The Role of Inflammatory Mediators in Chronic Respiratory Diseases and their Control by Nucleic Acid-based Drugs. Curr Drug Deliv. 2017;14:253-271 pubmed publisher
  16. Nong K, Wang W, Niu X, Hu B, Ma C, Bai Y, et al. Hepatoprotective effect of exosomes from human-induced pluripotent stem cell-derived mesenchymal stromal cells against hepatic ischemia-reperfusion injury in rats. Cytotherapy. 2016;18:1548-1559 pubmed publisher
    ..Inflammatory markers, such as tumor necrosis factor (TNF)-?, interleukin (IL)-6 and high mobility group box 1 (HMGB1), were significantly reduced after administration of hiPSC-MSCs-Exo, which suggests that the ..
  17. Wang Y, Lin S, Chen W, Liao S, Wu C, Pan P, et al. Glechoma hederacea extracts attenuate cholestatic liver injury in a bile duct-ligated rat model. J Ethnopharmacol. 2017;204:58-66 pubmed publisher
    ..Further studies demonstrated an inhibitory effect of Glechoma hederacea extracts on the axis of high mobility group box-1 (HMGB1)/toll-like receptor-4 (TLR4) intracellular signaling pathways...
  18. Taniguchi N, Kawakami Y, Maruyama I, Lotz M. HMGB proteins and arthritis. Hum Cell. 2018;31:1-9 pubmed publisher
  19. Honda T, He Q, Wang F, Redington A. Acute and chronic remote ischemic conditioning attenuate septic cardiomyopathy, improve cardiac output, protect systemic organs, and improve mortality in a lipopolysaccharide-induced sepsis model. Basic Res Cardiol. 2019;114:15 pubmed publisher
    ..Our data also revealed that chronic RIC has additional benefit in terms of mortality in sepsis. While further studies are required, RIC may be a clinically useful tool to ameliorate sepsis-induced cardiomyopathy. ..
  20. Yoshihara Hirata C, Yamashiro K, Yamamoto T, Aoyagi H, Ideguchi H, Kawamura M, et al. Anti-HMGB1 Neutralizing Antibody Attenuates Periodontal Inflammation and Bone Resorption in a Murine Periodontitis Model. Infect Immun. 2018;86: pubmed publisher
    b>High mobility group box 1 (HMGB1) is a non-histone DNA-binding protein that is secreted into the extracellular milieu in response to inflammatory stimuli...
  21. Hong G, Zheng D, Zhang L, Ni R, Wang G, Fan G, et al. Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis. Free Radic Biol Med. 2018;123:125-137 pubmed publisher
    ..These protective effects of NR were associated with decreased levels of plasma high mobility group box-1 (HMGB1) in septic mice...
  22. Raucci A, Di Maggio S, Scavello F, D Ambrosio A, Bianchi M, Capogrossi M. The Janus face of HMGB1 in heart disease: a necessary update. Cell Mol Life Sci. 2019;76:211-229 pubmed publisher
    b>High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein involved in transcription regulation, DNA replication and repair and nucleosome assembly...
  23. Mazur Bialy A, Pochec E. Riboflavin Reduces Pro-Inflammatory Activation of Adipocyte-Macrophage Co-culture. Potential Application of Vitamin B2 Enrichment for Attenuation of Insulin Resistance and Metabolic Syndrome Development. Molecules. 2016;21: pubmed
  24. Han Q, Zhang H, Zhong B, Zhang B, Chen H. Antiapoptotic Effect of Recombinant HMGB1 A-box Protein via Regulation of microRNA-21 in Myocardial Ischemia-Reperfusion Injury Model in Rats. DNA Cell Biol. 2016;35:192-202 pubmed publisher
    The ~80 amino acid A box DNA-binding domain of high mobility group box 1 (HMGB1) protein antagonizes proinflammatory responses during myocardial ischemia reperfusion (I/R) injury...
  25. Wu D, Pan P, Liu B, Su X, Zhang L, Tan H, et al. Inhibition of Alveolar Macrophage Pyroptosis Reduces Lipopolysaccharide-induced Acute Lung Injury in Mice. Chin Med J (Engl). 2015;128:2638-45 pubmed publisher
    ..both in serum and BALF and reduced the levels of IL-18, tumor necrosis factor-α± (TNF-α±), High Mobility Group Box 1 (HMGB1) in BALF during LPS-induced ALI/ARDS...
  26. Volk Draper L, Hall K, Wilber A, Ran S. Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4. PLoS ONE. 2017;12:e0179257 pubmed publisher
    ..reprogrammed to the lymphatic phenotype by TLR4 ligands including lipopolysaccharide (LPS), recombinant high mobility group box 1 protein (HMGB1), and paclitaxel...
  27. Wang J, Xin L, Cheng W, Wang Z, Zhang W. [Effect of heat shock factor 1 on airway hyperresponsiveness and airway inflammation in mice with allergic asthma]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:222-228 pubmed
    ..05). Knockdown of HSF1 aggravates airway hyperresponsiveness and airway inflammation in asthmatic mice, and its possible mechanism may involve the negative regulation of HMGB1 and JNK. ..
  28. Pandolfi F, Altamura S, Frosali S, Conti P. Key Role of DAMP in Inflammation, Cancer, and Tissue Repair. Clin Ther. 2016;38:1017-28 pubmed publisher
    ..Due to the bivalent nature of DAMP, it is often difficult to explain the relative role of DAMP in inflammation versus its role in tissue repair. However, this point is crucial as DAMP-related treatments move into clinical practice. ..
  29. Goetzl E, Goetzl L, Karliner J, Tang N, Pulliam L. Human plasma platelet-derived exosomes: effects of aspirin. FASEB J. 2016;30:2058-63 pubmed publisher
    ..Goetzl, E. J., Goetzl, L., Karliner, J. S., Tang, N., Pulliam, L. Human plasma platelet-derived exosomes: effects of aspirin. ..
  30. Zhao H, Hao S, Xu H, Ma L, Zhang Z, Ni Y, et al. Protective role of nuclear factor erythroid 2-related factor 2 in the hemorrhagic shock-induced inflammatory response. Int J Mol Med. 2016;37:1014-22 pubmed publisher
    ..Taken together, these results suggest that Nrf2 is a critical host factor which limits immune dysregulation and organ injury following HS. ..
  31. Wu Q, Jiang D, Matsuda J, Ternyak K, Zhang B, Chu H. Cigarette Smoke Induces Human Airway Epithelial Senescence via Growth Differentiation Factor 15 Production. Am J Respir Cell Mol Biol. 2016;55:429-38 pubmed publisher
    ..Senescent airway epithelial cells that chronically accumulate in CS-exposed lungs could contribute substantially to chronic airway inflammation in COPD development and progression. ..
  32. Ohbe H, Kudo D, Yamanouchi S, Kushimoto S. Decreased a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 activity and neurologic outcome in patients with successful resuscitation of out-of-hospital cardiac arrest: A prospective observational study. J Crit Care. 2017;37:13-18 pubmed publisher
    ..These results suggest that ADAMTS13 may have pathophysiologic relevance in postcardiac arrest syndrome. ..
  33. Zagelbaum J, Shimazaki N, Esguerra Z, Watanabe G, Lieber M, Rothenberg E. Real-time analysis of RAG complex activity in V(D)J recombination. Proc Natl Acad Sci U S A. 2016;113:11853-11858 pubmed
    ..We show that high mobility group box 1 (HMGB1) acts as a cofactor in stabilizing conformational changes at the 12RSS heptamer and increasing ..
  34. Ugrinova I, Pasheva E. HMGB1 Protein: A Therapeutic Target Inside and Outside the Cell. Adv Protein Chem Struct Biol. 2017;107:37-76 pubmed publisher
  35. Sato A, Suzuki S, Watanabe S, Shimizu T, Nakamura Y, Misaka T, et al. DPP4 Inhibition Ameliorates Cardiac Function by Blocking the Cleavage of HMGB1 in Diabetic Mice After Myocardial Infarction. Int Heart J. 2017;58:778-786 pubmed publisher
    b>High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, promotes angiogenesis and tissue repair, resulting in restored cardiac function after myocardial infarction (MI)...
  36. Aoto K, Mimura K, Okayama H, Saito M, Chida S, Noda M, et al. Immunogenic tumor cell death induced by chemotherapy in patients with breast cancer and esophageal squamous cell carcinoma. Oncol Rep. 2018;39:151-159 pubmed publisher
    ..Our findings indicate that chemotherapy alone can significantly induce ICD regardless of the degree of pathological response after chemotherapy...
  37. Zhang S, Wang Z, Zhu J, Xu T, Zhao Y, Zhao H, et al. Carnosic Acid Alleviates BDL-Induced Liver Fibrosis through miR-29b-3p-Mediated Inhibition of the High-Mobility Group Box 1/Toll-Like Receptor 4 Signaling Pathway in Rats. Front Pharmacol. 2017;8:976 pubmed publisher
    ..Collectively, the results demonstrate that a miR-29b-3p/HMGB1/TLR4/NF-?B signaling pathway, which can be modulated by CA, is important in liver fibrosis, and indicate that CA might be a prospective therapeutic drug for liver fibrosis. ..
  38. Jiang Y, Shan S, Chi L, Zhang G, Gao X, Li H, et al. Methyl methanesulfonate induces necroptosis in human lung adenoma A549 cells through the PIG-3-reactive oxygen species pathway. Tumour Biol. 2016;37:3785-95 pubmed publisher
    ..cell death was also concurrent with the increased expression of p53, p53-induced gene 3 (PIG-3), high mobility group box-1 protein (HMGB1), and receptor interaction protein kinase (RIP) but not the apoptosis-associated caspase-..
  39. Maueröder C, Chaurio R, Dumych T, Podolska M, Lootsik M, Culemann S, et al. A blast without power - cell death induced by the tuberculosis-necrotizing toxin fails to elicit adequate immune responses. Cell Death Differ. 2016;23:1016-25 pubmed publisher
    ..These results demonstrate that the tissue microenvironment generated by dying cells may determine the subsequent immune response. ..
  40. Ren J, Meng S, Yan B, Yu J, Liu J. Protectin D1 reduces concanavalin A-induced liver injury by inhibiting NF-κB-mediated CX3CL1/CX3CR1 axis and NLR family, pyrin domain containing 3 inflammasome activation. Mol Med Rep. 2016;13:3627-38 pubmed publisher
    ..PD1 pretreatment was demonstrated to significantly inhibit elevated plasma aminotransferase levels, high mobility group box 1 and liver necrosis, which were observed in Con A‑induced hepatitis...
  41. Lee J, Yoon E, Seo J, Kavoussi A, Chung Y, Chung S, et al. Hypothermia inhibits the propagation of acute ischemic injury by inhibiting HMGB1. Mol Brain. 2016;9:81 pubmed publisher
    ..Hypothermia also prevents neurons in the infarct area from releasing high mobility group box 1 (HMGB1), the most well-studied damage-associated molecular pattern protein...
  42. Tang L, Chai W, Ye F, Yu Y, Cao L, Yang M, et al. HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cells. Oncotarget. 2017;8:27314-27327 pubmed publisher
    ..These findings demonstrate that released HMGB1 is central to DS, and that targeting HMGB1 may be of therapeutic value in the treatment of DS. ..
  43. Gao Y, Li C, Wei L, Teng Y, Nakajima S, Chen X, et al. SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming. Cancer Res. 2017;77:2674-2685 pubmed publisher
    ..The FACT complex comprised of the SSRP1 and SPT16 proteins is important for maintaining chromatin integrity, with SSRP1 acting as an histone H2A/H2B ..
  44. Sun P, Wang D, Zhou C, Tang Z, Liu W, Mu H. [The study of serum complements and proinflammatory cytokines in sepsis rats]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:364-367 pubmed publisher
    ..of serum complements (C5, C5a) and cytokines tumor necrosis factor-α (TNF-α), interleukin (IL-1, IL-6), high mobility group box 1 (HMGB1), macrophage migration inhibitory factor (MIF) were detected by enzyme linked immunosorbent ..
  45. Dong M, Zheng N, Ren L, Zhou H, Liu J. Increased expression of STIM1/Orai1 in platelets of stroke patients predictive of poor outcomes. Eur J Neurol. 2017;24:912-919 pubmed publisher
    ..had very high levels of biomarkers such as glycosylated hemoglobin, C-reactive protein, homocysteine and high mobility group box-1 protein (all P < 0.05)...
  46. Zhang Z, Chang Y, Zhang J, Lu Y, Zheng L, Hu Y, et al. HMGB3 promotes growth and migration in colorectal cancer by regulating WNT/?-catenin pathway. PLoS ONE. 2017;12:e0179741 pubmed publisher
    Colorectal cancer (CRC) is the third leading cause of cancer-related deaths and a major health problem. High mobility group box 3 (HMGB3), a member of the high-mobility group box (HMGB) family, was reported to be over-expressed in ..
  47. Wang B, Lian Y, Dong X, Peng W, Liu L, Su W, et al. Glycyrrhizic acid ameliorates the kynurenine pathway in association with its antidepressant effect. Behav Brain Res. 2018;353:250-257 pubmed publisher
    Our previous study implied the role of central high mobility group box 1 (HMGB1) in lipopolysaccharide (LPS)-induced depressive-like behaviors that could partially abrogate by glycyrrhizic acid (GZA)...
  48. Xue X, Chen X, Fan W, Wang G, Zhang L, Chen Z, et al. High-mobility group box 1 facilitates migration of neural stem cells via receptor for advanced glycation end products signaling pathway. Sci Rep. 2018;8:4513 pubmed publisher
  49. Chang K. Cilostazol inhibits HMGB1 release in LPS-activated RAW 264.7 cells and increases the survival of septic mice. Thromb Res. 2015;136:456-64 pubmed publisher
    ..factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase activity, and release of high mobility group box 1 (HMGB1) were analyzed using signal inhibitors and transfection techniques...
  50. Di Gioia S, Sardo C, Belgiovine G, Triolo D, D Apolito M, Castellani S, et al. Cationic polyaspartamide-based nanocomplexes mediate siRNA entry and down-regulation of the pro-inflammatory mediator high mobility group box 1 in airway epithelial cells. Int J Pharm. 2015;491:359-66 pubmed publisher
    ..In conclusion, we have found optimal conditions for down-regulation of HMGB1 by siRNA delivery mediated by polyaminoacidic polymers in airway epithelial cells in the absence of cytotoxicity. Functional and in-vivo studies are warranted. ..
  51. Wang W, Chen X, Zhang J, Zhao Y, Li S, Tan L, et al. Glycyrrhizin attenuates isoflurane-induced cognitive deficits in neonatal rats via its anti-inflammatory activity. Neuroscience. 2016;316:328-36 pubmed publisher
    ..These results suggest that glycyrrhizin may be a potential therapeutic agent for developmental neurotoxicity and subsequent cognitive decline induced by neonatal exposure to general anesthetics. ..
  52. De Caridi G, Bitto A, Massara M, Pallio G, Pizzino G, Serra R, et al. Increased Serum HMGB-1, ICAM-1 and Metalloproteinase-9 Levels in Buerger's Patients. Curr Vasc Pharmacol. 2016;14:382-7 pubmed
    ..This study was carried out to investigate HMGB-1 (high mobility group box-1), MMP (matrix metalloproteinase)- 2, MMP-9, MMP-11 and ICAM (intercellular adhesion molecule)-1 ..
  53. Qiu Y, Chen Y, Zeng T, Guo W, Zhou W, Yang X. High-mobility group box-B1 (HMGB1) mediates the hypoxia-induced mesenchymal transition of osteoblast cells via activating ERK/JNK signaling. Cell Biol Int. 2016;40:1152-1161 pubmed publisher
    ..In conclusion, our study demonstrated that HMGB1 induced the fibrosis of osteoblasts in vitro via activating the RAGE-MAPK and NF-?B interaction signaling pathways. ..
  54. Lee W, Ku S, Park S, Kim K, Choi H, Bae J. Inhibitory Effect of Three Diketopiperazines from Marine-Derived Bacteria on HMGB1-Induced Septic Responses in Vitro and in Vivo. Am J Chin Med. 2016;44:1145-1166 pubmed
    ..Collectively, these results indicated that 1-3 might act as potential therapeutic agents for various severe vascular inflammatory diseases through the inhibition of the HMGB1 signaling pathway. ..
  55. Das N, Dewan V, Grace P, Gunn R, Tamura R, Tzarum N, et al. HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia. Cell Rep. 2016;17:1128-1140 pubmed publisher
    Infectious and sterile inflammatory diseases are correlated with increased levels of high mobility group box 1 (HMGB1) in tissues and serum...
  56. Cheng Y, Xiong J, Chen Q, Xia J, Zhang Y, Yang X, et al. Hypoxia/reoxygenation-induced HMGB1 translocation and release promotes islet proinflammatory cytokine production and early islet graft failure through TLRs signaling. Biochim Biophys Acta Mol Basis Dis. 2017;1863:354-364 pubmed publisher
  57. Yu M, Yi S, Wu Y, Sun H, Song F, Wang J. Ddit3 suppresses the differentiation of mouse chondroprogenitor cells. Int J Biochem Cell Biol. 2016;81:156-163 pubmed publisher
    ..These results suggest that Ddit3 suppresses the differentiation of ATDC5 cells. The function of Ddit3 might partially be regulated by Sox9 expression during chondrogenic and hypertrophic differentiation. ..
  58. Sternberg Z, Sternberg D, Chichelli T, Drake A, Patel N, Kolb C, et al. High-mobility group box 1 in multiple sclerosis. Immunol Res. 2016;64:385-91 pubmed publisher
    ..07). HMGB1 serum levels showed 0.65 area under the curve (95 % CI 0.55-0.95) sensitivity/specificity for MS clinical relapse. The role of HMGB1 in MS disease pathology and DMD modulation of this protein warrant further investigations. ..
  59. Fonken L, Frank M, Kitt M, D Angelo H, Norden D, Weber M, et al. The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming. J Neurosci. 2016;36:7946-56 pubmed publisher
    ..The alarmin high mobility group box 1 (HMGB1) can be released under chronic pathological conditions and initiate inflammatory cascades...
  60. Bertheloot D, Latz E. HMGB1, IL-1?, IL-33 and S100 proteins: dual-function alarmins. Cell Mol Immunol. 2017;14:43-64 pubmed publisher
  61. Rosero O, Onody P, Kovacs T, Molnar D, Fülöp A, Lotz G, et al. Postconditioning: "Toll-erating" mesenteric ischemia-reperfusion injury?. Surgery. 2017;161:1004-1015 pubmed publisher
  62. Li Z, Li B, Niu L, Ge L. miR-592 functions as a tumor suppressor in human non-small cell lung cancer by targeting SOX9. Oncol Rep. 2017;37:297-304 pubmed publisher
    ..Furthermore, the gender determining region Y (SRY)-related high mobility group box 9 (SOX9) was confirmed as a direct target of miR-592, using luciferase reporter, qRT-PCR and western blot ..
  63. Ou Z, Chen Y, Niu X, He W, Song B, Fan D, et al. High-mobility group box 1 regulates cytoprotective autophagy in a mouse spermatocyte cell line (GC-2spd) exposed to cadmium. Ir J Med Sci. 2017;186:1041-1050 pubmed publisher
    ..Thus, the upregulation of HMGB1 increases LC3-II levels. Our data suggest that HMGB1-induced autophagy appears to act as a defense/survival mechanism against Cd cytotoxicity in GC-2spd cells. ..
  64. Simpson J, Lynch J, Loh Z, Zhang V, Werder R, Spann K, et al. The Absence of Interferon-β Promotor Stimulator-1 (IPS-1) Predisposes to Bronchiolitis and Asthma-like Pathology in Response to Pneumoviral Infection in Mice. Sci Rep. 2017;7:2353 pubmed publisher
    ..bronchiolitis, characterised by neutrophilic inflammation and necroptotic airway epithelial cell death, high mobility group box 1 (HMGB1) and IL-33 release, and downstream type-2 inflammation...
  65. Milani A, Bolhassani A, Shahbazi S, Motevalli F, Sadat S, Soleymani S. Small heat shock protein 27: An effective adjuvant for enhancement of HIV-1 Nef antigen-specific immunity. Immunol Lett. 2017;191:16-22 pubmed publisher
    ..Moreover, the endogenous adjuvants such as heat shock proteins (HSPs) and high mobility group box 1 protein (HMGB1) have been suggested effectively to induce antigen-specific humoral and cellular immune ..
  66. Tsujita R, Tsubota M, Hayashi Y, Saeki H, Sekiguchi F, Kawabata A. Role of Thrombin in Soluble Thrombomodulin-Induced Suppression of Peripheral HMGB1-Mediated Allodynia in Mice. J Neuroimmune Pharmacol. 2018;13:179-188 pubmed publisher
    b>High mobility group box 1 (HMGB1), a nuclear protein, once released into the extracellular space under pathological conditions, plays a pronociceptive role in redox-dependent distinct active forms, all-thiol HMGB1 (at-HMGB1) and ..
  67. Landais I, Lee H, Lu H. Coupling caspase cleavage and ubiquitin-proteasome-dependent degradation of SSRP1 during apoptosis. Cell Death Differ. 2006;13:1866-78 pubmed
    Structure-specific recognition protein (SSRP1) is an 87 kDa protein that heterodimerizes with Spt16 to form FACT, a complex initially shown to facilitate chromatin transcription...
  68. Fu J, Shi Q, Song X, Liu Z, Wang Y, Wang Y, et al. From the Cover: Tetrachlorobenzoquinone Exerts Neurological Proinflammatory Activity by Promoting HMGB1 Release, Which Induces TLR4 Clustering within the Lipid Raft. Toxicol Sci. 2016;153:303-15 pubmed publisher
    ..In summary, our current findings revealed a previously unknown mechanism of TCBQ-induced neurological inflammation related to HMGB1-TLR4 signaling. ..
  69. Carbone M, Kanodia S, Chao A, Miller A, Wali A, Weissman D, et al. Consensus Report of the 2015 Weinman International Conference on Mesothelioma. J Thorac Oncol. 2016;11:1246-1262 pubmed publisher
    ..populations is not currently available, novel biomarkers presented at the meeting, such as high mobility group box 1 and fibulin-3, are promising...
  70. Wang J, Han D, Sun M, Feng J. Cerebral ischemic post?conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model. Mol Med Rep. 2016;14:4162-4172 pubmed publisher
    ..The present study aimed to determine whether IPOC could inhibit autophagy and high mobility group box 1 (HMGB1) release in a PC12 cell oxygen glucose deprivation/reperfusion (OGD/R) model...
  71. Barić Rafaj R, Kuleš J, Marinculic A, Tvarijonaviciute A, Ceron J, Mihaljević Z, et al. Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs. BMC Vet Res. 2017;13:13 pubmed publisher
    ..Statistical analysis of high mobility group box - 1 protein (HMGB-1), soluble intercellular adhesive molecule -1 (sICAM-1) and plasminogen activator ..
  72. Fleyshman D, Prendergast L, Safina A, Paszkiewicz G, Commane M, Morgan K, et al. Level of FACT defines the transcriptional landscape and aggressive phenotype of breast cancer cells. Oncotarget. 2017;8:20525-20542 pubmed publisher
    ..Histone chaperone FACT, expressed in a limited number of normal cells, is overexpressed in different types of cancer, including BrCa...
  73. Wang X, Feng C, Qiao Y, Zhao X. Sigma 1 receptor mediated HMGB1 expression in spinal cord is involved in the development of diabetic neuropathic pain. Neurosci Lett. 2018;668:164-168 pubmed publisher
    No study has been conducted to examine the interactions of sigma-1 receptor (Sigma-1R) and high mobility group box 1 protein (HMGB1) in the development of diabetic peripheral neuropathy...
  74. Beebe S, Lassiter B, Guo S. Nanopulse Stimulation (NPS) Induces Tumor Ablation and Immunity in Orthotopic 4T1 Mouse Breast Cancer: A Review. Cancers (Basel). 2018;10: pubmed publisher
    ..may be responsible for release of danger-associated molecular patterns, including ATP, calreticulin, and high mobility group box 1 (HMBG1) from 4T1-Luc cells to induce immunogenic cell death (ICD)...
  75. Yang C, Song Y, Wang H. Suppression of RAGE and TLR9 by Ketamine Contributes to Attenuation of Lipopolysaccharide-Induced Acute Lung Injury. J Invest Surg. 2017;30:177-186 pubmed publisher
    ..The results presented here suggest that the protective mechanism of ketamine may be attributed partly to decreased production of inflammatory mediators through the inhibition of RAGE/TLR9-NF-?B pathway...
  76. Panday A, Grove A. Yeast HMO1: Linker Histone Reinvented. Microbiol Mol Biol Rev. 2017;81: pubmed controlled by the association of the intervening linker DNA with either the linker histone H1 or high mobility group box (HMGB) proteins...
  77. Bai Y, Du S, Li F, Huang F, Deng R, Zhou J, et al. Histone deacetylase-high mobility group box-1 pathway targeted by hypaconitine suppresses the apoptosis of endothelial cells. Exp Biol Med (Maywood). 2017;242:527-535 pubmed publisher
    ..carmichaelii is always used with caution in clinics. Thus, the identification of hypaconitine as an active component of A. carmichaelii could contribute to the development of toxicity-decreasing procedure for A. carmichaelii...
  78. Valieva M, Gerasimova N, Kudryashova K, Kozlova A, Kirpichnikov M, Hu Q, et al. Stabilization of Nucleosomes by Histone Tails and by FACT Revealed by spFRET Microscopy. Cancers (Basel). 2017;9: pubmed publisher
    ..C-terminal domain (CTD) and the high mobility group (HMG) domain of the structure-specific recognition protein 1 (SSRP1) subunit did not change the structure of the nucleosomes, while FACT without the acidic C-terminal domains of the ..
  79. Jeong W, Yang C, Roh T, Kim J, Lee J, Lee W. Scar Prevention and Enhanced Wound Healing Induced by Polydeoxyribonucleotide in a Rat Incisional Wound-Healing Model. Int J Mol Sci. 2017;18: pubmed publisher
    ..Thus, we believe that the anti-inflammatory and collagen synthesis effects of PDRN resulted in faster wound healing and decreased scar formation. ..
  80. Zhang S, Che D, Yang F, Chi C, Meng H, Shen J, et al. Tumor-associated macrophages promote tumor metastasis via the TGF-?/SOX9 axis in non-small cell lung cancer. Oncotarget. 2017;8:99801-99815 pubmed publisher
    ..number of TAMs present correlated positively with expression of sex determining region Y (SRY)-related high mobility group box 9 (SOX9) in NSCLC tissues...
  81. Huang J, Chen W, Chang Y, Wang H, Chuang W, Lee S. Modulation of nucleosome-binding activity of FACT by poly(ADP-ribosyl)ation. Nucleic Acids Res. 2006;34:2398-407 pubmed
    ..The FACT (facilitates chromatin transcription) complex, a heterodimer of hSpt16 and SSRP1, is a chromatin structure modulator whose involvement in transcription and DNA replication has been reported...
  82. Hu J, Liu E, Renne R. Involvement of SSRP1 in latent replication of Kaposi's sarcoma-associated herpesvirus. J Virol. 2009;83:11051-63 pubmed publisher
    ..Among these proteins, structure-specific recognition protein 1 (SSRP1), a subunit of the FACT complex, and telomeric repeat binding factor 2 (TRF2) formed complexes with LANA at the MR ..
  83. Prendergast L, Müller S, Liu Y, Huang H, Dingli F, Loew D, et al. The CENP-T/-W complex is a binding partner of the histone chaperone FACT. Genes Dev. 2016;30:1313-26 pubmed publisher
    ..Here, we found that CENP-T deposition at centromeres is uncoupled from DNA synthesis. We identified Spt16 and SSRP1, subunits of the H2A-H2B histone chaperone facilitates chromatin transcription (FACT), as CENP-W binding partners ..
  84. Cheng H, Wang W, Zhang Y, Zhang B, Cheng J, Teng P, et al. Expression levels and clinical significance of hepsin and HMGB1 proteins in cervical carcinoma. Oncol Lett. 2017;14:159-164 pubmed publisher
    This study assessed the hypothesis that the protein levels of high mobility group box 1 (HMGB1) and hepsin can be used as markers for diagnosis and prognosis in cervical carcinoma...
  85. Li J, Sun J, Rong R, Li L, Shang W, Song D, et al. HMGB1 promotes myeloid-derived suppressor cells and renal cell carcinoma immune escape. Oncotarget. 2017;8:63290-63298 pubmed publisher
    ..Meanwhile, it is confirmed that high mobility group box-1 protein (HMGB1) shows a high expression in many solid tumors and HMGB1 with high expression is involved ..
  86. Wong S, To J, Santos J, Allam V, Dalton J, Djordjevic S, et al. Proteomic Analysis of Extracellular HMGB1 Identifies Binding Partners and Exposes Its Potential Role in Airway Epithelial Cell Homeostasis. J Proteome Res. 2017;: pubmed publisher
    ..A1 (HMGA1), histone 3 (H3F3B), the FACT (facilitates chromatin transcription) complex constituents SUPT1H and SSRP1, and heterogeneous ribonucleoprotein K (HNRNPK)...
  87. Yamada Y, Nishikawa R, Kato M, Okato A, Arai T, Kojima S, et al. Regulation of HMGB3 by antitumor miR-205-5p inhibits cancer cell aggressiveness and is involved in prostate cancer pathogenesis. J Hum Genet. 2018;63:195-205 pubmed publisher
    ..Novel approaches to analysis of antitumor miRNA-regulated RNA networks in PCa cells may provide new insights into the pathogenic mechanisms of the disease. ..
  88. Okada M, Okawa K, Isobe T, Fukagawa T. CENP-H-containing complex facilitates centromere deposition of CENP-A in cooperation with FACT and CHD1. Mol Biol Cell. 2009;20:3986-95 pubmed publisher
    ..In conditional mutant cell lines for SSRP1, a subunit of FACT, centromere targeting of newly synthesized CENP-A is severely inhibited...
  89. Charles Richard J, Shukla M, Menoni H, Ouararhni K, Lone I, Roulland Y, et al. FACT Assists Base Excision Repair by Boosting the Remodeling Activity of RSC. PLoS Genet. 2016;12:e1006221 pubmed publisher
    b>FACT, in addition to its role in transcription, is likely implicated in both transcription-coupled nucleotide excision repair and DNA double strand break repair...
  90. Chen X, Li L, Khan M, Shi L, Wang Z, Zheng F, et al. HMGB1 exacerbates experimental mouse colitis by enhancing innate lymphoid cells 3 inflammatory responses via promoted IL-23 production. Innate Immun. 2016;22:696-705 pubmed publisher
    In inflammatory bowel diseases (IBD), high mobility group box 1 (HMGB1), as an endogenous inflammatory molecule, can promote inflammatory cytokines secretion by acting on TLR2/4 resulting in tissue damage...
  91. Komai K, Shichita T, Ito M, Kanamori M, Chikuma S, Yoshimura A. Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation. Int Immunol. 2017;29:59-70 pubmed publisher
    ..These data suggest that scavenger receptors function as co-receptors along with TLRs for HMGB1 in M1-type inflammatory macrophages. ..
  92. Biscetti F, Gentileschi S, Bertucci F, Servillo M, Arena V, Angelini F, et al. The angiogenic properties of human adipose-derived stem cells (HASCs) are modulated by the High mobility group box protein 1 (HMGB1). Int J Cardiol. 2017;249:349-356 pubmed publisher
    ..The High mobility group box 1 protein (HMGB1) is a nuclear protein involved in angiogenesis...