SRY

Summary

Gene Symbol: SRY
Description: sex determining region Y
Alias: SRXX1, SRXY1, TDF, TDY, sex-determining region Y protein, essential protein for sex determination in human males, sex-determining region on Y, testis-determining factor on Y, truncated sex-determining region Y protein
Species: human
Products:     SRY

Top Publications

  1. Poulat F, de Santa Barbara P, Desclozeaux M, Soullier S, Moniot B, Bonneaud N, et al. The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains. J Biol Chem. 1997;272:7167-72 pubmed
    The human Y-linked testis determining gene SRY encodes a protein with a DNA binding domain from the high mobility group box family. To date, no function has been assigned to amino acid sequences located outside this DNA binding motif...
  2. Sudbeck P, Scherer G. Two independent nuclear localization signals are present in the DNA-binding high-mobility group domains of SRY and SOX9. J Biol Chem. 1997;272:27848-52 pubmed
    b>SRY and SOX9, members of the family of high-mobility group (HMG) domain transcription factors, are both essential for testis formation during human embryonic development...
  3. Hossain A, Saunders G. The human sex-determining gene SRY is a direct target of WT1. J Biol Chem. 2001;276:16817-23 pubmed
    ..In this study we investigated the regulation of the sex determination gene SRY by WT1...
  4. Assumpção J, Benedetti C, Maciel Guerra A, Guerra G, Baptista M, Scolfaro M, et al. Novel mutations affecting SRY DNA-binding activity: the HMG box N65H associated with 46,XY pure gonadal dysgenesis and the familial non-HMG box R30I associated with variable phenotypes. J Mol Med (Berl). 2002;80:782-90 pubmed
    The SRY gene (sex-determining region of the Y chromosome) initiates the process of male sex differentiation in mammalians. In humans mutations in the SRY gene have been reported to account for 10-15% of the XY sex reversal cases...
  5. Boyer A, Pilon N, Raiwet D, Lussier J, Silversides D. Human and pig SRY 5' flanking sequences can direct reporter transgene expression to the genital ridge and to migrating neural crest cells. Dev Dyn. 2006;235:623-32 pubmed
    ..In eutherian mammals, sex determination is genetic, and SRY is the Y chromosome located gene representing the dominant testes determining factor...
  6. Sekido R, Lovell Badge R. Sex determination and SRY: down to a wink and a nudge?. Trends Genet. 2009;25:19-29 pubmed publisher
    Sex-determining region Y (Sry) is the crucial gene that initiates male sex determination in most mammals...
  7. Domenice S, Yumie Nishi M, Correia Billerbeck A, Latronico A, Aparecida Medeiros M, Russell A, et al. A novel missense mutation (S18N) in the 5' non-HMG box region of the SRY gene in a patient with partial gonadal dysgenesis and his normal male relatives. Hum Genet. 1998;102:213-5 pubmed
    Mutations in the sex-determining region of the Y chromosome (the SRY gene) have been reported in low frequency in patients with 46,XY gonadal dysgenesis...
  8. Ohe K, Lalli E, Sassone Corsi P. A direct role of SRY and SOX proteins in pre-mRNA splicing. Proc Natl Acad Sci U S A. 2002;99:1146-51 pubmed
    The mammalian testis determining factor SRY and its related Sox factors are critical developmental regulators...
  9. Uehara S, Hashiyada M, Sato K, Nata M, Funato T, Okamura K. Complete XY gonadal dysgenesis and aspects of the SRYgenotype and gonadal tumor formation. J Hum Genet. 2002;47:279-84 pubmed
    ..from embryonic testicular regression sequences and is induced by mutations in the sex-determining region Y ( SRY) gene. The incidence of SRY mutations is thought to be approximately 20%...

More Information

Publications101 found, 100 shown here

  1. Harley V, Layfield S, Mitchell C, Forwood J, John A, Briggs L, et al. Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations. Proc Natl Acad Sci U S A. 2003;100:7045-50 pubmed
    The architectural transcription factor SRY (sex-determining region of the Y chromosome) plays a key role in sex determination as indicated by the fact that mutations in SRY are responsible for XY gonadal dysgenesis in humans...
  2. Premi S, Srivastava J, Chandy S, Ahmad J, Ali S. Tandem duplication and copy number polymorphism of the SRY gene in patients with sex chromosome anomalies and males exposed to natural background radiation. Mol Hum Reprod. 2006;12:113-21 pubmed
    Mutations in the SRY gene encompassing the HMG box have been well characterized in gonadal dysgenesis, male infertility and other types of sex chromosome related anomalies (SCRA)...
  3. Bernard P, Sim H, Knower K, Vilain E, Harley V. Human SRY inhibits beta-catenin-mediated transcription. Int J Biochem Cell Biol. 2008;40:2889-900 pubmed publisher
    In most mammals, sex is determined by the presence or absence of the SRY gene...
  4. Lau Y, Li Y. The human and mouse sex-determining SRY genes repress the Rspol/beta-catenin signaling. J Genet Genomics. 2009;36:193-202 pubmed publisher
    The sex-determining region Y (SRY) is the gene on the Y chromosome responsible for switching on male sex determination during mammalian embryogenesis. In its absence, ovaries develop in the embryo...
  5. Sinclair A, Berta P, Palmer M, Hawkins J, Griffiths B, Smith M, et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature. 1990;346:240-4 pubmed
    ..This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene, TDF.
  6. Berta P, Hawkins J, Sinclair A, Taylor A, Griffiths B, Goodfellow P, et al. Genetic evidence equating SRY and the testis-determining factor. Nature. 1990;348:448-50 pubmed
    The testis-determining factor gene (TDF) lies on the Y chromosome and is responsible for initiating male sex determination...
  7. Werner M, Huth J, Gronenborn A, Clore G. Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex. Cell. 1995;81:705-14 pubmed
    The solution structure of the specific complex between the high mobility group (HMG) domain of SRY (hSRY-HMG), the protein encoded by the human testis-determining gene, and its DNA target site in the promoter of the müllerian inhibitory ..
  8. Poulat F, Girard F, Chevron M, Goze C, Rebillard X, Calas B, et al. Nuclear localization of the testis determining gene product SRY. J Cell Biol. 1995;128:737-48 pubmed
    We have studied the expression of the human SRY protein (termed p27SRY) in two different cell lines by using specific antibodies. Confocal microscopy enabled us to localize p27SRY precisely in the nucleus in a discrete punctuate pattern...
  9. Whitfield L, Lovell Badge R, Goodfellow P. Rapid sequence evolution of the mammalian sex-determining gene SRY. Nature. 1993;364:713-5 pubmed
    In mammals, induction of male sex determination requires the Y-chromosome gene SRY. SRY encodes a protein with a central 'high mobility group' domain (HMG box) of about 78 amino acids...
  10. Desclozeaux M, Poulat F, de Santa Barbara P, Capony J, Turowski P, Jay P, et al. Phosphorylation of an N-terminal motif enhances DNA-binding activity of the human SRY protein. J Biol Chem. 1998;273:7988-95 pubmed
    ..To conclusively demonstrate that the human sex-determining gene SRY is affected by such a post-translational control mechanism, we have analyzed its phosphorylation status in living ..
  11. Oh H, Li Y, Lau Y. Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. Biol Reprod. 2005;72:407-15 pubmed
    In mammals, the SRY/Sry gene on the Y chromosome is necessary and sufficient for a bipotential gonad to develop into a testis, regardless of its chromosomal sex...
  12. Ferrari S, Harley V, Pontiggia A, Goodfellow P, Lovell Badge R, Bianchi M. SRY, like HMG1, recognizes sharp angles in DNA. EMBO J. 1992;11:4497-506 pubmed
    ..We show here also that the HMG box of SRY, the protein that determines the expression of male-specific genes in humans, recognizes four-way junction DNAs ..
  13. Harley V, Jackson D, Hextall P, Hawkins J, Berkovitz G, Sockanathan S, et al. DNA binding activity of recombinant SRY from normal males and XY females. Science. 1992;255:453-6 pubmed
    The protein encoded by the human testis determining gene, SRY, contains a high mobility group (HMG) box related to that present in the T cell-specific, DNA-binding protein TCF-1...
  14. Cameron F, Sinclair A. Mutations in SRY and SOX9: testis-determining genes. Hum Mutat. 1997;9:388-95 pubmed
  15. Canto P, de la Chesnaye E, Lopez M, Cervantes A, Chavez B, Vilchis F, et al. A mutation in the 5' non-high mobility group box region of the SRY gene in patients with Turner syndrome and Y mosaicism. J Clin Endocrinol Metab. 2000;85:1908-11 pubmed
    ..Mutations of SRY (testis-determining gene) constitute the cause of XY sex reversal in approximately 10-15% of females with pure ..
  16. Murphy E, Zhurkin V, Louis J, Cornilescu G, Clore G. Structural basis for SRY-dependent 46-X,Y sex reversal: modulation of DNA bending by a naturally occurring point mutation. J Mol Biol. 2001;312:481-99 pubmed
    The HMG-box domain of the human male sex-determining factor SRY, hSRY(HMG) (comprising residues 57-140 of the full-length sequence), binds DNA sequence-specifically in the minor groove, resulting in substantial DNA bending...
  17. Bashamboo A, Rahman M, Prasad A, Chandy S, Ahmad J, Ali S. Fate of SRY, PABY, DYS1, DYZ3 and DYZ1 loci in Indian patients harbouring sex chromosomal anomalies. Mol Hum Reprod. 2005;11:117-27 pubmed
    ..assays and screened genomic DNA of 34 patients with or without detectable Y chromosome for the presence/absence of SRY, PABY, DYS1, DYZ3 and DYZ1 loci and for mutations in the SRY gene...
  18. Sekido R, Lovell Badge R. Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer. Nature. 2008;453:930-4 pubmed publisher
    The mammalian Y chromosome acts as a dominant male determinant as a result of the action of a single gene, Sry, whose role in sex determination is to initiate testis rather than ovary development from early bipotential gonads...
  19. Wu Q, Li N, Li W, Li T, Zhang C, Cui Y, et al. Clinical, molecular and cytogenetic analysis of 46, XX testicular disorder of sex development with SRY-positive. BMC Urol. 2014;14:70 pubmed publisher
    ..reversal by investigating the clinical characteristics and their relationships with chromosomal karyotype and the SRY(sex-determining region Y)gene. Five untreated 46, XX patients with SRY-positive were referred for infertility...
  20. Jørgensen A, Nielsen J, Perlman S, Lundvall L, Mitchell R, Juul A, et al. Ex vivo culture of human fetal gonads: manipulation of meiosis signalling by retinoic acid treatment disrupts testis development. Hum Reprod. 2015;30:2351-63 pubmed publisher
    ..transcription factor 4 (OCT4), transcription factor AP-2 gamma (AP2γ) (embryonic germ cell markers), SRY (sex determining region Y)-box 9 (SOX9), anti-Müllerian hormone (AMH) (immature Sertoli cell markers), COUP ..
  21. Mazzio E, Lewis C, Soliman K. Transcriptomic Profiling of MDA-MB-231 Cells Exposed to Boswellia Serrata and 3-O-Acetyl-B-Boswellic Acid; ER/UPR Mediated Programmed Cell Death. Cancer Genomics Proteomics. 2017;14:409-425 pubmed
    ..Among these are cell migration-inducing protein hyaluronan binding (CEMIP) [-7.22]; transglutaminase 2 [-4.96], SRY box 9 (SOX9) [-4.09], inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1) [-6...
  22. Sivashankar S, Sapsanis C, Agambayev S, Büttner U, Salama K. Label-free detection of sex determining region Y (SRY) via capacitive biosensor. Conf Proc IEEE Eng Med Biol Soc. 2016;2016:4349-4352 pubmed publisher
    ..the use of a simple fractal capacitive biosensor for the quantification and detection of sex-determining region Y (SRY) genes...
  23. Berthouly C, Maillard J, Pham Doan L, Nhu Van T, Bed Hom B, LeRoy G, et al. Revealing fine scale subpopulation structure in the Vietnamese H'Mong cattle breed for conservation purposes. BMC Genet. 2010;11:45 pubmed publisher
    ..Single-nucleotide polymorphisms (SNP) of the SRY gene and mtDNA D-Loop sequence were analysed to clarify the origin of the breed...
  24. Çatlı G, Alparslan C, Can P, Akbay S, Kelekçi S, AtIk T, et al. An Unusual Presentation of 46,XY Pure Gonadal Dysgenesis: Spontaneous Breast Development and Menstruation. J Clin Res Pediatr Endocrinol. 2015;7:159-62 pubmed publisher
    ..Pelvic ultrasonography showed small gonads and a normal sized uterus for age. SRY gene expression was confirmed by multiplex polymerase chain reaction...
  25. Pérez Gutiérrez J, Monteagudo L, Rodríguez Bertos A, García Pérez E, Sánchez Calabuig M, García Botey C, et al. Bilateral Ovotestes in a 78, XX SRY-Negative Beagle Dog. J Am Anim Hosp Assoc. 2015;51:267-71 pubmed publisher
    ..In summary, the dog presented bilateral ovotestes and a 2n = 78, XX chromosomal complement lacking the sex determining region Y gene, consistent with a diagnosis of true hermaphroditism. ..
  26. Gulick R, Wilkin T, Chen Y, Landovitz R, Amico K, Young A, et al. Phase 2 Study of the Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Men Who Have Sex With Men (HPTN 069/ACTG A5305). J Infect Dis. 2017;215:238-246 pubmed publisher
    ..conducted, comparing 4 regimens: MVC alone, MVC plus emtricitabine (FTC), MVC plus tenofovir disoproxil fumarate (TDF), and TDF plus FTC...
  27. Mingione A, Maruca K, Chiappori F, Pivari F, Brasacchio C, Quirino T, et al. High parathyroid hormone concentration in tenofovir-treated patients are due to inhibition of calcium-sensing receptor activity. Biomed Pharmacother. 2018;97:969-974 pubmed publisher
    ..hormone (PTH) concentration in patients on antiretroviral treatment containing tenofovir disoproxil fumarate (TDF) has been reported. Hyperparathyroidism was not always sustained by a reduction in vitamin D concentration...
  28. Tan Z, Jia X, Ma F, Feng Y, Lu H, Jin J, et al. Increased MMAB level in mitochondria as a novel biomarker of hepatotoxicity induced by Efavirenz. PLoS ONE. 2017;12:e0188366 pubmed publisher
    ..The effects of other anti-HIV drugs (nevirapine (NVP) and tenofovirdisoproxil (TDF)), and hydrogen peroxide (H2O2) were also tested...
  29. Gianotti N, Galli L, Poli A, Salpietro S, Nozza S, Carbone A, et al. Estimated Glomerular Filtration Rate Trajectories in HIV-Infected Subjects Treated With Different Ritonavir-Boosted Protease Inhibitors and Tenofovir Disoproxil Fumarate or Abacavir. Medicine (Baltimore). 2016;95:e3780 pubmed publisher
    ..different protease inhibitors (PIs) or a non-nucleoside reverse transcriptase inhibitor (NNRTI) plus tenofovir (TDF) or abacavir (ABC) and lamivudine or emtricitabine (xTC)...
  30. Jotwani V, Scherzer R, Estrella M, Jacobson L, Witt M, Palella F, et al. HIV Infection, Tenofovir, and Urine ?1-Microglobulin: A Cross-sectional Analysis in the Multicenter AIDS Cohort Study. Am J Kidney Dis. 2016;68:571-581 pubmed publisher
    Tenofovir disoproxil fumarate (TDF) can cause proximal tubular damage and chronic kidney disease in human immunodeficiency virus (HIV)-infected individuals...
  31. Bax M, Johnson T, Harms P, Schwartz J, Zhao L, Fullen D, et al. Detection of Occult Invasion in Melanoma In Situ. JAMA Dermatol. 2016;152:1201-1208 pubmed publisher
    ..Melan-A-stained slides showing definitive invasion were double-stained with Sry-related HMg-Box gene 10 (SOX10) to confirm the melanocytic nature of the cells of interest...
  32. Rhee S, Varghese V, Holmes S, van Zyl G, Steegen K, Boyd M, et al. Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration. EBioMedicine. 2017;18:225-235 pubmed publisher
    Tenofovir disoproxil fumarate (TDF) genotypic resistance defined by K65R/N and/or K70E/Q/G occurs in 20% to 60% of individuals with virological failure (VF) on a WHO-recommended TDF-containing first-line regimen...
  33. McCullough L, Mirza M, Xu Y, Bentivegna K, Steffens E, Ritzel R, et al. Stroke sensitivity in the aged: sex chromosome complement vs. gonadal hormones. Aging (Albany NY). 2016;8:1432-41 pubmed publisher
    ..chromosome complement and gonadal hormones to stroke sensitivity in aged mice in which the testis determining gene (Sry) is removed from the Y chromosome, allowing for the generation of XX males and XY females...
  34. Havens P, Stephensen C, Van Loan M, Schuster G, Woodhouse L, Flynn P, et al. Decline in Bone Mass With Tenofovir Disoproxil Fumarate/Emtricitabine Is Associated With Hormonal Changes in the Absence of Renal Impairment When Used by HIV-Uninfected Adolescent Boys and Young Men for HIV Preexposure Prophylaxis. Clin Infect Dis. 2017;64:317-325 pubmed publisher
    We aimed to define the relative importance of renal and endocrine changes in tenofovir disoproxil fumarate (TDF)-related bone toxicity...
  35. Neustetter M, Mahmoodi Darian M, Denifl S. Study of Electron Ionization and Fragmentation of Non-hydrated and Hydrated Tetrahydrofuran Clusters. J Am Soc Mass Spectrom. 2017;28:866-872 pubmed publisher
    ..For elucidation of fragmentation pathways, deuterated TDF (C4D8O) was investigated as well...
  36. Song Y, Liu T, Wang Y, Deng J, Chen M, Yuan L, et al. Mutation of the Sp1 binding site in the 5' flanking region of SRY causes sex reversal in rabbits. Oncotarget. 2017;8:38176-38183 pubmed publisher
    ..Mutations of the Sp1-binding site in the 5' flanking region of SRY are associated with clinical male-to-female sex reversal syndrome, although such occurrences are rare and, until ..
  37. Soresi D, Carrera A, Echenique V, Garbus I. Identification of genes induced by Fusarium graminearum inoculation in the resistant durum wheat line Langdon(Dic-3A)10 and the susceptible parental line Langdon. Microbiol Res. 2015;177:53-66 pubmed publisher
    ..For instance, three TDF-associated genes contained binding sites for WRKY transcription factors, which have been implicated in the ..
  38. Wang Y, Yang Q, Liu W, Yu M, Zhang Z, Cui X. Di(2-Ethylhexyl) Phthalate Exposure In Utero Damages Sertoli Cell Differentiation Via Disturbance of Sex Determination Pathway in Fetal and Postnatal Mice. Toxicol Sci. 2016;152:53-61 pubmed publisher
    ..And SRY-related HMG box 9 (SOX9), Fibroblast growth factor-9 (FGF9), and Double-sex and Mab-3 related transcripttion factor ..
  39. Shishido Y, Baba T, Sato T, Shima Y, Miyabayashi K, Inoue M, et al. Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells. Sci Rep. 2017;7:41912 pubmed publisher
    b>SRY, a sex-determining gene, induces testis development in chromosomally female (XX) individuals...
  40. Aimaiti Y, Jin X, Wang W, Chen Z, Li D. TGF-?1 signaling regulates mouse hepatic stellate cell differentiation via the Jagged1/Notch pathway. Life Sci. 2018;192:221-230 pubmed publisher
    ..SMA), Jagged1 and the differentiation markers alpha-fetoprotein (AFP), albumin (ALB), cytokeratin19 (CK19), SRY (sex determining region Y)-box 9 (SOX9), and hairy and enhancer of split-1 (Hes1) were measured with qRT-PCR and ..
  41. Quinet J, Jamard C, Burtin M, Lemasson M, Guerret S, Sureau C, et al. Nucleic acid polymer REP 2139 and nucleos(t)ide analogues act synergistically against chronic hepadnaviral infection in vivo. Hepatology. 2017;: pubmed publisher
    ..In this preclinical study, a novel combination therapy consisting of REP 2139 with tenofovir disoproxil fumarate (TDF) and entecavir (ETV) was evaluated in vivo in the chronic DHBV infection model...
  42. LaFleur J, Bress A, Myers J, Rosenblatt L, Crook J, Knippenberg K, et al. Tenofovir-Associated Bone Adverse Outcomes among a US National Historical Cohort of HIV-Infected Veterans: Risk Modification by Concomitant Antiretrovirals. Infect Dis Ther. 2018;7:293-308 pubmed publisher
    Tenofovir disoproxil fumarate (TDF) has been associated with greater incidences of bone complications, which might be modified by some concomitantly administered antiretrovirals, possibly by their effect on tenofovir concentrations...
  43. Stewart C, Baker E, Beaton C, Crook M, Peverall J, Wallace S. Detection of Y-chromosome in gonadal tumours using fluorescence in situ hybridization: diagnostic value in intersex conditions including older patients with clinically unsuspected androgen insensitivity syndrome. Histopathology. 2008;52:175-82 pubmed publisher
    To evaluate fluorescence in situ hybridization (FISH) for SRY, the testis-determining gene on the Y-chromosome, in gonadal specimens from patients with intersex disorders including two older individuals presenting with Sertoli cell ..
  44. Du W, Hu J, Du W, Klein O. Lineage tracing of epithelial cells in developing teeth reveals two strategies for building signaling centers. J Biol Chem. 2017;292:15062-15069 pubmed publisher
    ..epithelial populations, we found that the EK of the mouse incisor is derived de novo from a group of SRY-box 2 (Sox2)-expressing cells in the posterior half of the tooth germ...
  45. Moreno Guillén S, Losa García J, Berenguer Berenguer J, Martínez Sesmero J, Cenoz Gomis S, Graefenhain R, et al. Cost-utility analysis of the fixed-dose combination of dolutegravir/abacavir/lamivudine as initial treatment of HIV+ patients in Spain. Farm Hosp. 2017;41:601-610 pubmed publisher
    ..of the fixed-dose combination of (DTG/ABC/3TC) versus the combinations emtricitabine/tenofovir/efavirenz (FTC/TDF/EFV), and darunavir/r (DRV/r) or raltegravir (RAL) with emtricitabine/tenofovir (FTC/TDF) or abacavir/lamivudine (..
  46. Weatherson K, McKay R, Gainforth H, Jung M. Barriers and facilitators to the implementation of a school-based physical activity policy in Canada: application of the theoretical domains framework. BMC Public Health. 2017;17:835 pubmed publisher
    ..This study used the Theoretical Domains Framework (TDF) to understand teachers' barriers and facilitators to the implementation of the DPA policy in one school district...
  47. Zhang S, Wu M, Peng C, Lv Y, Wu D, Liu J, et al. Improvements in neuroelectrophysiological and rear limb functions in rats with spinal cord injury after Schwann cell transplantation in combination with a C5a receptor antagonist. Genet Mol Res. 2015;14:15158-68 pubmed publisher
    ..Sex-determining region Y (SRY) gene expression was measured at week 4 and horseradish peroxidase (HRP) labeling was used at week 8 to further ..
  48. Jiang J, Wang J, Zhong F, Chen G, Li Y, Zheng X. Combined PCR and Q-RT-PCR technique for detecting chimerism in a non-human Primate vascularized osteomyocutaneous allografts model. Cell Mol Biol (Noisy-le-grand). 2016;62:31-5 pubmed
    ..reaction (RT-PCR) and real-time quantitative PCR (qRT-PCR) technique using primers specific for Macaca fascicularis sex determination region on the Y chromosome (SRY) gene. With the method, we estimated the level of the chimerism.
  49. Lee S, Ahn S, Jung K, Kim D, Kim B, Kim S, et al. Tenofovir versus tenofovir plus entecavir for chronic hepatitis B with lamivudine resistance and entecavir resistance. J Viral Hepat. 2017;24:141-147 pubmed publisher
    We compared the viral suppressive efficacy of tenofovir disoproxil fumarate (TDF) mono-rescue therapy (TDF group) and TDF plus entecavir (ETV) combination-rescue therapy (TDF + ETV group) in chronic hepatitis B (CHB) patients with ..
  50. Fasano M, Maggi P, Leone A, Volpe A, Fiore J, Angarano G, et al. Long-term efficacy and safety of switching from lamivudine+adefovir to tenofovir disoproxil fumarate in virologically suppressed patients. Dig Liver Dis. 2017;49:530-534 pubmed publisher
    Tenofovir disoproxil fumarate (TDF) is recommended as first-line monotherapy for nucleos(t)ide (NA)-naïve chronic hepatitis B (CHB) patients and as a second-line rescue therapy for NA-experienced patients with a previous treatment ..
  51. Martínez Ramírez I, Del Castillo Falconi V, Mitre Aguilar I, Amador Molina A, Carrillo García A, Langley E, et al. SOX2 as a New Regulator of HPV16 Transcription. Viruses. 2017;9: pubmed publisher
    ..We identified sex determining region Y (SRY)-box 2 (SOX2) response elements present in HPV16-LCR...
  52. Kozielewicz D, Halota W, Wietlicka Piszcz M. Tenofovir rescue therapy in chronic hepatitis B patients who failed previous nucleoside analogue treatment. Hepatol Int. 2016;10:302-9 pubmed publisher
    Tenofovir (TDF) is considered as the first line therapy for chronic hepatitis B. This study presents the results of TDF monotherapy in patients who failed previous nucleoside analogue treatment...
  53. Pitrone M, Pizzolanti G, Tomasello L, Coppola A, Morini L, Pantuso G, et al. NANOG Plays a Hierarchical Role in the Transcription Network Regulating the Pluripotency and Plasticity of Adipose Tissue-Derived Stem Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..the different expression of the embryonic stem cell markers NANOG (homeobox protein NANOG), SOX2 (SRY (sex determining region Y)-box 2) and OCT4 (octamer-binding transcription factor 4) and to evaluate if there ..
  54. Yao G, Zhang Z, Wang J. Beta transmutations in apatites with ferric iron as an electron acceptor - implication for nuclear waste form development. Phys Chem Chem Phys. 2017;19:25487-25497 pubmed publisher
    ..with Cs+ and Fe3+ substitutions undergoing the Cs ? Ba transmutation, and of Ca3SrY4Fe2(SiO4)6F2 with Sr2+ and Fe3+ ..
  55. Stephan A, Kovacs E, Phillips A, Schelling J, Ulrich S, Grill E. Barriers and facilitators for the management of vertigo: a qualitative study with primary care providers. Implement Sci. 2018;13:25 pubmed publisher
    ..motivation for behaviour change (COM-B) using questions based on constructs from the Theoretical Domains Framework (TDF) and the Consolidated Framework for Implementation Research (CFIR)...
  56. Ho B, Greenlaw K, Al Tuwaijri A, Moussette S, Martinez F, Giorgio E, et al. X chromosome dosage and presence of SRY shape sex-specific differences in DNA methylation at an autosomal region in human cells. Biol Sex Differ. 2018;9:10 pubmed publisher
    ..Our data show that the presence of the sex determining region Y (SRY) was associated with lower methylation levels, whereas higher X chromosome dosage in the absence of SRY led to an ..
  57. Song L, Liu D, He J, Wang X, Dai Z, Zhao Y, et al. SOX1 inhibits breast cancer cell growth and invasion through suppressing the Wnt/?-catenin signaling pathway. APMIS. 2016;124:547-55 pubmed publisher
    ..Several studies have demonstrated that SRY (sex-determining region Y)-box (SOX) family genes serve as either tumor suppressor genes or oncogenes by regulating ..
  58. Rui X, Xu Y, Jiang X, Guo C, Jiang J. SOX15 regulates proliferation and migration of endometrial cancer cells. Biosci Rep. 2017;37: pubmed publisher
    The study aimed to investigate the effects of Sry-like high mobility group box 15 (SOX15) on proliferation and migration of endometrial cancer (EC) cells...
  59. Ko H, Lam T, Ng H, Toh J, Wang L, Ren E. Identification of Slug and SOX7 as transcriptional repressors binding to the hepatitis B virus core promoter. J Hepatol. 2017;: pubmed publisher
    ..Slug (SNAI2) and SRY-related HMG box 7 (SOX7) transcriptional repressors were identified and shown to bind specifically to the HBVCP by ..
  60. Prévostel C, Blache P. The dose-dependent effect of SOX9 and its incidence in colorectal cancer. Eur J Cancer. 2017;86:150-157 pubmed publisher
    A member of the Sry-related HMG-box family of transcription factors (SOX9) is a transcription factor that belongs to the superfamily of High Mobility Group (HMG) domain transcription factors...
  61. Lee J, Lee S, Song S, Kwak I, Lee S. Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea. Korean J Intern Med. 2017;: pubmed publisher
    Little is known about tenofovir disoproxil fumarate (TDF)-induced nephrotoxicity in human immunodeficiency virus (HIV)-infected patients in Korea...
  62. Rosenfeld C. Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?. Front Neurosci. 2017;11:632 pubmed publisher
    ..Testes development in mammals requires a Y chromosome and testis determining gene SRY (in humans)/Sry (all other therian mammals), although there are notable exceptions...
  63. Choe J, Ko J, Choe B, Kim J, Kang B, Lee K, et al. Antiviral Efficacy of Tenofovir Monotherapy in Children with Nucleos(t)ide-naive Chronic Hepatitis B. J Korean Med Sci. 2018;33:e11 pubmed publisher
    The purpose was to compare the efficacy between tenofovir disoproxil fumarate (TDF) and lamivudine (LMV) in children with nucleos(t)ide-naive chronic hepatitis B (CHB) infection...
  64. Mayer A, Lahr G, Swaab D, Pilgrim C, Reisert I. The Y-chromosomal genes SRY and ZFY are transcribed in adult human brain. Neurogenetics. 1998;1:281-8 pubmed
    ..Here we show that two Y-chromosomal genes involved in sex determination of the gonad, SRY and ZFY, are transcribed in hypothalamus, and frontal and temporal cortex of the adult male human brain...
  65. Ortenberg J, Oddoux C, Craver R, McElreavey K, Salas Cortes L, Guillen Navarro E, et al. SRY gene expression in the ovotestes of XX true hermaphrodites. J Urol. 2002;167:1828-31 pubmed
    The pathogenesis of 46 XX true hermaphroditism is uncertain and the role of the SRY gene in ovotestis development has not been thoroughly evaluated. We ascertained the presence of the SRY gene and SRY protein in the ovotestis...
  66. Sánchez Moreno I, Canto P, Munguía P, de León M, Cisneros B, Vilchis F, et al. DNA binding activity studies and computational approach of mutant SRY in patients with 46, XY complete pure gonadal dysgenesis. Mol Cell Endocrinol. 2009;299:212-8 pubmed publisher
    Mutations of SRY are the cause of 46,XY complete pure gonadal dysgenesis (PGD) in 10-15% of patients...
  67. Sládková V, Dammer O, Kratochvíl B. Solid Forms of Tenofovir Disoproxil Fumarate, Their Mutual Conversion, and Stabilization of Form I in Formulation. J Pharm Sci. 2016;105:3136-3142 pubmed publisher
    Tenofovir disoproxil fumarate (TDF, form I) is an orally delivered pharmaceutical salt used for the treatment of HIV and chronic hepatitis, which acts as an inhibitor of nucleotide reverse transcriptase...
  68. Arnold A. A general theory of sexual differentiation. J Neurosci Res. 2017;95:291-300 pubmed publisher
    ..inequality leads to male-specific effects of the Y chromosome, including expression of the testis-determining gene Sry that causes differentiation of testes. Thus, Sry sets up lifelong sex differences in effects of gonadal hormones...
  69. Crayton E, Fahey M, Ashworth M, Besser S, Weinman J, Wright A. Psychological Determinants of Medication Adherence in Stroke Survivors: a Systematic Review of Observational Studies. Ann Behav Med. 2017;51:833-845 pubmed publisher
    ..To date, no systematic review has mapped identified determinants into the Theoretical Domains Framework (TDF) in order to establish a more complete understanding of medication adherence...
  70. Shaheen A, AlMattooq M, Yazdanfar S, Burak K, Swain M, Congly S, et al. Tenofovir disoproxil fumarate significantly decreases serum lipoprotein levels compared with entecavir nucleos(t)ide analogue therapy in chronic hepatitis B carriers. Aliment Pharmacol Ther. 2017;46:599-604 pubmed publisher
    Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are first-line treatments for chronic hepatitis B (CHB)...
  71. DAVIS A, Brogan A, Goodwin B, Nocea G, Lozano V. Short-term cost and efficiency analysis of raltegravir versus atazanavir/ritonavir or darunavir/ritonavir for treatment-naive adults with HIV-1 infection in Spain. HIV Clin Trials. 2017;18:214-222 pubmed publisher
    ..ATV/r) and darunavir/ritonavir (DRV/r), when used in combination with emtricitabine/tenofovir DF (FTC/TDF), in a 96-week composite endpoint combining virologic efficacy and tolerability for treatment-naive adults with HIV-..
  72. Kuroki S, Tachibana M. Epigenetic regulation of mammalian sex determination. Mol Cell Endocrinol. 2018;468:31-38 pubmed publisher
    ..Mammalian sex determination is triggered by activation of the mammalian sex-determining gene, Sry, in a spatially and temporally accurate manner...
  73. Davis R. Localisation of male determining factors in man: a thorough review of structural anomalies of the Y chromosome. J Med Genet. 1981;18:161-95 pubmed
    ..Recently proposed arguments in its favour are examined. Some evidence also indicates the presence of a fertility factor on the non-fluorescent segment of the long arm. Relevant information on the H-Y antigen is discussed. ..
  74. Haqq C, King C, Ukiyama E, Falsafi S, Haqq T, Donahoe P, et al. Molecular basis of mammalian sexual determination: activation of Müllerian inhibiting substance gene expression by SRY. Science. 1994;266:1494-500 pubmed
    The pathway of male sexual development in mammals is initiated by SRY, a gene on the short arm of the Y chromosome...
  75. Caglayan A, Demiryilmaz F, Kendirci M, Ozyazgan I, Akalin H, Bittmann S. Mixed gonadal dysgenesis with 45,X/46,X,idic(Y)/46,XY,idic(Y) karyotype. Genet Couns. 2009;20:173-9 pubmed
    ..We suggest that study of cytogenetic and molecular mosaicism involving sex chromosomes may help to further unravel the mysterious process in mixed gonadal dysgeneic patients...
  76. Tjwa E, Zoutendijk R, van Oord G, Boeijen L, Reijnders J, van Campenhout M, et al. Similar frequencies, phenotype and activation status of intrahepatic NK cells in chronic HBV patients after long-term treatment with tenofovir disoproxil fumarate (TDF). Antiviral Res. 2016;132:70-5 pubmed publisher
    ..frequencies, phenotype, and activation status of intrahepatic NK cells of CHB patients on prolonged treatment with TDF. Fine needle aspiration biopsies were collected from 11 chronic HBV patients at baseline, and at 12, 24, and 48 ..
  77. Cheung C, Lai W, Shuter J. Zidovudine- versus Tenofovir-Based Antiretroviral Therapy for the Initial Treatment of HIV Infection in the Ethnic Minority Region of Liangshan Prefecture, Sichuan Province, China. J Int Assoc Provid AIDS Care. 2017;16:189-193 pubmed publisher
    Tenofovir (TDF)-based highly active antiretroviral therapy (HAART), as recommended by the World Health Organization guidelines for HIV-naive patients, has been limited in resource-constrained settings...
  78. Tun Yhong W, Chinpaisal C, Pamonsinlapatham P, Kaewkitichai S. Tenofovir Disoproxil Fumarate Is a New Substrate of ATP-Binding Cassette Subfamily C Member 11. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    Tenofovir disoproxil fumarate (TDF), a nucleotide reverse transcriptase inhibitor, after conversion to tenofovir (TFV), is mainly eliminated by glomerular filtration and active tubular secretion...
  79. Debono D, Taylor N, Lipworth W, Greenfield D, Travaglia J, Black D, et al. Applying the Theoretical Domains Framework to identify barriers and targeted interventions to enhance nurses' use of electronic medication management systems in two Australian hospitals. Implement Sci. 2017;12:42 pubmed publisher
    ..This study uses the Theoretical Domains Framework (TDF) to identify barriers and targeted interventions to enhance nurses' appropriate use of EMMS in two Australian ..
  80. Chen J, Zhao S, Liu X, Huang Z, Huang Y. Comparison of the Efficacy of Tenofovir Versus Tenofovir plus Entecavir in the Treatment of Chronic Hepatitis B in Patients With Poor Efficacy of Entecavir: A Systematic Review and Meta-analysis. Clin Ther. 2017;39:1870-1880 pubmed publisher
    This study aimed to compare the efficacy between tenofovir disoproxil fumarate (TDF) and TDF plus entecavir (ETV) combination therapy in patients with chronic hepatitis B (CHB) with a poor response to ETV...
  81. Solas C, Bregigeon S, Faucher Zaegel O, Quaranta S, Obry Roguet V, Tamalet C, et al. Ledipasvir and Tenofovir drug interaction in HIV-HCV co-infected patients: Impact on Tenofovir Ctrough and Renal Safety. Br J Clin Pharmacol. 2017;: pubmed publisher
    ..and estimated glomerular renal function (eGFR) in HIV-HCV co-infected patients receiving a tenofovir(TDF)-based antiretroviral regimen and treated with ledipasvir/sofosbuvir...
  82. Nathan N, Elton B, Babic M, McCarthy N, Sutherland R, Presseau J, et al. Barriers and facilitators to the implementation of physical activity policies in schools: A systematic review. Prev Med. 2018;107:45-53 pubmed publisher
    ..screened texts, extracted and coded data from identified articles using the Theoretical Domains Framework (TDF). Of the 10,346 articles identified, 17 studies met the inclusion criteria (8 quantitative, 9 qualitative)...
  83. Oh G, Kim J, Park Y. Development of stabilized tenofovir disoproxil tablet: degradation profile, stabilization, and bioequivalence in beagle dogs. Drug Dev Ind Pharm. 2018;44:757-766 pubmed publisher
    ..To develop a stabilized TD tablet bioequivalent to the commercial TD fumarate (TDF, Viread®) tablet, TD free base was prepared and its degradation profile and stability were investigated...
  84. Zenteno J, Lopez M, Vera C, Mendez J, Kofman Alfaro S. Two SRY-negative XX male brothers without genital ambiguity. Hum Genet. 1997;100:606-10 pubmed
    ..Molecular studies revealed that both patients were negative for several Y sequences, including SRY. A review of familial cases disclosed that this is the first family where a complete male phenotype was observed in ..
  85. Agate R, Choe M, Arnold A. Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches. Mol Biol Evol. 2004;21:384-96 pubmed publisher
    ..These differences between CHD1Z and CHD1W suggest that the two proteins may have diverged in their function...
  86. Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, et al. Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis. Proc Natl Acad Sci U S A. 2016;113:7840-5 pubmed publisher
    ..genes, such as collagen type (Col)1a1 and Col3a1, and chondrogenic differentiation-related genes, such as SRY-box (Sox)5, Sox6, and Sox9 Our results demonstrate that Mkx has a dual role, including accelerating tendon ..
  87. Masuyama K, Shojo H, Nakanishi H, Inokuchi S, Adachi N. Sex Determination from Fragmented and Degenerated DNA by Amplified Product-Length Polymorphism Bidirectional SNP Analysis of Amelogenin and SRY Genes. PLoS ONE. 2017;12:e0169348 pubmed publisher
    ..We could correctly identify the sex of 11 out of 14 individuals. These results show that our method is reliable for the sex determination of highly degenerated samples. ..
  88. Wassner C, Maiti S, Kodroff K, Cohen H. Iatrogenic Adrenal Insufficiency Secondary to Combination Therapy with Elvitegravir/Cobicistat/Tenofovir Disoproxil Fumarate/Emtricitabine and Interlaminar Triamcinolone Injection in an AIDS Patient. J Int Assoc Provid AIDS Care. 2017;16:535-539 pubmed publisher
    ..Stribild (elvitegravir 150 mg/cobicistat 150 mg/tenofovir disoproxil fumarate 300 mg/emtricitabine 200 mg [EVG/c/TDF/FTC])...
  89. Kouamé G, Boyd A, Moh R, Badjé A, Gabillard D, Ouattara E, et al. Higher mortality despite early ART in HIV and hepatitis B virus coinfected patients with high HBV replication. Clin Infect Dis. 2017;: pubmed publisher
    ..Tenofovir+emtricitabine/lamivudine (TDF/XTC)-based antiretroviral therapy (ART), which suppresses HIV and HBV replication, has the potential for decreasing ..
  90. Shi H, Li X, Zhu J, Lin C, Zhang Y. [Clinical effect of entecavir versus tenofovir in treatment of HBeAg-positive chronic hepatitis B patients with a high viral load: a comparative analysis]. Zhonghua Gan Zang Bing Za Zhi. 2017;25:721-725 pubmed publisher
    ..To investigate the clinical effect and safety of entecavir (ETV) versus tenofovir disoproxil fumarate (TDF) in the treatment of previously untreated HBeAg-positive chronic hepatitis B (CHB) patients with a high viral load...
  91. Nishijima T, Kawasaki Y, Mutoh Y, Tomonari K, Tsukada K, Kikuchi Y, et al. Prevalence and factors associated with chronic kidney disease and end-stage renal disease in HIV-1-infected Asian patients in Tokyo. Sci Rep. 2017;7:14565 pubmed publisher
    ..Older age, heavier body weight, diabetes mellitus, hypertension, and longer duration of ART, but not duration of TDF exposure, were associated with CKD...
  92. Adana M, Akang E, Peter A, Jegede A, Naidu E, Tiloke C, et al. Naringenin attenuates highly active antiretroviral therapy-induced sperm DNA fragmentations and testicular toxicity in Sprague-Dawley rats. Andrology. 2017;: pubmed publisher
    ..into six groups viz - Control; H: 30 mg/kg of highly active antiretroviral therapy (EFV, 600 mg + FTC, 200 mg + TDF, 300 mg); N40: Naringenin, 40 mg/kg; N80: Naringenin, 80 mg/kg; HN40: highly active antiretroviral therapy + ..