Gene Symbol: SRSF9
Description: serine and arginine rich splicing factor 9
Alias: SFRS9, SRp30c, serine/arginine-rich splicing factor 9, SR splicing factor 9, pre-mRNA-splicing factor SRp30C, splicing factor, arginine/serine-rich 9
Species: human
Products:     SRSF9

Top Publications

  1. Raffetseder U, Frye B, Rauen T, Jurchott K, Royer H, Jansen P, et al. Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection. J Biol Chem. 2003;278:18241-8 pubmed
    ..Here, we identify the arginine/serine-rich SRp30c protein as an interacting protein of YB-1 by performing a two-hybrid screen against a human mesangial cell cDNA ..
  2. Xu Q, Leung D, Kisich K. Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils. J Biol Chem. 2003;278:27112-8 pubmed
    ..The predominant alternative splicing factor in neutrophils is SRp30c, which is one of several highly conserved serine-arginine-rich (SR) proteins that are involved in both ..
  3. Yoshino H, Enokida H, Chiyomaru T, Tatarano S, Hidaka H, Yamasaki T, et al. Tumor suppressive microRNA-1 mediated novel apoptosis pathways through direct inhibition of splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) in bladder cancer. Biochem Biophys Res Commun. 2012;417:588-93 pubmed publisher
    ..In this study, we focused on splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) on the basis of our previous genome-wide gene expression analysis using miR-1-transfected BC cell lines because ..
  4. Shepard P, Hertel K. The SR protein family. Genome Biol. 2009;10:242 pubmed publisher
    ..These activities point up the importance of SR proteins during the regulation of mRNA metabolism. ..
  5. Screaton G, Caceres J, Mayeda A, Bell M, Plebanski M, Jackson D, et al. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J. 1995;14:4336-49 pubmed
    ..We have cloned a cDNA encoding a novel human SR protein designated SRp30c, which has an unusually short RS domain...
  6. Biswas S, Haleyurgirisetty M, Ragupathy V, Wang X, Lee S, Hewlett I, et al. Differentially expressed host long intergenic noncoding RNA and mRNA in HIV-1 and HIV-2 infection. Sci Rep. 2018;8:2546 pubmed publisher
    ..In HIV-2 infected MDMs, CUL 2, SFRS9, and RBBP4 genes were differentially expressed...
  7. Buoso E, Galasso M, Ronfani M, Serafini M, Lanni C, Corsini E, et al. Role of spliceosome proteins in the regulation of glucocorticoid receptor isoforms by cortisol and dehydroepiandrosterone. Pharmacol Res. 2017;120:180-187 pubmed publisher
    ..SR)-Rich Splicing Factors (SRSF) regulating GR splicing, specifically SRSF9 and SRSF3 also known as SRp30c and SRp20 respectively...
  8. Elliott D, Bourgeois C, Klink A, Stevenin J, Cooke H. A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection. Proc Natl Acad Sci U S A. 2000;97:5717-22 pubmed
    ..Our results suggest that RBM protein is an evolutionarily conserved mammalian splicing regulator which operates as a germ cell-specific cofactor for more ubiquitously expressed pre-mRNA splicing activators. ..
  9. Somberg M, Li X, Johansson C, Orru B, Chang R, Rush M, et al. Serine/arginine-rich protein 30c activates human papillomavirus type 16 L1 mRNA expression via a bimodal mechanism. J Gen Virol. 2011;92:2411-21 pubmed publisher
    ..These splice sites are suppressed in mitotic cells. This study showed that serine/arginine-rich protein 30c (SRp30c), also named SFRS9, activated both SD3632 and SA5639 and induced production of L1 mRNA...

More Information


  1. Petersen Mahrt S, Estmer C, Ohrmalm C, Matthews D, Russell W, Akusjarvi G. The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation. EMBO J. 1999;18:1014-24 pubmed
    ..Here we present evidence that p32 interacts with ASF/SF2 and SRp30c, another member of the SR protein family...
  2. Manley J, Krainer A. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). Genes Dev. 2010;24:1073-4 pubmed publisher
  3. Fingert J, Alward W, Wang K, Yorio T, Clark A. Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders. Mol Vis. 2010;16:596-601 pubmed
    ..Iowa Ophthalmology Clinics after IRB approved consent. Genotyping of DNA samples for 48 SNPs in SFRS3, SFRS5, SFRS9, FKBP4, FKBP5, and NR3C1 was done at GeneSeek using a mass spectroscopy based system...
  4. Wang J, Gao Q, Wang Y, Lafyatis R, Stamm S, Andreadis A. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. J Neurochem. 2004;88:1078-90 pubmed
    ..Lastly, we identified the domains of regulators SWAP and hnRNPG, which are required for regulation of exon 10 splicing. ..
  5. Wang Y, Wang J, Gao L, Lafyatis R, Stamm S, Andreadis A. Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1. J Biol Chem. 2005;280:14230-9 pubmed
    ..this study, we investigated three regulators of exon 2 and 10 splicing: serine/arginine-rich (SR) proteins SRp55, SRp30c, and htra2beta1. The first two inhibit both exons; htra2beta1 inhibits exon 2 but activates exon 10...
  6. Guan Y, Jiang L, Ma L, Sun X, Yu D, Liu J, et al. Expression of glucocorticoid receptor isoforms and associations with serine/arginine-rich protein 30c and 40 in patients with systemic lupus erythematosus. Clin Exp Rheumatol. 2015;33:225-33 pubmed
    ..Transcript levels of GRα, GRβ, GRγ, GR-P, SRp30c and SRp40 in peripheral blood mononuclear cells (PBMCs) were determined by real-time PCR...
  7. Venables J, Elliott D, Makarova O, Makarov E, Cooke H, Eperon I. RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing. Hum Mol Genet. 2000;9:685-94 pubmed
    ..The RNA-binding domain of RBM affected 5' splice site selection. We conclude that the hnRNP G family of proteins is involved in pre-mRNA splicing and infer that RBM may be involved in Tra2beta-dependent splicing in spermatocytes. ..
  8. Denegri M, Chiodi I, Corioni M, Cobianchi F, Riva S, Biamonti G. Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors. Mol Biol Cell. 2001;12:3502-14 pubmed
    ..With the use of the 580-725 region as bait in a two-hybrid screening, we have selected SRp30c and 9G8, two members of the SR family of splicing factors...
  9. Nayler O, Stratling W, Bourquin J, Stagljar I, Lindemann L, Jasper H, et al. SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements. Nucleic Acids Res. 1998;26:3542-9 pubmed
  10. Yuan Y, Li D, Sun H. PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem. 1998;273:20347-53 pubmed
    ..In addition, we have found that PIR1 interacted with splicing factors 9G8 and SRp30C, possibly through an RNA intermediate during a yeast two-hybrid screen...
  11. Jain A, Wordinger R, Yorio T, Clark A. Spliceosome protein (SRp) regulation of glucocorticoid receptor isoforms and glucocorticoid response in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2012;53:857-66 pubmed publisher
    ..mRNA splicing is mediated by spliceosomes, which include serine-arginine rich proteins (SRps). The purpose of this study was to determine whether specific SRps regulate levels of these isoforms and thereby GC response in TM cells...
  12. Zhu J, Gong J, Goodman O, Cartegni L, Nanus D, Shen R. Bombesin attenuates pre-mRNA splicing of glucocorticoid receptor by regulating the expression of serine-arginine protein p30c (SRp30c) in prostate cancer cells. Biochim Biophys Acta. 2007;1773:1087-94 pubmed
    ..We found that suppression of SRp30c expression by siRNA specifically antagonized bombesin's effect on glucocorticoid-mediated inhibition of PC cells, ..
  13. Kondo S, Yamamoto N, Murakami T, Okumura M, Mayeda A, Imaizumi K. Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA. Genes Cells. 2004;9:121-30 pubmed
    ..b>SRp30c also enhanced the splicing of tau exon 10...
  14. Simard M, Chabot B. SRp30c is a repressor of 3' splice site utilization. Mol Cell Biol. 2002;22:4001-10 pubmed
    ..This protein corresponds to SRp30c. Consistent with a role for SRp30c in the activity of CE9, recombinant SRp30c interacts specifically with CE9 and ..
  15. Young P, DiDonato C, Hu D, Kothary R, Androphy E, Lorson C. SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1. Hum Mol Genet. 2002;11:577-87 pubmed
    ..We now demonstrate that a second splicing factor, SRp30c, can stimulate SMN exon 7-inclusion and that this activity required the same AG-rich enhancer as hTra2 beta 1...
  16. Cloutier P, Toutant J, Shkreta L, Goekjian S, Revil T, Chabot B. Antagonistic effects of the SRp30c protein and cryptic 5' splice sites on the alternative splicing of the apoptotic regulator Bcl-x. J Biol Chem. 2008;283:21315-24 pubmed publisher
    ..b>SRp30c binds to these elements and can shift splicing to the 5' splice site of Bcl-x(L) in an ML2/AM2-dependent manner in ..
  17. Paradis C, Cloutier P, Shkreta L, Toutant J, Klarskov K, Chabot B. hnRNP I/PTB can antagonize the splicing repressor activity of SRp30c. RNA. 2007;13:1287-300 pubmed
    ..We have shown previously that the 5' portion of the 38-nucleotide-long CE9 element is bound by SRp30c, and that this interaction is important for repression in vitro...
  18. Stoss O, Schwaiger F, Cooper T, Stamm S. Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. J Biol Chem. 1999;274:10951-62 pubmed
    We report on the molecular cloning of a novel human cDNA by its interaction with the splicing factor SRp30c in a yeast two-hybrid screen...
  19. Bressan G, Moraes E, Manfiolli A, Kuniyoshi T, Passos D, Gomes M, et al. Arginine methylation analysis of the splicing-associated SR protein SFRS9/SRP30C. Cell Mol Biol Lett. 2009;14:657-69 pubmed publisher
    The human SFRS9/SRp30c belongs to the SR family of splicing regulators. Despite evidence that members of this protein family may be targeted by arginine methylation, this has yet to be experimentally addressed...
  20. Bressan G, Quaresma A, Moraes E, Manfiolli A, Passos D, Gomes M, et al. Functional association of human Ki-1/57 with pre-mRNA splicing events. FEBS J. 2009;276:3770-83 pubmed publisher
    ..assays, we verified the association of Ki-1/57 with the endogenous splicing proteins hnRNPQ and SFRS9 in HeLa cell extracts...
  21. Fu Y, Huang B, Shi Z, Han J, Wang Y, Huangfu J, et al. SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing ?-catenin biosynthesis. EMBO Mol Med. 2013;5:737-50 pubmed publisher
    ..Overexpression of SRSF1 and SRSF9 promote ?-catenin accumulation via the recruitment of ?-catenin mRNA and by enhancing its translation in an mTOR-..
  22. Stoss O, Olbrich M, Hartmann A, Konig H, Memmott J, Andreadis A, et al. The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites. J Biol Chem. 2001;276:8665-73 pubmed
    ..various proteins involved in the regulation of alternative splicing, among them the serine/arginine-rich protein SRp30c, the splicing-associated factor YT521-B and the scaffold attachment factor B...