Gene Symbol: SRSF6
Description: serine and arginine rich splicing factor 6
Alias: B52, HEL-S-91, SFRS6, SRP55, serine/arginine-rich splicing factor 6, SR splicing factor 6, epididymis secretory protein Li 91, pre-mRNA-splicing factor SRP55, splicing factor, arginine/serine-rich, 55 kDa
Species: human
Products:     SRSF6

Top Publications

  1. Zahler A, Lane W, Stolk J, Roth M. SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev. 1992;6:837-47 pubmed
    ..In four of the family members a repeated protein sequence that encompasses an RNA recognition motif was observed. We discuss the potential role of this highly conserved, functionally related set of proteins in pre-mRNA splicing. ..
  2. Screaton G, Caceres J, Mayeda A, Bell M, Plebanski M, Jackson D, et al. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J. 1995;14:4336-49 pubmed
    ..We also cloned cDNAs encoding the human homologues of Drosophila SRp55/B52 and rat SRp40/HRS...
  3. Gui J, Lane W, Fu X. A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature. 1994;369:678-82 pubmed
  4. Liu H, Zhang M, Krainer A. Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev. 1998;12:1998-2012 pubmed
    ..we have identified three novel classes of exonic splicing enhancers (ESEs) recognized by human SF2/ASF, SRp40, and SRp55, respectively. These ESEs are functional in splicing and are highly specific...
  5. Le Hir H, Moore M, Maquat L. Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions. Genes Dev. 2000;14:1098-108 pubmed
    ..Such proteins could influence downstream metabolic events in vivo such as mRNA transport, translation, and nonsense-mediated decay. ..
  6. Pecce V, Sponziello M, Damante G, Rosignolo F, Durante C, Lamartina L, et al. A synonymous RET substitution enhances the oncogenic effect of an in-cis missense mutation by increasing constitutive splicing efficiency. PLoS Genet. 2018;14:e1007678 pubmed publisher
    ..Cys630 = variant created new exonic splicing enhancer motifs that enhanced SRp55 recruitment to the mutant allele, leading to more efficient maturation of its pre-mRNA and an increased abundance ..
  7. Wan Z, Li D, Li X, Zhu Y, Gao T, Li W, et al. B52 promotes alternative splicing of Dscam in Chinese mitten crab, Eriocheir sinensis. Fish Shellfish Immunol. 2019;87:460-469 pubmed publisher
    b>B52 is a member of the classical serine/arginine (SR)-rich proteins, which are phylogenetically conserved and play significant roles in mRNA maturation, including alternative splicing...
  8. Iborra S, Hirschfeld M, Jaeger M, zur Hausen A, Braicu I, Sehouli J, et al. Alterations in expression pattern of splicing factors in epithelial ovarian cancer and its clinical impact. Int J Gynecol Cancer. 2013;23:990-6 pubmed publisher
    ..However, in our patient cohort, no induction was seen for the other investigated splicing factors SRp55, SRp40, and hTra2α...
  9. Fernando C, Audibert A, Simon F, Tazi J, Juge F. A role for the serine/arginine-rich (SR) protein B52/SRSF6 in cell growth and myc expression in Drosophila. Genetics. 2015;199:1201-11 pubmed publisher
    ..Here, we analyzed phenotypes induced by overexpression of the SR protein B52 during Drosophila development and identified several proteins that can rescue these phenotypes...

More Information


  1. Kawashima Y, Noguchi Y, Takase H, Takahashi M, Horie S. Bilateral hearing impairment as the initial symptom of sympathetic ophthalmia. Am J Otolaryngol. 2015;36:606-10 pubmed publisher
    ..Patient 1 carried HLA-DR4, HLA-DR15, HLA-A33, HLA-A24, HLA-B44 and HLA-B52, and patient 2 carried HLA-DR4...
  2. Origuchi T, Fukui S, Umeda M, Nishino A, Nakashima Y, Koga T, et al. The Severity of Takayasu Arteritis Is Associated with the HLA-B52 Allele in Japanese Patients. Tohoku J Exp Med. 2016;239:67-72 pubmed publisher
    ..Among the 35 patients, 25 patients were examined for the existence of the HLA-B52 allele that has been reported to influence TA susceptibility. Seventeen patients (68...
  3. Mayer S, Hirschfeld M, Jaeger M, Pies S, Iborra S, Erbes T, et al. RON alternative splicing regulation in primary ovarian cancer. Oncol Rep. 2015;34:423-30 pubmed publisher
    ..Significant splicing factor interactions (e.g. SRp55/SRp75: p<0.001) were observed in tumor samples with alternative RON splicing...
  4. Van Rijn A, Claas E, von dem Borne P, Kroes A, de Vries J. Rhinovirus viremia in adult patients with high viral load in bronchoalveolar lavages. J Clin Virol. 2017;96:105-109 pubmed publisher
    ..Genotyping demonstrated rhinovirus A01, A24, B52 and B92 in these four immunocompromised patients...
  5. Watters K, Inankur B, Gardiner J, Warrick J, Sherer N, Yin J, et al. Differential Disruption of Nucleocytoplasmic Trafficking Pathways by Rhinovirus 2A Proteases. J Virol. 2017;91: pubmed publisher
    ..Live-cell imaging of single cells expressing recombinant RV 2Apro (A16, A45, B04, B14, B52, C02, and C15) showed disruption of each pathway with measurably different efficiencies and reaction rates...
  6. Zhang Z, Cao W, Edery I. The SR protein B52/SRp55 regulates splicing of the period thermosensitive intron and mid-day siesta in Drosophila. Sci Rep. 2018;8:1872 pubmed publisher
    ..Using a Drosophila cell culture assay we show that B52/SRp55 increases dmpi8 splicing efficiency, whereas other SR proteins have little to no effect...
  7. Finley J. Reactivation of latently infected HIV-1 viral reservoirs and correction of aberrant alternative splicing in the LMNA gene via AMPK activation: Common mechanism of action linking HIV-1 latency and Hutchinson-Gilford progeria syndrome. Med Hypotheses. 2015;85:320-32 pubmed publisher
    ..Recent evidence has shown that inhibition of the splicing factors ASF/SF2 (or SRSF1) and SRp55 (or SRSF6) leads to a reduction or an increase in progerin at both the mRNA and protein levels, respectively, thus ..
  8. Gálvez E, Carrillo Castro K, Zárate L, Güiza L, Pieper D, García Bonilla E, et al. Draft Genome Sequence of Bacillus licheniformis CG-B52, a Highly Virulent Bacterium of Pacific White Shrimp (Litopenaeus vannamei), Isolated from a Colombian Caribbean Aquaculture Outbreak. Genome Announc. 2016;4: pubmed publisher
    Bacillus licheniformis strain CG-B52 was isolated as the etiological agent producing a self-limited outbreak of high mortalities in commercial Litopenaeus vannamei culture ponds on the Colombian Caribbean coast in 2005...
  9. Liu B, Bossing T. Single neuron transcriptomics identify SRSF/SR protein B52 as a regulator of axon growth and Choline acetyltransferase splicing. Sci Rep. 2016;6:34952 pubmed publisher
    ..4). One transcript encodes the RNA splicing factor B52. Loss of B52 increases growth of axon branches...
  10. Ohigashi H, Tamura N, Ebana Y, Harigai M, Maejima Y, Ashikaga T, et al. Effects of immunosuppressive and biological agents on refractory Takayasu arteritis patients unresponsive to glucocorticoid treatment. J Cardiol. 2017;69:774-778 pubmed publisher
    ..were and were not able to achieve and maintain remission with immunosuppressive agents was the presence of the HLA-B52 allele (p<0.0001). Biological agents were administered to 6 patients refractory to immunosuppressive agents...
  11. Lu S, Yin X. Overexpression of Dyrk1A regulates cardiac troponin T splicing in cells and mice. Biochem Biophys Res Commun. 2016;473:993-998 pubmed publisher
    ..cTnT isoforms containing exon 5 are expressed in the fetal and neonatal heart but not in the mature heart. SRp55 is an essential splicing factor involved in cTnT exon 5 splicing and it is phosphorylated by Dyrk1A (dual ..
  12. Lemaire R, Winne A, Sarkissian M, Lafyatis R. SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation. Eur J Immunol. 1999;29:823-37 pubmed
    ..Like SF2 and SWAP, the SR proteins SC35, SRp40 and SRp75, but not SRp55 also induced CD45 exon 4 skipping. In contrast, antisense inhibition of SRp55 induced exon 4 skipping...
  13. Whitaker E, Filippov V, Filippova M, Guerrero Juarez C, Duerksen Hughes P. Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells. Cytokine. 2011;56:272-81 pubmed publisher
    ..Additionally, we found that the ratio of isoform expression can be modified by the splice factor SRp55. This regulation suggests that alternative splicing of mda-7/IL-24 is under tight control in the cell, and can be ..
  14. Ramchatesingh J, Zahler A, Neugebauer K, Roth M, Cooper T. A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer. Mol Cell Biol. 1995;15:4898-907 pubmed
    ..Analyses involving UV cross-linking and immunoprecipitation indicated that only four (SRp30a, SRp40, SRp55, and SRp75) of six essential splicing factors known as SR proteins bind to the active enhancer RNA...
  15. Juan Mateu J, Alvelos M, Turatsinze J, Villate O, Lizárraga Mollinedo E, Grieco F, et al. SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival. Diabetes. 2018;67:423-436 pubmed publisher
    ..Here we show that SRp55, a splicing factor regulated by the diabetes susceptibility gene GLIS3, has a major role in maintaining the ..
  16. Wang H, Lin W, Dyck J, Yeakley J, Songyang Z, Cantley L, et al. SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. J Cell Biol. 1998;140:737-50 pubmed
    ..Together, our studies suggest that different SRPK family members may be uniquely regulated and targeted, thereby contributing to splicing regulation in different tissues, during development, or in response to signaling. ..
  17. Swanson C, Sherer N, Malim M. SRp40 and SRp55 promote the translation of unspliced human immunodeficiency virus type 1 RNA. J Virol. 2010;84:6748-59 pubmed publisher
    ..Here, we report that specific SR proteins, particularly SRp40 and SRp55, promote human immunodeficiency virus type 1 (HIV-1) Gag translation from unspliced (intron-containing) viral RNA...
  18. Fossey S, Mychaleckyj J, Pendleton J, Snyder J, Bensen J, Hirakawa S, et al. A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. Genomics. 2001;76:45-57 pubmed
    ..The combination of the BAC transcript map, YAC-to-BAC scaffold, and reference Human Genome Project sequence provides a powerful integrated resource for future genomic analysis of this region. ..
  19. Nagel R, Lancaster A, Zahler A. Specific binding of an exonic splicing enhancer by the pre-mRNA splicing factor SRp55. RNA. 1998;4:11-23 pubmed
    ..In this report, we show that purified SR protein family member SRp55 by itself binds a 30-nt ESE-containing exon, the alternatively spliced exon 5 of avian cardiac troponin T...
  20. Barnard D, Patton J. Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. Mol Cell Biol. 2000;20:3049-57 pubmed vitro and in vivo activation of specific splice sites by a subset of SR proteins, including ASF/SF2, SC35, and SRp55. In contrast, p86 activates splicing in the presence of SRp20...
  21. Lai F, Jiang C, Farrelly M, Zhang X, Hersey P. Evidence for upregulation of Bim and the splicing factor SRp55 in melanoma cells from patients treated with selective BRAF inhibitors. Melanoma Res. 2012;22:244-51 pubmed publisher
    ..BH3 protein Bim and its splice forms, downregulation of Mcl-1, and upregulation of the splicing factor SRp55 as reported in previous in-vitro studies...
  22. Yin X, Jin N, Gu J, Shi J, Zhou J, Gong C, et al. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion. J Biol Chem. 2012;287:30497-506 pubmed publisher
    ..In the present study, we found that splicing factor SRp55 (serine/arginine-rich protein 55) promoted Tau exon 10 inclusion...
  23. Jensen M, Wilkinson J, Krainer A. Splicing factor SRSF6 promotes hyperplasia of sensitized skin. Nat Struct Mol Biol. 2014;21:189-97 pubmed publisher
    ..Here, we identify the splicing factor SRSF6 as a regulator of wound healing and tissue homeostasis in skin...
  24. Kong J, Sun W, Li C, Wan L, Wang S, Wu Y, et al. Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6. Cancer Lett. 2016;380:476-84 pubmed publisher
    ..An alternative splicing factor SRSF6 was identified to directly interact with LINC01133, and SRSF6 promoted EMT and metastasis in CRC cells independent ..
  25. Tranell A, Tingsborg S, Fenyo E, Schwartz S. Inhibition of splicing by serine-arginine rich protein 55 (SRp55) causes the appearance of partially spliced HIV-1 mRNAs in the cytoplasm. Virus Res. 2011;157:82-91 pubmed publisher
    We have previously shown that SRp55 inhibits splicing from HIV-1 exon 3, thereby generating partially spliced mRNAs encoding HIV-1 vpr...
  26. Cohen Eliav M, Golan Gerstl R, Siegfried Z, Andersen C, Thorsen K, Ørntoft T, et al. The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers. J Pathol. 2013;229:630-9 pubmed publisher
    ..of several splicing factors in colon and lung tumours, and found that the gene encoding for the splicing factor SRSF6 is amplified and over-expressed in these cancers...
  27. Nayler O, Stratling W, Bourquin J, Stagljar I, Lindemann L, Jasper H, et al. SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements. Nucleic Acids Res. 1998;26:3542-9 pubmed
  28. Paillard F. A novel soluble chimera for the treatment of familial hypercholesterolemia. Hum Gene Ther. 1999;10:1093-4 pubmed
  29. Tran Q, Coleman T, Roesser J. Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer. Biochim Biophys Acta. 2003;1625:141-52 pubmed
    ..The 55-kDa protein is SRp55, a member of the SR family of phosphoproteins...
  30. Tran Q, Roesser J. SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing. Biochemistry. 2003;42:951-7 pubmed
    ..The calcitonin-specific fourth exon contains an exonic splice enhancer (ESE) that binds SRp55. We define the RNA binding site of SRp55 in the ESE and demonstrate that base changes that decrease the level of ..
  31. Lai M, Lin R, Tarn W. Differential effects of hyperphosphorylation on splicing factor SRp55. Biochem J. 2003;371:937-45 pubmed
    ..DRB), an inhibitor of RNA polymerase II-dependent transcription, specifically induced hyperphosphorylation of SRp55 but not that of any other SR proteins tested...
  32. Tardos J, Eisenreich A, Deikus G, Bechhofer D, Chandradas S, Zafar U, et al. SR proteins ASF/SF2 and SRp55 participate in tissue factor biosynthesis in human monocytic cells. J Thromb Haemost. 2008;6:877-84 pubmed publisher
    ..TF mRNA, revealed putative binding motifs termed exonic splicing enhancers (ESE) for the SR proteins ASF/SF2 and SRp55, which were found to be abundantly expressed in monocytic cell lines THP-1 and SC, as well as monocyte-enriched ..
  33. Filippov V, Schmidt E, Filippova M, Duerksen Hughes P. Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes. Gene. 2008;420:34-41 pubmed publisher
    ..b>SRp55 is one of the most ubiquitous splicing factors and one that can be up-regulated by DNA damage in the absence of ..
  34. Shepard P, Hertel K. The SR protein family. Genome Biol. 2009;10:242 pubmed publisher
    ..These activities point up the importance of SR proteins during the regulation of mRNA metabolism. ..
  35. Hara H, Takeda T, Yamamoto N, Furuya K, Hirose K, Kamiya T, et al. Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS. FEBS J. 2013;280:3313-27 pubmed publisher
    ..analysis using the Bim mini-gene revealed that predicted binding sites of the SR protein SRSF6, also known as SRp55, are located in the intronic region adjacent to exon 4...
  36. Lareau L, Inada M, Green R, Wengrod J, Brenner S. Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements. Nature. 2007;446:926-9 pubmed
    ..We find that unproductive splicing associated with conserved regions has arisen independently in different SR genes, suggesting that splicing factors may readily acquire this form of regulation. ..
  37. Wang J, Gao Q, Wang Y, Lafyatis R, Stamm S, Andreadis A. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. J Neurochem. 2004;88:1078-90 pubmed
    ..Lastly, we identified the domains of regulators SWAP and hnRNPG, which are required for regulation of exon 10 splicing. ..
  38. Fernández Nogales M, Santos Galindo M, Hernández I, Cabrera J, Lucas J. Faulty splicing and cytoskeleton abnormalities in Huntington's disease. Brain Pathol. 2016;26:772-778 pubmed publisher
    ..Here we review the reported alteration of the CAG-repeat associated splicing factor SRSF6 in brains of HD patients and mouse models and how this correlates with altered splicing of, at least, two ..
  39. Pind M, Watson P. SR protein expression and CD44 splicing pattern in human breast tumours. Breast Cancer Res Treat. 2003;79:75-82 pubmed
    ..We conclude that while SR proteins may be important and necessary factors in mRNA splicing, other factors are also necessary to influence the regulation of alternatively spliced isoforms of CD44. ..
  40. Manley J, Krainer A. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). Genes Dev. 2010;24:1073-4 pubmed publisher
  41. Wang Q, Sun Y, Liu J, Zhang D. Rheinheimera marina sp. nov., isolated from a deep-sea seamount. Int J Syst Evol Microbiol. 2017;: pubmed publisher
    ..and had the highest 16S rRNA gene sequence similarity with the type strain Rheinheimera tangshanensis JA3-B52T (96.8?%)...
  42. Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman B. Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. Mol Cell. 2000;6:307-16 pubmed
    ..PGC-1 can alter the processing of an mRNA, but only when it is loaded onto the promoter of the gene. These data demonstrate the coordinated regulation of RNA transcription and processing through PGC-1. ..
  43. Erkelenz S, Hillebrand F, Widera M, Theiss S, Fayyaz A, Degrandi D, et al. Balanced splicing at the Tat-specific HIV-1 3'ss A3 is critical for HIV-1 replication. Retrovirology. 2015;12:29 pubmed publisher
    ..RNA in vitro binding assays revealed SRSF2 and SRSF6 as candidate splicing factors acting through ESE tat and ESE2 for 3'ss A3 activation...
  44. Tranell A, Fenyo E, Schwartz S. Serine- and arginine-rich proteins 55 and 75 (SRp55 and SRp75) induce production of HIV-1 vpr mRNA by inhibiting the 5'-splice site of exon 3. J Biol Chem. 2010;285:31537-47 pubmed publisher
    ..Here we show that serine- and arginine-rich proteins 55 and 75 (SRp55 and SRp75) inhibit splicing from the 5'-splice site of exon 3 thereby causing an accumulation of the partially ..