SRSF5

Summary

Gene Symbol: SRSF5
Description: serine and arginine rich splicing factor 5
Alias: HRS, SFRS5, SRP40, serine/arginine-rich splicing factor 5, SR splicing factor 5, delayed-early protein HRS, pre-mRNA-splicing factor SRP40, splicing factor, arginine/serine-rich 5
Species: human
Products:     SRSF5

Top Publications

  1. Zahler A, Lane W, Stolk J, Roth M. SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev. 1992;6:837-47 pubmed
    ..In four of the family members a repeated protein sequence that encompasses an RNA recognition motif was observed. We discuss the potential role of this highly conserved, functionally related set of proteins in pre-mRNA splicing. ..
  2. Gui J, Lane W, Fu X. A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature. 1994;369:678-82 pubmed
  3. Richards B, Whittle S, Buchbinder R. Muscle relaxants for pain management in rheumatoid arthritis. Cochrane Database Syst Rev. 2012;1:CD008922 pubmed publisher
    ..the included trials failed to find evidence of a beneficial effect of muscle relaxants over placebo, alone (at 24 hrs, 1 or 2 weeks) or in addition to non-steroidal anti-inflammatory drugs (NSAIDs) (at 24 hrs), on pain intensity, ..
  4. Xu B, Kong X, Xu R, Song Y, Liu L, Zhou Z, et al. Homocysteine and all-cause mortality in hypertensive adults without pre-existing cardiovascular conditions: Effect modification by MTHFR C677T polymorphism. Medicine (Baltimore). 2017;96:e5862 pubmed publisher
    ..Hazard ratios (HRs) and 95% confidence intervals were estimated by Cox proportional-hazard regression models, adjusting for age, sex, ..
  5. Wen L, Javed T, Yimlamai D, Mukherjee A, Xiao X, Husain S. Transient High Pressure in Pancreatic Ducts Promotes Inflammation and Alters Tight Junctions via Calcineurin Signaling in Mice. Gastroenterology. 2018;155:1250-1263.e5 pubmed publisher
    ..These processes require calcineurin signaling. Calcineurin inhibitors might be used to prevent acute pancreatitis that results from obstruction. ..
  6. Liang S, Ma H, Zhong Z, Dhar D, Liu X, Xu J, et al. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 2019;156:1156-1172.e6 pubmed publisher
    ..Strategies to block NOX1 or these cytokines might be developed to slow hepatocellular carcinoma progression. ..
  7. Skaaby T. The relationship of vitamin D status to risk of cardiovascular disease and mortality. Dan Med J. 2015;62: pubmed
    ..by respiratory diseases, digestive diseases, and endocrine, nutritional and metabolic diseases with hazard ratios (HRs) 0.26 (ptrend = 0.0042), 0.28 (ptrend = 0.0040), and 0.21 (ptrend = 0...
  8. Friedman D, Hilden P, Moskowitz C, Suzuki M, Boulad F, Kernan N, et al. Cardiovascular Risk Factors in Survivors of Childhood Hematopoietic Cell Transplantation Treated with Total Body Irradiation: A Longitudinal Analysis. Biol Blood Marrow Transplant. 2017;23:475-482 pubmed publisher
    ..Cox regression models were used to estimate hazard ratios (HRs) for factors associated with each CVRF...
  9. Weiner D, Park M, Tighiouart H, Joseph A, Carpenter M, Goyal N, et al. Albuminuria and Allograft Failure, Cardiovascular Disease Events, and All-Cause Death in Stable Kidney Transplant Recipients: A Cohort Analysis of the FAVORIT Trial. Am J Kidney Dis. 2019;73:51-61 pubmed publisher
    ..ACR of 30 to 299 and ≥300mg/g relative to ACR < 10mg/g were independently associated with graft failure (HRs of 3.40 [95% CI, 2.19-5.30] and 9.96 [95% CI, 6.35-15.62], respectively), CVD events (HRs of 1.25 [95% CI, 0.96-1...

More Information

Publications161 found, 100 shown here

  1. Emilsson L, Wijmenga C, Murray J, Ludvigsson J. Autoimmune Disease in First-Degree Relatives and Spouses of Individuals With Celiac Disease. Clin Gastroenterol Hepatol. 2015;13:1271-1277.e2 pubmed publisher
    ..We used Cox regression analysis to calculate hazard ratios (HRs) for nonceliac autoimmune disease (Crohn's disease, type 1 diabetes mellitus, hypothyroidism, hyperthyroidism, ..
  2. Wändell P, Carlsson A, Li X, Gasevic D, Arnlov J, Holzmann M, et al. Atrial fibrillation in immigrant groups: a cohort study of all adults 45 years of age and older in Sweden. Eur J Epidemiol. 2017;32:785-796 pubmed publisher
    ..immigrant groups, using Swedish-born as referents, was assessed by Cox regression, expressed in hazard ratios (HRs) and 95% confidence intervals (CI)...
  3. Yasen A, Herrera R, Rosbe K, Lien K, Tugizov S. Release of HIV-1 sequestered in the vesicles of oral and genital mucosal epithelial cells by epithelial-lymphocyte interaction. PLoS Pathog. 2017;13:e1006247 pubmed publisher
    ..siRNA)-mediated silencing of its critical protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) expression reduced viral sequestration in epithelial cells and its transmission from epithelial cells to ..
  4. Bardia A, Sood A, Mahmood F, Orhurhu V, Mueller A, Montealegre Gallegos M, et al. Combined Epidural-General Anesthesia vs General Anesthesia Alone for Elective Abdominal Aortic Aneurysm Repair. JAMA Surg. 2016;151:1116-1123 pubmed publisher
    ..82) complications. Combined EA-GA was associated with improved survival and significantly lower HRs and ORs for mortality and morbidity in patients undergoing elective AAA repair...
  5. Płachetka Bożek A, Kafel A, Augustyniak M. Reproduction and development of Spodoptera exigua from cadmium and control strains under differentiated cadmium stress. Ecotoxicol Environ Saf. 2018;166:138-145 pubmed publisher
    ..indirectly responsible for the telomere length) was higher in the individuals from the cadmium strain 24 hrs after eclosion...
  6. Getnet D, Gautam A, Kumar R, Hoke A, Cheema A, Rossetti F, et al. Poisoning with Soman, an Organophosphorus Nerve Agent, Alters Fecal Bacterial Biota and Urine Metabolites: a Case for Novel Signatures for Asymptomatic Nerve Agent Exposure. Appl Environ Microbiol. 2018;84: pubmed publisher
  7. Ding N, Wang X, Tucker K, Weisskopf M, Sparrow D, Hu H, et al. Dietary patterns, bone lead and incident coronary heart disease among middle-aged to elderly men. Environ Res. 2019;168:222-229 pubmed publisher
    ..Cox proportional hazard models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for incident CHD...
  8. Nair N. Dose-dependent short-term study of di-n-butyl phthalate on the testicular antioxidant system of Wistar rats. Environ Sci Pollut Res Int. 2015;22:2196-204 pubmed publisher
    ..DBP at doses of 500, 1,000 and 1,500 mg/kg b.wt. (doses below LD50) was given orally for 7 days. After 24 hrs from the last dose, the animals were killed under ether anesthesia...
  9. Budoff M, Mayrhofer T, Ferencik M, Bittner D, Lee K, Lu M, et al. Prognostic Value of Coronary Artery Calcium in the PROMISE Study (Prospective Multicenter Imaging Study for Evaluation of Chest Pain). Circulation. 2017;136:1993-2005 pubmed publisher
    ..1 months. Cox regression models were used to calculate hazard ratios (HRs) and C statistics to determine predictive and discriminatory values...
  10. Sheikh M, Poustchi H, Pourshams A, Etemadi A, Islami F, Khoshnia M, et al. Individual and Combined Effects of Environmental Risk Factors for Esophageal Cancer Based on Results From the Golestan Cohort Study. Gastroenterology. 2019;156:1416-1427 pubmed publisher
    ..Proportional hazards regression models were used to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for the association between different exposures and ESCC...
  11. Svane M, Bojsen Møller K, Martinussen C, Dirksen C, Madsen J, Reitelseder S, et al. Postprandial Nutrient Handling and Gastrointestinal Hormone Secretion After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy. Gastroenterology. 2019;156:1627-1641.e1 pubmed publisher
    ..ClinicalTrials.gov ID NCT03046186. ..
  12. Lazo M, Nwankwo C, Daya N, Thomas D, Mehta S, Juraschek S, et al. Confluence of Epidemics of Hepatitis C, Diabetes, Obesity, and Chronic Kidney Disease in the United States Population. Clin Gastroenterol Hepatol. 2017;15:1957-1964.e7 pubmed publisher
    ..Cox proportional hazards regression models to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of all-cause, cardiovascular, and cancer mortality according to chronic ..
  13. Bao X, Mao A, Fang Y, Fan Y, Wang F, Ma J, et al. Simvastatin Decreases Hyperoxic Oxygen-Induced Acute Lung Injury by Upregulating eNOS. Am J Physiol Lung Cell Mol Physiol. 2017;:ajplung.00520.2016 pubmed publisher
    ..23 MPa (= 2.3 atmosphere absolute (ATA)) hyperoxia ( 95% O2) for 6 hrs. Mice were either given simvastatin (20 mg/kg/day) in saline or a saline vehicle for 3 days before oxygen exposure...
  14. Li Q, Shen Y, Ahmad A, Shen Y, Zhang Y, Xu P, et al. Mesencephalic Astrocyte-Derived Neurotrophic Factor Prevents Traumatic Brain Injury in Rats by Inhibiting Inflammatory Activation and Protecting the Blood-Brain Barrier. World Neurosurg. 2018;117:e117-e129 pubmed publisher
  15. Gencer B, Auer R, de Rekeneire N, Butler J, Kalogeropoulos A, Bauer D, et al. Association between resistin levels and cardiovascular disease events in older adults: The health, aging and body composition study. Atherosclerosis. 2016;245:181-6 pubmed publisher
    ..2-59.8, P for trend < 0.001). In the multivariate models adjusted for clinical variables, HRs for the highest vs. lowest quartile of resistin was 1.52 (95% CI 1.20-1.93, P < 0...
  16. Paliwal D, Joshi P, Panda S. Hepatitis E Virus (HEV) egress: Role of BST2 (Tetherin) and interferon induced long non- coding RNA (lncRNA) BISPR. PLoS ONE. 2017;12:e0187334 pubmed publisher
    ..Our transcriptome analysis in Hepatitis E virus (HEV) replicon transfected Huh7 cells at 24 and 72 hrs indicated that at 24hrs, both LncBISPR and BST2, expressed by a bidirectional promoter were highly upregulated ..
  17. Hruskova Z, Pippias M, Stel V, Abad Díez J, Benítez Sánchez M, Caskey F, et al. Characteristics and Outcomes of Patients With Systemic Sclerosis (Scleroderma) Requiring Renal Replacement Therapy in Europe: Results From the ERA-EDTA Registry. Am J Kidney Dis. 2019;73:184-193 pubmed publisher
    ..mortality from day 91 on RRT was higher among patients with scleroderma than observed in both control groups (HRs of 1.25 [95% CI, 1.05-1.48] and 2.00 [95% CI, 1.69-2.39])...
  18. Duong M, Islam S, Rangarajan S, Leong D, Kurmi O, Teo K, et al. Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV1 (PURE): an international, community-based cohort study. Lancet Glob Health. 2019;7:e613-e623 pubmed publisher
    ..Fully adjusted hazard ratios (HRs) were calculated by multilevel Cox regression...
  19. Busby J, Mills K, Zhang S, Liberante F, Cardwell C. Selective serotonin reuptake inhibitor use and breast cancer survival: a population-based cohort study. Breast Cancer Res. 2018;20:4 pubmed publisher
    ..We used Cox regression models to calculate hazard ratios (HRs) comparing mortality between post-diagnostic SSRI users and non-users (using time-dependant covariates), after ..
  20. de Oliveira C, Khatua B, Bag A, El Kurdi B, Patel K, Mishra V, et al. Multimodal Transgastric Local Pancreatic Hypothermia Reduces Severity of Acute Pancreatitis in Rats and Increases Survival. Gastroenterology. 2019;156:735-747.e10 pubmed publisher
    ..In rats with AP, transgastric local pancreatic hypothermia decreases pancreatic necrosis, apoptosis, inflammation, and markers of pancreatitis severity and increases survival. ..
  21. Maruta Y, Hasegawa T, Yamakoshi E, Nishiwaki H, Koiwa F, Imai E, et al. Association between serum Na-Cl level and renal function decline in chronic kidney disease: results from the chronic kidney disease Japan cohort (CKD-JAC) study. Clin Exp Nephrol. 2019;23:215-222 pubmed publisher
    ..Using Cox regression analysis, hazard ratios (HRs) were estimated after adjusting for the following covariates: age, sex, diabetes mellitus, diabetic nephropathy, ..
  22. Mikkelsen U, Dideriksen K, Andersen M, Boesen A, Malmgaard Clausen N, Sørensen I, et al. Preserved skeletal muscle protein anabolic response to acute exercise and protein intake in well-treated rheumatoid arthritis patients. Arthritis Res Ther. 2015;17:271 pubmed publisher
    ..5 g/kg lean body mass) alone (PROT, 3 hrs) and in combination with knee-extensor exercise (EX) with one leg (8 × 10 reps at 70 % of 1RM; PROT + EX, 3 hrs)..
  23. Gomathi D, Ravikumar G, Kalaiselvi M, Devaki K, Uma C. Efficacy of Evolvulus alsinoides (L.) L. on insulin and antioxidants activity in pancreas of streptozotocin induced diabetic rats. J Diabetes Metab Disord. 2013;12:39 pubmed publisher
    ..histopathological analysis, the pancreatic tissues of all experimental groups were fixed with 10% formalin for 24 hrs then the samples were stained with haemotoxylin-eosin for the microscopic observation...
  24. Duan K, Yu W, Lin Z, Tan S, Bai X, Gao T, et al. Endotoxemia-induced muscle wasting is associated with the change of hypothalamic neuropeptides in rats. Neuropeptides. 2014;48:379-86 pubmed publisher
    ..Twelve, 24 and 48 hrs after injection, skeletal muscle and hypothalamus tissues were harvested...
  25. Chou S, Tsai M, Huang J, Chang Y, Shih C. The Dual Role of an ESCRT-0 Component HGS in HBV Transcription and Naked Capsid Secretion. PLoS Pathog. 2015;11:e1005123 pubmed publisher
    ..We identified a number of ESCRT factors required for HBV replication, and focused our study here on HGS (HRS, hepatocyte growth factor-regulated tyrosine kinase substrate) in the ESCRT-0 complex...
  26. Matsushita K, Ballew S, Coresh J, Arima H, Arnlov J, Cirillo M, et al. Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data. Lancet Diabetes Endocrinol. 2017;5:718-728 pubmed publisher
    ..Compared with an eGFR of 95 mL/min per 1·73 m2, adjusted hazard ratios (HRs) for incident study-specific peripheral artery disease was 1·22 (95% CI 1·14-1·30) at an eGFR of 45 mL/min per 1..
  27. Wang S, Andrews C, Herman W, Gardner T, Stein J. Incidence and Risk Factors for Developing Diabetic Retinopathy among Youths with Type 1 or Type 2 Diabetes throughout the United States. Ophthalmology. 2017;124:424-430 pubmed publisher
    ..Hazard ratios (HRs) with 95% confidence intervals (CIs) for developing DR...
  28. Piano S, Tonon M, Angeli P. Management of ascites and hepatorenal syndrome. Hepatol Int. 2018;12:122-134 pubmed publisher
    ..Hepatorenal syndrome (HRS) is the most life-threatening type of AKI in patients with cirrhosis...
  29. Chen Y, Wu F, Saito E, Lin Y, Song M, Luu H, et al. Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium. Diabetologia. 2017;60:1022-1032 pubmed publisher
    ..b>HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from ..
  30. Wei Q, Chen Y, Cao B, Ou R, Zhang L, Hou Y, et al. Blood hemoglobin A1c levels and amyotrophic lateral sclerosis survival. Mol Neurodegener. 2017;12:69 pubmed publisher
    ..Multivariate Cox proportional hazards regression model was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of ALS mortality across the exposures...
  31. Liu H, Hua N, Xie K, Zhao T, Yu Y. Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and overactivation of poly (ADP-ribose) polymerase-1 in retinal ischemia-reperfusion injury. Mol Med Rep. 2015;12:2495-502 pubmed publisher
    ..The present study was conducted to demonstrate whether hydrogen-rich saline (HRS) has a neuroprotective effect on retinal ischemia reperfusion (RIR) injury through inhibition of PARP-1 activation...
  32. Watson J, Bhattacharyya B, Vaden J, Wilson J, Icyuz M, Howard A, et al. Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS. PLoS Genet. 2015;11:e1005290 pubmed publisher
    ..tn) is a single nucleotide substitution in hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs/Hrs), a component of the endosomal sorting complex required for transport (ESCRT)...
  33. Pinault L, Weichenthal S, Crouse D, Brauer M, Erickson A, Donkelaar A, et al. Associations between fine particulate matter and mortality in the 2001 Canadian Census Health and Environment Cohort. Environ Res. 2017;159:406-415 pubmed publisher
    ..We used Cox survival models to determine hazard ratios (HRs) for cause-specific mortality...
  34. Bütof R, Hofheinz F, Zöphel K, Stadelmann T, Schmollack J, Jentsch C, et al. Prognostic Value of Pretherapeutic Tumor-to-Blood Standardized Uptake Ratio in Patients with Esophageal Carcinoma. J Nucl Med. 2015;56:1150-6 pubmed publisher
    ..The highest hazard ratios (HRs) were found for scan-time-corrected maximum SUR (HR = 3.9) and mean SUR (HR = 4.4)...
  35. von Stumm M, Teufelsbauer H, Reichenspurner H, Debus E. Two Decades of Endovascular Repair of Popliteal Artery Aneurysm--A Meta-analysis. Eur J Vasc Endovasc Surg. 2015;50:351-9 pubmed publisher
    ..Random effect models were employed to estimate odds ratios (ORs), mean differences, and hazard ratios (HRs)...
  36. Stadler N, Shang A, Bosch F, Briggs A, Goede V, Berthier A, et al. A Systematic Review and Network Meta-Analysis to Evaluate the Comparative Efficacy of Interventions for Unfit Patients with Chronic Lymphocytic Leukemia. Adv Ther. 2016;33:1814-1830 pubmed
    ..R-Clb), ofatumumab + chlorambucil (O-Clb), fludarabine and chlorambucil (median hazard ratios [HRs] 0.43, 0.33, 0.20, and 0...
  37. Elmedany S, Naga S, Elsharkawy R, Mahrous R, Elnaggar A. Novel urinary biomarkers and the early detection of acute kidney injury after open cardiac surgeries. J Crit Care. 2017;40:171-177 pubmed publisher
    ..Urine sediment score(USS) 1 and 2 were higher in the AKI group than in the non-AKI group 2 hrs after CPB and till the end of the 2nd day with area under the curve (AUC) average of (0.865)...
  38. Arima R, Marttila M, Hautakoski A, Arffman M, Sund R, Ilanne Parikka P, et al. Antidiabetic medication, statins and the risk of endometrioid endometrial cancer in patients with type 2 diabetes. Gynecol Oncol. 2017;146:636-641 pubmed publisher
    ..Poisson regression was utilized to estimate the hazard ratios (HRs) with 95% confidence intervals (95% CIs) of the endometrioid EC in relation to the use of metformin, other oral ADM,..
  39. Bell E, Agarwal S, Cushman M, Heckbert S, Lutsey P, Folsom A. Orthostatic Hypotension and Risk of Venous Thromboembolism in 2 Cohort Studies. Am J Hypertens. 2016;29:634-40 pubmed publisher
    ..We calculated adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs) for incident VTE in relation to OH status...
  40. Bodnar L, Parks W, Perkins K, Pugh S, Platt R, Feghali M, et al. Maternal prepregnancy obesity and cause-specific stillbirth. Am J Clin Nutr. 2015;102:858-64 pubmed publisher
    ..7, 10.6, 13.9, and 17.3 per 1000 live-born and stillborn infants, respectively. Adjusted stillbirth HRs (95% CIs) were 1.4 (1.1, 1.8) for overweight, 1.8 (1.3, 2.4) for obese, and 2.0 (1.5, 2...
  41. Fretts A, Mozaffarian D, Siscovick D, King I, McKnight B, Psaty B, et al. Associations of Plasma Phospholipid SFAs with Total and Cause-Specific Mortality in Older Adults Differ According to SFA Chain Length. J Nutr. 2016;146:298-305 pubmed publisher
    ..phospholipid SFAs 18:0, 22:0, and 24:0 were associated with a lower risk of total mortality [multivariable-adjusted HRs (95% CIs)] for the top compared with the bottom quintile: 0.85 (0.75, 0.95) for 18:0; 0.85 (0.75, 0...
  42. Cepoiu Martin M, Tam Tham H, Patten S, Maxwell C, Hogan D. Predictors of long-term care placement in persons with dementia: a systematic review and meta-analysis. Int J Geriatr Psychiatry. 2016;31:1151-1171 pubmed publisher
    ..We performed meta-analyses with hazard ratios (HRs) of various predictors using random effects models and stratified the HRs with several study variables...
  43. de Baaij J, Kompatscher A, Viering D, Bos C, Bindels R, Hoenderop J. P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis. PLoS ONE. 2016;11:e0156803 pubmed publisher
    ..Differences in serum concentration and 24-hrs urine excretion of Na+, K+, Mg2+ and Ca2+ were not detected between P2x6+/+, P2x6+/- and P2x6-/- mice...
  44. Liu J, Wang T, Sung L, Kao P, Yang T, Hao W, et al. Influenza vaccination reduces hemorrhagic stroke risk in patients with atrial fibrillation: A population-based cohort study. Int J Cardiol. 2017;232:315-323 pubmed publisher
    ..A time-dependent Cox proportional hazard model was used to calculate the hazard ratios (HRs) for hemorrhagic stroke in vaccinated and unvaccinated patients with AF...
  45. Costa Paiva E, Whelan N, Waits D, Santos S, Schrago C, Halanych K. Discovery and evolution of novel hemerythrin genes in annelid worms. BMC Evol Biol. 2017;17:85 pubmed publisher
    ..Four subgroups of Hrs have been documented, including: circulating Hr (cHr), myohemerythrin (myoHr), ovohemerythrin (ovoHr), and ..
  46. Brenner H, Jansen L, Saum K, Holleczek B, Schöttker B. Vitamin D Supplementation Trials Aimed at Reducing Mortality Have Much Higher Power When Focusing on People with Low Serum 25-Hydroxyvitamin D Concentrations. J Nutr. 2017;147:1325-1333 pubmed publisher
    ..4 y. We estimated adjusted HRs of mortality from all causes, cardiovascular disease, and cancer for defined increases in serum 25(OH)D by Cox ..
  47. Hong K, Bhutta M, Liu X, Shin Y. Classification of somatosensory cortex activities using fNIRS. Behav Brain Res. 2017;333:225-234 pubmed publisher
    ..a lab-made multi-channel functional near-infrared spectroscopy (fNIRS) to discriminate the hemodynamic responses (HRs) of four different tactile stimulations (handshake, ball grasp, poking, and cold temperature) applied to the right ..
  48. Mitsuhashi K, Hashimoto Y, Hamaguchi M, Obora A, Kojima T, Fukuda T, et al. Impact of fatty liver disease and metabolic syndrome on incident type 2 diabetes; a population based cohort study. Endocr J. 2017;64:1105-1114 pubmed publisher
    ..33 (95% CI 1.85-2.94, p<0.001) in MetS with fatty liver. In addition, adjusted HRs for incident diabetes compared with MetS without fatty liver were 1.39 (95% CI 1.07-1.80, p=0...
  49. Sparano J, Zhao F, Martino S, Ligibel J, Perez E, Saphner T, et al. Long-Term Follow-Up of the E1199 Phase III Trial Evaluating the Role of Taxane and Schedule in Operable Breast Cancer. J Clin Oncol. 2015;33:2353-60 pubmed publisher
    ..The primary end point was disease-free survival (DFS). Results are expressed as hazard ratios (HRs) from Cox proportional hazards models. All P values are two sided...
  50. Talaei M, Koh W, Yuan J, Pan A. The association between dairy product intake and cardiovascular disease mortality in Chinese adults. Eur J Nutr. 2017;56:2343-2352 pubmed publisher
    ..Cox proportional hazard models were used to calculate hazard ratios (HRs) and corresponding 95 % confidence intervals (95 % CIs) with adjustment for potential confounders, including ..
  51. Lee D, Park S, Lim S, Lee M, Giovannucci E, Kim J, et al. Resting heart rate as a prognostic factor for mortality in patients with breast cancer. Breast Cancer Res Treat. 2016;159:375-84 pubmed publisher
    ..RHR was measured at baseline and the mean follow-up time for all patients was 5.0 ± 2.5 years. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated using Cox regression models...
  52. Kalscheur M, Donateo P, Wenzke K, Aste M, Oddone D, Solano A, et al. Long-Term Outcome of Patients with Bifascicular Block and Unexplained Syncope Following Cardiac Pacing. Pacing Clin Electrophysiol. 2016;39:1126-1131 pubmed publisher
    According to the ACC/AHA/HRS guidelines, cardiac pacing is reasonable in patients with bifascicular block (BF-B) and syncope when other causes have been excluded...
  53. Karlsson P, Cole B, Price K, Gelber R, Coates A, Goldhirsch A, et al. Timing of Radiation Therapy and Chemotherapy After Breast-Conserving Surgery for Node-Positive Breast Cancer: Long-Term Results From International Breast Cancer Study Group Trials VI and VII. Int J Radiat Oncol Biol Phys. 2016;96:273-279 pubmed publisher
    ..3% in the group allocated 3 months initial CT (HR 1.11; 95% CI 0.82-1.51). Corresponding HRs for local failures were 0.94 (95% CI 0.61-1.46) in trial VI and 1.51 (95% CI 0.77-2.97) in trial VII...
  54. Ren J, Wu H, Wang W, Hu G, Gu B, Zhang M, et al. C-Met as a potential novel prognostic marker in squamous cell carcinoma and adenocarcinoma of esophagus: evidence from a meta-analysis. Panminerva Med. 2017;59:97-106 pubmed publisher
    ..fixed-effects or random-effects model according to heterogeneity was applied to calculate the pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS), disease-free survival (DFS) and disease-specific ..
  55. Markwardt D, Holdt L, Steib C, Benesic A, Bendtsen F, Bernardi M, et al. Plasma cystatin C is a predictor of renal dysfunction, acute-on-chronic liver failure, and mortality in patients with acutely decompensated liver cirrhosis. Hepatology. 2017;66:1232-1241 pubmed publisher
    ..gelatinase-associated lipocalin (NGAL) can predict development of renal dysfunction (RD), hepatorenal syndrome (HRS), ACLF, and mortality...
  56. Seo J, Choi J, Kim H, Kim J, Yang J, Cuhadar C, et al. Wafer-scale reliable switching memory based on 2-dimensional layered organic-inorganic halide perovskite. Nanoscale. 2017;9:15278-15285 pubmed publisher
    ..Quasi 2D compositions with n = 2 and 3 are also compared. Transition from a high resistance state (HRS) to a low resistance state (LRS) occurs at 0...
  57. Bernard O, Jeny F, Uzunhan Y, Dondi E, Terfous R, Label R, et al. Mesenchymal stem cells reduce hypoxia-induced apoptosis in alveolar epithelial cells by modulating HIF and ROS hypoxic signalings. Am J Physiol Lung Cell Mol Physiol. 2017;:ajplung.00153.2017 pubmed publisher
    ..Exposure of rat primary AECs to hypoxia (1.5% O2 for 24 hrs) resulted in Hypoxia-Inducible Factor (HIF)-1? protein stabilization, partly dependent on reactive oxygen species (..
  58. Rossides M, Kullberg S, Askling J, Eklund A, Grunewald J, Arkema E. Sarcoidosis mortality in Sweden: a population-based cohort study. Eur Respir J. 2018;51: pubmed publisher
    ..Adjusted mortality rates, rate differences and hazard ratios (HRs) were estimated, stratifying by age, sex and treatment status.The mortality rate was 11...
  59. Phipps A, Shi Q, Zemla T, Dotan E, Gill S, Goldberg R, et al. Physical Activity and Outcomes in Patients with Stage III Colon Cancer: A Correlative Analysis of Phase III Trial NCCTG N0147 (Alliance). Cancer Epidemiol Biomarkers Prev. 2018;27:696-703 pubmed publisher
    ..Using multivariable Cox models, we calculated HRs for associations of aspects of physical activity with disease-free (DFS) and overall survival (OS)...
  60. Maida V, Ennis M, Kesthely C. Clinical parameters associated with pressure ulcer healing in patients with advanced illness. J Pain Symptom Manage. 2014;47:1035-42 pubmed publisher
    ..4% of Stage II pressure ulcers achieved complete healing. Univariable analyses showed hazard ratios (HRs) for complete healing in favor of higher levels of PPS scores (HR 1.82-5.99, P<0...
  61. Zhou R, Wei C, Liu J, Luo Y, Tang W. The prognostic value of p53 expression for patients with cervical cancer: a meta analysis. Eur J Obstet Gynecol Reprod Biol. 2015;195:210-3 pubmed publisher
    ..The final meta-analysis contained 11 published studies including 1105 patients. Combined HRs suggested that p53 overexpression has an unfavorable impact on overall survival(OS) [HR=1...
  62. Vale C, Burdett S, Rydzewska L, Albiges L, Clarke N, Fisher D, et al. Addition of docetaxel or bisphosphonates to standard of care in men with localised or metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data. Lancet Oncol. 2016;17:243-256 pubmed publisher
    ..For each trial, we extracted hazard ratios (HRs) of the effects of docetaxel or bisphosphonates on survival (time from randomisation until death from any cause) ..
  63. Koh G, Derscheid R, Fuller K, Valentine R, Leow S, Reed L, et al. Circulating adiponectin concentrations are increased by dietary resistant starch and correlate with serum 25-hydroxycholecalciferol concentrations and kidney function in Zucker diabetic fatty rats. Nutr Res. 2016;36:311-319 pubmed publisher
    ..rats (n = 5/group) were fed either an AIN-93G control diet (DC) or AIN-93G diet containing either 10% RS or 20% RS (HRS) for 6 weeks...
  64. Wannamethee S, Welsh P, Lennon L, Papacosta O, Whincup P, Sattar N. Copeptin and the risk of incident stroke, CHD and cardiovascular mortality in older men with and without diabetes: The British Regional Heart Study. Diabetologia. 2016;59:1904-12 pubmed publisher
    ..Compared with those in the lowest tertile of copeptin, men in the top tertile had adjusted relative HRs for stroke and CVD death of 2.34 (95% CI 1.04, 5.27) and 2.21 (1.12, 4.36), respectively...
  65. Sanders A, Akinkugbe A, Fillingim R, Ohrbach R, Greenspan J, Maixner W, et al. Causal Mediation in the Development of Painful Temporomandibular Disorder. J Pain. 2017;18:428-436 pubmed publisher
    ..analysis was conducted using a weighted Cox proportional hazards regression model that estimated hazard ratios (HRs) and 95% confidence limits (CL) of first-onset TMD...
  66. Weichenthal S, Bai L, Hatzopoulou M, Van Ryswyk K, Kwong J, Jerrett M, et al. Long-term exposure to ambient ultrafine particles and respiratory disease incidence in in Toronto, Canada: a cohort study. Environ Health. 2017;16:64 pubmed publisher
    ..Random-effect Cox proportional hazard models were used to estimate hazard ratios (HRs) describing the association between ambient UFPs and respiratory disease incidence adjusting for ambient fine ..
  67. Douros A, Yin H, Yu O, Filion K, Azoulay L, Suissa S. Pharmacologic Differences of Sulfonylureas and the Risk of Adverse Cardiovascular and Hypoglycemic Events. Diabetes Care. 2017;40:1506-1513 pubmed publisher
    ..Adjusted hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models, comparing use of pancreas-nonspecific, long-..
  68. Midena E, Bini S. Multimodal retinal imaging of diabetic macular edema: toward new paradigms of pathophysiology. Graefes Arch Clin Exp Ophthalmol. 2016;254:1661-8 pubmed publisher
    ..Hyperreflective intraretinal spots (HRS) have been detected on OCT scans through the retinal layers, with a presumptive migration pattern towards the ..
  69. Cardwell C, Spence A, Hughes C, Murray L. Statin use after esophageal cancer diagnosis and survival: A population based cohort study. Cancer Epidemiol. 2017;48:124-130 pubmed publisher
    ..intervals (CIs) by post-diagnostic statin use (using a 6 month lag to reduce reverse causation) and to adjust these HRs for potential confounders...
  70. Jacobs H, Zeeb H, Hoffmann F. Incidence Rates of and Mortality after Hip Fracture among German Nursing Home Residents. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..Using Cox regression, we studied mortality and estimated time-dependent hazard ratios (HRs)...
  71. Hou H, Lin C, Leung C. Integrating Macular Ganglion Cell Inner Plexiform Layer and Parapapillary Retinal Nerve Fiber Layer Measurements to Detect Glaucoma Progression. Ophthalmology. 2018;125:822-831 pubmed publisher
    ..99; 95% CI, 1.48-6.02), after adjusting for baseline covariates. The HRs for likely and possible VF progression were 3.48 (95% CI, 1.51-8.01) and 2.74 (95% CI, 1.26-5...
  72. Ng D, Wu D, Wood B, Fromm J. Computer-aided detection of rare tumor populations in flow cytometry: an example with classic Hodgkin lymphoma. Am J Clin Pathol. 2015;144:517-24 pubmed publisher
    ..lymphoma (cHL) by flow cytometry (FC) relies on an observer gating rare populations of Hodgkin/Reed Sternberg (HRS) cells...
  73. Holm J, Li J, Darabi H, Eklund M, Eriksson M, Humphreys K, et al. Associations of Breast Cancer Risk Prediction Tools With Tumor Characteristics and Metastasis. J Clin Oncol. 2016;34:251-8 pubmed publisher
    ..Cox proportional hazard models were used to estimate hazard ratios (HRs) of distant metastasis...
  74. Endres H, Kaufmann Kolle P, Steeb V, Bauer E, Böttner C, Thürmann P. Association between Potentially Inappropriate Medication (PIM) Use and Risk of Hospitalization in Older Adults: An Observational Study Based on Routine Data Comparing PIM Use with Use of PIM Alternatives. PLoS ONE. 2016;11:e0146811 pubmed publisher
    ..health insurer on 392,337 ambulatory patients aged ≥65 years, were used to estimate adjusted hazard ratios (HRs) for hospitalization associated with incident PIM use. Observation period was January 2009 -December 2010...
  75. Sung K, Park H, Kim M, Reaven G. Metabolic markers associated with insulin resistance predict type 2 diabetes in Koreans with normal blood pressure or prehypertension. Cardiovasc Diabetol. 2016;15:47 pubmed publisher
    ..also developed to a significantly greater degree in subjects within the highest quartile of TG/HDL-C ratios, with HRs varying from 2.91 (1.63-2.58) in women with prehypertension (P < 0.001) to 1.77 (1.12-2.81, P < 0...
  76. Schinkel J, Shao S, Zahm S, McGlynn K, Shriver C, Zhu K. Overall and recurrence-free survival among black and white bladder cancer patients in an equal-access health system. Cancer Epidemiol. 2016;42:154-8 pubmed publisher
    ..We assessed the relationship between race and outcomes of interest using Cox proportional hazard ratios (HRs) for all, non-muscle invasive (NMIBC), and muscle invasive (MIBC) bladder cancers, separately...
  77. Wang Y, Li Y, Yin L, Pu H. Can Diffusion-weighted Magnetic Resonance Imaging Predict Survival in Patients with Cervical Cancer? A Meta-Analysis. Eur J Radiol. 2016;85:2174-2181 pubmed publisher
    ..Combined estimates of hazard ratios (HRs) were derived. Nine studies involving a total of 796 patients (mean/median age from 45.0 years to 62...
  78. Park S, Seo M, Ryoo J, Kim M, Choi J, Shin H, et al. Urinary albumin excretion within the normal range predicts the development of diabetes in Korean men. Diabetes Res Clin Pract. 2015;109:427-33 pubmed publisher
    ..Cox proportional hazards analysis was used to evaluate the independent hazard ratios (HRs) for diabetes according to the UACR levels of their quartile group...
  79. Huang J, Jian Z, Nfor O, Ku W, Ko P, Lung C, et al. The effects of pulmonary diseases on histologic types of lung cancer in both sexes: a population-based study in Taiwan. BMC Cancer. 2015;15:834 pubmed publisher
    ..18 (95 % CI, 1.09-1.28) for asthma, and 1.50 (95 % CI, 1.42-1.59) and 1.33 (95 % CI, 1.25-1.42) for COPD. The HRs of small cell carcinoma were respectively 1.24 (95 % CI, 1.01-1.52) and 2.23 (95 % CI, 1.17-4.25) for TB, 1...
  80. Maurizio E, Wiśniewski J, Ciani Y, Amato A, Arnoldo L, Penzo C, et al. Translating Proteomic Into Functional Data: An High Mobility Group A1 (HMGA1) Proteomic Signature Has Prognostic Value in Breast Cancer. Mol Cell Proteomics. 2016;15:109-23 pubmed publisher
    ..in breast cancer gene expression meta-data sets, resulting in an HMGA1 protein signature composed of 21 members (HRS, HMGA1 reduced signature)...
  81. Chi K, Kheoh T, Ryan C, Molina A, Bellmunt J, Vogelzang N, et al. A prognostic index model for predicting overall survival in patients with metastatic castration-resistant prostate cancer treated with abiraterone acetate after docetaxel. Ann Oncol. 2016;27:454-60 pubmed publisher
    ..n = 321, 40%) and poor (n = 107, 13%) prognosis groups based on the number of risk factors and relative HRs. The C-index was 0.70 ± 0.014. The model was validated by the external dataset (n = 286)...
  82. Zhao H, Wang S, Song C, Zha Y, Li L. The prognostic value of MGMT promoter status by pyrosequencing assay for glioblastoma patients' survival: a meta-analysis. World J Surg Oncol. 2016;14:261 pubmed
    ..Using Stata 11.0, the summarized hazard ratios (HRs) for overall survival (OS) and the progression-free survival (PFS) with 95 % confidence interval (CI) were ..
  83. Andrade J, Macle L, Nattel S, Verma A, Cairns J. Contemporary Atrial Fibrillation Management: A Comparison of the Current AHA/ACC/HRS, CCS, and ESC Guidelines. Can J Cardiol. 2017;33:965-976 pubmed publisher
  84. Paccou J, D Angelo S, Rhodes A, Curtis E, Raisi Estabragh Z, Edwards M, et al. Prior fragility fracture and risk of incident ischaemic cardiovascular events: results from UK Biobank. Osteoporos Int. 2018;29:1321-1328 pubmed publisher
    ..64; 95%CI: 0.88, 3.07); p = 0.121]. HRs for admission with angina were lower in women, and neither age- nor fully adjusted relationships attained ..
  85. Yan M, Kumachev A, Siu L, Chan K. Chemoradiotherapy regimens for locoregionally advanced nasopharyngeal carcinoma: A Bayesian network meta-analysis. Eur J Cancer. 2015;51:1570-9 pubmed publisher
    ..Overall survival (OS) was the primary outcome of interest, and hazard ratios (HRs) were extracted using the Parmar method. Bayesian NMAs with random effects were conducted using WinBUGS...
  86. Nechuta S, Shu X, Yang G, Cai H, Gao Y, Li H, et al. Adolescent exercise in association with mortality from all causes, cardiovascular disease, and cancer among middle-aged and older Chinese women. Cancer Epidemiol Biomarkers Prev. 2015;24:1270-6 pubmed publisher
    ..other adolescent factors, adolescent exercise was associated with reduced risk of cancer, CVD, and total mortality [HRs (95% CI), 0.83 (0.72-0.95), 0.83 (0.70-0.98), and 0.78 (0.71-0.85), respectively for ≤1...
  87. Chen J, Ju H, Yuan X, Wang T, Lai B. SOX4 is a potential prognostic factor in human cancers: a systematic review and meta-analysis. Clin Transl Oncol. 2016;18:65-72 pubmed publisher
    ..colorectal cancer patients' recurrence-free survival and gastric cancer patients' overall survival, and the pooled HRs (95 % CI) were 1.73 (95 % CI 1.04-2.88) and 3.74 (95 % CI 1.04-13.45), respectively...
  88. Tehranifar P, Goyal A, Phelan J, Link B, Liao Y, Fan X, et al. Age at cancer diagnosis, amenability to medical interventions, and racial/ethnic disparities in cancer mortality. Cancer Causes Control. 2016;27:553-60 pubmed publisher
    ..For example, in the youngest (20-34) and oldest (80-99) age groups, the adjusted hazard ratios (HRs) for African-Americans versus whites with least amenable cancers were, respectively, 1.26 (95% CI 1.02, 1.55) and 0...
  89. Udumyan R, Montgomery S, Fang F, Almroth H, Valdimarsdottir U, Ekbom A, et al. Beta-Blocker Drug Use and Survival among Patients with Pancreatic Adenocarcinoma. Cancer Res. 2017;77:3700-3707 pubmed publisher
    ..adjusted for sociodemographic factors, tumor characteristics, comorbidity score, and other medications to estimate HRs and 95% confidence intervals (CI) for cancer-specific mortality associated with beta-blocker use during the 90-day ..
  90. Ugai T, Matsuo K, Sawada N, Iwasaki M, Yamaji T, Shimazu T, et al. Coffee and Green Tea Consumption and Subsequent Risk of Malignant Lymphoma and Multiple Myeloma in Japan: The Japan Public Health Center-based Prospective Study. Cancer Epidemiol Biomarkers Prev. 2017;26:1352-1356 pubmed publisher
    ..b>HRs and 95% confidence intervals were estimated using a Cox regression model adjusted for potential confounders as a ..
  91. Ju W, Zhang M, Wilson K, Petrus M, Bamford R, Zhang X, et al. Augmented efficacy of brentuximab vedotin combined with ruxolitinib and/or Navitoclax in a murine model of human Hodgkin's lymphoma. Proc Natl Acad Sci U S A. 2016;113:1624-9 pubmed publisher
    ..Hodgkin's Reed-Sternberg (HRS) cells secrete cytokines including IL-6 and -13, leading to constitutive activation of JAK/STAT signaling...