SRP9

Summary

Gene Symbol: SRP9
Description: signal recognition particle 9
Alias: ALURBP, signal recognition particle 9 kDa protein, signal recognition particle 9kD, signal recognition particle 9kDa
Species: human
Products:     SRP9

Top Publications

  1. Weichenrieder O, Wild K, Strub K, Cusack S. Structure and assembly of the Alu domain of the mammalian signal recognition particle. Nature. 2000;408:167-73 pubmed
    The Alu domain of the mammalian signal recognition particle (SRP) comprises the heterodimer of proteins SRP9 and SRP14 bound to the 5' and 3' terminal sequences of SRP RNA...
  2. Mary C, Scherrer A, Huck L, Lakkaraju A, Thomas Y, Johnson A, et al. Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein. RNA. 2010;16:969-79 pubmed publisher
    ..during targeting to ensure efficient translocation of the preprotein, and this function of SRP is dependent on SRP9/14...
  3. Massenet S. In vivo assembly of eukaryotic signal recognition particle: A still enigmatic process involving the SMN complex. Biochimie. 2019;: pubmed publisher
    ..In mammals, SRP contains one RNA molecule, 7SL RNA, and six proteins: SRP9, 14, 19, 54, 68 and 72...
  4. Hessel E, de Wit M, Wolterink Donselaar I, Karst H, de Graaff E, van Lith H, et al. Identification of Srp9 as a febrile seizure susceptibility gene. Ann Clin Transl Neurol. 2014;1:239-50 pubmed publisher
    ..trait locus (QTL1) for hyperthermia-induced FS on mouse chromosome 1, containing the signal recognition particle 9 (Srp9) gene. Effects of differential Srp9 expression were assessed in vivo and in vitro...
  5. Berger A, Ivanova E, Gareau C, Scherrer A, Mazroui R, Strub K. Direct binding of the Alu binding protein dimer SRP9/14 to 40S ribosomal subunits promotes stress granule formation and is regulated by Alu RNA. Nucleic Acids Res. 2014;42:11203-17 pubmed publisher
    ..Our study describes a novel function of the protein heterodimer SRP9/14 and Alu RNA in SG formation and disassembly...
  6. Bousset L, Mary C, Brooks M, Scherrer A, Strub K, Cusack S. Crystal structure of a signal recognition particle Alu domain in the elongation arrest conformation. RNA. 2014;20:1955-62 pubmed publisher
    ..In eukaryotes, the Alu domain, which comprises the 5' and 3' extremities of the SRP RNA bound to the SRP9/14 heterodimer, is thought to interact with the ribosome to pause translation elongation during membrane docking...
  7. Wildschutte J, Baron A, Diroff N, Kidd J. Discovery and characterization of Alu repeat sequences via precise local read assembly. Nucleic Acids Res. 2015;43:10292-307 pubmed publisher
    ..The sites of truncation coincide with stem-loop structures and SRP9/14 binding sites in the Alu RNA, implicating L1 ORF2p pausing in the generation of 5' truncations...
  8. Ahl V, Keller H, Schmidt S, Weichenrieder O. Retrotransposition and Crystal Structure of an Alu RNP in the Ribosome-Stalling Conformation. Mol Cell. 2015;60:715-727 pubmed publisher
    ..RNA sufficient for effective retrotransposition and determined a high-resolution structure of its complex with the SRP9/14 proteins...
  9. Nabet B, Qiu Y, Shabason J, Wu T, Yoon T, Kim B, et al. Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer. Cell. 2017;170:352-366.e13 pubmed publisher
    ..cells results in a POL3-driven increase in RN7SL1, an endogenous RNA normally shielded by RNA binding proteins SRP9/14...

More Information

Publications19

  1. Ohi K, Shimada T, Yasuyama T, Kimura K, Uehara T, Kawasaki Y. Spatial and temporal expression patterns of genes around nine neuroticism-associated loci. Prog Neuropsychopharmacol Biol Psychiatry. 2017;77:164-171 pubmed publisher
    ..The spatial expression analysis revealed that the nearest genes (GRIK3, SRP9, KLHL2, PTPRD, ELAVL2, CRHR1 and CELF4) from index single-nucleotide polymorphisms (SNPs) at the nine loci were ..
  2. Rho J, Qin S, Wang J, Roehrl M. Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer. J Proteome Res. 2008;7:2959-72 pubmed publisher
    ..hemoglobin alpha subunit (HBA), peroxiredoxin-1 (PRDX1), argininosuccinate synthase (ASSY), and signal recognition particle 9 kDa protein (SRP9)...
  3. Maity T, Leonard C, Rose M, Fried H, Weeks K. Compartmentalization directs assembly of the signal recognition particle. Biochemistry. 2006;45:14955-64 pubmed
    ..Our findings emphasize that spatial compartmentalization provides an additional level of regulation that prevents competition among components and can function to promote native assembly of the eukaryotic SRP. ..
  4. Piazzon N, Schlotter F, Lefebvre S, Dodré M, Mereau A, Soret J, et al. Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle. Nucleic Acids Res. 2013;41:1255-72 pubmed publisher
    ..Our data show that reduced levels of the SMN protein lead to defect in SRP steady-state level and describe the SMN complex as the first identified cellular factor required for SRP biogenesis. ..
  5. Su Z, Kang D, Chen Y, Pekarskaya O, Chao W, Volsky D, et al. Identification of gene products suppressed by human immunodeficiency virus type 1 infection or gp120 exposure of primary human astrocytes by rapid subtraction hybridization. J Neurovirol. 2003;9:372-89 pubmed
  6. Hsu K, Chang D, Maraia R. Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9. J Biol Chem. 1995;270:10179-86 pubmed
    ..This region of 7SL RNA together with 9- and 14-kDa polypeptides (SRP9/14) regulates translational elongation of ribosomes engaged by SRP...
  7. Ivanova E, Berger A, Scherrer A, Alkalaeva E, Strub K. Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits. Nucleic Acids Res. 2015;43:2874-87 pubmed publisher
    ..Their expression is upregulated following stress and viral infection, and they associate with the SRP9/14 protein dimer in the cytoplasm forming Alu RNPs...
  8. Gold M, Fresco J. A Role for the Mutagenic DNA Self-Catalyzed Depurination Mechanism in the Evolution of 7SL-Derived RNAs. J Mol Evol. 2017;85:84-98 pubmed publisher
    ..intermediates, the same self-depurination sequence overlaps motifs necessary for successful transcription and SRP9/14 (signal recognition particle) binding; hence, mutations in this region could disrupt RNA activity...
  9. Strub K, Walter P. Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA. Mol Cell Biol. 1990;10:777-84 pubmed
    ..This function is carried out by the Alu domain, which consists of two proteins, SRP9 and SRP14, and the portion of SRP (7SL) RNA which is homologous to the Alu family of repetitive sequences...
  10. Bovia F, Bui N, Strub K. The heterodimeric subunit SRP9/14 of the signal recognition particle functions as permuted single polypeptide chain. Nucleic Acids Res. 1994;22:2028-35 pubmed
    ..The 9 kD (SRP9) and the 14 kD (SRP14) subunits of SRP are required to confer elongation arrest activity to the particle...