Gene Symbol: SRp20
Description: serine and arginine rich splicing factor 3
Alias: SFRS3, SRp20, serine/arginine-rich splicing factor 3, pre-mRNA splicing factor SRp20, pre-mRNA-splicing factor SRP20, splicing factor, arginine/serine-rich 3, splicing factor, arginine/serine-rich, 20-kD
Species: human
Products:     SRp20

Top Publications

  1. Bedard K, Daijogo S, Semler B. A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation. EMBO J. 2007;26:459-67 pubmed
    ..This work demonstrates that a nucleo-cytoplasmic SR protein, SRp20, functions in internal ribosome entry site (IRES)-mediated translation of a viral RNA...
  2. Gonçalves V, Matos P, Jordan P. The beta-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression. RNA. 2008;14:2538-49 pubmed publisher
    ..Here we report the splicing factor SRp20 as a novel target gene of beta-catenin/TCF4 signaling...
  3. Caceres J, Screaton G, Krainer A. A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes Dev. 1998;12:55-66 pubmed
    ..We show here that whereas some human SR proteins are confined to the nucleus, three of them-SF2/ASF, SRp20, and 9G8-shuttle rapidly and continuously between the nucleus and the cytoplasm...
  4. Hargous Y, Hautbergue G, Tintaru A, Skrisovska L, Golovanov A, Stevenin J, et al. Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. EMBO J. 2006;25:5126-37 pubmed
    The sequence-specific RNA-binding proteins SRp20 and 9G8 are the smallest members of the serine- and arginine-rich (SR) protein family, well known for their role in splicing...
  5. Le Hir H, Moore M, Maquat L. Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions. Genes Dev. 2000;14:1098-108 pubmed
    ..Such proteins could influence downstream metabolic events in vivo such as mRNA transport, translation, and nonsense-mediated decay. ..
  6. Sen S, Talukdar I, Webster N. SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing. Mol Cell Biol. 2009;29:871-80 pubmed publisher
    ..We identified binding of SRp20 and SF2/ASF to the exonic enhancers and CUG-BP1 to the exonic silencer by RNA affinity chromatography...
  7. Manley J, Krainer A. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). Genes Dev. 2010;24:1073-4 pubmed publisher
  8. Escudero Paunetto L, Li L, Hernandez F, Sandri Goldin R. SR proteins SRp20 and 9G8 contribute to efficient export of herpes simplex virus 1 mRNAs. Virology. 2010;401:155-64 pubmed publisher
    ..SR proteins SRp20 and 9G8 interact with TAP/NXF1 and mediate export of some cellular RNAs...
  9. Gui J, Lane W, Fu X. A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature. 1994;369:678-82 pubmed

More Information


  1. Jia R, Liu X, Tao M, Kruhlak M, Guo M, Meyers C, et al. Control of the papillomavirus early-to-late switch by differentially expressed SRp20. J Virol. 2009;83:167-80 pubmed publisher
    ..Here, we report that SRp20, a cellular splicing factor, controls the early-to-late switch via interactions with A/C-rich RNA elements...
  2. Zahler A, Lane W, Stolk J, Roth M. SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev. 1992;6:837-47 pubmed
    ..In four of the family members a repeated protein sequence that encompasses an RNA recognition motif was observed. We discuss the potential role of this highly conserved, functionally related set of proteins in pre-mRNA splicing. ..
  3. De la Mata M, Kornblihtt A. RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20. Nat Struct Mol Biol. 2006;13:973-80 pubmed
    ..We found that the CTD is required for the inhibitory action of the serine/arginine-rich (SR) protein SRp20 on the inclusion of a fibronectin cassette exon in the mature mRNA...
  4. Huang Y, Steitz J. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA. Mol Cell. 2001;7:899-905 pubmed
    ..transient transfection, and Xenopus oocyte microinjection, we find that the nucleocytoplasmic shuttling proteins SRp20 and 9G8 interact specifically with a 22-nt RNA element from the histone H2a gene to promote the export of ..
  5. Loomis R, Naoe Y, Parker J, Savic V, Bozovsky M, Macfarlan T, et al. Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. Mol Cell. 2009;33:450-61 pubmed publisher
    ..We report here that two SR protein splicing factors, SRp20 and ASF/SF2, associate with interphase chromatin, are released from hyperphosphorylated mitotic chromosomes, but ..
  6. Jia R, Li C, McCoy J, Deng C, Zheng Z. SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance. Int J Biol Sci. 2010;6:806-26 pubmed
    ..We found that splicing factor SRp20 (SFRS3) is highly expressed in cancers...
  7. Zhdanov D, Plyasova A, Gladilina Y, Pokrovsky V, Grishin D, Grachev V, et al. Inhibition of telomerase activity by splice-switching oligonucleotides targeting the mRNA of the telomerase catalytic subunit affects proliferation of human CD4+ T lymphocytes. Biochem Biophys Res Commun. 2019;509:790-796 pubmed publisher
    ..SSOs that blocked the binding of a single splicing regulatory protein, SRp20 or SRp40, to its site within intron 8 of hTERT pre-mRNA demonstrated rather moderate capacities to induce AS and ..
  8. Jain A, Wordinger R, Yorio T, Clark A. Spliceosome protein (SRp) regulation of glucocorticoid receptor isoforms and glucocorticoid response in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2012;53:857-66 pubmed publisher
    ..mRNA splicing is mediated by spliceosomes, which include serine-arginine rich proteins (SRps). The purpose of this study was to determine whether specific SRps regulate levels of these isoforms and thereby GC response in TM cells...
  9. Zheng X, Cho S, Moon H, Loh T, Jang H, Shen H. Detecting RNA-Protein Interaction Using End-Labeled Biotinylated RNA Oligonucleotides and Immunoblotting. Methods Mol Biol. 2016;1421:35-44 pubmed publisher
    ..Interactions between the SMN RNA and the PSF protein and between the caspase-2 RNA and the SRSF3 protein (SRp20) in nuclear extract prepared from HeLa cells are illustrated as examples.
  10. Bartels H, Luban J. Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA. Retrovirology. 2014;11:73 pubmed publisher
    ..Conversely, Gag polyprotein synthesis was decreased by NXF1 knockdown. Finally, overexpression of SRp20, a shuttling protein that binds to NXF1 and promotes NXF1 binding to RNA, also increased gag RNA loading onto ..
  11. Kim K, Nguyen T, Li S, Nguyen T. SRSF3 recruits DROSHA to the basal junction of primary microRNAs. RNA. 2018;: pubmed publisher
    ..In addition, CNNC, located ~17 nucleotides from the Microprocessor cleavage site, interacts with SRSF3 (SRp20) to stimulate Microprocessor to process pri-miRNAs. The mechanism underlying this stimulation, however, is unknown...
  12. Park R, Miller G. Epstein-Barr Virus-Induced Nodules on Viral Replication Compartments Contain RNA Processing Proteins and a Viral Long Noncoding RNA. J Virol. 2018;92: pubmed publisher
    ..VINORCs were composed of viral (BMLF1 and BGLF5) and cellular (SC35, SON, SRp20, and NXF1) proteins that mediate pre-mRNA processing and mRNA export...
  13. Wang C, Li L, Yin Z, Zhang Q, Zhao H, Tao R, et al. An indel polymorphism within pre-miR3131 confers risk for hepatocellular carcinoma. Carcinogenesis. 2017;38:168-176 pubmed publisher
    ..could affect the expression level of mature miR-3131 probably through disturbing the binding of splicing factor SRp20 with pre-miR-3131...
  14. Majerciak V, Lu M, Li X, Zheng Z. Attenuation of the suppressive activity of cellular splicing factor SRSF3 by Kaposi sarcoma-associated herpesvirus ORF57 protein is required for RNA splicing. RNA. 2014;20:1747-58 pubmed publisher
    ..Here, we identified serine/arginine-rich splicing factor 3 (SRSF3, formerly known as SRp20) as a cellular cofactor involved in ORF57-mediated splicing of KSHV K8β RNA...
  15. Xiong X, Xu C, Zhang Y, Li X, Wang B, Wang F, et al. BRG1 variant rs1122608 on chromosome 19p13.2 confers protection against stroke and regulates expression of pre-mRNA-splicing factor SFRS3. Hum Genet. 2014;133:499-508 pubmed publisher
    ..013). Allele T of rs1122608 was associated with an increased expression level of SFRS3 encoding an mRNA splicing regulator, but not with the expression of BRG1/SMARCA4 or LDLR (located 36 kb from ..
  16. Klymenko T, Hernández López H, MacDonald A, Bodily J, Graham S. Human Papillomavirus E2 Regulates SRSF3 (SRp20) To Promote Capsid Protein Expression in Infected Differentiated Keratinocytes. J Virol. 2016;90:5047-58 pubmed publisher
    ..caused increased levels of the cellular SR splicing factors (SRSFs) SRSF1 (ASF/SF2), SRSF2 (SC35), and SRSF3 (SRp20)...
  17. Buoso E, Galasso M, Ronfani M, Serafini M, Lanni C, Corsini E, et al. Role of spliceosome proteins in the regulation of glucocorticoid receptor isoforms by cortisol and dehydroepiandrosterone. Pharmacol Res. 2017;120:180-187 pubmed publisher
    ..SR)-Rich Splicing Factors (SRSF) regulating GR splicing, specifically SRSF9 and SRSF3 also known as SRp30c and SRp20 respectively...
  18. Ajiro M, Jia R, Wang R, Deng C, Zheng Z. Adapted Resistance to the Knockdown Effect of shRNA-Derived Srsf3 siRNAs in Mouse Littermates. Int J Biol Sci. 2015;11:1248-56 pubmed publisher
    ..In this report, transgenic mouse lines were created for conditional knockdown of Srsf3 (SRp20) expression in liver and mammary gland tissues by expressing Srsf3-specific shRNAs driven by a U6 promoter...
  19. Fitzgerald K, Semler B. Poliovirus infection induces the co-localization of cellular protein SRp20 with TIA-1, a cytoplasmic stress granule protein. Virus Res. 2013;176:223-31 pubmed publisher
    ..Work described here examined the punctate pattern of SRp20 (a host cell mRNA splicing protein) localization in the cytoplasm of poliovirus-infected cells, demonstrating the ..
  20. Fingert J, Alward W, Wang K, Yorio T, Clark A. Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders. Mol Vis. 2010;16:596-601 pubmed
    ..Iowa Ophthalmology Clinics after IRB approved consent. Genotyping of DNA samples for 48 SNPs in SFRS3, SFRS5, SFRS9, FKBP4, FKBP5, and NR3C1 was done at GeneSeek using a mass spectroscopy based system...
  21. He X, Arslan A, Pool M, Ho T, Darcy K, Coon J, et al. Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer. Oncogene. 2011;30:356-65 pubmed publisher
    Our previous study revealed that two splicing factors, polypyrimidine tract-binding protein (PTB) and SRp20, were upregulated in epithelial ovarian cancer (EOC) and knockdown of PTB expression inhibited ovarian tumor cell growth and ..
  22. Dettwiler S, Aringhieri C, Cardinale S, Keller W, Barabino S. Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. J Biol Chem. 2004;279:35788-97 pubmed
    ..protein interactions with other 3'-end-processing factors are detected with CF I(m)25, CF I(m)68 interacts with SRp20, 9G8, and hTra2beta, members of the SR family of splicing factors, via its C-terminal alternating charge domain...
  23. Chang W, Niu D, Lu C, Lin S, Liu T, Chang J. Modulation the alternative splicing of GLA (IVS4+919G>A) in Fabry disease. PLoS ONE. 2017;12:e0175929 pubmed publisher
    ..PSIP1, an adapter of H3K36me3, together with Hsp70 and NONO were recruited and formed a complex with SF2/ASF and SRp20, which further promoted GLA splicing...
  24. Suchanek A, Salati L. Construction and evaluation of an adenoviral vector for the liver-specific expression of the serine/arginine-rich splicing factor, SRSF3. Plasmid. 2015;82:1-9 pubmed publisher
    Serine/arginine-rich splicing factor-3 (SRSF3), alternatively known as SRp20, is a member of the highly-conserved SR protein family of mRNA splicing factors...
  25. Boyne J, Colgan K, Whitehouse A. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. PLoS Pathog. 2008;4:e1000194 pubmed publisher
    ..Together, these data provide the first direct evidence that the complete hTREX complex is essential for the export of KSHV intronless mRNAs and infectious virus production. ..
  26. Kotlajich M, Hertel K. Death by splicing: tumor suppressor RBM5 freezes splice-site pairing. Mol Cell. 2008;32:162-4 pubmed publisher
    ..In a recent issue of Molecular Cell, Bonnal et al. (2008) demonstrate that the tumor suppressor gene RBM5 regulates alternative splicing of Fas pre-mRNA by interfering with splice-site pairing. ..
  27. Fitzgerald K, Semler B. Re-localization of cellular protein SRp20 during poliovirus infection: bridging a viral IRES to the host cell translation apparatus. PLoS Pathog. 2011;7:e1002127 pubmed publisher
    ..The interaction of cellular proteins PCBP2 and SRp20 in extracts from poliovirus-infected cells has been previously described, and these two proteins were shown to ..
  28. Kim H, Shin C, Lee H, Choi K, Nam D, Ohn T, et al. MicroRNA-1908-5p contributes to the oncogenic function of the splicing factor SRSF3. Oncotarget. 2017;8:8342-8355 pubmed publisher
    ..The splicing factor SRSF3, also termed SRp20, is the smallest member of the SR protein family and is a known proto-oncogene...
  29. Shnyreva M, Schullery D, Suzuki H, Higaki Y, Bomsztyk K. Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein. J Biol Chem. 2000;275:15498-503 pubmed
    ..Several novel protein partners were identified, including Y-box-binding protein (YB-1), splicing factors 9G8 and SRp20, DNA-methyltransferase, hnRNP L, and hnRNP U...
  30. Saeki K, Yasugi E, Okuma E, Breit S, Nakamura M, Toda T, et al. Proteomic analysis on insulin signaling in human hematopoietic cells: identification of CLIC1 and SRp20 as novel downstream effectors of insulin. Am J Physiol Endocrinol Metab. 2005;289:E419-28 pubmed
    ..We identified SRp20, a splicing factor, and CLIC1, an intracellular chloride ion channel, as novel downstream effectors besides ..
  31. Park R, Chen J, Kim J, Jeong S, Ohn T. Splicing factor SRSF3 represses the translation of programmed cell death 4 mRNA by associating with the 5'-UTR region. Cell Death Differ. 2014;21:481-90 pubmed publisher
    ..In summary, our data suggest that the oncogenic potential of SRSF3 might be realized, in part, through the translational repression of PDCD4 mRNA. ..
  32. Jang H, Lee M, Loh T, Choi S, Oh H, Moon H, et al. Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8. Biochim Biophys Acta. 2014;1839:25-32 pubmed publisher
    ..Here we show that knockdown of SRSF3 (also known as SRp20) with siRNA induced significant increase of endogenous exon 9 inclusion...
  33. Tripodis N, Mason R, Humphray S, Davies A, Herberg J, Trowsdale J, et al. Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. Genome Res. 1998;8:631-43 pubmed
    ..The close linkage of the BAK and CSBP genes to the MHC is of interest because of their possible involvement in autoimmune disease. ..
  34. Zhang W, Wu J. Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing. Mol Cell Biol. 1998;18:676-84 pubmed
    ..Together, these results demonstrate that Sip1 is a novel RS domain-containing protein required for pre-mRNA splicing and that the functional role of Sip1 in splicing is distinct from those of known RS domain-containing splicing factors. ..
  35. Corbo C, Orru S, Gemei M, Noto R, Mirabelli P, Imperlini E, et al. Protein cross-talk in CD133+ colon cancer cells indicates activation of the Wnt pathway and upregulation of SRp20 that is potentially involved in tumorigenicity. Proteomics. 2012;12:2045-59 pubmed publisher
    ..Interestingly, we observed upregulation of the splicing factor SRp20, a newly identified target gene of the Wnt/?-catenin pathway, and we demonstrated a direct cause-effect ..
  36. Walsh C, Suchanek A, Cyphert T, Kohan A, Szeszel Fedorowicz W, Salati L. Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver. J Biol Chem. 2013;288:2816-28 pubmed publisher
    ..Nutritional regulation of other SR proteins presents a regulatory mechanism that could cause widespread changes in mRNA splicing. Nutrients are therefore novel regulators of mRNA splicing. ..
  37. Barnard D, Patton J. Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. Mol Cell Biol. 2000;20:3049-57 pubmed
    ..In contrast, p86 activates splicing in the presence of SRp20. Thus, it appears that pairwise combination of p86 with specific SR proteins leads to altered splicing efficiency ..
  38. Moura Alves P, Neves Costa A, Raquel H, Pacheco T, D Almeida B, Rodrigues R, et al. An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1? secretion. PLoS ONE. 2011;6:e19829 pubmed publisher
    ..Silencing of SFRS3 increased IL-1? secretion due to elevation of IL-1? and caspase-1 mRNA in addition to active caspase-1 levels...
  39. Elliott D, Bourgeois C, Klink A, Stevenin J, Cooke H. A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection. Proc Natl Acad Sci U S A. 2000;97:5717-22 pubmed
    ..Our results suggest that RBM protein is an evolutionarily conserved mammalian splicing regulator which operates as a germ cell-specific cofactor for more ubiquitously expressed pre-mRNA splicing activators. ..
  40. Barnard D, Li J, Peng R, Patton J. Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins. RNA. 2002;8:526-33 pubmed
    ..Here, we show that SRrp86 can activate SRp20 and repress SC35 in a dose-dependent manner both in vitro and in vivo...
  41. Ajiro M, Jia R, Yang Y, Zhu J, Zheng Z. A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells. Nucleic Acids Res. 2016;44:1854-70 pubmed publisher
    ..We recently described serine/arginine-rich splicing factor 3 (SRSF3 or SRp20) being a proto-oncogene...
  42. Zhu S, Chen Z, Katsha A, Hong J, Belkhiri A, el Rifai W. Regulation of CD44E by DARPP-32-dependent activation of SRp20 splicing factor in gastric tumorigenesis. Oncogene. 2016;35:1847-56 pubmed publisher
    ..001). Further experiments showed that DARPP-32 regulates the expression of SRp20 splicing factor and co-exists with it in the same protein complex...
  43. Park S, Jeong S. SRSF3 represses the expression of PDCD4 protein by coordinated regulation of alternative splicing, export and translation. Biochem Biophys Res Commun. 2016;470:431-438 pubmed publisher
    ..We propose that SRSF3 could act as a coordinator of the expression of PDCD4 protein via two mechanisms on two alternatively spliced mRNA isoforms. ..
  44. Peiqi L, Zhaozhong G, Yaotian Y, Jun J, Jihua G, Rong J. Expression of SRSF3 is Correlated with Carcinogenesis and Progression of Oral Squamous Cell Carcinoma. Int J Med Sci. 2016;13:533-9 pubmed publisher
    ..Our results suggested that SRSF3 is associated with the initiation and development of OSCC and may be a biomarker and therapeutic target of OSCC. ..
  45. Cammas A, Lacroix Triki M, Pierredon S, Le Bras M, Iacovoni J, Teulade Fichou M, et al. hnRNP A1-mediated translational regulation of the G quadruplex-containing RON receptor tyrosine kinase mRNA linked to tumor progression. Oncotarget. 2016;7:16793-805 pubmed publisher immunohistochemistry of the expression of hnRNP A1, hnRNPH, RBM9/FOX2, SRSF1/ASF/SF2, SRSF2/SC35, SRSF3/SRp20, SRSF7/9G8 in breast tumors shows that the expression of hnRNP A1, but not the other tested RBPs, is associated ..
  46. Xiao W, Adhikari S, Dahal U, Chen Y, Hao Y, Sun B, et al. Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing. Mol Cell. 2016;61:507-519 pubmed publisher
    ..we show that YTHDC1 promotes exon inclusion in targeted mRNAs through recruiting pre-mRNA splicing factor SRSF3 (SRp20) while blocking SRSF10 (SRp38) mRNA binding...
  47. Kano S, Nishida K, Kurebe H, Nishiyama C, Kita K, Akaike Y, et al. Oxidative stress-inducible truncated serine/arginine-rich splicing factor 3 regulates interleukin-8 production in human colon cancer cells. Am J Physiol Cell Physiol. 2014;306:C250-62 pubmed publisher
    ..Our results suggest that SRSF3-TR may function as a positive regulator of oxidative stress-initiated inflammatory responses in colon cancer cells. ..
  48. Liu B, Anderson S, Qiu J, Rubin B. Cardiac glycosides correct aberrant splicing of IKBKAP-encoded mRNA in familial dysautonomia derived cells by suppressing expression of SRSF3. FEBS J. 2013;280:3632-46 pubmed publisher
    ..These findings support the clinical evaluation of the impact of digoxin on the FD patient population. ..
  49. Fitzgerald K, Chase A, Cathcart A, Tran G, Semler B. Viral proteinase requirements for the nucleocytoplasmic relocalization of cellular splicing factor SRp20 during picornavirus infections. J Virol. 2013;87:2390-400 pubmed publisher
    ..We recently described the cytoplasmic relocalization of cellular splicing factor SRp20 during poliovirus infection...
  50. Ankö M, Morales L, Henry I, Beyer A, Neugebauer K. Global analysis reveals SRp20- and SRp75-specific mRNPs in cycling and neural cells. Nat Struct Mol Biol. 2010;17:962-70 pubmed publisher
    ..Using the GFP tag for immunopurification of mRNPs, mRNA targets of SRp20 and SRp75 were identified in cycling and neurally induced P19 cells...
  51. Gonçalves V, Matos P, Jordan P. Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways. Hum Mol Genet. 2009;18:3696-707 pubmed publisher
    ..Here we describe that ASF/SF2 and SRp20 are two antagonistic splicing factors regulating Rac1b expression in colorectal tumor cells...
  52. Tai H, Geisterfer M, Bell J, Moniwa M, Davie J, Boucher L, et al. CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins. Biochem Biophys Res Commun. 2003;308:170-6 pubmed
    ..Yeast two-hybrid assays also showed that CHD1 interacts with splicing proteins mKIAA0164, Srp20, and SAF-B. Splicing assays show that CHD1 overexpression can affect alternative splicing...
  53. Guo T, Boros L, Chan K, Hikim A, Hudson A, Swerdloff R, et al. Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors. J Androl. 2003;24:204-14 pubmed
    ..assays show that RBM7 interacts with splicing factor 3b subunit 2 (SAP145), and with the splicing regulator, SRp20. These interactions and the nuclear localization of RBM7 provide insights into its function in pre-mRNA processing ..
  54. Papoutsopoulou S, Nikolakaki E, Chalepakis G, Kruft V, Chevaillier P, Giannakouros T. SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1. Nucleic Acids Res. 1999;27:2972-80 pubmed
    ..These findings indicate that SRPK1 may have a role not only in pre-mRNA splicing, but also in the condensation of sperm chromatin. ..
  55. Ajiro M, Tang S, Doorbar J, Zheng Z. Serine/Arginine-Rich Splicing Factor 3 and Heterogeneous Nuclear Ribonucleoprotein A1 Regulate Alternative RNA Splicing and Gene Expression of Human Papillomavirus 18 through Two Functionally Distinguishable cis Elements. J Virol. 2016;90:9138-52 pubmed publisher
  56. Lin J, Lee Y, Tan T, Liang Y, Chuang H, Fann Y, et al. RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell. Biochim Biophys Acta Mol Cell Res. 2018;1865:259-272 pubmed publisher
    ..Collectively, RBM4-SRSF3-MAP4K4 constitutes a novel mechanism for manipulating the metastasis of CRC cells through the JNK1 signaling pathway. ..
  57. Tang Y, Horikawa I, Ajiro M, Robles A, Fujita K, Mondal A, et al. Downregulation of splicing factor SRSF3 induces p53?, an alternatively spliced isoform of p53 that promotes cellular senescence. Oncogene. 2013;32:2792-8 pubmed publisher
    ..SRSF3 (SRp20) is a member of a highly conserved family of splicing factors that have critical roles in key biological processes,..
  58. Guo J, Jia J, Jia R. PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells. Sci Rep. 2015;5:14548 pubmed publisher
    ..Overexpression of SRSF3, in turn, promotes PTBP2 expression. Our results suggest a novel mechanism for the overexpression of oncogenic splicing factor via impairing autoregulation in cancer cells. ..
  59. Gautrey H, Jackson C, Dittrich A, Browell D, Lennard T, Tyson Capper A. SRSF3 and hnRNP H1 regulate a splicing hotspot of HER2 in breast cancer cells. RNA Biol. 2015;12:1139-51 pubmed publisher
    ..SRSF3 and hnRNP H1 are the first splicing factors identified which regulate the production of these functionally distinct HER2 splice variants and therefore maybe important for the regulation of HER2 signaling. ..
  60. He X, Zhang P. Serine/arginine-rich splicing factor 3 (SRSF3) regulates homologous recombination-mediated DNA repair. Mol Cancer. 2015;14:158 pubmed publisher
    ..This new function of SRSF3 not only explains why overexpression of SRSF3 is required for ovarian cancer cell growth and survival but also offers a new insight into the mechanism of the neoplastic transformation. ..
  61. Wee C, Havens M, Jodelka F, Hastings M. Targeting SR proteins improves SMN expression in spinal muscular atrophy cells. PLoS ONE. 2014;9:e115205 pubmed publisher
    ..Our results identify novel regulators of SMN2 exon 7 inclusion, revealing potential targets for SMA therapeutics. ..
  62. Sen S, Langiewicz M, Jumaa H, Webster N. Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice. Hepatology. 2015;61:171-83 pubmed publisher
    ..Thus, these mice may provide an attractive model to discover the pathogenic mechanisms linking aberrant pre-messenger RNA splicing with liver damage, fibrosis, and HCC. ..
  63. Kano S, Nishida K, Nishiyama C, Akaike Y, Kajita K, Kurokawa K, et al. Truncated serine/arginine-rich splicing factor 3 accelerates cell growth through up-regulating c-Jun expression. J Med Invest. 2013;60:228-35 pubmed
    ..Our results suggest that stress-inducible SRSF3-TR may participate in the acceleration of cell growth through facilitating c-Jun-mediated G1 progression under stressful conditions. ..
  64. Hogewind B, Micheal S, Bakker B, Hoyng C, den Hollander A. Analysis of single nucleotide polymorphisms in the SFRS3 and FKBP4 genes in corticosteroid-induced ocular hypertension. Ophthalmic Genet. 2012;33:221-4 pubmed publisher
    ..This steroid response appears to be heritable and alleles in the SFRS3 and FKBP4 genes have recently been suggested to play a role...
  65. Wong J, Garner B, Halliday G, Kwok J. Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease. J Neurochem. 2012;123:159-71 pubmed publisher
    ..We found significant changes in serine/arginine protein 20 (Srp20) gene expression in AD cases and confirmed this using a second cohort of control/AD...
  66. Shepard P, Hertel K. The SR protein family. Genome Biol. 2009;10:242 pubmed publisher
    ..These activities point up the importance of SR proteins during the regulation of mRNA metabolism. ..
  67. Ayane M, Preuss U, Kohler G, Nielsen P. A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. Nucleic Acids Res. 1991;19:1273-8 pubmed
    ..In tissue culture, the expression of X16 mRNA can be induced by serum. The conserved protein motifs and expression pattern suggest that X16 could be involved in RNA processing correlating with cellular proliferation. ..
  68. Paz S, Krainer A, Caputi M. HIV-1 transcription is regulated by splicing factor SRSF1. Nucleic Acids Res. 2014;42:13812-23 pubmed
    ..Whereas in the later stages, Tat substitutes for SRSF1 by promoting release of the stalled polymerase and more efficient transcriptional elongation. ..
  69. Kralovicova J, Vorechovsky I. Alternative splicing of U2AF1 reveals a shared repression mechanism for duplicated exons. Nucleic Acids Res. 2017;45:417-434 pubmed publisher
    ..These results provide new insights into tissue-specific subfunctionalization of duplicated exons in vertebrate evolution and expand the repertoire of exon repression mechanisms that control alternative splicing. ..
  70. Kim H, Hwang S, Shin C, Choi K, Ohn T, Kim H. SRSF3-regulated miR-132/212 controls cell migration and invasion by targeting YAP1. Exp Cell Res. 2017;358:161-170 pubmed publisher
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    ..of SM complexes from SM-transfected cells led to the identification of the cellular SR splicing factor SRp20 as an SM-interacting protein...
  72. Wang H, Lin W, Dyck J, Yeakley J, Songyang Z, Cantley L, et al. SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. J Cell Biol. 1998;140:737-50 pubmed
    ..Together, our studies suggest that different SRPK family members may be uniquely regulated and targeted, thereby contributing to splicing regulation in different tissues, during development, or in response to signaling. ..