Gene Symbol: SRP19
Description: signal recognition particle 19
Alias: signal recognition particle 19 kDa protein, signal recognition particle 19kD, signal recognition particle 19kDa
Species: human
Products:     SRP19

Top Publications

  1. Kuglstatter A, Oubridge C, Nagai K. Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. Nat Struct Biol. 2002;9:740-4 pubmed
    ..The binding of SRP54 to the S domain of 7SL RNA is highly dependent on SRP19. Here we present the crystal structure of a human SRP ternary complex consisting of SRP19, the M domain of SRP54 ..
  2. Politz J, Yarovoi S, Kilroy S, Gowda K, Zwieb C, Pederson T. Signal recognition particle components in the nucleolus. Proc Natl Acad Sci U S A. 2000;97:55-60 pubmed
    ..The S domain contains unique sequence SRP RNA and four SRP proteins: SRP19, SRP54, SRP68, and SRP72...
  3. Wild K, Sinning I, Cusack S. Crystal structure of an early protein-RNA assembly complex of the signal recognition particle. Science. 2001;294:598-601 pubmed
    ..A crucial early step in SRP assembly in archaea and eukarya is the binding of protein SRP19 to specific sites on SRP RNA. Here we report the 1...
  4. Hainzl T, Huang S, Sauer Eriksson A. Structure of the SRP19 RNA complex and implications for signal recognition particle assembly. Nature. 2002;417:767-71 pubmed publisher
    ..The S domain of SRP comprises the 7S.S part of RNA bound to SRP19, SRP54 and the SRP68/72 heterodimer; SRP54 has the main role in recognizing signal sequences of nascent ..
  5. Tsai P, Huang S, Tsai H, Ma C, Hou M, Yang I, et al. The association between DNA copy number aberrations at chromosome 5q22 and gastric cancer. PLoS ONE. 2014;9:e106624 pubmed publisher
    ..We searched for a CNV and found a CNV (Variation 7468) containing part of the APC gene, the SRP19 gene and the REEP5 gene...
  6. Min K, Davila S, Zealy R, Lloyd L, Lee I, Lee R, et al. eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation. Biochim Biophys Acta Gene Regul Mech. 2017;1860:761-772 pubmed publisher triggered by TNF-?-induced and MST1-mediated eIF4E phosphorylation, which exhibits molecular mimicry of SRP19 and, thus, competes for 7SL RNA...
  7. Zhang Q, Ma J, Liu H, He D, Chen L, Wu H, et al. Comparative Analysis of Gene Expression Profiles of Human Dental Fluorosis and Kashin-Beck Disease. Sci Rep. 2018;8:170 pubmed publisher
    ..A total of 10 overlaps (DUSP2, KLRF1, SRP19, KLRC3, CD69, SIK1, ITGA4, ID3, HSPA1A, GPR18) were obtained between DEGs of patients with KBD and patients with ..
  8. Plagens A, Daume M, Wiegel J, Randau L. Circularization restores signal recognition particle RNA functionality in Thermoproteus. elife. 2015;4: pubmed publisher
    ..Canonical SRP RNA genes have not been identified for some Thermoproteus species even though they contain SRP19 and SRP54 proteins...
  9. Gowda K, Chittenden K, Zwieb C. Binding site of the M-domain of human protein SRP54 determined by systematic site-directed mutagenesis of signal recognition particle RNA. Nucleic Acids Res. 1997;25:388-94 pubmed
    ..Binding of protein SRP19 was diminished significantly by mutations in helix 6 and was stringently required for SRP54M to associate...

More Information


  1. Groden J, Thliveris A, Samowitz W, Carlson M, Gelbert L, Albertsen H, et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell. 1991;66:589-600 pubmed
    ..DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for mutations in three genes (DP1, SRP19, and DP2.5) located within a 100 kb region deleted in two of the patients...
  2. Wang T, Tian C, Zhang W, Luo K, Sarkis P, Yu L, et al. 7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G. J Virol. 2007;81:13112-24 pubmed
    ..Reducing 7SL RNA packaging by overexpression of SRP19 proteins inhibited 7SL RNA and A3G virion packaging and impaired its antiviral function...
  3. Becker M, Lapouge K, Segnitz B, Wild K, Sinning I. Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction. Nucleic Acids Res. 2017;45:470-481 pubmed publisher
    ..protein-binding domain (PBD) in complex with SRP72-PBD and of the SRP72-RBD bound to the SRP S domain (SRP RNA, SRP19 and SRP68) detailing all interactions of SRP72 within SRP...
  4. Wang Q, Duan F, Liu P, Wang P, Wang M. Expression of anti-SRP19 antibody in muscle tissues from patients with autoimmune necrotizing myopathy. Genet Mol Res. 2016;15: pubmed publisher
    This study aimed to investigate the role of anti-SRP19 antibody in muscle tissues of patients with autoimmune necrotizing myopathy...
  5. Grotwinkel J, Wild K, Segnitz B, Sinning I. SRP RNA remodeling by SRP68 explains its role in protein translocation. Science. 2014;344:101-4 pubmed publisher
    ..the crystal structures of the RNA-binding domain of SRP68 (SRP68-RBD) alone and in complex with SRP RNA and SRP19. SRP68-RBD is a tetratricopeptide-like module that binds to a RNA three-way junction, bends the RNA, and inserts ..
  6. Piazzon N, Schlotter F, Lefebvre S, Dodré M, Mereau A, Soret J, et al. Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle. Nucleic Acids Res. 2013;41:1255-72 pubmed publisher
    ..Our data show that reduced levels of the SMN protein lead to defect in SRP steady-state level and describe the SMN complex as the first identified cellular factor required for SRP biogenesis. ..
  7. Wild K, Bange G, Bozkurt G, Segnitz B, Hendricks A, Sinning I. Structural insights into the assembly of the human and archaeal signal recognition particles. Acta Crystallogr D Biol Crystallogr. 2010;66:295-303 pubmed publisher
    ..The two helices are juxtaposed and clamped together upon binding of the SRP19 protein to their apices...
  8. Yoshida M, Kabe Y, Wada T, Asai A, Handa H. A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Mol Pharmacol. 2008;73:987-94 pubmed
    ..The results revealed that TAS-103 disrupts SRP complex formation and reduces the amount of SRP14 and SRP19. TAS-103 treatment and RNAi-mediated knockdown of SRP54 or SRP14 promoted accumulation of the exogenously ..
  9. Maity T, Weeks K. A threefold RNA-protein interface in the signal recognition particle gates native complex assembly. J Mol Biol. 2007;369:512-24 pubmed
    ..The SRP19 protein is unstructured but forms a compact core domain and two extended RNA-binding loops upon binding the signal ..
  10. Volik S, Raphael B, Huang G, Stratton M, Bignel G, Murnane J, et al. Decoding the fine-scale structure of a breast cancer genome and transcriptome. Genome Res. 2006;16:394-404 pubmed
    ..Given these properties, ESP could play an important role in a tumor genome project. ..
  11. Dean K, von Ahsen O, Gorlich D, Fried H. Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. J Cell Sci. 2001;114:3479-85 pubmed
    ..Here we show that the 19 kDa protein subunit of mammalian SRP, SRP19, was efficiently imported into the nucleus in vitro by two members of the importin beta superfamily of transport ..
  12. Lingelbach K, Zwieb C, Webb J, Marshallsay C, Hoben P, Walter P, et al. Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. Nucleic Acids Res. 1988;16:9431-42 pubmed
    ..We have isolated and characterized cDNA clones from human liver which encode the 19kDa protein subunit (SRP19)...
  13. Joslyn G, Carlson M, Thliveris A, Albertsen H, Gelbert L, Samowitz W, et al. Identification of deletion mutations and three new genes at the familial polyposis locus. Cell. 1991;66:601-13 pubmed
    ..One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle...