SRGAP3

Summary

Gene Symbol: SRGAP3
Description: SLIT-ROBO Rho GTPase activating protein 3
Alias: ARHGAP14, MEGAP, SRGAP2, WRP, SLIT-ROBO Rho GTPase-activating protein 3, SLIT-ROBO Rho GTPase activating protein 2, WAVE-associated Rac GTPase activating protein, mental disorder-associated GAP, rho GTPase-activating protein 14
Species: human
Products:     SRGAP3

Top Publications

  1. Mole R, Good C, Stebel E, Higgins J, Pitell S, Welch A, et al. Correlating effluent concentrations and bench-scale experiments to assess the transformation of endocrine active compounds in wastewater by UV or chlorination disinfection. Chemosphere. 2019;226:565-575 pubmed publisher
    ..testing assessed concentration of 13 EACs in effluent at two Chicago area 250 MGD wastewater reclamation plants (WRP) over two years. One WRP uses chlorination/dechlorination while the other employs UV disinfection...
  2. Eszlari N, Millinghoffer A, Petschner P, Gonda X, Baksa D, Pulay A, et al. Genome-wide association analysis reveals KCTD12 and miR-383-binding genes in the background of rumination. Transl Psychiatry. 2019;9:119 pubmed publisher
    ..results and their links to brain expression levels based on external databases supported the role of KCTD12, SRGAP3, and SETD5 in rumination, CDH12 in brooding, and DPYSL5, MAPRE3, KCNK3, ATXN7L3B, and TPH2 in reflection, among ..
  3. de Kock C, Noben C, Lagro Janssen A, Lucassen P, Knottnerus A, de Rijk A, et al. Affecting patients with work-related problems by educational training of their GPs: a cost-effectiveness study. BMC Fam Pract. 2019;20:38 pubmed publisher
    ..aimed at increasing GPs' work awareness and more proactive counseling for patients with work-related problems (WRP)...
  4. Sun M, Wu D, Zhou K, Li H, Gong X, Wei Q, et al. An eight-lncRNA signature predicts survival of breast cancer patients: a comprehensive study based on weighted gene co-expression network analysis and competing endogenous RNA network. Breast Cancer Res Treat. 2019;: pubmed publisher
    ..065 × EXPWT1-AS) + (- 0.126 × EXPADAMTS9-AS1) + (- 0.130 × EXPSRGAP3-AS2) + (0.116 × EXPTLR8-AS1) + (0.060 × EXPHOTAIR) with median score 1.088...
  5. Spence E, Dube S, Uezu A, Locke M, Soderblom E, Soderling S. In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation. Nat Commun. 2019;10:386 pubmed publisher
    ..uncharacterized protein, CARMIL3, which interacts in vivo with the synaptic cytoskeletal regulator proteins SrGAP3 (or WRP) and actin capping protein...
  6. Ho N, Kutzner A, Heese K. A Novel Divergent Gene Transcription Paradigm-the Decisive, Brain-Specific, Neural |-Srgap2-Fam72a-| Master Gene Paradigm. Mol Neurobiol. 2019;: pubmed publisher
    Brain development and repair largely depend on neural stem cells (NSCs). Here, we suggest that two genes, i.e., Srgap2 (SLIT-ROBO Rho GTPase-activating protein 2) and Fam72a (family with sequence similarity to 72, member A), constitute a ..
  7. Cao Y, Kwok B, Van Loosdrecht M, Daigger G, Png H, Long W, et al. The influence of dissolved oxygen on partial nitritation/anammox performance and microbial community of the 200,000 m3/d activated sludge process at the Changi water reclamation plant (2011 to 2016). Water Sci Technol. 2018;78:634-643 pubmed publisher
    ..in a 200,000 m3/d step-feed activated sludge process (Train 2) in the Changi Water Reclamation Plant (WRP), Singapore, has been studied and reported...
  8. Surakka I, Whitfield J, Perola M, Visscher P, Montgomery G, Falchi M, et al. A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol. Twin Res Hum Genet. 2012;15:691-9 pubmed publisher
    ..locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors(P=3.98 x 10-8)...
  9. Obilor H, Adejumo P, Ilesanmi R. Assessment of patients' wound-related pain experiences in University College Hospital, Ibadan, Nigeria. Int Wound J. 2016;13:697-704 pubmed publisher
    This study was necessitated by the international recognition of wound-related pain (WRP) as a must-address issue and patient-centred concerns...

More Information

Publications67

  1. Carlson B, Lloyd K, Kruszewski A, Kim I, Rodriguiz R, Heindel C, et al. WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory. J Neurosci. 2011;31:2447-60 pubmed publisher
    The WAVE-associated Rac GAP, WRP, is thought to regulate key aspects of synapse development and function and may be linked to mental retardation in humans. WRP contains a newly described inverse F-BAR (IF-BAR) domain of unknown function...
  2. Ramasamy M, Power C, Mkandawire M. Numerical prediction of the long-term evolution of acid mine drainage at a waste rock pile site remediated with an HDPE-lined cover system. J Contam Hydrol. 2018;216:10-26 pubmed publisher
    ..to assess the long-term effectiveness of an 'in-service' HDPE-lined cover system for reducing AMD contamination at WRP sites...
  3. Tyler Smith C, Xue Y. Sibling rivalry among paralogs promotes evolution of the human brain. Cell. 2012;149:737-9 pubmed publisher
    ..Two papers in this issue suggest that partial duplication of SRGAP2, producing an incomplete protein that antagonizes the original, contributed to human brain evolution.
  4. Purnell S, Ebdon J, Buck A, Tupper M, Taylor H. Bacteriophage removal in a full-scale membrane bioreactor (MBR) - Implications for wastewater reuse. Water Res. 2015;73:109-17 pubmed publisher
    ..were taken each week for three months from nine locations at each treatment stage of the water recycling plant (WRP) and tested for a range of microbiological parameters (n = 135). Mean levels of faecal coliforms were reduced to 0...
  5. Sylvain C, Durand M, Velasquez Sanchez A, Lessard N, Maillette P. Development and Implementation of a Mental Health Work Rehabilitation Program: Results of a Developmental Evaluation. J Occup Rehabil. 2018;: pubmed publisher
    ..aimed to support and evaluate, in real time, the development and implementation of a work rehabilitation program (WRP) designed to promote post-CMD return-to-work (RTW)...
  6. Vucićević J, Popovic M, Nikolic K, Filipic S, Obradovic D, Agbaba D. Use of biopartitioning micellar chromatography and RP-HPLC for the determination of blood-brain barrier penetration of ?-adrenergic/imidazoline receptor ligands, and QSPR analysis. SAR QSAR Environ Res. 2017;28:235-252 pubmed publisher
    ..using biopartitioning micellar and classical reversed phase chromatography (log kBMC and log kwRP, respectively)...
  7. Fossati M, Pizzarelli R, Schmidt E, Kupferman J, Stroebel D, Polleux F, et al. SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses. Neuron. 2016;91:356-69 pubmed publisher
    ..mechanism coordinating critical features of synaptic development and suggest that human-specific duplication of SRGAP2 might have contributed to the emergence of unique traits of human neurons while preserving the excitation/..
  8. Zhang Q, Zhang H, Zhang X, Zhao J, Ma Z, Zhao D, et al. srGAP3 promotes neurite outgrowth of dorsal root ganglion neurons by inactivating RAC1. Asian Pac J Trop Med. 2014;7:630-638 pubmed publisher
    To explore effect of srGAP3 promotes neurite outgrowth of dorsal root ganglion neurons...
  9. Koschützke L, Bertram J, Hartmann B, Bartsch D, Lotze M, Von Bohlen Und Halbach O. SrGAP3 knockout mice display enlarged lateral ventricles and specific cilia disturbances of ependymal cells in the third ventricle. Cell Tissue Res. 2015;361:645-50 pubmed publisher
    In several mouse models of mental retardation, ventricular enlargements have been observed. Mutation in the SrGAP3 gene residing on chromosome 3p25 has previously been associated with intellectual disability in humans...
  10. Gao J, Ma Y, Fu H, Luo Q, Wang Z, Xiao Y, et al. Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells. Protein Cell. 2016;7:351-61 pubmed publisher
    ..Our previous studies have demonstrated that srGAP3 can negatively regulate neuronal differentiation of Neuro2a cells...
  11. Guez Haddad J, Sporny M, Sasson Y, Gevorkyan Airapetov L, Lahav Mankovski N, Margulies D, et al. The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand Binding through a Two-Component Molecular Mechanism. Structure. 2015;23:1989-2000 pubmed publisher
    ..Here, we report a two-component molecular mechanism that regulates ligand binding to srGAP2 by on the one hand dramatically tightening their association and on the other, moderately autoinhibiting and ..
  12. Bertram J, Koschützke L, Pfannmöller J, Esche J, van Diepen L, Kuss A, et al. Morphological and behavioral characterization of adult mice deficient for SrGAP3. Cell Tissue Res. 2016;366:1-11 pubmed publisher
    b>SrGAP3 belongs to the family of Rho GTPase proteins. These proteins are thought to play essential roles in development and in the plasticity of the nervous system...
  13. Guleryuz G, Erdemir U, Arslan H, Gucer S. Elemental composition of Marrubium astracanicum Jacq. growing in tungsten-contaminated sites. Environ Sci Pollut Res Int. 2016;23:18332-42 pubmed publisher
    ..The other site was selected from a waste removal pool (WRP) and was assumed to be a polluted site...
  14. Larinkari S, Liisanantti J, Ala Lääkkölä T, Meriläinen M, Kyngäs H, Ala Kokko T. Identification of tele-ICU system requirements using a content validity assessment. Int J Med Inform. 2016;86:30-6 pubmed publisher
    ..75 threshold were considered relevant. Weighted ranking points (WRP) was calculated from the ranking data...
  15. Chung S, Rho S, Kim G, Kim S, Baek K, Kang M, et al. Human umbilical cord blood mononuclear cells and chorionic plate-derived mesenchymal stem cells promote axon survival in a rat model of optic nerve crush injury. Int J Mol Med. 2016;37:1170-80 pubmed publisher
    ..ERM-like protein (ERMN) and SLIT-ROBO Rho GTPase activating protein 2 (SRGAP2) were found to be expressed in the optic nerves of the CP?MSC-injected rats with ONC injury...
  16. Stroman D, Kreuter U. Landowner Satisfaction with the Wetland Reserve Program in Texas: A Mixed-Methods Analysis. Environ Manage. 2016;57:97-108 pubmed publisher
    ..This study found that landowners were dissatisfied with the NRCS Wetland Reserve Program (WRP), conflicting with results of previous studies...
  17. Fritz R, Menshykau D, Martin K, Reimann A, Pontelli V, Pertz O. SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion. Dev Cell. 2015;35:78-92 pubmed publisher
    ..We identify the Slit2-Robo4-srGAP2 signaling network as a key regulator of CIL in fibroblasts...
  18. Cao Y, Kwok B, Van Loosdrecht M, Daigger G, Png H, Long W, et al. The occurrence of enhanced biological phosphorus removal in a 200,000 m3/day partial nitration and Anammox activated sludge process at the Changi water reclamation plant, Singapore. Water Sci Technol. 2017;75:741-751 pubmed publisher
    ..has been observed and studied in the step-feed activated sludge process at the Changi water reclamation plant (WRP), which is the largest WRP (800,000 m3/d) in Singapore...
  19. Tran N, Gin K. Occurrence and removal of pharmaceuticals, hormones, personal care products, and endocrine disrupters in a full-scale water reclamation plant. Sci Total Environ. 2017;599-600:1503-1516 pubmed publisher
    ..occurrence and removal of twenty-five target emerging contaminants (ECs) in a full-scale water reclamation plant (WRP) in the Southeast Asian region...
  20. Marko T, Shamsan G, Edwards E, Hazelton P, Rathe S, Cornax I, et al. Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma. Sci Rep. 2016;6:39059 pubmed publisher
    ..identified potential genetic drivers of osteosarcoma metastasis, including Slit-Robo GTPase-Activating Protein 2 (Srgap2)...
  21. Yang Q, Shen N, Lee Z, Xu G, Cao Y, Kwok B, et al. Simultaneous nitrification, denitrification and phosphorus removal (SNDPR) in a full-scale water reclamation plant located in warm climate. Water Sci Technol. 2016;74:448-56 pubmed publisher
    ..This study analyzed the nutrients (N and P) profiles in a full-scale municipal wastewater reclamation plant (WRP) located in the tropical region, in which more than 90% of nitrogen was removed...
  22. Power C, Ramasamy M, Mkandawire M. Performance assessment of a single-layer moisture store-and-release cover system at a mine waste rock pile in a seasonally humid region (Nova Scotia, Canada). Environ Monit Assess. 2018;190:186 pubmed publisher
    ..This cover type was installed at a WRP in Nova Scotia, Canada, alongside state-of-the-art monitoring instrumentation...
  23. Kutzner A, Pramanik S, Kim P, Heese K. All-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci. Genomics. 2015;106:278-85 pubmed publisher
    ..segmental gene duplications are most likely to have occurred in conjunction with the paired genomic neighbour SRGAP2 (SLIT-ROBO Rho GTPase activating protein), as both genes have four paralogues in humans but only one vertebra-..
  24. Tran N, Gan J, Nguyen V, Chen H, You L, Duarah A, et al. Sorption and biodegradation of artificial sweeteners in activated sludge processes. Bioresour Technol. 2015;197:329-38 pubmed publisher
    ..This study investigated the fate of ASs in both the aqueous and solid phases in a water reclamation plant (WRP). All the four targeted ASs, i.e...
  25. Sporny M, Guez Haddad J, Waterman D, Isupov M, Opatowsky Y. Molecular symmetry-constrained systematic search approach to structure solution of the coiled-coil SRGAP2 F-BARx domain. Acta Crystallogr D Struct Biol. 2016;72:1241-1253 pubmed
    b>SRGAP2 (Slit-Robo GTPase-activating protein 2) is a cytoplasmic protein found to be involved in neuronal branching, restriction of neuronal migration and restriction of the length and density of dendritic postsynaptic spines...
  26. Jiao Q, Wang L, Zhang Z, Wang Y, Yan H, Ma W, et al. Dynamic expression of srGAP2 in cell nuclei and cytoplasm during the differentiation of rat neural stem cells in vitro. Mol Med Rep. 2016;14:4599-4605 pubmed publisher
    ..Although srGAP2 is expressed in developmental brain tissue, little is known about its influence on cellular development of the ..
  27. Lenihan J, Saha O, Heimer McGinn V, Cryan J, Feng G, Young P. Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Mol Neurobiol. 2017;54:8090-8109 pubmed publisher
    ..ERC2 and LIPRIN-?s (PPFIA1, PPFIA3), as well as the F-BAR domain proteins FCHSD2 (nervous wreck homologue) and SRGAP2. These and other novel LNX-interacting proteins identified are promising candidates to mediate LNX functions in ..
  28. Wang F, Lin C, Lien S, Wu L, Huang C, Chu D. Sex difference determined the role of sex hormone-binding globulin in obese children during short-term weight reduction program. Medicine (Baltimore). 2017;96:e6834 pubmed publisher
    ..between the changes in insulin resistance indices and serum SHBG concentration during weight reduction program (WRP) is not fully understood, particularly in obese children...
  29. Ho N, Kim P, Kutzner A, Heese K. Cognitive Functions: Human vs. Animal - 4:1 Advantage |-FAM72-SRGAP2-|. J Mol Neurosci. 2017;61:603-606 pubmed publisher
    ..heidelbergensis, H. neanderthalensis, H. erectus, and the Denisovans). Here, we suggest that the |-FAM72-SRGAP2-| (family with sequence similarity 72/SLIT-ROBO Rho GTPase activating protein 2) gene pair is a unique molecular ..
  30. Liu Q, Wang X, Liu Y, Wei M, Chen L. A combinative analysis of gene expression profiles and microRNA expression profiles identifies critical genes and microRNAs in oral lichen planus. Arch Oral Biol. 2016;68:61-5 pubmed publisher
    ..Four targets of miR-362 were SLIT-ROBO Rho GTPase activating protein 2 (SRGAP2), vesicle-associated membrane protein 4 (VAMP4), leucine rich repeat transmembrane neuronal 4 (LRRTM4) and lysine (..
  31. de Kock C, Lucassen P, Spinnewijn L, Knottnerus J, Buijs P, Steenbeek R, et al. How do Dutch GPs address work-related problems? A focus group study. Eur J Gen Pract. 2016;22:169-75 pubmed publisher
    ..general practitioners' (GPs) perception of their role regarding patients' occupation and work related problems (WRP)...
  32. Li M, Quan C, Toth R, Campbell D, MacKintosh C, Wang H, et al. Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders. J Biol Chem. 2015;290:30030-41 pubmed publisher
    ..residues on brain proteins including cytoskeletal regulators such as slit-robo GTPase-activating protein 3 (srGAP3) and microtubule affinity-regulating protein kinases (MARKs), in which deficiency or dysregulation is linked to ..
  33. Zhu J, Anderson P. Exploring aeration-associated energy savings at a conventional water reclamation plant. Water Sci Technol. 2017;76:2222-2231 pubmed publisher
    ..to evaluate possible aeration savings at the Metropolitan Water Reclamation District of Greater Chicago Calumet WRP, one of the oldest plants in Chicago...
  34. Wuertenberger S, Groemping Y. A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains. FEBS Lett. 2015;589:1156-63 pubmed publisher
    The Slit-Robo GTPase-activating protein 3 (srGAP3) has been implicated in different critical aspects of neuronal development...
  35. Lucas B, Hardin J. Mind the (sr)GAP - roles of Slit-Robo GAPs in neurons, brains and beyond. J Cell Sci. 2017;130:3965-3974 pubmed publisher
    ..Gene duplication of the human-specific paralog of srGAP2 has resulted in srGAP2 family proteins that may have increased the density of dendritic spines and promoted ..
  36. Yang Y, Marcello M, Endris V, Saffrich R, Fischer R, Trendelenburg M, et al. MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation. Exp Cell Res. 2006;312:2379-93 pubmed
    ..We have analysed the role of MEGAP, a GTPase-activating protein that acts towards Rac1 and Cdc42 in vitro and in vivo, with respect to its putative ..
  37. Elstner M, Morris C, Heim K, Lichtner P, Bender A, Mehta D, et al. Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene. Ann Neurol. 2009;66:792-8 pubmed publisher
    ..14 x 10(-7)), PDXK (vitamin B6/dopamine metabolism, p = 3.27 x 10(-6)), SRGAP3 (axon guidance, p = 5.65 x 10(-6)), and TRAPPC4 (vesicle transport, p = 5.81 x 10(-6))...
  38. Jain P, Fierst T, Han H, Smith T, Vakil A, Storm P, et al. CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles. Oncogene. 2017;36:6348-6358 pubmed publisher
    ..Whereas BRAF fusions primarily dysregulate MAPK signaling, the CRAF fusions QKI-RAF1 and SRGAP3-RAF1 aberrantly activate both the MAPK and phosphoinositide-3 kinase/mammalian target of rapamycin (PI3K/mTOR) ..
  39. Yang Y, Xiong X, Liu J, Wu L, Zhong Q, Zhou K, et al. Mfsd2a (Major Facilitator Superfamily Domain Containing 2a) Attenuates Intracerebral Hemorrhage-Induced Blood-Brain Barrier Disruption by Inhibiting Vesicular Transcytosis. J Am Heart Assoc. 2017;6: pubmed publisher
    ..Finally, using multiple reaction monitoring, we screened out 3 vesicle trafficking-related proteins (Srgap2, Stx7, and Sec22b) from 31 vesicle trafficking-related proteins that were markedly upregulated in Mfsd2a knockout ..
  40. Zhu J, Anderson P. Effect of long-term successive storm flows on water reclamation plant resilience. Water Res. 2017;111:1-9 pubmed publisher
    A water reclamation plant (WRP) needs to be resilient to successfully operate through different kinds of perturbations. Perturbations such as storm events, especially long-term successive storm flows, can adversely affect operations...
  41. Shuib S, McMullan D, Rattenberry E, Barber R, Rahman F, Zatyka M, et al. Microarray based analysis of 3p25-p26 deletions (3p- syndrome). Am J Med Genet A. 2009;149A:2099-105 pubmed publisher
    ..kb and a candidate critical region for mental retardation was mapped to an approximately 1 Mb interval containing SRGAP3 but other 3p neurodevelopmental genes including CHL1, CNTN4, LRRN1, and ITPR1 mapped outside the candidate ..
  42. Power C, Ramasamy M, Macaskill D, Shea J, MacPhee J, Mayich D, et al. Five-year performance monitoring of a high-density polyethylene (HDPE) cover system at a reclaimed mine waste rock pile in the Sydney Coalfield (Nova Scotia, Canada). Environ Sci Pollut Res Int. 2017;24:26744-26762 pubmed publisher
    ..In 2011, a HDPE cover was installed over the Scotchtown Summit WRP in Nova Scotia, Canada, and extensive field performance monitoring was conducted over the next five years...
  43. Wong K, Ren X, Huang Y, Xie Y, Liu G, Saito H, et al. Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell. 2001;107:209-21 pubmed
    ..These results have demonstrated important roles for GAPs and Cdc42 in neuronal migration. We propose a signal transduction pathway from the extracellular guidance cue to intracellular actin polymerization. ..
  44. Endris V, Wogatzky B, Leimer U, Bartsch D, Zatyka M, Latif F, et al. The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation. Proc Natl Acad Sci U S A. 2002;99:11754-9 pubmed
    ..MEGAP/srGAP3 mRNA is predominantly and highly expressed in fetal and adult brain, specifically in the neurons of the ..
  45. Lahoz A, Hall A. A tumor suppressor role for srGAP3 in mammary epithelial cells. Oncogene. 2013;32:4854-60 pubmed publisher
    b>srGAP3, a member of the Slit-Robo sub-family of Rho GTPase-activating proteins (Rho GAPs), controls actin and microtubule dynamics through negative regulation of Rac...
  46. Dai Y, Ma Y, Chen K, Mi Y, Fu H, Cui D, et al. A link between the nuclear-localized srGAP3 and the SWI/SNF chromatin remodeler Brg1. Mol Cell Neurosci. 2014;60:10-25 pubmed publisher
    The Slit-Robo GTPase activating protein 3 (srGAP3) is an important modulator of actin cytoskeletal dynamics and has an important influence on a variety of neurodevelopmental processes...
  47. Zeng S, Huang Y, Sun F, Li D, He M. Probabilistic ecological risk assessment of effluent toxicity of a wastewater reclamation plant based on process modeling. Water Res. 2016;100:367-376 pubmed publisher
    ..This study applied a system analysis approach, regarding a wastewater reclamation plant (WRP) and its recipient water body as a whole system, and assessed the ecological risk of the recipient water body ..
  48. Ho N, Kutzner A, Heese K. Brain plasticity, cognitive functions and neural stem cells: a pivotal role for the brain-specific neural master gene |-SRGAP2-FAM72-|. Biol Chem. 2017;399:55-61 pubmed publisher
    ..Here, we suggest that the novel master gene pair |-SRGAP2-FAM72-| (SLIT-ROBO Rho GTPase activating the protein 2, family with sequence similarity to 72) reveals a new dogma ..
  49. Zhu J, Kang L, Anderson P. Predicting influent biochemical oxygen demand: Balancing energy demand and risk management. Water Res. 2018;128:304-313 pubmed publisher
    Ready access to comprehensive influent information can help water reclamation plant (WRP) operators implement better real-time process controls, provide operational reliability and reduce energy consumption...
  50. Fleury M, Grenier G, Bamvita J, Chiocchio F. Variables Associated With Perceived Work Role Performance Among Professionals in Multidisciplinary Mental Health Teams Overall and in Primary Care and Specialized Service Teams, Respectively. Eval Health Prof. 2017;:163278717734282 pubmed publisher
    This study had a dual purpose (1) to identify variables associated with perceived work role performance (WRP) among 315 mental health professionals (MHPs) in Quebec and (2) to compare variables related to WRP in MH primary care teams (..
  51. Ellery P, Ellis R, Holder S. Interstitial 3p25 deletion in a patient with features of 3p deletion syndrome: further evidence for the role of SRGAP3 in mental retardation. Clin Dysmorphol. 2014;23:29-31 pubmed publisher
  52. Olave I, Wang W, Xue Y, Kuo A, Crabtree G. Identification of a polymorphic, neuron-specific chromatin remodeling complex. Genes Dev. 2002;16:2509-17 pubmed
    ..We speculate that bBAF complexes create neuronal-specific patterns of chromatin accessibility, thereby imparting new regulatory characteristics to ubiquitous sequence-specific transcription factors in neurons. ..
  53. Miguel M, Barreto R, Pereira S. Study of a tropical soil in order to use it to retain aluminum, iron, manganese and fluoride from acid mine drainage. J Environ Manage. 2017;204:563-570 pubmed publisher
    ..Waste rock pile 4 (WRP-4) generates acid mine drainage (AMD), which is discharged in the Nestor Figueiredo retention pond (NFP)...
  54. Miao L, Yin R, Wu J, Yang S, Lin W, Pan S. The SRGAP2 SNPs, their haplotypes and G × E interactions on serum lipid traits. Sci Rep. 2017;7:11626 pubmed publisher
    ..Little is known about the association of the Slit-Robo Rho GTPase activating protein 2 gene (SRGAP2) single nucleotide polymorphisms (SNPs) and serum lipid levels in the Chinese populations...
  55. Katoh M, Katoh M. FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains. Int J Mol Med. 2003;11:791-7 pubmed
    ..1. FNBP2 mRNA was expressed in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma. ARHGAP13/SRGAP1, ARHGAP14/SRGAP2 and ARHGAP4 cDNAs were homologous to FNBP2/KIAA0456 cDNA...
  56. Hamdan F, Gauthier J, Pellerin S, Dobrzeniecka S, Marineau C, Fombonne E, et al. No association between SRGAP3/MEGAP haploinsufficiency and mental retardation. Arch Neurol. 2009;66:675-6 pubmed publisher
  57. Soderling S, Binns K, Wayman G, Davee S, Ong S, Pawson T, et al. The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol. 2002;4:970-5 pubmed
    ..used tandem mass spectrometry to identify previously unknown components of the WAVE signalling network including WRP, a Rac-selective GTPase-activating protein...
  58. Pan Y, Jiang S, Hou Q, Qiu D, Shi J, Wang L, et al. Dissection of Glomerular Transcriptional Profile in Patients With Diabetic Nephropathy: SRGAP2a Protects Podocyte Structure and Function. Diabetes. 2018;67:717-730 pubmed publisher
    ..protective role of SRGAP2a in podocyte function also is confirmed in zebrafish, in which knockdown of SRGAP2a, a SRGAP2 ortholog in zebrafish, recapitulates podocyte foot process effacement...