SRF

Summary

Gene Symbol: SRF
Description: serum response factor
Alias: MCM1, serum response factor, c-fos serum response element-binding transcription factor, minichromosome maintenance 1 homolog
Species: human
Products:     SRF

Top Publications

  1. Wang Z, Wang D, Hockemeyer D, McAnally J, Nordheim A, Olson E. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature. 2004;428:185-9 pubmed
    ..b>Serum response factor (SRF) activates genes involved in smooth muscle differentiation and proliferation by recruiting muscle-..
  2. Chen C, Schwartz R. Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription. Mol Cell Biol. 1996;16:6372-84 pubmed
    ..5 served as a positive acting accessory factor for serum response factor (SRF) and that together they provided strong transcriptional activation of the cardiac alpha-actin ..
  3. Ding W, Gao S, Scott R. Senescence represses the nuclear localization of the serum response factor and differentiation regulates its nuclear localization with lineage specificity. J Cell Sci. 2001;114:1011-8 pubmed
    ..cells into adipocytes represses growth factor responsiveness by limiting the nuclear localization of the serum response factor (SRF) that binds to and activates the promoters of growth control genes that contain the serum response ..
  4. Wang D, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, et al. Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci U S A. 2002;99:14855-60 pubmed
    Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associates with serum response factor (SRF) to potently enhance SRF-dependent transcription...
  5. Miano J. Serum response factor: toggling between disparate programs of gene expression. J Mol Cell Cardiol. 2003;35:577-93 pubmed
    b>Serum response factor (SRF) is a widely expressed transcription factor involved in orchestrating disparate programs of gene expression linked to muscle differentiation and cellular growth...
  6. Selvaraj A, Prywes R. Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation. J Biol Chem. 2003;278:41977-87 pubmed
    b>Serum response factor (SRF) is required for the expression of a wide variety of muscle-specific genes that are expressed upon differentiation and is thus required for both striated and smooth muscle differentiation in addition to its ..
  7. Chai J, Jones M, Tarnawski A. Serum response factor is a critical requirement for VEGF signaling in endothelial cells and VEGF-induced angiogenesis. FASEB J. 2004;18:1264-6 pubmed
    ..b>Serum response factor (SRF) is a transcription factor important for embryonic development and activation of immediate early gene ..
  8. Azhar G, Zhang X, Wang S, Zhong Y, Quick C, Wei J. Maintaining serum response factor activity in the older heart equal to that of the young adult is associated with better cardiac response to isoproterenol stress. Basic Res Cardiol. 2007;102:233-44 pubmed
    ..the effect of transcription regulation in modulating cardiac aging, we sought to study the role of serum response factor (SRF), a key transcription factor in the heart that is normally increased with senescence and also in ..
  9. Muehlich S, Wang R, Lee S, Lewis T, Dai C, Prywes R. Serum-induced phosphorylation of the serum response factor coactivator MKL1 by the extracellular signal-regulated kinase 1/2 pathway inhibits its nuclear localization. Mol Cell Biol. 2008;28:6302-13 pubmed publisher
    Megakaryoblastic leukemia 1 (MKL1) is a myocardin-related coactivator of the serum response factor (SRF) transcription factor, which has an integral role in differentiation, migration, and proliferation...

More Information

Publications116 found, 100 shown here

  1. Kwon C, Kim K, Choi H, Chung M, Noh S, Kim D, et al. The role of serum response factor in hepatocellular carcinoma: implications for disease progression. Int J Oncol. 2010;37:837-44 pubmed
    b>Serum response factor (SRF) regulates transcription of the immediate early genes and triggers proliferation, migration and differentiation in several types of cells...
  2. Kim K, Bae J, Choi H, Park H, Jang K, Chung M, et al. The role of serum response factor in hepatocellular carcinoma: an association with matrix metalloproteinase. Oncol Rep. 2011;26:1567-72 pubmed publisher
    b>Serum response factor (SRF) regulates tran-scription of immediate early genes and triggers proliferation, migration and differentiation in several types of cells...
  3. Shore P, Sharrocks A. The MADS-box family of transcription factors. Eur J Biochem. 1995;229:1-13 pubmed
    ..within the DNA-binding domains of these proteins and the name refers to four of the originally identified members: MCM1, AG, DEFA and SRF. Several proteins within this family have significant biological roles...
  4. Groisman R, Masutani H, Leibovitch M, Robin P, Soudant I, Trouche D, et al. Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins. J Biol Chem. 1996;271:5258-64 pubmed
    ..On the other hand, the serum response factor (SRF) is involved in the activation of muscle-specific genes, such as c-fos, as well as in the up-..
  5. Biesiada E, Hamamori Y, Kedes L, Sartorelli V. Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter. Mol Cell Biol. 1999;19:2577-84 pubmed
    ..alpha-actin (HCA) promoter in skeletal muscle cells requires the integrity of DNA binding sites for the serum response factor (SRF), Sp1, and the myogenic basic helix-loop-helix (bHLH) family...
  6. Wang D, Chang P, Wang Z, Sutherland L, Richardson J, Small E, et al. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell. 2001;105:851-62 pubmed
    b>Serum response factor (SRF) regulates transcription of numerous muscle and growth factor-inducible genes. Because SRF is not muscle specific, it has been postulated to activate muscle genes by recruiting myogenic accessory factors...
  7. Vickers E, Kasza A, Kurnaz I, Seifert A, Zeef L, O Donnell A, et al. Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death. Mol Cell Biol. 2004;24:10340-51 pubmed
    ..elements (SREs) in the promoters of target genes in a ternary complex with a second transcription factor, serum response factor (SRF)...
  8. Doi H, Iso T, Yamazaki M, Akiyama H, Kanai H, Sato H, et al. HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box. Arterioscler Thromb Vasc Biol. 2005;25:2328-34 pubmed
    Myocardin is a coactivator of serum response factor (SRF) required for vascular smooth muscle cell (VSMC) differentiation...
  9. Chow N, Bell R, Deane R, Streb J, Chen J, Brooks A, et al. Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc Natl Acad Sci U S A. 2007;104:823-8 pubmed
    ..small pial and intracerebral arteries, which are critical for CBF regulation, express in AD high levels of serum response factor (SRF) and myocardin (MYOCD), two interacting transcription factors that orchestrate a VSMC-differentiated ..
  10. Medjkane S, Perez Sanchez C, Gaggioli C, Sahai E, Treisman R. Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat Cell Biol. 2009;11:257-68 pubmed publisher
    ..activation through myocardin-related transcription factors (MRTFs), which are co-activators for serum response factor (SRF)...
  11. Malaney P, Palumbo E, Semidey Hurtado J, Hardee J, Stanford K, Kathiriya J, et al. PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer. Cell Cycle. 2018;17:947-962 pubmed publisher
    ..Recombinase Rad52 RAD52 Recombinase RPA1 Replication protein A SILAC Stable Isotope Labeling with Amino Acids in Cell Culture SRF Serum Response Factor TKI Tyrosine Kinase inhbitors TMA Tissue Microarray TOP2A DNA Topoisomerase 2A.
  12. Hudson C, McArdle C, López Bernal A. Steroid receptor co-activator interacting protein (SIP) mediates EGF-stimulated expression of the prostaglandin synthase COX2 and prostaglandin release in human myometrium. Mol Hum Reprod. 2016;22:512-25 pubmed publisher
    ..05), and SIP expression was positively associated with activation of serum response factor (SRF) and YY1 TF (P < 0.001 and P < 0...
  13. Huang J, Wang T, Wright A, Yang J, Zhou S, Li L, et al. Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development. Proc Natl Acad Sci U S A. 2015;112:4447-52 pubmed publisher
    Myocardin is a muscle-restricted transcriptional coactivator that activates a serum response factor (SRF)-dependent gene program required for cardiogenesis and embryonic survival...
  14. Paradis F, Wood K, Swanson K, Miller S, McBride B, Fitzsimmons C. Maternal nutrient restriction in mid-to-late gestation influences fetal mRNA expression in muscle tissues in beef cattle. BMC Genomics. 2017;18:632 pubmed publisher
    ..myogenic (Myogenic Differentiation 1 (MYOD1), Myogenin (MYOG), Myocyte Enhancer Factor 2A (MEF2A), Serum Response Factor (SRF)) and adipogenic (Peroxisome Proliferator Activated Receptor Gamma (PPARG)) genes in fetal ..
  15. He J, Quintana M, Sullivan J, L Parry T, J Grevengoed T, Schisler J, et al. MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet. Cardiovasc Diabetol. 2015;14:97 pubmed publisher
    ..the muscle-specific ubiquitin ligase muscle ring finger-2 (MuRF2) in inhibiting the nuclear transcription factor SRF. Initial studies of MuRF2-/- hearts revealed enhanced PPAR activity, leading to the hypothesis that MuRF2 regulates ..
  16. Chettimada S, Joshi S, Dhagia V, Aiezza A, Lincoln T, Gupte R, et al. Vascular smooth muscle cell contractile protein expression is increased through protein kinase G-dependent and -independent pathways by glucose-6-phosphate dehydrogenase inhibition and deficiency. Am J Physiol Heart Circ Physiol. 2016;311:H904-H912 pubmed publisher
    ..mice revealed uniform increases in VSMC-restricted genes, particularly those regulated by the MYOCD-serum response factor (SRF) switch. Conversely, expression of Krüppel-like factor 4 (KLF4) is decreased by G6PD inhibition...
  17. Tarnawski A, Ahluwalia A. Molecular mechanisms of epithelial regeneration and neovascularization during healing of gastric and esophageal ulcers. Curr Med Chem. 2012;19:16-27 pubmed
    ..b>Serum response factor (SRF) is also essential for re-epithelialization and muscle restoration...
  18. Wang T, Chen K, Hsu P, Lin H, Wang Y, Chen C, et al. microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the synthetic phenotype. J Cell Mol Med. 2017;21:3592-3601 pubmed publisher
    ..KLF4 can reduce VSMC-specific gene expression by preventing myocardin-serum response factor (SRF) complex from associating with these gene promoters...
  19. Xu H, Du S, Fang B, Li C, Jia X, Zheng S, et al. VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure. Proc Natl Acad Sci U S A. 2019;116:8457-8462 pubmed publisher
    ..in α-SM actin (α-SMA), SM22α, and SM differentiation marker genes myosin heavy chain (SMMHC) levels and serum response factor (SRF) transcriptional activity...
  20. Wen Y, Ushio H. Ferulic Acid Promotes Hypertrophic Growth of Fast Skeletal Muscle in Zebrafish Model. Nutrients. 2017;9: pubmed publisher
    ..up-regulation of relative mRNA expression levels of myogenic transcriptional factors (MyoD, myogenin and serum response factor (SRF)) and their target genes encoding sarcomeric unit proteins involved in muscular hypertrophy (skeletal ..
  21. Diguet N, Trammell S, Tannous C, Deloux R, Piquereau J, Mougenot N, et al. Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy. Circulation. 2018;137:2256-2273 pubmed publisher
    ..in the human failing heart and in the heart of a mouse model of dilated cardiomyopathy (DCM) triggered by Serum Response Factor transcription factor depletion in the heart (SRFHKO) or of cardiac hypertrophy triggered by ..
  22. Bian H, Lin J, Li C, Farmer S. Myocardin-related transcription factor A (MRTFA) regulates the fate of bone marrow mesenchymal stem cells and its absence in mice leads to osteopenia. Mol Metab. 2016;5:970-979 pubmed publisher
    ..transcription factors (MRTFs) dissociate from bound G-actin and enter the nucleus to co-activate serum response factor (SRF) target gene expression...
  23. Lauriol J, Keith K, Jaffré F, Couvillon A, Saci A, Goonasekera S, et al. RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis. Sci Signal. 2014;7:ra100 pubmed publisher
    ..activation of genes involved in fibrosis, including myocardin response transcription factor (MRTF) and serum response factor (SRF), suggesting that the fibrotic response to stress in the heart depends on cardiomyocyte-specific RhoA ..
  24. Zhang X, Azhar G, Rogers S, Foster S, Luo S, Wei J. Overexpression of p49/STRAP alters cellular cytoskeletal structure and gross anatomy in mice. BMC Cell Biol. 2014;15:32 pubmed publisher
    The protein p49/STRAP (SRFBP1) is a transcription cofactor of serum response factor (SRF) which regulates cytoskeletal and muscle-specific genes. Two conserved domains were found in the p49/STRAP protein...
  25. Misra V, Wang Y, Timko M. A compendium of transcription factor and Transcriptionally active protein coding gene families in cowpea (Vigna unguiculata L.). BMC Genomics. 2017;18:898 pubmed publisher
    ..whereas members of the MADS (Minichromosome maintenance deficient 1 (MCM1), AGAMOUS, DEFICIENS, and serum response factor (SRF)) and C2C2-YABBY appear to be under-represented...
  26. Lee S, Lee J, Lee S. UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program. Dev Cell. 2012;22:25-37 pubmed publisher
  27. Kikuchi K, Shiota J, Yamada T, Ishikawa M, Ihara D, Fukuchi M, et al. Rho signaling inhibitor, CCG-1423, inhibits axonal elongation and dendritic complexity of rat cortical neurons. Biochem Biophys Res Commun. 2017;492:474-479 pubmed publisher
    CCG-1423, a chemical inhibitor of Rho signaling, blocks serum response factor (SRF)/megakaryoblastic leukemia 1 (MKL1)-mediated gene expression by inhibiting the nuclear accumulation of MKL1...
  28. Mokalled M, Carroll K, Cenik B, Chen B, Liu N, Olson E, et al. Myocardin-related transcription factors are required for cardiac development and function. Dev Biol. 2015;406:109-16 pubmed publisher
    ..A and B (MRTF-A and MRTF-B) are highly homologous proteins that function as powerful coactivators of serum response factor (SRF), a ubiquitously expressed transcription factor essential for cardiac development...
  29. Razak K, Yarrow S, Brewton D. Mechanisms of Sound Localization in Two Functionally Distinct Regions of the Auditory Cortex. J Neurosci. 2015;35:16105-15 pubmed publisher
    ..The data reveal the following major differences between these two regions: (1) compared with NSR neurons, SRF properties of FMSR neurons were more strongly dependent on sound level; (2) as a population, NSR neurons represent ..
  30. Hermann M, Jakobson M, Colo G, Rognoni E, Jakobson M, Kupatt C, et al. Integrins synergise to induce expression of the MRTF-A-SRF target gene ISG15 for promoting cancer cell invasion. J Cell Sci. 2016;129:1391-403 pubmed publisher
    ..integrin contained different G-actin pools, nuclear MRTF-A (also known as MKL1 or MAL) levels and MRTF-A-SRF activities...
  31. Pertl L, Haas A, Hausberger S, Pichler T, Rabensteiner D, Seidel G, et al. CHANGE OF CHOROIDAL VOLUME IN UNTREATED CENTRAL SEROUS CHORIORETINOPATHY. Retina. 2017;37:1792-1796 pubmed publisher
    ..In active CSC undergoing treatment, choroidal thickness decreases if subretinal fluid (SRF) resolves. This study aimed to investigate the change in choroidal thickness and volume in eyes with untreated CSC...
  32. Manak J, Prywes R. Mutation of serum response factor phosphorylation sites and the mechanism by which its DNA-binding activity is increased by casein kinase II. Mol Cell Biol. 1991;11:3652-9 pubmed
    Casein kinase II (CKII) phosphorylates the mammalian transcription factor serum response factor (SRF) on a serine residue(s) located within a region of the protein spanning amino acids 70 to 92, thereby enhancing its DNA-binding activity ..
  33. Fujii M, Chuhjo T, Minamino T, Masaaki N, Miyamoto K, Seiki M. Identification of the Tax interaction region of serum response factor that mediates the aberrant induction of immediate early genes through CArG boxes by HTLV-I Tax. Oncogene. 1995;11:7-14 pubmed
    ..To do this, Tax does not directly bind to the CArG box, but instead binds to the CArG binding factor SRF. In this study, we investigated the domain of SRF required for the activation by Tax and studied the role of this ..
  34. Di Lonardo M, Franzese M, Costa G, Gavasci R, Lombardi F. The application of SRF vs. RDF classification and specifications to the material flows of two mechanical-biological treatment plants of Rome: Comparison and implications. Waste Manag. 2016;47:195-205 pubmed publisher
    This work assessed the quality in terms of solid recovered fuel (SRF) definitions of the dry light flow (until now indicated as refuse derived fuel, RDF), heavy rejects and stabilisation rejects, produced by two mechanical biological ..
  35. Kim T, Yang S, Hwang D, Song J, Kim M, Kyum Kim S, et al. A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness. Nat Commun. 2015;6:10186 pubmed publisher
    ..Specifically, serum response factor (SRF)-mediated binding and recruitment of YAP to mammary stem cell (MaSC) signature-gene promoters induce ..
  36. Ye X, Qian Y, Wang Q, Yuan W, Mo X, Li Y, et al. SMYD1, an SRF-Interacting Partner, Is Involved in Angiogenesis. PLoS ONE. 2016;11:e0146468 pubmed publisher
    ..Furthermore, Co-IP and GST pull-down assays demonstrated that SMYD1 is associated with the Serum Response Factor (SRF)...
  37. Kang S, Park Y, Kim J, Seifert E, Theisen Kunde D, Brinkmann R, et al. Selective Retina Therapy in Patients With Chronic Central Serous Chorioretinopathy: A Pilot Study. Medicine (Baltimore). 2016;95:e2524 pubmed publisher
    We evaluated visual outcomes, changes of maximum macular thickness (MMT) and subretinal fluid (SRF), and safety in patients with chronic central serous chorioretinopathy (CSC) after treatment with selective retina therapy (SRT)...
  38. Eissa M, Abdelhakim M, Macky T, Khafagy M, Mortada H. Functional and structural outcomes of ILM peeling in uncomplicated macula-off RRD using microperimetry & en-face OCT. Graefes Arch Clin Exp Ophthalmol. 2018;256:249-257 pubmed publisher
    ..image analysis (retinal dimples), and SD-OCT changes [epiretinal membrane (ERM), subretinal fluid (SRF), ellipsoid zone disruption, central subfoveal thickness (CSFT), and foveal contour]...
  39. Hatayama M, Aruga J. Role of Zic Family Proteins in Transcriptional Regulation and Chromatin Remodeling. Adv Exp Med Biol. 2018;1046:353-380 pubmed publisher
    ..bind many proteins including transcription factors (Gli1-3, Tcf1 or Tcf4, Smad2 or Smad3, Oct4, Pax3, Cdx, and SRF), chromatin-remodeling factors (NuRD and NURF), and other nuclear enzymes (DNA-PK, PARP1, and RNA helicase A)...
  40. Asanoma K, Kato H, Yamaguchi S, Shin C, Liu Z, Kato K, et al. HOP/NECC1, a novel regulator of mouse trophoblast differentiation. J Biol Chem. 2007;282:24065-74 pubmed
    ..Negative regulation of SRF (serum response factor) by the binding of HOP/NECC1 protein contributed at least in part to the generation of these placental ..
  41. Lin C, Hindes A, Burns C, Koppel A, Kiss A, Yin Y, et al. Serum response factor controls transcriptional network regulating epidermal function and hair follicle morphogenesis. J Invest Dermatol. 2013;133:608-617 pubmed publisher
    b>Serum response factor (SRF) is a transcription factor that regulates the expression of growth-related immediate-early, cytoskeletal, and muscle-specific genes to control growth, differentiation, and cytoskeletal integrity in different ..
  42. Chandrasekharam V. Laparoscopic pyeloplasty in infants: single-surgeon experience. J Pediatr Urol. 2015;11:272.e1-5 pubmed publisher
    ..In unilateral cases, there was significant improvement in mean split renal function (SRF) of the operated kidneys (pre-operative 22.1% (SD 8.6) versus post-operative 35.6% (SD 11.4), p < 0.001)...
  43. Esnault S, Torr E, Bernau K, Johansson M, Kelly E, Sandbo N, et al. Endogenous Semaphorin-7A Impedes Human Lung Fibroblast Differentiation. PLoS ONE. 2017;12:e0170207 pubmed publisher
    ..increased ?-smooth muscle actin production and gene expression of periostin, fibronectin, laminin, and serum response factor (SRF), indicating differentiation into a myofibroblast...
  44. Cheng X, Li S, Mao C, Wang M, Chen J, Wang F, et al. Serum Response Factor Promotes Dopaminergic Neuron Survival via Activation of Beclin 1-Dependent Autophagy. Neuroscience. 2018;371:288-295 pubmed publisher
    b>Serum response factor (SRF), a transcription factor highly expressed in neurons, is involved in neuronal survival and the pathogenesis of some neurodegenerative disorders...
  45. Zhang X, Azhar G, Wei J. SIRT2 gene has a classic SRE element, is a downstream target of serum response factor and is likely activated during serum stimulation. PLoS ONE. 2017;12:e0190011 pubmed publisher
    ..Several studies indicate that SIRT2 is upregulated under serum deprivation conditions. Since the serum response factor gene usually responds rapidly to serum deprivation and/or serum restoration following deprivation, we ..
  46. Liu J, Liu P, Wang J, Xu X, Li D, Zhang J, et al. Fabrication and Sintering Behavior of Er:SrF? Transparent Ceramics using Chemically Derived Powder. Materials (Basel). 2018;11: pubmed publisher
    In this paper, we report the fabrication of high-quality 5 at. % Er3+ ions doped SrF? transparent ceramics, the potential candidate materials for a mid-infrared laser-gain medium by hot-pressing at 700 °C for 40 h using a ..
  47. Liu S, Peng B, Ma J, Liu Y, Ng S. Serum response element associated transcription factors in mouse embryos: serum response factor, YY1, and PEA3 factor. Dev Genet. 1995;16:229-40 pubmed
    ..b>SRF binds WGA-agarose and apparently is O-glycosylated...
  48. Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill M, Engel K, et al. MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo. J Biol Chem. 1999;274:14434-43 pubmed
    ..calcium-regulated kinases such as pp90(rsk) or CaM kinase IV can phosphorylate the transcription factor serum response factor (SRF) at serine 103 (Ser-103)...
  49. Zhang M, Fang H, Zhou J, Herring B. A novel role of Brg1 in the regulation of SRF/MRTFA-dependent smooth muscle-specific gene expression. J Biol Chem. 2007;282:25708-16 pubmed
    b>Serum response factor (SRF) is a key regulator of smooth muscle differentiation, proliferation, and migration...
  50. Nanda V, Miano J. Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells. J Biol Chem. 2012;287:2459-67 pubmed publisher
    ..SMC) differentiation is defined largely by a number of cell-restricted genes governed directly by the serum response factor (SRF)/myocardin (MYOCD) transcriptional switch...
  51. Rubil S, Rössler O, Thiel G. CREB, AP-1, ternary complex factors and MAP kinases connect transient receptor potential melastatin-3 (TRPM3) channel stimulation with increased c-Fos expression. Br J Pharmacol. 2016;173:305-18 pubmed publisher
    ..level, three Ca(2+) -responsive elements, the cAMP-response element and the binding sites for the serum response factor (SRF) and AP-1, are essential for the TRPM3-mediated stimulation of the c-Fos promoter...
  52. Bai X, Mangum K, Dee R, Stouffer G, Lee C, Oni Orisan A, et al. Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding. J Clin Invest. 2017;127:670-680 pubmed publisher
    ..Taken together, our data add insight into the genetic mechanisms that control blood pressure and provide a potential target for individualized antihypertensive therapies. ..
  53. Smith M, Hudson C, Kimura T, White S, Sala Newby G, Newby A, et al. Divergent Regulation of Actin Dynamics and Megakaryoblastic Leukemia-1 and -2 (Mkl1/2) by cAMP in Endothelial and Smooth Muscle Cells. Sci Rep. 2017;7:3681 pubmed publisher
    ..Here we investigated the effects of cAMP-induced cytoskeletal remodelling on the serum response factor (SRF) co-factors Megakaryoblastic Leukemia-1 and -2 (MKL1 and MKL2) and their role in controlling VSMC and ..
  54. Kim H, Kim J, Lee J. Steroid receptor coactivator-1 interacts with serum response factor and coactivates serum response element-mediated transactivations. J Biol Chem. 1998;273:28564-7 pubmed
    Steroid receptor coactivator-1 (SRC-1) specifically bound to serum response factor (SRF), as demonstrated by glutathione S-transferase pull down assays, and the yeast and mammalian two-hybrid tests...
  55. Weinl C, Castaneda Vega S, Riehle H, Stritt C, Calaminus C, Wolburg H, et al. Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke. Proc Natl Acad Sci U S A. 2015;112:9914-9 pubmed publisher
    ..Srf(iECKO) mice, permitting conditional EC-specific depletion of the transcription factor Serum Response Factor (SRF), suffer from loss of BBB integrity and intracerebral hemorrhaging...
  56. Jonchère V, Alqadri N, Herbert J, Dodgson L, Mason D, Messina G, et al. Transcriptional responses to hyperplastic MRL signalling in Drosophila. Open Biol. 2017;7: pubmed publisher
    ..its effect on the myocardin-related transcription factor (Mrtf), an F-actin sensor capable of activating serum response factor (SRF)...
  57. Berry J, Shih G, Moysidis S, Jubran R, Wong K, Lee T, et al. Patterns of subretinal fluid resolution in Group D eyes treated with chemoreduction: Experience from the Children's Hospital Los Angeles/University of Southern California. Ophthalmic Genet. 2016;37:400-403 pubmed
    The purpose of this study was to evaluate patterns of subretinal fluid (SRF) resolution in Group D retinoblastoma eyes. Fifty-three Group D eyes were evaluated for the presence of SRF at diagnosis...
  58. Liu Z, Wang H, Zhang X, Liu J, Zhou Y. Dechlorination of organochloride waste mixture by microwave irradiation before forming solid recovered fuel. Waste Manag. 2017;62:118-124 pubmed publisher
    In order to form a modified solid recovered fuel (SRF) with low chlorine content, high calorific value and well combustion performance, low temperature microwave irradiation was applied to remove the chlorine of the organochloride waste ..
  59. Xu M, Gonzalez Hurtado E, Martinez E. Core promoter-specific gene regulation: TATA box selectivity and Initiator-dependent bi-directionality of serum response factor-activated transcription. Biochim Biophys Acta. 2016;1859:553-63 pubmed publisher
    ..a TATA box-selective activating sequence upstream of the human β-actin (ACTB) gene that mediates serum response factor (SRF)-induced transcription from TATA-dependent but not INR-dependent promoters and requires the TATA-..
  60. Xu Q, Wang Q, Zhang W, Yang P, Du Y, Wang D. Highly effective enhancement of waste activated sludge dewaterability by altering proteins properties using methanol solution coupled with inorganic coagulants. Water Res. 2018;138:181-191 pubmed publisher
    ..traditional inorganic coagulants in improving sludge dewaterability in term of specific resistance to filtration (SRF) and cake solid content (CSC)...
  61. Zhang H, Jiang L, Guo Z, Zhong J, Wu J, He J, et al. PPARβ/δ, a Novel Regulator for Vascular Smooth Muscle Cells Phenotypic Modulation and Vascular Remodeling after Subarachnoid Hemorrhage in Rats. Sci Rep. 2017;7:45234 pubmed publisher
    ..following study demonstrated that PPARβ/δ-induced PI3K/AKT activation can also contribute to Serum Response Factor (SRF) nucleus localization and Myocardin expression, which was highly associated with VSMC phenotypic ..
  62. Rautenbach M, Vlok N, Eyéghé Bickong H, van der Merwe M, Stander M. An Electrospray Ionization Mass Spectrometry Study on the "In Vacuo" Hetero-Oligomers Formed by the Antimicrobial Peptides, Surfactin and Gramicidin S. J Am Soc Mass Spectrom. 2017;28:1623-1637 pubmed publisher
    It was previously observed that the lipopeptide surfactants in surfactin (Srf) have an antagonistic action towards the highly potent antimicrobial cyclodecapeptide, gramicidin S (GS)...
  63. Willer M, Carroll C. Substrate stiffness-dependent regulation of the SRF-Mkl1 co-activator complex requires the inner nuclear membrane protein Emerin. J Cell Sci. 2017;130:2111-2118 pubmed publisher
    The complex comprising serum response factor (SRF) and megakaryoblastic leukemia 1 protein (Mkl1) promotes myofibroblast differentiation during wound healing...
  64. Runowski M, Marciniak J, Grzyb T, Przybylska D, Shyichuk A, Barszcz B, et al. Lifetime nanomanometry - high-pressure luminescence of up-converting lanthanide nanocrystals - SrF2:Yb3+,Er3. Nanoscale. 2017;9:16030-16037 pubmed publisher
    Anti-Stokes luminescence of up-converting nanocrystals SrF2:Yb3+,Er3+ can be used as a high pressure optical sensor alternative to the ruby fluorescence-scale...
  65. Joliot V, Demma M, Prywes R. Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor. Nature. 1995;373:632-5 pubmed
    ..show that the general transcription factor TFIIF is also a target for a transcriptional activator, namely serum response factor (SRF), which binds to the c-fos promoter...
  66. Janknecht R, Ernst W, Houthaeve T, Nordheim A. C-terminal phosphorylation of the serum-response factor. Eur J Biochem. 1993;216:469-75 pubmed
    The serum-response factor (SRF) is essential for the induction and repression of the protooncogene c-fos...
  67. Watson D, Robinson L, Hodge D, Kola I, Papas T, Seth A. FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements. Oncogene. 1997;14:213-21 pubmed
    ..ELK1 and SAP1a have been shown to form ternary complexes with SRF on the SRE located in the c-fos promoter...
  68. Cooper S, Trinklein N, Nguyen L, Myers R. Serum response factor binding sites differ in three human cell types. Genome Res. 2007;17:136-44 pubmed
    The serum response factor (SRF) is essential for embryonic development and maintenance of muscle cells and neurons. The mechanism by which this factor controls these divergent pathways is unclear...
  69. Long X, Tharp D, Georger M, Slivano O, Lee M, Wamhoff B, et al. The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin. J Biol Chem. 2009;284:33671-82 pubmed publisher
    ..Gel shift and chromatin immunoprecipitation assays confirmed serum response factor (SRF) binding to both CArG elements...
  70. Jin W, Goldfine A, Boes T, Henry R, Ciaraldi T, Kim E, et al. Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance. J Clin Invest. 2011;121:918-29 pubmed publisher
    ..Actin cytoskeleton genes regulated by serum response factor (SRF) and its coactivator megakaryoblastic leukemia 1 (MKL1) had increased expression in T2D and FH(+) ..
  71. Lewis A, Riddoch Contreras J, Natanek S, Donaldson A, Man W, Moxham J, et al. Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD. Thorax. 2012;67:26-34 pubmed publisher
    ..Muscle-specific microRNAs and serum response factor (SRF) are important regulators of muscle phenotype that contribute to a feedback system to regulate muscle ..
  72. Makdoumi K, Nilsson T, Crafoord S. Levels of beta-trace protein in optic disc pit with macular detachment. Acta Ophthalmol. 2017;95:815-819 pubmed publisher
    To report beta-trace protein (?TP) levels in the subretinal fluid (SRF) of four patients with a macular detachment associated with optic disc pit (ODP)...
  73. Takata A, Otsuka M, Kishikawa T, Yamagami M, Ishibashi R, Sekiba K, et al. RASAL1 is a potent regulator of hepatic stellate cell activity and liver fibrosis. Oncotarget. 2017;8:64840-64852 pubmed publisher
    ..regulating the Ras-MAPK pathway, and that RASAL1 suppresses HSC fibrogenic activity by regulating the PKA-LKB1-AMPK-SRF pathway by interacting with angiotensin II receptor, type 1...
  74. Grueneberg D, Henry R, Brauer A, Novina C, Cheriyath V, Roy A, et al. A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I. Genes Dev. 1997;11:2482-93 pubmed
    The human homeodomain protein Phox1 interacts functionally with serum response factor (SRF) to impart serum responsive transcriptional activity to SRF-binding sites in a HeLa cell cotransfection assay...
  75. Mo Y, Ho W, Johnston K, Marmorstein R. Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex. J Mol Biol. 2001;314:495-506 pubmed
    ..that mediates ternary complex formation with the Ets proteins SAP-1 or Elk-1 and the MADS-box protein, serum response factor (SRF)...
  76. Davis F, Gupta M, Camoretti Mercado B, Schwartz R, Gupta M. Calcium/calmodulin-dependent protein kinase activates serum response factor transcription activity by its dissociation from histone deacetylase, HDAC4. Implications in cardiac muscle gene regulation during hypertrophy. J Biol Chem. 2003;278:20047-58 pubmed
    b>Serum response factor (SRF) plays a pivotal role in cardiac myocyte development, muscle gene transcription, and hypertrophy...
  77. Raimundo N, Vanharanta S, Aaltonen L, Hovatta I, Suomalainen A. Downregulation of SRF-FOS-JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas. Oncogene. 2009;28:1261-73 pubmed publisher
    ..transcriptional fingerprint with FH-deficient and sporadic leiomyomas, highlighting the downregulation of serum response factor (SRF)-regulated transcripts, particularly the FOS-JUNB pathway...
  78. Walker T, Nolte A, Steger V, Makowiecki C, Mustafi M, Friedel G, et al. Small interfering RNA-mediated suppression of serum response factor, E2-promotor binding factor and survivin in non-small cell lung cancer cell lines by non-viral transfection. Eur J Cardiothorac Surg. 2013;43:628-33; discussion 633-4 pubmed publisher
    b>Serum response factor (SRF), E2F1 and survivin are well-known factors involved in a multitude of cancer-related regulation processes...
  79. Huang W, Morales J, Gazivoda V, Lai J, Qi Q, August A. The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with G?13 and activation of serum response factor. Int J Biochem Cell Biol. 2013;45:1074-82 pubmed publisher
    ..Itk enhances G?13 mediated activation of serum response factor (SRF) transcriptional activity dependent on its ability to interact with G?13, but its kinase activity is ..
  80. Liu Z, Zhang J, Gao Y, Pei L, Zhou J, Gu L, et al. Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis. Clin Cancer Res. 2014;20:4598-612 pubmed publisher
    ..These genes included BMP3, BNIP3, CDKN2A, ECEL1, ELK1, GFRA1, HOXD10, KCNH1, PSMD10, PTPRT, SIGIRR, SRF, TBX5, TFPI2, and ZNF382...
  81. Rini Ann Jerin A, Kaliannan P, Subramaniam U. Improved fault ride through capability of DFIG based wind turbines using synchronous reference frame control based dynamic voltage restorer. ISA Trans. 2017;70:465-474 pubmed publisher
    ..The effectiveness of the DVR using Synchronous reference frame (SRF) control is investigated for FRT capability in DFIG-WT during both balanced and unbalanced fault conditions...
  82. Haga F, Maruko R, Sato C, Kataoka K, Ito Y, Terasaki H. Long-term prognostic factors of chronic central serous chorioretinopathy after half-dose photodynamic therapy: A 3-year follow-up study. PLoS ONE. 2017;12:e0181479 pubmed publisher
    To evaluate the long-term efficacy and factors involved in the recurrence and persistence of subretinal fluid (SRF) after half-dose photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSC)...
  83. Oellers P, Eliott D. Overloaded Dysfunctional RPE Leads to Delayed Absorption of Subretinal Fluid After Retinal Detachment Repair. Ophthalmic Surg Lasers Imaging Retina. 2017;48:852-855 pubmed publisher
    Persistent subretinal fluid (SRF) can impair visual recovery after vitrectomy or scleral buckling surgery for rhegmatogenous retinal detachment...
  84. Park J, Lee J, Yeom Z, Heo D, Lim Y. Neuroprotective effect of Ruminococcus albus on oxidatively stressed SH-SY5Y cells and animals. Sci Rep. 2017;7:14520 pubmed publisher
    ..CRA-CM up-regulated the protein expression levels of SRF, C-fos and CDK2. In addition, CRA-CM protected SH-SY5Y cells from H2O2-induced cell death...
  85. Kim D, Cheriyath V, Roy A, Cochran B. TFII-I enhances activation of the c-fos promoter through interactions with upstream elements. Mol Cell Biol. 1998;18:3310-20 pubmed
    ..Mutations that distinguish between serum response factor (SRF), STAT, and TFII-I binding to the c-fos SIE and SRE suggest that the binding of TFII-I to these ..
  86. Spencer J, Baron M, Olson E. Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1. J Biol Chem. 1999;274:15686-93 pubmed
    b>Serum response factor (SRF) is a MADS box transcription factor that controls a wide range of genes involved in cell proliferation and differentiation...
  87. Li H, Haque Z, Lu Q, Li L, Karas R, Mendelsohn M. Steroid receptor coactivator 3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation. Proc Natl Acad Sci U S A. 2007;104:4065-70 pubmed
  88. Kim J, Kee H, Kim J, Joung H, Nam K, Eom G, et al. Enhancer of polycomb1 acts on serum response factor to regulate skeletal muscle differentiation. J Biol Chem. 2009;284:16308-16 pubmed publisher
    ..Here we report that Epc1 recruits both serum response factor (SRF) and p300 to induce skeletal muscle differentiation. Epc1 interacted physically with SRF...
  89. Rodríguez Tornos F, San Aniceto I, Cubelos B, Nieto M. Enrichment of conserved synaptic activity-responsive element in neuronal genes predicts a coordinated response of MEF2, CREB and SRF. PLoS ONE. 2013;8:e53848 pubmed publisher
    A unique synaptic activity-responsive element (SARE) sequence, composed of the consensus binding sites for SRF, MEF2 and CREB, is necessary for control of transcriptional upregulation of the Arc gene in response to synaptic activity...
  90. O Hurley G, Prencipe M, Lundon D, O Neill A, Boyce S, O Grady A, et al. The analysis of serum response factor expression in bone and soft tissue prostate cancer metastases. Prostate. 2014;74:306-13 pubmed publisher
    ..We recently identified serum response factor (SRF) as a key transcription factor in an in vitro model of castration resistance where we showed that SRF ..
  91. Lingerfelt M, Zhao P, Sharir H, Hurst D, Reggio P, Abood M. Identification of Crucial Amino Acid Residues Involved in Agonist Signaling at the GPR55 Receptor. Biochemistry. 2017;56:473-486 pubmed publisher
    ..Serum response element (SRE) and serum response factor (SRF) luciferase assays were used as readouts for studying LPI and ML184 signaling at the GPR55 mutants...
  92. Millward Hopkins J, Busch J, Purnell P, Zwirner O, Velis C, Brown A, et al. Fully integrated modelling for sustainability assessment of resource recovery from waste. Sci Total Environ. 2018;612:613-624 pubmed publisher
    ..potential impacts that may follow the increased use of low-carbon fuels (biomass and solid recovered fuels; SRF) in the former. We explore synergies and trade-offs in value across domains and regions, e.g...