SREBP-1

Summary

Gene Symbol: SREBP-1
Description: sterol regulatory element binding transcription factor 1
Alias: SREBP-1c, SREBP1, SREBP1a, bHLHd1, sterol regulatory element-binding protein 1, class D basic helix-loop-helix protein 1
Species: human

Top Publications

  1. pmc SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element
    X Hua
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    Proc Natl Acad Sci U S A 90:11603-7. 1993
  2. doi Human caspase 7 is positively controlled by SREBP-1 and SREBP-2
    Laure Gibot
    INSERM, UMR 613, Universite de Brest, 22 avenue Camille Desmoulins, Brest Cedex 3, France
    Biochem J 420:473-83. 2009
  3. doi Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway
    Candice Jackel-Cram
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Gen Virol 91:1388-95. 2010
  4. ncbi Genetic variant of the SREBF-1 gene is significantly related to cholesterol synthesis in man
    Reijo Laaksonen
    Department of Internal Medicine, University Hospital of Tampere, Tampere, Finland
    Atherosclerosis 185:206-9. 2006
  5. pmc Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step
    Joon No Lee
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 283:33772-83. 2008
  6. pmc 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway
    Yongjie Ma
    Veterans Affairs McGuire Medical Center Virginia Commonwealth University, Richmond, VA 23249, USA
    Am J Physiol Endocrinol Metab 295:E1369-79. 2008
  7. pmc Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling
    Marshall B Elam
    Department of Medicine and Research Service, Department of Veterans Affairs Medical Center, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
    Metabolism 59:587-98. 2010
  8. ncbi Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution
    A Parraga
    Laboratories of Molecular Biophysics, Rockefeller University, New York, NY 10021, USA
    Structure 6:661-72. 1998
  9. ncbi Insulin action on expression of novel adipose genes in healthy and type 2 diabetic subjects
    Heikki A Koistinen
    Department of Surgical Sciences, Karolinska Institute, Stockholm, Sweden
    Obes Res 12:25-31. 2004
  10. ncbi Identification of a functional DNA binding site for the SREBP-1c transcription factor in the first intron of the human caspase-2 gene
    E Logette
    INSERM U517, IFR100, Faculte de Medecine, 7 bd Jeanne of Arc, 21000 Dijon, France
    Biochim Biophys Acta 1738:1-5. 2005

Research Grants

  1. Role of Stearoyl-CoA Desaturase in Metabolism
    James M Ntambi; Fiscal Year: 2010
  2. Jeffrey E Pessin; Fiscal Year: 2016
  3. Marshall B Elam; Fiscal Year: 2014
  4. Min You; Fiscal Year: 2016
  5. Regulation of SREBP-1c Processing by Insulin and Cyclic-AMP
    Marshall B Elam; Fiscal Year: 2010
  6. Sudha B Biddinger; Fiscal Year: 2015
  7. Vsevolod Y Polotsky; Fiscal Year: 2014
  8. Alcohol-Induced Fatty Liver and Injury in Humanized CYP2E1 Knockin Mice.
    Arthur I Cederbaum; Fiscal Year: 2011
  9. JOSHUA JAMES ZIAREK; Fiscal Year: 2014
  10. Terry G Unterman; Fiscal Year: 2016

Detail Information

Publications228 found, 100 shown here

  1. pmc SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element
    X Hua
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    Proc Natl Acad Sci U S A 90:11603-7. 1993
    ..At high levels transcription reached a maximum, and the effects were no longer additive. The reason for the existence of two SREBPs and the mechanism by which they are regulated by sterols remain to be determined...
  2. doi Human caspase 7 is positively controlled by SREBP-1 and SREBP-2
    Laure Gibot
    INSERM, UMR 613, Universite de Brest, 22 avenue Camille Desmoulins, Brest Cedex 3, France
    Biochem J 420:473-83. 2009
    ..Taken together, our results show that caspase 7, as an SREBP-1/2 target, can be induced under mevalonate-restricting conditions, which might help overcome its shortage...
  3. doi Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway
    Candice Jackel-Cram
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Gen Virol 91:1388-95. 2010
    ..These results indicate a role for PI3K and Akt-2 in increasing SREBP-1 activity by HCV-3a core protein and provide a mechanism of steatosis caused by HCV...
  4. ncbi Genetic variant of the SREBF-1 gene is significantly related to cholesterol synthesis in man
    Reijo Laaksonen
    Department of Internal Medicine, University Hospital of Tampere, Tampere, Finland
    Atherosclerosis 185:206-9. 2006
    ..Similarly muscle cholesterol (p=0.045) and lathosterol (p=0.054) concentrations were elevated in the CC homozygotes supporting the view that endogenous cholesterol synthesis rate is SREBF-1 genotype-dependent...
  5. pmc Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step
    Joon No Lee
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 283:33772-83. 2008
    ..The current study provides a molecular mechanism for regulation of proteasome-mediated ER protein degradation at a postubiquitination step...
  6. pmc 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway
    Yongjie Ma
    Veterans Affairs McGuire Medical Center Virginia Commonwealth University, Richmond, VA 23249, USA
    Am J Physiol Endocrinol Metab 295:E1369-79. 2008
    ..We conclude that 25HC3S acts in macrophages as a cholesterol satiety signal, downregulating cholesterol and fatty acid synthetic pathways via inhibition of LXR/SREBP signaling. A possible role of oxysterol sulfation is proposed...
  7. pmc Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling
    Marshall B Elam
    Department of Medicine and Research Service, Department of Veterans Affairs Medical Center, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
    Metabolism 59:587-98. 2010
    ....
  8. ncbi Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution
    A Parraga
    Laboratories of Molecular Biophysics, Rockefeller University, New York, NY 10021, USA
    Structure 6:661-72. 1998
    ..This difference allows recognition of an asymmetric sterol regulatory element (StRE, 5'-ATCACCCAC-3')...
  9. ncbi Insulin action on expression of novel adipose genes in healthy and type 2 diabetic subjects
    Heikki A Koistinen
    Department of Surgical Sciences, Karolinska Institute, Stockholm, Sweden
    Obes Res 12:25-31. 2004
    ..We have studied the expression and acute insulin regulation of novel genes expressed in adipose tissue that are implicated in the control of whole body insulin sensitivity...
  10. ncbi Identification of a functional DNA binding site for the SREBP-1c transcription factor in the first intron of the human caspase-2 gene
    E Logette
    INSERM U517, IFR100, Faculte de Medecine, 7 bd Jeanne of Arc, 21000 Dijon, France
    Biochim Biophys Acta 1738:1-5. 2005
    ..This observation, together with our recent findings, strengthens the notion that the CASP-2 gene belongs to the SREBP-responsive gene battery in human cells...
  11. doi Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2
    Jae Ku Oem
    Vaccine and Infectious Disease Organization VIDO, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E3, Canada
    J Gen Virol 89:1225-30. 2008
    ..Taken together, our results suggest that HCV NS2 can upregulate the transcription of SREBP-1c and FAS, and thus is probably a contributing factor for HCV-associated steatosis...
  12. ncbi Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1)
    R Sato
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 269:17267-73. 1994
    ..This study provides a picture of the domain structure of SREBP-1 and further elucidates the mechanism by which it adjusts gene transcription to maintain cholesterol homeostasis in animal cells...
  13. ncbi SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
    X Wang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    Cell 77:53-62. 1994
    ..Sterol-regulated proteolysis of a membrane-bound transcription factor provides a novel mechanism by which transcription can be regulated by membrane lipids...
  14. pmc Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocyte
    M Moldes
    Universite Pierre et Marie Curie, UPRES A 7079 CNRS, Paris, France
    Biochem J 344:873-80. 1999
    ..Taken together, our data show that Id products are functionally involved in modulating ADD1/SREBP-1c transcriptional activity, and thus lipogenesis in adipocytes...
  15. ncbi Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi
    R A DeBose-Boyd
    Department of Molecular Genetics, University of Texas, Southwestern Medical Center, Dallas 75390 9046, USA
    Cell 99:703-12. 1999
    ..Transport-dependent proteolysis may be a common mechanism to regulate the processing of membrane proteins...
  16. pmc Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport
    F Jeffrey Field
    Department of Veterans Affairs, Iowa City, IA 52242, USA
    Biochem J 368:855-64. 2002
    ..Since all fatty acids decreased fatty acid synthesis, mechanisms other than changes in SREBP-1c expression must be entertained. Increased endogenous fatty acid synthesis does not promote triacylglycerol-rich lipoprotein secretion...
  17. ncbi Sphingolipid storage induces accumulation of intracellular cholesterol by stimulating SREBP-1 cleavage
    Vishwajeet Puri
    Department of Biochemistry and Molecular Biology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 278:20961-70. 2003
    ....
  18. ncbi Functional characterization of the human resistin promoter with adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element binding protein 1c and CCAAT enhancer binding protein-alpha
    Jong Bae Seo
    School of Biological Sciences, Seoul National University, NS 70, San 56 1, Seoul 151 742, Korea
    Mol Endocrinol 17:1522-33. 2003
    ..Together, these data suggest that ADD1/SREBP1c and C/EBP alpha may play discrete roles in the regulation of the resistin gene expression...
  19. ncbi SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes
    Takashi Yamamoto
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    J Biol Chem 279:12027-35. 2004
    ..Our data indicate that SREBP-1 has a novel role as negative regulator of gluconeogenic genes through a cross-talk with HNF-4alpha interference with PGC-1 recruitment...
  20. ncbi A novel SREBP-1 splice variant: tissue abundance and transactivation potency
    Thomas Klaus Felder
    Department of Laboratory Medicine, Salzburger Landeskliniken and Paracelsus Private Medical University, Muellner Hauptstrasse 48, A 5020 Salzburg, Austria
    Biochim Biophys Acta 1731:41-7. 2005
    ..SREBP-1ac did not transactivate the human LDLR and UCP2 promoters but robustly attenuated the transactivation capacity of SREBP-1a, -1c and -2 in cotransfection experiments...
  21. ncbi KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells
    Yongsheng Chang
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Lipid Res 46:2624-35. 2005
    ..In summary, we conclude that KGF requires both PI3K and JNK signaling pathways to induce SREBP-1, which in turn induces SCD-1 and FAS expression in H292 cells...
  22. ncbi Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, One Joslin Pl, Boston, MA 02215, USA
    Diabetes 55:2032-41. 2006
    ..Thus, the effect of leptin on SCD1 in liver is independent of insulin and SREBP-1c, and leptin, rather than insulin, is the major regulator of hepatic MUFA synthesis in obesity-linked diabetes...
  23. doi Alternative splicing produces a constitutively active form of human SREBP-1
    Nagakatsu Harada
    Department of Nutrition and Metabolism, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima City 770 8503, Japan
    Biochem Biophys Res Commun 368:820-6. 2008
    ..Expression levels ranged from 5% to 16% of total SREBP-1 expression. The ratio of SREBP-1Delta expression to total SREBP-1 expression in HepG2 cells was not affected by either insulin or high glucose treatment...
  24. doi Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes
    Adrian Roth
    Division of Pharmacology, Neurobiology, Biozentrum of the University of Basel, Klingelbergstrasse 50 70, Basel, Switzerland
    Pharmacogenet Genomics 18:325-37. 2008
    b>Sterol regulatory element binding protein 1 (SREBP-1) is a lipogenic transcription factor of the basic helix-loop-helix family...
  25. pmc Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN)
    Won Il Choi
    Department of Biochemistry and Molecular Biology, Brain Korea 21 Project for Medical Science, Institute of Genetic Science, Yonsei University School of Medicine, 134, Shinchon dong, Seodaemoon ku, Seoul 120 752, Korea
    J Biol Chem 283:29341-54. 2008
    ....
  26. doi KLF5 enhances SREBP-1 action in androgen-dependent induction of fatty acid synthase in prostate cancer cells
    Min Young Lee
    Institute of Genetic Science, Center for Chronic Disease Research, Yonsei University, College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Republic of Korea
    Biochem J 417:313-22. 2009
    ..Taken together, these results suggest that the FASN gene is activated by the synergistic action of KLF5 and SREBP-1, which was induced by androgen in androgen-dependent prostate cancer cells...
  27. doi In vivo and in vitro effects of SREBP-1 on diabetic renal tubular lipid accumulation and RNAi-mediated gene silencing study
    Hao Jun
    Department of Pathology, Hebei Medical University, Shijiazhuang City, Hebei Province, China
    Histochem Cell Biol 131:327-45. 2009
    ..The application of vector-mediated RNAi could markedly inhibit the expression of SREBP-1 in HKC cells, which is a promising tool for future research into the mechanisms of renal lipid accumulation in vivo...
  28. ncbi Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13
    X Hua
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Genomics 25:667-73. 1995
    Sterol regulatory element binding protein-1 (SREBP1) and SREBP2 are structurally related proteins that control cholesterol homeostasis by stimulating transcription of sterol-regulated genes, including those encoding the low-density ..
  29. ncbi SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene
    C Yokoyama
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    Cell 75:187-97. 1993
    ..We suggest that SREBP-1 is regulated by an unknown factor that is overwhelmed when SREBP-1 is overexpressed. Understanding the regulation of SREBP-1 may be crucial for understanding the control of plasma cholesterol in humans...
  30. ncbi Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane
    X Hua
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 271:10379-84. 1996
    ..These results indicate that sterol-regulated proteolysis of SREBPs is a complex process, requiring sequences on both sides of the ER membrane...
  31. pmc Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
    I Shimomura
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Clin Invest 99:838-45. 1997
    ..2-fold), and the 1c transcript remained virtually undetectable. We conclude that the SREBP-1a and 1c transcripts are controlled independently by regulatory regions that respond differentially to organ-specific and metabolic factors...
  32. ncbi Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein
    J Sakai
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 272:20213-21. 1997
    ....
  33. ncbi Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade
    J Kotzka
    Klinik II und Poliklinik für Innere Medizin at the Center of Molecular Medicine Cologne, D 50924 Cologne, Germany
    J Lipid Res 41:99-108. 2000
    ..We conclude that SREBP-1a and SREBP-2 mediate different regulatory effects converging at sre-1 and that they appear to be linked to the MAP kinase cascade, possibly being direct substrates of ERK1 and ERK2...
  34. ncbi MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro
    G Roth
    Klinik II und Poliklinik für Innere Medizin am Zentrum für Molekulare Medizin der Universität zu Köln and Proteinstrukturlabor der Ruhr Universität Bochum, 50924 Cologne, Germany
    J Biol Chem 275:33302-7. 2000
    ..Our data indicate that the MAP kinase-mediated effects on SREBP-1a-regulated target genes are linked to this phosphorylation site...
  35. ncbi Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
    I Shimomura
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Mol Cell 6:77-86. 2000
    ..The combination of insulin resistance (inappropriate gluconeogenesis) and insulin sensitivity (elevated lipogenesis) establishes a vicious cycle that aggravates hyperinsulinemia and insulin resistance in lipodystrophic and ob/ob mice...
  36. ncbi A new DNA polymorphism in the 5' untranslated region of the human SREBP-1a is related to development of atherosclerosis in high cardiovascular risk population
    B Vedie
    Laboratoire de biochimie appliquée, Faculte des Sciences Pharmaceutiques et Biologiques, Chatenay Malabry, France
    Atherosclerosis 154:589-97. 2001
    ..311, P=0.03). Thus, we have identified a new polymorphism in the 5' untranslated region of the SREBP-1a gene, and demonstrated its association with an atherogenic lipid profile and echographic plaques...
  37. ncbi Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes
    P H Ducluzeau
    Institut National de la Santé et de la Recherche Médicale INSERM U 449, Faculty of Medicine R Laennec, Lyon, France
    Diabetes 50:1134-42. 2001
    ..This study thus provides evidence for a specific defect in the regulation of a group of important genes in response to insulin in peripheral tissues of type 2 diabetic patients...
  38. ncbi Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha
    Ciaran Sewter
    Department of Clinical Biochemistry and Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 51:1035-41. 2002
    ..Exposure of isolated human adipocytes to insulin enhanced SREBP1 gene expression and promoted its proteolytic cleavage to the active form...
  39. ncbi Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes
    Michiyo Amemiya-Kudo
    Department of Metabolic Diseases, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan
    J Lipid Res 43:1220-35. 2002
    ....
  40. ncbi Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
    Tong Yang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Cell 110:489-500. 2002
    ..Mutant SCAP(Y298C) fails to bind INSIG-1 and is resistant to sterol-mediated inhibition of ER exit. By facilitating sterol-dependent ER retention of SCAP, INSIG-1 plays a central role in cholesterol homeostasis...
  41. pmc Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
    Daisuke Yabe
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 99:12753-8. 2002
    ..The combined actions of insig-1 and -2 permit feedback regulation of cholesterol synthesis over a wide range of sterol concentrations...
  42. pmc Effects of SREBF-1a and SCAP polymorphisms on plasma levels of lipids, severity, progression and regression of coronary atherosclerosis and response to therapy with fluvastatin
    Lorraine Salek
    Section of Cardiology, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Mol Med (Berl) 80:737-44. 2002
    ..There were no significant interactions between SCAP genotypes and response to therapy. Thus we detected a strong graded interaction between SREBF-1a -36del/G genotypes and response of plasma apoA-I to treatment with fluvastatin...
  43. ncbi Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c
    Y u An Yang
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA
    Exp Cell Res 282:132-7. 2003
    ..We conclude that regulation of FAS expression in breast cancer is achieved through modulation of SREBP-1c, similar to the regulation in liver and adipose tissue, although the upstream regulation of liopgenesis differs in these tissues...
  44. ncbi SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver
    Kaushik Chakravarty
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 279:15385-95. 2004
    ..We propose that insulin represses transcription of the gene for PEPCK-C by inducing SREBP-1c production in the liver, which interferes with the stimulatory effect of Sp1 at -590 of the PEPCK-C gene promoter...
  45. ncbi Genetic variants in human sterol regulatory element binding protein-1c in syndromes of severe insulin resistance and type 2 diabetes
    Matthias Laudes
    Department of Medicine and Clinical Biochemistry, University of Cambridge Addenbrooke s Hospital, Cambridge, U K
    Diabetes 53:842-6. 2004
    ....
  46. pmc Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis
    Luke J Engelking
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Clin Invest 113:1168-75. 2004
    ..These results provide in vivo support for the hypothesis that nSREBPs are essential for high levels of lipid synthesis in the liver and indicate that Insig's modulate nSREBP levels by binding and retaining SCAP in the ER...
  47. ncbi Sterol regulatory element-binding protein (SREBP)-1: gene regulatory target for insulin resistance?
    Jorg Kotzka
    Klinische Biochemie und Pathobiochemie, Deutsches Diabetes Forschungsinstitut, Leibniz Institut an der Heinrich Heine Universität Düsseldorf, Germany
    Expert Opin Ther Targets 8:141-9. 2004
    ..The authors have recently shown that SREBPs are substrates of mitogen-activated protein kinases, and propose that SREBP-1 might play a role in the development of cellular features belonging to lipotoxicity and, possibly, syndrome X...
  48. ncbi SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts
    Delphine Eberle
    INSERM Unit 465, University Pierre et Marie Curie, Paris, France
    Diabetes 53:2153-7. 2004
    ..03) and increased prevalence of nephropathy (P = 0.028) in a diabetic cohort. Our results indicate a role of the SREBF-1 gene in genetic predisposition of metabolic diseases such as obesity, type 2 diabetes, and dyslipidemia...
  49. ncbi Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products
    Michael Yeh
    Department of Medicine, Geffen School of Medicine at University of California Los Angeles, USA
    Circ Res 95:780-8. 2004
    ..The current studies suggest a novel role for endothelial cholesterol depletion and subsequent SREBP activation in inflammatory processes in which phospholipid oxidation products accumulate...
  50. ncbi Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells
    Akimitsu Takahashi
    Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Diabetes 54:492-9. 2005
    ..Taken together with enhanced insulin secretion from SREBP-1-null islets, these data suggest that SREBP-1c and endogenous lipogenesis could be involved in beta-cell dysfunction and diabetes...
  51. ncbi Effect of sterol regulatory element binding protein-1a on the mitochondrial protein pattern in human liver cells detected by 2D-DIGE
    Stefan Lehr
    Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Heinrich Heine University Dusseldorf, and Leibniz Center for Diabetes Research, Dusseldorf, Germany
    Biochemistry 44:5117-28. 2005
    ..Therefore, the detected protein differences might be an explanation for the observed intracellular lipid accumulation and might link SREBP-1a to features like steatosis hepatis...
  52. ncbi Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)
    Anders Sundqvist
    Ludwig Institute for Cancer Research, Box 595, Husargatan 3, S 751 24 Uppsala, Sweden
    Cell Metab 1:379-91. 2005
    ..Here, we identify a phosphodegron in SREBP1a that serves as a recognition motif for the SCF(Fbw7) ubiquitin ligase...
  53. ncbi The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population
    T K Felder
    Department of Laboratory Medicine, Paracelsus Private Medical University, Salzburg, Austria
    Int J Obes (Lond) 31:1099-103. 2007
    ..The sterol regulatory element-binding protein-1c (SREBP-1c) is a transcription factor involved in the regulation of lipid and glucose metabolism and has been implicated in the pathophysiology of type 2 diabetes mellitus (T2DM)...
  54. ncbi SREBP-1c transcription factor and lipid homeostasis: clinical perspective
    P Ferre
    INSERM, UMR S 671, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    Horm Res 68:72-82. 2007
    ....
  55. ncbi SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma
    Anders Kallin
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Experimental Medicine Unit, Brussels, Belgium
    J Lipid Res 48:1628-36. 2007
    ..In conclusion, our data suggest that SREBP-1 regulates the expression of stress response and signaling genes, which could contribute to the metabolic response to insulin and growth factors in various tissues...
  56. doi Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:1136-42. 2008
    ..Due to the previous inconclusive quantitative trait associations, we also did studies of intermediate quantitative phenotypes...
  57. doi Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?
    S Le Hellard
    Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
    Mol Psychiatry 14:308-17. 2009
    ..Our finding is supported by the recent involvement of the INSIG2 gene in obesity in the general population and implicates SREBP-controlled lipogenesis in drug-induced metabolic adverse effects...
  58. ncbi SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease
    Motoyuki Kohjima
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Mol Med 21:507-11. 2008
    ..These data indicate that, in NAFLD, insulin signaling via IRS-1 causes the up-regulation of SREBP1-c, leading to the increased synthesis of fatty acids by the hepatocytes; negative feedback regulation via AMPK ..
  59. pmc Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis
    Mitsumi Arito
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Biol Chem 283:15224-31. 2008
    ..In summary, growth factors inhibit sumoylation of SREBPs through their phosphorylation, thus avoiding the recruitment of an HDAC3 corepressor complex and stimulating the lipid uptake and synthesis required for cell growth...
  60. doi Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle
    Sophie Rome
    INSERM U870, INRA UMR1235, Régulations Métaboliques, Nutrition, et Diabètes, Universite Lyon 1, Faculté de médecine Lyon Sud, Oullins, INSA Lyon, RMND, Villeurbanne, Lyon, France
    Physiol Genomics 34:327-37. 2008
    ....
  61. doi Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population
    Ju Xiang Liu
    Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Science, 222 South Tianshui Road, Lanzhou University, Lanzhou City, Gansu Province 730000, China
    Diabetes Res Clin Pract 82:42-7. 2008
    ..The present study aimed to confirm the previously reported association in a Chinese population and to examine the two SREBP-1c SNPs for their associations with insulin resistance and blood lipid...
  62. doi Investigation of the role of SREBP-1c in the pathogenesis of HCV-related steatosis
    Stuart McPherson
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Brisbane 4102, Australia
    J Hepatol 49:1046-54. 2008
    ..Our aim was to investigate the role of SREBP-1c in the pathogenesis of HCV-related steatosis...
  63. doi Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma
    Taro Yamashita
    Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Hepatol 50:100-10. 2009
    ..Metabolic dysregulation is one of the risk factors for the development of hepatocellular carcinoma (HCC). We investigated the activated metabolic pathway in HCC to identify its role in HCC growth and mortality...
  64. doi Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk
    Daniele Campa
    Department of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Breast Cancer Res Treat 118:565-74. 2009
    ..On the other hand, we found that two SNPs in FASN were associated with BMI...
  65. ncbi Transcriptional regulation of 17beta-hydroxysteroid dehydrogenase type 12 by SREBP-1
    Shuji Nagasaki
    Department of Pathology, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Miyagi ken, Japan
    Mol Cell Endocrinol 307:163-8. 2009
    ..All these results obtained in this study clearly indicate that SREBP-1 represents one of the transcriptional regulators of human 17beta-HSD12...
  66. doi Role of NMDA receptor-dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries
    Changiz Taghibiglou
    Department of Medicine, Coastal Health Research Institute, University of British Columbia, Brain Research Centre, Vancouver, Canada
    Nat Med 15:1399-406. 2009
    ..Our study suggests that agents that reduce SREBP-1 activation such as Indip may represent a new class of neuroprotective therapeutics against stroke...
  67. pmc A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation
    Virginie Lecomte
    INSERM, U870, F 69921 Oullins Cedex, France
    Mol Cell Biol 30:1182-98. 2010
    ..In the present study, analysis of recent microarray data from muscle cells overexpressing SREBP1 suggested that they may play a role in the regulation of myogenesis...
  68. pmc MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis
    S Hani Najafi-Shoushtari
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Science 328:1566-9. 2010
    ..Our findings indicate that miR-33 acts in concert with the SREBP host genes to control cholesterol homeostasis and suggest that miR-33 may represent a therapeutic target for ameliorating cardiometabolic diseases...
  69. pmc Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
    Amy K Walker
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    Genes Dev 24:1403-17. 2010
    ..These findings may have important biomedical implications for the treatment of metabolic disorders associated with aberrant lipid/cholesterol homeostasis, including metabolic syndrome and atherosclerosis...
  70. pmc Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence
    You Mie Kim
    Department of Biochemistry and Molecular Biology, School of Medicine, Ajou University, Suwon 443 721, Korea
    J Biol Chem 285:29069-77. 2010
    ....
  71. pmc SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism
    Bhaskar Ponugoti
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 285:33959-70. 2010
    ..Reducing acetylation of SREBP-1c by targeting SIRT1 may be useful for treating metabolic disorders, including fatty liver, obesity, and type II diabetes...
  72. doi Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes
    Jorg Kotzka
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich Heine University Duesseldorf, Leibniz Center for Diabetes Research, Aufm Hennekamp 65, 40225 Duesseldorf, Germany
    Atherosclerosis 213:156-65. 2010
    ..In the regulation of lipid content of cells and tissues the SREBPs play a dominant role as transcription factors...
  73. doi Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes
    Céline Dubuquoy
    INSERM, U1016, Institut Cochin, Paris, France
    J Hepatol 55:145-53. 2011
    ..In order to understand the role of the adiponutrin/PNPLA3 protein, we investigated the regulation of its expression in both human and mouse hepatocytes...
  74. doi Associations of the SREBP-1c gene polymorphism with gender-specific changes in serum lipids induced by a high-carbohydrate diet in healthy Chinese youth
    Zhen Zhang
    Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine and State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China
    Appl Physiol Nutr Metab 36:226-32. 2011
    ....
  75. doi Identification of a gene variant in the master regulator of lipid metabolism SREBP-1 in a family with a novel form of severe combined hypolipidemia
    Jorg Kotzka
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at Heinrich Heine University Duesseldorf, Leibniz Center for Diabetes Research, Aufm Hennekamp 65, 40225 Duesseldorf, Germany
    Atherosclerosis 218:134-43. 2011
    ..Variation of gene structure in these genes might therefore indicate a predisposition to develop complications like myocardial infarction and stroke...
  76. pmc Activation of androgen receptor, lipogenesis, and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells
    Wen Chin Huang
    Uro Oncology Research Program, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Mol Cancer Res 10:133-42. 2012
    ....
  77. pmc Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass
    Birgit Knebel
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich Heine University Duesseldorf, Duesseldorf, Germany
    PLoS ONE 7:e31812. 2012
    ....
  78. pmc Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis
    Weihua Li
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, China
    Cell Cycle 11:2348-58. 2012
    ..The sterol regulatory element-binding protein 1 (SREBP1), encoded by SREBF1 gene, is a master regulator of lipogenic gene expression...
  79. doi [Association of sterol regulatory element binding protein-1c genetic polymorphisms rs2297508 and rs11868035 with type 2 diabetes mellitus in Gansu Han and Dongxiang population]
    Ju Xiang Liu
    Department of Endocrinology, People s Hospital of Gansu Province, Lanzhou, Gansu 730000, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:328-33. 2012
    ..To assess the association between single nucleotide polymorphisms (SNP) rs2297508 and rs11868035 of sterol regulatory element binding protein-1c (SREBP-1c) gene and type 2 diabetes mellitus (T2DM) in Han and Dongxiang populations in Gansu...
  80. doi Sterol regulatory element-binding protein 1 is required for ovarian tumor growth
    Long Yun Nie
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan 250012, P R China
    Oncol Rep 30:1346-54. 2013
    ..of lipogenic enzymes, most of which are transcriptional targets of sterol regulatory element-binding protein 1 (SREBP1). However, the expression levels and the function of SREBP1 in ovarian cancer are largely unknown...
  81. ncbi Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2)
    A R Miserez
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Genomics 40:31-40. 1997
    ..b>SREBP1 and SREBP2 share approximately 47% sequence identity and map to chromosomes 17 and 22, respectively...
  82. pmc Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors
    Valeria Giandomenico
    Ludwig Institute for Cancer Research, S 751 24 Uppsala, Sweden
    Mol Cell Biol 23:2587-99. 2003
    ..In SREBP1a, the acetylated lysine residue resides in the DNA-binding domain of the protein...
  83. ncbi Sterol regulatory element-binding protein-1 mediates the effect of insulin on hexokinase II gene expression in human muscle cells
    Yvan Gosmain
    Unité Mixte de Recherche Institut National de la Santé et de la Recherche Médicale INSERM Unit 449 Institut National de la Recherche Agronomique Unit 1235, Faculté de Médecine René Laennec, Universite Claude Bernard Lyon, Lyon, France
    Diabetes 53:321-9. 2004
    ..These results demonstrate that SREBP-1c is involved in the effect of insulin on HKII gene transcription and indicate that it is one of the mediators of insulin action on gene expression in human skeletal muscle...
  84. ncbi Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism
    Lingfang Zeng
    Division of Biomedical Sciences, University of California, Riverside, Riverside, California 92521, USA
    J Biol Chem 279:48801-7. 2004
    ..Thus, this SREBP-regulated mechanism may control the efflux of cholesterol, which is a newly defined function of SREBP2 in ECs in addition to its role in cholesterol uptake and biosynthesis...
  85. ncbi Determinants of variable response to simvastatin treatment: the role of common variants of SCAP, SREBF-1a and SREBF-2 genes
    M Fiegenbaum
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, 91501 970 Porto Alegre, RS, Brazil
    Pharmacogenomics J 5:359-64. 2005
    ..8%), whereas only 29% of 2386A homozygous reached this reduction (P=0.009). Our data suggest that the SCAP 2386A>G gene polymorphism was a significant predictor of TC and triglyceride responses to simvastatin treatment...
  86. pmc Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes
    A H Harding
    MRC Epidemiology Unit, Cambridge, UK
    Diabetologia 49:2642-8. 2006
    ..The present study aimed to replicate our previously reported association in a larger case-control study and to examine an additional five SREBF1c SNPs for their association with diabetes risk and plasma glucose concentrations...
  87. ncbi DAX-1 represses the high-density lipoprotein receptor through interaction with positive regulators sterol regulatory element-binding protein-1a and steroidogenic factor-1
    D Lopez
    Department of Obstetrics and Gynecology, University of South Florida, Tampa, Florida 33606, USA
    Endocrinology 142:5097-106. 2001
    ....
  88. ncbi Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1
    Svanhild A Schønberg
    Department of Laboratory Medicine, Children s and Women s Health, Norwegian University of Science and Technology, Trondheim, Norway
    FEBS J 273:2749-65. 2006
    ..Our results demonstrate cell-specific mechanisms for the processing and storage of cytotoxic PUFAs in closely related cell lines, and suggest downregulation of nSREBP1 as a possible contributor to the growth inhibitory effect of DHA...
  89. ncbi Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells
    Patrizia Rise
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Eur J Pharmacol 571:97-105. 2007
    ..These results taken together suggest that SREBP-1 is involved in the early regulation of delta5 desaturase gene by simvastatin, in THP-1 cells...
  90. doi Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1
    Eiji Furuta
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9626, USA
    Cancer Res 68:1003-11. 2008
    ....
  91. pmc Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit
    Yoshinori Takeuchi
    Laboratory of Molecular Physiology on Energy Metabolism, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Biol Chem 285:11681-91. 2010
    ..The mechanisms for PUFA suppression of SREBP-1 confirm that the autoloop regulation for transcription is crucial for the nutritional regulation of triglyceride synthesis...
  92. doi Triglycerides and gallstone formation
    A H M Smelt
    Department of General Internal Medicine, Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands
    Clin Chim Acta 411:1625-31. 2010
    ..The question remains whether improvement of gallbladder motility and increased lithogenicity of bile by bezafibrate therapy counteract each other or still result in gallstone formation in HTG patients...
  93. ncbi Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
    Motoyuki Kohjima
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 812 8582 Fukuoka, Japan
    Int J Mol Med 20:351-8. 2007
    ..Further studies will be needed to clarify how fatty acid synthesis is increased by SREBP-1c, which is under the control of insulin and AMP-activated protein kinase...
  94. ncbi Regulation of sterol regulatory element-binding proteins in hamster intestine by changes in cholesterol flux
    F J Field
    Department of Internal Medicine and Department of Veterans Affairs, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 276:17576-83. 2001
    ..Following marked changes in cholesterol flux across the intestine, SREBP-2 assumes the role of SREBP-1 and regulates both cholesterol and fatty acid synthesis in intestine...
  95. ncbi Regulation of sterol regulatory element-binding proteins by cholesterol flux in CaCo-2 cells
    F J Field
    Department of Internal Medicine, 4 522 JCP, 200 Hawkins Drive, and Veterans Administration, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Lipid Res 42:1687-98. 2001
    ..In contrast, 25-hydroxycholesterol influx or cholesterol depletion alters the amount of mature SREBP, leading to the regulation of sterol-responsive gene expression...
  96. ncbi Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis
    C J Carter
    Neurochem Int 50:12-38. 2007
    ..Am. J. Hum. Genet. 78, 464-479.]. Thus, the fact that Alzheimer's disease susceptibility genes converge on a clearly defined signaling network has important implications for genetic association studies...
  97. ncbi Nelfinavir induces liposarcoma apoptosis and cell cycle arrest by upregulating sterol regulatory element binding protein-1
    Warren A Chow
    Department of Medical Oncology and Therapeutics Research, City of Hope Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Anticancer Drugs 17:891-903. 2006
    ..Our data indicate that nelfinavir represents a novel class of antiliposarcoma agent that acts by selectively upregulating sterol regulatory element binding protein-1 expression in liposarcomas...
  98. ncbi Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?
    Javier A Menendez
    Department of Medicine, Evanston Northwestern Healthcare Research Institute, 1001 University Place, Evanston, IL 60201, USA
    Med Hypotheses 64:342-9. 2005
    ....
  99. ncbi Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARalpha target genes in rat liver
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, D 06108 Halle Saale, Germany
    J Nutr 137:77-83. 2007
    ..This study shows that OF prevents an alcohol-induced triacylglycerol accumulation in rats possibly by upregulation of hepatic PPARalpha-responsive genes involved in oxidation of fatty acids, whereas CLA does not exert such an effect...
  100. doi Effects of bovine fatty acid synthase, stearoyl-coenzyme A desaturase, sterol regulatory element-binding protein 1, and growth hormone gene polymorphisms on fatty acid composition and carcass traits in Japanese Black cattle
    T Matsuhashi
    Gifu Prefectural Livestock Research Institute, Kiyomi, Takayama, Gifu 506 0101, Japan
    J Anim Sci 89:12-22. 2011
    ..the bovine fatty acid synthase (FASN), stearoyl-CoA desaturase (SCD), sterol regulatory element-binding protein 1 (SREBP1), and GH genes...
  101. ncbi Sterol regulatory element-binding protein-1 interacts with the nuclear thyroid hormone receptor to enhance acetyl-CoA carboxylase-alpha transcription in hepatocytes
    Liya Yin
    Department of Biochemistry and Molecular Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia 26506, USA
    J Biol Chem 277:19554-65. 2002
    ..Here, we also show that alterations in SREBP expression play a role in mediating cell type-dependent differences in T3 regulation of ACCalpha transcription...

Research Grants74

  1. Role of Stearoyl-CoA Desaturase in Metabolism
    James M Ntambi; Fiscal Year: 2010
    ..We have discovered a mechanism that partitions fat away from storage towards its burning in the fed state. Our research will contribute to the treatment of human obesity, diabetes and other metabolic diseases. ..
  2. Jeffrey E Pessin; Fiscal Year: 2016
    ....
  3. Marshall B Elam; Fiscal Year: 2014
    ..Understanding how PUFA causes this will lead to more effective treatments for high triglyceride levels in individuals with obesity and type II diabetes to reduce risk of heart attack and stroke. ..
  4. Min You; Fiscal Year: 2016
    ..liver in mice by affecting several important liver transcription factors and co-factors;namely, sterol regulatory element binding protein 1 (SREBP-1), peroxisome proliferator-activated receptor alpha (PPAR-alpha) and PPAR-gamma co-..
  5. Regulation of SREBP-1c Processing by Insulin and Cyclic-AMP
    Marshall B Elam; Fiscal Year: 2010
    ..The goal of this research is to identify new treatments for hyperlipidemia by understanding the mechanisms by which insulin regulates this protein. ..
  6. Sudha B Biddinger; Fiscal Year: 2015
    ..We expect to find that FoxO1 and SREBP-1c define two distinct metabolic signaling pathways that are both necessary for the full complement of derangements present in the metabolic syndrome. ..
  7. Vsevolod Y Polotsky; Fiscal Year: 2014
    ..abstract_text> ..
  8. Alcohol-Induced Fatty Liver and Injury in Humanized CYP2E1 Knockin Mice.
    Arthur I Cederbaum; Fiscal Year: 2011
    ..Identification of downstream effectors of alcohol/CYP2E1 actions would be very informative in developing therapeutic interventions against alcohol-induced liver injury and fatty liver. ..
  9. JOSHUA JAMES ZIAREK; Fiscal Year: 2014
    ..Our results may also provide a structural basis for abnormal SREBP activity and benefit drug discovery efforts aimed at inhibiting aberrant SREBP signaling. ..
  10. Terry G Unterman; Fiscal Year: 2016
    ..Additional studies are planned to investigate specific mechanisms mediating effects of FoxO proteins on gene expression and metabolism in the liver. ..
  11. Robert V Farese; Fiscal Year: 2016
    ..abstract_text> ..
  12. Robert Farese; Fiscal Year: 2014
    ..We are confident that the proposed studies will provide a new approach for effective treatment of O/MS and T2DM. ..
  13. THERAPEUTIC APPROACHES FOR NEURODEGENERATION CAUSED BY PLA2G6 MUTATIONS
    Paul T Kotzbauer; Fiscal Year: 2012
    ....
  14. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..The greatest potential for arresting this epidemic is likely to come through a clearer understanding of its molecular pathogenesis to develop rational and mechanism based therapy. ..
  15. RYAN EUGENE TEMEL; Fiscal Year: 2016
    ..These studies will greatly aid in assessing anti-miR-33 as a potential clinical treatment for CHD. ..
  16. Deliang Guo; Fiscal Year: 2016
    ....
  17. Fajun Yang; Fiscal Year: 2015
    ....
  18. Shunlin Ren; Fiscal Year: 2016
    ....
  19. Timothy F Osborne; Fiscal Year: 2016
    ....
  20. Lipogenic inhibitors in prevention of oncogene induced liver cancer
    Xin Chen; Fiscal Year: 2013
    ..of lipogenic pathway inhibitors including C-75 (FASN inhibitor), simvastatin (MHGCR inhibitor) and Fatostatin (SREBP1/2 inhibitor) in c-Myc induced mouse HCC...
  21. REUBEN JAMES SHAW; Fiscal Year: 2015
    ..and study of a number of novel AMPK substrates critical in metabolism, including Raptor, ULK1, Cry1, Srebp1, and HDACs4, 5, and 7...
  22. Inhibition of S14 by Conjugated Linoleic Acid in Advanced Solid Tumor Patients
    Raymond P Perez; Fiscal Year: 2010
    ..Secondary molecular endpoints include other lipogenic and lipolytic enzymes (such as FAS), SREBP1, phospho-AKT, biomarkers of cell-cycle/proliferation (Ki67, geminin), and apoptosis (cleaved caspase 3)...
  23. Bo Qiu; Fiscal Year: 2015
    ..Thus, my second hypothesis (AIM2) is that HIF-2[unreadable]-mediated TGF-[unreadable] expression activates SREBP1-dependent de novo lipogenesis to support tumor cell viability and proliferation...
  24. Dissection of SREBP/ATF6 crosstalk in alcohol-induced steatosis
    Deanna L Howarth; Fiscal Year: 2013
    ..The first aim of this proposal assesses the individual and combined roles of Srebp1, Srebp2, and Atf6 to induce alcoholic steatosis...
  25. Air/liquid interface cultures for alveolar type II cell differentiation
    ROBERT JAMES MASON; Fiscal Year: 2012
    ..This study should also indicate that sustained pulmonary edema will impair type I cell function and provide another reason for the use of supplemental oxygen in acute lung injury. ..
  26. Steven J Bensinger; Fiscal Year: 2015
    ..In this application, we test the hypothesis that the Sterol Response Element Binding Proteins (SREBP1 and 2), key transcriptional regulators of lipid biosynthesis and homeostasis, play a critical role in linking ..
  27. CONTROL OF GENE TRANSCRIPTION BY ESSENTIAL FATTY ACIDS
    Thomas Gettys; Fiscal Year: 2005
    ..The proposed research continues our efforts to identify molecular targets that can be manipulated by diet or drugs for the purpose of reducing cellular lipid accumulation and hence lessen a complication of diabetes. ..
  28. HORMONAL AND NUTRITIONAL CONTROL OF ENZYME BIOSYNTHESIS
    Hei Sook Sul; Fiscal Year: 2004
    ....
  29. Synthetic LXRbeta Ligands in the Treatment of Alzheimer's Disease
    BARRY FORMAN; Fiscal Year: 2007
    ..Using these lead compounds we propose a series of chemical syntheses to optimize this lead and ultimately to test the efficacy of LXRb-selective ligands in vitro and in a mouse model of AD. [unreadable] [unreadable] [unreadable]..
  30. The role of insulin signaling in the dyslipidemia of the metabolic syndrome
    Sudha B Biddinger; Fiscal Year: 2010
    ..These studies will identify urgently needed targets for reversing the dyslipidemia of the metabolic syndrome. ..
  31. Alveolar Type II Cells in vitro: Effect of KGF
    Robert Mason; Fiscal Year: 2009
    ..In the future, such drugs could be used to treat acute lung injury, acute respiratory distress syndrome, respiratory distress of the newborn, severe pneumonias and diseases of small airways such as asthma. ..
  32. Cholesterol transport regulation in cystic fibrosis
    Thomas Kelley; Fiscal Year: 2007
    ..Aim 3. To examine isoprenoid/cholesterol synthesis and sterol regulatory element binding protein-1 (SREBP-1a and SREBP-1c) and SREBP-2 regulation in CF cells. [unreadable] [unreadable]..
  33. Regulation and function of SREBP-1c in skeletal muscle
    MICHAEL BIZEAU; Fiscal Year: 2004
    ..This research experience will allow the candidate to compete for R01 funding and establish an independent research career. ..
  34. ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIET
    Martin Ronis; Fiscal Year: 2005
    ....
  35. ABCs of Intestinal Sterol Transport
    F Field; Fiscal Year: 2009
    ..The results of this proposal will provide new and novel information on the roles of the ABC transporters, NPC1L1, and lipid rafts in intestinal sterol metabolism ..
  36. NON-PARENCHYMAL LIVER CELL CORE
    Hidekazu Tsukamoto; Fiscal Year: 2005
    ..abstract_text> ..
  37. PATHOGENESIS OF ALCOHOL LIVER INJURY
    Hidekazu Tsukamoto; Fiscal Year: 2003
    ....
  38. Iron Signaling/Monocytes/Alcoholic Hepatitis Patients
    Hidekazu Tsukamoto; Fiscal Year: 2005
    ..In summary, the current proposal is the first exploratory study to test dysregulation of the novel [LMW-Fe]I signaling in AH patients as the molecular basis for heightened TNFalpha expression. ..
  39. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2006
    ..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
  40. Epigenetic mechanism of HSC transdifferentiation in alcoholic liver fibrosis
    Hidekazu Tsukamoto; Fiscal Year: 2007
    ..Kazuo Ikeda, a developer of this system. This exploratory study will be first to disclose epigenetic regulation of HSC transdifferentiation in ALF. [unreadable] [unreadable] [unreadable]..
  41. Conference:Lung Surfactant:Cellular & Molecular Biology
    Robert Mason; Fiscal Year: 2002
    ..abstract_text> ..
  42. Transcriptional Regulation of SREBP-1c by Dietary Polyunsaturated Fatty Acids
    George Howell; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  43. FAT MEDIATED INSULIN SECRETION AND DIABETES IN ELDERLY
    Guenther Boden; Fiscal Year: 2003
    ..We hope that this project will help to better understand the mechanisms by which obesity contributes to the development of NIDDM. ..
  44. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  45. INSULIN & GLUCOSE SIGNALING PATHWAYS IN ISLET BETA CELLS
    Rohit Kulkarni; Fiscal Year: 2004
    ....
  46. Insulin Control of Fat Regulation and Exercise in Teens
    Kristen Nadeau; Fiscal Year: 2008
    ..The K-23 application will help me reach my long-term goal of being an independent investigator in the field of pediatric insulin resistance and type 2 diabetes. ..
  47. Effects of chemopreventive agents on DNA damage response
    J Christopher States; Fiscal Year: 2006
    ..The results will likely illuminate a chemoprevention mechanism and also provide a deeper understanding of the mechanism of DNA damage and repair under a more physiologically relevant environmental exposure dose. ..
  48. Dissecting the Death Pathway in Islet Beta Cells
    Rohit Kulkarni; Fiscal Year: 2005
    ..abstract_text> ..
  49. Fat Induced Insulin Resistance and Atherosclerosis
    Guenther Boden; Fiscal Year: 2007
    ..We believe that these studies will provide important new information relative to the mechanism by which obesity and FFAs cause IR and ASVD in human subjects. ..
  50. Integrated Regulation of Bile Acids and Diabetes
    Timothy F Osborne; Fiscal Year: 2010
    ..Here, we plan to use both pharmacological and genetic manipulation to evaluate PGC-1alpha in regulation of CYP7A1 expression, bile acid metabolism, and hepatic glucose metabolism. ..
  51. NEUROBIOLOGICAL FACTORS IN ADOLESCENT ALCOHOL DRINKING
    William McBride; Fiscal Year: 2009
    ..Such information could be helpful in developing useful strategies for combating the major problem of adolescent alcohol drinking. ..
  52. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  53. A COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
    John Rice; Fiscal Year: 2007
    ..Analysis of the existing sib pair families plus this large set of cases and controls should permit the confirmation of several vulnerability genes during this grant period. ..
  54. INDUCTION OF MAMMARY CANCER BY SIGNALING MOLECULES
    Steven Anderson; Fiscal Year: 2003
    ..These studies will provide new information about the effect of the prolactin receptor upon mammary epithelial cells, and whether suppression of apoptosis in Important in mammary carcinogenesis. ..
  55. Leptin modulation of insulin action in the islet b-cell
    Rohit Kulkarni; Fiscal Year: 2005
    ..abstract_text> ..
  56. Involvement of Aldehydes in Alcohol Addiction
    William McBride; Fiscal Year: 2002
    ..Such results could provide valuable information on novel mechanisms underlying the addictive properties of alcohol and would provide a firm scientific foundation for future neurobiological studies. ..
  57. Taskforce for Obesity Research at Southwestern (RMI)
    JAY HORTON; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  58. Insulin Resistance and ABCA1 Transporter Function
    WILLIAM GARVER; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  59. Pathogenesis of Obesity and Metabolic Syndrome
    JAY HORTON; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  60. Arsenic Induced Miotic Arrest Associated Apoptosis
    J Christopher States; Fiscal Year: 2009
    ....
  61. Characterization of Microsomal Fatty Acid Elongation
    JAY HORTON; Fiscal Year: 2007
    ..abstract_text> ..
  62. COLLABORATIVE DEPRESSION STUDY
    John Rice; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  63. A Molecular Marker for Cardiac Autonomic Dysfunction
    Ho Jin Park; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  64. Involvement of Aldehydes in Alcohol Addiction
    William McBride; Fiscal Year: 2009
    ..Understanding the contribution of ACD and THIQs to high alcohol drinking could lead to the development of novel pharmaco-therapies for the treatment of alcoholism and alcohol abuse ..
  65. DIETARY FAT REGULATION OF HEPATIC GENE EXPRESSION
    DONALD JUMP; Fiscal Year: 2009
    ..Determine how over expression of specific fatty acid elongases affects hepatic function, blood lipid composition and the onset of chronic disease. ..
  66. Identification of Genes Activated by Bile Acids
    Peter Edwards; Fiscal Year: 2009
    ..In addition, these studies will elucidate the role of FXR in glucose, steroid and drug metabolism and in resistance to endotoxin. ..
  67. Neurobiology of high alcohol-seeking behavior
    WILLIAM JOSEPH MCBRIDE; Fiscal Year: 2010
    ....