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Genomes and Genes
| SrcSummaryGene Symbol: Src Description: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) Alias: ASV, SRC1, c-SRC, p60-Src, proto-oncogene c-Src, proto-oncogene tyrosine-protein kinase Src, protooncogene SRC, Rous sarcoma, tyrosine kinase pp60c-src, tyrosine-protein kinase SRC-1 Species: human Top Publications
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Publications
Properties of tripartite chimeras between Src and LckA Kashishian
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
Oncogene 5:1463-70. 1990To evaluate the possible regulatory effects of interactions between different domains of Src-family kinases, we have assembled five chimeric molecules containing parts of p60c-src (Src) and p56lck (Lck)...- Identification of Itk/Tsk Src homology 3 domain ligandsS C Bunnell
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
J Biol Chem 271:25646-56. 1996..SH3 domains to interact with deletion variants of Sam 68 and WASP, we demonstrated that the Itk-SH3 domain and the SH3 domains of Src family kinases bind to overlapping but distinct sets of proline-rich regions in Sam 68 and WASP. 
Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinasesC Hugh Reynolds
The MRC Centre for Neurodegeneration Research, King s College London, Institute of Psychiatry, London, UK
J Biol Chem 283:18177-86. 2008..protein tau can associate with various other proteins in addition to tubulin, including the SH3 domains of Src family tyrosine kinases...- Activating SRC mutation in a subset of advanced human colon cancersR B Irby
Department of Surgery, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa 33612, USA
Nat Genet 21:187-90. 1999The discovery of Rous sarcoma virus (RSV) led to the identification of cellular Src (c-Src), a non-receptor tyrosine kinase, which has since been implicated in the development of numerous human cancers... - TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-SrcB R Wong
Laboratory of Immunology, Rockefeller University, New York, New York 10021, USA
Mol Cell 4:1041-9. 1999..that TRANCE activates the antiapoptotic serine/threonine kinase Akt/PKB through a signaling complex involving c-Src and TRAF6... - Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activationW Cao
Departments of Psychiatry and Behavioral Sciences, Pharmacology, and Medicine and the Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 275:38131-4. 2000..We previously showed that c-Src is required for ERK activation by beta(2)AR and that it is recruited to activated beta(2)AR through binding of the .. 
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinasesM B Calalb
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
Mol Cell Biol 15:954-63. 1995..implicated in integrin-mediated signal transduction pathways and in the process of oncogenic transformation by v-Src. Elevation of FAK's phosphotyrosine content, following both cell adhesion to extracellular matrix substrata and ..- Role of c-Src in human MCF7 breast cancer cell tumorigenesisLorena Gonzalez
Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Madrid, Spain
J Biol Chem 281:20851-64. 2006To study the role of c-Src in breast cancer tumorigenesis, we generated a cell line derived from MCF7 carrying an inducible dominant negative c-Src (c-SrcDN: K295M/Y527F) under tetracycline control (Tet-On system)... - Stat3 activation by Src induces specific gene regulation and is required for cell transformationJ Turkson
H Lee Moffitt Cancer Center and Research Institute, and Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa 33612, USA
Mol Cell Biol 18:2545-52. 1998..constitutively elevated tyrosine phosphorylation and DNA-binding activity in fibroblasts stably transformed by the Src oncoprotein... - Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancerMaricarmen D Planas-Silva
Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA
Biochem Biophys Res Commun 341:73-81. 2006The non-receptor tyrosine kinases c-Src and focal adhesion kinase (Fak) mediate signal transduction pathways that regulate cell proliferation, survival, invasion, and metastasis... - p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2Isabel Chu
Braman Family Breast Cancer Institute of the University of Miami Sylvester Comprehensive Cancer Center and Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Cell 128:281-94. 2007..Here, we present data indicating that the oncogenic kinase Src regulates p27 stability through phosphorylation of p27 at tyrosine 74 and tyrosine 88... - Regulation of arrestin-3 phosphorylation by casein kinase IIYou Me Kim
Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Biol Chem 277:16837-46. 2002..states of arrestin-3 promote beta(2)-adrenergic receptor internalization and bind clathrin, beta-adaptin, and Src to comparable levels as wild type arrestin-3... - Hydrogen peroxide activates focal adhesion kinase and c-Src by a phosphatidylinositol 3 kinase-dependent mechanism and promotes cell migration in Caco-2 cell monolayersShyamali Basuroy
Department of Physiology, University of Tennessee Health Science Center, 894 Union Ave, Memphis, TN 38163, USA
Am J Physiol Gastrointest Liver Physiol 299:G186-95. 2010Recent studies showed that c-Src and phosphatidylinositol 3 (PI3) kinase mediate the oxidative stress-induced disruption of tight junctions in Caco-2 cell monolayers... - Activation and association of Stat3 with Src in v-Src-transformed cell linesX Cao
Signal Transduction Laboratory, Institute of Molecular and Cell Biology, National University of Singapore
Mol Cell Biol 16:1595-603. 1996..Stat3 is also activated by CSF-1, possibly through CSF-1 receptor-c Src association in NIH 3T3 cells overexpressing CSF-1 receptors... - MUC1 initiates Src-CrkL-Rac1/Cdc42-mediated actin cytoskeletal protrusive motility after ligating intercellular adhesion molecule-1Qiang Shen
Department of Laboratory Medicine and Pathology, 5B4 21 Mackenzie Health Sciences Centre, University of Alberta Hospital, Edmonton, AB, Canada T6G 2R7
Mol Cancer Res 6:555-67. 2008..Further, we show that these MUC1/ICAM-1 interaction-initiated lamellipodial and filopodial protrusions require Src family kinase and CT10 regulator of kinase like (CrkL) accompanied by the rapid formation of a Src-CrkL signaling .. - Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascadeS C Bunnell
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Biol Chem 275:2219-30. 2000..Second, the Itk proline-rich region binds to Grb2 and LAT. Third, the Itk Src homology (SH3) 3 and SH2 domains interact cooperatively with Syk-phosphorylated SLP-76... - PTP1B contributes to the oncogenic properties of colon cancer cells through Src activationShudong Zhu
Department of Biochemistry and Molecular Biology, and Southern Alberta Cancer Research Institute, University of Calgary, Calgary, Alberta, Canada
Cancer Res 67:10129-37. 2007b>Src-specific activity has been reported to be elevated in a high percentage of colon cancer cell lines and tumors, but the underlying mechanisms are largely unknown... - Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, SinK Alexandropoulos
Massachusetts Institute of Technology, Cambridge, 02139, USA
Genes Dev 10:1341-55. 1996To understand how protein-protein interactions mediated by the Src-SH3 domain affect c-Src signaling, we screened for proteins that interact with the Src-SH3... - The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutantsB M Chung
Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, 68198 6805, USA
Oncogene 28:1821-32. 2009..the possibility that the ability of mutant EGFRs to transform cells reflects a constitutive cooperativity with Src using a system in which the overexpression of mutant, but not wild-type, EGFR induced anchorage-independent cell .. - TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic SrcKent Z Q Wang
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Cell Sci 119:1579-91. 2006..It was observed that PI 3-kinase was activated either by treatment with IL-1 or by expression of either TRAF6, Src, MyD88 or dominant-positive PI 3-kinase, and resulted in the formation of long filopodia-like cellular protrusions .. - Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathwayM W Wooten
Department of Biological Sciences, Auburn University, 331 Funchess Hall, Auburn, AL 36849, USA
Mol Cell Biol 21:8414-27. 2001..phosphorylation and activation of PKC-iota were inhibited in a dose-dependent manner by both PP2 and K252a, src and TrkA kinase inhibitors. Purified src was observed to phosphorylate and activate PKC-iota in vitro... - Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 bindingBanibrata Sen
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
Cancer Res 69:1958-65. 2009..One promising molecular target in HNSCC is the Src family kinases (SFK)... - c-Src regulates constitutive and EGF-mediated VEGF expression in pancreatic tumor cells through activation of phosphatidyl inositol-3 kinase and p38 MAPKJustin M Summy
University of Texas MD Anderson Cancer Center, Department of Cancer Biology, Houston, TX 77054, USA
Pancreas 31:263-74. 2005..aberrantly activated and/or overexpressed in pancreatic tumors, including the nonreceptor protein tyrosine kinase Src. The goal of this study was to determine the role of Src in regulating VEGF expression and angiogenic potential in .. - Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinaseYi Wu
Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, Tamaho, Nakakoma, Yamanashi, Japan
Blood 101:3469-76. 2003..Recent studies have implied that activation of Src family kinases is involved in GPIb-mediated platelet activation, although the related signal transduction pathway .. - Ret-mediated mitogenesis requires Src kinase activityR M Melillo
Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita di Napoli Federico II, Naples, Italy
Cancer Res 59:1120-6. 1999..TKs results in the binding and activation of downstream signaling proteins, among which are nonreceptor TKs of the Src family... - A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent mannerR Sakai
Molecular Biology Division, Jichi Medical School, Tochigi, Japan
EMBO J 13:3748-56. 1994p47v-crk (v-Crk), a transforming gene product containing Src homology (SH)-2 and -3 domains, induces an elevated level of tyrosine phosphorylation of several cellular proteins... - Signal transducers and activators of transcription-3 binding to the fibroblast growth factor receptor is activated by receptor amplificationAnna A Dudka
CRUK Growth Factor Group, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
Cancer Res 70:3391-401. 2010..Tyrosine phosphorylation of STAT3 was also dependent on concomitant FGFR-dependent activity of SRC and JAK kinases... - Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1Zhongjian Xie
Endocrine Unit, Veterans Affairs Medical Center, Northern California Institute for Research and Education and University of California San Francisco, San Francisco, CA 94121, USA
Mol Biol Cell 16:3236-46. 2005..In the present study, we investigated whether the activation of PLC-gamma1 by nonreceptor kinases such as src and fyn plays a role in mediating this process... - ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinasesM A Olayioye
Friedrich Miescher Institute, P O Box 2543, CH 4002 Basel, Switzerland
J Biol Chem 274:17209-18. 1999..However, we provide evidence that EGF- and neu differentiation factor-induced Stat activation are dependent on Src but not Jak kinases. Upon EGF stimulation, c-Src was rapidly recruited to Stat/ErbB receptor complexes... - Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor featuresMahitosh Mandal
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Cancer 112:2088-100. 2008..In the current study, the expressions of several factors associated with the induction of EMT in HNSC cell lines and tumor specimens were investigated to define their functional and pathologic role in HNSC... - Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassemblyQin Feng
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Mol Cell Biol 26:7846-57. 2006..Steroid receptor coactivator 3 (SRC-3) coactivator phosphorylation has been shown to regulate coactivator complex assembly, but the mechanisms by which .. - Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expressionWei Chien Huang
Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
J Immunol 170:4767-75. 2003..A protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or a Src kinase inhibitor (PP2) attenuated TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 promoter .. - Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patientsKan V Lu
Department of Pathology and Laboratory Medicine, University of California Los Angeles David Geffen School of Medicine, USA
Cancer Res 69:6889-98. 2009..However, clinical responses to EGFR inhibitors are infrequent and short-lived. We show that the Src family kinases (SFK) Fyn and Src are effectors of oncogenic EGFR signaling, enhancing invasion and tumor cell .. - c-Src/histone deacetylase 3 interaction is crucial for hepatocyte growth factor dependent decrease of CXCR4 expression in highly invasive breast tumor cellsEmanuela Matteucci
Institute of General Pathology, School of Medicine, University of Milan, via Luigi Mangiagalli, 31 20133 Milan, Italy
Mol Cancer Res 5:833-45. 2007..invasive) breast carcinoma cells, and here, we show that completely different molecular mechanisms downstream of c-Src activation were involved... - c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cellsCatherine M Waters
Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow G4 ONR, UK
Cell Signal 17:263-77. 2005..We now demonstrate that c-Src participates in regulating the endocytosis of PDGFbeta receptor-GPCR complexes in response to PDGF... - Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complexYong Bae Kim
Department of Tumor Biology, Cancer Research Institute, Cell Dynamics Research Center, College of Medicine, Seoul National University, Seoul 110 799, Korea
J Biol Chem 283:10089-96. 2008..with suspended cells, fibronectin-adherent cells showed enhanced pS(3)cofilin, depending on ILK expression and c-Src activity... - Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cellsT B van Dijk
Institute of Hematology, Erasmus University Rotterdam, Rotterdam, The Netherlands
Blood 96:3406-13. 2000..These findings suggest that p62Dok-1 may function as an important scaffold molecule in cKit-mediated signaling... - Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activityJ Park
Friedrich Miescher Institute, Maulbeerstrasse 66, Basel CH 4058, Switzerland
J Biol Chem 276:37459-71. 2001..Both of these residues can be phosphorylated by v-Src tyrosine kinase in vitro, and co-expression of v-Src leads to tyrosine phosphorylation and activation of PDK1... - Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolinM A Chellaiah
Department of Oral and Craniofacial Biological Sciences, University of Maryland, 666 W Baltimore St, Baltimore, MD 21201, USA
J Biol Chem 276:47434-44. 2001..Here we show that gelsolin coprecipitates some of the focal adhesion-associated proteins such as c-Src, phosphoinositide 3-kinase (PI3K), p130(Cas), focal adhesion kinase, integrin alpha(v)beta(3), vinculin, talin, and .. - Identification of preferred protein interactions by phage-display of the human Src homology-3 proteomeSatu Kärkkäinen
Institute of Medical Technology, University of Tampere and Tampere University Hospital, Biokatu 8, Tampere 33014, Finland
EMBO Rep 7:186-91. 2006We have determined the human genome to contain 296 different Src homology-3 (SH3) domains and cloned them into a phage-display vector... - Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-kappaB activationYa Jen Chang
Department of Pharmacology, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei, Taiwan
Mol Pharmacol 66:1465-77. 2004..Phosphatidylinositol-specific phospholipase C (PI-PLC), protein kinase C (PKC), and Src inhibitors inhibited COX-2 induction... - Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeletonAchim Obergfell
Division of Vascular Biology, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Cell Biol 157:265-75. 2002..We find here that Src associates constitutively with integrin alphaIIbbeta3 in platelets... - Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathwayJohn R Basile
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Mol Cell Biol 25:6889-98. 2005..the activation of an intracellular tyrosine kinase cascade that involves the sequential activation of PYK2 and Src. This results in the tyrosine phosphorylation of Plexin-B1, the rapid recruitment of a multimeric signaling complex .. - Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosisMarisa Dolled-Filhart
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Clin Cancer Res 9:594-600. 2003.... - Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and phosphatidylinositol 3-kinase pathwaysJuan J Acosta
Instituto de Investigaciones Biomédicas A Sols, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
Mol Endocrinol 17:2268-82. 2003..Here we studied the role of c-Src on PRL-stimulated proliferation of T47D and MCF7 breast cancer cells... - Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by SrcM B Calalb
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biochem Biophys Res Commun 228:662-8. 1996..The major autophosphorylation site is tyrosine-397, which interacts with the Src homology 2 (SH2) domain of Src-family kinases including Src and Fyn... - Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteinsV J Fincham
Beatson Institute for Cancer Research, CRC Beatson Laboratories, Glasgow, Scotland
J Cell Biol 135:1551-64. 1996We have isolated Swiss 3T3 subclones that are resistant to the mitogenic and morphological transforming effects of v-Src as a consequence of aberrant translocation of the oncoprotein under low serum conditions... - Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell linesJ D Bjorge
Cancer Biology Research Group, Department of Biochemistry and Molecular Biology, University of Calgary Health Sciences Centre, Calgary, Alberta T2N 4N1, Canada
J Biol Chem 275:41439-46. 2000c-Src tyrosine kinase activity is elevated in several types of human cancer, and this has been attributed to elevated c-Src expression levels, increased c-Src specific activity, and activating mutations in c-Src... - Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5bElena B Kabotyanski
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
J Biol Chem 278:17218-27. 2003Stat5 is activated by a broad spectrum of cytokines, as well as non-receptor tyrosine kinases, such as Src. In this study, the DNA binding properties of the two closely related Stat5 proteins, Stat5a and Stat5b, induced either by .. - Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communicationB N Giepmans
Division of Cellular Biochemistry, The Netherlands Cancer Institute and Centre for Biomedical Genetics, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
J Biol Chem 276:8544-9. 2001..Our previous studies have implicated the c-Src tyrosine kinase in mediating transient closure of Cx43-based gap junctions in normal fibroblasts... - Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinomaPriya Koppikar
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Clin Cancer Res 14:4284-91. 2008..b>Src family kinases, including c-Src, mediate a variety of intracellular or extracellular signals that contribute to .. - Regulation of Akt/PKB activation by tyrosine phosphorylationR Chen
Department of Laboratory Medicine and Pathology and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Biol Chem 276:31858-62. 2001..tyrosine phosphorylation of Akt in COS1 and PC3M cells, which is abrogated by PP2, a selective inhibitor for Src family tyrosine kinases... - Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasionHiroshi Nozawa
Department of Oral and Maxillofacial Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
Clin Cancer Res 14:4336-44. 2008..The purpose of this study was to investigate the efficacy of combined inhibition of c-Src and PLCgamma-1 in the abrogation of HNSCC invasion. - STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor ReceptorMichael T Kloth
Departments of Internal Medicine and Microbiology and the Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908
J Biol Chem 278:1671-9. 2003Overexpression of the epidermal growth factor receptor (EGFR) and its association with the tyrosine kinase, c-Src, is correlated with increased cellular proliferation and tumorigenesis... - Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane regionA H Zisch
The Burnham Institute, La Jolla, California 92037, USA
Oncogene 16:2657-70. 1998..sites of the Eph receptors EphA3, EphA4, and EphB2 in embryonic retina serve as binding sites for the Src-homology 2 (SH2) domain of Src kinase... - Tyrosine phosphorylation of connexin 43 by v-Src is mediated by SH2 and SH3 domain interactionsM Y Kanemitsu
Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Biol Chem 272:22824-31. 1997Reduction of gap junctional communication in v-src transformed cells is accompanied by tyrosine phosphorylation of the gap junction protein, connexin 43 (Cx43). Cx43 is phosphorylated on tyrosine by v-Src... - Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinasesD D Schlaepfer
Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Mol Cell Biol 16:5623-33. 1996..We showed previously that the c-Src nonreceptor PTK and the Grb2 SH2/SH3 adaptor protein bound directly to FAK after fibronectin stimulation (D. D... - Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-SrcD D Schlaepfer
Salk Institute for Biological Studies, Molecular Biology and Virology Laboratory, La Jolla, California 92037, USA
J Biol Chem 272:13189-95. 1997..with integrin receptors, and FN-stimulated phosphorylation of FAK at Tyr-397 and Tyr-925 promotes the binding of Src family PTKs and Grb2, respectively... - c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor functionJ S Biscardi
Department of Microbiology and Cancer Center, Box 441, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
J Biol Chem 274:8335-43. 1999..that interactions between the epidermal growth factor receptor (EGFR) and the nonreceptor tyrosine kinase c-Src may contribute to an aggressive phenotype in multiple human tumors... - Regulation of platelet plasma membrane Ca2+-ATPase by cAMP-dependent and tyrosine phosphorylationW L Dean
Department of Biochemistry, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
J Biol Chem 272:15113-9. 1997..Phosphorylation of platelet plasma membranes by pp60(src) resulted in 75% inhibition of PMCA activity within 15 min... - c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cellsN Rahimi
Department of Pathology, Cancer Research Laboratories, Queen s University, Kingston, Ontario K7L 3N6, Canada
J Biol Chem 273:33714-21. 1998..The tyrosine kinase c-Src has been implicated as a modulator of cell proliferation, spreading, and migration; these functions are also .. - Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathwayYi Shen
Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892 4555, USA
J Biol Chem 283:5127-37. 2008..This in turn up-regulates epidermal growth factor receptor (EGFR) signaling to mediate Src activation, leading to E-cadherin ubiquitination and lysosomal degradation... - Dual targeting of Src and ER prevents acquired antihormone resistance in breast cancer cellsS Hiscox
Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff, Wales, UK
Breast Cancer Res Treat 115:57-67. 2009..we have shown that acquisition of resistance to tamoxifen in breast cancer cells is accompanied by an elevation in Src kinase activity which promotes an aggressive, invasive phenotype in vitro... - Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cellsGary S Goldberg
Department of Physiology and Biophysics, School of Medicine, Basic Science Tower T6, Health Science Complex, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
J Biol Chem 278:46533-40. 2003Cas is a member of the focal adhesion complex. Phosphorylation of Cas by Src is an important event leading to cell transformation. Using mass spectrometry, we have mapped 11 sites in Cas that are phosphorylated by Src... - E-cadherin adhesion activates c-Src signaling at cell-cell contactsRobert W McLachlan
Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia 4072
Mol Biol Cell 18:3214-23. 2007..In this report we tested the hypothesis that cadherin adhesion activates c-Src signaling and sought to assess its impact on cadherin function... - Inhibition of Src by direct interaction with protein phosphatase 2AN Yokoyama
Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
FEBS Lett 505:460-4. 2001In this study, we report that Src kinase is inhibited by protein phosphatase 2A (PP2A), a serine/threonine phosphatase. We carried out experiments in vitro using purified PP2A (AC dimer) and full-length v-Src or truncated forms of v-Src... - Heregulin and HER2 signaling selectively activates c-Src phosphorylation at tyrosine 215Ratna K Vadlamudi
Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
FEBS Lett 543:76-80. 2003..influence the migratory potential of breast cancer cells, we have used phospho-specific antibodies against c-Src kinase and focal adhesion kinase (FAK)... - Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinaseD D Schlaepfer
Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186
Nature 372:786-91. 1994..NIH3T3 fibroblasts to fibronectin promotes SH2-domain-mediated association of the GRB2 adaptor protein and the c-Src protein-tyrosine kinase (PTK) with FAK in vivo, and also results in activation of mitogen-activated protein kinase (.. - Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytesA Marie-Cardine
Ruprecht Karls University Heidelberg, Institute of Immunology, 69120 Heidelberg, Germany
J Biol Chem 272:16077-80. 1997In human T-lymphocytes the Src family protein tyrosine kinase p59(fyn) associates with three phosphoproteins of 43, 55, and 85 kDa (pp43, pp55, and pp85)... - Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activationB A Binstadt
Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
Immunity 5:629-38. 1996..Using a somatic genetic model, we first define a requirement for the Src family protein tyrosine kinase (PTK) Lck in mediating KIR tyrosine phosphorylation... - Detection of a physical and functional interaction between Csk and Lck which involves the SH2 domain of Csk and is mediated by autophosphorylation of Lck on tyrosine 394C Bougeret
INSERM, , France
J Biol Chem 271:7465-72. 1996The COOH-terminal Src kinase (Csk) is responsible for the phosphorylation of the conserved, negative regulatory, carboxyl-terminal tyrosine of most of the Src family protein tyrosine kinases... - Protein kinase activity is central to rat germ cell apoptosis induced by methoxyacetic acidT Jindo
Reproductive Toxicology Group, National Toxicology Program, NIEHS, Research Triangle Park, North Carolina, USA
Toxicol Pathol 29:607-16. 2001..immunocytochemistry with antibodies to various kinases (PKCmu, zeta, and gamma, AKAP220, CaMKII, MLCK, and Src) showed increased staining around dying spermatocytes following EGME treatment in vivo... - [Developmental disorders and their responsible genes; the genes involved in neuronal positioning]K Mikoshiba
Institute of Medical Science, University of Tokyo
No To Hattatsu 32:208-19. 2000..The information of CR-50 antigen/Reelin is considered to be transmitted inside the neuroblasts to the "disabled 1", which is an adaptor protein to Src, Fyn, Abl tyrosine kinase. - Truncated estrogen receptor product-1 suppresses estrogen receptor transactivation by dimerization with estrogen receptors alpha and betaE M Resnick
Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22903, USA
J Biol Chem 275:7158-66. 2000..that it modulates ER function by direct interactions with full-length ER or the steroid receptor coactivator, SRC-1... - Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivatorsW Yang
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Mol Cell Biol 20:8008-17. 2000..PPARgamma is known to interact with both the p160/SRC-1 family of coactivators and the distinct, multisubunit coactivator complex called DRIP... - Mutation of csk, encoding the C-terminal Src kinase, reduces Pseudomonas aeruginosa internalization by mammalian cells and enhances bacterial cytotoxicityDavid J Evans
Morton D Sarver Laboratory for Cornea and Contact Lens Research, School of Optometry, University of California at Berkeley, Berkeley, California 94720, USA
Microb Pathog 33:135-43. 2002..Another ExsA regulated protein, ExoU, is involved in the cytotoxic activity of cytotoxic strains. Src-family kinases are thought to participate in the regulation of cytoskeleton function... - Cellular and molecular aspects of neurocarcinogenesisP Kleihues
Department of Pathology, , Switzerland
Toxicol Pathol 18:193-203. 1990..Introduction of the viral src gene caused astrocytic and mesenchymal tumors after latency periods of 2-6 months... - p300 mediates functional synergism between AF-1 and AF-2 of estrogen receptor alpha and beta by interacting directly with the N-terminal A/B domainsY Kobayashi
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan
J Biol Chem 275:15645-51. 2000..AF-2 coactivators, p300/CREB binding protein, steroid receptor coactivator-1/transcriptional intermediary factor-2 (SRC-1/TIF2) family proteins and thyroid hormone receptor-associated protein-220/(vitamin D3 receptor-interacting .. - Temporal formation of distinct thyroid hormone receptor coactivator complexes in HeLa cellsD Sharma
Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
Mol Endocrinol 14:2001-9. 2000..implicated in ligand-dependent activation by TR include p300, the CREB-binding protein (CBP), members of the p160/SRC family, and the multisubunit TR-associated protein (TRAP) complex... - The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase works as an arsenate reductase in human red blood cells and rat liver cytosolZoltan Gregus
Department of Pharmacology and Pharmacotherapy, Toxicology Section, University of Pecs, Medical School, Pecs, Hungary
Toxicol Sci 85:859-69. 2005The mammalian enzymes responsible for reduction of the environmentally prevalent arsenate (AsV) to the much more toxic arsenite (AsIII) are unknown... - Effect of flow-triggered adaptive servo-ventilation compared with continuous positive airway pressure in patients with chronic heart failure with coexisting obstructive sleep apnea and Cheyne-Stokes respirationTakatoshi Kasai
Sleep Center, Toranomon Hospital, Tokyo, Japan
Circ Heart Fail 3:140-8. 2010..Recently, it was reported that adaptive servo-ventilation (ASV) can effectively treat sleep-disordered breathing... - Cardiac hypertrophy in the Dahl rat is associated with increased tyrosine phosphorylation of several cytosolic proteins, including a 120 kDa proteinS W Rabkin
University of British Columbia, Department of Medicine, Vancouver, Canada
Am J Hypertens 9:230-6. 1996..was carried out with antibodies to the signal transducing proteins rasGAP, JAK2 iNOS, p125FAK, and the Src substrate, pp120, but all proved negative... - Purine nucleoside phosphorylase as a cytosolic arsenate reductaseZoltan Gregus
Department of Pharmacology and Pharmacotherapy, University of Pecs, Medical School, Szigeti ut 12, H 7624, Pecs, Hungary
Toxicol Sci 70:13-9. 2002The findings of the accompanying paper (Németi and Gregus, Toxicol: Sci. 70, 4-12) indicate that the arsenate (AsV) reductase activity of rat liver cytosol is due to an SH enzyme that uses phosphate (or its analogue, arsenate, AsV) and .. - Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at adipocytesG Muller
Hoechst AG Frankfurt, Germany
Horm Metab Res 28:469-87. 1996..phospholipase (PLC), the caveolae-specific coast protein, caveolin, and acylated tyrosine kinases of the src family. Sulfonylureas were found to stimulate the GPI-PLC and tyrosine phosphorylation of caveolin... - The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: a toxicochemical reviewDean E Carter
Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721 0207, USA
Toxicol Appl Pharmacol 193:309-34. 2003..It is unclear if the differences in parameters such as the presence or absence of methyl metabolites, the rates of AsV reduction compared to the rates of AsIII oxidation, or the competition of phosphate and arsenate for cellular .. - Efficacy of adaptive servoventilation in patients with congestive heart failure and Cheyne-Stokes respirationXi long Zhang
Department of Respiratory Diseases, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
Chin Med J (Engl) 119:622-7. 2006..Adaptive servoventilation (ASV) is a novel method of ventilatory support designed for removal of CSF in CHF patients... - Adaptive support ventilation for gynaecological laparoscopic surgery in Trendelenburg position: bringing ICU modes of mechanical ventilation to the operating roomJulio Llorens
Hospital Clinico Universitario de Valencia, Anaesthesiology and Critical Care, Valencia, Spain
Eur J Anaesthesiol 26:135-9. 2009The aim of the present study was to test the efficacy of adaptive support ventilation (ASV) to automatically adapt the ventilatory settings to the changes in the respiratory mechanics that occur during pneumoperitoneum and Trendelenburg .. - Relationship between ventricular morphology and aqueductal cerebrospinal fluid flow in healthy and communicating hydrocephalusWilliam W Chiang
Departments of Radiology, University of Illinois, Chicago, Illinois 60612, USA
Invest Radiol 44:192-9. 2009..This work aims to determine the role of anatomic and hydrodynamic factors in modulating the magnitude of CSF flow through the aqueduct... - Mechanism of thiol-supported arsenate reduction mediated by phosphorolytic-arsenolytic enzymes: I. The role of arsenolysisBalazs Nemeti
Department of Pharmacology and Pharmacotherapy, Toxicology Section, University of Pecs, Medical School, Pecs 7624, Hungary
Toxicol Sci 110:270-81. 2009..of their substrates (thus yielding arsenylated metabolites) have been shown to facilitate reduction of arsenate (AsV) to the more toxic arsenite (AsIII) in presence of their substrate and a thiol... - Adaptive servoventilation versus noninvasive positive pressure ventilation for central, mixed, and complex sleep apnea syndromesTimothy I Morgenthaler
Mayo Clinic Sleep Disorders Center, 200 First Street SW, Rochester, MN 55905, USA
Sleep 30:468-75. 2007.... - Glutathione-supported arsenate reduction coupled to arsenolysis catalyzed by ornithine carbamoyl transferaseBalazs Nemeti
Department of Pharmacology and Pharmacotherapy, Toxicology Section, University of Pecs, Medical School, Szigeti ut 12, H 7624 Pecs, Hungary
Toxicol Appl Pharmacol 239:154-61. 2009..glycogen phosphorylase, glyceraldehyde-3-phosphate dehydrogenase) have been shown to mediate reduction of arsenate (AsV) to the more toxic arsenite (AsIII) in a thiol-dependent manner... - Mechanism of thiol-supported arsenate reduction mediated by phosphorolytic-arsenolytic enzymes: II. Enzymatic formation of arsenylated products susceptible for reduction to arsenite by thiolsZoltan Gregus
Department of Pharmacology and Pharmacotherapy, Toxicology Section, University of Pecs, Medical School, Pecs 7624, Hungary
Toxicol Sci 110:282-92. 2009Enzymes catalyzing the phosphorolytic cleavage of their substrates can reduce arsenate (AsV) to the more toxic arsenite (AsIII) via the arsenolytic substrate cleavage in presence of a reductant, as glutathione or dithiotreitol (DTT)... - Establishing of monitoring network on Kosovo Rivers: preliminary measurements on the four main rivers (Drini i Bardhë, Morava e Binqës, Lepenc and Sitnica)Fatbardh Gashi
Faculty of Natural Science, Department of Chemistry, University of Prishtina, 10000, Prishtina, Kosovo
Environ Monit Assess 175:279-89. 2011..Pb(II), Cd(II), Zn(II) and Mn(II) in waters of four main rivers of Kosovo, using Anodic Stripping Voltammetry (ASV), Atomic Absorption Spectrophotometry (AAS) and Ultraviolet-Visible (UV-VIS) Spectrometry... - Arsenic metabolism in multiple myeloma and astrocytoma cellsIngrid Falnoga
Department of Environmental Sciences, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
Biol Trace Elem Res 116:5-28. 2007..Pentavalent inorganic arsenic (AsV) was identified in both cell types, and up to 80% of total As in MM bone marrow cell lysates was present as AsV... - Effect of dissolved organic matter (DOM) of contrasting origins on Cu and Pb speciation and toxicity to Paracentrotus lividus larvaePaula Sánchez-Marín
Laboratorio de Ecoloxía Mariña, Universidade de Vigo, Campus Universitario, Vigo, Galicia, Spain
Aquat Toxicol 96:90-102. 2010..Cu and Pb complexation properties were measured by anodic stripping voltammetry (ASV) and the effect of DOM on Cu and Pb bioavailability was studied by means of the Paracentrotus lividus embryo-larval .. - BRCA1-IRIS regulates cyclin D1 expression in breast cancer cellsEnkeleda Nakuci
Dana Farber Cancer Institute and Harvard Medical School, 44 Binney St, Boston, MA 02115, USA
Exp Cell Res 312:3120-31. 2006..In this study, we show that: (1) BRCA1-IRIS forms complex with two of the nuclear receptor co-activators, namely, SRC1 and SRC3 (AIB1) in an ERalpha-independent manner... - Chronic treatment with zinc and antidepressants induces enhancement of presynaptic/extracellular zinc concentration in the rat prefrontal cortexMagdalena Sowa-Kućma
Institute of Pharmacology, Polish Academy of Sciences and Center of Excellence in Neuropsychopharmacology, Smetna 12, 31 343, Krakow, Poland
Amino Acids 40:249-58. 2011..zinc-selenium histochemistry (which images the pool of presynaptic-vesicle zinc) and anodic stripping voltammetry (ASV) for zinc determination in microdialysate (which assays the extracellular zinc concentration)... - Correlation between the %MinVol setting and work of breathing during adaptive support ventilation in patients with respiratory failureChin Pyng Wu
Division of Chest Medicine, Department of Internal Medicine, Tri Service General Hospital, Taipei, Taiwan
Respir Care 55:334-41. 2010Adaptive support ventilation (ASV) is a new mode of mechanical ventilation that seeks an optimal breathing pattern based on the minimum work of breathing (WOB) principle... - Adaptive servoventilation (ASV) in patients with sleep disordered breathing associated with chronic opioid medications for non-malignant painRobert J Farney
Intermountain Sleep Disorders Center, LDS Hospital, 325 8th Ave and C Street, Salt Lake City, UT 84143, USA
J Clin Sleep Med 4:311-9. 2008Adaptive servoventilation (ASV) can be effective therapy for specific types of central apnea such as Cheyne-Stokes respiration (CSR)... - Unruptured aneurysm of sinus of Valsalva with right ventricular outflow tract obstructionC F Huang
Department of Pediatrics, Chang Gung Children's Hospital, Kaohsiung, Taiwan, ROC
Chang Gung Med J 24:746-50. 2001Aneurysm of the sinus of Valsalva (ASV) is a rare anomaly. It may be congenital or acquired basis. In pediatric patients, most are congenital in origin... - Factors controlling stripping voltammetry of lead at polycrystalline boron doped diamond electrodes: new insights from high-resolution microscopyLaura A Hutton
Departments of Chemistry and Physics, University of Warwick, Coventry CV4 7AL, United Kingdom
Anal Chem 83:735-45. 2011..have revealed new insights into the features observed in differential pulse anodic stripping voltammetry (DPV-ASV) which provide a deeper understanding of how best to utilize this technique...
Research Grants
- Metabolism and Toxicity of Arsenic in the Human LiverMiroslav Styblo; Fiscal Year: 2010..that express AS3MT methylate iAs to methyl-As (MAs) and dimethyl-As (DMAs) species that contain either AsIII or AsV. These metabolites are also found in urine of individuals exposed to iAs from environmental sources and patients ..
- REGULATION OF GP 11B 111A BY THE PLATELET CYTOSKELETONJoan Fox; Fiscal Year: 1999..1) GPIIb-IIIa is associated with the membrane skeleton in unstimulated platelets, 2) the tyrosine kinase, pp60c-src, appears to be associated with the membrane skeleton of platelets that are not yet competent to bind fibrinogen, ..
- Programmed Adipogenesis and Lipid DysregulationMina Desai; Fiscal Year: 2010..adipose tissue PPAR?2 gene expression with downregulation of co-repressor NCoR, and upregulation of co-activator SRC1. Thus, the changes in co-regulators may well be the fundamental underlying factor(s) contributing to programmed ..
- Assays for Estrogen and Progesterone Receptor AntagonistsDavid Shapiro; Fiscal Year: 2007..analyze the interaction of liganded ER and PR with their DNA response elements and with a full-length co-activator (SRC1) and demonstrated FAMA's potential for high throughput screening (HTS) assays...
- INTEGRATION OF RETROVIRAL DNA--ACCESSING HOST TARGET DNAAnna Marie Skalka; Fiscal Year: 2005..The avian sarcoma/leukosis virus (ASV) is the primary model for these studies...
- A Novel Sensor for total Mercury in Fish TissueSHANTHA SARANGAPANI; Fiscal Year: 2002..electrodes with dendrimer-gold nano composite for the "in situ" anodic stripping voltammetric analysis (ASV) of total mercury in fish tissue samples. Alternate methods of sample preparations will be tested...
- INTL CONG OF VIROLOGY, SAN FRANCISCO, ASV TRAVEL REQUESTPATRICIA SPEAR; Fiscal Year: 2005..The ASV considers one excellent way to stimulate and aid junior researchers in their future work is to enable them to ..
- INTL CONG OF VIROLOGY, PARISDENNIS O CALLAGHAN; Fiscal Year: 2002The American Society for Virology (ASV) requests funds to provide partial support for the travel of selected outstanding junior virologists to participate in the 12th International Congress of Virology (ICV) to be held 27 July - 1 Aug ..
- CRF-Type-2 Receptor Antagonists for AnxietyKathleen Gogas; Fiscal Year: 2002..and urocortin II verified the importance of the CRF2 receptor in anorectic behavior, but the antisauvagine-30 (ASV-30) data also suggested that the CRF2 receptor may be involved in emotional behavior and anxiety...
- ASV INTEGRASE--MECHANISM OF DNA BINDING AND RECOGNITIONIsaac Wong; Fiscal Year: 2002..titration techniques to elucidate the mechanism of cognate-site (CATT) recognition by the Avian Sarcoma Virus (ASV) integrase (IN) and to define the structure- function relationship between recognition and regulation of catalytic ..
- ASV INTEGRASE--MECHANISM OF DNA BINDING AND RECOGNITIONIsaac Wong; Fiscal Year: 2002..titration techniques to elucidate the mechanism of cognate-site (CATT) recognition by the Avian Sarcoma Virus (ASV) integrase (IN) and to define the structure- function relationship between recognition and regulation of catalytic ..
- Crosslinking stabilization of integrase-DNA complexesELENA PELETSKAYA; Fiscal Year: 2006..We propose to obtain stabilized IN-DNA complexes suitable for structural and biochemical studies of HIV-1 and ASV integrase by chemically crosslinking the protein to nucleic acid, without distorting their structures...
- STRUCTURE/FUNCTION OF INTEGRASEANNA SKALKA; Fiscal Year: 2001..They also build upon the extensive experience of the PI and collaborators with both the human (HIV) and avian (ASV) viral integration systems, and the ability to utilize ASV IN as a valuable base of comparison...
- Natural Mutation at the Coactivator Binding Site of ERMark Nichols; Fiscal Year: 2002..experiments; 3) to isolate via RT-PCR and assay transcription with ER interacting! p160 coactivator clones SRC1, GRIP1, and NCOR cDNAs recovered from tissue samples, and 4) to isolate and identify further naturally occurring ER ..