Gene Symbol: SPTBN1
Description: spectrin beta, non-erythrocytic 1
Alias: ELF, HEL102, SPTB2, betaSpII, spectrin beta chain, non-erythrocytic 1, beta-G spectrin, beta-II spectrin, beta-fodrin, beta-spectrin 2, beta-spectrin II, beta-spectrin non-erythrocytic 1, embryonic liver beta-fodrin, epididymis luminal protein 102, fodrin beta chain, spectrin beta chain, brain 1, spectrin, non-erythroid beta chain 1
Species: human
Products:     SPTBN1

Top Publications

  1. Tang Y, Katuri V, Dillner A, Mishra B, Deng C, Mishra L. Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science. 2003;299:574-7 pubmed
    Disruption of the adaptor protein ELF, a beta-spectrin, leads to disruption of transforming growth factor-beta (TGF-beta) signaling by Smad proteins in mice...
  2. Baek H, Lim S, Kitisin K, Jogunoori W, Tang Y, Marshall M, et al. Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis. Hepatology. 2008;48:1128-37 pubmed publisher
    We have previously demonstrated that 40%-70% of elf(+/-) mice spontaneously develop hepatocellular cancer (HCC) within 15 months, revealing the importance of the transforming growth factor-beta (TGF-beta) signaling pathway in suppressing ..
  3. Chang J, Scarpa A, Eddy R, Byers M, Harris A, Morrow J, et al. Cloning of a portion of the chromosomal gene and cDNA for human beta-fodrin, the nonerythroid form of beta-spectrin. Genomics. 1993;17:287-93 pubmed
    ..beta-Fodrin was assigned the gene symbol SPTBN1.
  4. Kitisin K, Ganesan N, Tang Y, Jogunoori W, Volpe E, Kim S, et al. Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation. Oncogene. 2007;26:7103-10 pubmed
    ..signaling members, TGF-beta receptor type II (TBRII), Smad2, Smad4 and Smad adaptor, embryonic liver fodrin (ELF), are prominent tumor suppressors in gastrointestinal cancers...
  5. Susuki K, Zollinger D, Chang K, Zhang C, Huang C, Tsai C, et al. Glial βII Spectrin Contributes to Paranode Formation and Maintenance. J Neurosci. 2018;38:6063-6075 pubmed publisher
    ..generated mutant mice lacking βII spectrin in myelinating glial cells by crossing mice with a floxed allele of Sptbn1 with Cnp-Cre mice, and analyzed both male and female mice...
  6. Niimori Kita K, Ogino K, Mikami S, Kudoh S, Koizumi D, Kudoh N, et al. Identification of nuclear phosphoproteins as novel tobacco markers in mouse lung tissue following short-term exposure to tobacco smoke. FEBS Open Bio. 2014;4:746-54 pubmed publisher
    ..acid-binding protein, in the 7-day exposure group, and peroxiredoxin-1 (OSF3) and spectrin β chain brain 1 (SPTBN1), in both groups...
  7. Chen J, Shukla V, Farci P, Andricovich J, Jogunoori W, Kwong L, et al. Loss of the transforming growth factor-? effector ?2-Spectrin promotes genomic instability. Hepatology. 2017;65:678-693 pubmed publisher
    ..for the transforming growth factor ?/mothers against decapentaplegic homolog 3 adaptor ?2-Spectrin (?2SP, gene Sptbn1) in maintaining genomic stability following alcohol-induced DNA damage...
  8. Ying J, Lin C, Wu J, Guo L, Qiu T, Ling Y, et al. Anaplastic Lymphoma Kinase Rearrangement in Digestive Tract Cancer: Implication for Targeted Therapy in Chinese Population. PLoS ONE. 2015;10:e0144731 pubmed publisher
    ..target gene enrichment and sequencing revealed ALK was fused to a novel partner, spectrin beta non-erythrocytic 1 (SPTBN1)...
  9. Zhu Z, Yang Q, Li C, Chen J, Xiang M, Chen M, et al. Identification of biomarkers for childhood obesity based on expressional correlation and functional similarity. Mol Med Rep. 2017;: pubmed publisher
    ..protein tau (MAPT), destrin (actin depolymerizing factor) (DSTN) and spectrin, ?, non?erythrocytic 1 (SPTBN1); downregulated genes, Rho/Rac guanine nucleotide exchange factor 2 (ARHGEF2) and spindle and kinetochore ..

More Information

Publications136 found, 100 shown here

  1. Javed Z, Papageorgiou M, Deshmukh H, Kilpatrick E, Mann V, Corless L, et al. A Randomized, Controlled Trial of Vitamin D Supplementation on Cardiovascular Risk Factors, Hormones, and Liver Markers in Women with Polycystic Ovary Syndrome. Nutrients. 2019;11: pubmed publisher
    ..type III procollagen (PIIINP), tissue inhibitor of metallo-proteinases-1 (TIMP-1), and the enhanced liver fibrosis (ELF) score). Forty women with PCOS were recruited and randomized to vitamin D (3200 IU) or placebo daily for 3 months...
  2. Chen J, Yao Z, Chen J, Gi Y, Muñoz N, Kundra S, et al. TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome. J Clin Invest. 2016;126:527-42 pubmed publisher
    ..Epigenetic silencing of β2-spectrin (β2SP, encoded by SPTBN1), a SMAD adaptor for TGF-β signaling, is causally associated with BWS; however, a role of TGF-β deficiency ..
  3. Baek H, Lee Y, Kim T, Kim J, Park E, Iwabuchi K, et al. Caspase-3/7-mediated Cleavage of β2-spectrin is Required for Acetaminophen-induced Liver Damage. Int J Biol Sci. 2016;12:172-83 pubmed publisher
    The ubiquitously expressed β2-spectrin (β2SP, SPTBN1) is the most common non-erythrocytic member of the β-spectrin gene family...
  4. Tanaka H, Fukahori S, Baba S, Ueno T, Sivakumar R, Yagi M, et al. Branched-Chain Amino Acid-Rich Supplements Containing Microelements Have Antioxidant Effects on Nonalcoholic Steatohepatitis in Mice. JPEN J Parenter Enteral Nutr. 2016;40:519-28 pubmed publisher
    ..The expression levels of insulin receptor β subunit (IRβ) and p-elF in groups E and F and those of phosphatidyl-inositol 3 kinase (PI3K85), p-AcelCoA, and PERK in group F were similar ..
  5. Niculescu A, Le Niculescu H, Levey D, Phalen P, Dainton H, ROSEBERRY K, et al. Precision medicine for suicidality: from universality to subtypes and personalization. Mol Psychiatry. 2017;22:1250-1273 pubmed publisher
    ..We identified completely novel biomarkers (such as SPTBN1 and C7orf73), and reinforced previously known biomarkers (such as PTEN and SAT1)...
  6. Gordon E, Yao X, Xu H, Karkowsky W, Kaler M, Kalchiem Dekel O, et al. Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects. J Allergy Clin Immunol. 2019;: pubmed publisher
  7. Luo X, Jia S, Li R, Gao P, Zhang Y. Occupational exposure to 50 Hz magnetic fields does not alter responses of inflammatory genes and activation of splenic lymphocytes in mice. Int J Occup Med Environ Health. 2016;29:277-91 pubmed publisher
    ..conditions, body weight of the mice exposed to occupational, extremely low frequency- electromagnetic fields (ELF-EMFs) significantly decreased on day 20 and day 30...
  8. Palaniyappan N, Cox E, Bradley C, Scott R, Austin A, O Neill R, et al. Non-invasive assessment of portal hypertension using quantitative magnetic resonance imaging. J Hepatol. 2016;65:1131-1139 pubmed publisher
    ..We estimated the liver stiffness measurement (LSM) and enhanced liver fibrosis (ELF) score. The correlation of all non-invasive parameters with HVPG was evaluated...
  9. Lin Y, Zhou Q, Onufrak N, Wirth V, Chen K, Wang J, et al. Aerosolized Polymyxin B for Treatment of Respiratory Tract Infections: Determination of Pharmacokinetic-Pharmacodynamic Indices for Aerosolized Polymyxin B against Pseudomonas aeruginosa in a Mouse Lung Infection Model. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..A two-compartment PK model was required for both epithelial lining fluid (ELF) and plasma drug exposure...
  10. Facco M, Nespeca M, Simonato M, Isak I, Verlato G, Ciambra G, et al. In vivo effect of pneumonia on surfactant disaturated-phosphatidylcholine kinetics in newborn infants. PLoS ONE. 2014;9:e93612 pubmed publisher
    ..MPO) activity, as a marker of lung inflammation, was 1322 (531-2821) mU/ml of Epithelial Lining Fluid (ELF) and 371(174-1080) mU/ml ELF in infants with pneumonia and in controls, p = 0.047...
  11. Hamed A, El Kharashi O, Boctor S, Abd Elaziz L. Potential involvement of PPAR ? activation in diminishing the hepatoprotective effect of fenofibrate in NAFLD: Accuracy of non- invasive panel in determining the stage of liver fibrosis in rats. Biomed Pharmacother. 2017;85:68-78 pubmed publisher
    ..Moreover, this work implies the enhanced liver fibrosis (ELF) panel diagnostic performance in diagnosis of any and moderate degree of fibrosis in rats with NAFLD.
  12. Vesterhus M, Holm A, Hov J, Nygard S, Schrumpf E, Melum E, et al. Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. J Hepatol. 2017;66:1214-1222 pubmed publisher
    ..However, the Enhanced Liver Fibrosis (ELF®) test and Mayo risk score proved to be stronger predictors of transplant-free survival...
  13. Dey S, Bose S, Kumar S, Rathore R, Mathur R, Jain S. Extremely low frequency magnetic field protects injured spinal cord from the microglia- and iron-induced tissue damage. Electromagn Biol Med. 2017;36:330-340 pubmed publisher
    ..These novel findings suggest that exposure to ELF-MF reduces lesion volume, inflammation and iron content in addition to facilitation of angiogenesis following SCI.
  14. Fathi E, Farahzadi R. Zinc Sulphate Mediates the Stimulation of Cell Proliferation of Rat Adipose Tissue-Derived Mesenchymal Stem Cells Under High Intensity of EMF Exposure. Biol Trace Elem Res. 2018;184:529-535 pubmed publisher
    ..ZnSO4) could affect cell proliferation of rADSCs under extremely low frequency-electromagnetic field (ELF-EMF)...
  15. Swaminathan S, Hu X, Zheng X, Kriga Y, Shetty J, Zhao Y, et al. Interleukin-27 treated human macrophages induce the expression of novel microRNAs which may mediate anti-viral properties. Biochem Biophys Res Commun. 2013;434:228-34 pubmed publisher
    ..This induction occurred in an interferon (IFN) independent manner and involved down regulation of SPTBN1. MicroRNAs (miRNAs) are critical regulators of mRNA translation and turnover...
  16. Berkhout J, Melchers M, van Mil A, Seyedmousavi S, Lagarde C, Nichols W, et al. Pharmacokinetics and penetration of ceftazidime and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrob Agents Chemother. 2015;59:2299-304 pubmed publisher
    ..thigh infection model and lung infection model to study pharmacokinetics in plasma and epithelial lining fluid (ELF). Mice were infected with ca...
  17. Zaki S. Evaluation of antioxidant and anti-lipid peroxidation potentials of Nigella sativa and onion extract on nicotine-induced lung damage. Folia Morphol (Warsz). 2018;: pubmed publisher
    ..MDA), superoxide dismutase activity (SOD), catalase (CAT), lung GSH, and epithelial lining fluid GSH (ELF GSH) were used for assessment of the antioxidant and anti-lipid peroxidation potentials of NS and onion extract...
  18. Ke L, Zheng X, Sun Y, Ouyang W, Zhang Z. Effects of Sodium Fluoride on Lipid Peroxidation and PARP, XBP-1 Expression in PC12 Cell. Biol Trace Elem Res. 2016;173:161-7 pubmed publisher
    ..Western blot analysis was performed to detect apoptosis-related poly (ADP-ribose) polymerase (PARP) protein, p-elF, and expression of the endoplasmic reticulum stress-related X-box binding protein 1 (XBP-1)...
  19. Guan F, Bailey C, Metierre C, O Young P, Gao D, Khoo T, et al. The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivo. J Hematol Oncol. 2017;10:75 pubmed publisher
    ..We compared the function of ELF2 isoforms ELF2A and ELF2B with other ELF subfamily proteins ELF1 and ELF4 in primary and cancer cell lines using proliferation, colony-forming, cell cycle, ..
  20. Velsor L, van Heeckeren A, Day B. Antioxidant imbalance in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice. Am J Physiol Lung Cell Mol Physiol. 2001;281:L31-8 pubmed
    ..To test whether the CFTR protein modulates lung antioxidant defenses in vivo, epithelial lining fluid (ELF) and lung tissue from CFTR knockout (CFTR-KO) and wild-type (WT) mice were compared for GSH content and the ..
  21. de Kleijn S, Ferwerda G, Wiese M, Trentelman J, Cuppen J, Kozicz T, et al. A short-term extremely low frequency electromagnetic field exposure increases circulating leukocyte numbers and affects HPA-axis signaling in mice. Bioelectromagnetics. 2016;37:433-43 pubmed publisher
    There is still uncertainty whether extremely low frequency electromagnetic fields (ELF-EMF) can induce health effects like immunomodulation...
  22. Gould N, Min E, Huang J, Chu H, Good J, Martin R, et al. Glutathione Depletion Accelerates Cigarette Smoke-Induced Inflammation and Airspace Enlargement. Toxicol Sci. 2015;147:466-74 pubmed publisher
    ..Older cigarette smokers show a decline (67%) in lung epithelial lining fluid (ELF) GSH and a 1...
  23. Yin C, Luo X, Duan Y, Duan W, Zhang H, He Y, et al. Neuroprotective effects of lotus seedpod procyanidins on extremely low frequency electromagnetic field-induced neurotoxicity in primary cultured hippocampal neurons. Biomed Pharmacother. 2016;82:628-39 pubmed publisher
    ..the protective effects of lotus seedpod procyanidins (LSPCs) on extremely low frequency electromagnetic field (ELF-EMF)-induced neurotoxicity in primary cultured rat hippocampal neurons and the underlying molecular mechanism...
  24. Ando M, Kawazu M, Ueno T, Koinuma D, Ando K, Koya J, et al. Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer. Cancer Res. 2016;76:1814-24 pubmed publisher
    ..Collectively, our findings reveal a novel subtype of human cancer characterized by inactivating mutations in the ELF subfamily of proteins, and warrant further investigation of the specific settings where ELF restoration may be ..
  25. Wang S, Feng L, Meng Z. Bicluster and pathway enrichment analysis related to tumor progression of hepatocellular carcinoma. Eur Rev Med Pharmacol Sci. 2015;19:1191-7 pubmed
    ..expressed genes might play crucial roles in the progression of hepatocellular carcinoma, such as GADD45G, SPTBN1, CDC27, TPD52 and INSIG1...
  26. Vilar Gomez E, Chalasani N. Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers. J Hepatol. 2018;68:305-315 pubmed publisher
    ..g. circulating keratin 18 fragments), or fibrosis (e.g. FibroTest®, ELF™ or Pro-C3 tests)...
  27. Yang Y, Wang X, Liu Y, Fu Q, Tian C, Wu C, et al. Transcriptome analysis reveals enrichment of genes associated with auditory system in swimbladder of channel catfish. Comp Biochem Physiol Part D Genomics Proteomics. 2018;27:30-39 pubmed publisher
    ..stimulus, or detection of mechanical stimulus involved in sensory perception of sound, such as coch, kcnq4, sptbn1, sptbn4, dnm1, ush2a, and col11a1...
  28. Chen H, Zuo Q, Wang Y, Song J, Yang H, Zhang Y, et al. Inducing goat pluripotent stem cells with four transcription factor mRNAs that activate endogenous promoters. BMC Biotechnol. 2017;17:11 pubmed publisher
    ..Transcription factor binding sites, including Elf-1, AP-2, SP1, C/EBP and MZF1, were identified to be functional in the core promoter regions of these reprogramming ..
  29. Hayakawa M. Possible Electromagnetic Effects on Abnormal Animal Behavior Before an Earthquake. Animals (Basel). 2013;3:19-32 pubmed publisher
    ..in terms of three plots, it is likely that lower frequency (ULF (ultra-low-frequency, f ≤ 1 Hz) and ELF (extremely-low-frequency, f ≤ a few hundreds Hz)) electromagnetic emissions exhibit a very similar temporal ..
  30. Patruno A, Pesce M, Grilli A, Speranza L, Franceschelli S, De Lutiis M, et al. mTOR Activation by PI3K/Akt and ERK Signaling in Short ELF-EMF Exposed Human Keratinocytes. PLoS ONE. 2015;10:e0139644 pubmed publisher
    Several reports suggest that ELF-EMF exposures interact with biological processes including promotion of cell proliferation. However, the molecular mechanisms by which ELF-EMF controls cell growth are not completely understood...
  31. Shahbazi Gahrouei D, Shiri L, Alaei H, Naghdi N. The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat. J Radiat Res. 2016;57:127-32 pubmed publisher
    The aim of this study was to investigate the effect of continuous extremely low frequency magnetic fields (ELF-MFs) with a frequency of 10 Hz and an intensity of 690-720 μT on the level of 5-hydroxyindolacetic acid (5-HIAA) in adult ..
  32. Haner J, Matsumoto K, Mercier H, Schrobilgen G. Nature of the Xe(VI)-N Bonds in F6 XeNCCH3 and F6 Xe(NCCH3)2 and the Stereochemical Activity of Their Xenon Valence Electron Lone Pairs. Chemistry. 2016;22:4833-42 pubmed publisher
    ..Herein, the natural bond orbital (NBO), atoms in molecules (AIM), electron localization function (ELF), and molecular electrostatic potential surface (MEPS) analyses show that the Xe valence electron lone pairs (VELPs)..
  33. Kitaoka K, Kawata S, Yoshida T, Kadoriku F, Kitamura M. Exposure to an Extremely-Low-Frequency Magnetic Field Stimulates Adrenal Steroidogenesis via Inhibition of Phosphodiesterase Activity in a Mouse Adrenal Cell Line. PLoS ONE. 2016;11:e0154167 pubmed publisher
    Extremely low-frequency magnetic fields (ELF-MFs) are generated by power lines and household electrical devices...
  34. Carlberg M, Koppel T, Ahonen M, Hardell L. Case-control study on occupational exposure to extremely low-frequency electromagnetic fields and glioma risk. Am J Ind Med. 2017;60:494-503 pubmed publisher
    Exposure to extremely low-frequency electromagnetic fields (ELF-EMF) was in 2002 classified as a possible human carcinogen, Group 2B, by the International Agency for Research on Cancer at WHO.
  35. Djordjević N, Paunovic M, Peulic A. Anxiety-like behavioural effects of extremely low-frequency electromagnetic field in rats. Environ Sci Pollut Res Int. 2017;24:21693-21699 pubmed publisher
    In recent years, extremely low-frequency electromagnetic field (ELF-EMF) has received considerable attention for its potential biological effects. Numerous studies have shown the role of ELF-EMF in behaviour modulation...
  36. Migault L, Piel C, Carles C, Delva F, Lacourt A, Cardis E, et al. Maternal cumulative exposure to extremely low frequency electromagnetic fields and pregnancy outcomes in the Elfe cohort. Environ Int. 2018;112:165-173 pubmed publisher
    To study the relations between maternal cumulative exposure to extremely low frequency electromagnetic fields (ELF EMF) and the risk of moderate prematurity and small for gestational age within the Elfe cohort...
  37. Lee J, Jeon J, You T. Structure and Chemical Bonding of the Li-Doped Polar Intermetallic RE?In1-xLixGe? (RE = La, Nd, Sm, Gd; x = 0.13, 0.28, 0.43, 0.53) System. Materials (Basel). 2018;11: pubmed publisher
    ..crystal orbital Hamilton population (COHP) curves representing various interatomic interactions and an electron localization function (ELF) diagram indicating the locations of paired-electron densities are also provided in this article.
  38. Shimizu T, Takakuwa Y, Koizumi H, Ishibashi T, Ohkawara A. Calcium-dependent peripheral localization of 4.1-like proteins and fodrin in cultured human keratinocytes. Biol Cell. 1996;86:19-26 pubmed
  39. Hayes N, Scott C, Heerkens E, Ohanian V, Maggs A, Pinder J, et al. Identification of a novel C-terminal variant of beta II spectrin: two isoforms of beta II spectrin have distinct intracellular locations and activities. J Cell Sci. 2000;113 ( Pt 11):2023-34 pubmed
    ..We conclude that variation in the structure of the C-terminal regions of betaII spectrin isoforms correlates with their differential intracellular targeting. ..
  40. de Groot M, van Kleef R, de Groot A, Westerink R. In Vitro Developmental Neurotoxicity Following Chronic Exposure to 50 Hz Extremely Low-Frequency Electromagnetic Fields in Primary Rat Cortical Cultures. Toxicol Sci. 2016;149:433-40 pubmed publisher
    Exposure to 50-60 Hz extremely low-frequency electromagnetic fields (ELF-EMFs) has increased considerably over the last decades...
  41. Debackere J, Bortolus M, Schrobilgen G. Synthesis and Characterization of [XeOXe](2+) in the Adduct-Cation Salt, [CH3 CN-?-?-XeOXe-?-?-NCCH3 ][AsF6 ]2. Angew Chem Int Ed Engl. 2016;55:11917-20 pubmed publisher
    ..Natural bond orbital (NBO), atoms in molecules (AIM), electron localization function (ELF), and molecular electrostatic potential surface (MEPS) analyses show that the Xe-O bonds are semi-ionic whereas the ..
  42. Ríos Gutiérrez M, Chafaa F, Khorief Nacereddine A, Djerourou A, Domingo L. A DFT study of [3+2] cycloaddition reactions of an azomethine imine with N-vinyl pyrrole and N-vinyl tetrahydroindole. J Mol Graph Model. 2016;70:296-304 pubmed publisher
    ..Finally, electron localisation function (ELF) topological analysis allows characterising the mechanism of these 32CA reactions as a non-concerted two-stage one-..
  43. López I, Aroca F, Bernal M, Mompeán J, Bernal Ã, Martínez A, et al. Utility of the ELF Test for Detecting Steatohepatitis in Morbid Obese Patients with Suspicion of Nonalcoholic Fatty Liver Disease. Obes Surg. 2017;27:2347-2353 pubmed publisher
    ..The ELF test (Enhanced Liver Fibrosis test; Siemens Diagnostics, NY, USA) has been assessed for its capacity to detect ..
  44. Shoeman R, Hartig R, Hauses C, Traub P. Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease. Cell Biol Int. 2002;26:529-39 pubmed
    ..Control experiments demonstrated that the effect and protein cleavages described are due to action of the HIV-1 PR and not to the action of endogenous host cell proteases. ..
  45. Song Y, Antoniou C, Memic A, Kay B, Fung L. Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs. Protein Sci. 2011;20:867-79 pubmed publisher
  46. Kottou S, Nikolopoulos D, Yannakopoulos P, Vogiannis E, Petraki E, Panagiotaras D, et al. Preliminary background indoor EMF measurements in Greece. Phys Med. 2015;31:808-16 pubmed publisher
    ..The scientific interest is mainly focused on the bands of extremely low-frequency (ELF) magnetic fields and radiofrequency (RF) electric fields which have been suggested to be possibly carcinogenic to ..
  47. Freund F, Stolc V. Nature of Pre-Earthquake Phenomena and their Effects on Living Organisms. Animals (Basel). 2013;3:513-31 pubmed publisher
    ..Only ultralow and extremely low frequency (ULF/ELF) waves travel through rock and can reach the Earth surface...
  48. Safont V, González Navarrete P, Oliva M, Andrés J. Inquiry of the electron density transfers in chemical reactions: a complete reaction path for the denitrogenation process of 2,3-diazabicyclo[2.2.1]hept-2-ene derivatives. Phys Chem Chem Phys. 2015;17:32358-74 pubmed publisher
    ..visible pulse radiation and the quantum topological analysis of the electron localization function (ELF) in terms of breaking/forming processes along this chemical rearrangement...
  49. Bulik C, Okusanya O, Lakota E, Forrest A, Bhavnani S, Hoover J, et al. Pharmacokinetic-Pharmacodynamic Evaluation of Gepotidacin against Gram-Positive Organisms Using Data from Murine Infection Models. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..Plasma and epithelial lining fluid (ELF) PK data were best fit by a four-compartment model with linear distributional clearances, a capacity-limited ..
  50. N Guessan A, Fattal E, Chapron D, Gueutin C, Koffi A, Tsapis N. Dexamethasone palmitate large porous particles: A controlled release formulation for lung delivery of corticosteroids. Eur J Pharm Sci. 2018;113:185-192 pubmed publisher
    ..We observe that DXP remains for up to 6h in the epithelial lining fluid (ELF) of the lungs at very high concentration...
  51. Morales M, Liu Y, Laiakis E, Morgan W, Nimer S, Petrini J. DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions. Cancer Res. 2008;68:2186-93 pubmed publisher
    ..phenotype is mitigated when Rad50(S/S) is combined with mutations that alter either LSK cell quiescence (myeloid elf-1-like factor/ELF4-deficient mice) or hematopoietic differentiation (p21- and p27-deficient mice), indicating that ..
  52. Cañedo Dorantes L, Soenksen L, García Sánchez C, Trejo Núñez D, Pérez Chávez F, Guerrero A, et al. Efficacy and safety evaluation of systemic extremely low frequency magnetic fields used in the healing of diabetic foot ulcers--phase II data. Arch Med Res. 2015;46:470-8 pubmed publisher
    Cellular and animal models investigating extremely low frequency magnetic fields (ELF-MF) have reported promotion of leukocyte-endothelial interactions, angiogenesis, myofibroblast and keratinocyte proliferation, improvement of ..
  53. Hirschfield G, Gershwin M, Strauss R, Mayo M, Levy C, Zou B, et al. Ustekinumab for patients with primary biliary cholangitis who have an inadequate response to ursodeoxycholic acid: A proof-of-concept study. Hepatology. 2016;64:189-99 pubmed publisher
    ..67×-2.8× ULN) or <1.67× ULN (if baseline ALP >2.8× ULN). Changes in Enhanced Liver Fibrosis (ELF) scores and serum bile acids were also assessed. At baseline, patients had median disease duration of 3...
  54. Falone S, Marchesi N, Osera C, Fassina L, Comincini S, Amadio M, et al. Pulsed electromagnetic field (PEMF) prevents pro-oxidant effects of H2O2 in SK-N-BE(2) human neuroblastoma cells. Int J Radiat Biol. 2016;92:281-6 pubmed publisher
    ..may play a role in mediating some biological effects of extremely-low-frequency electromagnetic fields (ELF-EMF)...
  55. Domingo L, Ríos Gutiérrez M, Perez P. An MEDT study of the carbenoid-type [3 + 2] cycloaddition reactions of nitrile ylides with electron-deficient chiral oxazolidinones. Org Biomol Chem. 2016;14:10427-10436 pubmed
    ..Topological analysis of the Electron Localisation Function (ELF) of the NY shows that it presents a carbenoid structure...
  56. Zhu J, Zins E, Alikhani M. Characterization of B-H agostic compounds involved in the dehydrogenation of amine-boranes by group 4 metallocenes. J Mol Model. 2016;22:294 pubmed
    ..Topological approaches such as QTAIM and ELF revealed to be particularly suitable for the description of ?-agostic interactions...
  57. Yang H, Negishi K, Wang Y, Nolan M, Marwick T. Imaging-Guided Cardioprotective Treatment in a Community Elderly Population of Stage B Heart Failure. JACC Cardiovasc Imaging. 2017;10:217-226 pubmed publisher
    ..Tasmanian Study of Echocardiographic Detection of Left Ventricular Dysfunction [TAS-ELF]; ACTRN12614000080628).
  58. Holleran E, Tokito M, Karki S, Holzbaur E. Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles. J Cell Biol. 1996;135:1815-29 pubmed
    ..We suggest a model in which dynactin associates with the Golgi through an interaction between the centractin filament of the dynactin complex and a spectrin-linked cytoskeletal network. ..
  59. Duflos M, Goutx M, Van Wambeke F. Determination of lipid degradation by marine lipase-producing bacteria: critical evaluation of lipase activity assays. Lipids. 2009;44:1113-24 pubmed publisher
    ..In an enzymatic approach, lipase activities were measured using the fluorogenic lipid analogs MUF-palmitate and ELF-palmitate...
  60. Pham D, Grégoire N, Couet W, Gueutin C, Fattal E, Tsapis N. Pulmonary delivery of pyrazinamide-loaded large porous particles. Eur J Pharm Biopharm. 2015;94:241-50 pubmed publisher
    ..1±0.2μm and a geometric standard deviation (GSD) of 2.16±0.16. Plasma and epithelial lining fluid (ELF) concentrations of pyrazinamide were evaluated after intratracheal insufflation of PZA-LPPs (4...
  61. Yang G, Ren Z, Mei Y. Exposure to 50 Hz magnetic field modulates GABAA currents in cerebellar granule neurons through an EP receptor-mediated PKC pathway. J Cell Mol Med. 2015;19:2413-22 pubmed publisher
    Previous work from both our lab and others have indicated that exposure to 50 Hz magnetic fields (ELF-MF) was able to modify ion channel functions...
  62. Dong Y, Jiao S. CD133 induced tumorigenicity mice express TGF-beta receptor type II (TBRII) and embryonic liver fodrin (ELF) along with stem cell markers. Eur Rev Med Pharmacol Sci. 2016;20:2296-301 pubmed
    ..In this study, we compared the expression of CD133 along with TBRII and ELF using Immunohistochemistry and western blotting technique that probably helps to reveal the nature of cancer stem ..
  63. Taherpour A, Jamshidi M, Rezaei O. DFT and TD-DFT theoretical studies on photo-induced electron transfer process on [Cefamandole].C60 nano-complex. J Mol Graph Model. 2017;75:42-48 pubmed publisher
    ..The study of the interaction of C60 and Cefamandole via electron localization function (ELF) and reduced density gradient (RDG) revealed that the complex formation is of van der Waals type...
  64. Yan H, Han X, Zheng B. Pressure-Induced Phase Transition and Mechanical Properties of Mg?Sr Intermetallics. Materials (Basel). 2016;9: pubmed publisher
    ..The evidence of the bonding nature of Mg-Sr was also manifested by density of states (DOS) and electronic localization function (ELF) calculations.
  65. Bignone P, King M, Pinder J, Baines A. Phosphorylation of a threonine unique to the short C-terminal isoform of betaII-spectrin links regulation of alpha-beta spectrin interaction to neuritogenesis. J Biol Chem. 2007;282:888-96 pubmed
    ..Furthermore, because both the T2159E mutant and the wild-type allow neuritogenesis, we conclude that the short C-terminal betaII-spectrin is phosphorylated during this process. ..
  66. Omari E, Varghese T, Kliewer M, Harter J, Hartenbach E. Dynamic and quasi-static mechanical testing for characterization of the viscoelastic properties of human uterine tissue. J Biomech. 2015;48:1730-6 pubmed publisher
    ..the stiffness of normal uterine tissue, leiomyomas, and endometrial cancers using a EnduraTEC ElectroForce (ELF) system...
  67. Ferroni L, Tocco I, De Pieri A, Menarin M, Fermi E, Piattelli A, et al. Pulsed magnetic therapy increases osteogenic differentiation of mesenchymal stem cells only if they are pre-committed. Life Sci. 2016;152:44-51 pubmed publisher
    ..The aim of the present study was to characterize the effects of extremely low frequency (ELF)-PEMFs on commitment of mesenchymal stem cell (MSCs) culture system, through the determination of gene expression ..
  68. Hao H, Wang H, Chen L, Wu J, Qiu L, Rong L. Initial Results from SQUID Sensor: Analysis and Modeling for the ELF/VLF Atmospheric Noise. Sensors (Basel). 2017;17: pubmed publisher
    In this paper, the amplitude probability density (APD) of the wideband extremely low frequency (ELF) and very low frequency (VLF) atmospheric noise is studied...
  69. Sanyal A, Cusi K, Hartman M, Zhang S, Bastyr E, Bue Valleskey J, et al. Cytokeratin-18 and enhanced liver fibrosis scores in type 1 and type 2 diabetes and effects of two different insulins. J Investig Med. 2017;: pubmed publisher
    Data on cytokeratin-18 (K-18) and enhanced liver fibrosis (ELF) score in insulin-treated diabetes patients with non-alcoholic fatty liver disease (NAFLD) are limited...
  70. Cao X, Wan L, Xiao J, Chen X, Zhou Y, Wang Z, et al. Environmental effects by introducing Potamogeton crispus to recover a eutrophic Lake. Sci Total Environ. 2018;621:360-367 pubmed publisher
    ..Peridiniopsis excreted phosphatase as evidence by simultaneously in situ enzyme labelled fluorescence (ELF) labelling and main alkaline phosphatase activity contributed by large particles, suggesting that the dominance of ..
  71. González Navarrete P, Andrés J, Safont V. A bonding evolution analysis for the thermal Claisen rearrangement: an experimental and theoretical exercise for testing the electron density flow. Phys Chem Chem Phys. 2017;20:535-541 pubmed publisher
    ..We present the use of the electron localization function (ELF) to monitor the bonding evolution aspects in the course of this thermal rearrangement and the results are compared ..
  72. Oh Y, Fung L. Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin. Cell Mol Biol Lett. 2007;12:604-20 pubmed
    ..Future structural and functional studies of these proteins to provide interaction mechanisms will no doubt lead to a better understanding of brain physiology and pathophysiology. ..
  73. Li P, Niu W, Gao T. Systematic analysis of structural and spectroscopic properties of neptunimine (HN=NpH2) and plutonimine (HN=PuH2). J Mol Model. 2015;21:316 pubmed publisher
    ..in these molecules were investigated by employing topological methods including electron localization function (ELF), atoms in molecules (AIM) as well as natural bond orbital analysis (NBO)...
  74. Pradhan D, Lombardo C, Roe S, Rimm D, Morrow J. alpha -Catenin binds directly to spectrin and facilitates spectrin-membrane assembly in vivo. J Biol Chem. 2001;276:4175-81 pubmed
  75. Bignone P, Baines A. Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site. Biochem J. 2003;374:613-24 pubmed
  76. Robb V, Li W, Gutmann D. Disruption of 14-3-3 binding does not impair Protein 4.1B growth suppression. Oncogene. 2004;23:3589-96 pubmed
    ..Collectively, these results suggest that binding to 14-3-3 is not essential for the growth suppressor function of Protein 4.1B in meningiomas. ..
  77. Kizhatil K, Davis J, Davis L, Hoffman J, Hogan B, Bennett V. Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. J Biol Chem. 2007;282:26552-61 pubmed
    ..Biol. Chem. 282, 2029-2037 ). Together with the current findings, these data suggest a ankyrin/spectrin-based mechanism for coordinating membrane assembly with extracellular interactions of E-cadherin at sites of cell-cell contact. ..
  78. Sevinc A, Fung L. Non-erythroid beta spectrin interacting proteins and their effects on spectrin tetramerization. Cell Mol Biol Lett. 2011;16:595-609 pubmed publisher
    ..We also found that the syntaxin binding protein 1 fragment abolished ?II-N and ?II-C interaction, suggesting that this protein may inhibit or regulate non-erythroid spectrin tetramer formation. ..
  79. Moayyeri A, Hsu Y, Karasik D, Estrada K, Xiao S, Nielson C, et al. Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Hum Mol Genet. 2014;23:3054-68 pubmed publisher
    ..1: rs4869739, rs3020331, rs2982552), sptbn1 (2p16.2: rs11898505), rspo3 (6q22.33: rs7741021), wnt16 (7q31.31: rs2908007), dkk1 (10q21...
  80. Smith S, Sturm A, Curran J, Kline C, Little S, Bonilla I, et al. Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia. Circulation. 2015;131:695-708 pubmed publisher
    ..Our findings identify βII spectrin as critical for normal myocyte electric activity, link this molecule to human disease, and provide new insight into the mechanisms underlying cardiac myocyte biology. ..
  81. Rezaei Kanavi M, Tabeie F, Sahebjam F, Poursani N, Jahanbakhsh N, Paymanpour P, et al. Short-term effects of extremely low-frequency pulsed electromagnetic field and pulsed low-level laser therapy on rabbit model of corneal alkali burn. Exp Eye Res. 2016;145:216-223 pubmed publisher
    ..This study was conducted to investigate the effect of combining extremely low frequency-pulsed electromagnetic field (ELF-PEMF) and low-level laser therapy (LLLT) on alkali-burned rabbit corneas...
  82. Djinovic Carugo K, Banuelos S, Saraste M. Crystal structure of a calponin homology domain. Nat Struct Biol. 1997;4:175-9 pubmed
    ..The three-dimensional structure of the calponin homology domain present in many actin binding cytoskeletal and signal-transducing proteins has been determined at 2.0 A resolution. ..
  83. Oshikawa M, Sugai Y, Usami R, Ohtoko K, Toyama S, Kato S. Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method. DNA Res. 2008;15:123-36 pubmed publisher
  84. Tyvold S, Dahl T, Dragsund S, Gunnes S, Lyng O, Damås J, et al. Bronchial microdialysis monitoring of inflammatory response in open abdominal aortic aneurysm repair; an observational study. Physiol Rep. 2017;5: pubmed publisher
    ..to evaluate bronchial microdialysis as a continuous monitoring of cytokines in bronchial epithelial lining fluid (ELF) and to determine whether bronchial ELF cytokine levels reflect the ischemia-reperfusion injury and risk for ..
  85. Miele L, De Michele T, Marrone G, Antonietta Isgrò M, Basile U, Cefalo C, et al. Enhanced liver fibrosis test as a reliable tool for assessing fibrosis in nonalcoholic fatty liver disease in a clinical setting. Int J Biol Markers. 2017;32:e397-e402 pubmed publisher
    ..The aim of this study was to investigate the diagnostic accuracy of the commercial enhanced liver fibrosis (ELF) test manufacturer's cutoff value (?9...
  86. Falone S, Santini S, Cordone V, Cesare P, Bonfigli A, Grannonico M, et al. Power frequency magnetic field promotes a more malignant phenotype in neuroblastoma cells via redox-related mechanisms. Sci Rep. 2017;7:11470 pubmed publisher
    ..the classification of the International Agency for Research on Cancer, extremely low frequency magnetic fields (ELF-MF) are suspected to promote malignant progression by providing survival advantage to cancer cells through the ..
  87. Heo J, Kim B, Park J, Kim D, Ahn S, Kim H, et al. Combination of Transient Elastography and an Enhanced Liver Fibrosis Test to Assess the Degree of Liver Fibrosis in Patients with Chronic Hepatitis B. Gut Liver. 2017;: pubmed publisher
    Liver stiffness (LS) was assessed using transient elastography, and the enhanced liver fibrosis (ELF) test was performed to accurately assess fibrotic burden...
  88. Laszlo A, Ladányi M, Boda K, Csicsman J, Bari F, Serester A, et al. Effects of extremely low frequency electromagnetic fields on turkeys. Poult Sci. 2017;: pubmed publisher
    ..of electromagnetic fields (EMF) on birds; however, little attention has been paid to the extremely low frequency (ELF; 0-300 Hz; 0-50 ?T) radiation found in an urbanized environment...
  89. Peet J, Piovano A, Johnson M, Evans I. Location and orientation of lone pairs in apatite-type materials: a computational study. Dalton Trans. 2017;46:15996-15999 pubmed publisher
    Electron localisation function (ELF) calculations have been used to provide the first computational location of the cation lone pairs in apatite materials...
  90. Uchida A, Samukawa T, Kumamoto T, Ohshige M, Hatanaka K, Nakamura Y, et al. Napsin A levels in epithelial lining fluid as a diagnostic biomarker of primary lung adenocarcinoma. BMC Pulm Med. 2017;17:195 pubmed publisher
    ..To this end, we evaluated levels of napsin A in epithelial lining fluid (ELF), since napsin A has been reported to be an immunohistochemical biomarker for histological diagnosis of primary ..
  91. Nebl T, Pestonjamasp K, Leszyk J, Crowley J, Oh S, Luna E. Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes. J Biol Chem. 2002;277:43399-409 pubmed
    ..We suggest that the DRM-H fraction represents a membrane skeleton-associated subset of leukocyte signaling domains. ..
  92. Lee H, Lee K, Im H. ?-Synuclein modulates neurite outgrowth by interacting with SPTBN1. Biochem Biophys Res Commun. 2012;424:497-502 pubmed publisher
    ..In this study, spectrin beta non-erythrocyte 1 (SPTBN1) interacted with ?-synuclein in phage display assays using a normalized human brain cDNA library...