Gene Symbol: SPTB
Description: spectrin beta, erythrocytic
Alias: EL3, HS2, HSPTB1, SPH2, spectrin beta chain, erythrocytic, Sp beta, beta-I spectrin, membrane cytoskeletal protein, spectrin beta Tandil, spectrin beta chain, erythrocyte
Species: human
Products:     SPTB

Top Publications

  1. Bennett V, Stenbuck P. The membrane attachment protein for spectrin is associated with band 3 in human erythrocyte membranes. Nature. 1979;280:468-73 pubmed
    ..It is concluded that a fraction of band 3 is attached to the erythrocyte cytoskeleton through association with ankyrin, which in turn is bound to spectrin. ..
  2. Winkelmann J, Chang J, Tse W, Scarpa A, Marchesi V, Forget B. Full-length sequence of the cDNA for human erythroid beta-spectrin. J Biol Chem. 1990;265:11827-32 pubmed
    ..Combining knowledge of spectrin primary structure with previously reported functional studies, it is possible to make several inferences regarding structure/function relationships within the beta-spectrin molecule. ..
  3. Bennett V, Baines A. Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. Physiol Rev. 2001;81:1353-92 pubmed
    ..Exciting questions for the future relate to the molecular basis for these pathways and their roles in a clinical context, either as the basis for disease or more positively as therapeutic targets...
  4. Pradhan D, Morrow J. The spectrin-ankyrin skeleton controls CD45 surface display and interleukin-2 production. Immunity. 2002;17:303-15 pubmed
    ..3 +/- 3.0 nM). These data reveal a novel and unexpected contribution of the spectrin-ankyrin skeleton to the control of T lymphocyte function. ..
  5. An X, Debnath G, Guo X, Liu S, Lux S, Baines A, et al. Identification and functional characterization of protein 4.1R and actin-binding sites in erythrocyte beta spectrin: regulation of the interactions by phosphatidylinositol-4,5-bisphosphate. Biochemistry. 2005;44:10681-8 pubmed
    ..1R ternary complex in vitro. Furthermore, the binding of 4.1R to 1-301 is greatly enhanced by PIP(2), implying the existence of a regulatory switch in the cell. ..
  6. Czogalla A, Jaszewski A, Diakowski W, Bok E, Jezierski A, Sikorski A. Structural insight into an ankyrin-sensitive lipid-binding site of erythroid beta-spectrin. Mol Membr Biol. 2007;24:215-24 pubmed
    ..A model based on the obtained data provides direct evidence that the examined lipid-binding site is a highly amphipathic helix, which is correlated with the specific conformation of its N-terminal fragment. ..
  7. Ipsaro J, Huang L, MONDRAGON A. Structures of the spectrin-ankyrin interaction binding domains. Blood. 2009;113:5385-93 pubmed publisher
    ..Previously reported mutants of ankyrin that map to this region lie mostly on the surface of the protein, although at least one is likely to be part of the core. ..
  8. Stabach P, Simonovic I, Ranieri M, Aboodi M, Steitz T, Simonovic M, et al. The structure of the ankyrin-binding site of beta-spectrin reveals how tandem spectrin-repeats generate unique ligand-binding properties. Blood. 2009;113:5377-84 pubmed publisher
    ..The putative coupling of flexibility and ligand binding suggests a mechanism by which spectrin might participate in mechanosensory regulation. ..
  9. Siddam A, Gautier Courteille C, Perez Campos L, Anand D, Kakrana A, Dang C, et al. The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development. PLoS Genet. 2018;14:e1007278 pubmed publisher
    ..Thus, we illustrate new Celf1-regulated molecular mechanisms in lens development, suggesting that post-transcriptional regulatory RNA-binding proteins have evolved conserved functions to control vertebrate oculogenesis. ..

More Information

Publications186 found, 100 shown here

  1. Liang Z, Lu Y, Qian Y, Zhu L, Kuang S, Chen F, et al. Cultured cells and wing disc size of silkworm can be controlled by the Hippo pathway. Open Biol. 2018;8: pubmed publisher
    ..01); KEGG analysis showed that the up/downregulated genes were enriched in 49/101 pathways. These findings provided novel information to understand the functions of BmYki3 in a cell proliferation and organ-size control pathway. ..
  2. Ying J, Lin C, Wu J, Guo L, Qiu T, Ling Y, et al. Anaplastic Lymphoma Kinase Rearrangement in Digestive Tract Cancer: Implication for Targeted Therapy in Chinese Population. PLoS ONE. 2015;10:e0144731 pubmed publisher
    ..44%,but not detectable in gastric and esophageal cancers. The novel SPTBN1 -ALK fusion, together with other ALK fusion genes, may become a potential target for anti-ALK therapy. ..
  3. Bogusławska D, Machnicka B, Hryniewicz Jankowska A, Czogalla A. Spectrin and phospholipids - the current picture of their fascinating interplay. Cell Mol Biol Lett. 2014;19:158-79 pubmed publisher
    ..In this review, we summarize the state of knowledge about interactions between spectrin and membrane lipids. ..
  4. Gu F, Zhang Y, Liu Y, Hong X, Liang J, Tong F, et al. Lung adenocarcinoma harboring concomitant SPTBN1-ALK fusion, c-Met overexpression, and HER-2 amplification with inherent resistance to crizotinib, chemotherapy, and radiotherapy. J Hematol Oncol. 2016;9:66 pubmed publisher
    ..In addition, the novel SPTBN1-ALK fusion gene may become a potential target for anti-tumor therapy. ..
  5. Sironi M, Forni D, Clerici M, Cagliani R. Genetic conflicts with Plasmodium parasites and functional constraints shape the evolution of erythrocyte cytoskeletal proteins. Sci Rep. 2018;8:14682 pubmed publisher
    ..Conversely, several genes, including ANK1 and SPTB, displayed extensive signatures of purifying selection in primate phylogenies, Homininae lineages, and human ..
  6. Jacko M, Weyn Vanhentenryck S, Smerdon J, Yan R, Feng H, Williams D, et al. Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly. Neuron. 2018;97:853-868.e6 pubmed publisher
    ..Our data show that the Rbfox-regulated splicing program plays a crucial role in structural and functional maturation of postmitotic neurons. ..
  7. Zuccala E, Satchwell T, Angrisano F, Tan Y, Wilson M, Heesom K, et al. Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton. Sci Rep. 2016;6:19766 pubmed publisher
    ..This provides the first evidence that the erythrocyte is stimulated to respond to early invasion events through molecular changes in its membrane architecture. ..
  8. Perez L, Patel U, Rivota M, Calin Jageman I, Calin Jageman R. Savings memory is accompanied by transcriptional changes that persist beyond the decay of recall. Learn Mem. 2018;25:45-48 pubmed publisher
    ..The small set of transcriptional changes that persist could mediate the rapid relearning of the memory (savings), or the decay of recall, or both, or neither...
  9. Terawaki S, Kitano K, Mori T, Zhai Y, Higuchi Y, Itoh N, et al. The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module. EMBO J. 2010;29:236-50 pubmed publisher
    ..Our results suggest the molecular basis by which the Tiam1/2 PHCCEx domain facilitates dual binding to membranes and signalling proteins. ..
  10. Wang Y, Koh K, Miwa M, Yamashiro N, Shindo K, Takiyama Y. A Japanese SCA5 family with a novel three-nucleotide in-frame deletion mutation in the SPTBN2 gene: a clinical and genetic study. J Hum Genet. 2014;59:569-73 pubmed publisher
    ..This is the first three-nucleotide in-frame deletion mutation in this region of the beta-3 spectrin protein highly likely to be pathogenic based on exome and bioinformatic data. ..
  11. Murphy S, Zweyer M, Henry M, Meleady P, Mundegar R, Swandulla D, et al. Proteomic analysis of the sarcolemma-enriched fraction from dystrophic mdx-4cv skeletal muscle. J Proteomics. 2019;191:212-227 pubmed publisher
    ..In order to evaluate secondary changes in the sarcolemma membrane system due to the lack of the membrane cytoskeletal protein dystrophin, comparative organellar proteomics was used to study the mdx-4cv mouse model of ..
  12. Mehboob S, Song Y, Witek M, Long F, Santarsiero B, Johnson M, et al. Crystal structure of the nonerythroid alpha-spectrin tetramerization site reveals differences between erythroid and nonerythroid spectrin tetramer formation. J Biol Chem. 2010;285:14572-84 pubmed publisher
    ..Mutations leading to reduced levels of functional tetramers in cells may potentially lead to abnormal neuronal functions. ..
  13. Murphy S, Zweyer M, Mundegar R, Henry M, Meleady P, Swandulla D, et al. Concurrent Label-Free Mass Spectrometric Analysis of Dystrophin Isoform Dp427 and the Myofibrosis Marker Collagen in Crude Extracts from mdx-4cv Skeletal Muscles. Proteomes. 2015;3:298-327 pubmed publisher
    ..using whole tissue proteomics we show here for the first time that the reduced expression of this membrane cytoskeletal protein is the most significant alteration in dystrophinopathy...
  14. Murphy S, Zweyer M, Raucamp M, Henry M, Meleady P, Swandulla D, et al. Proteomic profiling of the mouse diaphragm and refined mass spectrometric analysis of the dystrophic phenotype. J Muscle Res Cell Motil. 2019;: pubmed publisher
    ..The detailed pathoproteomic profiling of the mdx-4cv diaphragm suggests highly complex alterations in a variety of crucial cellular processes due to deficiency in the membrane cytoskeletal protein dystrophin.
  15. Yang R, Liang S, Flick L, Yang S, Hu K, Wang J, et al. Relationship Between Common Mental Disorder Symptoms During Pregnancy and Preterm Birth Among Chinese Women in Wuhan. Matern Child Health J. 2016;20:2121-9 pubmed publisher
    ..3 %. The incidence of PTB in Wuhan was 4.5 %. Spontaneous preterm births (SPTB) accounted for 60.1 %, and medically induced preterm births (IPTB) accounted for 39.9 % of preterm births...
  16. Chu N, Wu Z, Zhang X, Fang S, Wang W, Cheng Y. Molecular mechanism of yisui shengxue granule, a complex chinese medicine, on thalassemia patients suffering from hemolysis and anemia of erythrocytes. Evid Based Complement Alternat Med. 2014;2014:213782 pubmed publisher
    ..For all patients, RT-PCR showed that YSSXG upregulated mRNA expression of SPTA1 and SPTB. Activities of SOD and GSH-Px significantly increased and MDA obviously reduced on erythrocyte and blood serum ..
  17. Vink J, Mourad M. The pathophysiology of human premature cervical remodeling resulting in spontaneous preterm birth: Where are we now?. Semin Perinatol. 2017;41:427-437 pubmed publisher
    ..In order to decrease the rate of spontaneous preterm birth (sPTB), it is imperative that we improve our understanding of normal and abnormal reproductive tissue structure and ..
  18. Murphy S, Ohlendieck K. Proteomic Profiling of the Dystrophin-Deficient Brain. Methods Mol Biol. 2018;1687:91-105 pubmed publisher
    ..highly progressive neuromuscular disorder caused by primary abnormalities in the Dmd gene encoding the membrane cytoskeletal protein dystrophin...
  19. Liu X, Zhou Q, Ji Z, Fu G, Li Y, Zhang X, et al. Protein 4.1R attenuates autoreactivity in experimental autoimmune encephalomyelitis by suppressing CD4(+) T cell activation. Cell Immunol. 2014;292:19-24 pubmed publisher
    ..Protein 4.1R, a red cell membrane cytoskeletal protein, recently was identified as an important component of immunological synapse (IS) and acted as the ..
  20. Suhag A, Berghella V. Short cervical length dilemma. Obstet Gynecol Clin North Am. 2015;42:241-54 pubmed publisher
    ..In asymptomatic singletons without prior spontaneous PTB (sPTB), TVU CL screening should be done. If the cervix is 20 mm or less, vaginal progesterone is indicated...
  21. Son M, Miller E. Predicting preterm birth: Cervical length and fetal fibronectin. Semin Perinatol. 2017;41:445-451 pubmed publisher
    ..relies on their ability to accurately predict those pregnancies at increased risk for spontaneous preterm birth (SPTB)...
  22. McFarlin B, Kumar V, Bigelow T, Simpson D, White Traut R, Abramowicz J, et al. Beyond Cervical Length: A Pilot Study of Ultrasonic Attenuation for Early Detection of Preterm Birth Risk. Ultrasound Med Biol. 2015;41:3023-9 pubmed publisher
    ..Cervical ultrasonic attenuation was lower at 17-21 wk of gestation in the SPTB group (1.02 dB/cm-MHz) than in the full-term birth groups (1.34 dB/cm-MHz) (p = 0.04)...
  23. Zhao H, Wang C, Yao L, Lin Q, Xu X, Hu L, et al. Identification of aged bloodstains through mRNA profiling: Experiments results on selected markers of 30- and 50-year-old samples. Forensic Sci Int. 2017;272:e1-e6 pubmed publisher
    ..e. HBB, HBA, GYPA, CD93, ALAS2, SPTB (91bp and 247bp primers), and PBGD...
  24. Cavoretto P, Candiani M, Giorgione V, Inversetti A, Abu Saba M, Tiberio F, et al. IVF/ICSI treatment and the risk of spontaneous preterm birth in singleton pregnancies: a meta-analysis of cohort studies. Ultrasound Obstet Gynecol. 2017;: pubmed publisher
    ..This study quantifies the risk of spontaneous preterm birth (SPTB) in singleton pregnancies resulting from IVF as compared to spontaneous conception.
  25. Younger J, Reitman E, Gallos G. Tocolysis: Present and future treatment options. Semin Perinatol. 2017;41:493-504 pubmed publisher
    ..Moving forward, we must incorporate the emerging molecular data that is amassing in order to develop novel and effective tocolytic therapeutic options to prevent preterm labor and spontaneous preterm birth (sPTB).
  26. Caradeux J, Murillo C, Julià C, Escura S, Ferrero S, Cobo T, et al. Follow-Up of Asymptomatic High-Risk Patients with Normal Cervical Length to Predict Recurrence of Preterm Birth. Fetal Diagn Ther. 2019;45:50-56 pubmed publisher
    A midtrimester cervical length (CL) <25 mm is associated with spontaneous preterm birth (sPTB)...
  27. Radford S, da Silva Costa F, Araujo Júnior E, Sheehan P. Clinical Application of Quantitative Foetal Fibronectin for the Prediction of Preterm Birth in Symptomatic Women. Gynecol Obstet Invest. 2017;: pubmed publisher
    ..the clinical application of the new Hologic quantitative foetal fibronectin (qfFN) bedside test for the prediction of spontaneous preterm birth (sPTB) in patients with symptoms suggestive of spontaneous threatened preterm labour (sPTL).
  28. Speicher D, Weglarz L, DeSilva T. Properties of human red cell spectrin heterodimer (side-to-side) assembly and identification of an essential nucleation site. J Biol Chem. 1992;267:14775-82 pubmed
    ..Assembly is terminated if either polypeptide is interrupted by a protease cleavage. Heterozygotic mutations involving either nucleation site are predicted to affect allele incorporation into the mature membrane skeleton. ..
  29. Leshchyns ka I, Sytnyk V, Morrow J, Schachner M. Neural cell adhesion molecule (NCAM) association with PKCbeta2 via betaI spectrin is implicated in NCAM-mediated neurite outgrowth. J Cell Biol. 2003;161:625-39 pubmed
    ..Furthermore, transfection with betaI2-3 inhibits NCAM-induced neurite outgrowth, showing that formation of the NCAM-spectrin-PKCbeta2 complex is necessary for NCAM-mediated neurite outgrowth. ..
  30. Wang L. Value of serial cervical length measurement in prediction of spontaneous preterm birth in post-conization pregnancy without short mid-trimester cervix. Sci Rep. 2018;8:15305 pubmed publisher
    ..in mid-trimester is recommended in post-conization pregnancy to estimate the risk of spontaneous preterm birth (SPTB). A short mid-trimester cervix (CL < 25 mm) has been considered as a strong predictor for SPTB...
  31. Baños N, Murillo Bravo C, Julia C, Migliorelli F, Pérez Moreno A, Rios J, et al. Mid-trimester sonographic cervical consistency index to predict spontaneous preterm birth in a low-risk population. Ultrasound Obstet Gynecol. 2018;51:629-636 pubmed publisher
    ..of mid-trimester sonographic cervical consistency index (CCI) for the prediction of spontaneous preterm birth (sPTB) in low-risk pregnancies and to compare its performance with that of mid-trimester sonographic cervical-length (CL) ..
  32. Dugoff L, Berghella V, Sehdev H, MacKeen A, Goetzl L, Ludmir J. Prevention of preterm birth with pessary in singletons (PoPPS): randomized controlled trial. Ultrasound Obstet Gynecol. 2018;51:573-579 pubmed publisher
    ..with short cervical length (CL) measured on transvaginal sonography (TVS) and without prior spontaneous PTB (sPTB)...
  33. Sykes L, Bennett P. Efficacy of progesterone for prevention of preterm birth. Best Pract Res Clin Obstet Gynaecol. 2018;52:126-136 pubmed publisher
    ..Although the exact mechanisms that lead to spontaneous PTB (sPTB) are not fully understood, it is likely that the terminal pathways that are common to term labour are activated ..
  34. Coetzer T, Palek J, Lawler J, Liu S, Jarolim P, Lahav M, et al. Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis. Blood. 1990;75:2235-44 pubmed
    ..These data demonstrate striking differences in the function and structure of various alpha Sp mutants that underlie differences in clinical expression. ..
  35. Amabebe E, Chapman D, Stern V, Stafford G, Anumba D. Mid-gestational changes in cervicovaginal fluid cytokine levels in asymptomatic pregnant women are predictive markers of inflammation-associated spontaneous preterm birth. J Reprod Immunol. 2018;126:1-10 pubmed publisher
    Perturbation of the choriodecidual space before the onset of spontaneous preterm birth (sPTB) could lead to a concomitant rise in both cervicovaginal fluid (CVF) cytokine and fetal fibronectin (FFN), and assessing the concentrations of ..
  36. Luo X, Pan J, Wang L, Wang P, Zhang M, Liu M, et al. Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes. BMC Pregnancy Childbirth. 2015;15:35 pubmed publisher
    ..Here, we further investigated the relationship of lncRNAs, which are differentially expressed in spontaneous PTB (sPTB) and PPROM placentas and are found to overlap a coding locus, with the differential expression of transcribed mRNAs ..
  37. Eidem H, Rinker D, Ackerman W, Buhimschi I, Buhimschi C, Dunn Fletcher C, et al. Comparing human and macaque placental transcriptomes to disentangle preterm birth pathology from gestational age effects. Placenta. 2016;41:74-82 pubmed publisher
    A major issue in the transcriptomic study of spontaneous preterm birth (sPTB) in humans is the inability to collect healthy control tissue at the same gestational age (GA) to compare with pathologic preterm tissue...
  38. Khin N, Lowe J, Jensen L, Burgio G. No evidence for genome editing in mouse zygotes and HEK293T human cell line using the DNA-guided Natronobacterium gregoryi Argonaute (NgAgo). PLoS ONE. 2017;12:e0178768 pubmed publisher
    ..We assessed this claim in mouse zygotes for four loci (Sptb, Tet-1, Tet-2 and Tet-3) and in the human HEK293T cell line for the EMX1 locus...
  39. Lin P, Chiou S, Lin C, Wang S, Huang H, Chang Y, et al. Whole-exome sequencing for the genetic diagnosis of congenital red blood cell membrane disorders in Taiwan. Clin Chim Acta. 2018;487:311-317 pubmed publisher
    ..Five causative variants, including two ANK1, two SPTA and one SPTB variants, were detected in four patients. All these variants, except one SPTA1 variant c.83G > A (p...
  40. Kanzaki A, Rabodonirina M, Yawata Y, Wilmotte R, Wada H, Ata K, et al. A deletional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin Tokyo (beta 220/216). Blood. 1992;80:2115-21 pubmed
    ..However, for some reason, Spectrin Tokyo had a lower incorporation level into the membrane than Spectrin Nice. ..
  41. Gallagher P, Tse W, Costa F, Scarpa A, Boivin P, Delaunay J, et al. A splice site mutation of the beta-spectrin gene causing exon skipping in hereditary elliptocytosis associated with a truncated beta-spectrin chain. J Biol Chem. 1991;266:15154-9 pubmed
    ..A new in-frame stop codon is encountered following a single residue of this novel sequence. ..
  42. Subramaniam A, Wetta L, Owen J. Relationship between interpregnancy interval and cervical length in high-risk women. J Matern Fetal Neonatal Med. 2016;29:1205-8 pubmed publisher
    ..next-pregnancy mid-trimester cervical length (CL) in women at high risk for recurrent spontaneous preterm birth (SPTB)...
  43. Holland A, Carberry S, Ohlendieck K. Proteomics of the dystrophin-glycoprotein complex and dystrophinopathy. Curr Protein Pept Sci. 2013;14:680-97 pubmed
    ..4 million bases, which encodes for the membrane cytoskeletal protein dystrophin...
  44. Esplin M, Manuck T, Varner M, Christensen B, Biggio J, Bukowski R, et al. Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms. Am J Obstet Gynecol. 2015;213:429.e1-9 pubmed publisher
    ..is based on common biologic pathways to identify specific phenotypes among women with spontaneous preterm birth (SPTB) to enhance investigators' ability to identify and to highlight common mechanisms and underlying genetic factors ..
  45. Gallagher P, Petruzzi M, Weed S, Zhang Z, Marchesi S, Mohandas N, et al. Mutation of a highly conserved residue of betaI spectrin associated with fatal and near-fatal neonatal hemolytic anemia. J Clin Invest. 1997;99:267-77 pubmed
    ..This mutation must also be expressed in the betaIsigma2 spectrin found in muscle, yet pathologic and immunohistochemical examination of skeletal muscle from the deceased sibling was unremarkable. ..
  46. Davis L, Bennett V. Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin. J Biol Chem. 1990;265:10589-96 pubmed
    ..The finding that the 33-amino acid repeating sequence is involved in interaction with the anion exchanger implies that this motif may perform a role in molecular recognition in diverse proteins. ..
  47. Andraweera P, Dekker G, Leemaqz S, McCowan L, Roberts C. The obesity associated FTO gene variant and the risk of adverse pregnancy outcomes: Evidence from the SCOPE study. Obesity (Silver Spring). 2016;24:2600-2607 pubmed publisher
    ..pre-eclampsia, gestational hypertension, small for gestational age pregnancy (SGA), and spontaneous preterm birth (sPTB). A case-control study of 1,741 nulliparous Caucasian women, their partners, and infants was conducted...
  48. Palatnik A, Miller E, Son M, Kominiarek M. Association among Maternal Obesity, Cervical Length, and Preterm Birth. Am J Perinatol. 2017;34:471-479 pubmed publisher
    ..with the inverse relationship between maternal body mass index (BMI) at delivery and spontaneous preterm birth (SPTB)...
  49. Buck J, Orzechowski K, Berghella V. Racial disparities in cervical length for prediction of preterm birth in a low risk population. J Matern Fetal Neonatal Med. 2017;30:1851-1854 pubmed publisher
    Racial minorities experience higher rates of spontaneous preterm birth (sPTB). Our objective was to evaluate whether there are racial discrepancies in the incidence of second trimester short cervical length (≤25 mm)...
  50. Talati A, Hackney D, Mesiano S. Pathophysiology of preterm labor with intact membranes. Semin Perinatol. 2017;41:420-426 pubmed publisher
    Preterm labor with intact membranes is a major cause of spontaneous preterm birth (sPTB). To prevent sPTB a clear understanding is needed of the hormonal interactions that initiate labor...
  51. Saccone G, Berghella V, Venturella R, D Alessandro P, Arduino B, Raffone A, et al. Effects of exercise during pregnancy in women with short cervix: Secondary analysis from the Italian Pessary Trial in singletons. Eur J Obstet Gynecol Reprod Biol. 2018;229:132-136 pubmed publisher
    ..effects of exercise during pregnancy in asymptomatic singleton pregnancies without prior spontaneous preterm birth (SPTB) but with short transvaginal ultrasound cervical length (TVU CL)...
  52. Leemaqz S, Dekker G, McCowan L, Kenny L, Myers J, Simpson N, et al. Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications. Reprod Toxicol. 2016;62:77-86 pubmed publisher
    ..278 Preeclampsia, 470 gestational hypertension, 633 small-for-gestational-age, 236 spontaneous preterm births (SPTB), 143 gestational diabetes] were compared separately with 4114 non-cases...
  53. Buck J, Orzechowski K, Baxter J, Berghella V. Cervical length in adolescents versus adults. J Matern Fetal Neonatal Med. 2018;31:603-606 pubmed publisher
    Two of the known risk factors for spontaneous preterm birth (sPTB) are short cervical length (CL)???25?mm and adolescence (?19?years)...
  54. Wang R, Yang S, Xu M, Huang J, Liu H, Gu W, et al. Exome sequencing confirms molecular diagnoses in 38 Chinese families with hereditary spherocytosis. Sci China Life Sci. 2018;61:947-953 pubmed publisher
    ..Five causative genes (ANK1, SPTB, SPTA1, SLC4A1, and EPB42) have been identified...
  55. Thomas M, Sulek K, McKenzie E, Jones B, Han T, Villas Boas S, et al. Metabolite Profile of Cervicovaginal Fluids from Early Pregnancy Is Not Predictive of Spontaneous Preterm Birth. Int J Mol Sci. 2015;16:27741-8 pubmed publisher
    ..metabolomic approach to search for biomarkers that may act as early indicators of spontaneous preterm birth (sPTB)...
  56. Bogusławska D, Heger E, Machnicka B, Skulski M, Kuliczkowski K, Sikorski A. A new frameshift mutation of the ?-spectrin gene associated with hereditary spherocytosis. Ann Hematol. 2017;96:163-165 pubmed publisher
  57. Kamphuis E, Ravelli A, Koullali B, Kazemier B, de Groot C, Mol B. Spontaneous and iatrogenic preterm birth rates among unselected women in three consecutive pregnancies. Eur J Obstet Gynecol Reprod Biol. 2018;228:92-97 pubmed publisher
    To assess the risk of sPTB and iPTB in women with three consecutive singleton pregnancies and the impact of the outcome of the 1st and 2nd pregnancy on the (recurrent) PTB risk in the 3rd pregnancy...
  58. Pasquini L, Sisti G, Nasioudis D, Kanninen T, Sorbi F, Fambrini M, et al. Ability of cervical length to predict spontaneous preterm delivery in twin pregnancies using the receiver-operating characteristic curve analysis and an a priori cut-off value. J Obstet Gynaecol. 2017;37:562-565 pubmed publisher
    ..between 20 and 24 + 6 weeks, we examined the ability of CL to predict spontaneous preterm birth (SPTB) in 222 twin pregnancies using the receiver-operating curve (ROC) analysis and an a priori cut-off...
  59. Andraweera P, Roberts C, Leemaqz S, McCowan L, Myers J, Kenny L, et al. The duration of sexual relationship and its effects on adverse pregnancy outcomes. J Reprod Immunol. 2018;128:16-22 pubmed publisher
    ..hypertension (GHT), preeclampsia, small for gestational age (SGA) pregnancies and spontaneous preterm birth (sPTB) with or without abnormal uterine artery Doppler compared to women who have uncomplicated pregnancies...
  60. Roman A, Saccone G, Dude C, Ward A, Anastasio H, Dugoff L, et al. Midtrimester transvaginal ultrasound cervical length screening for spontaneous preterm birth in diamniotic twin pregnancies according to chorionicity. Eur J Obstet Gynecol Reprod Biol. 2018;229:57-63 pubmed publisher
    ..The relationship of TVU CL with gestational age (GA) at delivery and incidence of spontaneous preterm birth (SPTB) at different TVU CL cut offs were assessed...
  61. Peng W, Yang X, Zhu L, Zhang X, Wang Y. [Association between tumor necrosis factor-? G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth]. Zhongguo Dang Dai Er Ke Za Zhi. 2016;18:1247-1253 pubmed
    ..tumor necrosis factor-? (TNF-?) G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth (SPTB). The case group enrolled 753 SPTB infants and the control group included 681 term infants...
  62. Murphy S, Ohlendieck K. Mass spectrometric identification of dystrophin, the protein product of the Duchenne muscular dystrophy gene, in distinct muscle surface membranes. Int J Mol Med. 2017;40:1078-1088 pubmed publisher
    ..of sarcoglycans, dystroglycans, dystrobrevins and syntrophins, which is closely associated with the membrane cytoskeletal protein dystrophin, represents such a high?molecular?mass protein assembly in skeletal muscles...
  63. Pereza N, PleÅ¡a I, Peterlin A, Jan Å, Tul N, Kapović M, et al. Functional polymorphisms of matrix metalloproteinases 1 and 9 genes in women with spontaneous preterm birth. Dis Markers. 2014;2014:171036 pubmed publisher
    ..association of functional MMP-1-1607 1G/2G and MMP-9-1562 C/T gene polymorphisms with spontaneous preterm birth (SPTB; preterm birth with intact membranes) in European Caucasian women, as well as the contribution of these ..
  64. Li Y, Wang K, Zou Q, Zhou C, Magness R, Zheng J. A possible role of aryl hydrocarbon receptor in spontaneous preterm birth. Med Hypotheses. 2015;84:494-7 pubmed publisher
    ..To date, the etiology of spontaneous PTB (sPTB) remains unclear; however, intrauterine bacterial infection-induced inflammation is considered to be one of the ..
  65. Yang X, Zhang X, Wu Z, Peng W, Zhu L, Wang Y. [A case-control study on association between OAS1 polymorphism and susceptibility to spontaneous preterm birth and preterm premature rupture of membranes]. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17:898-902 pubmed
    ..genetic polymorphism of 2',5'-oligoadenylate synthetase 1 (OAS1) and susceptibility to spontaneous preterm birth (SPTB) and preterm premature rupture of membranes (PPROM)...
  66. Saccone G, Ciardulli A, Xodo S, Dugoff L, Ludmir J, D antonio F, et al. Cervical pessary for preventing preterm birth in twin pregnancies with short cervical length: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2017;30:2918-2925 pubmed publisher
    To evaluate the effectiveness of cervical pessary for preventing spontaneous preterm birth (SPTB) in twin pregnancies with an asymptomatic transvaginal ultrasound cervical length (TVU CL) in the second trimester...
  67. Freitas A, Bocking A, Hill J, Money D. Increased richness and diversity of the vaginal microbiota and spontaneous preterm birth. Microbiome. 2018;6:117 pubmed publisher
    ..in this microbiota have been associated with negative reproductive outcomes, such as spontaneous preterm birth (sPTB), but the mechanisms underlying the association between a disturbed microbiota and sPTB remain poorly understood...
  68. Matsuoka Y, Li X, Bennett V. Adducin: structure, function and regulation. Cell Mol Life Sci. 2000;57:884-95 pubmed
    ..Prominent physiological sites of regulation of adducin include dendritic spines of hippocampal neurons, platelets and growth cones of axons. ..
  69. Tang H, Speicher D. In vivo phosphorylation of human erythrocyte spectrin occurs in a sequential manner. Biochemistry. 2004;43:4251-62 pubmed
  70. Prchal J, Morley B, Yoon S, Coetzer T, Palek J, Conboy J, et al. Isolation and characterization of cDNA clones for human erythrocyte beta-spectrin. Proc Natl Acad Sci U S A. 1987;84:7468-72 pubmed
  71. Roman A, Rochelson B, Fox N, Hoffman M, Berghella V, Patel V, et al. Efficacy of ultrasound-indicated cerclage in twin pregnancies. Am J Obstet Gynecol. 2015;212:788.e1-6 pubmed publisher
    ..Primary outcome was spontaneous PTB (SPTB) <34 weeks. Secondary outcome was SPTB <28, <32, and <37 weeks...
  72. Boelig R, Orzechowski K, Berghella V. Cervical length, risk factors, and delivery outcomes among women with spontaneous preterm birth. J Matern Fetal Neonatal Med. 2016;29:2840-4 pubmed publisher
    To evaluate differences in risk factors and delivery outcomes among women with spontaneous preterm birth (sPTB) with short (≤25 mm) versus normal (>25 mm) cervical length (CL)...
  73. Maillet P, Alloisio N, Morle L, Delaunay J. Spectrin mutations in hereditary elliptocytosis and hereditary spherocytosis. Hum Mutat. 1996;8:97-107 pubmed
    ..In particular, they involve the SPTA1 and SPTB genes that encode erythroid spectrin alpha- and beta-chains, respectively...
  74. Shoeman R, Hartig R, Hauses C, Traub P. Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease. Cell Biol Int. 2002;26:529-39 pubmed
    ..Control experiments demonstrated that the effect and protein cleavages described are due to action of the HIV-1 PR and not to the action of endogenous host cell proteases. ..
  75. Uquillas K, Fox N, Rebarber A, Saltzman D, Klauser C, Roman A. A comparison of cervical length measurement techniques for the prediction of spontaneous preterm birth. J Matern Fetal Neonatal Med. 2017;30:50-53 pubmed
    ..well as two other commonly used techniques of cervical length assessment in predicting spontaneous preterm birth (SPTB). This was a retrospective cohort analysis of singleton gestations with a history of SPTB...
  76. Garbarz M, Tse W, Gallagher P, Picat C, Lecomte M, Galibert F, et al. Spectrin Rouen (beta 220-218), a novel shortened beta-chain variant in a kindred with hereditary elliptocytosis. Characterization of the molecular defect as exon skipping due to a splice site mutation. J Clin Invest. 1991;88:76-81 pubmed
  77. Hadži Lega M, Markova A, Stefanovic M, Tanturovski M. Correlation of cervical length, fetal fibronectin, phIGFBP-1, and cytokines in spontaneous preterm birth up to 14 days from sampling. J Perinat Med. 2015;43:545-51 pubmed publisher
    ..fFN), phIGFBP-1 (actim partus test), cytokines (IL-6, IL-2R, and TNF-α), and spontaneous preterm birth (SPTB) up to 14 days from sampling...
  78. Manuck T, Esplin M, Biggio J, Bukowski R, Parry S, Zhang H, et al. The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool. Am J Obstet Gynecol. 2015;212:487.e1-487.e11 pubmed publisher
    Spontaneous preterm birth (SPTB) is a complex condition that is likely a final common pathway with multiple possible causes...
  79. Kuhrt K, Smout E, Hezelgrave N, Seed P, Carter J, Shennan A. Development and validation of a tool incorporating cervical length and quantitative fetal fibronectin to predict spontaneous preterm birth in asymptomatic high-risk women. Ultrasound Obstet Gynecol. 2016;47:104-9 pubmed publisher
    To develop a predictive tool for spontaneous preterm birth (sPTB) in asymptomatic high-risk women that includes quantification of fetal fibronectin (fFN) along with cervical length (CL) measurement and other clinical factors...
  80. Turitz A, Bastek J, Purisch S, Elovitz M, Levine L. Patient characteristics associated with 17-alpha hydroxyprogesterone caproate use among a high-risk cohort. Am J Obstet Gynecol. 2016;214:536.e1-536.e5 pubmed publisher
    ..Women with a singleton pregnancy were included if they had a prior spontaneous PTB (sPTB). The χ(2) tests were performed for univariate analyses...
  81. Giorgi M, Cianci C, Gallagher P, Morrow J. Spectrin oligomerization is cooperatively coupled to membrane assembly: a linkage targeted by many hereditary hemolytic anemias?. Exp Mol Pathol. 2001;70:215-30 pubmed
    ..Collectively, these results demonstrate a molecular mechanism whereby a membrane receptor can directly promote cytoskeletal assembly. ..
  82. Barner J, Petrilla A, Kang H, Shen X, Alshehri A, Sullivan E, et al. Fetal fibronectin testing and pregnancy outcomes among Texas Medicaid patients at risk for preterm birth. Am J Manag Care. 2017;23:S363-S370 pubmed
    ..of pregnancy in patients with symptomatic preterm labor (PTL) helps assess the risk of spontaneous preterm birth (sPTB), yet the extent of its use is unknown...
  83. Ducarme G, Desroys Du Roure F, Le Thuaut A, Grange J, Vital M, Dimet J. Efficacy of serum procalcitonin to predict spontaneous preterm birth in women with threatened preterm labour: a prospective observational study. BMC Pregnancy Childbirth. 2018;18:65 pubmed publisher
    A hypothesis of preterm parturition is that the pathogenesis of spontaneous preterm birth (sPTB) may be associated with an inflammatory process...
  84. Christensen R, Nussenzveig R, Reading N, Agarwal A, Prchal J, Yaish H. Variations in both ?-spectrin (SPTA1) and ?-spectrin ( SPTB ) in a neonate with prolonged jaundice in a family where nine individuals had hereditary elliptocytosis. Neonatology. 2014;105:1-4 pubmed publisher
    ..In addition, a novel heterozygous mutation was identified in exon 2 of the ?-spectrin gene SPTB. No mutations were identified in ANK1 (ankyrin-1), SLC4A1 (band 3), EPB41 (band 4.1), or EPB42 (band 4.2).
  85. Albayrak E, Dogru H, Ozmen Z, Altunkaş A, Kalayci T, Inci M, et al. Is evaluation of placenta with real-time sonoelastography during the second trimester of pregnancy an effective method for the assessment of spontaneous preterm birth risk?. Clin Imaging. 2016;40:926-30 pubmed publisher
    ..measured by real-time sonoelastography (SE) in the second trimester in the prediction of spontaneous preterm birth (sPTB). This study included 70 pregnant women who applied to our clinic for routine second-trimester screening...
  86. Gray C, McCowan L, Patel R, Taylor R, Vickers M. Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study. Sci Rep. 2017;7:815 pubmed publisher
    ..Although women with a previous spontaneous preterm birth (SPTB) are considered at high risk for recurrence, the majority occur in women without prior history...
  87. Drassinower D, Običan S, Siddiq Z, Heller D, Gyamfi Bannerman C, Friedman A. Does the clinical presentation of a prior preterm birth predict risk in a subsequent pregnancy?. Am J Obstet Gynecol. 2015;213:686.e1-7 pubmed publisher
    ..risk of recurrent preterm birth differs based on the clinical presentation of a prior spontaneous preterm birth (SPTB): advanced cervical dilatation (ACD), preterm premature rupture of membranes (PPROM), or preterm labor (PTL)...
  88. Saccone G, Ciardulli A, Xodo S, Dugoff L, Ludmir J, Pagani G, et al. Cervical Pessary for Preventing Preterm Birth in Singleton Pregnancies With Short Cervical Length: A Systematic Review and Meta-analysis. J Ultrasound Med. 2017;36:1535-1543 pubmed publisher
    To evaluate the effectiveness of cervical pessary for preventing spontaneous preterm birth (SPTB) in singleton gestations with a second trimester short cervix. Electronic databases were searched from their inception until February 2016...
  89. Javorski N, Lima C, Silva L, Crovella S, de Azevedo Silva J. Vitamin D receptor (VDR) polymorphisms are associated to spontaneous preterm birth and maternal aspects. Gene. 2018;642:58-63 pubmed publisher
    ..and Cdx-2 (rs11568820 T>C), within VDR, using TaqMan fluorogenic probes, and differential susceptibility to SPTB. We assessed 104 pregnant women with SPTB and 85 women with normal birth in a Northeastern Brazilian population...
  90. Pothier B, Morle L, Alloisio N, Ducluzeau M, Caldani C, Feo C, et al. Spectrin Nice (beta 220/216): a shortened beta-chain variant associated with an increase of the alpha I/74 fragment in a case of elliptocytosis. Blood. 1987;69:1759-65 pubmed
    ..In the present case, we consider that the abnormality is a consequence of the beta-chain alteration. The parents seemed asymptomatic. As a result, we regard this new spectrin variant as deriving from a de novo mutation. ..
  91. Lu C, Fu W, Xu X, Mattson M. Numb-mediated neurite outgrowth is isoform-dependent, and requires activation of voltage-dependent calcium channels. Neuroscience. 2009;161:403-12 pubmed publisher
    ..Here we report that the neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) ..
  92. Orzechowski K, Boelig R, Nicholas S, Baxter J, Berghella V. Is universal cervical length screening indicated in women with prior term birth?. Am J Obstet Gynecol. 2015;212:234.e1-5 pubmed publisher
    ..gestations between 18 0/7-23 6/7 weeks undergoing TVU CL screening for prediction of spontaneous preterm birth (sPTB). Women with a prior sPTB, with cerclage, and without delivery data available were excluded...