SPRR2D

Summary

Gene Symbol: SPRR2D
Description: small proline-rich protein 2D
Alias: SPR-2D, SPR-II, small proline-rich protein II
Species: human

Top Publications

  1. pmc Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence
    Natalie Gleyzer
    Department of Cell and Molecular Biology, Northwestern Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 288:8004-15. 2013
  2. ncbi Gene expression pattern and hormonal regulation of small proline-rich protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy
    Yin Fei Tan
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Reprod Nutr Dev 46:641-55. 2006
  3. doi Glucocorticoid receptor regulates overlapping and differential gene subsets in developing and adult skin
    Lisa M Sevilla
    Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Cientificas, Jaime Roig 11, E 46010 Valencia, Spain
    Mol Endocrinol 24:2166-78. 2010
  4. pmc New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation
    Gerrit J Bouma
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Biol Reprod 82:380-9. 2010
  5. pmc Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern
    Hyunjoo J Lee
    Department of Medicine, Genetics Program, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Dev Dyn 238:812-25. 2009
  6. doi Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families
    Kati Kainu
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Exp Dermatol 18:109-15. 2009
  7. pmc Expression and regulation of cornified envelope proteins in human corneal epithelium
    Louis Tong
    Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 47:1938-46. 2006
  8. ncbi Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus
    Seok Ho Hong
    Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 133 791, Korea
    Mol Cells 17:477-84. 2004
  9. ncbi Differential expression of cornified cell envelope precursors in normal skin, intraorally transplanted skin and normal oral mucosa
    F Katou
    Department of Maxillofacial Surgery, Tohoku University Schools of Dentistry and Medicine 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Br J Dermatol 148:898-905. 2003
  10. ncbi Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function
    A Cabral
    Department of Molecular Genetics, Leiden Institute of Chemistry, P O Box 9502, 2300 RA Leiden, The Netherlands
    J Biol Chem 276:19231-7. 2001

Research Grants

Scientific Experts

  • F Katou
  • Gerrit J Bouma
  • SERGEI TEVOSIAN
  • Sergei G Tevosian
  • Natalie Gleyzer
  • Lisa M Sevilla
  • Kati Kainu
  • Hyunjoo J Lee
  • Yin Fei Tan
  • Louis Tong
  • Seok Ho Hong
  • Richard C Scarpulla
  • A Cabral
  • Ana Sanchis
  • Pilar Bayo
  • Víctor Latorre
  • Paloma Perez
  • Juha Kere
  • Lionel Fry
  • Stephanie M Correa
  • Barbara S Baker
  • Annica Inerot
  • Katja Kivinen
  • Ulpu Saarialho-Kere
  • Kenneth H Albrecht
  • Anne V Powles
  • Marco Zucchelli
  • Ravi S Kahlon
  • Sari Suomela
  • Dorothy E Pazin
  • Lena Samuelsson
  • H J Song
  • Roger Beuerman
  • Stephen C Pflugfelder
  • Arturo L Villarreal
  • Xiao yang Sun
  • Shuang Tang
  • Yun shang Piao
  • Fei Xue Li
  • Cintia S de Paiva
  • Zhuo Chen
  • Yan Ling Wang
  • Rosa M Corrales
  • De Quan Li
  • Moon Kyoo Kim
  • C Backendorf
  • Chung Hoon Kim
  • Young Jin Lee
  • Myung Chan Gye
  • Ji Won Lee
  • Byung Moon Kang
  • Hee Young Nah
  • Ji Yoon Lee
  • D Nizetic
  • A South
  • T Kartasova
  • P Voskamp
  • A M Cleton-Jansen
  • N Darwiche
  • U Lichti
  • T Kuroki
  • P M Steinert
  • G Poy
  • S Gibbs
  • P van de Putte
  • R Fijneman
  • A G van Kessel
  • J Wiegant

Detail Information

Publications13

  1. pmc Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence
    Natalie Gleyzer
    Department of Cell and Molecular Biology, Northwestern Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 288:8004-15. 2013
    ..Both PRC and its targets (IL1α, SPRR2D, and SPRR2F) were rapidly induced by menadione, an agent that promotes apoptosis through the generation of ..
  2. ncbi Gene expression pattern and hormonal regulation of small proline-rich protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy
    Yin Fei Tan
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Reprod Nutr Dev 46:641-55. 2006
    ..that the transcripts of sprr2b, 2e and 2g genes were up-regulated in the proestrous and estrous uteri, and sprr2d was up-regulated only in the estrous uterus...
  3. doi Glucocorticoid receptor regulates overlapping and differential gene subsets in developing and adult skin
    Lisa M Sevilla
    Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Cientificas, Jaime Roig 11, E 46010 Valencia, Spain
    Mol Endocrinol 24:2166-78. 2010
    ..Whereas Krt77 and Elf5 expression remained unaffected by loss of GR in adult epidermis, Fkbp51, Sprr2d, and Defb1 were strongly repressed...
  4. pmc New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation
    Gerrit J Bouma
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Biol Reprod 82:380-9. 2010
    ..in a sexually dimorphic pattern, and whole-mount in situ hybridization analysis verified 4930563E18Rik, Pld1, and Sprr2d are expressed in XX gonads, and Fbln2, Ppargc1a, and Scrn1 are expressed in XY gonads...
  5. pmc Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern
    Hyunjoo J Lee
    Department of Medicine, Genetics Program, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Dev Dyn 238:812-25. 2009
    ..We identified two novel SCP markers, 1700106J16Rik and Sprr2d, whose expression is ovary-biased during early gonad development, and altered in Wnt4, Sf1, Wt1, and Fog2 mutant ..
  6. doi Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families
    Kati Kainu
    Department of Medical Genetics, University of Helsinki, Helsinki, Finland
    Exp Dermatol 18:109-15. 2009
    ..The families supported association to the two gene regions, but there was also evidence of allelic heterogeneity...
  7. pmc Expression and regulation of cornified envelope proteins in human corneal epithelium
    Louis Tong
    Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 47:1938-46. 2006
    ....
  8. ncbi Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus
    Seok Ho Hong
    Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 133 791, Korea
    Mol Cells 17:477-84. 2004
    ..In addition, they suggest that some members of the family play an important role in uterine processes such as the estrous cycle, early pregnancy and implantation...
  9. ncbi Differential expression of cornified cell envelope precursors in normal skin, intraorally transplanted skin and normal oral mucosa
    F Katou
    Department of Maxillofacial Surgery, Tohoku University Schools of Dentistry and Medicine 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Br J Dermatol 148:898-905. 2003
    ..Skin flaps have routinely been used as substitutes for oral mucosa after extensive resection of oral tissues. However, it remains unknown how the transplanted skin flaps perform as a host defence in the new environment of the oral cavity...
  10. ncbi Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function
    A Cabral
    Department of Molecular Genetics, Leiden Institute of Chemistry, P O Box 9502, 2300 RA Leiden, The Netherlands
    J Biol Chem 276:19231-7. 2001
    ..Differential regulation of highly homologous genes underlines the importance of SPRR protein dosage in providing optimal barrier function to different epithelia, while allowing adaptation to diverse external insults...
  11. ncbi Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues
    H J Song
    National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Genomics 55:28-42. 1999
    ..The correlation between the physical location of the genes in the Sprr2 locus and their expression patterns suggests multiple levels of controlled expression...
  12. ncbi Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins
    S Gibbs
    Department of Molecular Genetics, University of Leiden, The Netherlands
    Genomics 16:630-7. 1993
    ..We propose that a process of homogenization has acted on the different members of one subfamily, whereas the different subfamilies appear to have diverged from each other, at the levels of both protein structure and gene regulation...
  13. pmc Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes
    T Kartasova
    Laboratory of Molecular Genetics, State University of Leiden, The Netherlands
    Mol Cell Biol 8:2195-203. 1988
    ..The level of mRNAs corresponding to the two groups of cDNAs is increased in the cytoplasm of human epidermal keratinocytes after both UV irradiation and treatment with 4-nitroquinoline 1-oxide or 12-O-tetradecanoylphorbol 13-acetate...

Research Grants3

  1. Transcriptional Control of Mammalian Sexual Development
    SERGEI TEVOSIAN; Fiscal Year: 2009
    ..g., Sp5, Sprr2d, Irx3 and Gng13) have been recently identified as sexually dimorphic by us and others...
  2. Transcriptional Control of Mammalian Sexual Development
    Sergei G Tevosian; Fiscal Year: 2010
    ..g., Sp5, Sprr2d, Irx3 and Gng13) have been recently identified as sexually dimorphic by us and others...
  3. Somatic support cell function in gonad development
    GERRIT BOUMA; Fiscal Year: 2006
    ..The proposed experiments will identify genes expressed in gonadal SSCs that play a role in gonadal XY sex reversal. ..