spermidine spermine N1 acetyltransferase

Summary

Gene Symbol: spermidine spermine N1 acetyltransferase
Description: spermidine/spermine N1-acetyltransferase 1
Alias: DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1, diamine acetyltransferase 1, diamine N-acetyltransferase 1, polyamine N-acetyltransferase 1, putrescine acetyltransferase, spermidine/spermine N1-acetyltransferase alpha
Species: human

Top Publications

  1. Coleman C, Pegg A. Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation. Biochem J. 2001;358:137-45 pubmed
    Spermidine/spermine N(1)-acetyltransferase (SSAT), a key enzyme in mammalian polyamine catabolism, undergoes rapid turnover (half-life approx...
  2. Guipponi M, Deutsch S, Kohler K, Perroud N, Le Gal F, Vessaz M, et al. Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:799-807 pubmed publisher
    It has recently been proposed that the SSAT gene plays a role in the predisposition to suicidal behavior. SSAT expression was found to be down-regulated in the brain of suicide completers...
  3. Klempan T, Rujescu D, Mérette C, Himmelman C, Sequeira A, Canetti L, et al. Profiling brain expression of the spermidine/spermine N1-acetyltransferase 1 (SAT1) gene in suicide. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:934-43 pubmed publisher
  4. Casero R, Celano P, Ervin S, Applegren N, Wiest L, Pegg A. Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase. J Biol Chem. 1991;266:810-4 pubmed
    ..The unusually high expression of Spd/Spm acetyltransferase mRNA by the NCI H157 cells in response to treatment does not appear to be a result of an amplification of the Spd/Spm acetyltransferase gene. ..
  5. Coleman C, Huang H, Pegg A. Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase. Biochem J. 1996;316 ( Pt 3):697-701 pubmed
    Spermidine/spermine-N1-acetyltransferase (SSAT) is a key enzyme in the degradation of polyamines. Alanine-scanning mutagenesis of all eight arginine residues was used to investigate the arginine residues involved in acetyl-CoA binding...
  6. Wang Z, Zahedi K, Barone S, Tehrani K, Rabb H, Matlin K, et al. Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury. J Am Soc Nephrol. 2004;15:1844-52 pubmed
    To ascertain the role of spermidine/spermine N-1-acetyl-transferase (SSAT; the rate-limiting enzyme in polyamine catabolism) in cell injury, cultured kidney (HEK 293) cells conditionally overexpressing SSAT were generated...
  7. Chen C, Young B, Coleman C, Pegg A, Sheppard D. Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration. J Cell Biol. 2004;167:161-70 pubmed
    ..two-hybrid screening, we identified the polyamine catabolizing enzyme spermidine/spermine N(1)-acetyltransferase (SSAT) as a specific binding partner of the alpha9 cytoplasmic domain...
  8. Sequeira A, Gwadry F, Ffrench Mullen J, Canetti L, Gingras Y, Casero R, et al. Implication of SSAT by gene expression and genetic variation in suicide and major depression. Arch Gen Psychiatry. 2006;63:35-48 pubmed
    ..3 in either direction [P<or=.01] in at least 2 regions). The spermine/spermidine N(1)-acetyltransferase gene (SSAT) was successfully validated by reverse transcription-polymerase chain reaction, immunohistochemistry, and Western ..
  9. Vaquero Lorenzo C, Riaza Bermudo Soriano C, Perez Rodriguez M, Diaz Hernandez M, Lopez Castroman J, Fernandez Piqueras J, et al. Positive association between SAT-1 -1415T/C polymorphism and anxiety. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:515-9 pubmed publisher
    ..Spermidine/spermine N1-acetyltransferase (SSAT-1) is the main enzyme regulating polyamine catabolism...

More Information

Publications122 found, 100 shown here

  1. Bermudo Soriano C, Vaquero Lorenzo C, Diaz Hernandez M, Perez Rodriguez M, Fernandez Piqueras J, Saiz Ruiz J, et al. SAT-1 -1415T/C polymorphism and susceptibility to schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:345-8 pubmed publisher
    ..Spermidine/spermine N1-acetyltransferase (SSAT-1) and its coding gene (SAT-1) are the main factors regulating polyamine catabolism...
  2. Babbar N, Ignatenko N, Casero R, Gerner E. Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. J Biol Chem. 2003;278:47762-75 pubmed
    ..Spermidine/sperm-ine N1-acetyltransferase (SSAT) gene, which encodes a polyamine catabolic enzyme, was induced by clinically relevant sulindac sulfone ..
  3. Pledgie A, Huang Y, Hacker A, Zhang Z, Woster P, Davidson N, et al. Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines. J Biol Chem. 2005;280:39843-51 pubmed
    ..The original hypothesis was that analogue induction of the rate-limiting spermidine/spermine N1-acetyltransferase (SSAT) provided substrate for the peroxisomal acetylpolyamine oxidase (PAO), resulting in a decrease in polyamine pools ..
  4. Fiori L, Mechawar N, Turecki G. Identification and characterization of spermidine/spermine N1-acetyltransferase promoter variants in suicide completers. Biol Psychiatry. 2009;66:460-7 pubmed publisher
    ..Our results indicate that genetic variations in the promoter region of SAT1 are involved in determining levels of gene expression and might provide a mechanism for the decreased SAT1 expression observed in suicide completers. ..
  5. Casero R, Celano P, Ervin S, Wiest L, Pegg A. High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma. Biochem J. 1990;270:615-20 pubmed
    ..BESpm) is preceded by an extremely high induction of spermidine/spermine N1-acetyltransferase (SSAT)...
  6. Zahedi K, Bissler J, Wang Z, Josyula A, Lu L, Diegelman P, et al. Spermidine/spermine N1-acetyltransferase overexpression in kidney epithelial cells disrupts polyamine homeostasis, leads to DNA damage, and causes G2 arrest. Am J Physiol Cell Physiol. 2007;292:C1204-15 pubmed
    Expression of spermidine/spermine N(1)-acetyltransferase (SSAT) increases in kidneys subjected to ischemia-reperfusion injury (IRI)...
  7. Fiori L, Turecki G. Association of the SAT1 in/del polymorphism with suicide completion. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:825-9 pubmed publisher
    ..These results add support for a role of SAT1 in conferring a risk for suicide completion, in particular in the context of depressive disorders. ..
  8. Kraus D, Yang Q, Kong D, Banks A, Zhang L, Rodgers J, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508:258-62 pubmed publisher
    ..by the rate-limiting enzymes ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT; encoded by Sat1) and by polyamine oxidase (PAO), and has a major role in energy metabolism...
  9. Arisan E, Obakan P, Coker Gurkan A, Calcabrini A, Agostinelli E, Unsal N. CDK inhibitors induce mitochondria-mediated apoptosis through the activation of polyamine catabolic pathway in LNCaP, DU145 and PC3 prostate cancer cells. Curr Pharm Des. 2014;20:180-8 pubmed
    ..Similarly to classical chemotherapeutic agents, both drugs could up-regulate polyamine catabolic enzymes (SSAT, SMO and PAO) in cell type dependent manner...
  10. Smirnova O, Keinänen T, Ivanova O, Hyvonen M, Khomutov A, Kochetkov S, et al. Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism. Biochem Biophys Res Commun. 2017;483:904-909 pubmed publisher
    ..and degradation, respectively, ornithine decarboxylase (ODC) and spermidine/spermine-N1-acetyl transferase (SSAT), increases transiently...
  11. Forte A, Grossi M, Bancone C, Cipollaro M, De Feo M, Hellstrand P, et al. Polyamine concentration is increased in thoracic ascending aorta of patients with bicuspid aortic valve. Heart Vessels. 2018;33:327-339 pubmed publisher
    ..In conclusion, BAV, but not TAV non-dilated samples show increased polyamine concentration, accompanied by the activation of a regulatory negative feedback mechanism. ..
  12. Litvinova L, Zatolokin P, Vulf M, Mazunin I, Skuratovskaia D. The relationship between the mtDNA copy number in insulin-dependent tissues and markers of endothelial dysfunction and inflammation in obese patients. BMC Med Genomics. 2019;12:41 pubmed publisher
    ..relationship of the copy number of mtDNA in adipose tissue from different locations (subcutaneous adipose tissue (SAT), mesentery (Mes), greater omentum (GO)), liver biopsy samples and mononuclear blood cells (MNCs) with endothelial ..
  13. Lin Y, Zhang X, Wang L, Zhao Y, Li H, Xiao W, et al. Polyamine depletion attenuates isoproterenol-induced hypertrophy and endoplasmic reticulum stress in cardiomyocytes. Cell Physiol Biochem. 2014;34:1455-65 pubmed publisher
    ..Expression of ornithine decarboxylase (ODC) and spermidine/spermine N1-acetyltransferase (SSAT) were analyzed via real-time PCR and Western blotting...
  14. Lin Y, Zhang X, Xiao W, Li B, Wang J, Jin L, et al. Endoplasmic Reticulum Stress is Involved in DFMO Attenuating Isoproterenol-Induced Cardiac Hypertrophy in Rats. Cell Physiol Biochem. 2016;38:1553-62 pubmed publisher
    ..Expression of ODC and spermidine/spermine N1-acetyltransferase (SSAT) were analyzed via real-time PCR and Western blot analysis...
  15. Copur Çiçek A, Sandalli C, Budak E, Yagmur G, Cizmeci Z, Ak S, et al. [Characterization of class 1 and class 2 integron gene cassettes in Escherichia coli strains isolated from urine cultures: a multicenter study]. Mikrobiyol Bul. 2016;50:175-85 pubmed
    ..aadA1 gene was detected in four isolates. dfrA17-sat-aadA5 co-existence was detected among class 2 integron gene cassette in isolates from six provinces...
  16. Awad A, Kamel R, Sherief M. Effect of thymoquinone on hepatorenal dysfunction and alteration of CYP3A1 and spermidine/spermine N-1-acetyl-transferase gene expression induced by renal ischaemia-reperfusion in rats. J Pharm Pharmacol. 2011;63:1037-42 pubmed publisher
    ..I/R caused induction of mRNA expression of spermidine/spermine N-1-acetyl-transferase (SSAT), a catabolic enzyme that participates in polyamine metabolism, in liver and kidney tissues...
  17. Khadir A, Kavalakatt S, Abubaker J, Cherian P, Madhu D, Al Khairi I, et al. Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone. Metabolism. 2016;65:1409-20 pubmed publisher
    ..Subcutaneous adipose tissue (SAT) and blood samples were collected from non-diabetic adult human lean (n=40) and obese (n=40, at baseline and after ..
  18. Antunes B, Monteiro P, Silveira L, Brunholi C, Lira F, Freitas Júnior I. MACRONUTRIENT INTAKE IS CORRELATED WITH DYSLIPIDEMIA AND LOW-GRADE INFLAMMATION IN CHILDHOOD OBESITY BUT MOSTLY IN MALE OBESE. Nutr Hosp. 2015;32:997-1003 pubmed publisher
    ..X-ray absorptiometry (DEXA) and measures of intra-abdominal adiposity (IAAT) and subcutaneous adiposity tissue (SAT) were done by ultrasound...
  19. Vitello E, Quek S, Kincaid H, Fuchs T, Crichton D, Troisch P, et al. Cancer-secreted AGR2 induces programmed cell death in normal cells. Oncotarget. 2016;7:49425-49434 pubmed publisher
    ..SAT1 encodes spermidine/spermine N1-acetyltransferase, which maintains intracellular polyamine levels. Abnormal polyamine metabolism as a result of altered SAT1 activity has an adverse effect on cells through the induction of PCD. ..
  20. Uchiyama T, Tomono S, Sato K, Nakamura T, Kurabayashi M, Okajima F. Angiotensin II Reduces Lipoprotein Lipase Expression in Visceral Adipose Tissue via Phospholipase C β4 Depending on Feeding but Increases Lipoprotein Lipase Expression in Subcutaneous Adipose Tissue via c-Src. PLoS ONE. 2015;10:e0139638 pubmed publisher
    ..Adipose tissues were divided into visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) for comparison. AngII accelerated LPL expression in SAT but, on the contrary, suppressed its expression in VAT...
  21. Geisler C, Schweitzer L, Muller M. Functional correlates of detailed body composition in healthy elderly subjects. J Appl Physiol (1985). 2017;:jap.00162.2017 pubmed publisher
    ..57) and kidneys with GFR (r= 0.57). While VAT correlated to HOMA (r= 0.59), subcutaneous adipose tissue (SAT) was related to plasma leptin levels (r= 0.84)...
  22. Du Plessis J, van Pelt J, Korf H, Mathieu C, Van Der Schueren B, Lannoo M, et al. Association of Adipose Tissue Inflammation With Histologic Severity of Nonalcoholic Fatty Liver Disease. Gastroenterology. 2015;149:635-48.e14 pubmed publisher
    ..We analyzed the transcriptional profiles of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT), and phenotypes and functional characteristics of adipocyte tissue macrophages (..
  23. Çoker Gürkan A, Arisan E, Obakan P, Palavan Unsal N. Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells. Amino Acids. 2015;47:87-100 pubmed publisher
    ..The resistant profile caused by p53 defect also caused a cell type-specific response to PA pool depletion and SSAT overexpression...
  24. Simeone P, Liani R, Tripaldi R, Di Castelnuovo A, Guagnano M, Tartaro A, et al. Thromboxane-Dependent Platelet Activation in Obese Subjects with Prediabetes or Early Type 2 Diabetes: Effects of Liraglutide- or Lifestyle Changes-Induced Weight Loss. Nutrients. 2018;10: pubmed publisher
    ..until achieving a comparable weight loss (-7% of initial body weight), to assess whether changes in subcutaneous (SAT) and visceral (VAT) adipose tissue distribution (MRI), insulin sensitivity (Matsuda Index) and beta-cell ..
  25. Yang X, Zou W, Zeng J, Xie S, An T, Luo X, et al. Prevalence of antimicrobial resistance and integron gene cassettes in Escherichia coli isolated from yaks (Poephagus grunniens) in Aba Tibetan Autonomous Prefecture, China. Microb Pathog. 2017;111:274-279 pubmed publisher
    ..It is therefore urgently necessary to begin continuous surveillance and analysis of antibiotic resistance and integron cassettes in other bacteria from yaks. ..
  26. Thomas T, Thomas T. Cellular and Animal Model Studies on the Growth Inhibitory Effects of Polyamine Analogues on Breast Cancer. Med Sci (Basel). 2018;6: pubmed publisher
    ..compounds, whereas the activity of the catabolizing enzyme, spermidine/spermine N¹-acetyl transferase (SSAT) was increased by 6-fold by bis(ethyl)norspermine in MCF-7 cells...
  27. Lane D, Bae D, Siafakas A, Suryo Rahmanto Y, Al Akra L, Jansson P, et al. Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes. Biochim Biophys Acta Mol Basis Dis. 2018;1864:2793-2813 pubmed publisher
    ..Collectively, iron and polyamine metabolism are intimately coupled, which has significant ramifications for understanding the integrated role of iron and polyamine metabolism in proliferation. ..
  28. Wallace P, Masbou A, Petersen S, Cheung S. The effects of cranial cooling during recovery on subsequent uncompensable heat stress tolerance. Appl Physiol Nutr Metab. 2015;40:811-6 pubmed publisher
    ..6 km · h(-1), 4% incline) in 35 °C and 60% relative humidity. During a 20-min recovery (rest), participants sat and removed gloves, helmets, and flash hoods but otherwise remained encapsulated...
  29. Bando S, Fukuda D, Soeki T, Nishimoto S, Uematsu E, Matsuura T, et al. Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis. Atherosclerosis. 2015;242:407-14 pubmed publisher
    ..Here, we investigated the link between NLRP3 expression in subcutaneous adipose tissue (SAT) and the severity of coronary atherosclerosis...
  30. Harmens H, Hayes F, Sharps K, Mills G, Calatayud V. Leaf traits and photosynthetic responses of Betula pendula saplings to a range of ground-level ozone concentrations at a range of nitrogen loads. J Plant Physiol. 2017;211:42-52 pubmed publisher
    ..Whilst elevated O3 reduced the light-saturated rate of photosynthesis (Asat) in aging leaves, it did not affect stomatal conductance (gs)...
  31. Tsiotra P, Halvatsiotis P, Patsouras K, Maratou E, Salamalekis G, Raptis S, et al. Circulating adipokines and mRNA expression in adipose tissue and the placenta in women with gestational diabetes mellitus. Peptides. 2018;101:157-166 pubmed publisher
    ..Chemerin mRNA expression in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) was significantly higher compared to placenta in all women (6-to 24-times, p &..
  32. Dallos R, Lakus K, Cahart M, McKenzie R. Becoming invisible: The effect of triangulation on children's well-being. Clin Child Psychol Psychiatry. 2016;21:461-76 pubmed publisher
    ..of triangulation were explored by comparing their responses to pictures from the Separation Anxiety Test (SAT) and a set of pictures designed for the study depicting a variety of triangulation conflicts in families...
  33. Ikenaga M, Yamada Y, Kose Y, Morimura K, Higaki Y, Kiyonaga A, et al. Effects of a 12-week, short-interval, intermittent, low-intensity, slow-jogging program on skeletal muscle, fat infiltration, and fitness in older adults: randomized controlled trial. Eur J Appl Physiol. 2017;117:7-15 pubmed publisher
    ..Subcutaneous (SAT) and intermuscular (IMAT) adipose tissue and muscle cross-sectional area (CSA) were measured at the mid-thigh using ..
  34. Alman A, Smith S, Eckel R, Hokanson J, Burkhardt B, Sudini P, et al. The ratio of pericardial to subcutaneous adipose tissues is associated with insulin resistance. Obesity (Silver Spring). 2017;25:1284-1291 pubmed publisher
    To examine the association between pericardial adipose tissue (PAT) and the ratio of PAT to subcutaneous adipose tissue (SAT) with insulin resistance in adults with and without type 1 diabetes (T1D).
  35. Niculescu A, Le Niculescu H, Levey D, Phalen P, Dainton H, ROSEBERRY K, et al. Precision medicine for suicidality: from universality to subtypes and personalization. Mol Psychiatry. 2017;22:1250-1273 pubmed publisher
  36. Yoshimura A, Goodson C, Johns J, Towe M, Irvine E, Rendradjaja N, et al. Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium. Sci Rep. 2017;7:9258 pubmed publisher
    ..The [oxy-Hb] change during the sustained attention task (SAT) was elevated in patients with ESLD compared to HC in the prefrontal and left temporal regions...
  37. Fukata K, Amimoto K, Fujino Y, Inoue M, Inoue M, Takahashi Y, et al. The effects of aging on the subjective vertical in the frontal plane in healthy adults. J Phys Ther Sci. 2017;29:1950-1953 pubmed publisher
    ..For the subjective postural vertical-eyes open (SPV-EO) and subjective postural vertical (SPV), subjects sat in a seating device that was tilted right or left. The subjects gave a signal when they perceived true verticality...
  38. Li H, Wu G, Fang Q, Zhang M, Hui X, Sheng B, et al. Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat. Nat Commun. 2018;9:272 pubmed publisher
    ..that FGF21 improves systemic insulin sensitivity by promoting the healthy expansion of subcutaneous adipose tissue (SAT). Serum FGF21 levels positively correlate with the SAT area in insulin-sensitive obese individuals...
  39. Lian Y, Fang M, Chen L. Constructing protein-protein interaction network of hypertension with blood stasis syndrome via digital gene expression sequencing and database mining. J Integr Med. 2014;12:476-82 pubmed publisher
    ..Compared with previous methodologies reported in the literature, the present DGE analysis and data mining method have shown a great improvement in analyzing BSS. ..
  40. González Plaza J, Gutiérrez Repiso C, García Serrano S, Rodriguez Pacheco F, Garrido Sánchez L, Santiago Fernández C, et al. Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue. Surg Obes Relat Dis. 2016;12:257-63 pubmed publisher
    The changes in the transcriptomic profiling of subcutaneous adipose tissue (SAT) when weight loss stabilizes after a Roux-en-Y gastric bypass (RYGB) are still largely unknown...
  41. Hjort L, Jørgensen S, Gillberg L, Hall E, Brøns C, Frystyk J, et al. 36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner. Clin Epigenetics. 2017;9:40 pubmed publisher
    ..i>LEP) and adiponectin (ADIPOQ) DNA methylation and gene expression in subcutaneous adipose tissue (SAT) from subjects with LBW and NBW...
  42. Ackerley R, Aimonetti J, Ribot Ciscar E. Emotions alter muscle proprioceptive coding of movements in humans. Sci Rep. 2017;7:8465 pubmed publisher
    ..of participants, while they listened to evocative classical music to induce sad, neutral, or happy emotions, or sat passively (no music)...
  43. Rier H, Jager A, Sleijfer S, van Rosmalen J, Kock M, Levin M. Changes in body composition and muscle attenuation during taxane-based chemotherapy in patients with metastatic breast cancer. Breast Cancer Res Treat. 2018;168:95-105 pubmed publisher
    ..The lumbar skeletal muscle index (LSMI) was used as marker of muscle mass. LSMI, MA, subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT) and intramuscular adipose tissue (IMAT) were measured before and after first-line ..
  44. Vester M, Bilo R, Nijs H, van Rijn R. Pediatric constrictive asphyxia a rare form of child abuse: A report of two cases. Forensic Sci Int. 2018;285:e17-e20 pubmed publisher
    ..In order to stop his daughter from crying, the father admitted that he sometimes sat on his baby while she was lying on the bed...
  45. Xiao L, Casero R. Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells. Biochem J. 1996;313 ( Pt 2):691-6 pubmed
    The expression of spermidine/spermine N1-acetyltransferase (SSAT), the rate-limiting enzyme in the catabolism of polyamines, is highly regulated by a number of factors including the natural polyamines and their analogues...
  46. Paniagua J, Escandell Morales J, Gil Contreras D, Berral de la Rosa F, Romero Jiménez M, Gómez Urbano A, et al. Central obesity and altered peripheral adipose tissue gene expression characterize the NAFLD patient with insulin resistance: Role of nutrition and insulin challenge. Nutrition. 2014;30:177-85 pubmed publisher
    ..patients (n = 9), in the fasted state, after specific test meals (monounsaturated fatty acid [MUFA], saturated fat [SAT], and carbohydrate-rich) and after being challenged with insulin...
  47. Fosshaug L, Dahl C, Risnes I, Bohov P, Berge R, Nymo S, et al. Altered Levels of Fatty Acids and Inflammatory and Metabolic Mediators in Epicardial Adipose Tissue in Patients With Systolic Heart Failure. J Card Fail. 2015;21:916-23 pubmed publisher
    ..tissue in heart failure (HF), and the aim of this study was to investigate epicardial (EAT) and subcutaneous (SAT) adipose tissue in HF patients...
  48. Moreno Navarrete J, Moreno M, Ortega F, Sabater M, Xifra G, Ricart W, et al. CISD1 in association with obesity-associated dysfunctional adipogenesis in human visceral adipose tissue. Obesity (Silver Spring). 2016;24:139-47 pubmed publisher
    ..Subcutaneous (SAT) and visceral (VAT) adipose tissue CISD1 gene expression (real-time PCR) and protein (Western blot) levels were ..
  49. Masterson T, Kirwan C, Davidson L, Larson M, Keller K, Fearnbach S, et al. Brain reactivity to visual food stimuli after moderate-intensity exercise in children. Brain Imaging Behav. 2018;12:1032-1041 pubmed publisher
    ..During the sedentary session, participants sat continuously for 30 min...
  50. Tint M, Chong M, Aris I, Godfrey K, Quah P, Kapur J, et al. Association between maternal mid-gestation vitamin D status and neonatal abdominal adiposity. Int J Obes (Lond). 2018;42:1296-1305 pubmed publisher
    ..0 nmol/L) and sufficient (>75.0 nmol/L) groups. Neonatal AAT was classified into superficial (sSAT), deep subcutaneous (dSAT), and internal (IAT) adipose tissue compartments...
  51. Bewley M, Graziano V, Jiang J, Matz E, Studier F, Pegg A, et al. Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Proc Natl Acad Sci U S A. 2006;103:2063-8 pubmed
    Spermidine/spermine N1-acetyltransferase (SSAT) is a key enzyme in the control of polyamine levels in human cells, as acetylation of spermidine and spermine triggers export or degradation...
  52. Ivanov I, Atkins J, Michael A. A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation. Nucleic Acids Res. 2010;38:353-9 pubmed publisher
    ..The uORF-mediated polyamine responsive autoregulatory circuits found in polyamine pathway mRNAs exemplify the translationally regulated dynamic interface between components of the proteome and metabolism. ..
  53. Takimoto Y, Imai T, Okumura T, Takeda N, Inohara H. Three-dimensional analysis of otolith-ocular reflex during eccentric rotation in humans. Neurosci Res. 2016;111:34-40 pubmed publisher
    ..1, 0.3, 0.5, and 0.7Hz. The radius of rotation during ER was 90cm. The participants sat on a chair at three different positions: on the axis (center rotation, CR), at 90cm backward from the axis (nose-in ..
  54. Zhang J, Wang Y, Cheng R, Ni C, Liang J, Li M, et al. Novel MBTPS2 missense mutation causes a keratosis follicularis spinulosa decalvans phenotype: mutation update and review of the literature. Clin Exp Dermatol. 2016;41:757-60 pubmed publisher
    Keratosis follicularis spinulosa decalvans (KFSD) is an X-linked condition characterized by keratotic follicular papules and progressive alopecia, which is caused by mutations in the MBTPS2 gene...
  55. Mukherjee A, Kundu M, Basu B, Sinha B, Chatterjee M, Bairagya M, et al. Arsenic load in rice ecosystem and its mitigation through deficit irrigation. J Environ Manage. 2017;197:89-95 pubmed publisher
    ..arsenic load in rice ecosystem under deficit irrigation practices like intermittent ponding (IP), saturation (SAT) and aerobic (AER) imposed during stress allowable stage (16-40 days after transplanting) of the crop (genotype ..
  56. Bordin L, Vargiu C, Clari G, Brunati A, Colombatto S, Salvi M, et al. Phosphorylation of recombinant human spermidine/spermine N(1)-acetyltransferase by CK1 and modulation of its binding to mitochondria: a comparison with CK2. Biochem Biophys Res Commun. 2002;290:463-8 pubmed
    Cytosolic spermidine/spermine acetyltransferase (SSAT) catalyzes the acetylation of the N(1)-propylamino groups of spermine and spermidine. The enzyme has a very short half-life and is rapidly induced by various stimuli...
  57. Vaittinen M, Walle P, Kuosmanen E, Männistö V, Käkelä P, Ågren J, et al. FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue. J Lipid Res. 2016;57:56-65 pubmed publisher
    ..Variation in the FADS1/2 genes associated with IL-1β and NFκB pathway gene expression in SAT after weight reduction, but not at baseline...
  58. Moreno Castellanos N, Guzmán Ruiz R, Cano D, Madrazo Atutxa A, Peinado J, Pereira Cunill J, et al. The Effects of Bariatric Surgery-Induced Weight Loss on Adipose Tissue in Morbidly Obese Women Depends on the Initial Metabolic Status. Obes Surg. 2016;26:1757-67 pubmed publisher
    ..Abdominal subcutaneous adipose tissue (SAT) samples were obtained from morbidly obese women (n = 18) before and 13.3 ± 0...
  59. Wang M, Xie W, Li A, Xu S. Structural Basis and Mechanism of Chiral Benzedrine Molecules Interacting With Third Dopamine Receptor. Chirality. 2016;28:674-85 pubmed publisher
    ..Tyr55, while Asn57, Asp133, Asp168, Cys172, Gly54, Trp24, and Vall136 act as the active residues for S-benzedrine (SAT). The different active pockets are observed for ART or SAT because they possess different active residues...
  60. Nam J, Kim J, Cho K, Choi Y, Choi J, Shin J, et al. Associations of sitting time and occupation with metabolic syndrome in South Korean adults: a cross-sectional study. BMC Public Health. 2016;16:943 pubmed publisher
    ..The risk of MS was 1.21-fold higher among participants who sat for >7 h/day than among those who sat for ?7 h/day (odds ratio [OR]: 1.21, 95 % confidence interval [CI]: 1...
  61. Dhat S, Pund S, Kokare C, Sharma P, Shrivastava B. Risk management and statistical multivariate analysis approach for design and optimization of satranidazole nanoparticles. Eur J Pharm Sci. 2017;96:273-283 pubmed publisher
    ..Poorly soluble, high dose drug, Satranidazole was optimally nanoprecipitated (SAT-NP) employing principles of Formulation by Design (FbD)...
  62. Honarvar B, Moghadami M, Lankarani K, Davarpanah M, Ataolahi M, Farbod A, et al. Brucellosis as a neglected disease in a neglected population: a seroepidemiological study of migratory nomads in the Fars province of Iran. Epidemiol Infect. 2017;145:491-497 pubmed publisher
    ..back pain, arthralgia, or myalgia, and positive laboratory testing, including either a serum agglutination test (SAT) ?1:80 with a 2-mercaptoethanol (2-ME) test ?1:40, or a SAT <1:80 combined with a positive Coombs Wright test (..
  63. Riem M, De Carli P, van IJzendoorn M, Linting M, Grewen K, Bakermans Kranenburg M. Emotional maltreatment is associated with atypical responding to stimulation of endogenous oxytocin release through mechanically-delivered massage in males. Psychoneuroendocrinology. 2017;85:115-122 pubmed publisher
    ..Effects of a 15-min massage session were compared to a control condition during which participants sat on a comfortable chair without a massage seat cover...
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    ..18, p=.006), lower Scholastic Aptitude Test (SAT) score (β=-0.13, p=.038), and greater externalizing symptoms (β=0.29, p<...
  65. De Souza L, Berger H, Retnakaran R, Maguire J, Nathens A, Connelly P, et al. First-Trimester Maternal Abdominal Adiposity Predicts Dysglycemia and Gestational Diabetes Mellitus in Midpregnancy. Diabetes Care. 2016;39:61-4 pubmed publisher
    ..In a prospective cohort of 485 women, we measured subcutaneous (SAT), visceral (VAT), and total (TAT) adipose tissue depth, using ultrasound at 11-14 weeks' gestation...
  66. Maciel J, Matter L, Trindade M, Camillo G, Lovato M, de Avila Botton S, et al. Virulence factors and antimicrobial susceptibility profile of extraintestinal Escherichia coli isolated from an avian colisepticemia outbreak. Microb Pathog. 2017;103:119-122 pubmed publisher
    ..chr., sitD. ep., iss, neuC, ompA, traT, astA, hlyA, sat, vat, pic, malX, cvi/cva) were tested...
  67. Gurkan A, Arisan E, Yerlikaya P, Ilhan H, Unsal N. Inhibition of autophagy enhances DENSpm-induced apoptosis in human colon cancer cells in a p53 independent manner. Cell Oncol (Dordr). 2018;41:297-317 pubmed publisher
    ..that apoptotic cell death was increased by PA depletion and spermidine/spermine N1-acetyltransferase (SSAT) upregulation...
  68. Helge J, Ayre K, Chaunchaiyakul S, Hulbert A, Kiens B, Storlien L. Endurance in high-fat-fed rats: effects of carbohydrate content and fatty acid profile. J Appl Physiol (1985). 1998;85:1342-8 pubmed
    ..diet or one of two fat-rich diets (65 E% fat, 20 E% protein, 15 E% carbohydrate) containing either saturated (Sat) or monounsaturated fatty acids (Mono)...
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    ..in the exercise condition performed low-intensity cycling (?40%HRR) for 15-min and those in the control condition sat quietly on the bike for 15-min...
  70. Saunders D, Melcher D, van Zoest W. No evidence of task co-representation in a joint Stroop task. Psychol Res. 2017;: pubmed publisher
    ..In Experiment 1, pairs of participants sat side by side...
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    ..Light-saturated photosynthetic CO2 assimilation rate (A sat ) was significantly higher in HL leaves than those of IL and LL leaves...
  72. Chen D, Jiang Y, Feng D, Wen S, Su D, Yang L. Integron mediated bacterial resistance and virulence on clinical pathogens. Microb Pathog. 2018;114:453-457 pubmed publisher
    ..This study offered a valid LAMP method in resistance integrons detection for laboratory use, which was time-saving and easy-determination. ..
  73. Brajkovic D, Ducharme M, Frim J. Relationship between body heat content and finger temperature during cold exposure. J Appl Physiol (1985). 2001;90:2445-52 pubmed
    ..temperature, finger dexterity, and rectal temperature were measured during active torso heating while the subjects sat in a chair and were exposed to -25 degrees C air...
  74. Markovich D. Physiological roles and regulation of mammalian sulfate transporters. Physiol Rev. 2001;81:1499-533 pubmed
    ..These include the renal sulfate transporters NaSi-1 and sat-1, the ubiquitously expressed diastrophic dysplasia sulfate transporter DTDST, the intestinal sulfate transporter ..
  75. Ishii T, Onda H, Tanigawa A, Ohshima S, Fujiwara H, Mima T, et al. Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients. DNA Res. 2005;12:429-39 pubmed
    ..Genes linked to IFN are well known to influence SLE, but several other novel genes unrelated to IFN signaling we report here would be useful to understand the pathophysiology of SLE. ..
  76. Mandal S, Mandal A, Park M. Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermine N¹-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells. Biochem J. 2015;468:435-47 pubmed publisher
    ..Taken together, these data provide strong evidence that the depletion of the polyamines spermidine and spermine leads to mitochondria-mediated apoptosis. ..
  77. Singh A, Ekka M, Kaushik A, Pandya V, Singh R, Banerjee S, et al. Substrate-Induced Facilitated Dissociation of the Competitive Inhibitor from the Active Site of O-Acetyl Serine Sulfhydrylase Reveals a Competitive-Allostery Mechanism. Biochemistry. 2017;56:5011-5025 pubmed publisher
    ..The competitive inhibition of O-acetyl serine sulfhydrylase (OASS) by the C-terminus of serine acetyltransferase (SAT) presents a paradox, because the C-terminus of SAT binds to the active site of OASS with an affinity that is 4-6 ..
  78. Liu F, Yang Z, Yu Y, Mei Y, Houk K. Bimodal Evans-Polanyi Relationships in Dioxirane Oxidations of sp3 C-H: Non-perfect Synchronization in Generation of Delocalized Radical Intermediates. J Am Chem Soc. 2017;139:16650-16656 pubmed publisher
    ..Activation energies correlate with reaction energies or, equivalently, BDEs (?Hsat = 0.91*BDE - 67.8)...
  79. Mulligan N, Rawson K, Peterson D, Wissman K. The Replicability of the Negative Testing Effect: Differences Across Participant Populations. J Exp Psychol Learn Mem Cogn. 2017;: pubmed publisher
    ..were assessed on several measures of cognitive ability (working memory capacity, Raven's progressive matrices, and SAT or ACT score)...
  80. Hegde S, Chandler J, Vetting M, Yu M, Blanchard J. Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. Biochemistry. 2007;46:7187-95 pubmed
    The N1-acetylation of spermidine and spermine by spermidine/spermine acetyltransferase (SSAT) is a crucial step in the regulation of the cellular polyamine levels in eukaryotic cells...
  81. Srivaratharajah K, Abramson B, Jairam J, Park A, Berger H, Ray J. Ethnic Differences in Visceral Adiposity Measured in Early Pregnancy. J Obstet Gynaecol Can. 2018;40:193-198 pubmed publisher
    To determine if visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) depth in early pregnancy differs by maternal ethnicity. We prospectively evaluated 482 women without pre-pregnancy diabetes...
  82. Berry A, Bucci M, Raggi C, Eriksson J, Guzzardi M, Nuutila P, et al. Dynamic changes in p66Shc mRNA expression in peripheral blood mononuclear cells following resistance training intervention in old frail women born to obese mothers: a pilot study. Aging Clin Exp Res. 2018;30:871-876 pubmed publisher
    ..P66Shc was assessed in peripheral blood mononuclear cells (PBMC) and in subcutaneous adipose tissue (SAT) before and after RT. Overall, OOM showed elevated p66Shc mRNA levels in the PBMC...
  83. Stahl M, Buscato M, Grimaldi R, Cardoso L, Ribeiro A. Low sat-structured fats enriched in ?-linolenic acid: physicochemical properties and crystallization characteristics. J Food Sci Technol. 2017;54:3391-3403 pubmed publisher
    ..It was possible to obtain a lipid formulation with features of plasticity and enhanced nutritional quality, compatible with several food applications...
  84. Pinto D, Coradin T, Laberty Robert C. Effect of anode polarization on biofilm formation and electron transfer in Shewanella oneidensis/graphite felt microbial fuel cells. Bioelectrochemistry. 2018;120:1-9 pubmed publisher
    ..3V and +0.5V (vs. Ag/AgCl/KCl sat.) and its converse application to a couple of electrodes leads to different electrochemical behaviors, anodic ..
  85. Ikegami M, Whitsett J, Jobe A, Ross G, Fisher J, Korfhagen T. Surfactant metabolism in SP-D gene-targeted mice. Am J Physiol Lung Cell Mol Physiol. 2000;279:L468-76 pubmed
    ..Relative to saturated phosphatidylcholine (Sat PC), SP-A and SP-C were decreased in the alveolar surfactant and the large-aggregate surfactant fraction...
  86. Ikegami M, Hull W, Yoshida M, Wert S, Whitsett J. SP-D and GM-CSF regulate surfactant homeostasis via distinct mechanisms. Am J Physiol Lung Cell Mol Physiol. 2001;281:L697-703 pubmed
    ..Saturated phosphatidylcholine (Sat PC) pool sizes were markedly increased in SP-D(-/-),GM(-/-) mice, with the effects of each gene deletion on ..
  87. Chen Y, Zhang C. Preparation of Antispermidine/Spermine-N1-Acetyltransferase Monoclonal Antibodies. Monoclon Antib Immunodiagn Immunother. 2016;35:163-6 pubmed publisher
    Spermidine/spermine N1-acetyltransferase (SSAT) is a catabolic regulator of polyamines, ubiquitous molecules essential for cell proliferation and differentiation...
  88. Tise C, Perry J, Anforth L, Pavlovich M, Backman J, Ryan K, et al. From Genotype to Phenotype: Nonsense Variants in SLC13A1 Are Associated with Decreased Serum Sulfate and Increased Serum Aminotransferases. G3 (Bethesda). 2016;6:2909-18 pubmed publisher
  89. Dai F, Yu W, Song J, Li Q, Wang C, Xie S. Extracellular polyamines-induced proliferation and migration of cancer cells by ODC, SSAT, and Akt1-mediated pathway. Anticancer Drugs. 2017;28:457-464 pubmed publisher
    ..Polyamines upregulated the expression of ornithine decarboxylase (ODC), SSAT, Akt1, Akt, hypoxia-inducible factors-1α, vascular endothelial growth factor, and matrix metalloproteinases, and ..
  90. Park Y, Erickson C, Bessesen D, Van Pelt R, Cox York K. Age- and menopause-related differences in subcutaneous adipose tissue estrogen receptor mRNA expression. Steroids. 2017;121:17-21 pubmed publisher
    ..the current study was to determine whether ER gene expression in abdominal and femoral subcutaneous adipose tissue (SAT) was associated with age, menopause, or regional adiposity...
  91. Renehan E, Goeman D, Koch S. Development of an optimised key worker framework for people with dementia, their family and caring unit living in the community. BMC Health Serv Res. 2017;17:501 pubmed publisher
    ..A number of more clearly defined sub-themes sat under each component...
  92. Yang X, Jiang Y, Han G, Shi Y, Zhou S, Ni F, et al. Altered Adipose-Derived Stem Cell Characteristics in Macrodactyly. Sci Rep. 2017;7:11090 pubmed publisher
    ..Mac-ASCs) were isolated and compared to ASCs derived from the normal abdominal subcutaneous adipose tissue (Sat-ASCs) for cell morphology, surface marker expression, proliferation rate, and tri-lineage differentiation potential...