SPAG11B

Summary

Gene Symbol: SPAG11B
Description: sperm associated antigen 11B
Alias: EDDM2B, EP2, EP2C, EP2D, HE2, HE2C, SPAG11, epididymal protein 2B, human epididymis-specific protein 2, sperm antigen HE2, sperm-associated antigen 11B
Species: human

Top Publications

  1. ncbi Immunogenicity and specificity of the candidate multi-epitope-vaccines against HIV-1
    Y Lu
    Research Center for Medical Science and Department of Biology, Tsinghua University, Ministry of Education, Beijing, PR China
    Immunopharmacol Immunotoxicol 23:487-94. 2001
  2. pmc Inhibition of noradrenaline release in the rat vena cava via prostanoid receptors of the EP3-subtype
    G Molderings
    , , Germany
    Br J Pharmacol 107:352-5. 1992
  3. pmc Modulation of noradrenaline release from the sympathetic nerves of the human saphenous vein and pulmonary artery by presynaptic EP3- and DP-receptors
    G J Molderings
    , , Germany
    Br J Pharmacol 111:733-8. 1994
  4. pmc Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils
    E Talpain
    Department of Pharmacology, University of Edinburgh
    Br J Pharmacol 114:1459-65. 1995
  5. doi Cyclooxygenase-2-derived prostaglandin E2 is involved in vascular endothelial growth factor production in interleukin-1alpha-stimulated human periodontal ligament cells
    Y Bando
    Periodontology, Department of Hard Tissue Engineering, Tokyo Medical and Dental University, Tokyo, Japan
    J Periodontal Res 44:395-401. 2009
  6. ncbi Characterization of chlorinated compounds using a dual chlorine-selective pulsed discharge emission detector-helium-pulsed discharge photoionization detector system
    K Sun
    Department of Chemistry, University of Houston, TX 77204-5641, USA
    J Chromatogr A 872:179-89. 2000
  7. ncbi Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins
    Y Huang
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 273:17483-90. 1998
  8. ncbi Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists
    S Shinomiya
    Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Biochem Pharmacol 61:1153-60. 2001
  9. ncbi Prostaglandin receptors: their role in regulating renal function
    M D Breyer
    Department of Medicine, Department of Veterans Affairs Medical Center, Vanderbilt University, Nashville, Tennessee, USA
    Curr Opin Nephrol Hypertens 9:23-9. 2000
  10. ncbi Prostaglandin E receptors in myometrial cells
    G Asboth
    1st Institute of Biochemistry, Semmelweis University of Medicine, Budapest, Hungary
    Acta Physiol Hung 85:39-50. 1997

Research Grants

Detail Information

Publications196 found, 100 shown here

  1. ncbi Immunogenicity and specificity of the candidate multi-epitope-vaccines against HIV-1
    Y Lu
    Research Center for Medical Science and Department of Biology, Tsinghua University, Ministry of Education, Beijing, PR China
    Immunopharmacol Immunotoxicol 23:487-94. 2001
    ..antibodies against HIV-1, we designed two candidate multi-epitope-vaccines, EP1 [C-G-(ELDKWA-GPGRAFY)2-K] and EP2 (CG-GPGRAFY-G-ELDKWA-G-RILAVERYLKD), containing three neutralizing epitopes (GPGRAFY, ELDKWA and RILAVERYLKD) on ..
  2. pmc Inhibition of noradrenaline release in the rat vena cava via prostanoid receptors of the EP3-subtype
    G Molderings
    , , Germany
    Br J Pharmacol 107:352-5. 1992
    ..compounds mimicked the effect of prostaglandin E2 showing the following rank order of potencies: misoprostol (EP2-/EP3-receptor agonist) congruent to sulprostone (EP1-/EP3-receptor agonist) congruent to prostaglandin E1 = ..
  3. pmc Modulation of noradrenaline release from the sympathetic nerves of the human saphenous vein and pulmonary artery by presynaptic EP3- and DP-receptors
    G J Molderings
    , , Germany
    Br J Pharmacol 111:733-8. 1994
    ..00. These effects were mimicked by prostaglandin E1, the EP1/EP3 receptor agonist, sulprostone and the EP2/EP3 receptor agonist, misoprostol with the rank order (pEC50): sulprostone (8.60) > PGE1 (7...
  4. pmc Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils
    E Talpain
    Department of Pharmacology, University of Edinburgh
    Br J Pharmacol 114:1459-65. 1995
    ..15 +/- 0.03 microM, and a maximum effect ranging from 36-84% (mean inhibition of 68.7 +/- 2.5%, n = 32). 3. The EP2-receptor agonists, misoprostol, 11-deoxy PGE1, AH13205 and butaprost, all at 10 microM, inhibited O2- generation, ..
  5. doi Cyclooxygenase-2-derived prostaglandin E2 is involved in vascular endothelial growth factor production in interleukin-1alpha-stimulated human periodontal ligament cells
    Y Bando
    Periodontology, Department of Hard Tissue Engineering, Tokyo Medical and Dental University, Tokyo, Japan
    J Periodontal Res 44:395-401. 2009
    Prostaglandin E(2), which exerts its actions via EP receptors (EP1, EP2, EP3 and EP4), is a bioactive metabolite of arachidonic acid produced by cyclooxygenase-1 and/or cyclooxygenase-2...
  6. ncbi Characterization of chlorinated compounds using a dual chlorine-selective pulsed discharge emission detector-helium-pulsed discharge photoionization detector system
    K Sun
    Department of Chemistry, University of Houston, TX 77204-5641, USA
    J Chromatogr A 872:179-89. 2000
    ..detector (He-PDPID) is a function of the molecular structure and the number of photoionizable electrons using the He2 band at 13.5-17.5 eV...
  7. ncbi Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins
    Y Huang
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 273:17483-90. 1998
    ..effect of apoE2, we bred transgenic mice expressing low levels of apoE2 with LDL receptor-null mice (hE2(+/0), LDLR-/-)...
  8. ncbi Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists
    S Shinomiya
    Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Biochem Pharmacol 61:1153-60. 2001
    ..Among prostaglandin E (EP) receptor-selective synthetic agonists, EP2 and EP4 agonists caused down-regulation of the zymosan-induced TNFalpha production, but up-regulation on the IL-10 ..
  9. ncbi Prostaglandin receptors: their role in regulating renal function
    M D Breyer
    Department of Medicine, Department of Veterans Affairs Medical Center, Vanderbilt University, Nashville, Tennessee, USA
    Curr Opin Nephrol Hypertens 9:23-9. 2000
    ..The FP, TP, and EP1 receptors preferentially couple to increased cell Ca2+. EP2, EP4, DP, and IP receptors stimulate cyclic adenosine monophosphate, whereas the EP3 receptor preferentially ..
  10. ncbi Prostaglandin E receptors in myometrial cells
    G Asboth
    1st Institute of Biochemistry, Semmelweis University of Medicine, Budapest, Hungary
    Acta Physiol Hung 85:39-50. 1997
    ..PGE2 may interact with at least four receptor subtypes (EP1, EP2, EP3, EP4), each showing different pharmacological profiles...
  11. ncbi [Effects of experimental left varicocele on SPAG11 mRNA and SPAG11E in the testis and epididymis of adolescent rats]
    Hong Tian
    Department of Human Anatomy, Histology and Embryology, Medical School of Xi an Jiaotong University, Xi an, Shaanxi 710061, China
    Zhonghua Nan Ke Xue 14:200-5. 2008
    To investigate the effects of experimental left varicocele (ELV) on the expression of sperm associated antigen 11 (SPAG11) mRNA and its protein isomer SPAG11E in the testis and epididymis of adolescent rats, and to explore the mechanism ..
  12. pmc Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea-pig ileum
    R A Lawrence
    Department of Pharmacology, University of Edinburgh
    Br J Pharmacol 105:271-8. 1992
    ..b>EP2-receptors may be involved in the PGE action, in view of the marked effect of morphine on the contractile actions of ..
  13. ncbi Long-term efficacy of antifungals in toenail onychomycosis: a critical review
    B J Cribier
    Clinique Dermatologique des Hôpitaux Universitaires, 1 place de l Hôpital 67091 Strasbourg, France
    Br J Dermatol 145:446-52. 2001
    ..Modern antifungal drugs achieve high mycological and clinical cure rates in onychomycosis of the toes, but little is known about the long-term evolution of the treated patients...
  14. ncbi Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Rolf M Nusing
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt 60590, Germany
    J Am Soc Nephrol 16:2354-62. 2005
    ..In wild-type (WT) mice and in mice lacking distinct PGE2 receptors (EP1-/-, EP2-/-, EP3-/-, and EP4-/-), the effect of chronic furosemide administration (7 d) on urine output, sodium and ..
  15. pmc Heterologous replacement of the supposed host determining region of avihepadnaviruses: high in vivo infectivity despite low infectivity for hepatocytes
    Kai Dallmeier
    University Hospital Freiburg, Freiburg, Germany
    PLoS Pathog 4:e1000230. 2008
    ..chimeric DHBVs with L proteins in which segments 22-90 (Du-He4) or its subsegments 22-37 and 37-90 (Du-He2, Du-He3) are derived from HHBV...
  16. ncbi Evidence for the presence of AH 13205-sensitive EP2-prostanoid receptors in the pregnant baboon but not in the pregnant sheep myometrium near term
    R Garcia-Villar
    Department of Physiology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 6401, USA
    J Soc Gynecol Investig 2:6-12. 1995
    ..in pregnant sheep and baboons in an in vitro superfusion study, and to characterize further the PGE-sensitive (EP) receptor subtype involved in the myometrial response to PGE2 by using the selective prostanoid EP2 agonist AH 13205.
  17. pmc Ontogenic increase in PGE2 and PGF2 alpha receptor density in brain microvessels of pigs
    D Y Li
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
    Br J Pharmacol 112:59-64. 1994
    ..displaced by AH 6809 (EP1-selective antagonist) by 80-90%, and only by approximately 30-35% by both 11-deoxy PGE1 (EP2/EP3 agonist) and M&B 28,767 (EP3 agonist); butaprost (EP2 agonist) was completely ineffective. 4...
  18. ncbi Immunohistochemical demonstration of cyclooxygenase-2 (COX-2) and prostaglandin receptors EP2 and FP expression in the bovine intercaruncular uterine wall around term
    D Wehbrink
    Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Anim Reprod Sci 106:241-54. 2008
    ..In contrast to relaxant prostaglandin E receptor type 2 (EP2), not showing any change in all tissue layers observed, contractile prostaglandin F(2alpha) receptor (FP) was ..
  19. pmc Characterization of the prostanoid receptor(s) on human blood monocytes at which prostaglandin E2 inhibits lipopolysaccharide-induced tumour necrosis factor-alpha generation
    K K Meja
    Imperial College School of Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 122:149-57. 1997
    ..4. With respect to PGE2, the EP-receptor agonists, 16,16-dimethyl PGE2 (non-selective), misoprostol (EP2/EP3-selective), 11-deoxy PGE1 (EP2-selective) and butaprost (EP2-selective) were essentially full agonists as ..
  20. ncbi Prostanoid receptors of murine NIH 3T3 and RAW 264.7 cells. Structure and expression of the murine prostaglandin EP4 receptor gene
    T Arakawa
    Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 271:29569-75. 1996
    ..The levels of the EP2 and EP4 prostaglandin E2 (PGE2) receptors and the prostaglandin I2 receptor were changed in these cells by serum or ..
  21. pmc Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1beta production
    A O Caggiano
    Committee on Neurobiology, University of Chicago, Illinois 60637, USA
    J Neurochem 72:565-75. 1999
    ..e., EP1, EP2, EP3, and EP4, expression and function in cultured rat microglia...
  22. ncbi Effects of mechanical strain on the function of Gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor
    Priscilla P Cherian
    Department of Biochemistry and Radiology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 278:43146-56. 2003
    ..Here we show that fluid flow regulates gap junctions through the PGE2 receptor EP2 activation of cAMP-dependent protein kinase A (PKA) signaling...
  23. pmc Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein
    R A Lawrence
    Department of Pharmacology, University of Edinburgh
    Br J Pharmacol 105:817-24. 1992
    ..3. Comparison of the jugular vein data with published data for inhibitory agonist potencies on the cat trachea (EP2 preparation) and the field-stimulated guinea-pig vas deferens (EP3) indicates that the EP-receptor in the rabbit ..
  24. ncbi Spinal prostaglandin E receptors of the EP2 subtype and the glycine receptor alpha3 subunit, which mediate central inflammatory hyperalgesia, do not contribute to pain after peripheral nerve injury or formalin injection
    Katharina Hösl
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Pain 126:46-53. 2006
    ..We have recently identified spinal prostaglandin E receptors of the EP2 subtype (EP2 receptors) and the glycine receptor alpha3 subunit (GlyR alpha3) as signal transduction elements ..
  25. pmc Potentiation of aggregation and inhibition of adenylate cyclase in human platelets by prostaglandin E analogues
    J S Matthews
    Department of Pharmacology, University of Edinburgh, Scotland
    Br J Pharmacol 108:363-9. 1993
    ..3) suggest the involvement of EP3-receptors as opposed to EP1- or EP2-subtypes. 2...
  26. pmc Antimicrobial actions of the human epididymis 2 (HE2) protein isoforms, HE2alpha, HE2beta1 and HE2beta2
    Suresh Yenugu
    Laboratories for Reproductive Biology, Department of Pediatrics, University of North Carolina, Chapel Hill, NC 27599 7500, USA
    Reprod Biol Endocrinol 2:61. 2004
    The HE2 gene encodes a group of isoforms with similarities to the antimicrobial beta-defensins...
  27. doi A cyclooxygenase-2/prostaglandin E2 pathway augments activation-induced cytosine deaminase expression within replicating human B cells
    Hyunjoo Lee
    Laboratory of B Cell Biology, Karches Center for Chronic Lymphocytic Leukemia Research, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 185:5300-14. 2010
    ..paralleled by a division-related increase in a COX-2-linked enzyme, microsomal PGE(2) synthase-1, and the PGE(2)R, EP2. Cells with the greatest expression of AID expressed the highest levels of EP2...
  28. doi CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid c
    Chandra Prakash
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton, Connecticut, USA
    Drug Metab Dispos 36:2093-103. 2008
    CP-533,536, (3-{[(4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (1), an EP2 receptor-selective prostaglandin E2 agonist, is being developed to aid in the healing of bone fractures...
  29. pmc In vitro characterization of prostanoid receptors on human myometrium at term pregnancy
    J Senior
    Postgraduate Studies in Pharmacology, University of Bradford
    Br J Pharmacol 108:501-6. 1993
    ..The EP2/EP3-receptor agonists, rioprostil and misoprostol, produced similar effects to PGE2, however, the excitatory event ..
  30. pmc Expression of eicosanoid receptors subtypes and eosinophilic inflammation: implication on chronic rhinosinusitis
    Claudina Angela Perez-Novo
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 85, Ghent, Belgium
    Respir Res 7:75. 2006
    ..We aimed with this study to investigate the tissue expression of leukotrienes and prostaglandin E2 receptors in chronic rhinosinusitis patients and the link of this regulation with eosinophilic inflammation...
  31. ncbi An investigation of the effect of the prostaglandin EP2 receptor agonist, butaprost, on the human isolated myometrium from pregnant and non-pregnant women
    N Duckworth
    School of Pharmacy, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK
    J Endocrinol 172:263-9. 2002
    ..and the stable thromboxane receptor mimetic, U46619, on human myometrium treated with the prostaglandin E receptor (EP2) agonist, butaprost (selective for the EP2 receptor)...
  32. pmc Characterization of EP-receptor subtypes involved in allodynia and hyperalgesia induced by intrathecal administration of prostaglandin E2 to mice
    T Minami
    Department of Anesthesiology, Osaka Medical College, Takatsuki, Japan
    Br J Pharmacol 112:735-40. 1994
    ..3. 17-Phenyl-omega-trinor PGE2 (EP1 > EP3) and 16,16-dimethyl PGE2 (EP1 = EP2 = EP3) were as potent as PGE2 in inducing allodynia, and more potent than sulprostone...
  33. doi PGE2 signal via EP2 receptors evoked by a selective agonist enhances regeneration of injured articular cartilage
    S Otsuka
    Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Osteoarthritis Cartilage 17:529-38. 2009
    The effect of the prostaglandin E2 (PGE2) signal through prostaglandin E receptor 2 (EP2) receptors on the repair of injured articular cartilage was investigated using a selective agonist for EP2.
  34. pmc Role of prostaglandin E receptor subtypes EP2 and EP4 in autocrine and paracrine functions of vascular endothelial growth factor in the inner ear
    Ryusuke Hori
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyo ku, 606 8507 Kyoto, Japan
    BMC Neurosci 11:35. 2010
    ..of prostaglandin E1 (PGE1) and prostaglandin E2 (PGE2) are mediated by the prostaglandin E receptor subtypes EP1, EP2, EP3, and EP4, and the respective agonists have been purified...
  35. ncbi Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice
    M Sonoshita
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Nat Med 7:1048-51. 2001
    ..Here we show that homozygous deletion of the gene encoding a cell-surface receptor of PGE(2), EP2, causes decreases in number and size of intestinal polyps in Apc(Delta 716) mice (a mouse model for human familial ..
  36. ncbi Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury
    Peng Zhao
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 27:2357-68. 2007
    ..regulator of PGE2 release, to microglial cells and a neuronal localization of the PGE2 receptor E-prostanoid 2 (EP2)...
  37. doi The effect of estradiol on COX-2, EP2, and EP4 mRNA expression and the extracellular matrix in the cervix of the hypogonadotrophic, ovariectomized ewe
    C M Kershaw-Young
    Department of Veterinary Clinical Sciences, The Royal Veterinary College, North Mymms, Hatfield, Hertfordshire, United Kingdom
    Theriogenology 73:620-8. 2010
    ..05). In conclusion, we inferred that estradiol regulates cervical COX-2 and EP(4) mRNA expression and may regulate cervical relaxation via the synthesis of prostaglandin E(2) and activation of the PGE(2) receptors EP(2) and EP(4)...
  38. ncbi Prostaglandin receptors EP2 and IP are detectable in atherosclerotic arteries and plaques
    A Muto
    Section of Vascular Surgery, Yale University School of Medicine, New Haven, CT, USA
    Int Angiol 29:43-8. 2010
    ..In particular, the PG receptors EP2 and IP stimulate vasodilation and inhibit platelet aggregation, biological processes thought to be protective ..
  39. doi Prostaglandin E2 derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2
    Jacques Q van der Merwe
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    J Pharmacol Exp Ther 329:747-52. 2009
    ..Immunofluorescence and immunoblot analysis determined that EP2 and EP4 are expressed at the basolateral membrane of SCBN cells...
  40. ncbi Copresence of prostaglandin EP2 and EP3 receptors on gastric enterochromaffin-like cell carcinoid in African rodents
    Y Naribayashi-Inomoto
    Department of Internal Medicine, Kobe University School of Medicine, Japan
    Gastroenterology 109:341-7. 1995
    ..The aim of this study was to examine the possible presence of PG receptors on the gastric enterochromaffin-like (ECL) carcinoid of Mastomys natalensis, which might be a useful model of normal ECL cells...
  41. ncbi A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing
    Mei Li
    Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton Laboratories, Groton, Connecticut 06340, USA
    J Bone Miner Res 18:2033-42. 2003
    CP-533,536, a newly discovered, non-prostanoid EP2 receptor-selective PGE2 agonist, stimulates local bone formation and enhances fracture healing in rat models.
  42. pmc Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E₂ and prostaglandin E₂ receptors
    Tripti Singh
    Department of Dermatology, University of Alabama at Birmingham, 35294, USA
    Carcinogenesis 32:86-92. 2011
    ..of these cells, which was associated with a reduction in the levels of COX-2, PGE₂ and PGE₂ receptors (EP2 and EP4)...
  43. ncbi EP2 receptor mediates PGE2-induced cystogenesis of human renal epithelial cells
    Gerard Elberg
    Department of Pediatrics, The University of Oklahoma Health Sciences Center, 940 N E 13th St, 2B2309, Oklahoma City, OK 73104, USA
    Am J Physiol Renal Physiol 293:F1622-32. 2007
    ..Biochemical evidence gathered by using real-time RT-PCR mRNA analysis and immunodetection indicate the presence of EP2 receptor in cystic epithelial cells in ADPKD kidney...
  44. ncbi Potential sites of prostaglandin actions in the periimplantation mouse uterus: differential expression and regulation of prostaglandin receptor genes
    Z M Yang
    Department of Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7336, USA
    Biol Reprod 56:368-79. 1997
    ..PGE2 receptors are classified into four subtypes, EP1, EP2, EP3, and EP4...
  45. ncbi Facilitation by endogenous prostaglandins of capsaicin-induced gastric protection in rodents through EP2 and IP receptors
    Koji Takeuchi
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
    J Pharmacol Exp Ther 304:1055-62. 2003
    ..Although neither butaprost (EP2), ONO-NT-012 (EP3), nor 11-deoxy PGE1 (EP4) alone had any effect on HCl/ethanol-induced gastric lesions, only ..
  46. ncbi Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4A methylation and an unfavorable prognosis
    Mohamed Alaa
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Oncol 34:805-12. 2009
    ..In this study, we examined the correlation between PGE2 receptor 2 (EP2) expression and p16INK4A methylation in NSCLC, and the association with clinicopathological features and prognostic ..
  47. pmc The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development
    Kyung Soo Chun
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 30:1620-7. 2009
    ..To investigate PGE(2)'s roles, the contributions of one of its receptors, EP2, were studied using the mouse skin initiation/promotion model...
  48. ncbi EP1- and EP3-receptors mediate prostaglandin E2-induced constriction of porcine large cerebral arteries
    Vikram Jadhav
    Department of Pharmacology, Southern Illinois University, School of Medicine, Springfield, Illinois 62794 9629, USA
    J Cereb Blood Flow Metab 24:1305-16. 2004
    ..trinor PGE2 (17-PGE2), sulprostone (EP1/EP3 receptor agonists), and 11-deoxy-16,16-dimethyl PGE2 (11-PGE2, an EP2/EP3-receptor agonist) induced exclusive constriction, which was not affected by endothelium denudation or cold-..
  49. ncbi Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice
    C Miyaura
    Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 275:19819-23. 2000
    ..and then identified PGE receptor subtype(s) mediating this PGE(2) action using mice lacking each subtype (EP1, EP2, EP3, and EP4) of PGE receptor...
  50. ncbi Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2
    Hiromichi Fujino
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721 0207, USA
    J Biol Chem 277:2614-9. 2002
    ..This is the first indication of a fundamental difference in the signaling potential of EP(2) and EP(4) prostanoid receptors...
  51. ncbi A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors
    Yukihiko Sugimoto
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 279:11016-26. 2004
    To assess the structural requirements for G(s) coupling by prostaglandin E receptors (EPs), the G(s)-coupled EP2 and G(i)-coupled EP3beta receptors were used to generate hybrid receptors...
  52. ncbi 'Distinct cellular localization' of the messenger ribonucleic acid for prostaglandin E receptor subtypes in the mouse uterus during pseudopregnancy
    M Katsuyama
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    Endocrinology 138:344-50. 1997
    ..uterine actions of PGE2, expression patterns of the messenger RNAs (mRNAs) for four subtypes of PGE receptors, EP1, EP2, EP3, and EP4, were investigated in the mouse uterus during pseudopregnancy...
  53. pmc Potent contractile actions of prostanoid EP3-receptor agonists on human isolated pulmonary artery
    Y M Qian
    Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, New Territories
    Br J Pharmacol 113:369-74. 1994
    ..Phenylephrine-induced tone was also inhibited by PGE2 (EC50 = 5-20 nM), 11-deoxy PGE1 and butaprost (a selective EP2-receptor agonist); the latter prostanoids were about 2 and 4 times less potent than PGE2 respectively...
  54. pmc A comparative study of the prostanoid receptor profile of 9 alpha 11 beta-prostaglandin F2 and prostaglandin D2
    H Giles
    Analytical Pharmacology Group, Wellcome Research Laboratories, Beckenham, Kent
    Br J Pharmacol 104:541-9. 1991
    ..tissues; the lack of selective antagonists for each receptor means that conclusions regarding efficacy at FP and EP2 receptors must remain provisional. 2...
  55. ncbi A novel inhibitory prostanoid receptor in piglet saphenous vein
    R A Coleman
    Department of Cardiovascular and Respiratory Pharmacology, Glaxo Group Research Ltd, Ware, Herts
    Prostaglandins 47:151-68. 1994
    ..The selective synthetic EP-agonists, sulprostone (EP1/EP3) and AH13205X (EP2), were next tested for relaxant activity...
  56. ncbi Stimulatory (EP1 and EP3) and inhibitory (EP2) prostaglandin E2 receptors in isolated ileal smooth muscle cells
    A Botella
    Department of Pharmacology, INRA, Toulouse, France
    Eur J Pharmacol 237:131-7. 1993
    ..to study the effect of prostaglandin E2 (PGE2) and three PGE2 receptor (EP) agonists; iloprost (EP1), butaprost (EP2) and enprostil (EP3). In pig cells, PGE2 and enprostil induced cell contraction (22.1 and 21...
  57. pmc Cloning and expression of the rabbit prostaglandin EP2 receptor
    Youfei Guan
    Division of Nephrolgy, Veterans Administration Medical Center, and Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2372, USA
    BMC Pharmacol 2:14. 2002
    ..Evidence supports an important role for the EP2 receptor in regulating fertility, vascular tone and renal function.
  58. pmc Increased dietary NaCl induces renal medullary PGE2 production and natriuresis via the EP2 receptor
    Jian Chen
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Physiol Renal Physiol 295:F818-25. 2008
    ..02 to 0.32 +/- 0.05 mueq/min). The natriuretic effect of intramedullary PGE(2) or butaprost was abolished in EP2-deficient mice, which exhibit NaCl-dependent hypertension...
  59. pmc The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
    Kenji Kabashima
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Clin Invest 109:883-93. 2002
    ..Among the prostanoid receptor-deficient mice, only EP4-deficient mice and not mice deficient in either DP, EP1, EP2, EP3, FP, IP, or TP developed severe colitis with 3% DSS treatment, which induced only marginal colitis in wild-..
  60. doi NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors
    Vivian Y Shin
    Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Carcinogenesis 32:240-5. 2011
    ..E₂ (PGE₂) signaling in response to nicotine was mediated by the action of prostaglandin E receptors (EP2 and EP4)...
  61. pmc Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene
    M Hirata
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    Proc Natl Acad Sci U S A 91:11192-6. 1994
    ..The deduced amino acid sequence has a high degree of similarity with the mouse PGI receptor and the EP2 subtype of the PGE receptor, which together form a subgroup of the prostanoid receptors...
  62. doi Modulation of pentylenetetrazol-induced seizures by prostaglandin E2 receptors
    M S Oliveira
    Departamento de Fisiologia e Farmacologia, Centro de Ciencias da Saude, Universidade Federal de Santa Maria, 97105 900 Santa Maria, RS, Brazil
    Neuroscience 152:1110-8. 2008
    ..c.v.), EP3 (L-826266, 1 nmol, i.c.v.) and EP4 (L-161982, 750 pmol, i.c.v.) receptors, and the selective EP2 agonist butaprost (100 pmol, i.c.v...
  63. pmc Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation
    Teresa G Tessner
    Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 114:1676-85. 2004
    ..The in vitro studies indicate that dmPGE2, most likely by signaling through the E prostaglandin receptor EP2, reduces radiation-induced apoptosis through transactivation of the EGFR and enhanced activation of AKT and that ..
  64. doi Expression of receptors for ovarian steroids and prostaglandin E2 in the endometrium and myometrium of mares during estrus, diestrus and early pregnancy
    E S M Silva
    Faculdade de Medicina Veterinaria e Zootecnia, UNESP Universidade Estadual Paulista, Departamento de Reprodução Animal e Radiologia Veterinária, Botucatu, Sao Paulo, CEP 18618 970, Brazil
    Anim Reprod Sci 151:169-81. 2014
    ..of estrogen receptor alpha (ER-α), β (ER-β), progesterone receptor (PR), as well as prostaglandin E2 type 2 (EP2) and 4 (EP4) receptors in the equine myometrium and endometrium during estrus, diestrus and early pregnancy...
  65. ncbi Prostaglandin E2 activates outwardly rectifying Cl(-) channels via a cAMP-dependent pathway and reduces cell motility in rat osteoclasts
    Fujio Okamoto
    Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Fukuoka, Japan 814 0193
    Am J Physiol Cell Physiol 287:C114-24. 2004
    ..PGE(2) is known to exert its effects through four subtypes of PGE receptors (EP1-EP4). EP2 and EP4 agonists (ONO-AE1-259 and ONO-AE1-329, respectively), but not EP1 and EP3 agonists (ONO-DI-004 and ONO-AE-..
  66. pmc Prostaglandin E2 promotes endothelial differentiation from bone marrow-derived cells through AMPK activation
    Zhenjiu Zhu
    Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    PLoS ONE 6:e23554. 2011
    ..were both increased which could be blocked by EP4 blocking peptide and simulated by the agonist of EP4 but not EP1, EP2 or EP3. The pro-angiogenic role of PGE2 could be repressed by EP4 blocking peptide and retarded in EP4(+/-) mice...
  67. pmc Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells
    Kang Jin Jeong
    Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 302 718, Korea
    Exp Mol Med 40:607-16. 2008
    ..LPA stimulated CAOV-3 cell migration that was abrogated by pharmacological inhibitors and antibody of EP2. Higher expression of LPA2 mRNA was observed in CAOV-3 cells, and transfection of the cells with a selective LPA2 ..
  68. pmc Lead optimization studies of cinnamic amide EP2 antagonists
    Thota Ganesh
    Department of Pharmacology, School of Medicine, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States
    J Med Chem 57:4173-84. 2014
    Prostanoid receptor EP2 can play a proinflammatory role, exacerbating disease pathology in a variety of central nervous system and peripheral diseases...
  69. pmc Prostaglandin E(2) (PGE (2)) suppresses natural killer cell function primarily through the PGE(2) receptor EP4
    Dawn Holt
    Department of Pathology, School of Medicine, University of Maryland, Baltimore, USA
    Cancer Immunol Immunother 60:1577-86. 2011
    ..The EP2 agonist, Butaprost, inhibited migration to specific chemokines but not in response to FBS...
  70. ncbi Regulation of renal function by prostaglandin E receptors
    M D Breyer
    Department of Veterans Affairs Medical Center and Vanderbilt University, Nashville, Tennessee, USA
    Kidney Int Suppl 67:S88-94. 1998
    ..EP4 mRNA is readily detected in the CD with little detectable EP2 expression. The EP4 receptor appears to be expressed both on luminal and basolateral membranes...
  71. ncbi Prostaglandin receptor EP2 is responsible for cyclooxygenase-2 induction by prostaglandin E2 in mouse skin
    Kausar M Ansari
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, PO Box 389, Smithville, TX 78957, USA
    Carcinogenesis 28:2063-8. 2007
    The EP2 prostanoid receptor is one of the four subtypes of receptors for prostaglandin E2 (PGE2)...
  72. pmc Radiation-induced PGE2 sustains human glioma cells growth and survival through EGF signaling
    Emeline Brocard
    Centre de Recherche en Cancérologie Nantes Angers UMR INSERM 892, CNRS 6299, Universite de Nantes, 44007 Nantes, France
    Oncotarget 6:6840-9. 2015
    ..Indeed, PGE2 can substitute for EGF to promote primary cultures survival and growth in vitro and the effect is likely to occur though the Prostaglandin E2 receptor EP2.
  73. ncbi Modulation of noradrenaline release from the sympathetic nerves of human right atrial appendages by presynaptic EP3- and DP-receptors
    G J Molderings
    Institut fur Pharmakologie und Toxikologie, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Naunyn Schmiedebergs Arch Pharmacol 358:440-4. 1998
    ..evoked tritium overflow was mimicked by prostaglandin E1, the EP1/EP3-receptor agonist sulprostone and the EP2/EP3-receptor agonist misoprostol with the rank order of potency (pEC50%): sulprostone (7.68) > misoprostol (7...
  74. doi Temporal expression of the PGE2 synthetic system in the kidney is associated with the time frame of renal developmental vulnerability to cyclooxygenase-2 inhibition
    Stefanie Frölich
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
    Am J Physiol Renal Physiol 303:F209-19. 2012
    ..Studying glomerulogenesis in EP receptor knockout mice revealed a reduction in glomerular size in EP1(-/-), EP2(-/-), and EP4(-/-) mice, supporting the developmental role of PGE(2)...
  75. ncbi Regulation of growth and melanogenesis of uveal melanocytes
    D N Hu
    Tissue Culture Center, Department of Pathology and Laboratory Medicine, The New York Eye and Ear Infirmary, New York 10003, USA
    Pigment Cell Res 13:81-6. 2000
    ..endothelin, adrenergic beta2-receptor agonists, and some prostaglandins (EP2-receptor agonists and certain TP-receptor agonists) stimulate, while transforming growth factor-beta2, interleukin-..
  76. doi Effect of enrichment procedures on performance and microbial diversity of microbial fuel cell for Congo red decolorization and electricity generation
    Bin Hou
    State Key Laboratory of Pulp and Paper Engineering, Department of Environmental Science and Engineering, South China University of Technology, Guangzhou, China
    Appl Microbiol Biotechnol 90:1563-72. 2011
    ..enrichment procedures in which glucose and Congo red were added into the MFCs sequentially (EP1) or simultaneously (EP2) were tested by operating parallel MFCs independently for more than 6 months...
  77. doi Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease
    M Wang
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA
    J Intern Med 263:500-5. 2008
    ..This occurs despite the potential of the suppressed PGE2 in affording cardioprotection via its EP2 and EP4 receptors...
  78. doi The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells
    Eun Hee Han
    Department of Toxicology, College of Pharmacy, Chungnam National University, 220 Gung Dong, Daejeon 305 764, Yuseong Gu, South Korea
    Toxicol Lett 198:331-41. 2010
    ..induction of aromatase was inhibited by various inhibitors [COX-2 (by NS-398), PKA (H-89), PI3-K/Akt (LY 294002), EP2 (AH6809), and EP4 receptor (AH23848)]...
  79. doi Role of EP4 receptor and prostaglandin transporter in prostaglandin E2-induced alteration in colonic epithelial barrier integrity
    Manigandan Lejeune
    Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    Am J Physiol Gastrointest Liver Physiol 299:G1097-105. 2010
    ..PGE(2) couples to and signals via four different E-prostanoid (EP) receptors, namely EP1, EP2, EP3, and EP4...
  80. doi Prostaglandin EP2 receptor signalling inhibits the expression of matrix metalloproteinase 13 in human osteoarthritic chondrocytes
    Tomoo Sato
    Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan
    Ann Rheum Dis 70:221-6. 2011
    ..This study focused on 114 genes that are differentially expressed between intact and damaged osteoarthritis cartilage, in order to determine which molecules are involved in suppressing MMP-13 expression...
  81. doi Troxerutin protects the mouse kidney from d-galactose-caused injury through anti-inflammation and anti-oxidation
    Shao hua Fan
    Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Xuzhou Normal University, Xuzhou 221116, PR China
    Int Immunopharmacol 9:91-6. 2009
    ..NF-kappaB), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and prostanoid receptor subtype EP2 by Western blot. After treatment with D-gal, the NF-kappaB p65, iNOS, COX-2 and EP2 were markedly upregulated...
  82. ncbi Prostaglandin E2 strongly inhibits human osteoclast formation
    Ikuko Take
    Graduate School of Oral Medicine, Matsumoto Dental University, Nagano, Japan
    Endocrinology 146:5204-14. 2005
    ..CD14(+) cells expressed EP2 and EP4, but not EP1 or EP3, whereas CD14(+) cell-derived osteoclasts expressed none of the PGE(2) receptors...
  83. pmc Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor
    Li Yang
    Department of Medicine, The Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Invest 111:727-35. 2003
    ..We characterized the contribution of the PGE(2) EP2 receptor to cancer-associated immune deficiency using EP2(-/-) mice...
  84. doi Differential regulation of airway smooth muscle cell migration by E-prostanoid receptor subtypes
    Hiromichi Aso
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Am J Respir Cell Mol Biol 48:322-9. 2013
    ..PDGF-BB-induced cell migration was inhibited by PGE2, the specific EP2 agonist ONO-AE1-259-01, the specific EP4 agonist ONO-AE1-329, and cAMP-mobilizing agents...
  85. pmc Angiotensin II-dependent phosphorylation at Ser11/Ser18 and Ser938 shifts the E2 conformations of rat kidney Na+/K+-ATPase
    Katherine J Massey
    Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Biochem J 443:249-58. 2012
    ..Ang II increased the initial rate and slowed the second phase in α-1.wild-type, but not α-1.S938A, cells. Thus Ang II changes the conformation of two forms of EP2 via differential phosphorylation.
  86. ncbi Human granulosa-lutein cells express functional EP1 and EP2 prostaglandin receptors
    T E Harris
    Reproduction and Development Group, Department of Veterinary Basic Sciences, Royal Veterinary College, London, NW1 0TU, United Kingdom
    Biochem Biophys Res Commun 285:1089-94. 2001
    ..acts via specific PGE(2) receptor subtypes including EP1, which modulates intracellular calcium ([Ca(2+)](i)) and EP2, which is coupled to cyclic AMP (cAMP) generation...
  87. ncbi Epididymal specificity and androgen regulation of rat EP2
    N M Ibrahim
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Reprod 65:575-80. 2001
    In primates, expression of the EP2 gene is androgen-dependent and epididymis-specific. EP2 mRNA expression was investigated in caput, corpus, and cauda regions of rat epididymis and in 15 other rat tissues...
  88. doi α-Tocopherol (vitamin E) stimulates cyclic AMP production in human peripheral mononuclear cells and alters immune function
    Sonemany Salinthone
    Department of Veterans Affairs Medical Center, VA Medical Center, Portland, OR 97239, USA
    Mol Immunol 53:173-8. 2013
    ..Inhibitor studies demonstrate that the prostaglandin EP2 and EP4 receptors and adenylyl cyclases mediate the effects of α-tocopherol on cAMP production...
  89. doi Prostaglandin E2 functions as a luteotrophic factor in the dog
    Mariusz P Kowalewski
    Vetsuisse Faculty, Institute of Veterinary Anatomy, University of Zurich, Zurich, Switzerland
    Reproduction 145:213-26. 2013
    ..and mid-gestation periods of pregnancy and during luteolysis; the luteal expression of PGE2 receptors (EP2 and EP4) has been investigated at the protein level throughout pregnancy...
  90. doi Significance of divergent expression of prostaglandin EP4 and EP3 receptors in human prostate cancer
    Hosea F S Huang
    Division of Urology, UMDNJ New Jersey Medical School, University Hospital, Newark, New Jersey 07103, USA
    Mol Cancer Res 11:427-39. 2013
    ..specimens were evaluated by immunohistochemistry (IHC) and Western blotting for the expression of EP1, EP2, EP3, and EP4...
  91. doi Mesenchymal stem cells reprogram host macrophages to attenuate obliterative bronchiolitis in murine orthotopic tracheal transplantation
    Zhixiang Guo
    Department of Cardiovascular and Thoracic Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China
    Int Immunopharmacol 15:726-34. 2013
    ..Mechanistically, MSCs-derived PGE2, through the receptors EP2 and EP4, promoted the release of IL-10 and inhibited the production of IL-6 and TNF-α by macrophages...
  92. doi Boar sperm cryosurvival is better after exposure to seminal plasma from selected fractions than to those from entire ejaculate
    Diego V Alkmin
    Department of Medicine and Animal Surgery, University of Murcia, Murcia, Spain
    Cryobiology 69:203-10. 2014
    ..epididymal sperm samples from the same 10 boars were collected post-mortem and extended in SP from P1 (EP1), P2 (EP2) and post SRF (EP3), and also held 24h before freezing for a better understanding of the influence of SP on boar ..
  93. pmc Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling
    Zbigniew Zaslona
    Divisions of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
    Blood 119:2358-67. 2012
    ..Macrophage maturation was studied in vitro in bone marrow cell cultures, and in vivo in a model of peritonitis. EP2 was the most abundant PGE(2) receptor expressed by bone marrow cells, and its expression further increased during ..
  94. pmc PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis
    Ryosuke Tsutsumi
    Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Bone Miner Res 24:1753-62. 2009
    ..However, the PGE2 receptor (EP1, EP2, or EP4), and cell type in which it is expressed, which is responsible for PGE2 induction of RANKL during wear ..
  95. ncbi Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes
    Y Boie
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe Claire Dorval, Que, Canada
    Eur J Pharmacol 340:227-41. 1997
    We have characterized the rat prostanoid EP1, EP2, EP3alpha and EP4 receptor subtypes cloned from spleen, hepatocyte and/or kidney cDNA libraries...
  96. pmc Epoxyeicosatrienoic acids affect electrolyte transport in renal tubular epithelial cells: dependence on cyclooxygenase and cell polarity
    Rolf M Nusing
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Am J Physiol Renal Physiol 293:F288-98. 2007
    ..Although the presence of the PGE(2) receptors EP2, EP3, and EP4 was demonstrated, apically added PGE(2) was ineffective and basolaterally added PGE(2) caused a ..
  97. doi Prostaglandin E2 contributes to the synthesis of brain-derived neurotrophic factor in primary sensory neuron in ganglion explant cultures and in a neuropathic pain model
    Pedro Cruz Duarte
    Douglas Mental Health University Institute, Quebec, Canada H4H 1R3
    Exp Neurol 234:466-81. 2012
    ..BDNF is mainly co-expressed with the EP1 and EP4 while moderately with the EP2 and EP3 receptor subtypes in naïve and PSNL rats...
  98. doi The mRNA expression of prostaglandin E receptors EP2 and EP4 and the changes in glycosaminoglycans in the sheep cervix during the estrous cycle
    C M Kershaw-Young
    Department of Veterinary Clinical Sciences, The Royal Veterinary College, North Mymms, Hatfield, Hertfordshire, United Kingdom
    Theriogenology 72:251-61. 2009
    ..We propose that prostaglandin E(2) binds to EP(2) and EP(4) stimulating hyaluronan synthesis, which may cause remodeling of the cervical extracellular matrix, culminating in cervical relaxation...
  99. doi A regulatory cross-talk between Vgamma9Vdelta2 T lymphocytes and mesenchymal stem cells
    Ludovic Martinet
    INSERM, U 563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    Eur J Immunol 39:752-62. 2009
    ..This inhibition was mediated by the COX-2-dependent production of prostaglandin E2 (PGE(2)) and by MSC through EP2 and EP4 inhibitory receptors expressed by Vgamma9Vdelta2 T lymphocytes...
  100. ncbi 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway
    Yin Tintut
    Department of Medicine, School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 277:14221-6. 2002
    ..Receptor antagonist studies suggest that isoPGE2 effects were mediated by prostaglandin receptor subtypes EP2/DP on preosteoclasts and subtype EP1 and thromboxane receptors on stromal/osteoblast cells...
  101. pmc Seeing red: flushing out instigators of niacin-associated skin toxicity
    Richard L Dunbar
    Department of Medicine, Division of Experimental Therapeutics, Institute for Translational Medicine and Therapeutics, Pennsylvania 19104, USA
    J Clin Invest 120:2651-5. 2010
    ..paradigm in showing that the major player in vasodilation is the keratinocyte, which produces PGE2, stimulating EP2/4 receptors, shifting the role of the Langerhans/PGD2/DP1 pathway to that of an accomplice...

Research Grants63

  1. CYCLOOXYGENASE AND TUMORIGENESIS
    Daniel Hwang; Fiscal Year: 2003
    ..cells as compared with normal cells and to identify downstream signaling pathways of prostaglandin E receptor (Ep2)...
  2. IL-1nduced Mediators of CNS Inflammation and AD: PGE
    MICHAEL O BANION; Fiscal Year: 2006
    ..the influence of IL-1a on cell and tissue responses to PGE2, initially focusing on regulation and actions of the EP2 subtype of PGE2 receptor...
  3. Prostaglandin signaling following seizures
    Jianxiong Jiang; Fiscal Year: 2013
    ..pursued two major avenues of research 1) to develop small molecules that selectively modify prostaglandin receptor EP2, and 2) to determine how these compounds affect the pathologies in mouse models of epilepsy...
  4. Role of Prostaglandin Receptors in Stroke
    SYLVAIN DORE; Fiscal Year: 2013
    ..our current working hypothesis is that PGE2 EP1 and EP3 receptors would promote ICH acute injury, whereas EP2 and EP4 receptors would promote neuroprotection after ICH...
  5. Eicosanoid Balance in Lung Transplant Injury and Repair
    David Pinsky; Fiscal Year: 2009
    ..balance in BO development following second hit (ischemic, viral) injury, use genetic (COX, prostanoid receptor [EP2], and 5-LO deficient) and pharmacologic (COX and 5-LO inhibitor, LT receptor antagonist) strategies...
  6. Role of COX2 of Neuronal Origin in Blood-Brain Communication after status epilept
    Raymond J Dingledine; Fiscal Year: 2012
    ..leukocyte infiltration, microglial activation, and eventually epilepsy;and (2) To test the hypothesis that EP2 receptor activation on astrocytes or endothelial cells regulates albumin leakage and leukocyte infiltration across ..
  7. EICOSANOIDS AND LUNG MACROPHAGE ANTIMICROBIAL MECHANISMS
    MARC L PETERS-GOLDEN; Fiscal Year: 2012
    ..1 [BLT1]) and LTD4 (via cysteinyl LT receptor 1 [cysLT1]) promote, while PGE2 (via E prostanoid receptors 2 and 4 [EP2 and EP4]) inhibits, AM capacity for phagocytosis and killing of IgG-opsonized microbes...
  8. Prostanoid signaling and inflammation in aging and Alzheimer's disease
    Katrin I Andreasson; Fiscal Year: 2013
    ..In recent studies, we have identified a central function of PGE2 signaling through its EP2 receptor in mediating inflammation, oxidative stress, and neurotoxicity...
  9. Cyclooxygenase-2 Induced Pancreatic Cancer
    Susan M Fischer; Fiscal Year: 2012
    ..The major prostaglandin (PG) product, PGE2, binds to one or more of the 4 EP receptors. EP2 and EP4 are linked to adenylate cyclase causing an increase in cAMP and subsequent activation of protein kinase A (..
  10. Regulation of PAF Acetylhydrolase Expression by Oxidized Phospholipids
    SUZANNE BARBOUR; Fiscal Year: 2009
    ..We hypothesize that long chain, prostaglandin-like oxPL induce PAFAH by binding to the CD14/ TLR4 complex and the EP2 prostaglandin receptor on dendritic cells in the developing atherosclerotic lesion...
  11. Cellular and Molecular Mechanisms of Inflammation in Alzheimer's Disease
    Nathaniel S Woodling; Fiscal Year: 2012
    ..Downstream of prostaglandin production, the PGE2 EP2 receptor may be a more specific molecular target in the search for strategies that prevent and reduce inflammation ..
  12. Role of COX-2 in UVB-induced beta-catenin signaling in keratinocytes
    Jill C Pelling; Fiscal Year: 2011
    ..primary mouse and human keratinocytes, as well as in mouse epidermis in vivo using COX-2+/- heterozygote mice and EP2-/- knockout mice and in human skin tumor samples...
  13. REGULATION OF PROSTAGLANDIN RECEPTORS IN MYOMETRIUM
    Leslie Myatt; Fiscal Year: 2006
    ..1) to study mRNA and protein expression and localization for contractile FPI, EP1, EP3, and TP and relaxatory IP, EP2, and EP4 receptors in pregnant rat myometrium (day 16 to one day postpartum) and in pregnant animals with hormonal ..
  14. Tpl2 in Carcinogenesis-Related Inflammation
    KATHLEEN LEIGH DECICCO-SKINNER; Fiscal Year: 2011
    ..PGE2 binds to one of four G-protein linked receptors designated EP1, EP2, EP3, and EP4...
  15. CYCLOOXYGENASE AND PGE2 RECEPTOR FUNCTION IN SKIN CANCER
    Alice Pentland; Fiscal Year: 2004
    ..Our preliminary work demonstrates that primary human keratinocytes express both growth-stipulatory (EP2) and growth- inhibitory (EP3) receptors for prostaglandin E2 (PGE2) in significant amounts...
  16. MOLECULAR BASIS OF PRECONDITIONING
    Yiru Guo; Fiscal Year: 2005
    ..will be systematically interrogated by targeted genetic disruption of all known prostaglandin receptors (DP, EP1, EP2, EP3, EP4, F, and IP receptors)...
  17. Lipoic Acid Therapy for Experimental Autoimmune Encephalomyelitis
    DENNIS NEIL BOURDETTE; Fiscal Year: 2013
    ..the production of the small second molecule messenger cAMP via the prostaglandin G-coupled protein receptors EP2 and EP4...
  18. Chemopreventive effect of fish oil derived EPA in lung cancer
    Peiying Yang; Fiscal Year: 2013
    ..using the urethane-induced mouse lung cancer model with or without expression of EP receptor, particularly EP2 and EP4 receptors, will be further studied...
  19. PROSTANOIDS IN COLON CANCER--CELL/MOLECULAR MECHANISMS
    James Roche; Fiscal Year: 1999
    ..now allow these issues to be addressed: 1) Procurement of sequence information/cloning of receptors for prostanoids EP2, EP3, EP4, IP, FP and TP; 2) A cDNA clone for a second (inducible) cyclo- oxygenase with potential importance in ..
  20. N-3 Fatty Acid-Induced Akt Suppression: Chemoprevention for Pancreatic Neoplasia
    PAUL JOSEPH GRIPPO; Fiscal Year: 2013
    ..and during disease progression along with specific molecular events (activation of Akt, effects of PGE3-bound EP2 on Akt activation, phosphorylation of various proteins like Akt, Foxo, and Bad,) will determine the mechanisms of ..
  21. HSCT-induced changes that impair lung innate immunity
    Bethany B Moore; Fiscal Year: 2012
    ..AMs from human HSCT patients overexpress COX-2 and PGE2 and have altered scavenger receptor profiles, the mechanisms by which this occurs and to test the therapeutic effect of cyclooxygenase or EP2 inhibition on innate immune function.
  22. High Fat Feeding Promotes Malfunction of the Nodose Ganglia
    Chung Owyang; Fiscal Year: 2013
    ..these abnormalities may be prevented by blockade of Toll-like receptor 4 signaling pathway or administration of EP2 receptor inhibitor, suggesting medication by prostaglandin evoked by LPS...
  23. Mechanisms for Dysfunctional HDL Formation in Familial Hypercholesterolemia
    Macrae F Linton; Fiscal Year: 2013
    ..receptors implicated in atherogenesis, including receptors for thromboxane (TP) and prostaglandin (PG)E2 (EP2)...
  24. Prostaglandin E2 Signaling in Growth and Pains of Endometriosis
    Joe A Arosh; Fiscal Year: 2012
    ..PGE2 produced at the site of inflammation acts on the nociceptors of peripheral terminals through EP1, EP2, EP3, and EP4 receptors by integrating multiple cell signaling pathways...
  25. PROSTANOID MEDIATED CYOPROTECTION
    Serrine Lau; Fiscal Year: 2001
    ..The cellular effects of PGE are receptor mediated and four PGE receptors (EP) have been identified and termed EP 1, EP2, EP3, and EP4...
  26. EP2 Allosteric Potentiators for Subarachnoid Hemorrhage
    Raymond J Dingledine; Fiscal Year: 2012
    ..b>EP2 receptor activation has been shown to be neuroprotective in several animal models of acute cerebral ischemia...
  27. Development of a Novel Atmospheric Pressure Glow Discharge for Ambient Mass Spect
    JUSTIN MICHAEL WISEMAN; Fiscal Year: 2011
    ..Optical spectroscopy measurement revealed novel species (He2+), which are implicated in the ionization mechanism...
  28. The inflammatory role of the platelet in aspirin-exacerbated respiratory disease.
    TANYA MARIA LAIDLAW; Fiscal Year: 2013
    ..that platelets from individuals with AERD demonstrate decreased function of two prostaglandin E2 receptors, EP2 and EP4, which lowers the threshold for activation of their platelets and allows for increased platelet adhesion ..
  29. Mouse Models of Eosinophil-Associated Lung Dysfunction
    Nancy A Lee; Fiscal Year: 2013
    ..e., degranulation)). These limitations have led us to create an allergen- naive double transgenic mouse (I5/hE2) that expresses IL-5 systemically from mature T cells and eotaxin-2 locally from lung epithelial cells...
  30. Modulating Neuroinflammation via PGE2 signaling in models of Parkinsonism
    SURAJ SUNIL PRADHAN; Fiscal Year: 2013
    ..prostaglandin E2 (PGE2) can regulate innate immune responses in the brain via the pro- inflammatory receptor EP2 and anti-inflammatory receptor EP4...
  31. Molecular Basis of Treating Endometriosis by Prostaglandin E2 Receptor Inhibitors
    Joe A Arosh; Fiscal Year: 2012
    ..Our central hypothesis is that loss-of-function of PGE2 receptors EP2 and EP4 inhibits survival and growth of endometriosis...
  32. Development of a Novel Atmospheric Pressure Glow Discharge for Ambient Mass Spect
    JUSTIN MICHAEL WISEMAN; Fiscal Year: 2012
    ..Optical spectroscopy measurement revealed novel species (He2+), which are implicated in the ionization mechanism...
  33. E-Prostanoid Receptor Subtype 2 (EP2) Regulation of Microglial Activation
    Patrick J Cimino; Fiscal Year: 2011
    ..Recently we demonstrated that genetic ablation of the EP2 receptor from primary mouse microglia resulted in the highly desirable dual phenotype of an increase in ..
  34. Novel EP receptor antagonists for the treatment of hypertension and of diabetes
    Richard M Breyer; Fiscal Year: 2013
    ..Our working hypothesis is that blockade of both the EP1 and EP3 receptors while leaving the EP2 and EP4 receptor response intact will be protective in settings of renal disease and may be more beneficial than ..
  35. Epigenetic Regulation of the E Prostanoid 2 Receptor Gene in Lung Fibroblasts
    Steven K Huang; Fiscal Year: 2013
    ..What is unclear is how EP2 expression is lost in these cells...
  36. Effects of PGE2 on reconstitution of hematopoiesis and immunity after UCBT
    Corey S Cutler; Fiscal Year: 2013
    ..In UCB T cells PGE2 modified the Wnt signaling cascade through EP2/EP4 receptors and cAMP-mediated phosphorylation of Gsk3, resulting in stabilization of [unreadable]-catenin and TCF-..
  37. PG's and Keratinocyte Adhesion
    Sabine M Brouxhon; Fiscal Year: 2013
    ..Moreover, the candidate has discovered that this process is regulated by activation of the EP2 receptor by PGE2 released locally after UV radiation injury...
  38. Eicosanoid Networks in Aspirin Exacerbated Respiratory Disease
    Joshua A Boyce; Fiscal Year: 2013
    ..These abnormalities result in failure of the prostaglandin (PG)E2-EP2 receptor system to control the synthesis and effector actions of cysteinyl leukotrienes (cys-LTs)...
  39. The role of E-cadherin in photocarcinogenesis
    Sabine M Brouxhon; Fiscal Year: 2010
    ..since we recently demonstrated that inhibition of PGE2 synthesis by indomethacin in vitro, targeted deletion of EP2 in primary mouse keratinocyte (PMK) cultures or deletion of the EP2 receptor in vivo or in vitro abrogated this UV-..
  40. Role of PGE2 receptors in the aging brain after intracerebral hemorrhage
    Jian Wang; Fiscal Year: 2012
    ..We hypothesize that PGE2 EP1 and EPS receptors promote acute brain injury, whereas EP2 and EP4 receptors promote neuroprotection after ICH. Three specific aims will test our hypothesis...
  41. The Role of COX2 in the Progression of Calcific Aortic Valve Disease
    ELAINE EMILY WIRRIG; Fiscal Year: 2013
    ..In bone, COX2 catalyzes the first committed step in the synthesis of prostaglandin E2, which signals via the EP2 receptor to phosphorylate p-38 MAPK, which subsequently activates an osteogenic pathway necessary for new bone ..
  42. Prostanoid Modulators that Reduce Brain Injury After Seizures
    Raymond J Dingledine; Fiscal Year: 2013
    ..We have evidence that activation of brain EP2 receptors can be neuroprotective after status epilepticus...
  43. Pathophysiologic and therapeutic mechanisms of aspirin exacerbated respiratory d*
    Joshua A Boyce; Fiscal Year: 2013
    ..We have also found that platelets and leukocytes from individuals with AERD lack the EP2 receptor for PGE2...
  44. Molecular Mechanism of PGE2 Receptor Pressor Effects
    Richard M Breyer; Fiscal Year: 2011
    ..The EP1 and EP3 receptors primarily mediate the pressor response, while the EP2 and EP4 receptors mediate the depressor response...
  45. Astatine 211 & Radioiodine Labeled Octreotide Conjugates
    Michael Zalutsky; Fiscal Year: 2004
    ..Our specific aims are: 1) To synthesizL he2' 'At-labeled octreotide analogues [N-(3-[211 At]astatobenzoyl)-D-phe1]octreotide and 5[211 'At]astato-nicotinoylD-..
  46. PROSTAGLANDINS AND GASTROINTESTINAL DNA DAMAGE
    Courtney Houchen; Fiscal Year: 2006
    ..The EP receptors are encoded by four separate genes (EP1, EP2, EP3 and EP4). These receptors differ in their ligand binding specificity and in down stream signaling pathways...
  47. Adenylyl cyclases in airway and GI smooth muscle
    Rennolds S Ostrom; Fiscal Year: 2010
    ..cAMP formation and relaxation but not increased basal cAMP levels or response to activation of prostaglandin EP2 receptors...
  48. ROLE OF PGE2 RECEPTORS EP2 AND EP3 ON SENESCENCE
    Raymond Konger; Fiscal Year: 2004
    Growth stimulation by EP2 receptors is dependent on ligand- dependent activation of adenylate cyclase, with elevation of cyclic adenosine monophosphate (cAMP)...
  49. REGULATED POLYADENYLATION OF MESSENGER RNA
    Daniel Schoenberg; Fiscal Year: 2004
    ..with PLE like elements and this investigator demonstrated the functionality of the PLE in the gene encoding the HIV-EP2/Schnurri 2, a zinc finger transcription factor that activates transcription of the integrated HIV-1 provirus...
  50. ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATA
    Serdar Bulun; Fiscal Year: 2007
    ..We will test the hypothesis that PGE2 acts via EP1 and EP2 receptor subtypes to stimulate both PKC and PKA pathways, which induce P450arom expression...
  51. PGE2 in the Pathogenesis of Allergic Airway Disease
    Beverly Koller; Fiscal Year: 2009
    ..we showed that activation of the EP1 and EP3 receptors by PGE2 leads to airway obstruction, while activation of the EP2 receptor protected against methacholine-induced bronchoconstriction...
  52. Genetic Study of Prostaglandin Synthesis/EGFR and Risk of Colorectal Neoplasia
    Cornelia Ulrich; Fiscal Year: 2007
    ..PGES) and 15- hydroxyprostaglandin dehydrogenase (PGDN); b) bind to PGE2 at the cell surface (receptors EP1, EP2, and EP4); or c) are involved in PGE2 cross-talk with EGFR signaling (Src and EGFR)...
  53. MEDIATORS OF INFLAMMATION IN INFLAMMATORY BOWEL DISEASE
    WILLIAM STENSON; Fiscal Year: 2006
    ..have developed data suggesting that the effects of PGE2 on these events in mice are mediated through binding to the EP2 receptor...
  54. PULMONARY C-NEURON HYPERSENSITIVITY:CELLULAR MECHANISMS
    Lu Yuan Lee; Fiscal Year: 2005
    ..of this study is that endogenous PGE2 increases the sensitivity of the pulmonary C-fiber endings by activating EP2 and/or EP4 prostanoid receptors; activation of these EP receptors enhances the neuronal excitability by activating ..
  55. Modulation of Lung Innate Immunity Prostaglandin E2
    David Aronoff; Fiscal Year: 2009
    ..effects changes in cell functions through ligation of four distinct G-protein coupled E-prostanoid receptors (EP1, EP2, EP3 and EP4)...
  56. PROSTAGLANDIN E2 RECEPTORS IN GASTROINTESTINAL INJURY
    Courtney Houchen; Fiscal Year: 2004
    ..The EP receptors are encoded by four separate genes (EPI, EP2, EP3, and EP4 )...
  57. Functional Analysis of the Prostaglandin EP3 Receptor
    Richard Breyer; Fiscal Year: 2005
    ..of PGE2's effects are mediated via specific guanine nucleotide regulatory protein coupled receptors designated EP1, EP2, EP3, and EP4...
  58. Lipid Oxidation Products in Alzheimer's Disease
    Thomas Montine; Fiscal Year: 2007
    ..abstract_text> ..
  59. Characterization of Dementia with Lewy Bodies: A Collaborative Study
    Thomas Montine; Fiscal Year: 2007
    ..This resource will be made available for future investigations of DLB. ..
  60. ROLE OF PROTEIN KINASES IN TRANSPORT REGULATION
    Mary Taub; Fiscal Year: 2004
    ..The possible involvement of an inhibitory phosphatase, in regulating the phosphorylation of the Na,K-ATPase will also be examined. ..
  61. CATECHOL THIOETHERS IN PARKINSON'S DISEASE
    Thomas Montine; Fiscal Year: 2004
    ....
  62. Proteomic Discovery in Parkinson-Dementia Complex of Guam
    Thomas Montine; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  63. LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASE
    Thomas Montine; Fiscal Year: 2003
    ..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..