SP6

Summary

Gene Symbol: SP6
Description: Sp6 transcription factor
Alias: EPFN, EPIPROFIN, KLF14, transcription factor Sp6, Kruppel-like factor 14, krueppel-like factor 14
Species: human
Products:     SP6

Top Publications

  1. Yang M, Lin X, Rowe A, Rognes T, Eide L, Bjørås M. Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway. Sci Rep. 2015;5:17409 pubmed publisher
    ..These differentially expressed genes include transcription factors (i.e. HIF1A, SP6, E2F8 and TCF3), antioxidant genes (PRDX4, PTGS1 and CYGB) and numerous genes of the p53 signaling pathway involved ..
  2. Nakamura T, Chiba Y, Naruse M, Saito K, Harada H, Fukumoto S. Globoside accelerates the differentiation of dental epithelial cells into ameloblasts. Int J Oral Sci. 2016;8:205-212 pubmed publisher
    ..Furthermore, Gb4 induced the expression of epiprofin and Runx2, the positive regulators for ameloblastin gene transcription...
  3. Lee S, Luong R, Johnson D, Cunha G, Rivina L, Gonzalgo M, et al. Androgen signaling is a confounding factor for β-catenin-mediated prostate tumorigenesis. Oncogene. 2016;35:702-14 pubmed publisher
    ..profiles showed more robust enrichment of known tumor- and metastasis-promoting genes: Spp1, Egr1, c-Myc, Sp5, and Sp6 genes, in samples isolated from Ctnnb1(L(ex3)/+)/R26hAR(L/+):PB-Cre4 compound mice than those from Ctnnb1(L(ex3)/+):..
  4. Beverly M, Hagen C, Slack O. Poly A tail length analysis of in vitro transcribed mRNA by LC-MS. Anal Bioanal Chem. 2018;410:1667-1677 pubmed publisher
    ..The type of RNAP did not alter the observed tail distribution, and comparison of T3, T7, and SP6 showed all three RNAPs produced equivalent tail length distributions...
  5. Liang R, Li P, Peng X, Xu L, Fan P, Peng J, et al. Efficacy of acupuncture on pelvic pain in patients with endometriosis: study protocol for a randomized, single-blind, multi-center, placebo-controlled trial. Trials. 2018;19:314 pubmed publisher
    ..assigned to the treatment group will be treated with acupuncture treatment at Guanyuan (CV4), Sanyinjiao (SP6), Taichong (LR3), Zhaohai (KI6) and Qichong (ST30) while the control group will receive acupuncture at non-..
  6. Cserni G. Analysis of membranous Ki-67 staining in breast cancer and surrounding breast epithelium. Virchows Arch. 2018;473:145-153 pubmed publisher
    ..tested, greater dilution of the primary antibody did not abolish the membranous staining, which was absent with the SP6 monoclonal Ki-67 antibody...
  7. Civelek M, Wu Y, Pan C, Raulerson C, Ko A, He A, et al. Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits. Am J Hum Genet. 2017;100:428-443 pubmed publisher
    ..These trans-eQTL signals confirmed and extended the previously reported KLF14-mediated network to 55 target genes, validated the CIITA regulation of class II MHC genes, and identified ZNF800 ..
  8. Orílio A, Fortes I, Navas Castillo J. Infectious cDNA clones of the crinivirus Tomato chlorosis virus are competent for systemic plant infection and whitefly-transmission. Virology. 2014;464-465:365-374 pubmed publisher
    ..We present the construction of full-length cDNA clones of the ToCV genome (RNA1 and RNA2) fused to the SP6 RNA polymerase promoter and under the control of the CaMV 35S promoter...
  9. Aroxa F, Gondim I, Santos E, Coriolano M, Asano A, Asano N. Acupuncture as Adjuvant Therapy for Sleep Disorders in Parkinson's Disease. J Acupunct Meridian Stud. 2017;10:33-38 pubmed publisher
    ..The control group had no intervention. The intervention was executed using the acupuncture points LR3 (Taichong), SP6 (Sanyinjiao), LI4 (Hegu), TE5 (Wai-Guan), HT7 (Shenmen), PC6 (Neiguan), LI11 (Quchi), GB20 (Fengchi)...

More Information

Publications116 found, 100 shown here

  1. Lyssenko V, Groop L, Prasad R. Genetics of Type 2 Diabetes: It Matters From Which Parent We Inherit the Risk. Rev Diabet Stud. 2015;12:233-42 pubmed publisher
    ..Such PoO transmission is seen for variants in the KLF14, KCNQ1, GRB10, TCF7L2, THADA, and PEG3 genes...
  2. Dziewulska A, Dobosz A, Dobrzyn A. High-Throughput Approaches onto Uncover (Epi)Genomic Architecture of Type 2 Diabetes. Genes (Basel). 2018;9: pubmed publisher
    ..regions were found in TCF7L2, THADA, KCNQ1, TXNIP, SOCS3, SREBF1, and KLF14 loci that are related to T2D...
  3. Focke C, Burger H, van Diest P, Finsterbusch K, Gläser D, Korsching E, et al. Interlaboratory variability of Ki67 staining in breast cancer. Eur J Cancer. 2017;84:219-227 pubmed publisher
    ..0001). The differences remained significant when labs using the same antibody (MIB-1, SP6, or 30-9) were analysed separately or labs without prior participation in external quality assurance programs were ..
  4. Li T, Wu H, Soto Aguliar F, Huang L, Li W, Lao L, et al. Efficacy of electrical acupuncture on vascular cognitive impairment with no dementia: study protocol for a randomized controlled trial. Trials. 2018;19:52 pubmed publisher
    ..sessions in total), with the same acupoint prescription (DU20, EX-HN3, DU24, DU17, DU26, EX-HN1, HT7, PC6, GB20, SP6). The primary assessment is the Montreal Cognitive Assessment...
  5. Lorenz K, Voight B. Dissecting an adiposity locus with an arsenal of genomics. Genome Biol. 2018;19:74 pubmed publisher
    ..and validated the link between a type-2 diabetes (T2D) association and human adipose biology by means of KLF14 gene expression...
  6. Xiao J, Yi W, Wu L. Effects of electroacupuncture on reducing labor pain and complications in the labor analgesia process of combined spinal-epidural analgesia with patient-controlled epidural analgesia. Arch Gynecol Obstet. 2019;299:123-128 pubmed publisher
    ..Group 1 was first operated CSEA and PCEA, then EA at Hegu (LI4), Neiguan (PC6), Zusanli (ST36) and Sanyinjiao (SP6) by HANS-200A device for 25 min. Group 2 was only treated by CSEA and PCEA...
  7. Chiba Y, He B, Yoshizaki K, Rhodes C, Ishijima M, Bleck C, et al. The transcription factor AmeloD stimulates epithelial cell motility essential for tooth morphology. J Biol Chem. 2019;294:3406-3418 pubmed publisher
    ..Knockout of epiprofin (Epfn), another transcription factor required for tooth morphogenesis and development, and analysis of AmeloD ..
  8. Zhang Y, Jia R, Wang J, Xu X, Yao Y, Ge S, et al. Targeted silencing of MART-1 gene expression by RNA interference enhances the migration ability of uveal melanoma cells. Int J Mol Sci. 2013;14:15092-104 pubmed publisher
    ..In the present study, the UM cell line SP6.5, which showed a high level of MART-1 expression, was subjected to small interfering RNA-mediated silencing of ..
  9. Hanson R, Guo T, Muller Y, Fleming J, Knowler W, Kobes S, et al. Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians. Diabetes. 2013;62:2984-91 pubmed publisher
    ..in an Icelandic population for several genetic variants associated with type 2 diabetes, including those in KLF14 (rs4731702), MOB2 (rs2334499), and KCNQ1 (rs2237892, rs231362)...
  10. Ma W, Bai W, Lin C, Zhou P, Xia L, Zhao C, et al. Effects of Sanyinjiao (SP6) with electroacupuncture on labour pain in women during labour. Complement Ther Med. 2011;19 Suppl 1:S13-8 pubmed publisher
    To evaluate the effects of Sanyinjiao (SP6) with electroacupuncture on labour pain in women during the labour process...
  11. Nishitani Y, Yoshida S, Fujihashi M, Kitagawa K, Doi T, Atomi H, et al. Structure-based catalytic optimization of a type III Rubisco from a hyperthermophile. J Biol Chem. 2010;285:39339-47 pubmed publisher
    ..found that replacement of the entire α-helix 6 of Tk-Rubisco with the corresponding region of the spinach enzyme (SP6 mutant) results in an improvement of catalytic performance at mesophilic temperatures, both in vivo and in vitro, ..
  12. Born Y, Knecht L, Eigenmann M, Bolliger M, Klumpp J, Fieseler L. A major-capsid-protein-based multiplex PCR assay for rapid identification of selected virulent bacteriophage types. Arch Virol. 2019;164:819-830 pubmed publisher
    ..MCP) as a phylogenetic marker, we designed degenerate primers for the identification of Felix O1-, GJ1-, N4-, SP6-, T4-, T7-, and Vi1-like phages in multiplex PCR setups with single phage plaques as templates...
  13. Nielsen T, Sparsø T, Grarup N, Jørgensen T, Pisinger C, Witte D, et al. Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release. Diabetologia. 2011;54:1052-6 pubmed publisher
    ..We examined 12 lead variants in or near HMGA2, CENTD2 (also known as ARAP1), KLF14, PRC1, TP53INP1, ZBED3, ZFAND6, CHCHD9, DUSP9, KCNQ1, BCL11A and HNF1A in 5,722 middle-aged people from the ..
  14. Kashefi F, Khajehei M, Ashraf A, Jafari P. The efficacy of acupressure at the Sanyinjiao point in the improvement of women's general health. J Altern Complement Med. 2011;17:1141-7 pubmed publisher
    This study's objective was to examine the effectiveness of Sanyinjiao point (SP6) acupressure on women's general health. This was a randomized, single-blind clinical trial...
  15. Dailey S, Kozmikova I, Somorjai I. Amphioxus Sp5 is a member of a conserved Specificity Protein complement and is modulated by Wnt/β-catenin signalling. Int J Dev Biol. 2017;61:723-732 pubmed publisher
    A cluster of three Specificity Protein (Sp) genes (Sp1-4, Sp5 and Sp6-9) is thought to be ancestral in both chordates and the wider Eumetazoa...
  16. Chen X, Tan Q, Wang Y, Lv H, Wang Z, Lin Z, et al. Overexpression of KLF14 protects against immune-mediated hepatic injury in mice. Lab Invest. 2019;99:37-47 pubmed publisher
    ..Krüppel-like factors (KLFs) regulate a broad of cellular processes including immunocyte maturation. KLF14 may regulate Treg differentiation, but the biological functions remain far from elucidated...
  17. Wezyk M, Spolnicka M, Pośpiech E, Pepłońska B, Zbieć Piekarska R, Ilkowski J, et al. Hypermethylation of TRIM59 and KLF14 Influences Cell Death Signaling in Familial Alzheimer's Disease. Oxid Med Cell Longev. 2018;2018:6918797 pubmed publisher
    ..Here, we show that the aging-correlated hypermethylation of KLF14 and TRIM59 genes associates with abnormalities in DNA repair and cell cycle control in fEOAD...
  18. Jung S, Lim S, Hong S, Lee E, Shin K, Lee H. DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples. Forensic Sci Int Genet. 2019;38:1-8 pubmed publisher
    ..In this study, DNA methylation at 5 CpG sites from the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes were investigated in 448 samples from blood, saliva, and buccal swabs...
  19. Mauad M, Siri A, Donato M. Does Type of Substratum Affects Chironomid Larvae Assemblage Composition? A Study in a River Catchment in Northern Patagonia, Argentina. Neotrop Entomol. 2017;46:18-28 pubmed publisher
    ..Stictocladius spF, Cricotopus (Paratrichocladius) sp6, Cricotopus sp2, Cricotopus sp3 and Parapsectrocladius sp2 were the most abundant taxa...
  20. Hu W, Lu H, Zhang J, Fan Y, Chang Z, Liang W, et al. Krüppel-like factor 14, a coronary artery disease associated transcription factor, inhibits endothelial inflammation via NF-κB signaling pathway. Atherosclerosis. 2018;278:39-48 pubmed publisher
    Human genetic studies indicated that variations near the transcription factor Krüppel-like factor 14 (KLF14) gene locus are highly associated with coronary artery disease...
  21. Chen H, Wang H, Chiu M, Hu H. Effects of acupressure on menstrual distress and low back pain in dysmenorrheic young adult women: an experimental study. Pain Manag Nurs. 2015;16:188-97 pubmed publisher
    ..group (n = 65) received acupressure massage three times a week for 30 minutes on the sanyinjiao (SP6), ciliao (BL32), and taichong (Liver 3) acupoints...
  22. Alraek T, Baerheim A, Birch S. Acupuncture points used in the prophylaxis against recurrent uncomplicated cystitis, patterns identified and their possible relationship to physiological measurements. Chin J Integr Med. 2016;22:510-7 pubmed publisher
    ..for patients with Kidney (Shen) qi/yang deficiency were Shenshu (BL23), Taixi (KI3), Zhongji (CV3), Sanyinjiao (SP6) and Pangguangshu (BL28), compared with Taichong (LR3), CV3, BL28, Yinlingquan (SP9) and SP6 for Liver (Gan) qi ..
  23. Tang W, Chen W, Yu C, Chang Y, Chen C, Wang C, et al. Effects of acupressure on fatigue of lung cancer patients undergoing chemotherapy: an experimental pilot study. Complement Ther Med. 2014;22:581-91 pubmed publisher
    ..Acupoints were Hegu (LI4), Zusanli (ST36), and Sanyingjiao (SP6). All subjects received acupressure once every morning for 5 months, with each acupoint pressed for 1 min...
  24. Qiu C, Li P, Bi J, Wu Q, Lu L, Qian G, et al. Differential expression of TYRP1 in adult human retinal pigment epithelium and uveal melanoma cells. Oncol Lett. 2016;11:2379-2383 pubmed
    ..expression of TYRP1 was investigated at the mRNA, protein and morphological levels in four human UM cell lines (SP6.5, OM431, OCM1 and OCM290) and the human retinal pigment epithelium (RPE) cell line, using polymerase chain ..
  25. Palacios O, Choix F, Bashan Y, de Bashan L. Influence of tryptophan and indole-3-acetic acid on starch accumulation in the synthetic mutualistic Chlorella sorokiniana-Azospirillum brasilense system under heterotrophic conditions. Res Microbiol. 2016;167:367-79 pubmed publisher
    ..Experiments used two wild-type A. brasilense strains (Cd and Sp6) and an IAA-attenuated mutant (SpM7918) grown under nitrogen-replete and nitrogen-starved conditions tested under ..
  26. Jang D, Jung C, Kim K, Lee J. Electroacupuncture for abdominal pain relief in patients with acute pancreatitis: study protocol for a randomized controlled trial. Trials. 2018;19:279 pubmed publisher
    ..EA includes 12 peripheral acupoints, Zhong Wan (CV12), Shang Wan (CV13), He Gu (LI4), Nei Guan (PC6), San Yin Jiao (SP6), Xuan Zhong (GB39), Zu San Li (ST36), and Shang Ju Xu (ST37)...
  27. Kummerer B. Establishment and Application of Flavivirus Replicons. Adv Exp Med Biol. 2018;1062:165-173 pubmed publisher
    ..will cover strategies for generating flavivirus replicons, including the establishment of bacteriophage (T7 or SP6) promoter-driven constructs as well as cytomegalovirus (CMV) promoter-driven constructs...
  28. Gao K, Wang J, Li L, Zhai Y, Ren Y, You H, et al. Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China. Int J Environ Res Public Health. 2016;13: pubmed publisher
    Genetic variants at KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963 have been associated with type 2 diabetes mellitus (T2DM), but the results are contradictory in Chinese populations...
  29. de Assuncao T, Lomberk G, Cao S, Yaqoob U, Mathison A, Simonetto D, et al. New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. J Biol Chem. 2014;289:15798-809 pubmed publisher
    ..Screening for GC-rich binding transcription factors that could activate this site demonstrated that KLF14, a gene implicated in obesity and the metabolic syndrome, binds to this region...
  30. Naue J, Sänger T, Hoefsloot H, Lutz Bonengel S, Kloosterman A, Verschure P. Proof of concept study of age-dependent DNA methylation markers across different tissues by massive parallel sequencing. Forensic Sci Int Genet. 2018;36:152-159 pubmed publisher
    ..selected age-dependent loci based on whole blood analysis including amongst others ELOVL2, TRIM59, F5, and KLF14 also have predictive value in other forensically relevant tissues...
  31. Yanuaryska R, Miyoshi K, Adiningrat A, Horiguchi T, Tanimura A, Hagita H, et al. Sp6 regulation of Rock1 promoter activity in dental epithelial cells. J Med Invest. 2014;61:306-17 pubmed
    b>Sp6 is a transcription factor of the SP/KLF family and an indispensable regulator of the morphological dynamics of ameloblast differentiation during tooth development. However, the underlying molecular mechanisms remain unclear...
  32. de Carvalho R, Parisi J, Prado W, De Araújo J, Silva A, Silva J, et al. Single or Multiple Electroacupuncture Sessions in Nonspecific Low Back Pain: Are We Low-Responders to Electroacupuncture?. J Acupunct Meridian Stud. 2018;11:54-61 pubmed publisher
    ..After examination (AV0), patients were submitted to EA (2 Hz, 30 minutes, bilaterally at the SP6, BL23, BL31, BL32, BL33, and BL60) and were revaluated after one week (AV1)...
  33. Morris D, Rebelo L, Dieter P, Lee C. Validating intrinsic markers and optimizing spot sampling frequency to estimate fecal outputs. J Dairy Sci. 2018;101:7980-7989 pubmed publisher
    ..Data from individual spot samples were aggregated to represent spot sampling frequencies of 12 (SP12), 6 (SP6), 4 (SP4), or 2 (SP2) evenly spaced events starting at feeding time...
  34. Zhou J, Lin J, Zhang H, Zhu F, Xie R. LncRNA HAND2-AS1 sponging miR-1275 suppresses colorectal cancer progression by upregulating KLF14. Biochem Biophys Res Commun. 2018;503:1848-1853 pubmed publisher
    ..In mechanism, HAND2-AS1 served as a sponge of miR-1275 which targeted KLF14. Through facilitating KLF14 expression, HAND2-AS1 suppressed CRC progression...
  35. Thomer A, Gottschalk M, Christmann A, Naccache F, Jung K, Hewicker Trautwein M, et al. An epistatic effect of KRT25 on SP6 is involved in curly coat in horses. Sci Rep. 2018;8:6374 pubmed publisher
    ..filtered out from whole-genome sequencing data of three curly coated horses of which two variants within KRT25 and SP6 could explain all hair phenotypes...
  36. Haro E, Delgado I, Junco M, Yamada Y, Mansouri A, Oberg K, et al. Sp6 and Sp8 transcription factors control AER formation and dorsal-ventral patterning in limb development. PLoS Genet. 2014;10:e1004468 pubmed publisher
    ..The transcription factors Sp6 and Sp8 are expressed in the limb ectoderm and AER during limb development...
  37. Triyatni M, Berger E, Saunier B. A new model to produce infectious hepatitis C virus without the replication requirement. PLoS Pathog. 2011;7:e1001333 pubmed publisher
    ..a cell-adapted subgenomic replicon, (ii) HCV reporter particles (HCVrp) containing RNA encoding the bacteriophage SP6 RNA polymerase in place of HCV nonstructural genes, and (iii) HCV wild-type particles (HCVwt) containing unmodified ..
  38. Small K, Hedman A, Grundberg E, Nica A, Thorleifsson G, Kong A, et al. Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes. Nat Genet. 2011;43:561-4 pubmed publisher
    ..cis-acting expression quantitative trait locus (eQTL) of the maternally expressed transcription factor KLF14 acts as a master trans regulator of adipose gene expression...
  39. Han K, Kim S, Chung S. Effect of acupuncture on patients with insomnia: study protocol for a randomized controlled trial. Trials. 2014;15:403 pubmed publisher
    ..Five sham acupoints are used in the control group. In the experimental group, five real acupoints (PC6, SP6, HT7, KI6, and BL62) are used unilaterally in turn. Sham acupoints are over 1 cm away from each real acupoint...
  40. Small K, Todorcević M, Civelek M, El Sayed Moustafa J, Wang X, Simon M, et al. Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition. Nat Genet. 2018;50:572-580 pubmed publisher
    ..these associations, we explored the molecular, cellular and whole-body effects of T2D-associated alleles near KLF14. We show that KLF14 diabetes-risk alleles act in adipose tissue to reduce KLF14 expression and modulate, in trans, ..
  41. Li X, Wang Y, Yan B, Fang P, Ma C, Xu N, et al. [Knockdown of STAT3 inhibits proliferation and migration of HepG2 hepatoma cells induced by IFN1]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2018;34:115-122 pubmed
    ..1-sp6-pgk-GFP to construct shRNA-expressing vectors. Along with backbone psPAX2 and pMD2...
  42. Vitali C, Khetarpal S, Rader D. HDL Cholesterol Metabolism and the Risk of CHD: New Insights from Human Genetics. Curr Cardiol Rep. 2017;19:132 pubmed publisher
    ..for selected key HDL-C genes CETP, LCAT, LIPG, SCARB1, and novel loci implicated from GWAS including GALNT2, KLF14, and TTC39B...
  43. Seo S, Moon J, Kang S, Kwon O, Kwon S, Bang S, et al. An estradiol-independent BDNF-NPY cascade is involved in the antidepressant effect of mechanical acupuncture instruments in ovariectomized rats. Sci Rep. 2018;8:5849 pubmed publisher
    ..The animals were divided into Sham OVX, OVX, OVX + Sameumgyo (SP6) and OVX + NonAcu (non-acupuncture point) groups...
  44. Cao S, Zhang P, Zou T, Fei S, Han D, Jin J, et al. Replacement of fishmeal by spirulina Arthrospira platensis affects growth, immune related-gene expression in gibel carp (Carassius auratus gibelio var. CAS III), and its challenge against Aeromonas hydrophila infection. Fish Shellfish Immunol. 2018;79:265-273 pubmed publisher
    ..38?g (SP3.38), 6.76?g (SP6.76) and 13.52?g (SP13.52) per 100?g diet to replace 0%, 25%, 50% and 100% of fishmeal protein, respectively...
  45. Yang J, Yu S, Lao L, Yang M, Chen J, Luo X, et al. Use of moxibustion to treat primary dysmenorrhea at two interventional times: study protocol for a randomized controlled trial. Trials. 2015;16:35 pubmed publisher
    ..The participants assigned to the treatment groups will receive suspended moxibustion treatment at Sanyinjiao (SP6) and Guanyuan (CV4), while the waiting list group will not receive moxibustion treatment until the completion of ..
  46. Bastani F, Sobhani M, Emamzadeh Ghasemi H. Effect of acupressure on fatigue in women with multiple sclerosis. Glob J Health Sci. 2015;7:375-81 pubmed publisher
    ..The experimental group were received acupressure, at the true points (ST36, SP6, LI4) and the placebo group, were received touching at the same points...
  47. Alam M, Rana Z, Islam S. Comparison of the Proximate Composition, Total Carotenoids and Total Polyphenol Content of Nine Orange-Fleshed Sweet Potato Varieties Grown in Bangladesh. Foods. 2016;5: pubmed publisher
    ..Bangladesh Agricultural Research Institute (BARI) Sweet Potato 7 (SP7) contained the highest, whereas BARI SP6 contained the lowest amount of total polyphenol content...
  48. Zhu J, Chen Z, Zhu L, Meng Z, Wu G, Tian Z. Arginine Vasopressin and Arginine Vasopressin Receptor 1b Involved in Electroacupuncture-Attenuated Hypothalamic-Pituitary-Adrenal Axis Hyperactivity in Hepatectomy Rats. Neuromodulation. 2016;19:498-506 pubmed publisher
    ..EA was given during the perioperative period at the Zusanli (ST36) and Sanyinjiao (SP6) points after hepatectomy...
  49. Hao J, Zhu C, Yan B, Yan C, Ling R. Stimulation of KLF14/PLK1 pathway by thrombin signaling potentiates endothelial dysfunction in Type 2 diabetes mellitus. Biomed Pharmacother. 2018;99:859-866 pubmed publisher
    ..using isolated endothelial cells (ECs) identified accumulated Kru¨ppel-like family of transcription factor 14 (KLF14) deposits in ECs from multiple organs as distinct features of T2DM mice...
  50. Liu C, Liu Q, Zhang D, Liu W, Yan X, Zhang X, et al. Insight into the biological effects of acupuncture points by X-ray absorption fine structure. Anal Bioanal Chem. 2018;410:4959-4965 pubmed publisher
    ..Here we show that in the SP6 acupuncture point (Sanyinjiao) the Fe ions are in a high-spin state of approximately t2g4...
  51. Talamillo A, Delgado I, Nakamura T, de Vega S, Yoshitomi Y, Unda F, et al. Role of Epiprofin, a zinc-finger transcription factor, in limb development. Dev Biol. 2010;337:363-74 pubmed publisher
    ..In the present work, we have investigated the role of Epiprofin (Epfn/Sp6), a member of the SP/KLF transcription factor family that is expressed in the limb ectoderm and the ..
  52. Rönn T, Volkov P, Gillberg L, Kokosar M, Perfilyev A, Jacobsen A, et al. Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood. Hum Mol Genet. 2015;24:3792-813 pubmed publisher
    ..Interestingly, many reported epigenetic biomarkers of aging in blood, including ELOVL2, FHL2, KLF14 and GLRA1, also showed significant correlations between adipose tissue DNA methylation and age in our study...
  53. Pei J, Grishin N. C2H2 zinc finger proteins of the SP/KLF, Wilms tumor, EGR, Huckebein, and Klumpfuss families in metazoans and beyond. Gene. 2015;573:91-9 pubmed publisher
    ..Placental mammals have added KLF14 (group E) and KLF18 (group A), and lost KLF5l (KLF5-like) and KLF15l (KLF15-like)...
  54. Calipel A, Lux A, Guérin S, Lefaix J, Laurent C, Bernaudin M, et al. Differential Radiosensitivity of Uveal Melanoma Cell Lines After X-rays or Carbon Ions Radiation. Invest Ophthalmol Vis Sci. 2015;56:3085-94 pubmed publisher
    ..We characterized the radiosensitivity toward x-rays and C-ions of UM cell lines: 92.1, MEL270, SP6.5, MKT-BR, μ2, and TP17...
  55. Zhu F, Lu M, Huang Q, Huang Y, Yang S, Cui Y, et al. Interactive mechanism between avian infectious bronchitis S1 protein T cell peptide and avian MHC I molecule. Virus Res. 2016;215:76-83 pubmed publisher
    ..perform molecular docking of the predicted infectious bronchitis virus (IBV) S1 protein potential epitope peptide Sp6 (NQFYIKLT) and the avian MHC-β2M complex, and demonstrate the interactive mechanism between Sp6 and MHC using ..
  56. Wong R, Major P, Sagar S. Phase 2 Study of Acupuncture-Like Transcutaneous Nerve Stimulation for Chemotherapy-Induced Peripheral Neuropathy. Integr Cancer Ther. 2016;15:153-64 pubmed publisher
    ..Acupuncture treatments were administered to CV6, SP6, ST6, LI11, Bafeng, Baxie and selective Jing points bilaterally...
  57. Wei X, Yang R, Wang C, Jian X, Li L, Liu H, et al. A novel role for the Krüppel-like factor 14 on macrophage inflammatory response and atherosclerosis development. Cardiovasc Pathol. 2017;27:1-8 pubmed publisher
    Genome-wide association studies have shown that Krüppel-like factor 14 (KLF14) is associated with both Type 2 diabetes mellitus and lipid metabolism...
  58. Shen Y, Hsu T, Ling L, You W, Liu C. Identification of low-molecular-weight vitellogenin 1 (Vg1)-like proteins as nucleotide excision repair (NER) factors in developing zebrafish (Danio rerio) using a transcription-based DNA repair assay. Fish Physiol Biochem. 2017;43:663-676 pubmed publisher
    ..a significant up-regulation of UVC or cisplatin-suppressed transcriptional activity of a marker cDNA driven by a SP6 RNA polymerase-regulated promotor after incubating the damaged plasmid with the extracts of 12 hpf embryos or 96 ..
  59. Adly A, Adly A, Adly M, Serry Z. Laser acupuncture versus reflexology therapy in elderly with rheumatoid arthritis. Lasers Med Sci. 2017;32:1097-1103 pubmed publisher
    ..The acupuncture points that were exposed to laser radiation are LR3, ST25, ST36, SI3, SI4, LI4, LI11, SP6, SP9, GB25, GB34, and HT7. While group B received reflexology therapy, both offered 12 sessions over 4 weeks...
  60. Yang M, Ren Y, Lin Z, Tang C, Jia Y, Lai Y, et al. Krüppel-like factor 14 increases insulin sensitivity through activation of PI3K/Akt signal pathway. Cell Signal. 2015;27:2201-8 pubmed publisher
    Genome-wide association studies (GWAS) have shown that Krüppel-like factor 14 (KLF14) is associated with type 2 diabetes mellitus (T2DM). However, no report has demonstrated a relationship between KLF14 and glucose metabolism...
  61. Tu J, Park T, Morado D, Hughes K, Molineux I, Liu J. Dual host specificity of phage SP6 is facilitated by tailspike rotation. Virology. 2017;507:206-215 pubmed publisher
    Bacteriophage SP6 exhibits dual-host adsorption specificity. The SP6 tailspikes are recognized as important in host range determination but the mechanisms underlying dual host specificity are unknown...
  62. Cho S, Jung S, Hong S, Lee E, Lee J, Lee S, et al. Independent validation of DNA-based approaches for age prediction in blood. Forensic Sci Int Genet. 2017;29:250-256 pubmed publisher
    ..T-cell receptor excision circles (sjTRECs) and DNA methylation markers located in the ELOVL2, C1orf132, TRIM59, KLF14, and FHL2 genes were reanalyzed in 100 Korean blood samples to test their associations with chronological age, ..
  63. Xie W, Li L, Zheng X, Yin W, Tang C. The role of Krüppel-like factor 14 in the pathogenesis of atherosclerosis. Atherosclerosis. 2017;263:352-360 pubmed publisher
    ..Recent studies have demonstrated that KLF14, a member of the KLF family, participates in the initiation and progression of atherosclerotic cardiovascular ..
  64. Yu W, Wen G, Lin H, Yang Y, Huang X, Zhou C, et al. Effects of dietary Spirulina platensis on growth performance, hematological and serum biochemical parameters, hepatic antioxidant status, immune responses and disease resistance of Coral trout Plectropomus leopardus (Lacepede, 1802). Fish Shellfish Immunol. 2018;74:649-655 pubmed publisher
    ..platensis: 0% (C), 2% (SP2), 4% (SP4), 6% (SP6), 8% (SP8) and 10% (SP10) as treatment groups, followed by a Vibrio harveyi infection test for 14?d...
  65. Yeruva L, Bowlin A, Spencer N, Maurelli A, Rank R. Chlamydial variants differ in ability to ascend the genital tract in the guinea pig model of chlamydial genital infection. Infect Immun. 2015;83:3176-83 pubmed publisher
    ..Although the variants individually had similar infection kinetics in the cervix, SP6, the virulent variant, could be isolated from the oviducts more often and in greater numbers than the attenuated ..
  66. Torkzahrani S, Mahmoudikohani F, Saatchi K, Sefidkar R, Banaei M. The effect of acupressure on the initiation of labor: A randomized controlled trial. Women Birth. 2017;30:46-50 pubmed publisher
    ..They were categorized into 3 groups; acupressure, sham acupressure and control. Acupressure points SP6, BL 60 and BL 32 were pressured bilaterally...
  67. Silva M, Silva J, Prado W. 100-Hz Electroacupuncture but not 2-Hz Electroacupuncture is Preemptive Against Postincision Pain in Rats. J Acupunct Meridian Stud. 2016;9:200-6 pubmed publisher
    ..on antinociception induced by a 20-minute period of 2-Hz or 100-Hz EA applied to the Zusanli (ST36) and Sanyinjiao (SP6) acupoints before surgical incision, or 10 minutes after or 100 minutes after surgical incision of the hind paw...
  68. Nie Y, Cong P, Liu X, Wang M, Chen Y, He Z. Development of a bacterial-based negative selection system for rapid screening of active single guide RNAs. Biotechnol Lett. 2017;39:351-358 pubmed publisher
    ..We constructed a Cas9/sgRNA plasmid with two SP6 promoters to simultaneously express Cas9 nuclease and the sgRNA and a negative selection plasmid harbouring a ..
  69. Yang L, Wang Y, Mo Q, Liu Z. A comparative study of electroacupuncture at Zhongliao (BL33) and other acupoints for overactive bladder symptoms. Front Med. 2017;11:129-136 pubmed publisher
    ..at BL33), non-acupoint group (needling at the non-acupoint next to BL33), Weizhong (BL40) group, Sanyinjiao (SP6) group, Tongtian (BL7) group, and Hegu (LI4) group...
  70. Du K, Wang X, Chi L, Li W. Role of Sigma-1 Receptor/p38 MAPK Inhibition in Acupoint Catgut Embedding-Mediated Analgesic Effects in Complete Freund's Adjuvant-Induced Inflammatory Pain. Anesth Analg. 2017;125:662-669 pubmed publisher
    ..ACE was applied to bilateral "Kunlun" (BL60), "Zusanli" (ST36), and "Sanyinjiao" (SP6) acupoints in the rat model of inflammatory pain (complete Freund's adjuvant [CFA] intraplantar injection)...
  71. Arinawati D, Miyoshi K, Tanimura A, Horiguchi T, Hagita H, Noma T. Deciphering defective amelogenesis using in vitro culture systems. J Biosci Bioeng. 2018;125:479-489 pubmed publisher
    ..Recently, we found specificity protein 6 (Sp6) mutation in an autosomal-recessive AI rat that was previously named AMI...
  72. DI D, Chen L, Wang L, Wang C, Ju J. [Down-regulation of human intercellular adhesion molecule-1 expression in MCF-7 cells infected by lentiviral short hairpin RNA interference vectors]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015;31:1048-52 pubmed
    ..1-SP6-PGK-GFP vector. After DNA sequencing, three plasmid-based lentiviral packaging system (vector plasmid-psPAX2-pMD2...
  73. Guo Y, Fan Y, Zhang J, Lomberk G, Zhou Z, Sun L, et al. Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production. J Clin Invest. 2015;125:3819-30 pubmed publisher
    ..have revealed that variations near the gene locus encoding the transcription factor Krüppel-like factor 14 (KLF14) are strongly associated with HDL cholesterol (HDL-C) levels, metabolic syndrome, and coronary heart disease...
  74. Nakamura T, Jimenez Rojo L, Koyama E, Pacifici M, de Vega S, Iwamoto M, et al. Epiprofin Regulates Enamel Formation and Tooth Morphogenesis by Controlling Epithelial-Mesenchymal Interactions During Tooth Development. J Bone Miner Res. 2017;32:601-610 pubmed publisher
    ..b>Epiprofin (Epfn), a transcription factor belonging to the Sp family, regulates dental epithelial cell proliferation and is ..
  75. Abaraogu U, Igwe S, Tabansi Ochiogu C. Effectiveness of SP6 (Sanyinjiao) acupressure for relief of primary dysmenorrhea symptoms: A systematic review with meta- and sensitivity analyses. Complement Ther Clin Pract. 2016;25:92-105 pubmed publisher
    We reviewed the available evidence for SP6 (Sanyinjiao) acupressure for the relief of primary dysmenorrhea (PD) symptoms, as well as patients' experiences of this intervention...
  76. Wang X, Jiang Z, Zhang Y, Wang X, Liu L, Fan Z. RNA sequencing analysis reveals protective role of kruppel-like factor 3 in colorectal cancer. Oncotarget. 2017;8:21984-21993 pubmed publisher
    ..In the TCGA cohort, KLF3 (hazard ratio [HR], 0.501; 95% confidence interval [CI], 0.272-0.920; P=0.025), KLF14 (HR, 1.454; 95% CI, 1.059-1.995; P=0.020), and KLF17 (HR, 1.241; 95% CI, 1.030-1.494, P=0...
  77. Venkatesh L, Fasina O, Pintel D. RNAse mapping and quantitation of RNA isoforms. Methods Mol Biol. 2012;883:121-9 pubmed publisher
    ..to a high-specific activity antisense radioactive RNA probe synthesized by in vitro transcription from the SP6 or T7 promoter of an appropriate linearized plasmid template by the bacteriophage SP6 or T7 polymerase, ..
  78. Michael D, Yaniv W, Tal F, Kessler Evan G, Eyal A, Nimrod S, et al. Expandable proximal femoral nail versus gamma proximal femoral nail for the treatment of AO/OTA 31A1-3 fractures. Injury. 2016;47:419-23 pubmed publisher
    The gamma-proximal femoral nail (GPFN) and the expandable proximal femoral nail (EPFN) are two commonly used intramedullary devices for the treatment of AO 31A1-3 proximal femur fractures...
  79. Hirsch H, Yakhontova K, Lu M, Manzetti J. BK Polyomavirus Replication in Renal Tubular Epithelial Cells Is Inhibited by Sirolimus, but Activated by Tacrolimus Through a Pathway Involving FKBP-12. Am J Transplant. 2016;16:821-32 pubmed publisher
    ..Sirolimus impaired BKPyV replication with a 90% inhibitory concentration of 4 ng/mL by interfering with mTOR-SP6-kinase activation...
  80. Nair A, Piaggi P, McLean N, Kaur M, Kobes S, Knowler W, et al. Assessment of established HDL-C loci for association with HDL-C levels and type 2 diabetes in Pima Indians. Diabetologia. 2016;59:481-91 pubmed publisher
    ..Three SNPs, at CETP, KLF14 and HNF4A, associated with type 2 diabetes only in female participants with the HDL-C-lowering allele increasing ..
  81. Shergis J, Ni X, Jackson M, Zhang A, Guo X, Li Y, et al. A systematic review of acupuncture for sleep quality in people with insomnia. Complement Ther Med. 2016;26:11-20 pubmed publisher
    ..Acupuncture point combinations included the use of at least one of the recommended points for insomnia, HT7, GV20, SP6. Pharmacotherapy control was used in 27 studies and sham/placebo in three studies...
  82. Kim Y, Lee H, Cho S. Antidepressant Effects of Pharmacopuncture on Behavior and Brain-Derived Neurotrophic Factor (BDNF) Expression in Chronic Stress Model of Mice. J Acupunct Meridian Stud. 2017;10:402-408 pubmed publisher
    ..They were also injected with distilled water (DW) (CIS + DW) or HJ11 at the acupoints HT7, SP6, and GV20 (CIS + HJ11) an hour before stress...
  83. Jiang Q, Wang M, Li L, Mo H, Song J, Tang Q, et al. Electroacupuncture relieves labour pain and influences the spinal dynorphin/κ-opioid receptor system in rats. Acupunct Med. 2016;34:223-8 pubmed publisher
    ..group, n=20) or received either meperidine (an opioid that is commonly used to treat labour pain, n=20) or EA at SP6, LI4, SP6+LI4 or SP10 (four groups, n=20 each). Labour pain was evaluated by the warm water tail-flick test...
  84. Mookprom S, Boonkum W, Kunhareang S, Siripanya S, Duangjinda M. Genetic evaluation of egg production curve in Thai native chickens by random regression and spline models. Poult Sci. 2017;96:274-281 pubmed publisher
    ..with second, third, and fourth orders (LG2, LG3, LG4), and spline functions with 4, 5, 6, and 8 knots (SP4, SP5, SP6, and SP8)...
  85. Gebhart D, Williams S, Scholl D. Bacteriophage SP6 encodes a second tailspike protein that recognizes Salmonella enterica serogroups C2 and C3. Virology. 2017;507:263-266 pubmed publisher
    b>SP6 is a salmonella phage closely related to coliphage K1-5. K1-5 is notable in that it encodes two polysaccharide-degrading tailspike proteins, an endosialidase that allows it to infect E...
  86. Iwaya C, Kitajima H, Yamamoto K, Maeda Y, Sonoda N, Shibata H, et al. DNA methylation of the Klf14 gene region in whole blood cells provides prediction for the chronic inflammation in the adipose tissue. Biochem Biophys Res Commun. 2018;497:908-915 pubmed publisher
    Krüppel-Like Factor 14 (KLF14) gene, which appears to be a master regulator of gene expression in the adipose tissue and have previously been associated with BMI and Type 2 diabetes (T2D) by large genome-wide association studies...
  87. Setton E, Sharma P. Cooption of an appendage-patterning gene cassette in the head segmentation of arachnids. Proc Natl Acad Sci U S A. 2018;115:E3491-E3500 pubmed publisher
    ..In the fruit fly, Drosophila melanogaster, the Sp6-9 homolog is activated by Wnt-1/wingless (wg) and establishes ventral appendage (leg) fate...
  88. Fan G, Sun L, Shan P, Zhang X, Huan J, Li D, et al. Loss of KLF14 triggers centrosome amplification and tumorigenesis. Nat Commun. 2015;6:8450 pubmed publisher
    ..Here we report that disruption of the Kruppel-like factor 14 (KLF14) gene in mice causes centrosome amplification, aneuploidy and spontaneous tumorigenesis...
  89. Kananen L, Marttila S, Nevalainen T, Jylhävä J, Mononen N, Kähönen M, et al. Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study. BMC Genomics. 2016;17:103 pubmed publisher
    ..Repeatedly reported a-CpGs located in genes ELOVL2, FHL2, PENK and KLF14 were also identified...
  90. Shao J, Liu Z, Wang L, Song Z, Chang H, Han N, et al. Screening of the optimized prescription from Suqingwan in terms of its therapeutic effect on DSS-induced ulcerative colitis by its regulation of inflammatory and oxidative mediators. J Ethnopharmacol. 2017;202:54-62 pubmed publisher
    ..Among the 9 SPs, separate prescription 6, 7 and 8 (SP6, SP7 and SP8) and the SQW formulation all significantly reduced the DAI of the UC mice and, in particular, SP8 had ..
  91. Hong S, Jung S, Lee E, Shin K, Yang W, Lee H. DNA methylation-based age prediction from saliva: High age predictability by combination of 7 CpG markers. Forensic Sci Int Genet. 2017;29:118-125 pubmed publisher
    ..marker candidates (cg00481951, cg19671120, cg14361627, cg08928145, cg12757011, and cg07547549 of the SST, CNGA3, KLF14, TSSK6, TBR1, and SLC12A5 genes, respectively) in addition to a cell type-specific CpG marker (cg18384097 of the ..
  92. Duarte F, Duzzioni M, Leme L, Smith S, De Lima T. Evidence for involvement of NK₃ receptors in the anxiogenic-like effect of SP6-11(C-terminal), a metabolite of substance P, in rats evaluated in the elevated plus-maze. Behav Brain Res. 2016;303:168-75 pubmed publisher
    ..We have previously shown that the anxiogenic-like effects elicited by SP6-11(C-terminal), a specific metabolite of SP, are mediated via NK1 and NK2 receptors...