Gene Symbol: SP110
Description: SP110 nuclear body protein
Alias: IFI41, IFI75, IPR1, VODI, sp110 nuclear body protein, interferon-induced protein 41, 30kD, interferon-induced protein 41/75, interferon-induced protein 75, 52kD, phosphoprotein 41, phosphoprotein 75, speckled 110 kDa, transcriptional coactivator Sp110
Species: human
Products:     SP110

Top Publications

  1. Cai L, Wang Y, Wang J, Chou K. Identification of proteins interacting with human SP110 during the process of viral infections. Med Chem. 2011;7:121-6 pubmed
    Human SP110 plays an important role in resisting intracellular pathogens, and hence has become an important drug target for preventing intracellular pathogen diseases, such as tuberculosis, hepatic veno-occlusive disease, and ..
  2. Watashi K, Hijikata M, Tagawa A, Doi T, Marusawa H, Shimotohno K. Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus. Mol Cell Biol. 2003;23:7498-509 pubmed
    ..These findings likely describe a novel system in which a cytoplasmic viral protein regulates host cell transcription. ..
  3. Roscioli T, Cliffe S, Bloch D, Bell C, Mullan G, Taylor P, et al. Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease. Nat Genet. 2006;38:620-2 pubmed
    We describe mutations in the PML nuclear body protein Sp110 in the syndrome veno-occlusive disease with immunodeficiency, an autosomal recessive disorder of severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent ..
  4. Tosh K, Campbell S, Fielding K, Sillah J, Bah B, Gustafson P, et al. Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa. Proc Natl Acad Sci U S A. 2006;103:10364-10368 pubmed publisher
    ..We have therefore examined the closest human homologue of Ipr1, SP110, for its ability to control susceptibility to M. tuberculosis infection in humans...
  5. Babb C, Keet E, van Helden P, Hoal E. SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population. Hum Genet. 2007;121:521-2 pubmed
    ..Polymorphisms in the human homologue, SP110, have been investigated in various populations with only one study finding an association with TB susceptibility...
  6. Bloch D, Nakajima A, Gulick T, Chiche J, Orth D, de la Monte S, et al. Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. Mol Cell Biol. 2000;20:6138-46 pubmed
    ..In this study, we identified a cDNA encoding a leukocyte-specific nuclear body component designated Sp110. The N-terminal portion of Sp110 was homologous to two previously characterized components of the nuclear body (..
  7. Thye T, Browne E, Chinbuah M, Gyapong J, Osei I, Owusu Dabo E, et al. No associations of human pulmonary tuberculosis with Sp110 variants. J Med Genet. 2006;43:e32 pubmed
    ..in mediating innate immunity in a mouse model of Mycobacterium tuberculosis infection, the human Ipr1 homologue, Sp110, was considered a promising candidate for an association study in human tuberculosis...
  8. Abhimanyu -, Jha P, Jain A, Arora K, Bose M. Genetic association study suggests a role for SP110 variants in lymph node tuberculosis but not pulmonary tuberculosis in north Indians. Hum Immunol. 2011;72:576-80 pubmed publisher
    ..b>SP110, a component of the nuclear body, has been subjected to association studies with conflicting results...
  9. Szeszko J, Healy B, Stevens H, Balabanova Y, Drobniewski F, Todd J, et al. Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis. Hum Genet. 2007;121:155-60 pubmed
    ..We examined whether common sequence variants of its human orthologue, the SP110 gene, are associated with susceptibility to tuberculosis in a human population...

More Information


  1. Liang L, Zhao Y, Yue J, Liu J, Han M, Wang H, et al. Association of SP110 gene polymorphisms with susceptibility to tuberculosis in a Chinese population. Infect Genet Evol. 2011;11:934-9 pubmed publisher
    ..in mediating innate immunity in a mouse model of Mycobacterium tuberculosis infection, the human Ipr1 homologue, SP110 is a recognised candidate gene for control M. tuberculosis infection...
  2. Lei X, Zhu H, Zha L, Wang Y. SP110 gene polymorphisms and tuberculosis susceptibility: a systematic review and meta-analysis based on 10 624 subjects. Infect Genet Evol. 2012;12:1473-80 pubmed publisher
    ..The SP110 (Speckled 110) gene, which is considered as a host genetic susceptibility to TB, has been widely studied in recent ..
  3. Di Bernardo M, Crowther Swanepoel D, Broderick P, Webb E, Sellick G, Wild R, et al. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Nat Genet. 2008;40:1204-10 pubmed publisher
    ..32 (rs11083846, PRKD2; P = 3.96 x 10(-9)). These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL...
  4. Png E, Alisjahbana B, Sahiratmadja E, Marzuki S, Nelwan R, Adnan I, et al. Polymorphisms in SP110 are not associated with pulmonary tuberculosis in Indonesians. Infect Genet Evol. 2012;12:1319-23 pubmed publisher
    ..2005), has prompted studies on its human homolog; SP110 in humans...
  5. Nicewonger J, Suck G, Bloch D, Swaminathan S. Epstein-Barr virus (EBV) SM protein induces and recruits cellular Sp110b to stabilize mRNAs and enhance EBV lytic gene expression. J Virol. 2004;78:9412-22 pubmed
  6. Cai L, Deng S, Liang L, Pan H, Zhou J, Wang M, et al. Identification of genetic associations of SP110/MYBBP1A/RELA with pulmonary tuberculosis in the Chinese Han population. Hum Genet. 2013;132:265-73 pubmed publisher
    Genetic factors play important roles in the development of tuberculosis (TB). SP110 is a promising candidate target for controlling TB infections...
  7. Kodama Y, Tamura T, Hirasawa W, Nakamura K, Sano H. A novel protein phosphorylation pathway involved in osmotic-stress response in tobacco plants. Biochimie. 2009;91:533-9 pubmed
    ..The structure of NtCK25 was found to be similar to a human nuclear body protein, SP110, which is involved in DNA/protein binding regulation...
  8. Coon H, Darlington T, Diblasi E, Callor W, Ferris E, Fraser A, et al. Genome-wide significant regions in 43 Utah high-risk families implicate multiple genes involved in risk for completed suicide. Mol Psychiatry. 2018;: pubmed publisher
    ..However, additional association tests yielded four significant PsychArray variants (SP110, rs181058279; AGBL2, rs76215382; SUCLA2, rs121908538; APH1B, rs745918508), raising the likelihood that these genes ..
  9. Zucchelli C, Tamburri S, Filosa G, Ghitti M, Quilici G, Bachi A, et al. Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain. Biochim Biophys Acta Gen Subj. 2018;1863:456-465 pubmed publisher
    Human Sp140 protein is a leukocyte-specific member of the speckled protein (Sp) family (Sp100, Sp110, Sp140, Sp140L), a class of multi-domain nuclear proteins involved in intrinsic immunity and transcriptional regulation...
  10. Wu H, Wang Y, Zhang Y, Yang M, Lv J, Liu J, et al. TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis. Proc Natl Acad Sci U S A. 2015;112:E1530-9 pubmed publisher
    ..we report site-specific knockin of the transcription activator-like effector (TALE) nickase-mediated SP110 nuclear body protein gene (SP110) via homologous recombination to produce tuberculosis-resistant cattle...
  11. Leu J, Chang S, Mu C, Chen M, Yan B. Functional domains of SP110 that modulate its transcriptional regulatory function and cellular translocation. J Biomed Sci. 2018;25:34 pubmed publisher
    b>SP110, an interferon-induced nuclear protein, belongs to the SP100/SP140 protein family...
  12. Saare M, Hämarik U, Venta R, Panarina M, Zucchelli C, Pihlap M, et al. SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis. J Immunol Res. 2015;2015:526518 pubmed publisher
    ..1. The widely expressed SP100 and the leukocyte-specific proteins SP110 and SP140 have been associated with transcriptional regulation and various human diseases...
  13. Thanmalagan R, Naorem L, Venkatesan A. Expression Data Analysis for the Identification of Potential Biomarker of Pregnancy Associated Breast Cancer. Pathol Oncol Res. 2017;23:537-544 pubmed publisher
    ..These studies emphasis that the genes KLF12, FEN1 MUC1 and SP110, can be chosen as target, which control cancer development, without any harm to pregnancy as well as fetal ..
  14. Wu Y, Guo Z, Yao K, Miao Y, Liang S, Liu F, et al. The Transcriptional Foundations of Sp110-mediated Macrophage (RAW264.7) Resistance to Mycobacterium tuberculosis H37Ra. Sci Rep. 2016;6:22041 pubmed publisher
    ..3 million deaths each year. The nuclear body protein, Sp110, has been linked to TB resistance and previous work showed that it enhances macrophage apoptosis upon Mtb ..
  15. Wu Y, Liu F, Zhang Y, Wang Y, Guo Z, Zhang Y. Characterization of promoter of the tuberculosis-resistant gene intracellular pathogen resistance 1. Immunol Res. 2016;64:143-54 pubmed publisher
    ..Expression of the intracellular pathogen resistance 1 (Ipr1) gene could enhance the host resistance to mycobacterium...
  16. Li L, Wang Q, Han L, Wang J, Shao S, Wang L, et al. Molecular characterization of Sp110 gene in pigs. Mol Genet Genomics. 2016;291:1431-42 pubmed publisher
    Speckled 110 kDa (Sp110) plays an important role in infectious diseases, as revealed by studies in humans. However, little is known regarding porcine Sp110...
  17. Yao K, Wu Y, Chen Q, Zhang Z, Chen X, Zhang Y. The Arginine/Lysine-Rich Element within the DNA-Binding Domain Is Essential for Nuclear Localization and Function of the Intracellular Pathogen Resistance 1. PLoS ONE. 2016;11:e0162832 pubmed publisher
    The mouse intracellular pathogen resistance 1 (Ipr1) gene plays important roles in mediating host immunity and previous work showed that it enhances macrophage apoptosis upon mycobacterium infection...
  18. Chen Q, Tong Q, Ge H, Li W, Liu J, Wang Y, et al. Identification of SP110 in horse (Equus caballus): Isolation of novel splice variants and evidence of activation effects on macrophages. Tuberculosis (Edinb). 2016;101:85-94 pubmed publisher
    b>SP110 has previously shown to be a genetic determinant of host resistance to the intracellular pathogen infection in mouse and human. However, its relevant biological information in large non-primate animals still remains unknown...
  19. Wang Y, He X, Du Y, Su J, Gao M, Ma Y, et al. Transgenic cattle produced by nuclear transfer of fetal fibroblasts carrying Ipr1 gene at a specific locus. Theriogenology. 2015;84:608-16 pubmed publisher
    This study aimed to assess the effects of the intracellular pathogen resistance 1 (Ipr1) transgene on preventing infection of Mycobacterium bovis in cattle...
  20. Ivansson E, Megquier K, Kozyrev S, Murén E, Körberg I, Swofford R, et al. Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy. Proc Natl Acad Sci U S A. 2016;113:E3091-100 pubmed publisher
    ..The analysis revealed a modifier locus on canine chromosome 25. A haplotype within the SP110 nuclear body protein (SP110) was present in 40% of affected compared with 4% of unaffected dogs (P = 1...
  21. Alujević D, Fatovic Ferencic S. [The Black Eagle pharmacy in Petrinja - first civil pharmacy on the territory of Banska krajina]. Acta Med Hist Adriat. 2017;15:9-30 pubmed
    ..Osobita pozornost posve?ena je ljekarni?koj obitelji Panac koja kroz ?etiri generacije vodi ovu ljekarnu u razdoblju od 1822. do 1950. godine...
  22. Leu J, Chen M, Chang S, Yu S, Lin C, Wang H, et al. SP110b Controls Host Immunity and Susceptibility to Tuberculosis. Am J Respir Crit Care Med. 2017;195:369-382 pubmed publisher
    ..We also performed genetic characterization of patients with TB to investigate the role of SP110 in controlling host susceptibility to TB...
  23. Berndt S, Skibola C, Joseph V, Camp N, Nieters A, Wang Z, et al. Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Nat Genet. 2013;45:868-76 pubmed publisher
    ..3 (ODF1, P=5.40×10(-8)) and 5p15.33 (TERT, P=1.92×10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism. ..
  24. Fox G, Sy D, Nhung N, Yu B, Ellis M, Van Hung N, et al. Polymorphisms of SP110 are associated with both pulmonary and extra-pulmonary tuberculosis among the Vietnamese. PLoS ONE. 2014;9:e99496 pubmed publisher
    ..tuberculosis. SP110 is an interferon-responsive nuclear body protein with critical roles in cell cycling, apoptosis and immunity to ..
  25. Jiang S, Li L, Yue J, Chen W, Yang C, Wan C, et al. The effects of SP110's associated genes on fresh cavitary pulmonary tuberculosis in Han Chinese population. Clin Exp Med. 2016;16:219-25 pubmed publisher
    b>SP110 is a promising anti-Mycobacterium tuberculosis (MTB) gene. To investigate the effects of SP110 and its associated genes, i.e...
  26. Larsen M, Kornblit B, Larsen M, Masmas T, Nielsen M, Thiim M, et al. Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2010;16:1370-81 pubmed publisher
    ..Furthermore, our data suggest a possible role for in silico based miHA predictions in donor selection as well as in selecting candidate miHAs for further evaluation in in vitro and in vivo experiments. ..
  27. Slager S, Goldin L, Strom S, Lanasa M, Spector L, Rassenti L, et al. Genetic susceptibility variants for chronic lymphocytic leukemia. Cancer Epidemiol Biomarkers Prev. 2010;19:1098-102 pubmed publisher
  28. Motsinger Reif A, Antas P, Oki N, Levy S, Holland S, Sterling T. Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis. BMC Med Genet. 2010;11:37 pubmed publisher
    ..Additional studies of the underlying mechanism of these genetic variants are warranted. ..
  29. Sengupta I, Das D, Singh S, Chakravarty R, Das C. Host transcription factor Speckled 110 kDa (Sp110), a nuclear body protein, is hijacked by hepatitis B virus protein X for viral persistence. J Biol Chem. 2017;292:20379-20393 pubmed publisher
    ..Here, we report that the PML-NB protein Speckled 110 kDa (Sp110) is SUMO1-modified and undergoes a deSUMOylation-driven release from the PML-NB in the presence of HBV...
  30. Ruan J, Xu J, Chen Tsai R, Li K. Genome editing in livestock: Are we ready for a revolution in animal breeding industry?. Transgenic Res. 2017;26:715-726 pubmed publisher
    ..resistant to porcine reproductive and respiratory syndrome (PRRS, also referred to as "blue ear disease"), and a SP110 gene knock-in cow less susceptible to tuberculosis...
  31. Marquardsen F, Baldin F, Wunderer F, Al Herz W, Mikhael R, Lefranc G, et al. Detection of Sp110 by Flow Cytometry and Application to Screening Patients for Veno-occlusive Disease with Immunodeficiency. J Clin Immunol. 2017;37:707-714 pubmed publisher
    Mutations in Sp110 are the underlying cause of veno-occlusive disease with immunodeficiency (VODI), a combined immunodeficiency that is difficult to treat and often fatal...
  32. Wu Y, Guo Z, Liu F, Yao K, Gao M, Luo Y, et al. Sp110 enhances macrophage resistance to Mycobacterium tuberculosis via inducing endoplasmic reticulum stress and inhibiting anti-apoptotic factors. Oncotarget. 2017;8:64050-64065 pubmed publisher
    ..3 million deaths annually. Expression of the mouse Sp110 nuclear body protein (Sp110) upregulates the apoptotic pathway, which plays an essential role in enhancing host immunity to <..
  33. Slager S, Skibola C, Di Bernardo M, Conde L, Broderick P, McDonnell S, et al. Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. Blood. 2012;120:843-6 pubmed publisher
    ..This finding provides additional support for polygenic inheritance to CLL and provides further insight into the biologic basis of disease development. ..
  34. Ren G, You J, Gong X, Zhang X, Zhao L, Wei X, et al. SP110 and PMP22 polymorphisms are associated with tuberculosis risk in a Chinese-Tibetan population. Oncotarget. 2016;7:66100-66108 pubmed publisher
    Susceptibility to tuberculosis (TB) is partially dependent on host genetic variability. SP110 and PMP22 are candidate genes identified in this study as associated with human susceptibility to TB...
  35. McLaren P, Gawanbacht A, Pyndiah N, Krapp C, Hotter D, Kluge S, et al. Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses. Retrovirology. 2015;12:41 pubmed publisher
    ..Unexpectedly, over-expression of two factors (IL1A, SP110) significantly increased infectious HIV-1 production...
  36. Kadereit S, Gewert D, Galabru J, Hovanessian A, Meurs E. Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins. J Biol Chem. 1993;268:24432-41 pubmed
    ..However, the presence of nuclear targeting sequences, phosphorylation sites, and helix-loop-helix motif is consistent with a role of these proteins in the mechanism of transduction of the interferon action. ..
  37. Cliffe S, Bloch D, Suryani S, Kamsteeg E, Avery D, Palendira U, et al. Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome. J Allergy Clin Immunol. 2012;130:735-742.e6 pubmed publisher
    Mutations in the SP110 gene result in infantile onset of the autosomal recessive primary immunodeficiency disease veno-occlusive disease with immunodeficiency syndrome (VODI), which is characterized by hypogammaglobulinemia, T-cell ..
  38. Cong J, Li G, Zhou D, Tao Y, Xiong Y. [Study on relation between Sp110 gene polymorphism and tuberculosis genetic susceptibility of Chongqing Han People]. Wei Sheng Yan Jiu. 2010;39:540-4 pubmed
    To investigate the association of Sp110 gene SNP with tuberculosis occurrence of Chongqing Han people. Design Use the case-control study design, and collect risk factors of tuberculosis by questionnaires...
  39. De La Fuente J, Manzano Román R, Blouin E, Naranjo V, Kocan K. Sp110 transcription is induced and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. BMC Infect Dis. 2007;7:110 pubmed
    ..The human Sp110 gene is a member of the nuclear body (NB) components that functions as a nuclear hormone receptor transcriptional ..
  40. Cliffe S, Wong M, Taylor P, Ruga E, Wilcken B, Lindeman R, et al. The first prenatal diagnosis for veno-occlusive disease and immunodeficiency syndrome, an autosomal recessive condition associated with mutations in SP110. Prenat Diagn. 2007;27:674-6 pubmed
    ..Homozygous mutations in the gene SP110 are the genetic basis of VODI...
  41. Welsh G, Kadereit S, Coccia E, Hovanessian A, Meurs E. Colocalization within the nucleolus of two highly related IFN-induced human nuclear phosphoproteins with nucleolin. Exp Cell Res. 1999;250:62-74 pubmed
    ..In view of this and since 41 and 75 have homology to proteins involved in regulating gene expression, we suggest that, in association with nucleolin, they play a role in ribosome biogenesis. ..
  42. Warren E, Vigneron N, Gavin M, Coulie P, Stroobant V, Dalet A, et al. An antigen produced by splicing of noncontiguous peptides in the reverse order. Science. 2006;313:1444-7 pubmed
    ..Here we describe a human minor histocompatibility antigen created by a polymorphism in the SP110 nuclear phosphoprotein gene...