Sp1

Summary

Gene Symbol: Sp1
Description: Sp1 transcription factor
Alias: transcription factor Sp1, specificity protein 1
Species: human
Products:     Sp1

Top Publications

  1. Davis W, Chen Z, Ile K, Tew K. Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors. Nucleic Acids Res. 2003;31:1097-107 pubmed
    ..two GC-boxes located in the proximal promoter of the ABCA2 gene that contain overlapping sites for the EGR-1 and Sp1 transcription factors...
  2. He S, Sun J, Li L, Davie J. Differential intranuclear organization of transcription factors Sp1 and Sp3. Mol Biol Cell. 2005;16:4073-83 pubmed
    b>Sp1 and Sp3 are ubiquitously expressed mammalian transcription factors that activate or repress the expression of a variety of genes and are thought to compete for the same DNA binding site...
  3. Bin L, Howell M, Kim B, Streib J, Hall C, Leung D. Specificity protein 1 is pivotal in the skin's antiviral response. J Allergy Clin Immunol. 2011;127:430-438.e1-2 pubmed publisher
    Previous studies have found specificity protein (Sp) 1 transcription factor in the viral replication machinery and postulated that Sp1 was required for viral replication in host cells.
  4. Mottet D, Pirotte S, Lamour V, Hagedorn M, Javerzat S, Bikfalvi A, et al. HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism. Oncogene. 2009;28:243-56 pubmed publisher
    ..Using small interfering RNAs, we found that HDAC4 participates in the repression of p21(WAF1/Cip1) through Sp1/Sp3-, but not p53-binding sites...
  5. Chuang J, Wu C, Lai M, Chang W, Hung J. Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells. Int J Cancer. 2009;125:2066-76 pubmed publisher
    Numerous studies have documented that Sp1 expression level were elevated in various human cancers...
  6. Amodio N, Di Martino M, Foresta U, Leone E, Lionetti M, Leotta M, et al. miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1. Cell Death Dis. 2012;3:e436 pubmed publisher
    ..We identified Sp1, a transcription factor endowed with oncogenic activity, as a negative regulator of miR-29b expression in MM cells...
  7. Lin R, Wu C, Chang J, Juan L, Hsu H, Chen C, et al. Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer. Cancer Res. 2010;70:5807-17 pubmed publisher
    ..Here, we showed that wild-type p53 negatively regulated DNMT1 expression by forming a complex with specificity protein 1 (Sp1) protein and chromatin modifiers on the DNMT1 promoter...
  8. Nam E, Lee Y, Park Y, Lee J, Kim S. ZEB2 upregulates integrin ?5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells. Carcinogenesis. 2012;33:563-71 pubmed publisher
    ..ZEB2 was found to activate the integrin ?5 and vimentin promoters by interacting with and activating the transcription factor Sp1, suggesting that cooperation between ZEB2 and Sp1 represents a novel mechanism of mesenchymal gene ..
  9. Chuang Y, Huang W, Park S, Persaud S, Hung C, Ho P, et al. Promyelocytic leukemia protein in retinoic acid-induced chromatin remodeling of Oct4 gene promoter. Stem Cells. 2011;29:660-9 pubmed publisher
    ..proliferating stem cells, Pml-nuclear body, along with transcription factors TR2, steroidogenic factor 1 (SF1) and Sp1, and Brg1-dependent chromatin remodeling complex (BRGC), associates with conserved region 1 (CR1) of this promoter ..

More Information

Publications77

  1. Wang Y, Yang W, Chang W, Hung J. Interplay of posttranslational modifications in Sp1 mediates Sp1 stability during cell cycle progression. J Mol Biol. 2011;414:1-14 pubmed publisher
    Although Sp1 is known to undergo posttranslational modifications such as phosphorylation, glycosylation, acetylation, sumoylation, and ubiquitination, little is known about the possible interplay between the different forms of Sp1 that ..
  2. Guan H, Cai J, Zhang N, Wu J, Yuan J, Li J, et al. Sp1 is upregulated in human glioma, promotes MMP-2-mediated cell invasion and predicts poor clinical outcome. Int J Cancer. 2012;130:593-601 pubmed publisher
    b>Sp1, the first identified transcription factor, has been reported to be associated with the development and progression of various human cancer types...
  3. Yuan J, Yang F, Chen B, Lu Z, Huo X, Zhou W, et al. The histone deacetylase 4/SP1/microrna-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma. Hepatology. 2011;54:2025-35 pubmed publisher
    ..miR-200a and its promoter activity and reduced the histone H3 acetylation level at the mir-200a promoter through a Sp1-dependent pathway...
  4. Kong L, Liao C, Fei F, Guo X, Xing J, Chen Z. Transcription factor Sp1 regulates expression of cancer-associated molecule CD147 in human lung cancer. Cancer Sci. 2010;101:1463-70 pubmed publisher
    ..the human CD147 gene and identified a critical promoter region at -108 to -42 which contained one binding site for Sp1, which was essential in up-regulating CD147 promoter activity...
  5. Burnett J, Miller Jensen K, Shah P, Arkin A, Schaffer D. Control of stochastic gene expression by host factors at the HIV promoter. PLoS Pathog. 2009;5:e1000260 pubmed publisher
    ..The HIV-1 promoter contains cis-acting Sp1 and NF-kappaB elements that regulate gene expression via the recruitment of both activating and repressing ..
  6. Li F, Jiang Z, Wang K, Guo J, Hu G, Sun L, et al. Transactivation of the human NME5 gene by Sp1 in pancreatic cancer cells. Gene. 2012;503:200-7 pubmed publisher
    ..In silico analysis predicted that transcription factor Sp1 binds to both GC-boxes, which were confirmed by EMSA and ChIP...
  7. Jin W, Chen Y, Di G, Miron P, Hou Y, Gao H, et al. Estrogen receptor (ER) beta or p53 attenuates ERalpha-mediated transcriptional activation on the BRCA2 promoter. J Biol Chem. 2008;283:29671-80 pubmed publisher
    ..protein/p300, p68/p72, and MyoD and formed an activating transcriptional complex that could bind to many Sp1 sites on the BRCA2 promoter and activate its transcription by inducing histone acetylations...
  8. Woo S, Kwon M, Geng Z, Chen Z, Ivanov A, Bhatta S, et al. Sequential activation of hypoxia-inducible factor 1 and specificity protein 1 is required for hypoxia-induced transcriptional stimulation of Abcc8. J Cereb Blood Flow Metab. 2012;32:525-36 pubmed publisher
    ..a series of luciferase reporter assays studying the Abcc8 promoter revealed that binding sites for specificity protein 1 (Sp1), but not for HIF, were required for stimulation of Abcc8 transcription by HIF1?...
  9. Higashimura Y, Nakajima Y, Yamaji R, Harada N, Shibasaki F, Nakano Y, et al. Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells. Arch Biochem Biophys. 2011;509:1-8 pubmed publisher
    ..ChIP analysis showed that Sp1 bound to the GC-box in MCF-7 cells, but not in LNCaP cells, in normoxia and hypoxia...
  10. Liu S, Wu L, Pang J, Santhanam R, Schwind S, Wu Y, et al. Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia. Cancer Cell. 2010;17:333-47 pubmed publisher
    ..we show that KIT mutations lead to MYC-dependent miR-29b repression and increased levels of the miR-29b target Sp1 in KIT-driven leukemia...
  11. Kou X, Hao T, Meng Z, Zhou Y, Gan Y. Acetylated Sp1 inhibits PTEN expression through binding to PTEN core promoter and recruitment of HDAC1 and promotes cancer cell migration and invasion. Carcinogenesis. 2013;34:58-67 pubmed publisher
    b>Specificity protein 1 (Sp1) is often overexpressed in cancer cells. Its binding sites are known to exist in the phosphatase and tension homolog deleted on chromosome 10 (PTEN) promoter...
  12. Convertini P, Infantino V, Bisaccia F, Palmieri F, Iacobazzi V. Role of FOXA and Sp1 in mitochondrial acylcarnitine carrier gene expression in different cell lines. Biochem Biophys Res Commun. 2011;404:376-81 pubmed publisher
    ..Through deletion analysis, an activation domain (-334/-80 bp) was identified which contains FOXA and Sp1 active sites...
  13. Jeon B, Yoo J, Choi W, Lee C, Yoon H, Hur M. Proto-oncogene FBI-1 (Pokemon/ZBTB7A) represses transcription of the tumor suppressor Rb gene via binding competition with Sp1 and recruitment of co-repressors. J Biol Chem. 2008;283:33199-210 pubmed publisher
    ..The Rb promoter also contains two Sp1 binding sites: GC-box 1 (bp -65 to -56) and GC-box 2 (bp -18 to -9), the latter of which is also bound by FBI-1...
  14. Wang J, Liu X, Ni P, Gu Z, Fan Q. SP1 is required for basal activation and chromatin accessibility of CD151 promoter in liver cancer cells. Biochem Biophys Res Commun. 2010;393:291-6 pubmed publisher
    ..The mechanism on how CD151 is expressed remains unclear. Here we have identified SP1 is a protein functioning in constitutive activation of CD151...
  15. Eltzschig H, Kohler D, Eckle T, Kong T, Robson S, Colgan S. Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. Blood. 2009;113:224-32 pubmed publisher
    ..chromatin immunoprecipitation, and inhibition by antisense, revealed a critical role for transcription-factor Sp1 in hypoxia-induction of CD39...
  16. Singh D, Bhargavan B, Chhunchha B, Kubo E, Kumar A, Fatma N. Transcriptional protein Sp1 regulates LEDGF transcription by directly interacting with its cis-elements in GC-rich region of TATA-less gene promoter. PLoS ONE. 2012;7:e37012 pubmed publisher
    ..we report that LEDGF/p75 gene is TATA-less, contains GC-rich cis elements and is transcriptionally regulated by Sp1 involving small ubiquitin-like modifier (Sumo1)...
  17. Xiang Z, Qiao L, Zhou Y, Babiuk L, Liu Q. Hepatitis C virus nonstructural protein-5A activates sterol regulatory element-binding protein-1c through transcription factor Sp1. Biochem Biophys Res Commun. 2010;402:549-53 pubmed publisher
    ..Additional analysis showed that transcriptional factor Sp1 is involved in SREBP-1c activation by HCV-3a NS5A because inhibition of Sp1 activity by mithramycin A or a dominant-..
  18. Ito H, Yoshida K, Murakami M, Hagiwara K, Sasaki N, Kobayashi M, et al. Heterogeneous sphingosine-1-phosphate lyase gene expression and its regulatory mechanism in human lung cancer cell lines. Biochim Biophys Acta. 2011;1811:119-28 pubmed publisher
    ..human SPL revealed that the most important region was located between -136bp and -88bp from the first exon, where 2 Sp1 sites exist but no GATA site...
  19. Dalvai M, Mondesert O, Bourdon J, Ducommun B, Dozier C. Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors. Oncogene. 2011;30:2282-8 pubmed publisher
    ..analyses of the Cdc25B promoter revealed that downregulation by p53 is dependent on the presence of functional Sp1/Sp3 and NF-Y binding sites...
  20. Bocangel D, Sengupta S, Mitra S, Bhakat K. p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor. Anticancer Res. 2009;29:3741-50 pubmed
    ..Here we report that p53 sequesters the Sp1 transcription factor to prevent its binding to the cognate cis elements in the MGMT promoter and thus inhibits MGMT ..
  21. Mbonye U, Karn J. Control of HIV latency by epigenetic and non-epigenetic mechanisms. Curr HIV Res. 2011;9:554-67 pubmed
  22. Sysa P, Potter J, Liu X, Mezey E. Transforming growth factor-beta1 up-regulation of human alpha(1)(I) collagen is mediated by Sp1 and Smad2 transacting factors. DNA Cell Biol. 2009;28:425-34 pubmed publisher
    ..Smads bind in association with Sp1 to the CC(GG)-rich TGFbeta1 responsive element of the promoter that lacks the classical Smad recognition element, ..
  23. Jutooru I, Chadalapaka G, Lei P, Safe S. Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. J Biol Chem. 2010;285:25332-44 pubmed publisher
    ..curcumin decreased expression of p50 and p65 proteins and NFkappaB-dependent transactivation and also decreased Sp1, Sp3, and Sp4 transcription factors that are overexpressed in pancreatic cancer cells...
  24. Liao M, Zhang Y, Kang J, Dufau M. Coactivator function of positive cofactor 4 (PC4) in Sp1-directed luteinizing hormone receptor (LHR) gene transcription. J Biol Chem. 2011;286:7681-91 pubmed publisher
    ..While overexpression of PC4 alone had no effect on the LHR gene, it significantly enhanced Sp1- but not Sp3-mediated LHR transcriptional activity...
  25. Kim H, Ko M, Kim H, Cho W, Lee S, Lee B, et al. Transcription factor Sp1 regulates basal transcription of the human DRG2 gene. Biochim Biophys Acta. 2011;1809:184-90 pubmed publisher
    ..Mutation of a putative stimulating protein 1 (Sp1) regulatory site located at position -108 resulted in a significant decline in DRG2 promoter activity...
  26. Siliciano R, Greene W. HIV latency. Cold Spring Harb Perspect Med. 2011;1:a007096 pubmed publisher
    ..Several approaches are under exploration for reactivating latent virus with the hope that this will allow elimination of the latent reservoir. ..
  27. Hsu T, Wang M, Chen S, Huang S, Yeh Y, Su W, et al. Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth. Mol Pharmacol. 2012;82:1115-28 pubmed publisher
    Previous studies have shown that the inhibitory effect of betulinic acid (BA) on specificity protein 1 (Sp1) expression is involved in the prevention of cancer progression, but the mechanism of this effect remains to be delineated...
  28. Wang X, Yan Z, Fulciniti M, Li Y, Gkotzamanidou M, Amin S, et al. Transcription factor-pathway coexpression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma. Leukemia. 2014;28:894-903 pubmed publisher
    ..In contrast, TrFs ESR1 (estrogen receptor 1), SP1 and E2F1 have significantly lower coexpression with cell cycle arrest in NHMM...
  29. Yan L, Kang M, Qin Z, Zhang W, Li Y, Ou H. An intronic miRNA regulates expression of the human endothelial nitric oxide synthase gene and proliferation of endothelial cells by a mechanism related to the transcription factor SP-1. PLoS ONE. 2013;8:e70658 pubmed publisher
    ..This study was to investigate the molecular mechanisms underlying the 27nt-miRNA-mediated regulation of expression of the endothelial nitric oxide synthase (eNOS) gene...
  30. Xu Z, Xiao S, Xu P, Xie Q, Cao L, Wang D, et al. miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB. J Biol Chem. 2011;286:21401-12 pubmed publisher
    ..Deletion mutant analysis of the miR-365 promoter showed that two transcription factors, Sp1 and NF-?B, are essential for the transcriptional regulation of miR-365...
  31. Lu S, Archer M. Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells. Int J Cancer. 2010;126:416-25 pubmed publisher
    ..How cancer cells coordinate de novo lipogenesis and proliferation has not been investigated. Transcription factors Sp1, Sp3 and Sp4 are overexpressed in a variety of cancers and regulate gene expression by interacting with GC-rich Sp1 ..
  32. Law A, Yeung B, Ching L, Wong C. Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29. J Cell Biochem. 2011;112:2089-96 pubmed publisher
    ..In this study, we reported that the transcriptional factor, specificity protein 1 (Sp1) in association with retinoblastoma (Rb) repressed STC1 gene transcription in TSA-treated HT29 cells...
  33. Beauchef G, Bigot N, Kypriotou M, Renard E, Porée B, Widom R, et al. The p65 subunit of NF-?B inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3). J Biol Chem. 2012;287:3462-78 pubmed publisher
    ..This 51-bp region mediates the action of two zinc fingers, Sp1 (specific protein-1) and Sp3, acting as trans-activators of type I collagen expression in ANF and SF...
  34. Ito T, Kitamura H, Uwatoko C, Azumano M, Itoh K, Kuwahara J. Interaction of Sp1 zinc finger with transport factor in the nuclear localization of transcription factor Sp1. Biochem Biophys Res Commun. 2010;403:161-6 pubmed publisher
    b>Transcription factor Sp1 is localized in the nucleus and regulates the expression of many cellular genes, but the nuclear transport mechanism of Sp1 is not well understood...
  35. Kadam S, McAlpine G, Phelan M, Kingston R, Jones K, Emerson B. Functional selectivity of recombinant mammalian SWI/SNF subunits. Genes Dev. 2000;14:2441-51 pubmed
  36. Jungert K, Buck A, Buchholz M, Wagner M, Adler G, Gress T, et al. Smad-Sp1 complexes mediate TGFbeta-induced early transcription of oncogenic Smad7 in pancreatic cancer cells. Carcinogenesis. 2006;27:2392-401 pubmed
    The transcription factor Sp1 has been implicated in cell-type-specific activation of transforming growth factor-beta (TGFbeta) target genes in normal epithelial cells as well as in aberrant gene activation by TGFbeta in epithelial tumor ..
  37. Karlseder J, Rotheneder H, Wintersberger E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol Cell Biol. 1996;16:1659-67 pubmed
    ..for growth-regulated expression, the murine thymidine kinase gene carries a single binding site for transcription factor Sp1; about 10 bp downstream of this site, there is a binding motif for transcription factor E2F...
  38. Gartel A, Ye X, Goufman E, Shianov P, Hay N, Najmabadi F, et al. Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc Natl Acad Sci U S A. 2001;98:4510-5 pubmed
    ..This region contains multiple Sp1-binding sites and a potential initiator element, but no canonical Myc DNA-binding sites...
  39. Suzuki T, Kimura A, Nagai R, Horikoshi M. Regulation of interaction of the acetyltransferase region of p300 and the DNA-binding domain of Sp1 on and through DNA binding. Genes Cells. 2000;5:29-41 pubmed
    ..interaction between the acetyltransferase region of p300 and the DNA-binding domain (DBD) of the transcription factor Sp1. This interaction stimulates DNA binding by the DBD of Sp1, which is mediated primarily by physical ..
  40. Yedavalli V, Benkirane M, Jeang K. Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1. J Biol Chem. 2003;278:6404-10 pubmed
    ..We further showed that Sp1 is necessary and sufficient for this DNA-targeted activity...
  41. Chadalapaka G, Jutooru I, Chintharlapalli S, Papineni S, Smith R, Li X, et al. Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Res. 2008;68:5345-54 pubmed publisher
    ..The results show that curcumin induced proteasome-dependent down-regulation of Sp1, Sp3, and Sp4 in 253JB-V and KU7 cells...
  42. Wang L, Guan X, Gong W, Yao J, Peng Z, Wei D, et al. Altered expression of transcription factor Sp1 critically impacts the angiogenic phenotype of human gastric cancer. Clin Exp Metastasis. 2005;22:205-13 pubmed
    Our recent study has shown that transcription factor Sp1 is an independent prognostic factor in gastric cancer. However, it is unclear how Sp1 impacts gastric cancer biology...
  43. Zaniolo K, Rufiange A, Leclerc S, Desnoyers S, Guérin S. Regulation of the poly(ADP-ribose) polymerase-1 gene expression by the transcription factors Sp1 and Sp3 is under the influence of cell density in primary cultured cells. Biochem J. 2005;389:423-33 pubmed
    ..directed by the PARP-1 gene promoter is mainly dictated through its recognition by the transcription factors Sp1 and Sp3 (where Sp is specificity protein)...
  44. Bond G, Hu W, Bond E, Robins H, Lutzker S, Arva N, et al. A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell. 2004;119:591-602 pubmed
    ..SNP309) is found in the MDM2 promoter and is shown to increase the affinity of the transcriptional activator Sp1, resulting in higher levels of MDM2 RNA and protein and the subsequent attenuation of the p53 pathway...
  45. Goto T, Matsui Y, Fernandes R, Hanson D, Kubo T, Yukata K, et al. Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. J Bone Miner Res. 2006;21:661-73 pubmed
    ..By studying Saos-2 cells, we showed that the transcription factors, Sp1, Sp3, and Sp7 (Osterix), regulate COL11A2 expression through its proximal promoter...
  46. Jackson S, Tjian R. O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation. Cell. 1988;55:125-33 pubmed
    ..Here we show that the human RNA polymerase II transcription factor Sp1 bears multiple O-linked N-acetylglucosamine (GlcNAc) monosaccharide residues...
  47. Harrich D, Garcia J, Wu F, Mitsuyasu R, Gonazalez J, Gaynor R. Role of SP1-binding domains in in vivo transcriptional regulation of the human immunodeficiency virus type 1 long terminal repeat. J Virol. 1989;63:2585-91 pubmed
    ..These include the negative regulatory, enhancer, SP1, TATA, and TAR regions...
  48. Xia Y, Jiang B, Zou Y, Gao G, Shang L, Chen B, et al. Sp1 and CREB regulate basal transcription of the human SNF2L gene. Biochem Biophys Res Commun. 2008;368:438-44 pubmed publisher
    ..In this region we have identified a cAMP-response element (CRE) located at -99 to -92 and a Sp1-binding site at -145 to -135 that play a critical role in regulating basal activity of human SNF2L gene, which were ..
  49. Vallian S, Chin K, Chang K. The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoter. Mol Cell Biol. 1998;18:7147-56 pubmed
    ..gene promoter, we have now shown that PML's repression of EGFR transcription is caused by inhibition of EGFR's Sp1-dependent activity...
  50. Rohr O, Schwartz C, Hery C, Aunis D, Tardieu M, Schaeffer E. The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells. J Biol Chem. 2000;275:2654-60 pubmed
    ..The combination of COUP-TF and Tat leads to NF-kappaB- and Sp1-independent enhanced transcriptional stimulation...
  51. Ma Z, Chang M, Shah R, Adamski J, Zhao X, Benveniste E. Brg-1 is required for maximal transcription of the human matrix metalloproteinase-2 gene. J Biol Chem. 2004;279:46326-34 pubmed
    ..The transcription factors Sp1, Sp3, and AP-2 are required for constitutive expression of MMP-2 in tumor cells; however, the regulatory mechanisms ..
  52. Prasanna Kumar S, Thippeswamy G, Sheela M, Prabhakar B, Salimath B. Butyrate-induced phosphatase regulates VEGF and angiogenesis via Sp1. Arch Biochem Biophys. 2008;478:85-95 pubmed publisher
    b>Sp1 is a ubiquitous transcription factor and master regulator of various eukaryotic gene expression...
  53. Parks C, Shenk T. The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. J Biol Chem. 1996;271:4417-30 pubmed
    ..Three of the four MAZ binding sites also were shown to interact with transcription factor Sp1. Overproduction of MAZ or Sp1 in transient transfection assays increased expression directed by the human ..
  54. Fernández Alvarez A, Tur G, López Rodas G, Casado M. Reciprocal regulation of the human sterol regulatory element binding protein (SREBP)-1a promoter by Sp1 and EGR-1 transcription factors. FEBS Lett. 2008;582:177-84 pubmed
    ..start site where we discovered a functional role for the 3 GC-boxes containing overlapping sites for the Sp1 and EGR-1 transcription factors...
  55. Chuang J, Wang Y, Yeh S, Liu Y, Chang W, Hung J. Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis. Mol Biol Cell. 2008;19:1139-51 pubmed publisher
    The transcription factor Sp1 is ubiquitously expressed in different cells and thereby regulates the expression of genes involved in many cellular processes...
  56. De Siervi A, Marinissen M, Diggs J, Wang X, Pages G, Senderowicz A. Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1. Cancer Res. 2004;64:743-50 pubmed
    ..The minimal p21 promoter region required for perifosine-induced p21 promoter activation contains four consensus Sp1-binding sites. Mutations in each particular Sp1 site block perifosine-induced p21(waf1/cip1) expression...
  57. Lee D, Suh D, Edenberg H, Hur M. POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1. J Biol Chem. 2002;277:26761-8 pubmed
    ..transcription factor, FBI-1, that recognizes the cis-element (bp -38 to -22) located just upstream of the core Sp1 binding sites (bp -22 to +22) of the ADH5/FDH minimal promoter (bp -38 to +61) in vitro and in vivo, as revealed by ..
  58. Koutsodontis G, Vasilaki E, Chou W, Papakosta P, Kardassis D. Physical and functional interactions between members of the tumour suppressor p53 and the Sp families of transcription factors: importance for the regulation of genes involved in cell-cycle arrest and apoptosis. Biochem J. 2005;389:443-55 pubmed
    ..We found that Sp1 and Sp3, but not Sp2, co-operate functionally with p53, p73 and p63 for the synergistic transactivation of the ..
  59. Piera Velazquez S, Hawkins D, Whitecavage M, Colter D, Stokes D, Jimenez S. Regulation of the human SOX9 promoter by Sp1 and CREB. Exp Cell Res. 2007;313:1069-79 pubmed
    ..the human SOX9 proximal promoter is also regulated by the cyclic-AMP response element binding protein (CREB) and Sp1. We show by DNaseI protection and EMSA analysis that CREB and Sp1 interact with specific sites within the SOX9 ..
  60. Al Sarraj A, Day R, Thiel G. Specificity of transcriptional regulation by the zinc finger transcription factors Sp1, Sp3, and Egr-1. J Cell Biochem. 2005;94:153-67 pubmed
    The transcription factors Sp1, Sp3, and Egr-1 bind with their zinc finger DNA-binding domains to GC-rich sequences in the regulatory regions of their target genes...
  61. Plaisance V, Niederhauser G, Azzouz F, Lenain V, Haefliger J, Waeber G, et al. The repressor element silencing transcription factor (REST)-mediated transcriptional repression requires the inhibition of Sp1. J Biol Chem. 2005;280:401-7 pubmed
    ..Herein, we showed that the transcriptional factor Sp1 was required for expression of most REST target genes both in insulin-secreting cells and neuronal-like cells where ..
  62. Lin S, Black A, Kostic D, Pajovic S, Hoover C, Azizkhan J. Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. Mol Cell Biol. 1996;16:1668-75 pubmed
    Because of the large number of growth-regulated genes containing binding sites for the transcription factors Sp1 and E2F and the reported ability of E2F to mediate cell cycle (growth) regulation, we studied interactions between E2F1 and ..
  63. Jiang G, Espeseth A, Hazuda D, Margolis D. c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter. J Virol. 2007;81:10914-23 pubmed
    ..Sequential ChIP assays demonstrated that c-Myc, Sp1, and HDAC1 coexist in the same DNA-protein complex at the HIV promoter...
  64. Porée B, Kypriotou M, Chadjichristos C, Beauchef G, Renard E, Legendre F, et al. Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter. J Biol Chem. 2008;283:4850-65 pubmed
    ..The cytokine and/or sIL-6R repress COL2A1 transcription by a -63/-35 sequence that binds Sp1.Sp3. Indeed, IL-6 and/or sIL-6R inhibit Sp1 and Sp3 expression and their binding activity to the 63-bp promoter...
  65. Courey A, Holtzman D, Jackson S, Tjian R. Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Cell. 1989;59:827-36 pubmed
    We have examined the role of protein-protein interactions in modulating the activity of Sp1, a human transcription factor that utilizes glutamine-rich activation domains...
  66. Dunah A, Jeong H, Griffin A, Kim Y, Standaert D, Hersch S, et al. Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. Science. 2002;296:2238-43 pubmed
    ..Here, we report that huntingtin interacts with the transcriptional activator Sp1 and coactivator TAFII130...
  67. Armstrong S, Barry D, Leggett R, Mueller C. Casein kinase II-mediated phosphorylation of the C terminus of Sp1 decreases its DNA binding activity. J Biol Chem. 1997;272:13489-95 pubmed
    We have previously observed that Sp1, a ubiquitous zinc finger transcription factor, is phosphorylated during terminal differentiation in the whole animal, and this results in decreased DNA binding activity (Leggett, R. W., Armstrong, S...
  68. Wang L, Mukherjee S, Jia F, Narayan O, Zhao L. Interaction of virion protein Vpr of human immunodeficiency virus type 1 with cellular transcription factor Sp1 and trans-activation of viral long terminal repeat. J Biol Chem. 1995;270:25564-9 pubmed
    ..a minimal promoter from HIV-1 LTR containing the TATA box and binding motifs for the ubiquitous cellular transcription factor Sp1. Evidence is presented that Vpr interacts with Sp1 when Sp1 is bound to the Sp1 motifs within the HIV-1 ..