SOX8

Summary

Gene Symbol: SOX8
Description: SRY-box 8
Alias: transcription factor SOX-8, SRY (sex determining region Y)-box 8
Species: human
Products:     SOX8

Top Publications

  1. Schepers G, Wilson M, Wilhelm D, Koopman P. SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro. J Biol Chem. 2003;278:28101-8 pubmed
    b>Sox8 is a member of the Sox family of developmental transcription factor genes and is closely related to Sox9, a key gene in the testis determination pathway in mammals...
  2. Lefebvre V. Roles and regulation of SOX transcription factors in skeletogenesis. Curr Top Dev Biol. 2019;133:171-193 pubmed publisher
    ..that SOX4 and SOX11 (SOXC group) promote skeletal progenitor survival and control skeleton patterning and growth; SOX8 (SOXE group) delays the differentiation of osteoblast progenitors; SOX9 (SOXE group) is essential for chondrocyte ..
  3. Grimm D, Bauer J, Wise P, Kruger M, Simonsen U, Wehland M, et al. The role of SOX family members in solid tumours and metastasis. Semin Cancer Biol. 2019;: pubmed publisher
    ..SOX2, SOX4, SOX5, SOX8, SOX9, and SOX18 are up-regulated in different cancer types and have been found to be associated with poor ..
  4. Kimura S, Kobayashi N, Nakamura Y, Kanaya T, Takahashi D, Fujiki R, et al. Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice. J Exp Med. 2019;216:831-846 pubmed publisher
    ..Here, we demonstrate that Sox8, a member of the SRY-related HMG box transcription factor family, is specifically expressed by M cells in the ..
  5. Domingos J, Budd A, Banh Q, Goldsbury J, Zenger K, Jerry D. Sex-specific dmrt1 and cyp19a1 methylation and alternative splicing in gonads of the protandrous hermaphrodite barramundi. PLoS ONE. 2018;13:e0204182 pubmed publisher
    ..CpG sites within proximal promoters and first exons of seven sex-related genes (dmrt1, cyp19a1, amh, foxl2, nr5a2, sox8 and sox9) of 24 testis and 18 ovaries of captive and wild adult barramundi...
  6. Roumaud P, Martin L. Transcriptomic analysis of overexpressed SOX4 and SOX8 in TM4 Sertoli cells with emphasis on cell-to-cell interactions. Biochem Biophys Res Commun. 2019;512:678-683 pubmed publisher
    ..The transcription factor SOX8 is necessary for the maintenance of spermatogenesis during adult life whereas SOX4 is involved in developmental ..
  7. Portnoi M, Dumargne M, Rojo S, Witchel S, Duncan A, Eozenou C, et al. Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomalies. Hum Mol Genet. 2018;27:1228-1240 pubmed publisher
    b>SOX8 is an HMG-box transcription factor closely related to SRY and SOX9. Deletion of the gene encoding Sox8 in mice causes reproductive dysfunction but the role of SOX8 in humans is unknown...
  8. Lakiza O, Miller S, Bunce A, Lee E, McCauley D. SoxE gene duplication and development of the lamprey branchial skeleton: Insights into development and evolution of the neural crest. Dev Biol. 2011;359:149-161 pubmed publisher
    ..Three members (Sox8, Sox9, Sox10) are expressed in the neural crest and are thought to modulate the expression and activity of each ..
  9. Chen B, Tang H, Chen X, Zhang G, Wang Y, Xie X, et al. Transcriptomic analyses identify key differentially expressed genes and clinical outcomes between triple-negative and non-triple-negative breast cancer. Cancer Manag Res. 2019;11:179-190 pubmed publisher
    ..Only 16 genes were upregulated when further screened for fold change >4-fold change. HORMAD1 and SOX8 exhibited high frequencies of change of greater than 10% (HORMAD1 was close to 20%)...

More Information

Publications56

  1. Okamoto Y, Nishimura N, Matsuda K, Ranawakage D, Kamachi Y, Kondoh H, et al. Cooperation of Sall4 and Sox8 transcription factors in the regulation of the chicken Sox3 gene during otic placode development. Dev Growth Differ. 2018;60:133-145 pubmed publisher
    ..The Otic1 core octamer was activated by the combined action of Sall4 and the SoxE transcription factors (TFs) Sox8 or Sox9...
  2. Matsukawa S, Miwata K, Asashima M, Michiue T. The requirement of histone modification by PRDM12 and Kdm4a for the development of pre-placodal ectoderm and neural crest in Xenopus. Dev Biol. 2015;399:164-176 pubmed publisher
    ..indicated that PRDM12 promoted the occupancy of the trimethylated histone H3K9 (H3K9me3) on the Foxd3, Slug, and Sox8 promoters...
  3. Castelo Branco G, Lilja T, Wallenborg K, Falcão A, Marques S, Gracias A, et al. Neural stem cell differentiation is dictated by distinct actions of nuclear receptor corepressors and histone deacetylases. Stem Cell Reports. 2014;3:502-15 pubmed publisher
    ..resulted in increased expression of oligodendrocyte genes, revealing a direct HDAC2-mediated repression of Sox8 and Sox10 expression...
  4. Hong C, Saint Jeannet J. The b-HLH transcription factor Hes3 participates in neural plate border formation by interfering with Wnt/?-catenin signaling. Dev Biol. 2018;442:162-172 pubmed publisher
    ..Hes3 mis-expression at early neurula stage blocks neural crest (snai2, sox8, sox9 and sox10) and cranial placode (six1 and dmrta1) gene expression, and promotes neural plate (sox2 and sox3) ..
  5. Jeong Y, Lu H, Park C, Li M, Luo H, Kim J, et al. Stochastic anomaly of methylome but persistent SRY hypermethylation in disorder of sex development in canine somatic cell nuclear transfer. Sci Rep. 2016;6:31088 pubmed publisher
    ..was further correlated with silencing of a serial of testis determining genes, including SOX9, SF1, SOX8, AMH and DMRT1 in an early embryonic development stage at E34 in the XY(DSD) gonad, and high activation of the ..
  6. Guo B, Greenwood P, Cafe L, Zhou G, Zhang W, Dalrymple B. Transcriptome analysis of cattle muscle identifies potential markers for skeletal muscle growth rate and major cell types. BMC Genomics. 2015;16:177 pubmed publisher
    ..However, some exceptions were identified: expression of SOX8 previously attributed to muscle satellite cells was correlated with angiogenesis...
  7. Otake T, Kuroiwa A. Molecular mechanism of male differentiation is conserved in the SRY-absent mammal, Tokudaia osimensis. Sci Rep. 2016;6:32874 pubmed publisher
    ..After the initiation of testis differentiation, SOX9 enhances Amh expression by binding to its promoter with SF1. SOX8, SOX9 and SOX10, members of the SOXE gene family, also enhance the activities of the Amh promoter and TESCO...
  8. de Barros Mendes Lopes T, Groth E, Veras M, Furuya T, de Souza Xavier Costa N, Ribeiro Júnior G, et al. Pre- and postnatal exposure of mice to concentrated urban PM2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life. Environ Pollut. 2018;241:511-520 pubmed publisher
    ..A differential expression was validated at E14.5 for the candidates Sox8, Angptl4 and Gas1...
  9. Umeda K, Oda H, Yan Q, Matthias N, Zhao J, Davis B, et al. Long-term expandable SOX9+ chondrogenic ectomesenchymal cells from human pluripotent stem cells. Stem Cell Reports. 2015;4:712-26 pubmed publisher
    ..SOX4/12, LIN28A/B), cranial mesenchyme (ALX1/3/4), and chondroprogenitors (SOX9, COL2A1) of neural crest origin (SOX8/9, NGFR, NES). Ectomesenchyme is a source of many craniofacial bone and cartilage structures...
  10. Lindeman R, Gearhart M, Minkina A, Krentz A, Bardwell V, Zarkower D. Sexual cell-fate reprogramming in the ovary by DMRT1. Curr Biol. 2015;25:764-771 pubmed publisher
    ..DMRT1 can silence Foxl2 even in the absence of the testis-determining genes Sox8 and Sox9...
  11. Lee Y, Saint Jeannet J. Characterization of molecular markers to assess cardiac cushions formation in Xenopus. Dev Dyn. 2009;238:3257-65 pubmed publisher
    ..Among these genes, the Wnt antagonist Frzb1 and the transcription factors Xl-Fli, Sox8, Sox9, and Sox10 are differentially expressed in the mesenchyme of the OFT and AV cushions...
  12. Nishimura N, Ueharu H, Nishihara H, Shibuya S, Yoshida S, Higuchi M, et al. Search for regulatory factors of the pituitary-specific transcription factor PROP1 gene. J Reprod Dev. 2016;62:93-102 pubmed publisher
    ..the 3 kb upstream regions in CHO cells ultimately revealed that 8 factors, MSX2, PAX6, PIT1, PITX1, PITX2, RPF1, SOX8 and SOX11, but not RBP-J, regulate Prop1 expression...
  13. Huang Y, Jankowski A, Cheah K, Prabhakar S, Jauch R. SOXE transcription factors form selective dimers on non-compact DNA motifs through multifaceted interactions between dimerization and high-mobility group domains. Sci Rep. 2015;5:10398 pubmed publisher
    The SOXE transcription factors SOX8, SOX9 and SOX10 are master regulators of mammalian development directing sex determination, gliogenesis, pancreas specification and neural crest development...
  14. Weider M, Wegner M. SoxE factors: Transcriptional regulators of neural differentiation and nervous system development. Semin Cell Dev Biol. 2017;63:35-42 pubmed publisher
    b>Sox8, Sox9 and Sox10 represent the three vertebrate members of the SoxE subclass of high-mobility-group domain containing Sox transcription factors...
  15. Lee E, Yuan T, Ballim R, Nguyen K, Kelsh R, Medeiros D, et al. Functional constraints on SoxE proteins in neural crest development: The importance of differential expression for evolution of protein activity. Dev Biol. 2016;418:166-178 pubmed publisher
    Vertebrate SoxE genes (Sox8, 9, and 10) are key regulators of neural crest cell (NCC) development. These genes arose by duplication from a single SoxE gene in the vertebrate ancestor...
  16. Roumaud P, Haché J, Martin L. Expression profiles of Sox transcription factors within the postnatal rodent testes. Mol Cell Biochem. 2018;447:175-187 pubmed publisher
    ..known to play an important role in sex determination (Sry, Sox9), male gonadal development, and fertility (Sox4, Sox8, Sox30). However, their expression profiles per cell types remain elusive...
  17. Gong L, Xu H, Guo G, Zhang T, Shi J, Chang C. Long Non-Coding RNA H19 Protects H9c2 Cells against Hypoxia-Induced Injury by Targeting MicroRNA-139. Cell Physiol Biochem. 2017;44:857-869 pubmed publisher
    ..of non-physiologically expressed H19, knockdown of miR-139 with or without H19 silence, and abnormally expressed Sox8 on hypoxia-induced H9c2 cells...
  18. Merchan Sala P, Nardini D, Waclaw R, Campbell K. Selective neuronal expression of the SoxE factor, Sox8, in direct pathway striatal projection neurons of the developing mouse brain. J Comp Neurol. 2017;525:2805-2819 pubmed publisher
    ..We show here that the SoxE family member, Sox8, is co-expressed with the dSPN markers, Isl1 and Ebf1, in the developing striatum...
  19. de Melo J, Zibetti C, Clark B, Hwang W, Miranda Angulo A, Qian J, et al. Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling. J Neurosci. 2016;36:2391-405 pubmed publisher
    ..of Notch pathway genes including Notch1, Dll1, and Dll3 and gliogenic transcription factors such as Hes1, Hes5, Sox8, and Rax...
  20. Barrionuevo F, Hurtado A, Kim G, Real F, Bakkali M, Kopp J, et al. Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration. elife. 2016;5: pubmed publisher
    ..Sox9 and Sox8 are required for postnatal male fertility, but their role in the adult testis has not been investigated...
  21. Yang H, Zhang Z, Xue L. Structural Characterization and Functional Analysis of the Follistatin Promoter of Larimichthys crocea. DNA Cell Biol. 2016;35:471-9 pubmed publisher
    ..To study the regulation of follistatin expression in L. crocea, we cloned MyoD and SRY-box 8 (Sox8) genes and examined their action on the follistatin promoter by co-transfection in CIK and L6 cells...
  22. Kataruka S, Akhade V, Kayyar B, Rao M. Mrhl Long Noncoding RNA Mediates Meiotic Commitment of Mouse Spermatogonial Cells by Regulating Sox8 Expression. Mol Cell Biol. 2017;37: pubmed publisher
    ..In our present study, we identified the transcription factor Sox8 as the regulatory link between mrhl RNA expression, Wnt signaling activation, and meiotic progression...
  23. Kawasaki K, Kawasaki M, Watanabe M, Idrus E, Nagai T, Oommen S, et al. Expression of Sox genes in tooth development. Int J Dev Biol. 2015;59:471-8 pubmed publisher
    ..Sox13 showed restricted expression in the primary enamel knots. At the early bell stage, three Sox genes (Sox8, 11, 17 and 21) were expressed in pre-ameloblasts, whereas two others (Sox5 and 18) showed expression in ..
  24. Nicol B, Yao H. Gonadal Identity in the Absence of Pro-Testis Factor SOX9 and Pro-Ovary Factor Beta-Catenin in Mice. Biol Reprod. 2015;93:35 pubmed publisher
    ..underlying the XY-specific masculinization involve the expression of Sry and 21 SRY direct target genes, such as Sox8 and Cyp26b1...
  25. de Melo J, Clark B, Blackshaw S. Multiple intrinsic factors act in concert with Lhx2 to direct retinal gliogenesis. Sci Rep. 2016;6:32757 pubmed publisher
    ..Finally, Sox2, Sox8, and Sox9 promoted amacrine cell formation in Lhx2-deficient cells, but not in wildtype retinas...
  26. Chen S, Liu Y. Testis Cord Maintenance in Mouse Embryos: Genes and Signaling. Biol Reprod. 2016;94:42 pubmed publisher
    ..the regulation of testis cord integrity by a series of Sertoli cell transcription factors, including the WT1-SOX8/SOX9-beta-CATENIN-DHH network, GPR56, STIM1, and NR0B1 (also known as DAX1)...
  27. Wang B, Qi T, Chen S, Ye L, Huang Z, Li H. RFX1 maintains testis cord integrity by regulating the expression of Itga6 in male mouse embryos. Mol Reprod Dev. 2016;83:606-14 pubmed publisher
    ..At least five genes (Wt1, Dhh, Sox8/Sox9, and Dax1) appear to be required for the maintenance of testis cord integrity in mice...
  28. Cheng Y, Lee C, Badge R, Orme A, Scotting P. Sox8 gene expression identifies immature glial cells in developing cerebellum and cerebellar tumours. Brain Res Mol Brain Res. 2001;92:193-200 pubmed
    b>Sox8 is a member of the E subgroup of Sox genes, the other members of which are Sox9 and Sox10, both of which are implicated in specific human disorders...
  29. Murko C, Bronner M. Tissue specific regulation of the chick Sox10E1 enhancer by different Sox family members. Dev Biol. 2017;422:47-57 pubmed publisher
    ..Loss-of-function experiments reveal Sox5 and Sox8 as critical inputs for trunk neural crest enhancer activity, but only Sox8 for its activity in the ear...
  30. Portela Bens S, Merlo M, Rodríguez M, Cross I, Manchado M, Kosyakova N, et al. Integrated gene mapping and synteny studies give insights into the evolution of a sex proto-chromosome in Solea senegalensis. Chromosoma. 2017;126:261-277 pubmed publisher
    ..BAC) clones that contain candidate genes involved in such processes (dmrt1, dmrt2, dmrt3, dmrt4, sox3, sox6, sox8, sox9, lh, cyp19a1a, amh, vasa, aqp3, and nanos3) were analyzed and compared with the same region in other related ..
  31. Wapinski O, Lee Q, Chen A, Li R, Corces M, Ang C, et al. Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons. Cell Rep. 2017;20:3236-3247 pubmed publisher
    ..changes, we built a network model of dynamic TF regulation during iN cell reprogramming and identified Zfp238, Sox8, and Dlx3 as key TFs downstream of Ascl1...
  32. Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Res. 2006;34:1735-44 pubmed
    ..this study, yeast two-hybrid screens identified transcription factors as a major group of interacting proteins for Sox8 and Sox10...
  33. Turnescu T, Arter J, Reiprich S, Tamm E, Waisman A, Wegner M. Sox8 and Sox10 jointly maintain myelin gene expression in oligodendrocytes. Glia. 2018;66:279-294 pubmed publisher
    ..As Sox10 is co-expressed with the related Sox8, we also analyzed oligodendrocytes and myelination in Sox8-deficient mice...
  34. Lill C, Schjeide B, Graetz C, Ban M, Alcina A, Ortiz M, et al. MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis. Brain. 2013;136:1778-82 pubmed publisher
    ..We tested five single nucleotide polymorphisms rs228614 (MANBA), rs630923 (CXCR5), rs2744148 (SOX8), rs180515 (RPS6KB1), and rs6062314 (ZBTB46) for association with multiple sclerosis risk in a total of 8499 cases ..
  35. Xie S, Fan S, Zhang S, Chen W, Li Q, Pan G, et al. SOX8 regulates cancer stem-like properties and cisplatin-induced EMT in tongue squamous cell carcinoma by acting on the Wnt/β-catenin pathway. Int J Cancer. 2018;142:1252-1265 pubmed publisher
    ..In our study, we explored the role of SOX8 and its molecular mechanism in the regulation of the stemness properties and the epithelial mesenchymal transition (..
  36. Bezerra M, Araújo A, Phylipsen M, Balak D, Kimura E, Oliveira D, et al. The deletion of SOX8 is not associated with ATR-16 in an HbH family from Brazil. Br J Haematol. 2008;142:324-6 pubmed publisher
  37. Nonaka D. Differential expression of SOX2 and SOX17 in testicular germ cell tumors. Am J Clin Pathol. 2009;131:731-6 pubmed publisher
    ..Choriocarcinomas were negative for SOX2 and SOX17. SOX2 and SOX17 expression patterns can distinguish between seminoma and embryonal carcinoma, and this distinction may be diagnostically useful...
  38. Pfeifer D, Poulat F, Holinski Feder E, Kooy F, Scherer G. The SOX8 gene is located within 700 kb of the tip of chromosome 16p and is deleted in a patient with ATR-16 syndrome. Genomics. 2000;63:108-16 pubmed
    ..We describe the 5. 4-kb human SOX8 gene that codes for a 446-amino-acid protein and that is expressed strongly in brain and less abundantly in other ..
  39. Xie C, Han Y, Liu Y, Han L, Liu J. miRNA-124 down-regulates SOX8 expression and suppresses cell proliferation in non-small cell lung cancer. Int J Clin Exp Pathol. 2014;7:6534-42 pubmed
    ..Our study aimed to investigate the expression of SOX8, a protein belonging to the E group of the SOX family, as well as SOX9, in non-small cell lung cancer (NSCLC) and ..
  40. Zhang S, Zhu C, Zhu L, Liu H, Liu S, Zhao N, et al. Oncogenicity of the transcription factor SOX8 in hepatocellular carcinoma. Med Oncol. 2014;31:918 pubmed publisher
    ..We found by qRT-PCR analysis and immunohistochemistry that the gene SOX8 was significantly upregulated in HCC...
  41. Liu M, Xu P, Guan Z, Qian X, Dockery P, FitzGerald U, et al. Ulk4 deficiency leads to hypomyelination in mice. Glia. 2018;66:175-190 pubmed publisher
    ..Major oligodendrogeneic transcription factors, including Olig2, Olig1, Myrf, Sox10, Sox8, Sox6, Sox17, Nkx2-2, Nkx6-2 and Carhsp1, are significantly downregulated in the mutants...
  42. Azar S, Leventoux N, Ripoll C, Rigau V, Goze C, Lorcy F, et al. Cellular and molecular characterization of IDH1-mutated diffuse low grade gliomas reveals tumor heterogeneity and absence of EGFR/PDGFR? activation. Glia. 2017;: pubmed publisher
    ..In oligodendrogliomas, cells express the transcription factors MYT1, Nkx2.2, Olig1, Olig2, Sox8, four receptors (EGFR, PDGFR?, LIFR, PTPRZ1) but not the co-receptor NG2 known to be expressed by oligodendrocyte ..
  43. Matsumoto A, Imagawa E, Miyake N, Ikeda T, Kobayashi M, Goto M, et al. The presence of diminished white matter and corpus callosal thinning in a case with a SOX9 mutation. Brain Dev. 2018;40:325-329 pubmed publisher
    ..is thought to be crucial in neural stem cell development in the central and peripheral nervous system along with Sox8 and Sox10 in mice...
  44. Ornat M, Kobierzycki C, Grzegrzolka J, Pula B, Zamirska A, Bieniek A, et al. SOX18 Expression in Non-melanoma Skin Cancer. Anticancer Res. 2016;36:2379-83 pubmed
    ..SOX18 may play a role in the development of BCC and SCC. Further studies with the use of additional markers tested at the mRNA and protein level are necessary for better explanation of SOX18 function in cancer transformation. ..
  45. Schepers G, Bullejos M, Hosking B, Koopman P. Cloning and characterisation of the Sry-related transcription factor gene Sox8. Nucleic Acids Res. 2000;28:1473-80 pubmed
    ..Several SOX genes have been implicated in human congenital diseases. We report here the isolation of Sox8 and its characterisation in mice and humans...
  46. Herlofsen S, Høiby T, Cacchiarelli D, Zhang X, Mikkelsen T, Brinchmann J. Brief report: importance of SOX8 for in vitro chondrogenic differentiation of human mesenchymal stromal cells. Stem Cells. 2014;32:1629-35 pubmed publisher
    The transcription factor SOX9 is believed to be the master regulator of chondrogenesis. SOX8 is another SOX group E transcription factor with a high degree of homology to SOX9...
  47. Hoff S, Zeller F, Von Weyhern C, Wegner M, Schemann M, Michel K, et al. Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody. J Comp Neurol. 2008;509:356-71 pubmed publisher
    ..with antibodies against S100b, glial fibrillary acidic protein (GFAP), and p75NGFR and the transcription factors Sox8/9/10 and neuronally counterstained...