SOX3

Summary

Gene Symbol: SOX3
Description: SRY-box 3
Alias: GHDX, MRGH, PHP, PHPX, SOXB, transcription factor SOX-3, SRY (sex determining region Y)-box 3
Species: human
Products:     SOX3

Top Publications

  1. Collignon J, Sockanathan S, Hacker A, Cohen Tannoudji M, Norris D, Rastan S, et al. A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development. 1996;122:509-20 pubmed
    ..However our findings imply that if this is true, then Sry has undergone concomitant changes resulting in loss of CNS expression and altered DNA-binding properties. ..
  2. Krstic A, Mojsin M, Stevanovic M. Regulation of SOX3 gene expression is driven by multiple NF-Y binding elements. Arch Biochem Biophys. 2007;467:163-73 pubmed
    The presented results demonstrate that human SOX3 promoter possesses three CCAAT box control elements involved in the regulation of SOX3 gene expression in NT2/D1 cells...
  3. Stevanovic M, Lovell Badge R, Collignon J, Goodfellow P. SOX3 is an X-linked gene related to SRY. Hum Mol Genet. 1993;2:2013-8 pubmed
    ..These genes have been named SOX genes (SRY-related HMG-box genes). We have cloned and characterised SOX3, a member of the human SOX gene family. SOX3 maps to the X chromosome in the region Xq26-27...
  4. Mojsin M, Grujicić N, Nikcevic G, Krstic A, Savić T, Stevanovic M. Mapping of the RXRalpha binding elements involved in retinoic acid induced transcriptional activation of the human SOX3 gene. Neurosci Res. 2006;56:409-18 pubmed
    b>Sox3/SOX3 gene is implicated in the control of nervous system development and is considered to be one of the earliest neural markers...
  5. Mojsin M, Stevanovic M. PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region. Biochem J. 2009;425:107-16 pubmed publisher
    b>Sox3/SOX3 [SRY (sex determining region Y)-box 3] is considered to be one of the earliest neural markers in vertebrates, playing a role in specifying neuronal fate...
  6. Ducluzeau A, Schoepp Cothenet B, van Lis R, Baymann F, Russell M, Nitschke W. The evolution of respiratory O2/NO reductases: an out-of-the-phylogenetic-box perspective. J R Soc Interface. 2014;11:20140196 pubmed publisher
    ..data, sees the low O2-affinity SoxM- (or A-) type enzymes as the most recent evolutionary innovation and the high-affinity O2 reductases (SoxB or B and cbb3 or C) as arising independently from NO-reducing precursor enzymes.
  7. Paese C, Schoenauer A, Leite D, Russell S, McGregor A. A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider. elife. 2018;7: pubmed publisher
    ..In insects, the SoxB gene Dichaete is the only Sox gene known to be involved in segmentation...
  8. Hong Q, Li C, Ying R, Lin H, Li J, Zhao Y, et al. Loss-of-function of sox3 causes follicle development retardation and reduces fecundity in zebrafish. Protein Cell. 2019;10:347-364 pubmed publisher
    ..Here, we generated sox3 knockout zebrafish lines using CRISPR/Cas9...
  9. Takamiya M, Weger B, Schindler S, Beil T, Yang L, Armant O, et al. Molecular description of eye defects in the zebrafish Pax6b mutant, sunrise, reveals a Pax6b-dependent genetic network in the developing anterior chamber. PLoS ONE. 2015;10:e0117645 pubmed publisher
    ..pax6b mutants show loss of corneal epithelial gene expression including regulatory genes (sox3, tfap2a, foxc1a and pitx2)...

More Information

Publications127 found, 100 shown here

  1. Focareta L, Cole A. Analyses of Sox-B and Sox-E Family Genes in the Cephalopod Sepia officinalis: Revealing the Conserved and the Unusual. PLoS ONE. 2016;11:e0157821 pubmed publisher
    ..b>SoxB proteins are widely known for their role in neural specification in numerous phylogenetic lineages...
  2. Whitworth D, Limnios I, Gauthier M, Weeratunga P, Ovchinnikov D, Baillie G, et al. Platypus Induced Pluripotent Stem Cells: the Unique Pluripotency Signature of a Monotreme. Stem Cells Dev. 2018;: pubmed publisher
    ..Given the more extensive role of SOX3 over SOX2 in avian pluripotency, our data indicate that between 315 million years and 166 million years ago ..
  3. Duan J, Flock K, Jue N, Zhang M, Jones A, Seesi S, et al. Dosage Compensation and Gene Expression of the X Chromosome in Sheep. G3 (Bethesda). 2019;9:305-314 pubmed publisher
    ..nutrition, however, did change expression levels of several X-linked genes, such as sex determination genes SOX3 and NR0B1 In summary, our results showed that X chromosome upregulation occurred in nearly all sheep ..
  4. Fei J, Schuez M, Tazaki A, Taniguchi Y, Roensch K, Tanaka E. CRISPR-mediated genomic deletion of Sox2 in the axolotl shows a requirement in spinal cord neural stem cell amplification during tail regeneration. Stem Cell Reports. 2014;3:444-59 pubmed publisher
    ..In contrast, the mesodermal blastema formed normally. Sox3 expression during development, but not regeneration, most likely allowed embryonic survival and the regeneration-..
  5. Araújo F, Milsted A, Watanabe I, Del Puerto H, Santos R, Lazar J, et al. Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters. Physiol Genomics. 2015;47:177-86 pubmed publisher
    ..in rat were used to address if regulation of Sry on the RAS is conserved in the homologous X-chromosome gene, Sox3. Both SRY and SOX3 upregulated the promoter of Angiotensinogen (AGT) and downregulated the promoters of ACE2, AT2, ..
  6. Richards G, Rentzsch F. Transgenic analysis of a SoxB gene reveals neural progenitor cells in the cnidarian Nematostella vectensis. Development. 2014;141:4681-9 pubmed publisher
    ..Using a transgenic reporter line, we show that NvSoxB(2) - an orthologue of bilaterian SoxB genes that have conserved roles in neurogenesis - is expressed in a cell population that gives rise to sensory ..
  7. Vidovic D, Harris L, Harvey T, Evelyn Heng Y, Smith A, Osinski J, et al. Expansion of the lateral ventricles and ependymal deficits underlie the hydrocephalus evident in mice lacking the transcription factor NFIX. Brain Res. 2015;1616:71-87 pubmed publisher
    ..b>SOX3 is a factor known to regulate SCO development...
  8. Yu T, Chang G, Cheng Q, Yao R, Li J, Xu Y, et al. Increased transactivation and impaired repression of β-catenin-mediated transcription associated with a novel SOX3 missense mutation in an X-linked hypopituitarism pedigree with modest growth failure. Mol Cell Endocrinol. 2018;478:133-140 pubmed publisher
    b>SOX3, a transcription factor of the SRY-related high mobility group box family, has been implicated in the etiology of X-linked hypopituitarism. Here, we report a Chinese pedigree of X-linked hypopituitarism with variable phenotypes...
  9. Klum S, Zaouter C, Alekseenko Z, Björklund A, Hagey D, Ericson J, et al. Sequentially acting SOX proteins orchestrate astrocyte- and oligodendrocyte-specific gene expression. EMBO Rep. 2018;19: pubmed publisher
    ..glial gene sets are extensively preselected already in multipotent neural precursor cells through prebinding by SOX3. In the subsequent lineage-restricted glial precursor cells, astrocyte genes become additionally targeted by SOX9 ..
  10. Ernsberger U. Can the 'neuron theory' be complemented by a universal mechanism for generic neuronal differentiation. Cell Tissue Res. 2015;359:343-84 pubmed publisher
    ..Sox and, in particular, SoxB and SoxC proteins as well as basic helix-loop-helix proteins play major roles, even though their precise ..
  11. Imhoff J. New Dimensions in Microbial Ecology-Functional Genes in Studies to Unravel the Biodiversity and Role of Functional Microbial Groups in the Environment. Microorganisms. 2016;4: pubmed publisher
    ..purple bacteria, with genes of adenosine-5'phosphosulfate (APS) reductase (aprA), sulfate thioesterase (soxB) and dissimilatory sulfite reductase (dsrAB) for sulfur oxidizing and sulfate reducing bacteria, with genes of ..
  12. McAninch D, Thomas P. Identification of highly conserved putative developmental enhancers bound by SOX3 in neural progenitors using ChIP-Seq. PLoS ONE. 2014;9:e113361 pubmed publisher
    The transcription factor SOX3 is expressed within most neural progenitor (NP) cells of the vertebrate central nervous system (CNS) and is essential for normal brain development in mice and humans...
  13. Heenan P, Zondag L, Wilson M. Evolution of the Sox gene family within the chordate phylum. Gene. 2016;575:385-392 pubmed publisher
    ..Using phylogenetic analysis we determined their evolutionary relationships. We propose that the last common ancestor of chordates had at least seven Sox genes, including the core suite of SoxB, C, D, E and F as well as SoxH.
  14. Monjo F, Romero R. Embryonic development of the nervous system in the planarian Schmidtea polychroa. Dev Biol. 2015;397:305-19 pubmed publisher
    ..we characterize embryonic neurogenesis in the freshwater flatworm Schmidtea polychroa and analyze the expression of soxB and a set of proneural bHLH genes, which are gene families with a well-established role in metazoan early neural ..
  15. Okamoto Y, Nishimura N, Matsuda K, Ranawakage D, Kamachi Y, Kondoh H, et al. Cooperation of Sall4 and Sox8 transcription factors in the regulation of the chicken Sox3 gene during otic placode development. Dev Growth Differ. 2018;60:133-145 pubmed publisher
    To elucidate the transcriptional regulation that underlies specification of the otic placode, we investigated the Sox3 downstream enhancer Otic1 of the chicken, the activity of which is restricted to and distributed across the entire otic ..
  16. Jasnic Savovic J, Klajn A, Milivojevic M, Mojsin M, Nikcevic G. Human embryonal carcinoma cells in serum-free conditions as an in vitro model system of neural differentiation. Altern Lab Anim. 2015;43:9-18 pubmed
    ..have previously shown that the early phases of neural induction of these cells by RA involve the up-regulation of SOX3 gene expression...
  17. Ray S, Ghosh S, Bagchi A. Molecular Interactions, Structural Transitions and Alterations in SoxB Protein Due to SoxYZ Interaction from Two Distinct β-Proteobacteria: An In silico Approach Towards the Thiosulfate Oxidation and Recycling of SoxY Protein. Interdiscip Sci. 2018;10:390-399 pubmed publisher
    ..However, the molecular details of the involvements of the essential SoxB, SoxY and SoxZ proteins in the beta-proteobacteria have not yet been elucidated...
  18. Salamon S, Flisikowski K, Switonski M. Methylation Patterns of SOX3, SOX9, and WNT4 Genes in Gonads of Dogs with XX (SRY-Negative) Disorder of Sexual Development. Sex Dev. 2017;11:86-93 pubmed publisher
    ..of our study was comparative methylation analysis of CpG islands in promoters of candidate genes for XX DSD: SOX9, SOX3, and WNT4...
  19. Wang C, Chen X, Shi W, Wang F, Du Z, Li X, et al. 2-Bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Neurotoxicol Teratol. 2015;50:53-63 pubmed publisher
    ..that the mRNA quantities and distributions of neural stem/progenitor cell (NSPC) markers (neurog1, sox2, and sox3) in the affected regions of 50 μM 2BP treated embryos significantly decreased...
  20. Li T, Wu Q, Zhang C, Li W, Zhou Q, Jiang W, et al. 46,XX testicular disorder of sexual development with SRY-negative caused by some unidentified mechanisms: a case report and review of the literature. BMC Urol. 2014;14:104 pubmed publisher
    ..No mutation was detected in the coding region and exon/intron boundaries of the RSPO1, DAX1, SOX9, SOX3, SOX10, ROCK1, and DMRT genes, and no copy number variation in the whole genome sequence was found...
  21. Corsinotti A, Wong F, Tatar T, Szczerbinska I, Halbritter F, Colby D, et al. Distinct SoxB1 networks are required for naïve and primed pluripotency. elife. 2017;6: pubmed publisher
    ..While this can be prevented by enforced expression of the related SOXB1 proteins, SOX1 or SOX3, the roles of SOXB1 proteins in epiblast stem cell (EpiSC) pluripotency are unknown...
  22. Sa J, Kim S, Lee J, Cho H, Shin Y, Shin H, et al. Identification of Genomic and Molecular Traits that Present Therapeutic Vulnerability to HGF-targeted therapy in Glioblastoma. Neuro Oncol. 2018;: pubmed publisher
    ..We have identified differentially expressed genes, including MET, KDR, and SOX3 which are associated with tumor invasiveness, malignancy, and unfavorable prognosis in glioblastoma patients...
  23. Keverne E. Genomic imprinting, action, and interaction of maternal and fetal genomes. Proc Natl Acad Sci U S A. 2015;112:6834-40 pubmed publisher
    ..SRY is a hybrid gene of Dgcr8 expressed in the developing placenta and Sox3 expressed in hypothalamic development...
  24. Purcell C, Seetharam A, Snodgrass O, Ortega García S, Hyde J, Severin A. Insights into teleost sex determination from the Seriola dorsalis genome assembly. BMC Genomics. 2018;19:31 pubmed publisher
    ..dorsalis involving a female-specific deletion of a transcription factor binding motif that may be targeted by Sox3. Understanding the mechanism of sex determination and development of assays to determine sex is critical both for ..
  25. Dominguez L, Schlosser G, Shen S. Expression of a novel serine/threonine kinase gene, Ulk4, in neural progenitors during Xenopus laevis forebrain development. Neuroscience. 2015;290:61-79 pubmed publisher
    ..We further combined in situ hybridization for xUlk4 with immunohistochemistry for the neural progenitor cell marker SOX3, the radial glial marker brain lipid-binding protein (BLBP), neuronal markers MAP2 and doublecortin (DCX) and the ..
  26. Hashemi M, Esfahani A, Peymani M, Nejati A, Ghaedi K, Nasr Esfahani M, et al. Zinc finger protein 521 overexpression increased transcript levels of Fndc5 in mouse embryonic stem cells. J Biosci. 2016;41:69-76 pubmed
    ..of neurogenesis in mouse embryonic stem cells through inducing expression of the early neuroectodermal genes Sox1, Sox3 and Pax6...
  27. Mandalos N, Remboutsika E. Sox2: To crest or not to crest?. Semin Cell Dev Biol. 2017;63:43-49 pubmed publisher
    ..In the neural progenitor pool, SoxB factors play an essential role as cell fate determinants of neural development, whereas during neural crest stem ..
  28. Muthusamy S, Baltar F, González J, Pinhassi J. Dynamics of metabolic activities and gene expression in the Roseobacter clade bacterium Phaeobacter sp. strain MED193 during growth with thiosulfate. Appl Environ Microbiol. 2014;80:6933-42 pubmed publisher
    ..The addition of thiosulfate enhanced the bacterial growth yields up to 40% in this strain. Concomitantly, soxB and soxY gene expression increased about 8-fold with thiosulfate and remained 11-fold higher than that in controls ..
  29. Marjanovic Vicentic J, Drakulic D, Garcia I, Vukovic V, Aldaz P, Puskas N, et al. SOX3 can promote the malignant behavior of glioblastoma cells. Cell Oncol (Dordr). 2019;42:41-54 pubmed publisher
    ..b>SOX3 plays a role in both normal neural development and carcinogenesis...
  30. Fritez N, Sobrier M, Iraqi H, Vié Luton M, Netchine I, El Annas A, et al. Molecular screening of a large cohort of Moroccan patients with congenital hypopituitarism. Clin Endocrinol (Oxf). 2015;82:876-84 pubmed publisher
    ..screened for molecular defects in GH1 (including LCR-GH1), GHRHR, GHSR, GHRH, PROP1, POU1F1, HESX1, LHX3, LHX4 and SOX3. Five different deleterious mutations were identified in 14 patients from eight families...
  31. Muñoz R, Edwards Faret G, Moreno M, Zuñiga N, Cline H, Larraín J. Regeneration of Xenopus laevis spinal cord requires Sox2/3 expressing cells. Dev Biol. 2015;408:229-43 pubmed publisher
    ..We found that cells expressing Sox2 and/or Sox3 are present in the ventricular zone of regenerative animals and decrease in non-regenerative froglets...
  32. Errichiello E, Gorgone C, Giuliano L, Iadarola B, Cosentino E, Rossato M, et al. SOX2: Not always eye malformations. Severe genital but no major ocular anomalies in a female patient with the recurrent c.70del20 variant. Eur J Med Genet. 2018;61:335-340 pubmed publisher
    ..Moreover, our case strengthens the role of SOX2 as a master regulator of female gonadal differentiation, as widely demonstrated for other SOX genes related to 46, XX sex reversal, such as SOX3 and SOX9.
  33. Whittington N, Cunningham D, Le T, De Maria D, Silva E. Sox21 regulates the progression of neuronal differentiation in a dose-dependent manner. Dev Biol. 2015;397:237-47 pubmed publisher
    Members of the SoxB transcription factor family play critical roles in the regulation of neurogenesis...
  34. Yin N, Liang S, Liang S, Hu B, Yang R, Zhou Q, et al. DEP and DBP induce cytotoxicity in mouse embryonic stem cells and abnormally enhance neural ectoderm development. Environ Pollut. 2018;236:21-32 pubmed publisher
    ..For instance, neural ectoderm markers, such as Pax6, Nestin, Sox1 and Sox3, were significantly up-regulated upon DEP and DBP exposure...
  35. Wang L, Hiler D, Xu B, Aldiri I, Chen X, Zhou X, et al. Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures. Cell Rep. 2018;22:2601-2614 pubmed publisher
    Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc...
  36. Wei P, Chao A, Peng H, Chao A, Chang Y, Chang S, et al. SOX9 as a Predictor for Neurogenesis Potentiality of Amniotic Fluid Stem Cells. Stem Cells Transl Med. 2014;3:1138-47 pubmed publisher
    ..In the discovery phase of 23 AFSCs, we tested ZNF521/Zfp521, OCT6, SOX1, SOX2, SOX3, and SOX9 as predictive markers of AFSCs for neural differentiation...
  37. Zhang S, Chen X, Wang M, Zhang W, Pan J, Qin Q, et al. Genome-wide identification, phylogeny and expressional profile of the Sox gene family in channel catfish (Ictalurus punctatus). Comp Biochem Physiol Part D Genomics Proteomics. 2018;28:17-26 pubmed publisher
    ..catfish genome and classified into seven families based on their conserved domains as follows: eight genes in SoxB group (six in SoxB1 subgroup and two in SoxB2 subgroup); five genes in SoxC group; three genes in SoxD and SoxF ..
  38. Vidal B, Santella A, Serrano Saiz E, Bao Z, Chuang C, Hobert O. C. elegans SoxB genes are dispensable for embryonic neurogenesis but required for terminal differentiation of specific neuron types. Development. 2015;142:2464-77 pubmed publisher
    ..Sox proteins and specifically members of the SoxB and SoxC groups are another class of conserved transcription factors with an important role in neuronal fate ..
  39. Giordano M. Genetic causes of isolated and combined pituitary hormone deficiency. Best Pract Res Clin Endocrinol Metab. 2016;30:679-691 pubmed publisher
    ..pathogenesis of IGHD whereas mutations in transcription factors such as HESX1, PROP1, POU1F1, LHX3, LHX4, GLI2 and SOX3 contributed to the understanding of CPHD...
  40. Su R, Cao S, Ma J, Liu Y, Liu X, Zheng J, et al. Knockdown of SOX2OT inhibits the malignant biological behaviors of glioblastoma stem cells via up-regulating the expression of miR-194-5p and miR-122. Mol Cancer. 2017;16:171 pubmed publisher
    ..Dual-luciferase reporter assay revealed that SOX2OT bound to both miR-194-5p and miR-122. SOX3 and TDGF-1 were up-regulated in human glioma tissues and GSCs...
  41. Li C, Liu H, Zhang B, Gong L, Su Y, Zhang Z, et al. Whole-exome sequencing identifies key mutated genes in T790M wildtype/cMET-unamplified lung adenocarcinoma with acquired resistance to first-generation EGFR tyrosine kinase inhibitors. J Cancer Res Clin Oncol. 2018;144:1079-1086 pubmed publisher
    ..white blood cells identified a cohort of candidate key mutated genes including BRAF, FGFR1, PAK1, PCNT, PEBP4 and SOX3. EGFR T790M mutation and cMET amplification are main mechanisms leading to EGFR TKI resistance in lung ..
  42. Hong C, Saint Jeannet J. The b-HLH transcription factor Hes3 participates in neural plate border formation by interfering with Wnt/?-catenin signaling. Dev Biol. 2018;442:162-172 pubmed publisher
    ..sox8, sox9 and sox10) and cranial placode (six1 and dmrta1) gene expression, and promotes neural plate (sox2 and sox3) fate...
  43. Anirudhan T, Binusreejayan -. Dextran based nanosized carrier for the controlled and targeted delivery of curcumin to liver cancer cells. Int J Biol Macromol. 2016;88:222-35 pubmed publisher
    ..In the present study, we mainly focus on synthesis and characterization of dextran based nano-sized drug carrier (GHDx) for the delivery of Cur...
  44. Chen C, Chen C, Chern S, Wu P, Chen Y, Chen S, et al. Molecular cytogenetic characterization of Xp22.32?pter deletion and Xq26.3?qter duplication in a male fetus associated with 46,Y,rec(X)dup(Xq) inv(X)(p22.3q26.3), a hypoplastic left heart, short stature, and maternal X chromosome pericentric inversio. Taiwan J Obstet Gynecol. 2016;55:705-711 pubmed publisher
    ..33-p22.32 encompassing SHOX, CSF2RA, and ARSE, and a 19.22-Mb duplication of Xq26.3-q28 encompassing SOX3, FMR1, MECP2, RAB39B, and CLIC2 in the fetus. The mother did not have X chromosome imbalance...
  45. Gou Y, Guo J, Maulding K, Riley B. sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish. Dev Biol. 2018;435:84-95 pubmed publisher
    Expression of sox3 is one of the earliest markers of Fgf-dependent otic/epibranchial placode induction. We report here that sox2 is also expressed in the early otic/epibranchial placode in zebrafish...
  46. Tosic N, Petrovic I, Grujicić N, Davidovic S, Virijevic M, Vukovic N, et al. Prognostic significance of SOX2, SOX3, SOX11, SOX14 and SOX18 gene expression in adult de novo acute myeloid leukemia. Leuk Res. 2018;67:32-38 pubmed publisher
    ..In this study we investigated SOX2, SOX3, SOX11, SOX14 and SOX18 gene expression in 50 de novo adult AML patients and correlated our findings with known ..
  47. Harrold Z, Skidmore M, Hamilton T, Desch L, Amada K, van Gelder W, et al. Aerobic and Anaerobic Thiosulfate Oxidation by a Cold-Adapted, Subglacial Chemoautotroph. Appl Environ Microbiol. 2015;82:1486-95 pubmed publisher
    ..1°C than 14.4°C, indicating that this organism is cold adapted. RG sediment-associated transcripts of soxB, which encodes a component of the S2O3 (2-)-oxidizing complex, were closely affiliated with soxB from RG5...
  48. Xiao Y, Liu X, Liang Y, Niu J, Zhang X, Ma L, et al. Insights into functional genes and taxonomical/phylogenetic diversity of microbial communities in biological heap leaching system and their correlation with functions. Appl Microbiol Biotechnol. 2016;100:9745-9756 pubmed
    ..Signal intensities of genes, including genes for sulfur oxidation (e.g., soxB), metal homeostasis (e.g., arsm), carbon fixation (e.g., rubisco), polyphosphate degradation (e.g...
  49. Di Iorgi N, Morana G, Allegri A, Napoli F, Gastaldi R, Calcagno A, et al. Classical and non-classical causes of GH deficiency in the paediatric age. Best Pract Res Clin Endocrinol Metab. 2016;30:705-736 pubmed publisher
    ..Mutations in a number of genes encoding transcription factors - such as HESX1, SOX2, SOX3, LHX3, LHX4, PROP1, POU1F1, PITX, GLI3, GLI2, OTX2, ARNT2, IGSF1, FGF8, FGFR1, PROKR2, PROK2, CHD7, WDR11, NFKB2, ..
  50. Mojsin M, Topalovic V, Vicentic J, Schwirtlich M, Stanisavljevic D, Drakulic D, et al. Crosstalk between SOXB1 proteins and WNT/β-catenin signaling in NT2/D1 cells. Histochem Cell Biol. 2015;144:429-41 pubmed publisher
    ..Our results also suggest that LiCl treatment leads to increased expression of SOX2 and SOX3 proteins in NT2/D1 cells through activation of canonical Wnt signaling...
  51. Mona B, Avila J, Meredith D, Kollipara R, Johnson J. Regulating the dorsal neural tube expression of Ptf1a through a distal 3' enhancer. Dev Biol. 2016;418:216-225 pubmed publisher
    ..Although no repressor transcription factor was identified, both PAX6 and SOX3 can increase enhancer activity in reporter assays...
  52. Sankar S, Yellajoshyula D, Zhang B, Teets B, Rockweiler N, Kroll K. Gene regulatory networks in neural cell fate acquisition from genome-wide chromatin association of Geminin and Zic1. Sci Rep. 2016;6:37412 pubmed publisher
    ..Zic1-associated peaks are enriched for Zic1 consensus binding motifs, while Zic1-bound peaks are also enriched for Sox3 motifs, suggesting co-regulatory potential...
  53. Wen J, Zeng Y, Fang Z, Gu J, Ge L, Tang F, et al. Single-cell analysis reveals lineage segregation in early post-implantation mouse embryos. J Biol Chem. 2017;292:9840-9854 pubmed publisher
    ..molecular features of the premesendoderm by expressing higher levels of mesendoderm markers and lower levels of Sox3 transcripts...
  54. Schoenmakers N, Alatzoglou K, Chatterjee V, Dattani M. Recent advances in central congenital hypothyroidism. J Endocrinol. 2015;227:R51-71 pubmed publisher
    ..the TSH biosynthetic pathway (TSHB, TRHR, IGSF1) in isolated TSH deficiency, or early (HESX1, LHX3, LHX4, SOX3, OTX2) or late (PROP1, POU1F1) pituitary transcription factors in combined hormone deficits...
  55. Richards G, Rentzsch F. Regulation of Nematostella neural progenitors by SoxB, Notch and bHLH genes. Development. 2015;142:3332-42 pubmed publisher
    Notch signalling, SoxB and Group A bHLH 'proneural' genes are conserved regulators of the neurogenic program in many bilaterians. However, the ancestry of their functions and interactions is not well understood...
  56. Kobayashi K, Khan A, Ikeda M, Nakamoto A, Maekawa M, Yamasu K. In vitro analysis of the transcriptional regulatory mechanism of zebrafish pou5f3. Exp Cell Res. 2018;364:28-41 pubmed publisher
    ..It was further shown that Luc-2.2 was activated synergistically by pou5f3 and sox3, which is similar to the co-operative activity of Oct4 and Sox2 in mice, although synergy between pou5f3 and sox2 ..
  57. Gao J, Li P, Zhang W, Wang Z, Wang X, Zhang Q. Molecular Cloning, Promoter Analysis and Expression Profiles of the sox3 Gene in Japanese Flounder, Paralichthys olivaceus. Int J Mol Sci. 2015;16:27931-44 pubmed publisher
    b>Sox3, which belongs to the SoxB1 subgroup, plays major roles in neural and gonadal development. In the present study, Japanese flounder Paralichthys olivaceus sox3 gene (Posox3) and its promoter sequence were isolated and characterized...
  58. Grabarczyk D, Chappell P, Johnson S, Stelzl L, Lea S, Berks B. Structural basis for specificity and promiscuity in a carrier protein/enzyme system from the sulfur cycle. Proc Natl Acad Sci U S A. 2015;112:E7166-75 pubmed publisher
    ..shuttles intermediates between the enzymes of the Sox pathway using the interaction between SoxYZ and the enzyme SoxB as our model...
  59. Rajakumar A, Senthilkumaran B. Sox3 binds to 11β-hydroxysteroid dehydrogenase gene promoter suggesting transcriptional interaction in catfish. J Steroid Biochem Mol Biol. 2016;158:90-103 pubmed publisher
    ..cloned from catfish genomic DNA library and in silico promoter analysis revealed putative TF binding sites such as Sox3, Wt1, Pax2, Dmrt1 and Ad4BP/SF-1...
  60. Desai K, Spikings E, Zhang T. Use of methanol as cryoprotectant and its effect on sox genes and proteins in chilled zebrafish embryos. Cryobiology. 2015;71:1-11 pubmed publisher
    ..that had been chilled for 3 h in 1 M methanol and warmed and cultured up to the hatching stages found that sox2 and sox3 gene expression were increased significantly in hatched embryos that had been chilled compared to non-chilled ..
  61. Xia X, Zhang C, Li T, Wu Q, Li N, Li W, et al. A duplication upstream of SOX9 was not positively correlated with the SRY‑negative 46,XX testicular disorder of sex development: A case report and literature review. Mol Med Rep. 2015;12:5659-64 pubmed publisher
    ..The genes RSPO1, DAX1, SOX3, ROCK, DMRT1, SPRY2 and FGF9 were also assessed using sequencing analysis. Affymetrix Cytogenetics Whole Genome 2...
  62. Myosho T, Takehana Y, Hamaguchi S, Sakaizumi M. Turnover of Sex Chromosomes in Celebensis Group Medaka Fishes. G3 (Bethesda). 2015;5:2685-91 pubmed publisher
    ..matanensis. Additionally, fine mapping and association analysis in the former two species revealed that Sox3 on the Y chromosome is a prime candidate for the SD gene, and that the Y-specific 430-bp insertion might be ..
  63. Gou Y, Vemaraju S, Sweet E, Kwon H, Riley B. sox2 and sox3 Play unique roles in development of hair cells and neurons in the zebrafish inner ear. Dev Biol. 2018;435:73-83 pubmed publisher
    ..progenitors in the inner ear requires Sox2 in mammals, and in other species is thought to rely on both Sox2 and Sox3. How Sox2 and/or Sox3 promote different fates is poorly understood...
  64. Préau L, Le Blay K, Saint Paul E, Morvan Dubois G, Demeneix B. Differential thyroid hormone sensitivity of fast cycling progenitors in the neurogenic niches of tadpoles and juvenile frogs. Mol Cell Endocrinol. 2016;420:138-51 pubmed publisher
    ..To address this question, we first used Sox3 as a marker of stem cell and progenitor populations and then applied pulse-chase EdU/IdU incorporation experiments ..
  65. Chen C, Stedman A, Havis E, Anselme I, Onichtchouk D, Giudicelli F, et al. Initiation of cyp26a1 Expression in the Zebrafish Anterior Neural Plate by a Novel Cis-Acting Element. PLoS ONE. 2016;11:e0150639 pubmed publisher
    ..A consensus bipartite binding site for SoxB:Oct transcription factors overlaps with this motif...
  66. Pillay Van Wyk V, Msemburi W, Laubscher R, Dorrington R, Groenewald P, Glass T, et al. Mortality trends and differentials in South Africa from 1997 to 2012: second National Burden of Disease Study. Lancet Glob Health. 2016;4:e642-53 pubmed publisher
    ..Metrics and Evaluation Global Burden of Disease (IHME GBD) estimates for South Africa were obtained from the IHME GHDx website for comparison...
  67. Roumaud P, Haché J, Martin L. Expression profiles of Sox transcription factors within the postnatal rodent testes. Mol Cell Biochem. 2018;447:175-187 pubmed publisher
    ..Spermatogonia were characterized by the expressions of Sox3, Sox4, Sox12, Sox13, and Sox18...
  68. Thuret R, Auger H, Papalopulu N. Analysis of neural progenitors from embryogenesis to juvenile adult in Xenopus laevis reveals biphasic neurogenesis and continuous lengthening of the cell cycle. Biol Open. 2015;4:1772-81 pubmed publisher
    ..Our study revealed the persistence of Sox3-positive progenitor cells from the earliest stages of neural development through to the juvenile adult...
  69. Dateki S, Fukami M, Uematsu A, Kaji M, Iso M, Ono M, et al. Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion. J Clin Endocrinol Metab. 2010;95:4043-7 pubmed publisher
    ..CPHD were examined for mutations and gene copy number aberrations affecting POU1F1, PROP1, HESX1, LHX3, LHX4, and SOX3 by PCR-direct sequencing and multiplex ligation-dependent probe amplification...
  70. Portela Bens S, Merlo M, Rodríguez M, Cross I, Manchado M, Kosyakova N, et al. Integrated gene mapping and synteny studies give insights into the evolution of a sex proto-chromosome in Solea senegalensis. Chromosoma. 2017;126:261-277 pubmed publisher
    ..chromosome (BAC) clones that contain candidate genes involved in such processes (dmrt1, dmrt2, dmrt3, dmrt4, sox3, sox6, sox8, sox9, lh, cyp19a1a, amh, vasa, aqp3, and nanos3) were analyzed and compared with the same region in ..
  71. Yan Q, Wang F, Miao Y, Wu X, Bai M, Xi X, et al. Sex-determining region Y-box3 (SOX3) functions as an oncogene in promoting epithelial ovarian cancer by targeting Src kinase. Tumour Biol. 2016;37:12263-12271 pubmed
    ..Recently, SOX3 has been reported to play a pivotal role in tumor progression...
  72. Laumonnier F, Ronce N, Hamel B, Thomas P, Lespinasse J, Raynaud M, et al. Transcription factor SOX3 is involved in X-linked mental retardation with growth hormone deficiency. Am J Hum Genet. 2002;71:1450-5 pubmed
    ..3 and the Xq breakpoint near the SOX3 gene (SRY [sex determining region Y]-box 3) (GenBank accession number NM_005634) at Xq26.3...
  73. Mojsin M, Popovic J, Kovacevic Grujicic N, Stevanovic M. TG-interacting factor (TGIF) downregulates SOX3 gene expression in the NT2/D1 cell line. J Genet Genomics. 2012;39:19-27 pubmed publisher
    b>SOX3 is a member of the Sox gene family implicated in brain formation and cognitive function. It is considered to be one of the earliest neural markers in vertebrates, playing a role in specifying neuronal fate...
  74. Igarashi M, Mikami H, Katsumi M, Miyado M, Izumi Y, Ogata T, et al. SOX3 Overdosage Permits Normal Sex Development in Females with Random X Inactivation. Sex Dev. 2015;9:125-9 pubmed publisher
    Submicroscopic duplications involving SOX3 and/or its flanking regions have been identified in 46,XX individuals both with and without disorders of sex development, raising the question whether SOX3 overdosage is sufficient to induce ..
  75. Jourdy Y, Chatron N, Carage M, Fretigny M, Meunier S, Zawadzki C, et al. Study of six patients with complete F9 deletion characterized by cytogenetic microarray: role of the SOX3 gene in intellectual disability. J Thromb Haemost. 2016;14:1988-1993 pubmed publisher
    ..We delineate six F9 complete deletions and investigate genotype/phenotype correlation. We identify SOX3 as a candidate gene for ID, acting through haploinsufficiency, in HB patients...
  76. Dattani M. Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene. J Pediatr Endocrinol Metab. 2003;16:1207-9 pubmed
  77. Savare J, Bonneaud N, Girard F. SUMO represses transcriptional activity of the Drosophila SoxNeuro and human Sox3 central nervous system-specific transcription factors. Mol Biol Cell. 2005;16:2660-9 pubmed
    ..Finally, we present evidence that SUMO modification of group B1 Sox factors was conserved during evolution, because Sox3, the human counterpart of SoxN, is also negatively regulated through SUMO modification.
  78. Cimadamore F, Amador Arjona A, Chen C, Huang C, Terskikh A. SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors. Proc Natl Acad Sci U S A. 2013;110:E3017-26 pubmed publisher
    ..In conclusion, we discovered the SOX2-LIN28/let-7 pathway as a unique molecular mechanism governing NPC proliferation and neurogenic potential. ..
  79. Kovacevic Grujicic N, Mojsin M, Popovic J, Petrovic I, Topalovic V, Stevanovic M. Cyclic AMP response element binding (CREB) protein acts as a positive regulator of SOX3 gene expression in NT2/D1 cells. BMB Rep. 2014;47:197-202 pubmed
    b>SOX3 is one of the earliest neural markers in vertebrates, playing the role in specifying neuronal fate...
  80. Vetro A, Dehghani M, Kraoua L, Giorda R, Beri S, Cardarelli L, et al. Testis development in the absence of SRY: chromosomal rearrangements at SOX9 and SOX3. Eur J Hum Genet. 2015;23:1025-32 pubmed publisher
    ..1, involving SOX3. CNVs involving SOX3 or its flanking regions have been reported in four XX DSD subjects...
  81. Sen D, Kaminski J, Barnitz R, Kurachi M, Gerdemann U, Yates K, et al. The epigenetic landscape of T cell exhaustion. Science. 2016;354:1165-1169 pubmed
    ..PD-1 expression is regulated in part by an exhaustion-specific enhancer that contains essential RAR, T-bet, and Sox3 motifs...
  82. Weiss J, Meeks J, Hurley L, Raverot G, Frassetto A, Jameson J. Sox3 is required for gonadal function, but not sex determination, in males and females. Mol Cell Biol. 2003;23:8084-91 pubmed
    b>Sox3 is expressed in developing gonads and in the brain...
  83. Zhu H, Shang D, Sun M, Choi S, Liu Q, Hao J, et al. X-linked congenital hypertrichosis syndrome is associated with interchromosomal insertions mediated by a human-specific palindrome near SOX3. Am J Hum Genet. 2011;88:819-826 pubmed publisher
    ..within and the other very close to a human-specific short palindromic sequence located 82 kb downstream of SOX3. In the Mexican family, we found an interchromosomal insertion at the same Xq27...
  84. Leyva Leyva M, Barrera L, López Camarillo C, Arriaga Pizano L, Orozco Hoyuela G, Carrillo Casas E, et al. Characterization of mesenchymal stem cell subpopulations from human amniotic membrane with dissimilar osteoblastic potential. Stem Cells Dev. 2013;22:1275-87 pubmed publisher
    ..Our results showed positive expression of SOX2, SOX3, PAX6, OCT3/4, and NANOG in the CD105+ and CD105(-) cell subpopulations...
  85. Takagi M, Ishii T, Torii C, Kosaki K, Hasegawa T. A novel mutation in SOX3 polyalanine tract: a case of Kabuki syndrome with combined pituitary hormone deficiency harboring double mutations in MLL2 and SOX3. Pituitary. 2014;17:569-74 pubmed publisher
    Both duplications encompassing SOX3 and loss-of function mutations in SOX3 have been reported in a minor portion of X-linked isolated growth hormone deficiency (GHD) or combined pituitary hormone deficiency (CPHD) patients with or without ..
  86. Jeng S, Wu G, Yueh W, Kuo S, Dufour S, Chang C. Gonadal development and expression of sex-specific genes during sex differentiation in the Japanese eel. Gen Comp Endocrinol. 2018;257:74-85 pubmed publisher
    ..The vasa, figla and sox3 transcripts in gonads were significantly increased during sex differentiation...
  87. Topalovic V, Krstic A, Schwirtlich M, Dolfini D, Mantovani R, Stevanovic M, et al. Epigenetic regulation of human SOX3 gene expression during early phases of neural differentiation of NT2/D1 cells. PLoS ONE. 2017;12:e0184099 pubmed publisher
    b>Sox3/SOX3 is one of the earliest neural markers in vertebrates. Together with the Sox1/SOX1 and Sox2/SOX2 genes it is implicated in the regulation of stem cell identity...
  88. Jelsig A, Diness B, Kreiborg S, Main K, Larsen V, Hove H. A complex phenotype in a family with a pathogenic SOX3 missense variant. Eur J Med Genet. 2018;61:168-172 pubmed publisher
    Duplications and deletions of Xq26-27 including SOX3 (Xq27.1) have been associated with X-linked mental retardation and isolated growth hormone deficiency (OMIM 300123) or X-linked panhypopituitarism (OMIM 312000)...
  89. Lagerstrom Fermer M, Sundvall M, Johnsen E, Warne G, Forrest S, Zajac J, et al. X-linked recessive panhypopituitarism associated with a regional duplication in Xq25-q26. Am J Hum Genet. 1997;60:910-6 pubmed
    ..The gene causing this disorder appears to code for a dosage-sensitive protein central to development of the pituitary. ..
  90. Schepers G, Teasdale R, Koopman P. Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. Dev Cell. 2002;3:167-70 pubmed
  91. Helszer Z, Dmochowska A, Szemraj J, Słowikowska Hilczer J, Wieczorek M, Jedrzejczyk S, et al. A novel mutation (c. 341A>G) in the SRY gene in a 46,XY female patient with gonadal dysgenesis. Gene. 2013;526:467-70 pubmed publisher
    ..Because of an increased risk of gonadoblastoma, proper early diagnosis and treatment prevent development of malignancies. ..
  92. Alatzoglou K, Azriyanti A, Rogers N, Ryan F, Curry N, Noakes C, et al. SOX3 deletion in mouse and human is associated with persistence of the craniopharyngeal canal. J Clin Endocrinol Metab. 2014;99:E2702-8 pubmed publisher
    b>SOX3 is an early developmental transcription factor involved in pituitary development...