SOX2-OT

Summary

Gene Symbol: SOX2-OT
Description: SOX2 overlapping transcript (non-protein coding)
Alias: NCRNA00043, SOX2OT
Species: human

Top Publications

  1. Amaral P, Neyt C, Wilkins S, Askarian Amiri M, Sunkin S, Perkins A, et al. Complex architecture and regulated expression of the Sox2ot locus during vertebrate development. RNA. 2009;15:2013-27 pubmed publisher
    ..of pluripotency embedded within an intron of a long noncoding RNA (ncRNA), termed Sox2 overlapping transcript (Sox2ot), which is transcribed in the same orientation. However, this ncRNA remains uncharacterized...
  2. Shahryari A, Rafiee M, Fouani Y, Oliae N, Samaei N, Shafiee M, et al. Two novel splice variants of SOX2OT, SOX2OT-S1, and SOX2OT-S2 are coupregulated with SOX2 and OCT4 in esophageal squamous cell carcinoma. Stem Cells. 2014;32:126-34 pubmed publisher
    ..regulator of pluripotency, is embedded within the third intron of a lncRNA known as SOX2 overlapping transcript (SOX2OT)...
  3. Fantes J, Ragge N, Lynch S, McGill N, Collin J, Howard Peebles P, et al. Mutations in SOX2 cause anophthalmia. Nat Genet. 2003;33:461-3 pubmed
    ..2) associated with bilateral anophthalmia. Subsequent SOX2 mutation analysis identified de novo truncating mutations of SOX2 in 4 of 35 (11%) individuals with anophthalmia. Both eyes were affected in all cases with an identified mutation...
  4. Shafiee M, Aleyasin S, Mowla S, Vasei M, Yazdanparast S. The Effect of MicroRNA-375 Overexpression, an Inhibitor of Helicobacter pylori-Induced Carcinogenesis, on lncRNA SOX2OT. Jundishapur J Microbiol. 2016;9:e23464 pubmed
    ..pylori-induced carcinogenesis on the expression of lncRNA SOX2 overlapping transcript (SOX2OT) and SOX2, a master regulator of pluripotency of cancer stem cells...
  5. Li Z, Li J, Ji D, Leng K, Xu Y, Huang L, et al. Overexpressed long noncoding RNA Sox2ot predicts poor prognosis for cholangiocarcinoma and promotes cell proliferation and invasion. Gene. 2018;645:131-136 pubmed publisher
    SOX2 overlapping transcript (Sox2ot), a long noncoding RNA (lncRNA), was initially found a close concomitant expression pattern of SOX2 gene...
  6. Zhang J, Zhu Y, Zhang X, Liu D, Wang Y, Yang C, et al. Yin Yang-1 suppresses pancreatic ductal adenocarcinoma cell proliferation and tumor growth by regulating SOX2OT-SOX2 axis. Cancer Lett. 2017;408:144-154 pubmed publisher
    ..that overexpression of YY1 suppressed proliferation and decreased the expression of long non-coding RNA (lncRNA) SOX2OT and its potential target gene SOX2 in PDAC cells...
  7. Tosetti V, Sassone J, Ferri A, Taiana M, Bedini G, Nava S, et al. Transcriptional role of androgen receptor in the expression of long non-coding RNA Sox2OT in neurogenesis. PLoS ONE. 2017;12:e0180579 pubmed publisher
    ..Long non-coding RNA (lncRNA) Sox2 overlapping transcript (Sox2OT) plays a crucial role in gene expression control during development but its transcriptional regulation is still to ..
  8. Zhang Y, Yang R, Lian J, Xu H. LncRNA Sox2ot overexpression serves as a poor prognostic biomarker in gastric cancer. Am J Transl Res. 2016;8:5035-5043 pubmed
    Sox2 overlapping transcript (Sox2ot) serves as an unfavorable prognostic factor in lung cancer and hepatocellular carcinoma, but the clinical significance and biological function of Sox2ot in gastric cancer is still unknown...
  9. Liu S, Xu B, Yan D. Enhanced expression of long non-coding RNA Sox2ot promoted cell proliferation and motility in colorectal cancer. Minerva Med. 2016;107:279-86 pubmed
    ..Hence, it is an urgency to find out the detailed mechanisms of how CRC occurs. LncRNA Sox2ot expression was explored in CRC tissues and cell lines by using quantitative real-time PCR (qRT-PCR)...

More Information

Publications23

  1. Li C, Wang S, Wang W, Song S, Liu X. Long Noncoding RNA-Sox2OT Knockdown Alleviates Diabetes Mellitus-Induced Retinal Ganglion Cell (RGC) injury. Cell Mol Neurobiol. 2017;37:361-369 pubmed publisher
    ..Long noncoding RNAs (lncRNAs) have emerged as the key regulators of many cell functions. Here, we show that Sox2OT expression is significantly down-regulated in the retinas of STZ-induced diabetic mice and in the RGCs upon high ..
  2. Liu X, Kelsoe J, Greenwood T. A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region. J Affect Disord. 2016;189:141-9 pubmed publisher
  3. Askarian Amiri M, Seyfoddin V, Smart C, Wang J, Kim J, Hansji H, et al. Emerging role of long non-coding RNA SOX2OT in SOX2 regulation in breast cancer. PLoS ONE. 2014;9:e102140 pubmed publisher
    ..but the SOX2 gene lies in an intron of a long multi-exon non-coding RNA called SOX2 overlapping transcript (SOX2OT)...
  4. Hou Z, Zhao W, Zhou J, Shen L, Zhan P, Xu C, et al. A long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival. Int J Biochem Cell Biol. 2014;53:380-8 pubmed publisher
    Sox2 overlapping transcript (Sox2ot) is a long noncoding RNA (lncRNA), localized on human chromosome 3q26.33, which is frequently amplified in lung squamous cell carcinomas (SCCs)...
  5. Saghaeian Jazi M, Samaei N, Ghanei M, Shadmehr M, Mowla S. Overexpression of the non-coding SOX2OT variants 4 and 7 in lung tumors suggests an oncogenic role in lung cancer. Tumour Biol. 2016;37:10329-38 pubmed publisher
    ..SOX2 overlapping transcript (SOX2OT) is a cancer-associated lncRNA gene that encodes different alternatively spliced transcripts...
  6. Saghaeian Jazi M, Samaei N, Ghanei M, Shadmehr M, Mowla S. Identification of new SOX2OT transcript variants highly expressed in human cancer cell lines and down regulated in stem cell differentiation. Mol Biol Rep. 2016;43:65-72 pubmed publisher
    ..Human SOX2 overlapping transcript (SOX2OT) gene can generate six lncRNA transcript variants which are functionally assumed to be correlated with cellular ..
  7. Shahryari A, Jazi M, Samaei N, Mowla S. Long non-coding RNA SOX2OT: expression signature, splicing patterns, and emerging roles in pluripotency and tumorigenesis. Front Genet. 2015;6:196 pubmed publisher
    SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA which harbors one of the major regulators of pluripotency, SOX2 gene, in its intronic region. SOX2OT gene is mapped to human chromosome 3q26.3 (Chr3q26...
  8. Zou J, Li C, Bao J, Zheng G. High expression of long noncoding RNA Sox2ot is associated with the aggressive progression and poor outcome of gastric cancer. Eur Rev Med Pharmacol Sci. 2016;20:4482-4486 pubmed
    The aim of our study was to investigate the expression of long non-coding RNA Sox2ot (Sox2ot) in gastric cancer (GC) patients and its association with clinicopathologic parameters and the prognosis...
  9. Shi X, Teng F. Up-regulation of long non-coding RNA Sox2ot promotes hepatocellular carcinoma cell metastasis and correlates with poor prognosis. Int J Clin Exp Pathol. 2015;8:4008-14 pubmed
    Long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in cancer biology, and the lncRNA Sox2ot is up-regulated in some tumors...
  10. Tang X, Gao Y, Yu L, Lu Y, Zhou G, Cheng L, et al. Correlations between lncRNA-SOX2OT polymorphism and susceptibility to breast cancer in a Chinese population. Biomark Med. 2017;11:277-284 pubmed publisher
    We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study...
  11. Jing X, Lin J, Wang H, Tian L, Tian R, Zhang Y, et al. Prognostic value of lncRNA SOX2OT for Chinese cancer patients: A meta-analysis. PLoS ONE. 2017;12:e0176889 pubmed publisher
    b>SOX2OT has been demonstrated to be aberrantly expressed in several types of cancer and maybe serve as a prognostic marker for cancer patients...
  12. Wang Z, Tan M, Chen G, Li Z, Lu X. LncRNA SOX2-OT is a novel prognostic biomarker for osteosarcoma patients and regulates osteosarcoma cells proliferation and motility through modulating SOX2. IUBMB Life. 2017;69:867-876 pubmed publisher
    ..2017 IUBMB Life, 69(11):867-876, 2017. ..
  13. Su R, Cao S, Ma J, Liu Y, Liu X, Zheng J, et al. Knockdown of SOX2OT inhibits the malignant biological behaviors of glioblastoma stem cells via up-regulating the expression of miR-194-5p and miR-122. Mol Cancer. 2017;16:171 pubmed publisher
    ..Here, we elucidated the function and possible molecular mechanisms of the effect of lncRNA-SOX2OT on the biological behaviors of GSCs...
  14. Boraska V, Franklin C, Floyd J, Thornton L, Huckins L, Southam L, et al. A genome-wide association study of anorexia nervosa. Mol Psychiatry. 2014;19:1085-94 pubmed publisher
    ..Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5...