SOX17

Summary

Gene Symbol: SOX17
Description: SRY-box 17
Alias: VUR3, transcription factor SOX-17, SRY (sex determining region Y)-box 17, SRY-related HMG-box transcription factor SOX17
Species: human
Products:     SOX17

Top Publications

  1. Sinner D, Rankin S, Lee M, Zorn A. Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. Development. 2004;131:3069-80 pubmed
    ..The HMG box transcription factor Sox17 is a key component of this pathway and is essential for endoderm formation; however, the molecular events ..
  2. Sinner D, Kordich J, Spence J, Opoka R, Rankin S, Lin S, et al. Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol Cell Biol. 2007;27:7802-15 pubmed
    ..We found that some Sox proteins antagonize while others enhance beta-catenin/T-cell factor (TCF) activity. Sox17, which is expressed in the normal gut epithelium but exhibits reduced expression in intestinal neoplasia, is ..
  3. Patterson E, Addis R, Shamblott M, Gearhart J. SOX17 directly activates Zfp202 transcription during in vitro endoderm differentiation. Physiol Genomics. 2008;34:277-84 pubmed publisher
    b>SOX17 is a SRY-related high-mobility group (HMG) box transcription factor that is necessary for endoderm formation in multiple species...
  4. Séguin C, Draper J, Nagy A, Rossant J. Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells. Cell Stem Cell. 2008;3:182-95 pubmed publisher
    ..that stable endoderm progenitors can be established from human ES cells by constitutive expression of SOX7 or SOX17, producing extraembryonic endoderm and definitive endoderm progenitors, respectively...
  5. Bilguvar K, Yasuno K, Niemela M, Ruigrok Y, von und zu Fraunberg M, van Duijn C, et al. Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nat Genet. 2008;40:1472-7 pubmed publisher
    ..Associated SNPs on 8q likely act via SOX17, which is required for formation and maintenance of endothelial cells, suggesting a role in development and repair ..
  6. Nakajima Takagi Y, Osawa M, Oshima M, Takagi H, Miyagi S, Endoh M, et al. Role of SOX17 in hematopoietic development from human embryonic stem cells. Blood. 2013;121:447-58 pubmed publisher
    ..Among the genes tested, only Sox17, a gene encoding a transcription factor of the SOX family, promoted cell growth and supported expansion of CD34(+)..
  7. Koka P. Biomarker discovery and biotherapeutics applications of photosynthetic light-harvesting and bioluminescence light-emitting chromophore-protein complexes in stem cell biology and regenerative medicine. J Stem Cells. 2014;9:127-33 pubmed publisher
    ..cellular MHC/TCR/CD45/CD33/CD56/CD19/CD41), and of types of stem cells (CD34/CD38/c-Mpl/Oct4/Neuropilin-1/SOX17)...
  8. Kim B, Yoon B, Moon J, Kim J, Jun E, Lee J, et al. Differentiation of human labia minora dermis-derived fibroblasts into insulin-producing cells. Exp Mol Med. 2012;44:26-35 pubmed publisher
    ..induce differentiation of hLMDFs into endoderm-like cells, as determined by the expression of the endoderm markers Sox17, Foxa2, and PDX1 (stage 2: mesenchymal-endoderm transition)...
  9. Grimm D, Bauer J, Wise P, Kruger M, Simonsen U, Wehland M, et al. The role of SOX family members in solid tumours and metastasis. Semin Cancer Biol. 2019;: pubmed publisher
    ..g. SOX2 is markedly up-regulated in chemotherapy resistant cells. The SoxF family (SOX7, SOX17, SOX18) plays an important role in angio- and lymphangiogenesis, with SOX18 seemingly being an attractive target ..

More Information

Publications135 found, 100 shown here

  1. Ou L, Fang L, Tang H, Qiao H, Zhang X, Wang Z. Dickkopf Wnt signaling pathway inhibitor 1 regulates the differentiation of mouse embryonic stem cells in vitro and in vivo. Mol Med Rep. 2016;13:720-30 pubmed publisher
    ..Increased expression levels of SOX17 were observed in the DKK1‑treated ESCs compared with the control group...
  2. Jafarian A, Taghikhani M, Abroun S, Pourpak Z, Allahverdi A, Soleimani M. Generation of high-yield insulin producing cells from human bone marrow mesenchymal stem cells. Mol Biol Rep. 2014;41:4783-94 pubmed publisher
    ..of hMSCs into definitive endoderm, pancreatic endoderm and pancreatic endocrine cells that expressed of sox17, foxa2, pdx1, ngn3, nkx2...
  3. Gilpin S, Ren X, Okamoto T, Guyette J, Mou H, Rajagopal J, et al. Enhanced lung epithelial specification of human induced pluripotent stem cells on decellularized lung matrix. Ann Thorac Surg. 2014;98:1721-9; discussion 1729 pubmed publisher
    ..anterior foregut endoderm as confirmed by forkhead box protein A2 (FOXA2), SRY (Sex Determining Region Y)-Box 17 (SOX17), and SOX2 expression...
  4. Stecklum M, Wulf Goldenberg A, Purfürst B, Siegert A, Keil M, Eckert K, et al. Cell differentiation mediated by co-culture of human umbilical cord blood stem cells with murine hepatic cells. In Vitro Cell Dev Biol Anim. 2015;51:183-91 pubmed publisher
    ..cells with cord blood cells led to less incisive differentiation with increased sex-determining region Y-box 17 (SOX17), Cx32 and Cx43, as well as epithelial CK8 and CK19 expressions...
  5. Ogaki S, Morooka M, Otera K, Kume S. A cost-effective system for differentiation of intestinal epithelium from human induced pluripotent stem cells. Sci Rep. 2015;5:17297 pubmed publisher
    ..G1 arrest, reduce apoptosis, and potentiate activation of downstream targets, such as SMAD2 phosphorylation and SOX17 expression. This increased differentiation into CDX2 + SOX17 + DE cells...
  6. Czysz K, Minger S, Thomas N. DMSO efficiently down regulates pluripotency genes in human embryonic stem cells during definitive endoderm derivation and increases the proficiency of hepatic differentiation. PLoS ONE. 2015;10:e0117689 pubmed publisher
    ..the differentiation process to monitor expression of pluripotency (POUF5/OCT4 & NANOG), definitive endoderm (SOX17, CXCR4 & GATA4) and hepatic (AFP & ALB) genes to generate differentiation stage-specific signatures...
  7. Chen A, Lee Y, Fong S, Wong C, Ng E, Yeung W. Hyperglycemia impedes definitive endoderm differentiation of human embryonic stem cells by modulating histone methylation patterns. Cell Tissue Res. 2017;368:563-578 pubmed publisher
    ..Hyperglycemic conditions significantly down-regulated the expression levels of DE markers SOX17, FOXA2, CXCR4 and EOMES during differentiation...
  8. Al Madhoun A, Ali H, AlKandari S, Atizado V, Akhter N, Al Mulla F, et al. Defined three-dimensional culture conditions mediate efficient induction of definitive endoderm lineage from human umbilical cord Wharton's jelly mesenchymal stem cells. Stem Cell Res Ther. 2016;7:165 pubmed
    ..In addition, biochemical and molecular analysis of bona-fide DE markers revealed a time-course induction of Sox17, CXCR4, and FoxA2. Focused PCR-based array also indicated a specific induction into the DE lineage...
  9. Gallagher J, Yamak A, Kirilenko P, Black S, Bochtler M, Lefebvre C, et al. Carboxy terminus of GATA4 transcription factor is required for its cardiogenic activity and interaction with CDK4. Mech Dev. 2014;134:31-41 pubmed publisher
    ..we show that the rat GATA4 likely induces cardiogenesis cell autonomously or directly as it does not require activity of endodermal transcription factor Sox17, a GATA4 target gene that induces cardiogenesis non-cell autonomously.
  10. Morrison G, Scognamiglio R, Trumpp A, Smith A. Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification. EMBO J. 2016;35:356-68 pubmed publisher
    ..GSK3 inhibition is further required for consolidation of endodermal fate via upregulation of Sox17, highlighting sequential roles for Wnt signalling...
  11. Sato K, Chitose S, Kurita T, Umeno H. Cell origin in the macula flava of the human newborn vocal fold. J Laryngol Otol. 2016;130:650-5 pubmed publisher
    ..cluster of differentiation 34, cluster of differentiation 45, collagen type I, telomerase reverse transcriptase, SOX17 and stage-specific embryonic antigen 3 was investigated...
  12. Kim S, Bozeman R, Kaisani A, Kim W, Zhang L, Richardson J, et al. Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses. Oncogene. 2016;35:3365-75 pubmed publisher
    ..After proton irradiation, a subset of SIR genes (Troy, Sox17, Opg, Faim2, Lpo, Tlr2 and Ptges) and a gene known to be involved in invasiveness (Plat), along with the ..
  13. Siltanen C, Yaghoobi M, Haque A, You J, Lowen J, Soleimani M, et al. Microfluidic fabrication of bioactive microgels for rapid formation and enhanced differentiation of stem cell spheroids. Acta Biomater. 2016;34:125-132 pubmed publisher
    ..into heparin microgels with a single dose of Nodal and FGF-2, and expressed high levels of endoderm markers Sox17 and FoxA2 after 5 days...
  14. Montanucci P, Basta G, Pescara T, Pennoni I, Di Giovanni F, Calafiore R. New simple and rapid method for purification of mesenchymal stem cells from the human umbilical cord Wharton jelly. Tissue Eng Part A. 2011;17:2651-61 pubmed publisher
    ..cells, as well as other genes that specifically relate to different embryonic germ layers, namely, Vimentin, Sox7, Sox17, FoxA2, E-cadherin, and N-cadherin...
  15. Chatagnon A, Veber P, Morin V, Bedo J, Triqueneaux G, Semon M, et al. RAR/RXR binding dynamics distinguish pluripotency from differentiation associated cis-regulatory elements. Nucleic Acids Res. 2015;43:4833-54 pubmed publisher
    ..By contrast, in differentiated cells, RAR/RXR bound regions are enriched in functional Sox17 binding sites and are characterized with a higher frequency of the canonical DR5 motif...
  16. Cho L, Wamaitha S, Tsai I, Artus J, Sherwood R, Pedersen R, et al. Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states. Development. 2012;139:2866-77 pubmed publisher
    ..pluripotency transcription factor Nanog and the expression of primitive endoderm-associated genes Gata6, Gata4, Sox17 and Pdgfra are necessary for cXEN cell derivation...
  17. Chikada H, Ito K, Yanagida A, Nakauchi H, Kamiya A. The basic helix-loop-helix transcription factor, Mist1, induces maturation of mouse fetal hepatoblasts. Sci Rep. 2015;5:14989 pubmed publisher
    ..In contrast, Mist1 suppressed expression of cholangiocytic markers such as Sox9, Sox17, Ck19, and Grhl2. CYP3A metabolic activity was significantly induced by Mist1 in this hepatoblast culture...
  18. Zavridou M, Mastoraki S, Strati A, Tzanikou E, Chimonidou M, Lianidou E. Evaluation of Preanalytical Conditions and Implementation of Quality Control Steps for Reliable Gene Expression and DNA Methylation Analyses in Liquid Biopsies. Clin Chem. 2018;64:1522-1533 pubmed publisher
    ..SB-converted DNA samples were analyzed by real-time methylation-specific PCR (MSP) for ACTB, SOX17, and BRMS1. Quality control was assessed using Levey-Jennings graphs...
  19. Farzaneh Z, Najarasl M, Abbasalizadeh S, Vosough M, Baharvand H. Developing a Cost-Effective and Scalable Production of Human Hepatic Competent Endoderm from Size-Controlled Pluripotent Stem Cell Aggregates. Stem Cells Dev. 2018;: pubmed publisher
    ..This finding confirmed by the presence of ?70% SOX17/FOXA2-double positive cells that highly expressed the anterior endodermal marker HEX...
  20. Suvorova I, Grigorash B, Chuykin I, Pospelova T, Pospelov V. G1 checkpoint is compromised in mouse ESCs due to functional uncoupling of p53-p21Waf1 signaling. Cell Cycle. 2016;15:52-63 pubmed publisher
    ..cells, down-regulation of Oct4 and Nanog pluripotent gene transcription and activation of endoderm-specific genes sox17 and afp...
  21. Davenport C, Diekmann U, Naujok O. A Quick and Efficient Method for the Purification of Endoderm Cells Generated from Human Embryonic Stem Cells. J Vis Exp. 2016;: pubmed publisher
    ..that are committed towards the endoderm lineage highly express a multitude of transcription factors such as FOXA2, SOX17, HNF1B, members of the GATA family, and the surface receptor CXCR4...
  22. Balaji S, Zhou Y, Opara E, Soker S. Combinations of Activin A or Nicotinamide with the Pancreatic Transcription Factor PDX1 Support Differentiation of Human Amnion Epithelial Cells Toward a Pancreatic Lineage. Cell Reprogram. 2017;19:255-262 pubmed publisher
    ..1 and NEUROD1. Pancreatic lineage cells expressing PDX1, SOX17, and RFX6 are derived from Pdx1-transduced hAECs treated with activin A or nicotinamide, but not cells treated ..
  23. Li W, Wang S, Qiu C, Liu Z, Zhou Q, Kong D, et al. Comprehensive bioinformatics analysis of acquired progesterone resistance in endometrial cancer cell line. J Transl Med. 2019;17:58 pubmed publisher
    ..PGR coexpression analysis revealed 7 PGR coexpressed genes (ANO1, SOX17, CGNL1, DACH1, RUNDC3B, SH3YL1 and CRISPLD1) that were also dramatically changed in IshikawaPR cells...
  24. Frost J, Estivill X, Ramsay M, Tikly M. Dysregulation of the Wnt signaling pathway in South African patients with diffuse systemic sclerosis. Clin Rheumatol. 2019;38:933-938 pubmed publisher
    ..These two groups showed paradoxical gene expression of the genes TCF7, SOX17, and FRZB in affected and unaffected skin...
  25. Liu D, Peng H, Sun Q, Zhao Z, Yu X, Ge S, et al. The Indirect Efficacy Comparison of DNA Methylation in Sputum for Early Screening and Auxiliary Detection of Lung Cancer: A Meta-Analysis. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..41-0.50) and specificity of 0.83 (0.80-0.86). Combined indirect comparisons identified the superior gene of SOX17 (sensitivity: 0.84, specificity: 0.88), CDO1 (sensitivity: 0.78, specificity: 0...
  26. Ye L, Sun L, Wu M, Wang J, Ding X, Shi H, et al. A Simple System for Differentiation of Functional Intestinal Stem Cell-like Cells from Bone Marrow Mesenchymal Stem Cells. Mol Ther Nucleic Acids. 2018;13:110-120 pubmed publisher
    ..We developed a two-step protocol in which mesenchymal stem cells (MSCs) were first induced into Sox17- or Foxa2-positive definitive endoderm cells by activin A treatment and then into Lgr5-positive ISC-like cells by ..
  27. Chieffi P. New prognostic markers and potential therapeutic targets in human testicular germ cell tumors. Curr Med Chem. 2011;18:5033-40 pubmed
    ..In the last years novel markers, including OCT3/4, SOX2, SOX17, HMGA1, HMGA2, PATZ1, GPR30, Aurora B, and others has given further advantages to discriminate between ..
  28. Heidari Keshel S, Rezaei Tavirani M, Ai J, Soleimani M, Baradaran Rafii A, Ebrahimi M, et al. Tissue-specific somatic stem-cell isolation and characterization from human endometriosis. Key roles in the initiation of endometrial proliferative disorders. Minerva Med. 2015;106:95-108 pubmed
    ..normal karyotype, adipogenic and osteogenic potential, significantly expression of Oct4, SALL4, DPPA2, Sox2, Sox17 and also specific surface markers such as CD44, CD105, CD90, CD73 and CD146 in EESCs and ELSCs was observed...
  29. Diekmann U, Davenport C, Kresse J, Naujok O. Purification of Definitive Endoderm Generated from Pluripotent Stem Cells by Magnetic Cell Sorting. Curr Protoc Stem Cell Biol. 2017;40:1D.9.1-1D.9.17 pubmed publisher
    ..Upon commitment into this lineage, the cells express transcription factors such as FOXA2, SOX17, HNF1B; GATA family members; and the surface protein CXCR4...
  30. Francis N, Moore M, Asan S, Rutter G, Burns C. Changes in microRNA expression during differentiation of embryonic and induced pluripotent stem cells to definitive endoderm. Gene Expr Patterns. 2015;19:70-82 pubmed publisher
    ..by qRT-PCR, and the relationship between one of these miRNAs, miR-151a-5p, and its predicted target gene, SOX17, was investigated by luciferase assay, and suggested an interaction between miR-151a-5p and this key transcription ..
  31. Mazmanian G, Kovshilovsky M, Yen D, Mohanty A, Mohanty S, Nee A, et al. The zebrafish dyrk1b gene is important for endoderm formation. Genesis. 2010;48:20-30 pubmed publisher
    ..The endodermal markers cas and sox17 were also moderately reduced in dyrk1b-MO animals...
  32. Kjartansdóttir K, Reda A, Panula S, Day K, Hultenby K, Söder O, et al. A Combination of Culture Conditions and Gene Expression Analysis Can Be Used to Investigate and Predict hES Cell Differentiation Potential towards Male Gonadal Cells. PLoS ONE. 2015;10:e0144029 pubmed publisher
    ..with important factors directing the fate of the male primordial germ cells in vivo to form gonocytes, such as SOX17 or genes involved in the NODAL/ACTIVIN pathway, for example...
  33. Chng S, Ho L, Tian J, Reversade B. ELABELA: a hormone essential for heart development signals via the apelin receptor. Dev Cell. 2013;27:672-80 pubmed publisher
    ..ela null embryos have impaired endoderm differentiation potential marked by reduced gata5 and sox17 expression...
  34. Abulaiti X, Zhang H, Wang A, Li N, Li Y, Wang C, et al. Phosphorylation of Threonine343 Is Crucial for OCT4 Interaction with SOX2 in the Maintenance of Mouse Embryonic Stem Cell Pluripotency. Stem Cell Reports. 2017;9:1630-1641 pubmed publisher
    ..Loss of such OCT4-phosphorylation compromises its interaction with SOX2 but promotes interaction with SOX17. We therefore propose that threonine343-based OCT4-phosphorylation is crucial for the maintenance of ..
  35. Yao L, Shen H, Laird P, Farnham P, Berman B. Inferring regulatory element landscapes and transcription factor networks from cancer methylomes. Genome Biol. 2015;16:105 pubmed publisher
    ..We identified networks regulated by known cancer drivers such as GATA3 and FOXA1 (breast cancer), SOX17 and FOXA2 (endometrial cancer), and NFE2L2, SOX2, and TP63 (squamous cell lung cancer)...
  36. Matz P, Wruck W, Fauler B, Herebian D, Mielke T, Adjaye J. Footprint-free human fetal foreskin derived iPSCs: A tool for modeling hepatogenesis associated gene regulatory networks. Sci Rep. 2017;7:6294 pubmed publisher
    ..g. OCT4 expression at the undifferentiated stage, SOX17 marking the DE stage, DLK and HNF6 the HE stage, HNF4α and Albumin is specific to HLCs, fetal liver and adult ..
  37. Mahmoodinia Maymand M, Soleimanpour Lichaei H, Ardeshirylajimi A, Soleimani M, Enderami S, Nojehdehi S, et al. Improvement of hepatogenic differentiation of iPS cells on an aligned polyethersulfone compared to random nanofibers. Artif Cells Nanomed Biotechnol. 2018;46:853-860 pubmed publisher
    ..difference in the mRNA and protein levels of two important definitive endoderm specific markers, including Sox17 and Foxa2 between two scaffolds...
  38. Balaji S, Zhou Y, Ganguly A, Opara E, Soker S. The combined effect of PDX1, epidermal growth factor and poly-L-ornithine on human amnion epithelial cells' differentiation. BMC Dev Biol. 2016;16:8 pubmed publisher
    ..Other markers of various stages of pancreatic differentiation such as NKX6.1, SOX17, RFX6, FOXA2, CFTR, NEUROD1, PAX4 and PPY were also expressed upon Pdx1 transduction...
  39. Asumda F, Hatzistergos K, Dykxhoorn D, Jakubski S, Edwards J, Thomas E, et al. Differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules. Differentiation. 2018;101:16-24 pubmed publisher
    ..Quantitative gene-expression, immunohistochemical, and western blot analyses for SOX17, FOXA2, CXCR4, HNF4A, AFP, indicated the stage-specific differentiation into definitive endoderm, hepatoblast and ..
  40. Majchrzak Celińska A, Słocińska M, Barciszewska A, Nowak S, Baer Dubowska W. Wnt pathway antagonists, SFRP1, SFRP2, SOX17, and PPP2R2B, are methylated in gliomas and SFRP1 methylation predicts shorter survival. J Appl Genet. 2016;57:189-97 pubmed publisher
    ..The methylation of SFRP1, SFRP2, PPP2R2B, DKK1, SOX17, and DACH1 was analyzed in 64 glioma samples using methylation-specific polymerase chain reaction (MSP)...
  41. Ng E, Azzola L, Bruveris F, Calvanese V, Phipson B, Vlahos K, et al. Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros. Nat Biotechnol. 2016;34:1168-1179 pubmed publisher
    ..Using reporter hESC lines to track the endothelial (SOX17) to hematopoietic (RUNX1C) transition that occurs in development, we show that simultaneous modulation of WNT and ..
  42. Gimelli S, Caridi G, Beri S, McCracken K, Bocciardi R, Zordan P, et al. Mutations in SOX17 are associated with congenital anomalies of the kidney and the urinary tract. Hum Mutat. 2010;31:1352-9 pubmed publisher
    ..We have identified mutations in SOX17, an HMG-box transcription factor and Wnt signaling antagonist, in eight patients with CAKUT (seven vesico-ureteric ..
  43. Zhu P, Xu X, Lin X. Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning. Biol Open. 2015;4:1376-86 pubmed publisher
    ..of a constitutively active form of Lef1 also induced an ectopic protrusion that contains ectopic transcripts for sox17, foxj1a, and charon, and ectopic monocilia...
  44. Huang J, Guo X, Li W, Zhang H. Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes. Sci Rep. 2017;7:40716 pubmed publisher
    ..synthase kinase 3 (GSK3) inhibitors alone, the expression of definitive endoderm specific genes GATA4, FOXA2, and SOX17 in hASCs significantly increased in a manner with activation of Wnt/β-catenin signalling...
  45. Task K, Jaramillo M, Banerjee I. Population based model of human embryonic stem cell (hESC) differentiation during endoderm induction. PLoS ONE. 2012;7:e32975 pubmed publisher
    ..cell population is analyzed daily for cellular growth, cell death, and expression of the endoderm proteins Sox17 and CXCR4...
  46. Clarke R, Robitaille A, Moon R, Keller G. A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17. Stem Cell Reports. 2015;5:291-304 pubmed publisher
    ..Additionally, we provide evidence that the generation of the Stat1(+) definitive lineage is dependent on Sox17. These findings establish an approach for monitoring the emergence of definitive hematopoiesis in the PSC ..
  47. Cuvertino S, Lacaud G, Kouskoff V. SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development. Open Biol. 2016;6: pubmed publisher
    During embryogenesis, the three SOXF transcription factors, SOX7, SOX17 and SOX18, regulate the specification of the cardiovascular system and are also involved in the development of haematopoiesis...
  48. Masaki H, Kato Itoh M, Takahashi Y, Umino A, Sato H, Ito K, et al. Inhibition of Apoptosis Overcomes Stage-Related Compatibility Barriers to Chimera Formation in Mouse Embryos. Cell Stem Cell. 2016;19:587-592 pubmed publisher
    ..that transient promotion of cell survival through expression of the anti-apoptotic gene BCL2 enables EpiSCs and Sox17+ endoderm progenitors to integrate into blastocysts and contribute to chimeric embryos...
  49. Guo H, Hu B, Yan L, Yong J, Wu Y, Gao Y, et al. DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells. Cell Res. 2017;27:165-183 pubmed publisher
    ..are enriched specifically for binding motifs of the pluripotency and germ cell master regulators such as NANOG, SOX17, AP2? and OCT4 in human FGCs, indicating the existence of a delicate regulatory balance between pluripotency-..
  50. Saito K, Nobuhisa I, Harada K, Takahashi S, Anani M, Lickert H, et al. Maintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis. Exp Cell Res. 2018;365:145-155 pubmed publisher
    ..We previously reported expression of the transcription factor Sox17 in IAHCs, and overexpression of Sox17 in CD45lowc-KIThigh cells comprising IAHCs maintains ..
  51. Katoh M. Molecular cloning and characterization of human SOX17. Int J Mol Med. 2002;9:153-7 pubmed
    ..Xenopus Sox17 alpha, Sox17 beta, and Sox3 are reported to negatively modulate the WNT - beta-catenin - TCF signaling pathway...
  52. Lizama C, Hawkins J, Schmitt C, Bos F, Zape J, Cautivo K, et al. Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition. Nat Commun. 2015;6:7739 pubmed publisher
    ..Tissue-specific, temporally controlled, genetic loss of arterial genes (Sox17 and Notch1) during EHT results in increased production of haematopoietic cells due to loss of Sox17-mediated ..
  53. Elahi S, Homstad A, Vaidya H, Stout J, Hall G, Wu G, et al. Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux. Pediatr Nephrol. 2016;31:247-53 pubmed publisher
    ..NFPVUR) for rare missense variants inTNXB and the tenascin C gene (TNC) after excluding mutations in ROBO2 and SOX17. The screening procedure identified 134 individuals from 112 families with PVUR; two families with mutations in ..
  54. Van Oudenhove J, Grandy R, Ghule P, del Rio R, Lian J, Stein J, et al. Lineage-Specific Early Differentiation of Human Embryonic Stem Cells Requires a G2 Cell Cycle Pause. Stem Cells. 2016;34:1765-75 pubmed publisher
    ..during meso- and endodermal differentiation selectively decreased expression of definitive endodermal markers SOX17 and FOXA2...
  55. Li Z, Heng J, Yan J, Guo X, Tang L, Chen M, et al. Integrated analysis of gene expression and methylation profiles of 48 candidate genes in breast cancer patients. Breast Cancer Res Treat. 2016;160:371-383 pubmed
    ..A total of 9 genes (CCND2, EGFR, GSTP1, PGR, PTGS2, RECK, SOX17, TNFRSF10D, and WIF1) showed significant negative correlation between methylation and gene expression, which were ..
  56. Kim I, Kim K, Lee E, Oh D, Park C, Park S, et al. Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality. J Exp Med. 2018;215:963-983 pubmed publisher
    ..We found up-regulation of Sox7 and down-regulation of Sox17 in tumor endothelial cells (tECs) in mouse HGG...
  57. Nettersheim D, Heimsoeth A, Jostes S, Schneider S, Fellermeyer M, Hofmann A, et al. SOX2 is essential for in vivo reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate. Oncotarget. 2016;7:47095-47110 pubmed publisher
    ..to induction of NODAL signaling, upregulation of pluripotency factors and downregulation of seminoma markers, like SOX17. The pluripotency factor and EC-marker SOX2 is strongly induced...
  58. Bonney S, Harrison Uy S, Mishra S, MacPherson A, Choe Y, Li D, et al. Diverse Functions of Retinoic Acid in Brain Vascular Development. J Neurosci. 2016;36:7786-801 pubmed publisher
    ..inhibit WNT-?-catenin transcriptional activity and that this is required to moderate the expression of WNT target Sox17. From this, a model emerges in which RA acts upstream of the WNT pathway via non-cell-autonomous and cell-..
  59. Li Z, Guo X, Tang L, Peng L, Chen M, Luo X, et al. Methylation analysis of plasma cell-free DNA for breast cancer early detection using bisulfite next-generation sequencing. Tumour Biol. 2016;37:13111-13119 pubmed
    ..To evaluate the methylation levels of six candidate genes (EGFR, GREM1, PDGFRB, PPM1E, SOX17, and WRN) in plasma cfDNA as biomarkers for breast cancer early detection, quantitative analysis of the promoter ..
  60. Chang W, Lai W, Kuo I, Lin C, Lu P, Sheu B, et al. A six-CpG panel with DNA methylation biomarkers predicting treatment response of chemoradiation in esophageal squamous cell carcinoma. J Gastroenterol. 2017;52:705-714 pubmed publisher
    ..A risk score equation comprising six CpG probes located in IFNGR2, KCNK4, NOTCH4, NPY, PAX6, and SOX17 genes were built...
  61. Lin C, Tsai M, Liu Y, Lu Y, Chen Y, Lai Y, et al. Klf8 regulates left-right asymmetric patterning through modulation of Kupffer's vesicle morphogenesis and spaw expression. J Biomed Sci. 2017;24:45 pubmed publisher
    ..Dorsal forerunner cell number was evaluated in Tg(sox17:gfp) embryos and the length and number of cilia in Kupffer's vesicle were analyzed by immunocytochemistry using an ..
  62. Taha M, Javeri A, Majidizadeh T, Valojerdi M. Both BMP4 and serum have significant roles in differentiation of embryonic stem cells to primitive and definitive endoderm. Cytotechnology. 2016;68:1315-24 pubmed publisher
    ..Quantitative real-time PCR analysis showed higher expression levels of Sox17, Pdx1, Cdx2 and Villin mRNAs in the KoSR plus BMP4 condition and higher Gata4 and Afp expression levels in the FBS ..
  63. Hou L, Srivastava Y, Jauch R. Molecular basis for the genome engagement by Sox proteins. Semin Cell Dev Biol. 2017;63:2-12 pubmed publisher
    ..Here we discuss our current knowledge on how Sox transcription factors such as Sox2, Sox17, Sox18 and Sox9 'read' the genome to find and regulate their target genes and highlight the roles of partner ..
  64. Cao S, Yu S, Chen Y, Wang X, Zhou C, Liu Y, et al. Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage. J Biol Chem. 2017;292:19122-19132 pubmed publisher
    ..Subsequent cell fate mapping reveals a robust induction of SOX17 in the resulting epithelial-like cells that can be further reprogrammed to endodermal progenitor cells...
  65. Jankowska Steifer E, Niderla Bielinska J, Ciszek B, Kujawa M, Bartkowiak M, Flaht Zabost A, et al. Cells with hematopoietic potential reside within mouse proepicardium. Histochem Cell Biol. 2018;149:577-591 pubmed publisher
    ..e., Runx1, Notch1, Gata2, and Sox17. Our data are in line with previous observation on hemangioblast derivation from the quail PE.
  66. Du Y, Oshima H, Oguma K, Kitamura T, Itadani H, Fujimura T, et al. Induction and down-regulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis. Gastroenterology. 2009;137:1346-57 pubmed publisher
    The activation of Wnt/beta-catenin signaling causes the development of gastric and colon cancers. Sox17 represses Wnt/beta-catenin signaling and is down-regulated in colon cancer...
  67. Fukamachi H, Shimada S, Ito K, Ito Y, Yuasa Y. CD133 is a marker of gland-forming cells in gastric tumors and Sox17 is involved in its regulation. Cancer Sci. 2011;102:1313-21 pubmed publisher
    ..Microarray analysis showed that CD133(+) cells specifically expressed Sox17, a tumor suppressor in gastric carcinogenesis...
  68. Bos F, Hawkins J, Zovein A. Single-cell resolution of morphological changes in hemogenic endothelium. Development. 2015;142:2719-24 pubmed publisher
    ..events of EHT, and to correlate cellular morphology with the expression of the transcription factors RUNX1 and SOX17. A novel strategy was developed to allow for correlation of immunofluorescence data with the ultrastructural ..
  69. Waisbourd Zinman O, Koh H, Tsai S, Lavrut P, Dang C, Zhao X, et al. The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis through decreased glutathione and SOX17. Hepatology. 2016;64:880-93 pubmed publisher
    ..We examined the effects of biliatresone on SOX17 levels and determined the effects of Sox17 knockdown on cholangiocytes in 3D culture...
  70. Miller A, Satchie A, Tannenbaum A, Nihal A, Thomson J, Vereide D. Expandable Arterial Endothelial Precursors from Human CD34+ Cells Differ in Their Proclivity to Undergo an Endothelial-to-Mesenchymal Transition. Stem Cell Reports. 2018;10:73-86 pubmed publisher
    ..Here, we find that two transcription factors, MYCN and SOX17, induce and indefinitely expand in culture precursors of human arterial endothelial cells (expandable arterial ..
  71. Guimarães Young A, Neff T, Dupuy A, Goodheart M. Conditional deletion of Sox17 reveals complex effects on uterine adenogenesis and function. Dev Biol. 2016;414:219-27 pubmed publisher
    ..b>Sox17 is a transcription factor characterized in numerous tissues as an antagonist of Wnt signaling...
  72. Harada K, Nobuhisa I, Anani M, Saito K, Taga T. Thrombopoietin contributes to the formation and the maintenance of hematopoietic progenitor-containing cell clusters in the aorta-gonad-mesonephros region. Cytokine. 2017;95:35-42 pubmed publisher
    ..We have previously reported that forced expression of the Sox17 transcription factor in CD45lowc-Kithigh AGM cells, which are the hematopoietic cellular ..
  73. Qu S, Yan L, Fang B, Ye S, Li P, Ge S, et al. Generation of enhanced definitive endoderm from human embryonic stem cells under an albumin/insulin-free and chemically defined condition. Life Sci. 2017;175:37-46 pubmed publisher
    ..Expression of DE-associated SOX17 and FOXA2 genes was analyzed by real time reverse transcription polymerase chain reaction (RT-PCR) and Western ..
  74. Kremer P, Koeleman B, Pawlikowska L, Weinsheimer S, Bendjilali N, Sidney S, et al. Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain. J Neurol Neurosurg Psychiatry. 2015;86:524-9 pubmed publisher
    ..Possible involvement of SOX-17 and RBBP8, genes involved in cell cycle progression, deserves further investigation. ..
  75. Hong E, Kim B, Kim C, Choi H, Jeon J. Association of SOX17 Gene Polymorphisms and Intracranial Aneurysm: A Case-Control Study and Meta-Analysis. World Neurosurg. 2018;110:e823-e829 pubmed publisher
    Genome-wide association studies have revealed an association between SRY-box 17 (SOX17) gene and intracranial aneurysm (IA) formation. However, results were mainly derived from European and Japanese populations...
  76. Semb H. Expandable endodermal progenitors: new tools to explore endoderm and its derivatives. Cell Stem Cell. 2008;3:355-6 pubmed publisher
    ..2008) used a reporter gene strategy to isolate replicating anterior definitive endoderm from mESCs. ..
  77. Jia Y, Yang Y, Liu S, Herman J, Lu F, Guo M. SOX17 antagonizes WNT/?-catenin signaling pathway in hepatocellular carcinoma. Epigenetics. 2010;5:743-9 pubmed publisher
    SRY-box containing gene 17 (SOX17) was reported to be indispensable for embryonic development and a candidate tumor suppressor gene which antagonizes the canonical WNT/?-catenin signaling pathway in colorectal cancer...
  78. Balgkouranidou I, Karayiannakis A, Matthaios D, Bolanaki H, Tripsianis G, Tentes A, et al. Assessment of SOX17 DNA methylation in cell free DNA from patients with operable gastric cancer. Association with prognostic variables and survival. Clin Chem Lab Med. 2013;51:1505-10 pubmed publisher
    ..The aim of our study was to evaluate the prognostic significance of SOX17 promoter methylation status in patients with operable gastric cancer...
  79. Chen H, Chew L, Packer R, Gallo V. Modulation of the Wnt/beta-catenin pathway in human oligodendroglioma cells by Sox17 regulates proliferation and differentiation. Cancer Lett. 2013;335:361-71 pubmed publisher
    ..Unlike normal primary human OPCs, beta-catenin in HOG cells is not associated with endogenous Sox17 protein despite high levels of both proteins...
  80. Fu D, Tan H, Wei J, Zhu C, Jiang J, Zhu Y, et al. Decreased expression of SOX17 is associated with tumor progression and poor prognosis in breast cancer. Tumour Biol. 2015;36:8025-34 pubmed publisher
    The SOX17 (SRY-related HMG-box) transcription factor is involved in a variety of biological processes and is related to the tumorigenesis and progression of multiple tumors...
  81. Hata T, Dal Molin M, Hong S, Tamura K, Suenaga M, Yu J, et al. Predicting the Grade of Dysplasia of Pancreatic Cystic Neoplasms Using Cyst Fluid DNA Methylation Markers. Clin Cancer Res. 2017;23:3935-3944 pubmed publisher
    ..and 154 validation) aspirated after surgical resection were analyzed for methylated DNA at selected genes (SOX17, BNIP3, FOXE1, PTCHD2, SLIT2, EYA4, and SFRP1) using methylation-specific droplet-digital PCR (dd-QMSP)...
  82. Kojima Y, Sasaki K, Yokobayashi S, Sakai Y, Nakamura T, Yabuta Y, et al. Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells. Cell Stem Cell. 2017;21:517-532.e5 pubmed publisher
    ..of iMeLCs is dictated by the duration and dosage of WNT signaling, which induces expression of EOMES to activate SOX17, a key driver of hPGCLC specification...
  83. Wang P, Rodriguez R, Wang J, Ghodasara A, Kim S. Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm. Cell Stem Cell. 2011;8:335-46 pubmed publisher
    ..recombination in human ESCs, we inserted an enhanced green fluorescent protein (eGFP) transgene into the SOX17 locus, a postulated marker of human endoderm...
  84. Li J, Han C, Zheng L, Guo M. Epigenetic regulation of Wnt signaling pathway gene SRY-related HMG-box 17 in papillary thyroid carcinoma. Chin Med J (Engl). 2012;125:3526-31 pubmed
    SRY-related HMG-box 17 (SOX17) encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate...
  85. Irie N, Weinberger L, Tang W, Kobayashi T, Viukov S, Manor Y, et al. SOX17 is a critical specifier of human primordial germ cell fate. Cell. 2015;160:253-68 pubmed publisher
    ..Remarkably, SOX17 is the key regulator of hPGC-like fate, whereas BLIMP1 represses endodermal and other somatic genes during ..
  86. Balgkouranidou I, Chimonidou M, Milaki G, Tsaroucha E, Kakolyris S, Georgoulias V, et al. SOX17 promoter methylation in plasma circulating tumor DNA of patients with non-small cell lung cancer. Clin Chem Lab Med. 2016;54:1385-93 pubmed publisher
    b>SOX17 belongs to the high-mobility group-box transcription factor superfamily and down-regulates the Wnt pathway...
  87. Hoepfner J, Kleinsorge M, Papp O, Ackermann M, Alfken S, Rinas U, et al. Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells. Cell Biol Int. 2016;40:534-48 pubmed publisher
    ..Wnt pathway-modulated cells were determined based on the expression levels of the endodermal transcription factors SOX17 and FOXA2 and those of the transcription activator GATA4 and the ?-fetoprotein (AFP) gene, respectively...
  88. Zhou Z, Yang X, He J, Liu J, Wu F, Yu S, et al. Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function. Cell Rep. 2017;21:2160-2170 pubmed publisher
    ..ubiquitination at genes linked to development, resulting in the expression of mesendodermal factors such as Sox17 and a consequent suppression of somatic reprogramming. These observations reveal that PRC1...
  89. Hoeth M, Niederleithner H, Hofer Warbinek R, Bilban M, Mayer H, Resch U, et al. The transcription factor SOX18 regulates the expression of matrix metalloproteinase 7 and guidance molecules in human endothelial cells. PLoS ONE. 2012;7:e30982 pubmed publisher
  90. Yin D, Jia Y, Yu Y, Brock M, Herman J, Han C, et al. SOX17 methylation inhibits its antagonism of Wnt signaling pathway in lung cancer. Discov Med. 2012;14:33-40 pubmed
    The purpose of this study was to explore epigenetic changes and functions of SOX17 in human lung cancer. Five lung cancer cell lines and 88 primary lung cancer samples were examined in this study...
  91. Du L, Qian X, Dai C, Wang L, Huang D, Wang S, et al. Screening the molecular targets of ovarian cancer based on bioinformatics analysis. Tumori. 2015;101:384-9 pubmed publisher
    ..Then, PPI network was constructed, and DEGs CDKN2A, MUC1, OGN, ZIC1, SOX17, and TFAP2A interacted with known OC-related genes CDK4, EGFR/JUN, SRC, CLI1, CTNNB1, and TP53, respectively...
  92. Lilly A, Costa G, Largeot A, Fadlullah M, Lie A Ling M, Lacaud G, et al. Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac. Development. 2016;143:4341-4351 pubmed
    ..that SOX7 is broadly expressed across the RUNX1+ yolk sac HE population compared with SOX17. Collectively, these data demonstrate for the first time how direct protein-protein interactions between ..