SORT1

Summary

Gene Symbol: SORT1
Description: sortilin 1
Alias: Gp95, LDLCQ6, NT3, NTR3, sortilin, 100 kDa NT receptor, glycoprotein 95, neurotensin receptor 3
Species: human
Products:     SORT1

Top Publications

  1. Mazella J, Zsurger N, Navarro V, Chabry J, Kaghad M, Caput D, et al. The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor. J Biol Chem. 1998;273:26273-6 pubmed
    ..This cDNA encodes a 833-amino acid protein 100% identical to the recently cloned gp95/sortilin and was then designated NT3 receptor-gp95/sortilin...
  2. Hampe W, Rezgaoui M, Hermans Borgmeyer I, Schaller H. The genes for the human VPS10 domain-containing receptors are large and contain many small exons. Hum Genet. 2001;108:529-36 pubmed
    The two human proteins with a VPS10 domain, SorLA and sortilin, both bind neuropeptides. Searching for other VPS10-domain proteins in the database revealed three new putative human neuropeptide receptors...
  3. Navarro V, Vincent J, Mazella J. Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line. Biochem Biophys Res Commun. 2002;298:760-4 pubmed
    The neurotensin (NT) receptor-3/sortilin (NTR3) belongs to the new receptor family of VPS10P domain containing receptors...
  4. Fauchais A, Lalloue F, Lise M, Boumediene A, Preud homme J, Vidal E, et al. Role of endogenous brain-derived neurotrophic factor and sortilin in B cell survival. J Immunol. 2008;181:3027-38 pubmed
    ..Whereas BDNF secretion was described in B lymphocytes, the ability of B cells to produce sortilin, its transport protein, was not previously reported...
  5. FINAN G, Okada H, Kim T. BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin. J Biol Chem. 2011;286:12602-16 pubmed publisher
    ..Here we investigated whether sortilin, a Vps10p domain-sorting receptor believed to participate in retromer-mediated transport of select membrane ..
  6. Prudencio M, Jansen West K, Lee W, Gendron T, Zhang Y, Xu Y, et al. Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor. Proc Natl Acad Sci U S A. 2012;109:21510-5 pubmed publisher
    b>Sortilin 1 regulates the levels of brain progranulin (PGRN), a neurotrophic growth factor that, when deficient, is linked to cases of frontotemporal lobar degeneration with TAR DNA-binding protein-43 (TDP-43)-positive inclusions (FTLD-TDP)..
  7. Tauris J, Ellgaard L, Jacobsen C, Nielsen M, Madsen P, Thøgersen H, et al. The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin. FEBS Lett. 1998;429:27-30 pubmed
    Binding of the receptor-associated protein (RAP) to the newly identified putative sorting receptor, sortilin, was analyzed by surface plasmon resonance analysis of recombinant RAP and sortilin domains and compared with binding to megalin ..
  8. Lefrancois S, Zeng J, Hassan A, Canuel M, Morales C. The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin. EMBO J. 2003;22:6430-7 pubmed
    ..We tested the hypothesis that SAPs are targeted to the lysosomal compartment via the sortilin receptor...
  9. Teng H, Teng K, Lee R, Wright S, Tevar S, Almeida R, et al. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci. 2005;25:5455-63 pubmed
    ..form of NGF, is more active than mature NGF in inducing apoptosis after binding to p75NTR and a coreceptor, sortilin, we asked whether the precursor of BDNF (proBDNF) is also a proapoptotic ligand in the nervous system...

More Information

Publications105 found, 100 shown here

  1. McKeown P, Merlini P, Berzuini C, Bernardinelli L, Peyvandi F, Tubaro M, et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet. 2009;41:334-41 pubmed publisher
    ..6p24 in PHACTR1 and 2q33 in WDR12) and six replicated prior observations (9p21, 1p13 near CELSR2-PSRC1-SORT1, 10q11 near CXCL12, 1q41 in MIA3, 19p13 near LDLR and 1p32 near PCSK9)...
  2. Musunuru K, Strong A, Frank Kamenetsky M, Lee N, Ahfeldt T, Sachs K, et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature. 2010;466:714-9 pubmed publisher
    ..C/EBP (CCAAT/enhancer binding protein) transcription factor binding site and alters the hepatic expression of the SORT1 gene...
  3. Gustafsen C, Glerup S, Pallesen L, Olsen D, Andersen O, Nykjær A, et al. Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein. J Neurosci. 2013;33:64-71 pubmed publisher
    ..We here identify sortilin as a novel APP interaction partner...
  4. Mazella J. Sortilin/neurotensin receptor-3: a new tool to investigate neurotensin signaling and cellular trafficking?. Cell Signal. 2001;13:1-6 pubmed
    ..sum up the complexity for researchers involved in the functional significance of the so-called sortilin/neurotensin receptor 3 (NTR3)...
  5. Nielsen M, Madsen P, Christensen E, Nykjaer A, Gliemann J, Kasper D, et al. The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. EMBO J. 2001;20:2180-90 pubmed
    b>Sortilin belongs to a growing family of multiligand type-1 receptors with homology to the yeast receptor Vps10p...
  6. Morinville A, Martin S, Lavallée M, Vincent J, Beaudet A, Mazella J. Internalization and trafficking of neurotensin via NTS3 receptors in HT29 cells. Int J Biochem Cell Biol. 2004;36:2153-68 pubmed
    The neurotensin receptor-3, originally identified as sortilin, is unique among neuropeptide receptors in that it is a single trans-membrane domain, type I receptor...
  7. Chen Z, Ieraci A, Teng H, Dall H, Meng C, Herrera D, et al. Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. J Neurosci. 2005;25:6156-66 pubmed
    ..Here, we report a novel function for a Vps10p domain protein, sortilin, in controlling BDNF sorting to the regulated secretory pathway...
  8. Quistgaard E, Madsen P, Grøftehauge M, Nissen P, Petersen C, Thirup S. Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain. Nat Struct Mol Biol. 2009;16:96-8 pubmed publisher
    The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2-A resolution, revealing that the C-terminal part of neurotensin binds in the tunnel of a ten-bladed beta-propeller domain...
  9. Vaegter C, Jansen P, Fjorback A, Glerup S, Skeldal S, Kjolby M, et al. Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci. 2011;14:54-61 pubmed publisher
    ..The mechanism responsible for this trafficking remains poorly understood. Here we show that the sorting receptor sortilin interacts with TrkA, TrkB and TrkC and enables their anterograde axonal transport, thereby enhancing neurotrophin ..
  10. Kwon S, Christian J. Sortilin associates with transforming growth factor-beta family proteins to enhance lysosome-mediated degradation. J Biol Chem. 2011;286:21876-85 pubmed publisher
    ..The current studies show that sortilin selectively co-immunoprecipitates with the cleaved prodomain and/or precursor form of TGF-? family members...
  11. Petersen C, Nielsen M, Nykjaer A, Jacobsen L, Tommerup N, Rasmussen H, et al. Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J Biol Chem. 1997;272:3599-605 pubmed
    ..A approximately 95-kDa membrane glycoprotein, designated gp95/sortilin, was purified from human brain extracts by RAP affinity chromatography and cloned in a human cDNA library...
  12. Munck Petersen C, Nielsen M, Jacobsen C, Tauris J, Jacobsen L, Gliemann J, et al. Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding. EMBO J. 1999;18:595-604 pubmed
    We recently reported the isolation and sequencing of sortilin, a new putative sorting receptor that binds receptor-associated protein (RAP)...
  13. Nielsen M, Jacobsen C, Olivecrona G, Gliemann J, Petersen C. Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J Biol Chem. 1999;274:8832-6 pubmed
    ..We have investigated if lipoprotein lipase interacts with the RAP binding but structurally distinct receptor sortilin/neurotensin receptor-3...
  14. Nykjaer A, Lee R, Teng K, Jansen P, Madsen P, Nielsen M, et al. Sortilin is essential for proNGF-induced neuronal cell death. Nature. 2004;427:843-8 pubmed
    b>Sortilin (approximately 95 kDa) is a member of the recently discovered family of Vps10p-domain receptors, and is expressed in a variety of tissues, notably brain, spinal cord and muscle...
  15. Westergaard U, Sørensen E, Hermey G, Nielsen M, Nykjaer A, Kirkegaard K, et al. Functional organization of the sortilin Vps10p domain. J Biol Chem. 2004;279:50221-9 pubmed
    A Vps10p domain makes up the entire luminal part of Sortilin, and this type of domain is the hallmark of a new family of neuronal receptors that target a variety of ligands, including neurotrophins and neuropeptides...
  16. Carrasquillo M, Nicholson A, Finch N, Gibbs J, Baker M, Rutherford N, et al. Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma. Am J Hum Genet. 2010;87:890-7 pubmed publisher
    ..Overall, each copy of the minor C allele decreased GRN levels by ?15%. SNP rs646776 is located near sortilin (SORT1), and the minor C allele of rs646776 was previously associated with increased SORT1 mRNA levels...
  17. Lang U, Borgwardt S. Molecular mechanisms of depression: perspectives on new treatment strategies. Cell Physiol Biochem. 2013;31:761-77 pubmed publisher
    ..hippocampal volumes in depressed patients and changes of neurotrophic support by BDNF, erythropoietin, GDNF, FGF-2, NT3, NGF and growth hormone...
  18. Rajan T, Diomede F, Bramanti P, Trubiani O, Mazzon E. Conditioned medium from human gingival mesenchymal stem cells protects motor-neuron-like NSC-34 cells against scratch-injury-induced cell death. Int J Immunopathol Pharmacol. 2017;:394632017740976 pubmed publisher
    ..Moreover, hGMSC-CM treatment upregulated neurotrophins anti-brain-derived neurotrophic factor (BDNF) and NT3. Western blot data of hGMSC-CM revealed the presence of neurotrophins nerve growth factor (NGF), NT3, anti-..
  19. Greaves E, Temp J, Esnal Zufiurre A, Mechsner S, Horne A, Saunders P. Estradiol is a critical mediator of macrophage-nerve cross talk in peritoneal endometriosis. Am J Pathol. 2015;185:2286-97 pubmed publisher
    ..with E2 increased the number of macrophages in lesions as well as concentrations of mRNAs encoded by Csf1, Nt3, and the tyrosine kinase neurotrophin receptor, TrkB...
  20. Lo K, Vadlamudi S, Fogarty M, Mohlke K, Lettre G. Strategies to fine-map genetic associations with lipid levels by combining epigenomic annotations and liver-specific transcription profiles. Genomics. 2014;104:105-12 pubmed publisher
    ..This method recognized the known SORT1 rs12740374 regulatory SNP associated with LDL-cholesterol, and highlighted candidate functional SNPs at 15 ..
  21. Cheng H, Besla R, Li A, Chen Z, Shikatani E, Nazari Jahantigh M, et al. Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a. Circ Res. 2017;121:354-367 pubmed publisher
    ..Furthermore, we identify sortilin-1(Sort1), a known regulator of circulating low-density lipoprotein levels in humans, as a novel target of ..
  22. Zhu S, Tian H, Niu X, Wang J, Li X, Jiang N, et al. Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer. Oncogene. 2019;: pubmed publisher
    ..and activated downstream signaling leading to NED through activation of neurotensin receptor 1 (NTSR1) and neurotensin receptor 3 (NTSR3), but not neurotensin receptor 2 (NTSR2)...
  23. Kocarnik J, Pendergrass S, Carty C, Pankow J, Schumacher F, Cheng I, et al. Multiancestral analysis of inflammation-related genetic variants and C-reactive protein in the population architecture using genomics and epidemiology study. Circ Cardiovasc Genet. 2014;7:178-88 pubmed publisher
    ..Two SNPs in the CELSR2/PSRC1/SORT1 locus showed a potentially novel association with CRP: rs599839 (P=2.0×10(-6)) and rs646776 (P=3.1×10(-5))...
  24. Wang Y, Feng G, Xia Q, Hu Y, Xu Y, Xiong L, et al. Knockdown of α-synuclein in cerebral cortex improves neural behavior associated with apoptotic inhibition and neurotrophin expression in spinal cord transected rats. Apoptosis. 2016;21:404-20 pubmed publisher
    ..SNCA silence induced the upregulation of Bcl-2 and the downregulation of Bax, and the expression of NGF, BDNF and NT3 was substantially upregulated in cortical neurons...
  25. Vaughan S, Stanley O, Valdez G. Impact of Aging on Proprioceptive Sensory Neurons and Intrafusal Muscle Fibers in Mice. J Gerontol A Biol Sci Med Sci. 2017;72:771-779 pubmed publisher
    ..Our analysis also revealed normal levels of neurotrophin 3 (NT3) but dysregulated expression of the tyrosine kinase receptor C (TrkC) in aged muscles and DRGs, respectively...
  26. Oliveira Fernandes M, Tourtellotte W. Egr3-dependent muscle spindle stretch receptor intrafusal muscle fiber differentiation and fusimotor innervation homeostasis. J Neurosci. 2015;35:5566-78 pubmed publisher
    ..spindle remnants" persisted into adulthood, remained innervated by Ia-afferents, and expressed neurotrophin3 (NT3), which is required for Ia-afferent neuron survival...
  27. Canner J, Linsenmayer T, Kubilus J. Developmental regulation of trigeminal TRPA1 by the cornea. Invest Ophthalmol Vis Sci. 2014;56:29-36 pubmed publisher
    ..Similarly, the addition of exogenous neurotrophin-3 (NT3) protein to cultured ganglia increased the expression of TRPA1 more than 100-fold...
  28. Cramer J, Gustafsen C, Behrens M, Oliveira C, Pedersen J, Madsen P, et al. GGA autoinhibition revisited. Traffic. 2010;11:259-73 pubmed publisher
    ..have little or no influence and (iv) phosphorylation of GGA1 does not affect its conformation or binding to Sortilin and SorLA...
  29. . A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat Genet. 2011;43:339-44 pubmed publisher
    ..The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility. ..
  30. Evans S, Irmady K, Ostrow K, Kim T, Nykjaer A, Saftig P, et al. Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation. J Biol Chem. 2011;286:29556-67 pubmed publisher
    ..b>Sortilin is an intracellular chaperone that binds to the prodomain of BDNF to traffic it to the regulated secretory ..
  31. Akil H, Perraud A, Mélin C, Jauberteau M, Mathonnet M. Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival. PLoS ONE. 2011;6:e25097 pubmed publisher
    ..In parallel to the increase of BDNF secretion, sortilin, a protein acting as a neurotrophin transporter as well as a co-receptor for p75(NTR), was increased in the ..
  32. Li J, Matye D, Li T. Insulin resistance induces posttranslational hepatic sortilin 1 degradation in mice. J Biol Chem. 2015;290:11526-36 pubmed publisher
    ..The cellular trafficking receptor sortilin 1 (Sort1) was recently identified to transport apoB100 to the lysosome for degradation in the liver and thus ..
  33. Santos D, Gonzalez Perez F, Giudetti G, Micera S, Udina E, del Valle J, et al. Preferential Enhancement of Sensory and Motor Axon Regeneration by Combining Extracellular Matrix Components with Neurotrophic Factors. Int J Mol Sci. 2016;18: pubmed publisher
    ..Organotypic cultures with collagen, laminin and nerve growth factor (NGF)/neurotrophin-3 (NT3) or collagen, fibronectin and brain-derived neurotrophic factor (BDNF) selectively enhanced sensory neurite ..
  34. Hubacek J, Adamkova V, Lanska V, Dlouhá D. Polygenic hypercholesterolemia: examples of GWAS results and their replication in the Czech-Slavonic population. Physiol Res. 2017;66:S101-S111 pubmed
    ..g. APOE, APOB, LDL-R) and recognize the importance of new genetic determinants (e.g. within the CILP2 or SORT1 gene clusters)...
  35. Li J, Chen C, Li Y, Matye D, Wang Y, Ding W, et al. Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3T3-L1 adipocytes. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2924-2933 pubmed publisher
    b>Sortilin 1(Sort1) is a vesicle trafficking receptor that mediates protein sorting in the endocytic and exocytic pathways...
  36. Zsurger N, Mazella J, Vincent J. Solubilization and purification of a high affinity neurotensin receptor from newborn human brain. Brain Res. 1994;639:245-52 pubmed
    ..The purified receptor is a single protein chain of molecular weight 100 kDa as shown by gel filtration and by affinity labelling with [125I-Tyr3]neurotensin in the presence of the cross-linking agent disuccinimidyl suberate. ..
  37. Renno W, Khan K, Benov L. Is there a role for neurotrophic factors and their receptors in augmenting the neuroprotective effect of (-)-epigallocatechin-3-gallate treatment of sciatic nerve crush injury?. Neuropharmacology. 2016;102:1-20 pubmed publisher
    ..Analysis of BDNF, GDNF and NT3 neurotropic factors and Trk-B, Trk-C and NGFR-p75 receptors in neurons in the spinal cord of CRUSH and CRUSH +Â..
  38. Ruan C, Yang C, Li J, Luo H, Bobrovskaya L, Zhou X. Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior. Exp Neurol. 2016;281:99-108 pubmed publisher
    ..P75(NTR) and sortilin are co-receptors of proBDNF, however, the role of these receptors in mood regulation is not established...
  39. Sparks R, Jenkins J, Miner G, Wang Y, Guida W, Sparks C, et al. Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding. Biochem Biophys Res Commun. 2016;479:551-556 pubmed publisher
    b>Sortilin is a multi-ligand sorting receptor that interacts with B100-containing VLDL and LDL as well as other ligands including neurotensin (NT)...
  40. Wang J, Gao Y, Chen S, Duanmu C, Zhang J, Feng X, et al. The Effect of Repeated Electroacupuncture Analgesia on Neurotrophic and Cytokine Factors in Neuropathic Pain Rats. Evid Based Complement Alternat Med. 2016;2016:8403064 pubmed
    ..TNF-? mRNA, and IL-1 mRNA were detected by quantitative real-time PCR, and the proteins of BDNF, NGF, and NT3/4 were detected by Western blot...
  41. Zhang M, Zhang X, Kang J, Zhang H, Chen X, Liu N, et al. Matrine promotes NT3 expression in CNS cells in experimental autoimmune encephalomyelitis. Neurosci Lett. 2017;649:100-106 pubmed publisher
    Neurotrophin 3 (NT3) is a potent neurotrophic factor for promoting remyelination and recovery of neuronal function; upregulation of its expression in the central nervous system (CNS) is thus of major therapeutic importance for ..
  42. Lamiquiz Moneo I, Pérez Ruiz M, Jarauta E, Tejedor M, Bea A, Mateo Gallego R, et al. Single Nucleotide Variants Associated With Polygenic Hypercholesterolemia in Families Diagnosed Clinically With Familial Hypercholesterolemia. Rev Esp Cardiol (Engl Ed). 2018;71:351-356 pubmed publisher
    ..families (294 participants) and calculated cholesterol gene scores, derived from single nucleotide variants in SORT1, APOB, ABCG8, APOE and LDLR and lipoprotein(a) plasma concentration...
  43. Giorgi R, Chile T, Bello A, Reyes R, Fortes M, Machado M, et al. Expression of neurotensin and its receptors in pituitary adenomas. J Neuroendocrinol. 2008;20:1052-7 pubmed publisher
    ..In nonfunctioning adenomas, the NT immunoreactivity intensity was variable among the samples. NTR3 mRNA expression was observed in all examined samples and was higher in the adenomas, both functioning and ..
  44. Wilson C, Naves T, Vincent F, Melloni B, Bonnaud F, Lalloue F, et al. Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors. J Cell Sci. 2014;127:3983-97 pubmed publisher
    ..that the exosome release mechanism is closely linked to the multifaceted receptor sortilin (also called neurotensin receptor 3). Sortilin is already known to be important for cancer cell function...
  45. Zhang X, Chen K, Song C, Song C. Inhibition of long non-coding RNA IGF2AS has profound effect on inducing neuronal growth and protecting local-anesthetic induced neurotoxicity in dorsal root ganglion neurons. Biomed Pharmacother. 2016;82:298-303 pubmed publisher
    ..SiRNA-mediated IGF2AS inhibition promoted neuronal growth, and induced IGF2, BDNF and NT3 upregulations at both gene and protein expressions...
  46. Venkatesan R, Shim W, Yeo E, Kim S. Lactucopicrin potentiates neuritogenesis and neurotrophic effects by regulating Ca2+/CaMKII/ATF1 signaling pathway. J Ethnopharmacol. 2017;198:174-183 pubmed publisher
    ..Additionally, the levels of neurotrophins including NGF, BDNF, and NT3 were increased by treatment of lactucopicrin in C6 cells...
  47. Yao Q, Song R, Ao L, Zhan Q, Cleveland J, Yu X, et al. Over-expression of neurotrophin 3 in human aortic valves affected by calcific disease induces the osteogenic responses via the Trk-Akt pathway. Biochim Biophys Acta. 2015;1852:1940-9 pubmed publisher
    ..Among these genes, mRNA levels of neurotrophin 3 (NT3) increased by 2 fold...
  48. Buttenschøn H, Demontis D, Kaas M, Elfving B, Mølgaard S, Gustafsen C, et al. Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF. Transl Psychiatry. 2015;5:e677 pubmed publisher
    ..The aim of the present study was to widen this focus to sortilin, a receptor involved in neurotrophic signalling...
  49. Hodyl N, Crawford T, McKerracher L, Lawrence A, Pitcher J, Stark M. Antenatal steroid exposure in the late preterm period is associated with reduced cord blood neurotrophin-3. Early Hum Dev. 2016;101:57-62 pubmed publisher
    ..The reduced NT-3 may be a consequence of steroids inducing neuronal apoptosis, thereby reducing endogenous neuronal NT3 production, or be an action of steroids on other maternal or fetal NT-3 producing cells, which may then affect ..
  50. Kjolby M, Andersen O, Breiderhoff T, Fjorback A, Pedersen K, Madsen P, et al. Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Cell Metab. 2010;12:213-23 pubmed publisher
    ..3. This locus covers three genes: SORT1, CELSR2, and PSRC1. We demonstrate that sortilin, encoded by SORT1, is an intracellular sorting receptor for apolipoprotein (apo) B100...
  51. Connors K, Karlos A, Gnatiuk E, Shearer J, Reimer R, Hittel D. SORT1 protective allele is associated with attenuated postprandial: lipaemia in young adults. Circ Cardiovasc Genet. 2014;7:576-82 pubmed publisher
    ..We report a novel association between the SORT1 1p13 locus and extent of postprandial lipaemia...
  52. Johnson I, Parkinson Lawrence E, Keegan H, Spillane C, Barry O Crowley J, Watson W, et al. Endosomal gene expression: a new indicator for prostate cancer patient prognosis?. Oncotarget. 2015;6:37919-29 pubmed publisher
    ..The expression of APPL1, RAB5A, EEA1, PDCD6IP, NOX4 and SORT1 were altered in malignant patient tissue, when compared to indolent and normal prostate tissue...
  53. Martiñón S, García Vences E, Toscano Tejeida D, Flores Romero A, Rodriguez Barrera R, Ferrusquia M, et al. Long-term production of BDNF and NT-3 induced by A91-immunization after spinal cord injury. BMC Neurosci. 2016;17:42 pubmed publisher
    ..In the third experiment, we explored the amount of BDNF and NT3 at the site of injury in the chronic phase of rats subjected to either SC-contusion (SCC; moderate or severe) or SC-..
  54. Sheldrick A, Camara S, Ilieva M, Riederer P, Michel T. Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) levels in post-mortem brain tissue from patients with depression compared to healthy individuals - a proof of concept study. Eur Psychiatry. 2017;46:65-71 pubmed publisher
    ..Therefore, we examined the concentration of brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) in different brain regions (cortex, cingulate gyrus, thalamus, hippocampus, putamen and nucleus caudatus) of 21 ..
  55. Kanzaki M. [Sortilin, sorting disorders, and life-style diseases]. Seikagaku. 2011;83:1035-9 pubmed
  56. Duan H, Ge W, Zhang A, Xi Y, Chen Z, Luo D, et al. Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury. Proc Natl Acad Sci U S A. 2015;112:13360-5 pubmed publisher
    ..We discovered that neurotrophin-3 (NT3)-loaded chitosan provided an excellent microenvironment to facilitate nerve growth, new neurogenesis, and ..
  57. Romero F, Marina M, Pieckenstain F. Novel components of leaf bacterial communities of field-grown tomato plants and their potential for plant growth promotion and biocontrol of tomato diseases. Res Microbiol. 2016;167:222-33 pubmed publisher
    ..Pseudomonas veronii (isolates BT4 and NT2), Pseudomonas rhodesiae (isolate BT2) and Pseudomonas cichorii (isolate NT3). After seed inoculation, BT2, BT4, MT3, MT8, NT2 and NT6 were re-isolated from leaf extracts...
  58. Mizsei E, Jablonski D, Roussos S, Dimaki M, Ioannidis Y, Nilson G, et al. Nuclear markers support the mitochondrial phylogeny of <i>Vipera</i> <i>ursinii-renardi</i> complex (Squamata: Viperidae) and species status for the Greek meadow viper. Zootaxa. 2017;4227:zootaxa.4227.1.4 pubmed publisher
    ..We present here new analyses of three nuclear markers (BDNF, NT3, PRLR; a first for studies of meadow and steppe vipers) as well as analyses of newly obtained mitochondrial DNA ..
  59. Keeler A, Suo D, Park J, Deppmann C. Delineating neurotrophin-3 dependent signaling pathways underlying sympathetic axon growth along intermediate targets. Mol Cell Neurosci. 2017;82:66-75 pubmed publisher
    Postganglionic sympathetic neurons detect vascular derived neurotrophin 3 (NT3) via the axonally expressed receptor tyrosine kinase, TrkA, to promote chemo-attraction along intermediate targets...
  60. Story G, DiCarlo S, Rodenbaugh D, Dluzen D, Kucera J, Maron M, et al. Inactivation of one copy of the mouse neurotrophin-3 gene induces cardiac sympathetic deficits. Physiol Genomics. 2000;2:129-36 pubmed
    Whether two copies of the neurotrophin-3 (NT3) gene are necessary for proper development of cardiac sympathetic innervation was investigated in mice carrying a targeted inactivation of the NT3 gene...
  61. Mari M, Bujny M, Zeuschner D, Geerts W, Griffith J, Petersen C, et al. SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. Traffic. 2008;9:380-93 pubmed
    ..Recently, the multi-ligand receptor sortilin has also been implicated in this transport, but the transport carriers involved herein have not been identified...
  62. Zhou B, Zhuang J, Gu D, Wang H, Cebotaru L, Guggino W, et al. WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway. J Am Soc Nephrol. 2010;21:82-92 pubmed publisher
    ..Here, we investigated the effect of the lysosomal targeting receptor sortilin on NCC expression and degradation...
  63. Mufson E, Wuu J, Counts S, Nykjaer A. Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease. Neurosci Lett. 2010;471:129-33 pubmed publisher
    ..and exhibits pro-apoptotic properties when bound to the p75(NTR) neurotrophin receptor in the presence of sortilin, a Vps10p domain trafficking protein...
  64. Demont Y, Corbet C, Page A, Ataman Onal Y, Choquet Kastylevsky G, Fliniaux I, et al. Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein. J Biol Chem. 2012;287:1923-31 pubmed publisher
    ..active polypeptide able to induce apoptosis in neuronal cells, via the neurotrophin receptor p75(NTR) and the sortilin receptor...
  65. Larsen J, Hermey G, Sørensen E, Prabakaran T, Christensen E, Gliemann J, et al. Human sorCS1 binds sortilin and hampers its cellular functions. Biochem J. 2014;457:277-88 pubmed publisher
    b>Sortilin and sorCS1 [sortilin-related Vps10p (vacuolar protein sorting/targeting protein 10) domain-containing receptor 1], both members of the Vps10p-D (Vps10p-domain) receptor family, are synthesized as precursor proteins and are ..
  66. Breitling C, Gross A, Büttner P, Weise S, Schleinitz D, Kiess W, et al. Genetic Contribution of Variants near SORT1 and APOE on LDL Cholesterol Independent of Obesity in Children. PLoS ONE. 2015;10:e0138064 pubmed publisher
    To assess potential effects of variants in six lipid modulating genes (SORT1, HMGCR, MLXIPL, FADS2, APOE and MAFB) on early development of dyslipidemia independent of the degree of obesity in children, we investigated their association ..
  67. Hermey G, Keat S, Madsen P, Jacobsen C, Petersen C, Gliemann J. Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells. J Biol Chem. 2003;278:7390-6 pubmed
    ..Like the Vps10p-domain receptor family members sortilin and sorLA, sorCS1 is synthesized as a proreceptor that is converted in late Golgi compartments by furin-mediated ..
  68. Keebler M, Sanders C, Surti A, Guiducci C, Burtt N, Kathiresan S. Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III. Circ Cardiovasc Genet. 2009;2:238-43 pubmed publisher
    ..At 5 loci (1p13 near CELSR2/PSRC1/SORT1, HMGCR, CETP, LPL, and APOA5), the index SNP was associated with low-density lipoprotein cholesterol, high-density ..
  69. Zhou Y, Hong S, Yang Q, Yin R, Cao X, Chen W. Association of variants in CELSR2-PSRC1-SORT1 with risk of serum lipid traits, coronary artery disease and ischemic stroke. Int J Clin Exp Pathol. 2015;8:9543-51 pubmed
    ..Our study was to assess the association of CELSR2-PSRC1-SORT1 rs599839, rs464218 and rs6698443 SNPs and serum lipid levels and the risk of CAD and IS...
  70. Martin S, Vincent J, Mazella J. Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia. J Neurosci. 2003;23:1198-205 pubmed
    ..This demonstrates that the neurotensin receptor-3 is functional and mediates the migratory actions of neurotensin. ..
  71. Paiardini A, Caputo V. Insights into the interaction of sortilin with proneurotrophins: a computational approach. Neuropeptides. 2008;42:205-14 pubmed publisher
    b>Sortilin is a member of the recently discovered family of type-1 transmembrane Vps10p-domain receptors, which are expressed in several tissues, including brain and spinal chord...
  72. Lee W, Almeida S, Prudencio M, Caulfield T, Zhang Y, Tay W, et al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Hum Mol Genet. 2014;23:1467-78 pubmed publisher
    ..Recent discoveries demonstrating sortilin (SORT1) is a neuronal receptor for PGRN endocytosis and a determinant of plasma PGRN levels portend the ..
  73. Arvind P, Nair J, Jambunathan S, Kakkar V, Shanker J. CELSR2-PSRC1-SORT1 gene expression and association with coronary artery disease and plasma lipid levels in an Asian Indian cohort. J Cardiol. 2014;64:339-46 pubmed publisher
    ..the relationship between rs599839 and rs646776 single nucleotide polymorphisms (SNPs) present in the CELSR2-PSRC1-SORT1 gene cluster, candidate gene expression, and their association with CAD and circulating lipid levels in a ..
  74. Reuter E, Weber J, Paterka M, Ploen R, Breiderhoff T, van Horssen J, et al. Role of Sortilin in Models of Autoimmune Neuroinflammation. J Immunol. 2015;195:5762-9 pubmed publisher
    The proneurotrophin receptor sortilin is a protein with dual functions, being involved in intracellular protein transport, as well as cellular signal transduction...
  75. Takatsu H, Katoh Y, Shiba Y, Nakayama K. Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains. J Biol Chem. 2001;276:28541-5 pubmed
    ..with acidic dileucine sequences found in the cytoplasmic domains of TGN-localized sorting receptors such as sortilin and mannose 6-phosphate receptor...
  76. Soundara Rajan T, Scionti D, Diomede F, Piattelli A, Bramanti P, Mazzon E, et al. Prolonged Expansion Induces Spontaneous Neural Progenitor Differentiation from Human Gingiva-Derived Mesenchymal Stem Cells. Cell Reprogram. 2017;: pubmed publisher
    ..repressors TP53 and p21, whereas Western blot results revealed the expression of neurotrophic factors BDNF and NT3 at passage 41...
  77. Larsen J, Hansen M, Møller B, Madsen P, Scheller J, Nielsen M, et al. Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer. Mol Cell Biol. 2010;30:4175-87 pubmed publisher
    b>Sortilin is a member of the Vps10p domain family of neuropeptide and neurotrophin binding neuronal receptors...
  78. Mohagheghi F, Prudencio M, Stuani C, Cook C, Jansen West K, Dickson D, et al. TDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor. Hum Mol Genet. 2016;25:534-45 pubmed publisher
    ..into the complexity of the RNA-binding protein network by demonstrating that the inclusion of exon 17b in the SORT1 mRNA, a pathologically relevant splicing event known to be regulated by TDP-43, is also considerably affected by ..
  79. Ogawa K, Ueno T, Iwasaki T, Kujiraoka T, Ishihara M, Kunimoto S, et al. Soluble sortilin is released by activated platelets and its circulating levels are associated with cardiovascular risk factors. Atherosclerosis. 2016;249:110-5 pubmed publisher
    b>Sortilin is involved multilaterally in the development of atherosclerosis...
  80. Warren C, O Sullivan J, Friesen M, Becker C, Zhang X, Liu P, et al. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 2017;20:547-557.e7 pubmed publisher
    ..rs12740374 and lipid accumulation and gene expression in differentiated hepatocytes, in particular, expression of SORT1, CELSR2, and PSRC1, consistent with previous analyses of this variant using other approaches...
  81. Venkat S, Linstedt A. Manganese-induced trafficking and turnover of GPP130 is mediated by sortilin. Mol Biol Cell. 2017;28:2569-2578 pubmed publisher
    ..exit of GPP130 from the trans-Golgi network (TGN) toward lysosomes is mediated by the sorting receptor sortilin interacting with the lumenal stem domain of GPP130...
  82. Coutinho M, Bourbon M, Prata M, Alves S. Sortilin and the risk of cardiovascular disease. Rev Port Cardiol. 2013;32:793-9 pubmed publisher
    ..teams seeking to clarify the biological basis of this association, who succeeded in proving that SORT1, encoding sortilin, was the gene in the 1p13 locus involved in LDL metabolism...
  83. Campagnolo L, Costanza G, Francesconi A, Arcuri G, Moscatelli I, Orlandi A. Sortilin expression is essential for pro-nerve growth factor-induced apoptosis of rat vascular smooth muscle cells. PLoS ONE. 2014;9:e84969 pubmed publisher
    b>Sortilin, a member of the Vps10p-domain receptor family, has been demonstrated a key regulator in mediating cellular response to pro-neurotrophins...
  84. Sánchez E, Bergareche A, Krebs C, Gorostidi A, Makarov V, Ruiz Martinez J, et al. SORT1 Mutation Resulting in Sortilin Deficiency and p75(NTR) Upregulation in a Family With Essential Tremor. ASN Neuro. 2015;7: pubmed publisher
    ..The p.Gly171Ala mutation was shown not only to impair the expression of its encoding protein sortilin but also the mRNA levels of its binding partner p75 neurotrophin receptor that is known to be implicated in brain ..
  85. Tonjes A, Scholz M, Krüger J, Krause K, Schleinitz D, Kirsten H, et al. Genome wide meta-analysis identifies novel determinants of circulating serum progranulin. Hum Mol Genet. 2017;: pubmed publisher
    ..nucleotide polymorphisms (SNPs) at three loci reached study-wide significance (rs660240 in CELSR2-PSRC1-MYBPHL-SORT1, rs4747197 in CDH23-PSAP and rs5848 in GRN) explaining 19.4%/15...
  86. Lin B, Pilch P, Kandror K. Sortilin is a major protein component of Glut4-containing vesicles. J Biol Chem. 1997;272:24145-7 pubmed
    ..cloning that glycoprotein 110, the last unidentified major protein component of Glut4-containing vesicles, is sortilin, a novel type I receptor-like protein recently cloned from human brain (Petersen, C. M., Nielsen, M. S...
  87. Pallesen L, Vaegter C. Sortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins. Mol Neurobiol. 2012;45:379-87 pubmed publisher
    b>Sortilin and SorLA are members of the Vps10p domain receptor family, the Sortilins, which comprise five type I transmembrane receptors differentially expressed in neuronal tissues of the central and peripheral nervous system...
  88. Prabakaran T, Nielsen R, Satchell S, Mathieson P, Feldt Rasmussen U, Sørensen S, et al. Mannose 6-phosphate receptor and sortilin mediated endocytosis of ?-galactosidase A in kidney endothelial cells. PLoS ONE. 2012;7:e39975 pubmed publisher
    ..Affinity purification studies using ?-Gal A resins identified M6PR and sortilin as ?-Gal A receptors in cultured glomerular endothelial cells...
  89. Coutinho M, Prata M, Alves S. A shortcut to the lysosome: the mannose-6-phosphate-independent pathway. Mol Genet Metab. 2012;107:257-66 pubmed publisher
    ..the two that are mediated by the M6P alternative receptors, lysosomal integral membrane protein (LIMP-2) and sortilin, have gained unequivocal support...
  90. Karlos A, Shearer J, Gnatiuk E, Onyewu C, Many G, Hoffman E, et al. Effect of the SORT1 low-density lipoprotein cholesterol locus is sex-specific in a fit, Canadian young-adult population. Appl Physiol Nutr Metab. 2013;38:188-93 pubmed publisher
    The SORT1 locus was originally identified by genome-wide association studies of low-density lipoprotein cholesterol (LDL-C) in adults...
  91. Faulkner S, Jobling P, Rowe C, Rodrigues Oliveira S, Roselli S, Thorne R, et al. Neurotrophin Receptors TrkA, p75NTR, and Sortilin Are Increased and Targetable in Thyroid Cancer. Am J Pathol. 2018;188:229-241 pubmed publisher
    ..TrkA (also called NTRK1), the common neurotrophin receptor p75NTR, and the proneurotrophin receptor sortilin were analyzed with immunohistochemistry in a cohort of thyroid cancers (n = 128) and compared with adenomas and ..
  92. Eriste E, Norberg A, Nepomuceno D, Kuei C, Kamme F, Tran D, et al. A novel form of neurotensin post-translationally modified by arginylation. J Biol Chem. 2005;280:35089-97 pubmed
    ..We expressed the intracellular receptor NTR3 as a soluble protein secreted into the cell culture medium, which allowed characterization of its R-NT and ..