SORBS2

Summary

Gene Symbol: SORBS2
Description: sorbin and SH3 domain containing 2
Alias: ARGBP2, PRO0618, sorbin and SH3 domain-containing protein 2, Arg binding protein 2, Arg/Abl-interacting protein 2, arg-binding protein 2
Species: human
Products:     SORBS2

Top Publications

  1. Roignot J, Taieb D, Suliman M, Dusetti N, Iovanna J, Soubeyran P. CIP4 is a new ArgBP2 interacting protein that modulates the ArgBP2 mediated control of WAVE1 phosphorylation and cancer cell migration. Cancer Lett. 2010;288:116-23 pubmed publisher
    b>ArgBP2 is a multi-adapter protein involved in signal transduction associated to the cytoskeleton and was shown to regulate the migration and adhesion of pancreatic cancer cells thereby modulating their tumorigenicity...
  2. Kawabe H, Hata Y, Takeuchi M, Ide N, Mizoguchi A, Takai Y. nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP). J Biol Chem. 1999;274:30914-8 pubmed
    ..in the middle region, and three src homology (SH) 3 domains in the C terminus and was homologous to the ponsin/ArgBP2/vinexin family proteins. We named this protein nArgBP2 because it was the most homologous to ArgBP2...
  3. Backsch C, Rudolph B, Steinbach D, Scheungraber C, Liesenfeld M, Häfner N, et al. An integrative functional genomic and gene expression approach revealed SORBS2 as a putative tumour suppressor gene involved in cervical carcinogenesis. Carcinogenesis. 2011;32:1100-6 pubmed publisher
    ..The two most promising genes, SORBS2 and CALML5, were expressed ectopically in various cell lines in order to analyse their functional activity...
  4. Wang B, Golemis E, Kruh G. ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks. J Biol Chem. 1997;272:17542-50 pubmed
    ..A novel Arg/Abl-binding protein, ArgBP2, was isolated using a segment of the Arg COOH-terminal domain as bait in the yeast two-hybrid system...
  5. Murase K, Ito H, Kanoh H, Sudo K, Iwamoto I, Morishita R, et al. Cell biological characterization of a multidomain adaptor protein, ArgBP2, in epithelial NMuMG cells, and identification of a novel short isoform. Med Mol Morphol. 2012;45:22-8 pubmed publisher
    b>ArgBP2 is a member of the SoHo (sorbin-homology) family of adaptor proteins believed to play roles in cell adhesion, cytoskeletal organization, and signaling. We show here a novel splicing isoform of ArgBP2, i.e...
  6. Sanger J, Wang J, Gleason L, Chowrashi P, Dube D, Mittal B, et al. Arg/Abl-binding protein, a Z-body and Z-band protein, binds sarcomeric, costameric, and signaling molecules. Cytoskeleton (Hoboken). 2010;67:808-23 pubmed publisher
    b>ArgBP2 (Arg/Abl-Binding Protein) is expressed at high levels in the heart and is localized in the Z-bands of mature myofibrils...
  7. Taieb D, Roignot J, Andre F, Garcia S, Masson B, Pierres A, et al. ArgBP2-dependent signaling regulates pancreatic cell migration, adhesion, and tumorigenicity. Cancer Res. 2008;68:4588-96 pubmed publisher
    ..Here, we describe that the scaffold protein ArgBP2 is repressed during oncogenic transformation of the pancreas...
  8. Rönty M, Taivainen A, Moza M, Kruh G, Ehler E, Carpen O. Involvement of palladin and alpha-actinin in targeting of the Abl/Arg kinase adaptor ArgBP2 to the actin cytoskeleton. Exp Cell Res. 2005;310:88-98 pubmed
    ..b>ArgBP2 is a multi-domain scaffolding protein which shares both the tissue distribution and subcellular localization with ..
  9. Soubeyran P, Barac A, Szymkiewicz I, Dikic I. Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl. Biochem J. 2003;370:29-34 pubmed
    ..We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl...

More Information

Publications45

  1. Haglund K, Ivankovic Dikic I, Shimokawa N, Kruh G, Dikic I. Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. J Cell Sci. 2004;117:2557-68 pubmed
    ..We found that Pyk2 and Cbl interacted with the adaptor protein ArgBP2, which also bound to flotillin-1, a component of lipid raft microdomains...
  2. Lu P, Qiao J, He W, Wang J, Jia Y, Sun Y, et al. Genome-wide gene expression profile analyses identify CTTN as a potential prognostic marker in esophageal cancer. PLoS ONE. 2014;9:e88918 pubmed publisher
    ..deregulated genes including four overexpressed (CTTN, DMRT2, MCM10 and SCYA26) and two underexpressed (HMGCS2 and SORBS2) were subsequently verified, which can be served as biomarkers for ESCC...
  3. Dixon D, Choi J, El Ghazali A, Park S, Roos K, Jordan M, et al. Loss of muscleblind-like 1 results in cardiac pathology and persistence of embryonic splice isoforms. Sci Rep. 2015;5:9042 pubmed publisher
    ..Capn3, Sirt2, Csda, sarcomere and cytoskeleton organization and function, Trim55, Mapt, Pdlim3, Pdlim5, Sorbs1, Sorbs2, Fhod1, Spag9 and structural components of the sarcomere, Myom1, Tnnt2, Zasp...
  4. Keller M, Hopp L, Liu X, Wohland T, Rohde K, Cancello R, et al. Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity. Mol Metab. 2017;6:86-100 pubmed publisher
    ..Further, we identified six adipose tissue depot-specific genes (HAND2, HOXC6, PPARG, SORBS2, CD36, and CLDN1). The effects were further supported in additional independent cohorts...
  5. Rowther F, Wei W, Dawson T, Ashton K, Singh A, Madiesse Timchou M, et al. Cyclic nucleotide phosphodiesterase-1C (PDE1C) drives cell proliferation, migration and invasion in glioblastoma multiforme cells in vitro. Mol Carcinog. 2016;55:268-79 pubmed publisher
    ..Up-regulation of at least one of this gene set (IL8, CXCL2, FOSB, NFE2L3, SUB1, SORBS2, WNT5A, and MMP1) in TCGA GBM cohorts is associated with worse outcome and PDE1C silencing down-regulated their ..
  6. Wales S, Hashemi S, Blais A, McDermott J. Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling. Nucleic Acids Res. 2014;42:11349-62 pubmed publisher
    ..Several up-regulated (Tprg, Mctp2, Kitl, Prrx1, Dusp6) and down-regulated (Atp1a2, Hspb7, Tmem182, Sorbs2, Lmod3) MEF2A target genes were chosen for further investigation...
  7. Wang C, Qu B, Wang Z, Ju J, Wang Y, Wang Z, et al. Proteomic identification of differentially expressed proteins in vascular wall of patients with ruptured intracranial aneurysms. Atherosclerosis. 2015;238:201-6 pubmed publisher
    ..0 and 8.6 fold up-regulated, respectively, in IA, while Sorbin and SH3 domain-containing protein 2 (SORBS2), involved in signaling complex assembly, was 12.1 fold down-regulated...
  8. Bang C, Batkai S, Dangwal S, Gupta S, Foinquinos A, Holzmann A, et al. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest. 2014;124:2136-46 pubmed publisher
    ..Proteome profiling identified sorbin and SH3 domain-containing protein 2 (SORBS2) and PDZ and LIM domain 5 (PDLIM5) as miR-21* targets, and silencing SORBS2 or PDLIM5 in cardiomyocytes induced ..
  9. Zagajewska K, Piatkowska M, Goryca K, Bałabas A, Kluska A, Paziewska A, et al. GWAS links variants in neuronal development and actin remodeling related loci with pseudoexfoliation syndrome without glaucoma. Exp Eye Res. 2018;168:138-148 pubmed publisher
    ..LOXL1 variant rs2165241, nine other SNPs were located within gene regions, including in OR11L1, CD80, TNIK, CADM2, SORBS2, RNF180, FGF14, FMN1, and RBFOX1 genes. None of these associations with PEXS has previously been reported...
  10. Molck M, Simioni M, Paiva Vieira T, Sgardioli I, Paoli Monteiro F, Souza J, et al. Genomic imbalances in syndromic congenital heart disease. J Pediatr (Rio J). 2017;93:497-507 pubmed publisher
    ..1 and 706kb duplication in 2p22.3). Genes inside the CNV regions found in this study, such as IRX4, BMPR1A, SORBS2, ID2, ROCK2, E2F6, GATA4, SOX7, SEMAD6D, FBN1, and LTPB1 are known to participate in cardiac development and could ..
  11. Ramirez Ardila D, Ruigrok Ritstier K, Helmijr J, Look M, Van Laere S, Dirix L, et al. LRG1 mRNA expression in breast cancer associates with PIK3CA genotype and with aromatase inhibitor therapy outcome. Mol Oncol. 2016;10:1363-73 pubmed publisher
    ..of 3 miRs (miR-449a, miR-205-5p, miR-301a-3p) and 9 mRNAs (CCNO, FAM81B, LRG1, NEK10, PLCL1, PGR, SERPINA3, SORBS2, VTCN1) was related to the PIK3CA status in both datasets...
  12. Wang H, Bei Y, Shen S, Huang P, Shi J, Zhang J, et al. miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2. J Mol Cell Cardiol. 2016;94:43-53 pubmed publisher
    ..Meanwhile, our data showed that SH3 domain-containing protein 2 (SORBS2) was inversely correlated with miR-21-3p expression level in mice hearts, and was repressed in hearts challenged ..
  13. Zhang Q, Gao X, Li C, Feliciano C, Wang D, Zhou D, et al. Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice. J Neurosci. 2016;36:2247-60 pubmed publisher
    ..However, the neurobiological function of SORBS2 in the brain is unknown. The SORBS2 gene encodes ArgBP2 (Arg/c-Abl kinase binding protein 2) protein in non-neuronal tissues and is alternatively spliced in the brain to ..
  14. Hallock P, Chin S, Blais S, Neubert T, Glass D. Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation. Mol Cell Biol. 2016;36:262-70 pubmed publisher
    ..the roles of Crk/CrkL, we identified CrkL binding proteins using mass spectrometry and have identified Sorbs1 and Sorbs2 as two functionally redundant proteins that associate with the initiating MuSK/Dok-7/Crk/CrkL complex, regulate ..
  15. Tong Y, Li Y, Gu H, Wang C, Liu F, Shao Y, et al. HSF1, in association with MORC2, downregulates ArgBP2 via the PRC2 family in gastric cancer cells. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1104-1114 pubmed publisher
    Arg Kinase-binding protein 2 (ArgBP2) is considered to be a scaffold protein that coordinates multiple signaling pathways converging on cell adhesion and actin cytoskeletal organization...
  16. Braun G, Kuszka A, Dau C, Kriz W, Moeller M. Interaction of atypical cadherin Fat1 with SoHo adaptor proteins CAP/ponsin and ArgBP2. Biochem Biophys Res Commun. 2016;472:88-94 pubmed publisher
    ..Specifically, we found SoHo proteins CAP/ponsin-1 and -2 (Sorbs1) and ArgBP2 (Sorbs2) to interact with the cytoplasmic domain of Fat1...
  17. Zhao L, Wang W, Huang S, Yang Z, Xu L, Yang Q, et al. The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts. Genome Biol. 2018;19:35 pubmed publisher
    ..In this study, we identify that the RBP sorbin and SH3 domain containing 2 (SORBS2) is a potent suppressor of ovarian cancer metastatic colonization...
  18. Lamberti A, Sanges C, Chambery A, Migliaccio N, Rosso F, Di Maro A, et al. Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. Biochimie. 2011;93:1738-46 pubmed publisher
    ..contained sorbin, a polypeptide of 153 amino acids present in SH3 domain-containing adaptor proteins, such as SORBS2. This interaction was also assessed by Western blot on immunoprecipitate from mouse embryo or H1355 cell lysates ..
  19. Tong Y, Li Y, Gu H, Wang C, Liu F, Shao Y, et al. Microchidia protein 2, MORC2, downregulates the cytoskeleton adapter protein, ArgBP2, via histone methylation in gastric cancer cells. Biochem Biophys Res Commun. 2015;467:821-7 pubmed publisher
    b>ArgBP2 is an adapter protein that plays an important role in actin-dependent processes such as cell adhesion and migration. However, its function and regulation mechanisms in gastric cancer have not yet been investigated...
  20. Kioka N. [A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2]. Seikagaku. 2002;74:1356-60 pubmed
  21. Hand D, Eiden L. Human sorbin is generated via splicing of an alternative transcript from the ArgBP2 gene locus. Peptides. 2005;26:1278-82 pubmed
    We demonstrate that the human sorbin polypeptide is generated via splicing of an alternative transcript from the ArgBP2 gene locus...
  22. Zucconi A, Dente L, Santonico E, Castagnoli L, Cesareni G. Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1. J Mol Biol. 2001;307:1329-39 pubmed
    ..Two different proline-rich regions of the p21-activated protein kinase 1 (Pak1) and WAVE/SCAR2 protein retrieve from the library different proteins containing SH3 or WW domains. ..
  23. Lee J, Cheng R, Vardarajan B, Lantigua R, Reyes Dumeyer D, Ortmann W, et al. Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics. JAMA Neurol. 2015;72:1043-51 pubmed publisher
    ..In the confirmation stage, genewise analysis identified SNX25, PDLIM3, and 3 SH3 domain genes (SORBS2, SH3RF3, and NPHP1) to be significantly associated with LOAD...
  24. Liesenfeld M, Mosig S, Funke H, Jansen L, Runnebaum I, Dürst M, et al. SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes. BMC Cancer. 2013;13:507 pubmed publisher
    ..Ten of these genes could be validated in biopsies by RT-PCR. Of interest is the novel finding that SORBS2 and TLR3 can induce senescence in primary human fibroblasts and keratinocytes but not in HPV-immortalized cell ..
  25. de Bock C, Hughes M, Snyder K, Alley S, Sadeqzadeh E, Dun M, et al. Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels. FEBS Lett. 2017;591:667-678 pubmed publisher
    ..We conclude that SH3RF1 acts as a negative post-translational regulator of FAT1 levels. ..
  26. Kärkkäinen S, Hiipakka M, Wang J, Kleino I, Vähä Jaakkola M, Renkema G, et al. Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. EMBO Rep. 2006;7:186-91 pubmed
  27. Shen T, Li Y, Yang L, Liang S, Ba G, Fu Q. [Expression and localization of ArgBP2 in osteosarcoma MG-63 cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012;28:237-9 pubmed
    ..Using pcDNA3.1-hArgBP2 as a template, we obtained human ArgBP2 coding sequence by polymerase chain reaction (PCR) amplification and cloned it into the eukaryotic expression ..
  28. Xu Y, Wu R, Gu Y, Yang Y, Yang M, Nwariaku F, et al. Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. J Biol Chem. 2002;277:28051-7 pubmed
    ..We speculate that endothelial cells may target endogenous oxidant production to specific sites critical to cytokine signaling as a mechanism for increasing signal specificity and decreasing toxicity of these reactive species. ..
  29. Anekal P, Yong J, Manser E. Arg kinase-binding protein 2 (ArgBP2) interaction with α-actinin and actin stress fibers inhibits cell migration. J Biol Chem. 2015;290:2112-25 pubmed publisher
    Cell migration requires dynamic remodeling of the actomyosin network. We report here that an adapter protein, ArgBP2, is a component of α-actinin containing stress fibers and inhibits migration...
  30. Roignot J, Bonacci T, Ghigo E, Iovanna J, Soubeyran P. Oligomerization and phosphorylation dependent regulation of ArgBP2 adaptive capabilities and associated functions. PLoS ONE. 2014;9:e87130 pubmed publisher
    ArgBP2 (Arg-Binding Protein 2/SORBS2) is an adaptor protein involved in cytoskeleton associated signal transduction, thereby regulating cell migration and adhesion...
  31. Winham S, Mehner C, Heinzen E, Broderick B, Stallings Mann M, Nassar A, et al. NanoString-based breast cancer risk prediction for women with sclerosing adenosis. Breast Cancer Res Treat. 2017;166:641-650 pubmed publisher
    ..univariate associations within each of the five folds consistently identified genes DLK2, EXOC6, KIT, RGS12, and SORBS2 as significant; a model with only these five genes showed cross-validated ROC-AUC of 0...
  32. Ichikawa T, Kita M, Matsui T, Nagasato A, Araki T, Chiang S, et al. Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation. J Cell Sci. 2017;130:3517-3531 pubmed publisher
    Vinexin, c-Cbl associated protein (CAP) and Arg-binding protein 2 (ArgBP2) constitute an adaptor protein family called the vinexin (SORBS) family that is targeted to focal adhesions (FAs)...
  33. Fredriksson Lidman K, Van Itallie C, Tietgens A, Anderson J. Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells. PLoS ONE. 2017;12:e0185448 pubmed publisher
    b>SORBS2 is a scaffolding protein associated with Abl/Arg non-receptor tyrosine kinase pathways and is known to interact with actin and several other cytoskeletal proteins in various cell types...
  34. Kakimoto Y, Ito S, Abiru H, Kotani H, Ozeki M, Tamaki K, et al. Sorbin and SH3 domain-containing protein 2 is released from infarcted heart in the very early phase: proteomic analysis of cardiac tissues from patients. J Am Heart Assoc. 2013;2:e000565 pubmed publisher
    ..In addition to known biomarkers, the sarcoplasmic protein sorbin and SH3 domain-containing protein 2 (SORBS2) was greatly reduced in infarcted myocardia...
  35. Robin J, Ludlow A, Batten K, Gaillard M, Stadler G, Magdinier F, et al. SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy. Genome Res. 2015;25:1781-90 pubmed publisher
    ..the existence of a telomere loop at the 4q35 locus involving the sorbin and SH3 domain-containing protein 2 gene, SORBS2, a skeletal muscle protein using a modification of the chromosome conformation capture method...
  36. Kimura A, Baumann C, Chiang S, Saltiel A. The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. Proc Natl Acad Sci U S A. 2001;98:9098-103 pubmed
    ..This domain is present in two other proteins, vinexin and ArgBP2. Vinexin also interacted with flotillin, and deletion of its SoHo domain similarly blocked flotillin binding...