SOHLH2

Summary

Gene Symbol: SOHLH2
Description: spermatogenesis and oogenesis specific basic helix-loop-helix 2
Alias: SOSF2, SPATA28, TEB1, bHLHe81, spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2, spermatogenesis associated 28, testicular secretory protein Li 50, testicular secretory protein Li 51
Species: human
Products:     SOHLH2

Top Publications

  1. Wang J, Yu X, Wu R, Sun X, Cheng S, Ge W, et al. Starvation during pregnancy impairs fetal oogenesis and folliculogenesis in offspring in the mouse. Cell Death Dis. 2018;9:452 pubmed publisher
    ..follicles and the expression of oocyte genes critically involved in folliculogenesis such as Nobox, Lhx8 and Sohlh2 in the 3 days post partum (dpp) starved ovaries were found...
  2. Desimio M, Campolo F, Dolci S, De Felici M, Farini D. SOHLH1 and SOHLH2 directly down-regulate STIMULATED BY RETINOIC ACID 8 (STRA8) expression. Cell Cycle. 2015;14:1036-45 pubmed publisher
    ..In this study, we demonstrate a direct negative control of SOHLH1 and SOHLH2, 2 germ cell specific bHLH transcription factors, on Stra8 expression...
  3. Zhang X, Zhang H, Gao Q, Ji S, Bing L, Hao J. Sohlh2 inhibits the apoptosis of mouse primordial follicle oocytes via C-kit/PI3K/Akt/Foxo3a signalling pathway. Reprod Biomed Online. 2015;30:514-21 pubmed publisher
    ..signalling pathway initiated primordial follicle growth and prevented oocyte apoptosis via up-regulation of Sohlh2 and receptor for kit ligand (c-kit). The mechanism underlying this process was not fully elucidated...
  4. Tran D, Jung E, Yoo Y, Ahn C, Kang H, Choi K, et al. Depletion of follicles accelerated by combined exposure to phthalates and 4-vinylcyclohexene diepoxide, leading to premature ovarian failure in rats. Reprod Toxicol. 2018;80:60-67 pubmed publisher
    ..The expressions of Amh and Sohlh2 were significantly decreased in the combination groups...
  5. Nickkholgh B, Korver C, van Daalen S, van Pelt A, Repping S. AZFc deletions do not affect the function of human spermatogonia in vitro. Mol Hum Reprod. 2015;21:553-62 pubmed publisher
    ..and activator of transcription 3 (STAT3), spermatogenesis and oogenesis specific basic helix-loophelix 2 (SOHLH2), v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) and synaptonemal complex protein 3 (SYCP3)...
  6. Zhang T, Murphy M, Gearhart M, Bardwell V, Zarkower D. The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis. Development. 2014;141:3662-71 pubmed publisher
    ..differentiation, causing inappropriate expression of spermatogonial differentiation factors, including SOHLH1, SOHLH2 and DMRT1 as well as the meiotic initiation factor STRA8, and causing most late spermatogonia to undergo apoptosis...
  7. Hermann B, Mutoji K, Velte E, Ko D, Oatley J, Geyer C, et al. Transcriptional and translational heterogeneity among neonatal mouse spermatogonia. Biol Reprod. 2015;92:54 pubmed publisher
    ..g., Kit, Sohlh2, Stra8), suggesting additional heterogeneity is introduced at the posttranscriptional level...
  8. Upton H, Hong K, Collins K. Direct single-stranded DNA binding by Teb1 mediates the recruitment of Tetrahymena thermophila telomerase to telomeres. Mol Cell Biol. 2014;34:4200-12 pubmed publisher
    ..of telomere binding by each of the seven Tetrahymena thermophila telomerase holoenzyme proteins TERT, p65, Teb1, p50, p75, p45, and p19...
  9. Kristensen S, Ebbesen P, Andersen C. Transcriptional profiling of five isolated size-matched stages of human preantral follicles. Mol Cell Endocrinol. 2015;401:189-201 pubmed publisher
    ..the most abundant and differentially expressed transcripts and included germ cell transcription factors LHX8 and SOHLH2 which were significantly down-regulated during preantral follicle development...

More Information

Publications30

  1. Valente L, Dehé P, Klutstein M, Aligianni S, Watt S, Bähler J, et al. Myb-domain protein Teb1 controls histone levels and centromere assembly in fission yeast. EMBO J. 2013;32:450-60 pubmed publisher
    ..The essential S. pombe protein Teb1 contains two Myb-like DNA binding domains related to those found in telomere proteins and binds the human telomere ..
  2. Ren Y, Suzuki H, Jagarlamudi K, Golnoski K, McGuire M, Lopes R, et al. Lhx8 regulates primordial follicle activation and postnatal folliculogenesis. BMC Biol. 2015;13:39 pubmed publisher
    ..Previously, we discovered that global knockouts of germ cell-specific transcriptional co-regulators Sohlh1, Sohlh2, Lhx8, and Nobox, cause rapid oocyte loss and ovarian failure...
  3. Zhang G, Sun X, Feng Y, Li B, Li Y, Yang F, et al. Zearalenone exposure impairs ovarian primordial follicle formation via down-regulation of Lhx8 expression in vitro. Toxicol Appl Pharmacol. 2017;317:33-40 pubmed publisher
    ..such as LIM homeobox 8 (Lhx8), newborn ovary homeobox (Nobox), spermatogenesis and oogenesis helix-loop-helix (Sohlh2), and factor in the germline alpha (Figl?) in a dose dependent manner...
  4. Takayama Y, Shirai M, Masuda F. Characterisation of functional domains in fission yeast Ams2 that are required for core histone gene transcription. Sci Rep. 2016;6:38111 pubmed publisher
    ..Moreover, we show that Ams2 interacts with Teb1, which itself binds to the core histone gene promoters...
  5. Jiang J, Chan H, Cash D, Miracco E, Ogorzalek Loo R, Upton H, et al. Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions. Science. 2015;350:aab4070 pubmed publisher
    ..we identify two additional proteins that form a complex (TEB) with single-stranded telomere DNA-binding protein Teb1, paralogous to heterotrimeric replication protein A (RPA)...
  6. Busada J, Niedenberger B, Velte E, Keiper B, Geyer C. Mammalian target of rapamycin complex 1 (mTORC1) Is required for mouse spermatogonial differentiation in vivo. Dev Biol. 2015;407:90-102 pubmed publisher
    ..In addition, rapamycin also blocked the RA-induced translational activation of mRNAs encoding KIT, SOHLH1, and SOHLH2 without affecting expression of STRA8...
  7. Zhao G, Du S, Wang H, Hu X, Deng M, Yu S, et al. First report of zoonotic Cryptosporidium spp., Giardia intestinalis and Enterocytozoon bieneusi in golden takins (Budorcas taxicolor bedfordi). Infect Genet Evol. 2015;34:394-401 pubmed publisher
    ..specimens, with three genotypes known (BEB6, D and I) and four novel internal transcribed spacer (ITS) genotypes (TEB1-TEB4). The present study revealed, for the first time, the presence of zoonotic C. parvum IId A19G1, G...
  8. Kalai Grami L, Karkouch I, Naili O, Slimene I, Elkahoui S, Zekri R, et al. Production and identification of iturin A lipopeptide from Bacillus methyltrophicus TEB1 for control of Phoma tracheiphila. J Basic Microbiol. 2016;56:864-71 pubmed publisher
    A lipopeptide-producing endophytic Bacillus methyltrophicus TEB1 strain exhibited potent antifungal activity against Phoma tracheiphila...
  9. Upton H, Chan H, Feigon J, Collins K. Shared Subunits of Tetrahymena Telomerase Holoenzyme and Replication Protein A Have Different Functions in Different Cellular Complexes. J Biol Chem. 2017;292:217-228 pubmed publisher
    ..of TER, TERT, and eight additional proteins, including the telomeric repeat single-stranded DNA-binding protein Teb1 and its heterotrimer partners Teb2 and Teb3...
  10. Shin Y, Ren Y, Suzuki H, Golnoski K, Ahn H, Mico V, et al. Transcription factors SOHLH1 and SOHLH2 coordinate oocyte differentiation without affecting meiosis I. J Clin Invest. 2017;127:2106-2117 pubmed publisher
    ..we have investigated whether expression of spermatogenesis and oogenesis bHLH transcription factor 1 (Sohlh1) and Sohlh2 coordinates oocyte differentiation within the embryonic ovary...
  11. Suzumori N, Pangas S, Rajkovic A. Candidate genes for premature ovarian failure. Curr Med Chem. 2007;14:353-7 pubmed
    ..factors that regulate oocyte gene expression in animal models and include Nobox, Taf4b, Figla, Lhx8, Sohlh1 and Sohlh2 are likely to be key mediators of fertility in humans...
  12. Zhang H, Zhang X, Ji S, Hao C, Mu Y, Sun J, et al. Sohlh2 inhibits ovarian cancer cell proliferation by upregulation of p21 and downregulation of cyclin D1. Carcinogenesis. 2014;35:1863-71 pubmed publisher
    Spermatogenesis and oogenesis basic helix-loop-helix (bHLH) transcription factor 2 (Sohlh2) functions as a bhlh transcription factor to regulate mouse germ cell differentiation...
  13. Qin Y, Jiao X, Dalgleish R, Vujovic S, Li J, Simpson J, et al. Novel variants in the SOHLH2 gene are implicated in human premature ovarian failure. Fertil Steril. 2014;101:1104-1109.e6 pubmed publisher
    To determine whether variants in the SOHLH2 gene contribute to human premature ovarian failure (POF) in different ethnicities. Case-control genetic study. University hospitals...
  14. Lim E, Choi Y. Transcription factors in the maintenance and survival of primordial follicles. Clin Exp Reprod Med. 2012;39:127-31 pubmed publisher
    ..These transcriptional regulators include: Figla, Lhx8, Nobox, Sohlh1, and Sohlh2. A subset of these transcriptional regulators is mutated in women with ovarian insufficiency and infertility...
  15. Zhang H, Hao C, Wang Y, Ji S, Zhang X, Zhang W, et al. Sohlh2 inhibits human ovarian cancer cell invasion and metastasis by transcriptional inactivation of MMP9. Mol Carcinog. 2016;55:1127-37 pubmed publisher
    ..We previously identified Sohlh2 as an important inhibitor of ovarian cancer cell proliferation...
  16. Song B, Zhang Y, He X, Du W, Ruan J, Zhou F, et al. Association of genetic variants in SOHLH1 and SOHLH2 with non-obstructive azoospermia risk in the Chinese population. Eur J Obstet Gynecol Reprod Biol. 2015;184:48-52 pubmed publisher
    ..specific basic helix-loop-helix 1 (SOHLH1) and spermatogenesis and oogenesis specific basic helix-loop-helix 2 (SOHLH2) play essential roles for both spermatogenesis and oogenesis...
  17. Park M, Lee Y, Jang H, Lee O, Park S, Kim J, et al. SOHLH2 is essential for synaptonemal complex formation during spermatogenesis in early postnatal mouse testes. Sci Rep. 2016;6:20980 pubmed publisher
    Spermatogenesis- and oogenesis-specific helix-loop-helix transcription factor 2 (SOHLH2) is exclusively expressed in germ cells of the gonads. Previous studies show that SOHLH2 is critical for spermatogenesis in mouse...
  18. Ji S, Zhang W, Zhang X, Hao C, Hao A, Gao Q, et al. Sohlh2 suppresses epithelial to mesenchymal transition in breast cancer via downregulation of IL-8. Oncotarget. 2016;7:49411-49424 pubmed publisher
    ..We previously identified sohlh2 is a tumor suppressor in the pathogenesis of ovarian cancer...
  19. Shen L, Kondo Y, Guo Y, Zhang J, Zhang L, Ahmed S, et al. Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet. 2007;3:2023-36 pubmed
    ..We examined seven genes in detail, including ANKRD30A, FLJ40201, INSL6, SOHLH2, FTMT, C12orf12, and DPPA5...
  20. Zhang X, Liu R, Su Z, Zhang Y, Zhang W, Liu X, et al. Immunohistochemical Study of Expression of Sohlh1 and Sohlh2 in Normal Adult Human Tissues. PLoS ONE. 2015;10:e0137431 pubmed publisher
    The expression pattern of Sohlh1 (spermatogenesis and oogenesis specific basic helix-loop-helix 1) and Sohlh2 in mice has been reported in previous studies...
  21. Woloszynska Read A, Zhang W, Yu J, Link P, Mhawech Fauceglia P, Collamat G, et al. Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stage. Clin Cancer Res. 2011;17:2170-80 pubmed publisher
    ..the relationship between expression and methylation of X-linked (MAGE-A1, NY-ESO-1, XAGE-1) and autosomal (BORIS, SOHLH2) CG genes, global DNA methylation (5mdC levels, LINE-1, Alu, and Sat-? methylation), and clinicopathology, using ..