SOCS1

Summary

Gene Symbol: SOCS1
Description: suppressor of cytokine signaling 1
Alias: CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP-3, TIP3, suppressor of cytokine signaling 1, JAK binding protein, STAT induced SH3 protein 1, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, cytokine-inducible SH2 protein 1
Species: human
Products:     SOCS1

Top Publications

  1. Neuwirt H, Puhr M, Santer F, Susani M, Doppler W, Marcias G, et al. Suppressor of cytokine signaling (SOCS)-1 is expressed in human prostate cancer and exerts growth-inhibitory function through down-regulation of cyclins and cyclin-dependent kinases. Am J Pathol. 2009;174:1921-30 pubmed publisher
    ..In summary, we show that SOCS-1 is expressed in prostate cancer both in vitro and in vivo and acts as a negative growth regulator. ..
  2. Ueki K, Kondo T, Kahn C. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol. 2004;24:5434-46 pubmed
    ..These data indicate that SOCS-1 and SOCS-3 act as negative regulators in insulin signaling and serve as one of the missing links between insulin resistance and cytokine signaling. ..
  3. Li Z, Metze D, Nashan D, Muller Tidow C, Serve H, Poremba C, et al. Expression of SOCS-1, suppressor of cytokine signalling-1, in human melanoma. J Invest Dermatol. 2004;123:737-45 pubmed
    ..SOCS-1 is a progression marker of human melanoma and may downregulate biological responses by endogenous and/or therapeutically administered cytokines. ..
  4. Rui L, Yuan M, Frantz D, Shoelson S, White M. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem. 2002;277:42394-8 pubmed
    ..Inflammation induces the expression of SOCS proteins. We show that SOCS1 or SOCS3 targeted IRS1 and IRS2, two critical signaling molecules for insulin action, for ubiquitin-mediated ..
  5. De Sepulveda P, Okkenhaug K, Rose J, Hawley R, Dubreuil P, Rottapel R. Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. EMBO J. 1999;18:904-15 pubmed
    We have identified Socs1 as a downstream component of the Kit receptor tyrosine kinase signalling pathway...
  6. Albanesi C, Federici M, Giustizieri M, Scarponi C, Girolomoni G. Suppressor of cytokine signaling-1 inhibits interferon-gamma-induced activation of human keratinocytes. Ann N Y Acad Sci. 2002;973:79-82 pubmed
  7. Flowers L, Subramaniam P, Johnson H. A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells. Oncogene. 2005;24:2114-20 pubmed
    ..we have characterized a novel tyrosine kinase inhibitor peptide, Tkip, that is a mimetic of suppressor of cytokine signaling 1 (SOCS-1)...
  8. Sasi W, Jiang W, Sharma A, Mokbel K. Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer. BMC Cancer. 2010;10:178 pubmed publisher
    ..In this study, we examined the expression of SOCS1-7 genes in normal and breast cancer tissue and correlated this with several clinico-pathological and prognostic ..
  9. Park Y, Shon S, Kim A, Kim K, Yang Y, Cho D, et al. SOCS1 induced by NDRG2 expression negatively regulates STAT3 activation in breast cancer cells. Biochem Biophys Res Commun. 2007;363:361-7 pubmed
    ..Furthermore, NDRG2 has been found to highly up-regulate the expression level of SOCS1 mRNA and protein...

More Information

Publications72

  1. Pothlichet J, Chignard M, Si Tahar M. Cutting edge: innate immune response triggered by influenza A virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-dependent pathway. J Immunol. 2008;180:2034-8 pubmed
    ..b>SOCS1 to SOCS7, but not cytokine-inducible Src homology 2-containing protein (CIS), are constitutively expressed in ..
  2. Ram P, Waxman D. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J Biol Chem. 1999;274:35553-61 pubmed
  3. Gregorieff A, Pyronnet S, Sonenberg N, Veillette A. Regulation of SOCS-1 expression by translational repression. J Biol Chem. 2000;275:21596-604 pubmed
    ..Moreover, coupled with previous findings, they suggest that SOCS expression is tightly regulated through multiple mechanisms, in order to avoid inappropriate interference with cytokine-mediated effects. ..
  4. He Y, Zhang W, Zhang R, Zhang H, Min W. SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation. J Biol Chem. 2006;281:5559-66 pubmed
    ..In the present study, we have shown that SOCS1, a member of suppressor of cytokine signaling, induces ASK1 degradation...
  5. Melzner I, Weniger M, Bucur A, Brüderlein S, Dorsch K, Hasel C, et al. Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein. Int J Cancer. 2006;118:1941-4 pubmed
    ..Therefore, we conclude that loss of SOCS-1 function either by mutation or by the complete deletion of the gene plays an important role in the dysregulation of JAK/STAT signaling in Karpas1106P and PMBL...
  6. Fernandez Mercado M, Cebrian V, Euba B, García Granero M, Calasanz M, Novo F, et al. Methylation status of SOCS1 and SOCS3 in BCR-ABL negative and JAK2V617F negative chronic myeloproliferative neoplasms. Leuk Res. 2008;32:1638-40 pubmed publisher
  7. Huang F, Steeg P, Price J, Chiu W, Chou P, Xie K, et al. Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis. Cancer Res. 2008;68:9634-42 pubmed publisher
  8. Evans M, Yu C, Lohani A, Mahdi R, Liu X, Trzeciak A, et al. Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals. Oncogene. 2007;26:1941-8 pubmed
    ..SOCS genes in breast, ovarian, squamous cell and hepatocellular carcinoma has led to speculation that silencing of SOCS1 and SOCS3 genes might promote oncogenic transformation of epithelial tissues...
  9. Zhang J, Li H, Yu J, Wang S, Ren X. Role of SOCS1 in tumor progression and therapeutic application. Int J Cancer. 2012;130:1971-80 pubmed publisher
    b>SOCS1, a prototype molecule of the SOCS family, was initially defined as a suppressor of cytokine signaling...
  10. Chim C, Fung T, Cheung W, Liang R, Kwong Y. SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway. Blood. 2004;103:4630-5 pubmed
    b>SOCS1 and SHP1 negatively regulate the Janus kinase/signal transducer and activator of transcription (Jak/STAT) signaling pathway...
  11. Kamio M, Yoshida T, Ogata H, Douchi T, Nagata Y, Inoue M, et al. SOCS1 [corrected] inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein. Oncogene. 2004;23:3107-15 pubmed
    ..Suppressor of cytokine signaling-1 (SOCS1)/JAB, a suppressor of cytokine signaling, is known to be induced by IFNgamma, and functions as an antioncogene ..
  12. Sutherland K, Lindeman G, Choong D, Wittlin S, Brentzell L, Phillips W, et al. Differential hypermethylation of SOCS genes in ovarian and breast carcinomas. Oncogene. 2004;23:7726-33 pubmed
    ..We have investigated whether silencing or inactivation of SOCS genes occurs in ovarian and breast carcinomas. The SOCS1 and SOCS2 CpG islands were found to be hypermethylated in 23 and 14% of primary ovarian cancers, respectively, ..
  13. Yoshimura A, Ohkubo T, Kiguchi T, Jenkins N, Gilbert D, Copeland N, et al. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 1995;14:2816-26 pubmed
    ..Thus CIS appears to be a unique regulatory molecule for cytokine signal transduction. ..
  14. Mansell A, Smith R, Doyle S, Gray P, Fenner J, Crack P, et al. Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol. 2006;7:148-55 pubmed
    ..The transient activation of Mal and subsequent SOCS-1-mediated degradation is a rapid and selective means of limiting primary innate immune response. ..
  15. Baetz A, Koelsche C, Strebovsky J, Heeg K, Dalpke A. Identification of a nuclear localization signal in suppressor of cytokine signaling 1. FASEB J. 2008;22:4296-305 pubmed publisher
    ..In addition, SOCS1 has been identified to regulate stability of nuclear NF-kappaB subunits...
  16. Yadav A, Fitzgerald P, Sajadi M, Gilliam B, Lafferty M, Redfield R, et al. Increased expression of suppressor of cytokine signaling-1 (SOCS-1): A mechanism for dysregulated T helper-1 responses in HIV-1 disease. Virology. 2009;385:126-33 pubmed publisher
    ..These results suggest a link between high levels of SOCS-1, defects in innate immunity and adaptive Th1 responses that may be reflected in the loss of Th1 immune competence observed with AIDS patients. ..
  17. Hashimoto K, Ishibashi K, Ishioka K, Zhao D, Sato M, Ohara S, et al. RSV replication is attenuated by counteracting expression of the suppressor of cytokine signaling (SOCS) molecules. Virology. 2009;391:162-70 pubmed publisher
    ..RSV infection up-regulated SOCS1, SOCS3, and CIS mRNA expression in HEp-2 cells...
  18. Koelsche C, Strebovsky J, Baetz A, Dalpke A. Structural and functional analysis of a nuclear localization signal in SOCS1. Mol Immunol. 2009;46:2474-80 pubmed publisher
    b>Suppressor of cytokine signaling 1 (SOCS1) belongs to a family of genes involved in inducible feedback inhibition of janus kinases (JAKs) and signal transducers and activators of transcription (STATs) signaling pathway...
  19. Strebovsky J, Walker P, Lang R, Dalpke A. Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus. FASEB J. 2011;25:863-74 pubmed publisher
    ..Previously the authors surprisingly observed that SOCS1 translocated into the nucleus, which was because of the presence of a nuclear localization sequence...
  20. Starr R, Willson T, Viney E, Murray L, Rayner J, Jenkins B, et al. A family of cytokine-inducible inhibitors of signalling. Nature. 1997;387:917-21 pubmed
    ..Transcription of all four SOCS genes is increased rapidly in response to interleukin-6, in vitro and in vivo, suggesting they may act in a classic negative feedback loop to regulate cytokine signal transduction. ..
  21. Jiang S, Zhang H, Lu M, He X, Li Y, Gu H, et al. MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. Cancer Res. 2010;70:3119-27 pubmed publisher
    ..Here, we report that the tumor suppressor gene suppressor of cytokine signaling 1 (socs1) is an evolutionarily conserved target of miR-155 in breast cancer cells...
  22. Sporri B, Kovanen P, Sasaki A, Yoshimura A, Leonard W. JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling. Blood. 2001;97:221-6 pubmed
    JAB/suppressor of cytokine signaling 1 (SOCS1) STAT-induced STAT inhibitor-1 (SSI-1) (JAB/SOCS1/SSI-1) is an SH2-domain-containing protein that is induced by and negatively regulates signaling by a number of cytokines including ..
  23. Soriano S, Hernanz Falcón P, Rodríguez Frade J, De Ana A, Garzón R, Carvalho Pinto C, et al. Functional inactivation of CXC chemokine receptor 4-mediated responses through SOCS3 up-regulation. J Exp Med. 2002;196:311-21 pubmed
    ..The data provide clear evidence for signaling cross-talk between cytokine and chemokine responses in building a functional immune system. ..
  24. Piganis R, de Weerd N, Gould J, Schindler C, Mansell A, Nicholson S, et al. Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2. J Biol Chem. 2011;286:33811-8 pubmed publisher
    ..Here we have investigated the mechanism by which suppressor of cytokine signaling 1 (SOCS1) inhibits type I IFN signaling...
  25. Nagai H, Naka T, Terada Y, Komazaki T, Yabe A, Jin E, et al. Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas. J Hum Genet. 2003;48:65-9 pubmed
    We recently demonstrated inactivation in hepatocellular carcinomas (HCCs) of the gene encoding SOCS1/JAB1/SSI-1, a JAK-binding protein that regulates the JAK/STAT signal-transduction pathway...
  26. Ryo A, Suizu F, Yoshida Y, Perrem K, Liou Y, Wulf G, et al. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell. 2003;12:1413-26 pubmed
    ..These findings uncover two important mechanisms of regulating NF-kappaB signaling and offer new insight into the pathogenesis and treatment of some human diseases such as cancers. ..
  27. Ko E, Kim S, Joh J, Park C, Park J, Kim D. CpG island hypermethylation of SOCS-1 gene is inversely associated with HBV infection in hepatocellular carcinoma. Cancer Lett. 2008;271:240-50 pubmed publisher
    ..No prognostic effect of SOCS-1 methylation was observed in the HCCs. In conclusion, the present study suggests that SOCS-1 methylation in HCC may be negatively associated with HB(s)Ag status. ..
  28. Starska K, Forma E, Lewy Trenda I, Stasikowska O, Brys M, Krajewska W, et al. The expression of SOCS1 and TLR4-NFkappaB pathway molecules in neoplastic cells as potential biomarker for the aggressive tumor phenotype in laryngeal carcinoma. Folia Histochem Cytobiol. 2009;47:401-10 pubmed publisher
    b>Suppressor of cytokine signaling 1 (SOCS1) is the key regulator of cytokine-mediated innate and adaptive immunity. One of the molecular mechanisms of SOCS1 is connected with inhibition of TLR4-NFkappaB pathway...
  29. Madonna S, Scarponi C, De Pita O, Albanesi C. Suppressor of cytokine signaling 1 inhibits IFN-gamma inflammatory signaling in human keratinocytes by sustaining ERK1/2 activation. FASEB J. 2008;22:3287-97 pubmed publisher
    ..Here we show that, after IFN-gamma stimulation, SOCS1 inhibited IFN-gamma receptor and STAT1 phosphorylation but maintained ERK1/2 activation...
  30. Ryo A, Tsurutani N, Ohba K, Kimura R, Komano J, Nishi M, et al. SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag. Proc Natl Acad Sci U S A. 2008;105:294-9 pubmed publisher
    ..Here, we report that the suppressor of cytokine signaling 1 (SOCS1) is an inducible host factor during HIV-1 infection and regulates the late stages of the HIV-..
  31. Jost E, do O N, Dahl E, Maintz C, Jousten P, Habets L, et al. Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders. Leukemia. 2007;21:505-10 pubmed
  32. Ali S, Nouhi Z, Chughtai N, Ali S. SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor. J Biol Chem. 2003;278:52021-31 pubmed
    ..Together our results provide a novel function for SHP-2 as a positive regulator of cytokine receptor signaling by regulating ubiquitination/degradation pathways. ..
  33. Oshimo Y, Kuraoka K, Nakayama H, Kitadai Y, Yoshida K, Chayama K, et al. Epigenetic inactivation of SOCS-1 by CpG island hypermethylation in human gastric carcinoma. Int J Cancer. 2004;112:1003-9 pubmed
    ..013 and 0.002, respectively). Our results suggest that transcriptional inactivation of the SOCS-1 gene by hypermethylation may be involved in development, progression and metastasis of GC. ..
  34. Vuong B, Arenzana T, Showalter B, Losman J, Chen X, Mostecki J, et al. SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome. Mol Cell Biol. 2004;24:9092-101 pubmed
    ..These data link SOCS-1 directly with the proteasome pathway and suggest another function for the SH2 domain of SOCS-1 in the regulation of Jak/STAT signaling. ..
  35. Dai X, Sayama K, Yamasaki K, Tohyama M, Shirakata Y, Hanakawa Y, et al. SOCS1-negative feedback of STAT1 activation is a key pathway in the dsRNA-induced innate immune response of human keratinocytes. J Invest Dermatol. 2006;126:1574-81 pubmed
    ..We infected cells with the dominant-negative forms of STAT1 (STAT1F), STAT3 (STAT3F), and SOCS1 using adenovirus vectors...
  36. Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, et al. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 1999;18:1309-20 pubmed
    ..We have recently identified a JAK-binding protein (JAB) that inhibits JAK signaling in cells...
  37. Fukushima N, Sato N, Sahin F, Su G, Hruban R, Goggins M. Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms. Br J Cancer. 2003;89:338-43 pubmed
    ..These results indicate that loss of SOCS-1 gene is associated with transcriptional silencing and may have growth-promoting effects, and that its methylation is a useful marker of pancreatic cancer. ..
  38. Marine J, Topham D, McKay C, Wang D, Parganas E, Stravopodis D, et al. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell. 1999;98:609-16 pubmed
    b>SOCS1 is an SH2-containing protein that is primarily expressed in thymocytes in a cytokine- and T cell receptor-independent manner. SOCS1 deletion causes perinatal lethality with death by 2-3 weeks...
  39. De Sepulveda P, Ilangumaran S, Rottapel R. Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation. J Biol Chem. 2000;275:14005-8 pubmed
    Suppressor of cytokine signaling-1 (SOCS1) is an inducible Src homology 2 (SH2)-containing protein that negatively regulates cytokine and growth factor signaling required during thymic development...
  40. Komazaki T, Nagai H, Emi M, Terada Y, Yabe A, Jin E, et al. Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers. Jpn J Clin Oncol. 2004;34:191-4 pubmed
    SOCS-1, a JAK-binding protein (SSI-1/SOCS-1/JAB), regulates the JAK/STAT signal transduction pathway that relays signals from various cytokines in the extracellular matrix into the cell...
  41. Miller R, Schlaepfer E, Baenziger S, Crameri R, Zeller S, Byland R, et al. HIV interferes with SOCS-1 and -3 expression levels driving immune activation. Eur J Immunol. 2011;41:1058-69 pubmed publisher
    ..We speculate that regulating SOCS may be a potential way to counteract immune activation in HIV disease. ..
  42. Rottapel R, Ilangumaran S, Neale C, La Rose J, Ho J, Nguyen M, et al. The tumor suppressor activity of SOCS-1. Oncogene. 2002;21:4351-62 pubmed
    ..These data suggest that loss-of-function of SOCS-1 may collaborate with a variety of hematopoietic oncogenes to facilitate tumor progression. ..
  43. Mottok A, Renne C, Seifert M, Oppermann E, Bechstein W, Hansmann M, et al. Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities. Blood. 2009;114:4503-6 pubmed publisher
    ..In primary mediastinal large B-cell lymphoma and Hodgkin lymphoma (HL), inactivating mutations in SOCS1, an inhibitor of JAK/STAT signaling, contribute to deregulated STAT activity...
  44. Calabrese V, Mallette F, Deschênes Simard X, Ramanathan S, Gagnon J, Moores A, et al. SOCS1 links cytokine signaling to p53 and senescence. Mol Cell. 2009;36:754-67 pubmed publisher
    b>SOCS1 is lost in many human tumors, but its tumor suppression activities are not well understood...
  45. Lesinski G, Zimmerer J, Kreiner M, Trefry J, Bill M, Young G, et al. Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells. BMC Cancer. 2010;10:142 pubmed publisher
    ..Basal and interferon-alpha (IFN-alpha) or interferon-gamma (IFN-gamma)-induced expression of SOCS1 and SOCS3 proteins was evaluated by immunoblot analysis in a panel of n = 10 metastatic human melanoma cell lines, ..
  46. Weniger M, Melzner I, Menz C, Wegener S, Bucur A, Dorsch K, et al. Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation. Oncogene. 2006;25:2679-84 pubmed
    ..01). Collectively, these findings support the concept that PMBL and cHL share many overlapping features, and that defective tumor suppressor gene SOCS-1 triggers an oncogenic pathway operative in both lymphomas. ..
  47. Krebs D, Hilton D. SOCS proteins: negative regulators of cytokine signaling. Stem Cells. 2001;19:378-87 pubmed
    ..magnitude and duration, and it is now clear that the suppressor of cytokine signaling (SOCS) family of proteins (SOCS1-SOCS7 and CIS) contributes significantly to this process...
  48. Egwuagu C, Yu C, Zhang M, Mahdi R, Kim S, Gery I. Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. J Immunol. 2002;168:3181-7 pubmed
    ..We show here that CD4(+) naive T cells constitutively express low levels of SOCS1, SOCS2, and SOCS3 mRNAs...
  49. Galm O, Yoshikawa H, Esteller M, Osieka R, Herman J. SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood. 2003;101:2784-8 pubmed
    ..SOCS-1 (also known as JAB and SSI-1) inhibits signaling by many cytokines...
  50. Federici M, Giustizieri M, Scarponi C, Girolomoni G, Albanesi C. Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1. J Immunol. 2002;169:434-42 pubmed
    ..We show in this work that SOCS1, SOCS2, SOCS3, and cytokine-inducible SH2-containing protein mRNA were up-regulated by IFN-gamma in normal human ..
  51. Zhang J, Farley A, Nicholson S, Willson T, Zugaro L, Simpson R, et al. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci U S A. 1999;96:2071-6 pubmed
    ..Analogous to the family of F-box-containing proteins, it appears that the SOCS proteins may act as adaptor molecules that target activated cell signaling proteins to the protein degradation pathway. ..
  52. Chu P, Yeh C, Hsu N, Chang Y, Chang J, Yeh K. Epigenetic alteration of the SOCS1 gene in hepatocellular carcinoma. Swiss Med Wkly. 2010;140:w13065 pubmed publisher
    ..The purpose of this study was to investigate the expression of SOCS1 gene in HCC and explore the potential molecular mechanisms...
  53. Mahller Y, Sakthivel B, Baird W, Aronow B, Hsu Y, Cripe T, et al. Molecular analysis of human cancer cells infected by an oncolytic HSV-1 reveals multiple upregulated cellular genes and a role for SOCS1 in virus replication. Cancer Gene Ther. 2008;15:733-41 pubmed publisher
    ..highlighted nodes for AP-1 subunits and interferon signaling via STAT1, suppressor of cytokine signaling-1 (SOCS1), SOCS3 and RANTES...
  54. Russell R, Sufan R, Zhou B, Heir P, Bunda S, Sybingco S, et al. Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Nat Med. 2011;17:845-53 pubmed publisher
    ..Here we show that VHL directly binds suppressor of cytokine signaling 1 (SOCS1) to form a heterodimeric E3 ligase that targets phosphorylated JAK2 (pJAK2) for ubiquitin-..
  55. Ungureanu D, Saharinen P, Junttila I, Hilton D, Silvennoinen O. Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol Cell Biol. 2002;22:3316-26 pubmed
  56. Nishi M, Ryo A, Tsurutani N, Ohba K, Sawasaki T, Morishita R, et al. Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag. FEBS Lett. 2009;583:1243-50 pubmed publisher
    b>Suppressor of cytokine signaling 1 (SOCS1) is a recently identified host factor that positively regulates the intracellular trafficking and stability of HIV-1 Gag...
  57. Chen X, Losman J, Cowan S, Donahue E, Fay S, Vuong B, et al. Pim serine/threonine kinases regulate the stability of Socs-1 protein. Proc Natl Acad Sci U S A. 2002;99:2175-80 pubmed
    ..These data suggest that the Pim kinases may regulate cytokine-induced JAK-STAT signaling through modulation of Socs-1 protein levels. ..
  58. Qiao X, He B, Chiu A, Knowles D, Chadburn A, Cerutti A. Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells. Nat Immunol. 2006;7:302-10 pubmed
    ..Thus, human immunodeficiency virus 1 may evade protective T cell-dependent IgG and IgA responses by 'hijacking' physiological feedback inhibitors in B cells via Nef. ..
  59. Fourouclas N, Li J, Gilby D, Campbell P, Beer P, Boyd E, et al. Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders. Haematologica. 2008;93:1635-44 pubmed publisher
    ..Mutation or methylation of other components of JAK/STAT signaling, such as the negative regulators suppressor of cytokine signaling 1 (SOCS1) and SOCS3, may contribute to the pathogenesis of both JAK2 V617F positive and negative ..
  60. Chen C, Tsay W, Tang J, Shen H, Lin S, Huang S, et al. SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia. Genes Chromosomes Cancer. 2003;37:300-5 pubmed
    ..The suppressor of cytokine signaling-1 (SOCS1) down-regulates Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway activity and ..
  61. Endo T, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature. 1997;387:921-4 pubmed
    ..Using the yeast two-hybrid system, we have now isolated a new SH2-domain-containing protein, JAB, which is a JAK-binding protein that interacts with the Jak2 tyrosine-kinase JH1 domain...
  62. Masood K, Rottenberg M, Carow B, Rao N, Ashraf M, Hussain R, et al. SOCS1 gene expression is increased in severe pulmonary tuberculosis. Scand J Immunol. 2012;76:398-404 pubmed publisher
    ..Interferon-gamma (IFN-?), SOCS1 and SOCS3 gene expression was determined by RT-PCR. Statistical analysis was performed using the Mann-Whitney test...
  63. Pezet A, Favre H, Kelly P, Edery M. Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling. J Biol Chem. 1999;274:24497-502 pubmed
    ..We thus propose that the early expressed SOCS genes (SOCS-1 and SOCS-3) switch off PRL signaling and that the later expressed SOCS-2 gene can restore the sensitivity of cells to PRL, partly by suppressing the SOCS-1 inhibitory effect. ..