SOAT1

Summary

Gene Symbol: SOAT1
Description: sterol O-acyltransferase 1
Alias: ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT, acyl-coenzyme A:cholesterol acyltransferase 1, sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
Species: human

Top Publications

  1. ncbi Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis
    L L Rudel
    Arteriosclerosis Research Program, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Lipidol 12:121-7. 2001
  2. ncbi Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT)
    Jennifer A Locke
    Department of Urologic Sciences, University of British Columbia, The Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada
    Prostate 68:20-33. 2008
  3. ncbi ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization
    S Cases
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141, USA
    J Biol Chem 273:26755-64. 1998
  4. pmc Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues
    N Sakashita
    Second Department of Pathology, Kumamoto University School of Medicine, Kumamoto, Japan
    Am J Pathol 156:227-36. 2000
  5. ncbi Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains
    S Lin
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 274:23276-85. 1999
  6. ncbi Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells
    C C Chang
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755
    J Biol Chem 268:20747-55. 1993
  7. ncbi Human acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes
    B L Li
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 274:11060-71. 1999
  8. ncbi The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain
    Zhan Yun Guo
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    J Biol Chem 280:37814-26. 2005
  9. pmc Knockdown of ACAT-1 reduces amyloidogenic processing of APP
    Henri J Huttunen
    Neurobiology of Disease Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States
    FEBS Lett 581:1688-92. 2007
  10. ncbi Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease
    M A Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Mol Psychiatry 8:635-8. 2003

Detail Information

Publications436 found, 100 shown here

  1. ncbi Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis
    L L Rudel
    Arteriosclerosis Research Program, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Lipidol 12:121-7. 2001
    ..responsible for cholesterol ester formation in tissues, acyl coenzyme A:cholesterol acyltransferase types 1 and 2 (ACAT1 and ACAT2)...
  2. ncbi Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT)
    Jennifer A Locke
    Department of Urologic Sciences, University of British Columbia, The Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada
    Prostate 68:20-33. 2008
    ..The objective of this work was to determine the effect of an androgen agonist, R1881, on intracellular cholesterol synthesis and esterification in androgen-sensitive (AS) prostate cancer (LNCaP) cells...
  3. ncbi ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization
    S Cases
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141, USA
    J Biol Chem 273:26755-64. 1998
    ..Mouse tissue expression studies and the disruption of the mouse ACAT gene (Acact) have indicated that more than one ACAT exists in mammals and specifically that another enzyme is important in ..
  4. pmc Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues
    N Sakashita
    Second Department of Pathology, Kumamoto University School of Medicine, Kumamoto, Japan
    Am J Pathol 156:227-36. 2000
    To investigate the distribution of acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) in various human tissues, we examined tissues of autopsy cases immunohistochemically...
  5. ncbi Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains
    S Lin
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 274:23276-85. 1999
    Acyl-CoA:cholesterol acyltransferase (ACAT) plays important roles in cellular cholesterol homeostasis and is involved in atherosclerosis. ACAT-1 protein is located mainly in the ER...
  6. ncbi Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells
    C C Chang
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755
    J Biol Chem 268:20747-55. 1993
    ..element in forming cholesterol ester from cholesterol is the enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT). ACAT is a membrane protein located in the endoplasmic reticulum...
  7. ncbi Human acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes
    B L Li
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 274:11060-71. 1999
    Acyl-CoA:cholesterol acyltransferase (ACAT) plays important roles in cellular cholesterol homeostasis. Four human ACAT-1 mRNAs (7.0, 4.3, 3.6, and 2...
  8. ncbi The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain
    Zhan Yun Guo
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    J Biol Chem 280:37814-26. 2005
    ..within the region of amino acids 354-493, expressed these mutants in Chinese hamster ovary cells lacking ACAT1, and prepared microsomes from transfected cells...
  9. pmc Knockdown of ACAT-1 reduces amyloidogenic processing of APP
    Henri J Huttunen
    Neurobiology of Disease Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States
    FEBS Lett 581:1688-92. 2007
    Previous studies have shown that acyl-coenzyme A:cholesterol acyl transferase (ACAT), an enzyme that controls cellular equilibrium between free cholesterol and cholesteryl esters, modulates proteolytic processing of APP in cell-based and ..
  10. ncbi Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease
    M A Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Mol Psychiatry 8:635-8. 2003
    A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P=0...
  11. ncbi Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes
    P Oelkers
    Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 273:26765-71. 1998
    The enzyme acyl coenzyme A:cholesterol acyltransferase 1 (ACAT1) mediates sterol esterification, a crucial component of intracellular lipid homeostasis...
  12. ncbi Association between acyl-coenzyme A: cholesterol acyltransferase gene and risk for Alzheimer's disease in Chinese
    Fa Guo Zhao
    Department of Neurology, First Hospital of Peking University, Beijing, China
    Neurosci Lett 388:17-20. 2005
    ..Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1), an endoplasmic-reticulum-resident enzyme that catalyses the formation of cholesteryl esters (CEs) from ..
  13. ncbi [Treatment of cardiac insufficiency: does treatment depend on whether its cause is ischemic or idiopathic?]
    M Galinier
    Service de cardiologie clinique et expérimentale, Centre hospitalo universitaire de Toulouse Rangueil
    Arch Mal Coeur Vaiss 92:727-32. 1999
    ..of patients with non-ischaemic cardiomyopathy, contrasting with the absence of an effect with this molecule in the STAT-CHF trial which only comprised 29% of patients with non-ischaemic cardiomyopathy...
  14. ncbi Toxicologic effects of a novel acyl-CoA:cholesterol acyltransferase inhibitor in cynomolgus monkeys
    J F Reindel
    Department of Pathology, Parke Davis Pharmaceutical Research, Division of Warner Lambert Company, Ann Arbor, Michigan 48105
    Toxicol Pathol 22:510-8. 1994
    PD 132301-2, an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, was administered orally to cynomolgus monkeys for 2 wk at doses of 25, 50, 100, and 200 mg/kg to assess potential subacute toxicity...
  15. ncbi [Specific treatment of the acute cerebral infarct. Present and future]
    J J Muñoz-Torrero
    Servicio de Neurologia, Unidad de Ictus, Hospital Universitario La Paz, Universidad Autonoma de Madrid, Madrid, Espana
    Rev Neurol 31:959-82. 2000
    ..Regarding Ancrod, a recent North American study (STAT) with administration of it within three hours showed significant benefit three months later...
  16. ncbi [Cardiac insufficiency: prevention of ventricular arrhythmias]
    P Mabo
    , CHU, Rennes
    Arch Mal Coeur Vaiss 93:23-8. 2000
    ..have not been demonstrated, especially in view of the discordance between the results of the GESICA and CHF STAT trials...
  17. ncbi Mucosal acidification and an acid microclimate in the hen colon in vitro
    G Laverty
    School of Life and Health Sciences, University of Delaware, Newark 19716
    J Comp Physiol B 163:633-41. 1994
    ..Titration measurements of the mucosal acidification rate (pH-stat technique) averaged 1.63 +/- 0.25 microEq.cm-2.h-1...
  18. ncbi Protective effects of prostaglandins in the isolated gastric mucosa of the eel, Anguilla anguilla
    C Faggio
    Istituto di Fisiologia Generale, , Salita Sperone, Sant Agata, Italy
    J Comp Physiol B 170:357-63. 2000
    ..PGE2) on acid secretion rate (J(H)) and on alkaline secretion rate (J(OH)) were evaluated (with the aid of the pH stat method) in isolated gastric mucosa mounted in Ussing chambers...
  19. pmc Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells
    Courtney R Plumlee
    Department of Laboratory Medicine, University of Washington, Seattle, USA
    Virol J 2:89. 2005
    ..To model the molecular mechanisms behind this phenotype, we characterized the effects of ethanol on Jak-Stat and MAPK pathways in Huh7 human hepatoma cells, in HCV replicon cell lines, and in primary human hepatocytes...
  20. ncbi Members of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway are present and active in human sperm
    O J D'Cruz
    Department of Reproductive Biology, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Fertil Steril 76:258-66. 2001
    To investigate whether components of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway are present and active in human sperm.
  21. pmc The effects of sterol structure upon sterol esterification
    Don S Lin
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Atherosclerosis 208:155-60. 2010
    Cholesterol is esterified in mammals by two enzymes: LCAT (lecithin cholesterol acyltransferase) in plasma and ACAT(1) and ACAT(2) (acyl-CoA cholesterol acyltransferases) in the tissues...
  22. ncbi Up-regulation of acyl-coenzyme A:cholesterol acyltransferase (ACAT) in nephrotic syndrome
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, Irvine, California, USA
    Kidney Int 61:1769-75. 2002
    ..is inhibited and Ch-7alpha is augmented by intracellular free cholesterol, which is avidly esterified by acyl-CoA:cholesterol acyltransferase (ACAT). Therefore, we hypothesized that NS may result in up-regulation of hepatic ACAT.
  23. ncbi Leukemia inhibitory factor and NGF regulate signal transducers and activators of transcription activation in sympathetic ganglia: convergence of cytokine- and neurotrophin-signaling pathways
    P Rajan
    Molecular Neurobiology Laboratory, Massachusetts General Hospital, Boston 02114, USA
    Brain Res 802:198-204. 1998
    ..leukemia inhibitory factor (LIF)-dependent activation of signal transducers and activators of transcription (STAT) factors...
  24. pmc Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events
    Leticia Quintanilla-Martinez
    Institutes of Pathology, GSF National Research Center for Health and Environment, Neuherberg, Germany
    Am J Pathol 162:1449-61. 2003
    ..Recently, it was proposed that constitutively activated Stat 3 (Stat 3 phosphorylated) contributes to the pathogenesis of multiple myeloma (MM) by preventing apoptosis and ..
  25. ncbi Bladder tumor markers: need, nature and application. 2. Tumor and tumor-associated antigens
    M M Kirollos
    Urology Department, Torbay Hospital, South Devon Health Care Trust, UK
    Int Urogynecol J Pelvic Floor Dysfunct 9:228-35. 1998
    ..These are currently the Bard BTA, BTA Stat and Aura-Tek FDP tests...
  26. ncbi A community-based evaluation of the Vita-Stat automatic blood pressure recorder
    K Salaita
    Department of Epidemiology, Johns Hopkins University School of Public Health and Hygiene, Baltimore, Maryland
    Am J Hypertens 3:366-72. 1990
    A random sample of ten community-based Vita-Stat automatic blood pressure recorders (ABPR) was evaluated for accuracy and repeatability...
  27. ncbi Phlebotomine sandflies (Diptera: Psychodidae) of Tamil Nadu and Pondicherry, southern India, in relation to visceral leishmaniasis
    K Ilango
    Zoological Survey of India, Southern Regional Station, Madras
    Ann Trop Med Parasitol 88:413-31. 1994
    ..A new species, Sergentomyia shettyi sp. nov., is described and Sergentomyia babu and Sergentomyia insularis stat. nov. are considered distinct species on the basis of their parapatric distribution. Phlebotomus papatasi and P...
  28. ncbi Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro
    P J Uelmen
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 270:26192-201. 1995
    Acyl-coenzyme A:cholesterol acyltransferase (ACAT) catalyzes the esterification of cholesterol with long chain fatty acids and is believed to play an important part in the development of atherosclerotic lesions...
  29. ncbi Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1
    Yan Ru Su
    Atherosclerosis Research Unit, Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tenn 37232 6300, USA
    Circulation 111:2373-81. 2005
    Macrophage acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) and apolipoprotein E (apoE) have been implicated in regulating cellular cholesterol homeostasis and therefore play critical roles in foam cell formation...
  30. doi Repression of Wasp by JAK/STAT signalling inhibits medial actomyosin network assembly and apical cell constriction in intercalating epithelial cells
    Claire Bertet
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Development 136:4199-212. 2009
    ..We report that apical constriction is repressed by JAK/STAT signalling in the lateral ectoderm independently of Twist...
  31. ncbi Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain
    D C van der Plas
    Department of Hematology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Leukemia 10:1317-25. 1996
    ..Activation of the JAK/STAT pathway has been implicated in IL-7R signaling...
  32. ncbi NMP 22, BTA stat test and cytology in the diagnosis of bladder cancer: a comparative study
    J L Gutierrez Banos
    Department of Urology, Marques de Valdecilla University Hospital, Santander, Spain
    Urol Int 66:185-90. 2001
    To evaluate the usefulness of the NMP 22 and BTA stat test in the diagnosis and follow-up of bladder cancer and to compare these tests to cytology and cystoscopy, routine diagnostic methods.
  33. ncbi STAT proteins mediate angiotensin II-induced production of TIMP-1 in human proximal tubular epithelial cells
    XiangMei Chen
    Department of Nephrology, Chinese General Hospital of PLA, Beijing, China
    Kidney Int 64:459-67. 2003
    ..Angiotensin II has been reported to activate signal transducers and activators of transcription (STAT) and induce proliferation of myocyte and vascular smooth muscle cells (VSMC)...
  34. ncbi The optional long 5'-untranslated region of human ACAT1 mRNAs impairs the production of ACAT1 protein by promoting its mRNA decay
    Xiaonan Zhao
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Acta Biochim Biophys Sin (Shanghai) 41:30-41. 2009
    We have previously reported that human ACAT1 mRNAs produce the 50 kDa protein using the AUG(11397-1399) initiation codon, and also a minor 56 kDa isoform using the upstream in-frame GGC(1274-1276) initiation codon...
  35. ncbi Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6)
    Joachim Geyer
    Institute of Pharmacology and Toxicology, Justus Liebig University of Giessen, Frankfurter Strasse 107, 35392 Giessen, Germany
    J Biol Chem 282:19728-41. 2007
    We have cloned human sodium-dependent organic anion transporter (SOAT) cDNA, which consists of 1502 bp and encodes a 377-amino acid protein...
  36. doi Quasi steady state growth of Lactococcus lactis in glucose-limited acceleration stat (A-stat) cultures
    Kaarel Adamberg
    Department of Food Processing, Tallinn University of Technology, Ehitajate tee 5, Tallinn, Estonia
    Antonie Van Leeuwenhoek 95:219-26. 2009
    Quasi steady state growth of Lactococcus lactis IL 1403 was studied in glucose-limited A-stat cultivation experiments with acceleration rates (a) from 0.003 to 0.06 h(-2) after initial stabilization of the cultures in chemostat at D = 0...
  37. ncbi Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome
    N D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, USA
    Circulation 110:419-25. 2004
    ..Acyl-coenzyme A:cholesterol acyltransferase (ACAT) catalyzes intracellular esterification of cholesterol and plays an important role in production of apolipoprotein ..
  38. ncbi Effect of ACAT inhibition on the progression of coronary atherosclerosis
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 354:1253-63. 2006
    The enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) esterifies cholesterol in a variety of tissues. In some animal models, ACAT inhibitors have antiatherosclerotic effects.
  39. doi ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: the CAPTIVATE randomized trial
    Marijn C Meuwese
    Department of Vascular Medicine, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    JAMA 301:1131-9. 2009
    Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT), an intracellular enzyme involved in cholesterol accumulation, with pactimibe was developed to assist in the prevention of cardiovascular disease.
  40. pmc Purification of recombinant acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) from H293 cells and binding studies between the enzyme and substrates using difference intrinsic fluorescence spectroscopy
    Catherine C Y Chang
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, United States
    Biochemistry 49:9957-63. 2010
    Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is a membrane-bound enzyme utilizing long-chain fatty acyl-coenzyme A and cholesterol to form cholesteryl esters and coenzyme A...
  41. ncbi Effects of pH management during selective antegrade cerebral perfusion on cerebral microcirculation and metabolism: alpha-stat versus pH-stat
    Sebastian Dahlbacka
    Department of Surgery, Clinical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
    Ann Thorac Surg 84:847-55. 2007
    ..Selective cerebral perfusion (SCP) is used for extending the period during which surgical procedures can be safely performed. We sought to determine the direct effects of pH management on cerebral microcirculation and metabolism during SCP...
  42. ncbi Inhibition of adrenergic proton extrusion in rainbow trout red cells by nitrite-induced methaemoglobinaemia
    M Nikinmaa
    Department of Zoology, University of Helsinki, Finland
    J Comp Physiol B 162:424-9. 1992
    ..methaemoglobinaemia on adrenergic proton extrusion from rainbow trout red blood cells were studied using the pH-stat method...
  43. ncbi Effects of the acyl coenzyme A:cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions
    Jean Claude Tardif
    Montreal Heart Institute, 5000 Belanger St, Montreal, H1T 1C8, Canada
    Circulation 110:3372-7. 2004
    Inhibition of the acyl coenzyme A:cholesterol acyltransferase (ACAT) enzyme may prevent excess accumulation of cholesteryl esters in macrophages. The ACAT inhibitor avasimibe was shown to reduce experimental atherosclerosis...
  44. ncbi Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I
    Don Fleenor
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Horm Res 66:101-10. 2006
    ..of GHR and PRLR mRNAs in 3T3-L1 preadipocytes during the course of adipocyte differentiation; (b) the induction of STAT-5 activity by GH and PRL during adipogenesis; and (c) the acute effects of GH and PRL on the suppressors of ..
  45. ncbi Lack of toxic effects of F 12511, a novel potent inhibitor of acyl-coenzyme A: cholesterol O-acyltransferase, on human adrenocortical cells in culture
    D Junquero
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Castres Cedex, France
    Biochem Pharmacol 61:387-98. 2001
    Inhibition of acyl-coenzyme A: cholesterol O-acyltransferase (EC 2.3.1.26; ACAT) reduces intracellular cholesteryl esters that are substrates for steroidogenesis in adrenal cells...
  46. ncbi [Ghrelin down-regulates ACAT-1 in THP-1 derived foam cells via growth hormone secretagogue receptor-dependent pathway]
    Jing jing Wan
    Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:1030-4. 2009
    To investigate the effects of Ghrelin on the expression of acyl coenzyme A:cholesterol acyltransferases-1 (ACAT-1) in THP-1 derived foam cells.
  47. ncbi Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis
    Mari A Nowell
    Medical Biochemistry and Immunology, Tenovus Building, School of Medicine, Heath Park Campus, Cardiff University, Cardiff CF14 4XN, UK
    Arthritis Rheum 54:2084-95. 2006
    ..To determine whether interleukin-6 (IL-6) trans-signaling directs the expression of pre-B cell colony-enhancing factor (PBEF) in vitro and in vivo...
  48. ncbi Receptor-mediated tobacco toxicity: cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of alpha7 nicotinic receptor in oral keratinocytes
    Juan Arredondo
    Department of Dermatology, University of California Davis, Sacramento, CA, USA
    FASEB J 20:2093-101. 2006
    ..chain reaction (PCR) and In-cell Western, the KCs stimulated with ADSS or nicotine showed multifold increases of STAT-3. These effects could be completely blocked or significantly (P<0...
  49. ncbi Bladder tumor markers for monitoring recurrence and screening comparison of hyaluronic acid-hyaluronidase and BTA-Stat tests
    Vinata B Lokeshwar
    Department of Urology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Cancer 95:61-72. 2002
    ..The authors examined the efficacy of the hyaluronic acid-hyaluronidase (HA-HAase) and BTA-Stat tests to detect and predict bladder carcinoma recurrence and tested their specificity for bladder carcinoma ..
  50. ncbi Routine follow-up cystoscopy in detection of recurrence in patients being monitored for bladder cancer
    M P Raitanen
    Department of Urology, Tampere University Hospital, Finland
    Ann Chir Gynaecol 90:261-5. 2001
    ..Therefore, new tumour markers have been developed. BTA stat has been reported to have high sensitivity in detecting both primary and recurrent bladder tumours, and may have ..
  51. ncbi Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia
    H Yagyu
    Departments of Metabolic Diseases, Ophthalmology, Pathology, Faculty of Medicine, University of Tokyo, Hongo, Tokyo 113 8655, Japan
    J Biol Chem 275:21324-30. 2000
    Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes esterification of cellular cholesterol. To investigate the role of ACAT-1 in atherosclerosis, we have generated ACAT-1 null (ACAT-1-/-) mice...
  52. ncbi Brain cooling efficiency with pH-stat and alpha-stat cardiopulmonary bypass in newborn pigs
    C D Kurth
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, PA 19104, USA
    Circulation 96:II-358-63. 1997
    ..surgery, recent studies suggest improved neurological outcome after deep hypothermic circulatory arrest when pH-stat cardiopulmonary bypass is used compared with alpha-stat cardiopulmonary bypass...
  53. ncbi Activation of signal transducers and activators of transcription 1 and 3 by leukemia inhibitory factor, oncostatin-M, and interferon-gamma in adipocytes
    J M Stephens
    Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    J Biol Chem 273:31408-16. 1998
    ..IFNgamma is shown to be a potent activator of STAT 1 as indicated by both tyrosine phosphorylation and nuclear translocation...
  54. ncbi Using STAT properly
    William Wesp
    University of Minnesota Medical Center, Fairview, Minneapolis, USA
    Radiol Manage 28:26-30; quiz 31-3. 2006
    The misuse of the term STAT has long been a problem in many hospitals. Instead of being the universal word for "immediate," it has become a convenient phrase used, in some cases, to get what the physician wants now...
  55. ncbi Novel effects of the acyl-coenzyme A:Cholesterol acyltransferase inhibitor 58-035 on foam cell development in primary human monocyte-derived macrophages
    A Rodriguez
    Department of Medicine, Sinai Hospital of Baltimore, MD 21215
    Arterioscler Thromb Vasc Biol 19:2199-206. 1999
    We examined the effect of acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitors on intracellular cholesterol stores in primary human monocyte-derived macrophages (HMMs) during foam cell formation...
  56. ncbi Roles for the interleukin-4 receptor and associated JAK/STAT proteins in human articular chondrocyte mechanotransduction
    S J Millward-Sadler
    Osteoarticular Research Group, Division of Pathology, University of Edinburgh, Medical School, Edinburgh, EH8 9AG, UK
    Osteoarthritis Cartilage 14:991-1001. 2006
    ..IL4) receptor (IL4R) subtypes and associated Janus kinase/signal transducers and activators of transcription (JAK/STAT) molecules in human articular chondrocytes and assess the role of JAK/STAT proteins in chondrocyte ..
  57. ncbi Evaluation of the i-STAT point-of-care analyzer in critically ill adult patients
    Jacoline Steinfelder-Visscher
    Department of Extra Corporeal Circulation, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Extra Corpor Technol 40:57-60. 2008
    ..We therefore evaluated the analytical performance of the i-STAT point-of-care analyzer in two critically ill adult patient populations...
  58. ncbi The effect of inhibition of acyl coenzyme A-cholesterol acyltransferase (ACAT) on exercise performance in patients with peripheral arterial disease
    William R Hiatt
    Section of Vascular Medicine, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Vasc Med 9:271-7. 2004
    This study tested the hypothesis that avasimibe, an inhibitor of acyl coenzyme A-cholesterol acyltransferase (ACAT), would improve treadmill exercise performance in patients with claudication secondary to peripheral arterial disease (PAD)...
  59. ncbi Functionality of the seventh and eighth transmembrane domains of acyl-coenzyme A:cholesterol acyltransferase 1
    Zhan Yun Guo
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Biochemistry 46:10063-71. 2007
    Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is a resident enzyme in the endoplasmic reticulum. ACAT1 is a homotetrameric protein and contains nine transmembrane domains (TMDs)...
  60. doi Inhibition of Janus kinase 2 and signal transduction and activator of transcription 3 protect against cecal ligation and puncture-induced multiple organ damage and mortality
    Liu Hui
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to Chinese PLA General Hospital formerly 304th Hospital, Beijing 100037, People s Republic of China
    J Trauma 66:859-65. 2009
    Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway plays an important role in sepsis, transducing a multitude of inflammatory signals. To date, knowledge of JAK/STAT pathway in sepsis is limited...
  61. doi Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: an implication for the pathogenesis of arthritis
    Sang Heng Kok
    School fo Dentistry, College of Medicine, National Taiwan University, and National Taiwan University Hospital, Taipei, Taiwan
    Arthritis Rheum 60:1451-62. 2009
    ..To examine the roles of STATs 1 and 3 in CCL2 production in human osteoblastic cells and their influences on arthritis development...
  62. ncbi [Chlamydia pneumoniae induces THP-1-derived foam cell formation by up-regulating the expression of acyl-coenzyme A: cholesterol acyltransferase 1]
    Ping He
    Department of Gerontology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:430-5. 2009
    To investigate the expression changes of acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) on Chlamydia pneumoniae (C.pn) induced foam cell formation.
  63. ncbi Effect of intravesical instillations on the human complement factor H related protein (BTA stat) test
    M P Raitanen
    Division of Urology, Tampere University Hospital, Tampere, Finland
    Eur Urol 40:422-6. 2001
    The BTA stat is a rapid, non-invasive, qualitative urine test that detects bladder tumor-associated antigen (human complement factor H related protein) in urine...
  64. doi Chlamydia pneumoniae induces macrophage-derived foam cell formation by up-regulating acyl-coenzyme A: cholesterol acyltransferase 1
    Ping He
    Department of Gerontology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jie Fang Avenue, Wuhan 430022, Hubei Province, China
    Microbes Infect 11:157-63. 2009
    ..In macrophages, the accumulation of cholesteryl esters synthesized by acyl-coenzyme A: cholesterol acyltransferase 1(ACAT1) plays a crucial role in foam cell formation, a hallmark of early atherosclerotic lesions...
  65. ncbi Specificity of transcription enhancement via the STAT responsive element in the serine protease inhibitor 2.1 promoter
    T J Wood
    Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Mol Cell Endocrinol 130:69-81. 1997
    ..to the gamma-interferon activated sequence (GAS) family of signal transducer and activator of transcription (STAT) response elements. We have investigated the STAT and cytokine specificity of the SPI 2...
  66. ncbi Comparison of pH-stat and alpha-stat cardiopulmonary bypass on cerebral oxygenation and blood flow in relation to hypothermic circulatory arrest in piglets
    C D Kurth
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine 19104, USA
    Anesthesiology 89:110-8. 1998
    ..Recent work has suggested improved neurologic recovery after deep hypothermic arrest with pH-stat cardiopulmonary bypass (CPB) compared with alpha-stat CPB...
  67. ncbi Molecular cloning, functional expression and tissue distribution of rat acyl-coenzyme A:cholesterol acyltransferase
    H Matsuda
    Department of Biochemistry, Kumamoto University School of Medicine, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Biochim Biophys Acta 1391:193-203. 1998
    Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an enzyme catalyzing the intracellular formation of cholesteryl esters from free cholesterol and fatty acyl-CoA...
  68. ncbi Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cells
    T Seo
    Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, 630W 168th Street PH1512, New York, New York 10032, USA
    Biochemistry 40:4756-62. 2001
    ..Two ACAT genes have been identified; ACAT1 is expressed ubiquitously while ACAT2 is primarily expressed in intestine and liver...
  69. ncbi Discovery and combinatorial synthesis of fungal metabolites beauveriolides, novel antiatherosclerotic agents
    Hiroshi Tomoda
    School of Pharmacy, Kitasato University, Shirokane, Minato ku, Tokyo 108 8641, Japan
    Acc Chem Res 41:32-9. 2008
    ..There are two ACAT isozymes in mammals, ACAT1 and ACAT2...
  70. ncbi Nutritional status of the population in Dalmatia, Croatia
    N Smolej-Narancic
    Institute for Anthropological Research, Zagreb, Croatia
    Coll Antropol 23:59-68. 1999
    ..Elucidation of these effects will provide information on the adequacy of NHANES data for the assessment of nutritional stat+us in Dalmatian population.
  71. pmc Emergency medicine and the laboratory
    E Hardin
    Department of Emergency Medicine, King Drew Medical Center, Los Angeles, CA 90059, USA
    J Natl Med Assoc 88:279-82. 1996
    ..Special consideration is given to the requirements for a stat laboratory, which provides mandatory service for any large general hospital emergency department...
  72. pmc Intracellular signalling pathways activated by leptin
    Gema Fruhbeck
    Department of Endocrinology, Clinica Universitaria de Navarra and Metabolic Research Laboratory, University of Navarra, 36 Avda Pío XII, 31008 Pamplona, Spain
    Biochem J 393:7-20. 2006
    ..The full-length isoform, OB-Rb, contains intracellular motifs required for activation of the JAK/STAT signal transduction pathway, and is considered to be the functional receptor...
  73. ncbi Sensitization of IL-2 signaling through TLR-7 enhances B lymphoma cell immunogenicity
    Jelena Tomic
    Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women s College Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    J Immunol 176:3830-9. 2006
    ..their expression of B7-family members, production of TNF-alpha and IL-10, and levels of tyrosine-phosphorylated STAT-1 and STAT-3 proteins. S28690 increased CD25 expression on CLL cells and sensitized them to IL-2 signaling...
  74. pmc Human airway eosinophils exhibit preferential reduction in STAT signaling capacity and increased CISH expression
    Mandy E Burnham
    Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53792, USA
    J Immunol 191:2900-6. 2013
    ..whereas other IL-5 family induced endpoints remain functional, we tested the hypothesis that EOS(A) possess a JAK/STAT-specific regulatory mechanism (because JAK/STAT signaling is critical to EOS survival)...
  75. ncbi Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains
    Masako Tanabe
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
    Biochem Biophys Res Commun 311:39-48. 2003
    ..The ISRE, a recently reported site for IFN-beta induction, but not STAT binding site, located around -30bp of TLR3 promoter responded to MV to induce TLR3 expression...
  76. ncbi Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation
    Yulan Qing
    Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 280:1849-53. 2005
    ..cytoplasmic tyrosine residues, and Tyr(419) is required for signal transducer and activator of transcription (STAT) 1 activation in mouse embryo fibroblasts...
  77. pmc Bioactive compounds or metabolites from black raspberries modulate T lymphocyte proliferation, myeloid cell differentiation and Jak/STAT signaling
    Thomas A Mace
    Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, 302B Comprehensive Cancer Center, 400 W 12th Ave, Columbus, OH, 43210, USA
    Cancer Immunol Immunother 63:889-900. 2014
    ..Furthermore, specific BRB components and their metabolites may be a source of lead compounds for drug development that exhibits targeted immunological outcomes or inhibition of specific STAT-regulated signaling pathways.
  78. ncbi New method for the determination of the half inhibition concentration (IC50) of cholinesterase inhibitors
    Markéta Kovárová
    Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic
    Z Naturforsch C 68:133-8. 2013
    ..The method has been validated for twelve different types of cholinesterase inhibitors. The determined IC50 values are comparable to those obtained by independent, more complicated, and expensive methods (Ellman's and pH-stat).
  79. ncbi Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophages
    Yuchang Fu
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294 3360, USA
    Atherosclerosis 188:102-11. 2006
    ..Moreover, we determined that the expression of acyl-coenzyme A: cholesterol-acyltransferase 1 (ACAT1) gene was up-regulated by the overexpression of ALBP gene, and on the other hand, the ATP-binding cassette A1 (..
  80. ncbi Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Nat Med 10:168-74. 2004
    The transcription factor, signal transducer and activator of transcription-3 (STAT-3) contributes to various physiological processes...
  81. ncbi Equilibrium dynamics of the Dean-Kawasaki equation: mode-coupling theory and its extension
    Bongsoo Kim
    Department of Physics and Institute for Soft and Bio Matter Science, Changwon National University, Changwon 641 773, Korea
    Phys Rev E Stat Nonlin Soft Matter Phys 89:012150. 2014
    ..b>Stat. Mech. (2008) P02004]...
  82. pmc Differential cortical neurotrophin and cytogenetic adaptation after voluntary exercise in normal and amnestic rats
    J M Hall
    Behavioral Neuroscience Program, Department of Psychology, Binghamton University State University of New York, United States
    Neuroscience 258:131-46. 2014
    ..Following 2-weeks of VEx or stationary housing conditions (Stat), rats were behaviorally tested and brains were harvested either the day after VEx (24-h) or after an additional 2-..
  83. ncbi Uteroglobin suppresses SCCA gene expression associated with allergic asthma
    Rabindranath Ray
    Section on Developmental Genetics, Heritable Disorders Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 280:9761-4. 2005
    ..that treatment of cultured human bronchial epithelial cells with IL-4 or IL-13 stimulates phosphorylation of STAT-1 and STAT-6 leading to SCCA-1 (SERPINB3) and SCCA-2 (SERPINB4) gene expression...
  84. ncbi Prolactin potentiates insulin-stimulated leptin expression and release from differentiated brown adipocytes
    S Viengchareun
    INSERM U478, Institut Fédératif de Recherche Claude Bernard, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75018 Paris, France
    J Mol Endocrinol 33:679-91. 2004
    ..Addition of PRL leads to activation of the JAK/STAT and MAP kinase signaling pathways, demonstrating that PRLRs are functional in these cells...
  85. ncbi Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells
    Andrea Baetz
    Institute of Medical Microbiology and Hygiene, Philipps University Marburg, 35037 Marburg, Germany
    J Biol Chem 279:54708-15. 2004
    ..constitute a class of negative regulators for Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathways...
  86. doi The feasibility and impact of midnight routine blood draws on laboratory orders and processing time
    Atsushi Sorita
    From the Departments of Medicine
    Am J Clin Pathol 141:805-10. 2014
    To evaluate the feasibility of midnight routine blood draws and assess their impact on test result availability and stat laboratory orders.
  87. doi Role of renin-angiotensin system in activation of macrophages by modified lipoproteins
    Naimeh Rafatian
    Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Am J Physiol Heart Circ Physiol 305:H1309-20. 2013
    ..exposed to ac-LDL and decreased scavenger receptor A (SR-A) and acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT-1) protein levels...
  88. pmc Mutational spectrum of adult T-ALL
    Martin Neumann
    Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Department of Hematology and Oncology, Berlin, Germany
    Oncotarget 6:2754-66. 2015
    ..A frequently affected pathway was the JAK/STAT pathway (18%) and a significant proportion of T-ALL patients harboured mutations in epigenetic regulators (33%), ..
  89. pmc Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation
    Jan Jacob Schuringa
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Exp Med 200:623-35. 2004
    Activation of the transcription factor signal transducer and activator of transcription (STAT)5 is involved in various aspects of hematopoiesis, affecting cell proliferation, differentiation, and cell survival...
  90. ncbi 15-Deoxy-delta12,14-prostaglandin J2 regulates leukemia inhibitory factor signaling through JAK-STAT pathway in mouse embryonic stem cells
    Johnson Rajasingh
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Exp Cell Res 312:2538-46. 2006
    ..These results suggest that PPARgamma agonists regulate LIF signaling through JAK-STAT pathway leading to growth and self-renewal of ES cells.
  91. doi Role of JAK/STAT signaling in neuroepithelial stem cell maintenance and proliferation in the Drosophila optic lobe
    Wei Wang
    School of Life Sciences, Tsinghua University, Beijing 100084, China
    Biochem Biophys Res Commun 410:714-20. 2011
    ..The JAK/STAT pathway plays pleiotropic roles in Drosophila development and in the larval brain, has been shown to inhibit ..
  92. doi Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells
    Ching Ming Chien
    Faculty of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC
    Chem Biol Interact 176:40-7. 2008
    ..One STAT family member, STAT5, is often constitutively active in myeloid leukaemia...
  93. ncbi Small molecular inhibitors of p-STAT3: novel agents for treatment of primary and metastatic CNS cancers
    Amy B Heimberger
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Recent Pat CNS Drug Discov 3:179-88. 2008
    ..A key transcriptional factor, signal transducer and activator of transcription (STAT) 3, drives the fundamental components of tumor malignancy and metastases in the CNS...
  94. pmc A novel requirement for Janus kinases as mediators of drug resistance induced by fibroblast growth factor-2 in human cancer cells
    Catarina R Carmo
    Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
    PLoS ONE 6:e19861. 2011
    ..These effects are independent of activation of signal transducer and activator of transcription (STAT) 1, STAT3 and STAT5A/B, the normal targets of JAK signaling...
  95. doi Basal, endogenous leptin is metabolically active in newborn rat pups
    Latifa Abdennebi-Najar
    UPSP EGEAL Institut Polytechnique LaSalle de Beauvais, 19 rue Pierre Waguet, Beauvais Cedex, France
    J Matern Fetal Neonatal Med 24:1486-91. 2011
    The adipocyte-derived hormone leptin regulates food intake and body weight via the activation of JAK-STAT pathway in mammalian adult hypothalamic neurons...
  96. doi Multiplexed evaluation of a cell-based assay for the detection of antidrug neutralizing antibodies to panitumumab in human serum using automated fluorescent microscopy
    Jason Pennucci
    Clinical Immunology Department, Amgen Inc, Thousand Oaks, CA 91320, USA
    J Biomol Screen 15:644-52. 2010
    ..reader was used for the measurement of tyrosine phosphorylation of the epidermal growth factor receptor (EGFR) and STAT-1 redistribution between the cytoplasm and nucleus in the human epidermoid carcinoma cell line A431...
  97. doi Enzymatic hydrolysis of cuttlefish (Sepia officinalis) and sardine (Sardina pilchardus) viscera using commercial proteases: effects on lipid distribution and amino acid composition
    Emna Soufi Kechaou
    Universite de Nantes, GEPEA UMR CNRS 6144, BP 406, 44602 Saint Nazaire, France
    J Biosci Bioeng 107:158-64. 2009
    ..Enzymatic hydrolyses were performed using the three proteases Protamex, Alcalase, and Flavourzyme by the pH-stat method (24 h, pH 8, 50 degrees C)...
  98. pmc Interleukin-7 promotes the survival of human CD4+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway
    Nizar Chetoui
    Centre de Recherche en Rhumatologie Immunologie, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, and Faculté de Médecine, Universite Laval, Quebec, PQ, Canada
    Immunology 130:418-26. 2010
    ..Interleukin-7-induced activation of the janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway is sufficient for cell survival and up-regulation of Bcl-2 proteins...
  99. pmc Suppressors of cytokine signaling abrogate diabetic nephropathy
    Guadalupe Ortiz-Muñoz
    Renal and Vascular Research Laboratory, Fundacion Jimenez Diaz, Autonoma University, Madrid, Spain
    J Am Soc Nephrol 21:763-72. 2010
    Activation of Janus kinase/signal transducers and activators of transcription (JAK/STAT) is an important mechanism by which hyperglycemia contributes to renal damage, suggesting that modulation of this pathway may prevent renal and ..
  100. doi Jagged1 regulates the activation of astrocytes via modulation of NFkappaB and JAK/STAT/SOCS pathways
    Eleonora Morga
    Laboratoire de Neurobiologie, Life Sciences, Université du Luxembourg, Luxembourg, 1511 Luxembourg
    Glia 57:1741-53. 2009
    ..The inhibition of Jagged1 induced a modulation of the JAK/STAT/SOCS signaling pathway...
  101. pmc Differential regulation of STAT family members by glycogen synthase kinase-3
    Eleonore Beurel
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama, Birmingham, Alabama 35294 0017, USA
    J Biol Chem 283:21934-44. 2008
    ..The signal transducer and activator of transcription (STAT) family of transcription factors has a central role in inflammatory reactions, being stimulated by multiple ..

Research Grants74

  1. Mechanism of CREB dysregulation in Alzheimer brain
    Subbiah Pugazhenthi; Fiscal Year: 2013
    ..ii) Inflammation activates c-jun, STAT-1 and NF-?B, the transcriptions factors that compete with CREB for the limited pool of coactivators, CBP and p300...
  2. Osteopontin regulates ubiquitin-proteasome degradation of STAT1
    Paul C Kuo; Fiscal Year: 2012
    ..models of LPS- and cecal ligation and puncture (CLP) mediated sepsis, our studies show that: 1) OPN acts with STAT-interacting LIM (SLIM) protein to ubiquitinate (Ub) an essential iNOS transcription factor, STAT1, for 26s ..
  3. STAT Activation: Inactivation Cycle and Activated STAT3 in Cancer Cells
    James E Darnell; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The STAT proteins are latent cytoplasmic transcription factors that are activated by tyrosine phosphorylation through cytokine and growth factor interaction with their specific cell surface receptors...
  4. Mechanisms for depleting tumor immunity in AIDS
    CHARLES DAVID PAUZA; Fiscal Year: 2012
    ..transcription factor and increases after stimulation by common [unreadable] chain cytokines, possibly reflecting STAT 5 activation that would free Runx1 for nuclear translocation...
  5. Targeting the JAK/STAT-3 Pathway Signaling Axis in Glioma
    Etty N Benveniste; Fiscal Year: 2013
    ..GBMs show elevated levels and persistent activation of Signal Transducer and Activator of Transcription-3 (STAT-3), a transcription factor that drives expression of genes that regulate anti-apoptotic responses, angiogenesis, ..
  6. Regulation of IL-6-Type Cytokine Cardioprotective Signaling in the Ischemic Heart
    George W Booz; Fiscal Year: 2012
    Activation of JAK-STAT signaling is a common feature of preconditioning and agents that are cardioprotective, including the IL-6-type cytokines. However, mechanisms regulating IL-6 cytokine signaling in the heart are largely unexplored...
  7. TRADD as a Regulator of Cytokine Signaling in Glia
    ETTY BENVENISTE; Fiscal Year: 2009
    ..IFN-y uses Signal Transducer and Activator of Transcription-la (STAT-la) for signal transduction, while the Tumor Necrosis Factor Receptor 1 (TNFRl)-associated death domain (TRADD) ..
  8. SOCS: Its Regulation and Role in Oncogenesis
    Chao Lan Yu; Fiscal Year: 2010
    ..signaling (SOCS)- genes, SOCS1 and SOCS3, are critical targets of signal transducer and activator of transcription (STAT) pathways, providing normal negative feed-back control of signaling by cytokines and growth factors...
  9. INTEGRATION OF CYTOKINE RECEPTORS AND IMMUNORECEPTORS SIGNALING PATHWAYS
    Ruslan Medzhitov; Fiscal Year: 2010
    ..of signal integration between ITAM-containing receptor complexes and cytokine receptors that signal through the Jak-STAT pathways. ITAM-containing receptors play prominent role in all aspects of leukocyte function...
  10. Role of The Jak-Stat Pathway in Ischemic Preconditioning
    Yu Ting Xuan; Fiscal Year: 2010
    ..This proposal will provide important new insights into the signaling and molecular mechanisms whereby the late phase of ischemic PC reprograms the heart in the intact animal. ..
  11. The regulation and activation of STATs in adipocytes
    Jacqueline M Stephens; Fiscal Year: 2013
    ..Our efforts have focused on two STAT proteins, STAT5A and STAT 5B, whose expression is induced during adipogenesis...
  12. Acetylation-Dependent IFN Signal Transduction
    Y Eugene Chin; Fiscal Year: 2010
    ..IFN activated STAT proteins also form homo- or hetero-dimer that bind to sis-inducible element (SIE) to regulate gene expression...
  13. UBP43 in Hematopoiesis
    Dong Er Zhang; Fiscal Year: 2012
    ..bacterial infections and genotoxic insults, by interacting with critical factors in hematopoiesis and in the JAK-STAT signaling pathway and by regulating the level of protein ISGylation...
  14. Tumor Progression of Nuclear EGFR in Breast Cancer
    Mien Chie Hung; Fiscal Year: 2013
    ..we demonstrated that EGFR interacts with STAT3 in the nucleus and the EGFR/STAT3 complex recognizes the ATRS and STAT binding sequence of the iNOS promoter and co-regulates the transcription of the iNOS gene...
  15. Regulation of Cell Signaling by Human Biliverdin Reductase
    Mahin D Maines; Fiscal Year: 2013
    ..Gene array analysis suggested increases in EGFR and hBVR are linked;EGF is the regulator of STAT/JAK signaling...
  16. MicroRNA Modulation of Immune Function in Multiple Sclerosis
    Caroline C Whitacre; Fiscal Year: 2012
    ..We propose to extend our findings to IFN2 treatment of MS patients, since both IFN3 and IFN2 signal through the STAT pathway...
  17. Trim32 Regulation of Piasy in Skin Homeostasis
    Molly F Kulesz-Martin; Fiscal Year: 2013
    ..Trim32 negatively regulates the pro-apoptotic Piasy protein, a repressor of NF-kB, STAT, and SMAD transcription factors that have been implicated in the pathogenesis of psoriasis...
  18. Elucidation of the transcriptional network underlying the Th17 lineage program
    Dan Littman; Fiscal Year: 2013
    ..These include Stat-3, IRF-4, Ahr, BATF, Runx1/CBFK , c-Maf, and RORa...
  19. Mechanism of CD40 signaling to APP metabolism
    Michael J Mullan; Fiscal Year: 2013
    ..We will therefore investigate the role of protein tyrosine kinase and JAK/STAT signaling pathways (some of which are TRAF- independent) in the mediation of both tau phosphorylation and APP ..
  20. Nanoscale analysis of proteomic response to novel targeted therapies for lymphoma
    ALICE CHEN FAN; Fiscal Year: 2013
    ..Finally, I have used NIA together with flow cytometry (FACS) to identify changes in RAS/MAPK/STAT signaling in cells from patients with low grade NHL treated on a clinical trial of single agent atorvastatin...
  21. Role of Angiogenic CXC Chemokines in Intramembranous Bone Repair
    Dean T Yamaguchi; Fiscal Year: 2013
    ..Downstream CXCR2 signaling involving signal transducer and activator of transcription-3 (STAT-3), phosphoinositide 3-kinase (PI3K), and MAPK will be assessed as above in addition to utilizing small molecule ..
  22. Signaling pathways regulated by GSK3 in hematopoietic stem cell
    Jian Huang; Fiscal Year: 2012
    ..Wnt signaling and a downstream target of hematopoietic growth factor signaling pathways that signal through Jak/Stat and PI3 kinase/Akt dependent pathways, has been implicated in the regulation of HSC activity...
  23. Interferon actions and autoimmune disorders
    Michael David; Fiscal Year: 2010
    ..The STAT transcription factors have been identified as an important part of the IFNo/p induced signaling cascade...
  24. Systemic Inflammation and Central Nervous System Dysfunction
    Laura L Dugan; Fiscal Year: 2013
    ..IL-6 activates a host of inflammatory actions through classical Jak/STAT pathway, but we recently found that IL-6, acting through non-cannonical activation of the transcription factor, ..
  25. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2013
    ..PPAR1), 2) Decreases the expression of p21waf1 and 3) Enhances Signal Transducer and Activator of Transcription 3 (STAT-3) phosphorylation despite lower IL-6 levels through decreasing Suppressor of Cytokine Signaling (SOCS)-3 ..
  26. Cytokine-induced epigenetic changes during chronic lung disease
    STEVEN LYNN KUNKEL; Fiscal Year: 2013
    ..dependent pulmonary inflammation using conditional knockout mouse models, and 3) To assess the cytokine-induced JAK-STAT signal transduction pathways that control MLL and JMJD3 expression and influence the subsequent immune response...
  27. ecSOD derived peroxide in pulmonary adaptation to hypoxia
    Michael S Wolin; Fiscal Year: 2013
    ..arteries, signaling studies related to PKG and processes influencing the redox regulation src kinase-mediated STAT-3 phosphorylation promoting expression of miR-204, a master gene regulatory system controlling the development and ..
  28. Stat4 Immunobiology
    Mark H Kaplan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Signal Transducer and Activator of Transcription (STAT) proteins are a family of transcription factors essential for the function of growth factor and cytokine signaling pathways...
  29. Regulation of cyclin D3 in B lymphocyte development
    Marcus R Clark; Fiscal Year: 2013
    ..Specifically, we demonstrate that Igk transcription is controlled by competition between E2A and STAT 5 at the intronic Igk enhancer (Eki)...
  30. The Activation of ERBB3 Signaling as a Resistance Mechanism to Targeted Therapies
    Jeffrey A Engelman; Fiscal Year: 2013
    ..and either EGFR or HER2 controls critical growth and survival signaling pathways including PI3K/AKT, MAPK, and STAT. Previously, we and others observed that all cancer cells addicted to EGFR or HER2, are unique in that PI3K is ..
  31. INSULIN SIGNALING DEFECTS IN PCOS
    Ricardo Azziz; Fiscal Year: 2010
    ..We also found alterations in the expression of components of JAK/STAT and MAPK pathways in PCOS adipose tissue...
  32. Stat4 Immunobiology
    Mark Kaplan; Fiscal Year: 2009
    PROJECT SUMMARY - STAT4 IMMUNOBIOLOGY Signal Transducer and Activator of Transcription (STAT) proteins are a family of transcription factors essential for the function of growth factor and cytokine signaling pathways...
  33. Signaling pathways regulated by GSK3 in hematopoietic stem cell
    Jian Huang; Fiscal Year: 2013
    ..Wnt signaling and a downstream target of hematopoietic growth factor signaling pathways that signal through Jak/Stat and PI3 kinase/Akt dependent pathways, has been implicated in the regulation of HSC activity...
  34. Molecular Basis for Small Molecule STAT3 Inhibition
    Julie S Barber-Rotenberg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Signal transducers and activators of transcription (STAT) proteins function as both cytokines and transcription factors...
  35. Staphylococcus aureus Activation of TNF Signaling Pathways
    Alice S Prince; Fiscal Year: 2013
    ..through its Xr domain, activates the type I interferon cascade, inducing epithelial production of IFN-b and Jak-STAT phosphorylation in a TLR4/TRIF-dependent fashion...
  36. Hepatitis C Virus and Hepatocellular Carcinoma
    Srikanta Dash; Fiscal Year: 2013
    ..response and down regulates the expression of interferon alpha-receptor 1 (IFNAR1) leading to a defective Jak-Stat signaling, reduced phosphorylation /nuclear translocation of Stat1, Stat2 and impaired antiviral response. (iii)...
  37. PREVENTION AND TREATMENT OF IMPOTENCE
    Tom F Lue; Fiscal Year: 2013
    ..In addition, we have identified that among the signaling pathways, Jak/STAT pathway seems to be the main one associated with BDNF enhanced neurite growth...
  38. TYROSINE PHOSPHORYLATION AND GROWTH HORMONE SIGNALING
    Stuart J Frank; Fiscal Year: 2013
    ..tyrosine kinase, JAK2, and signaling molecules including signal transducer and activator of transcription (STAT)-5...
  39. Elucidation of cystatin B associated signaling pathways to reduce HIV reservoirs
    Linda E Rivera; Fiscal Year: 2013
    ..Cystatin B expression is positively correlated with HIV replication and decreased levels STAT-1 phosphorylation (STAT-1PY) in monocyte-derived macrophages (MDM)...
  40. Transcriptional signalling by vitamin A
    Noa Noy; Fiscal Year: 2013
    ..to its function as a vitamin A transporter, STRA6 is a ligand-activated cell surface receptor which activates a JAK/STAT pathway in response to binding retinol-RBP...
  41. Soluble EPO Receptor and EPO Resistance in Dialysis
    Ravi Thadhani; Fiscal Year: 2012
    ..data suggesting that sEpoR inhibits erythropoietin mediated signal transducer and activator of transcription 5 (Stat-5) phosphorylation in cell lines expressing EpoR...
  42. STAT3 in T helper cell development
    Mark H Kaplan; Fiscal Year: 2013
    ..stimulated by the cytokine microenvironment and the activation of Signal Transducer and Activator of Transcription (STAT) proteins that initiate specific genetic programs...
  43. JAK2_STAT3 as a therapeutic target and marker of graft-versus-host disease
    Brian C Betts; Fiscal Year: 2013
    ..Mechanistic studies will evaluate secondary effects on Treg suppression, STAT signaling, and skewing of T helper subsets and related functions...
  44. Development and Applications of Photoinducible Bioorthogonal Chemistry
    Qing Lin; Fiscal Year: 2013
    ..4) To apply the tetrazole-based bioorthogonal chemistry to mimic STAT-1 tyrosine phosphorylation by incorporating a tetrazole amino acid at the tyrosine phosphorylation site (Tyr-701) ..
  45. The Role of HIV Tat-induced SOCS3 in HIV Associated Dementia
    Lisa Nowoslawski; Fiscal Year: 2010
    ..IFN0 signaling will be examined in vitro, in primary human and murine cells, at the level of STAT phosphorylation, target gene induction, and inhibition of HIV replication...
  46. INTERLEUKIN 4 REGULATION OF LYMPHOCYTES
    Mark R Boothby; Fiscal Year: 2010
    ..A unifying theme of these discoveries is that Stat transcription factor induction and the primary structural basis of IL-4R? function are different in the activated T ..
  47. Regulation of Stem Cell Self-renewal and Differentiation
    Margaret T Fuller; Fiscal Year: 2013
    ..We showed that a cytokine like signal from the somatic hub activates the transcription factor STAT in GSCs and their partner somatic cyst stem cells (CySCs) and that activated STAT is critical for maintenance of ..
  48. Role of STAT3 in the pathogenesis of Inflammatory Bowel Disease
    Prema Robinson; Fiscal Year: 2013
    ..Importantly, there is no cure for IBD. Signal transducer and activator of transcription (Stat) 3 ha been shown to play a pathogenic role in mice models of IBD...
  49. Role of the Interleukin12/STAT4 Pathway in Insulin Resistance and Atherosclerosis
    Jerry L Nadler; Fiscal Year: 2013
    ..The central hypothesis is that IL-12/Stat-4 pathway plays a critical role in the induction of IR in visceral and peri-aortic adipose tissue and this will ..
  50. Blood brain barrier immune compromise in NeuroAIDS
    Georgette D Kanmogne; Fiscal Year: 2012
    ..the effects of HIV-1 and viral-induced cytokines on the endothelial cytoskeleton, and decipher the role of STAT-1 on these alterations...
  51. Maternal pro-inflammatory status in obesity regulates placental function
    Theresa L Powell; Fiscal Year: 2013
    ..The role of key intracellular signaling molecules, such as STAT 3, will be investigated employing siRNA approaches in cultured human primary trophoblast cells, and we will examine ..
  52. Cytokine Signaling as a Mediator of Fear and Anxiety After Myocardial Infarction
    NATALIE CELIA TRONSON; Fiscal Year: 2012
    ..Finally, I hypothesize that cytokine-dependent JAK/STAT signaling mediates emotional and mnemonic dysregulation after MI...
  53. Thyroid Epithelial Cell Hyperplasia: Mechanisms of Induction
    HELEN B MULLEN; Fiscal Year: 2012
    ..These studies will use gene knockout, i.e. IFN-/-, IFN-/- SCID, STAT-6-/-, and transgenic NOD.H-2h4 mice expressing TGF or dominant negative TGFRII on thyrocytes or T cells...
  54. Cytokine Signaling as a Mediator of Fear and Anxiety After Myocardial Infarction
    NATALIE CELIA TRONSON; Fiscal Year: 2013
    ..Finally, I hypothesize that cytokine-dependent JAK/STAT signaling mediates emotional and mnemonic dysregulation after MI...
  55. Viral Mediated Type I Interferon Induction
    Genhong Cheng; Fiscal Year: 2013
    ..known as type I IFNs, which signal through the type I IFN receptor (IFNAR1), leading to activation of the JAK/STAT pathway and subsequent induction of a large set of genes important in antiviral responses...
  56. Neuroimmune Mechanisms of Glucocorticoid Resistance
    Andrew H Miller; Fiscal Year: 2010
    ..signaling pathways in the regulation of GR, and 3) to investigate the relationship between intracellular p38, JNK, STAT, and NF-kB signaling pathways and PKA signaling pathways as they relate to GR signaling, neuroendocrine function ..
  57. Therapeutic Intervention of the JAK/STAT Pathway for Neuroinflammation
    Etty N Benveniste; Fiscal Year: 2013
    ..The JAK/STAT pathway is used by cytokines for signaling, and is critical for the development, regulation and termination of ..
  58. IEX-1 in bridge of innate to adaptive immune responses to memory T cells
    Mei X Wu; Fiscal Year: 2010
    ..Additionally, we will investigate whether and how IEX-1 transcription can be activated by specific Stat proteins in responses to stimulation with cytokines like IL-7, IL-15 or IL-12 that are crucial for the survival of ..
  59. Type 1 IFN Function and Signaling in Immunity to Viruses
    CHRISTINE ANNE BIRON; Fiscal Year: 2013
    ..cytokines do stimulate a signaling pathway, depending on the signal transducers and activators of transcription (STAT) 1 and 2, but they can conditionally activate all of the STATs, including STAT4...
  60. Indoleamine 2, 3 dioxygenase signaling and function in Type 1 Diabetes
    Suparna Sarkar; Fiscal Year: 2009
    ..Specifically we aim to 1) To investigate the JAK STAT signal transduction pathway involved in IDO induction in mouse and human islets...
  61. Jak/STAT signaling in human T-cell lymphomas
    Mariusz A Wasik; Fiscal Year: 2010
    ..purpose of this study is to define better the role and understand the mechanisms and consequences of aberrant Jak/STAT signaling in the pathogenesis of cancer by evaluating human T-cell lymphomas...
  62. Modulation of Microglia and T Cell Interactions in Malignant Glioma
    AMY BETH HEIMBERGER; Fiscal Year: 2013
    ..We will next modulate the activation of T cells in the tumor environment with STAT-3 blockade of the glioma infiltrating microglia...
  63. Ubiquitous pollutant acrolein inhibits IFN?? antiviral signaling: relevance to HC
    Swati Joshi-Barve; Fiscal Year: 2013
    ..be tested by examining the effects of acrolein on early IFN1-mediated signaling (including components of the Jak/STAT pathway) and antiviral gene expression using well established in vitro and in vivo experimental systems, as well as ..
  64. Functional Analysis of ACAT
    Ta Yuan Chang; Fiscal Year: 2013
    ..The current proposal has two main goals: to continue to conduct structure-function analysis of ACAT1 in vitro, and to examine the role of macrophage ACAT1 in vivo in the Apoe-/- mouse model and the Ldlr-/- apoB48-..
  65. Role of Stat3 in Breast Cancer Tumorigenesis
    Jacqueline F Bromberg; Fiscal Year: 2010
    ..b>Stat activation is commonly seen in cancer and in particular activated Stat3 is found in ~50% of breast cancer-derived ..
  66. Hepatocarcinogenesis Secondary to Hepatitis C
    Srikanta Dash; Fiscal Year: 2012
    ..We have developed interferon-resistant replicon cell lines and determined that a defect in the Jak-Stat signaling pathway can lead to low-level activation of ISRE promoter (IFN-promoter) and interferon resistance ..
  67. IFN-Is at the interface of Innate and Adapative Immunity
    Christian W Schindler; Fiscal Year: 2010
    ..of the ability of IFN-alpha to rapidly induce genes led to the identification of Stat1 and Stat2, the first two STAT transcription factors...
  68. Mechanisms of cancer initiation by TRIM32
    Molly F Kulesz-Martin; Fiscal Year: 2012
    ..an enzyme that is needed for tumor suppression and cell survival mediated by important gene regulators p53, NFB, STAT and Smad/TGFbeta), providing the first evidence for how Piasy is regulated in cells...
  69. Beauveriolide-Derived Cyclodepsipeptides as a New Class of Anti-Alzheimer's Drugs
    Paul Wentworth; Fiscal Year: 2010
    ..Compounds that perturb cellular free cholesterol homeostasis such as acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitors have been shown both in vitro and in vivo to reduce A2 production and secretion...
  70. PARACRINE REGULATION: SERTOLI/GERM CELL INTERACTIONS
    DR PATRICIA MORRIS; Fiscal Year: 2003
    ..g. STAT-GAS DNA binding complexes) in the promoters of cytokine-responsive genes, thereby influencing critical transitions ..
  71. Funtional Genomics of Interferon for Tuberculosis
    Richard Pine; Fiscal Year: 2005
    ..Signaling is transduced through activation of STAT-1, a latent transcription factor, and leads to induced expression of other transcription factors...
  72. SYNTHESIS OF HELMINTHOSPOROL ANALOGS AS ACAT INHIBITORS
    EDUARD CASILLAS; Fiscal Year: 2004
    ..Acyl-CoA cholesterol acyltransferase (ACAT) catalyzes the intracellular esterification of cholesterol with long chain coenzyme A-activated fatty acids...
  73. CELL MUTANTS DEFECTIVE IN CHOLESTEROL ESTER FORAMTION
    Ta Yuan Chang; Fiscal Year: 2003
    Acyl coenzyme A: cholesterol acyltransferase (ACAT) catalyzes the formation of intracellular cholesterol esters...
  74. JAK-STAT Signaling in Human Heart Failure
    Christine Moravec; Fiscal Year: 2007
    ..Among these is the JAK-STAT pathway, which is present in cardiac myocytes, is activated during hypertrophy, and can be shown to be stimulated ..