SOAT1

Summary

Gene Symbol: SOAT1
Description: sterol O-acyltransferase 1
Alias: ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT, acyl-coenzyme A:cholesterol acyltransferase 1, sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
Species: human

Top Publications

  1. ncbi Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis
    L L Rudel
    Arteriosclerosis Research Program, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Lipidol 12:121-7. 2001
  2. ncbi Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT)
    Jennifer A Locke
    Department of Urologic Sciences, University of British Columbia, The Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada
    Prostate 68:20-33. 2008
  3. ncbi Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes
    P Oelkers
    Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 273:26765-71. 1998
  4. ncbi Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells
    C C Chang
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755
    J Biol Chem 268:20747-55. 1993
  5. ncbi Human acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes
    B L Li
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 274:11060-71. 1999
  6. ncbi Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains
    S Lin
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 274:23276-85. 1999
  7. ncbi Human acyl-coenzyme A:cholesterol acyltransferase 1 (acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional sequence at the N terminus
    Li Yang
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Rd, Shanghai 200031, China
    J Biol Chem 279:46253-62. 2004
  8. ncbi Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease
    M A Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Mol Psychiatry 8:635-8. 2003
  9. ncbi The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain
    Zhan Yun Guo
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    J Biol Chem 280:37814-26. 2005
  10. pmc Knockdown of ACAT-1 reduces amyloidogenic processing of APP
    Henri J Huttunen
    Neurobiology of Disease Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States
    FEBS Lett 581:1688-92. 2007

Research Grants

  1. Regulation of mucous cell metaplasia in asthma
    Yohannes Tesfaigzi; Fiscal Year: 2006
  2. Functional Analysis of ACAT
    Ta Yuan Chang; Fiscal Year: 2009
  3. CYTOKINE REGULATION OF CIITA AND CLASS II MHC IN GLIA
    ETTY BENVENISTE; Fiscal Year: 1999
  4. Therapeutic Strategies for Environmental Lung Diseases
    James Bonner; Fiscal Year: 2007
  5. ASSEMBLY PATHWAY OF VLDL--A THREE STEP PROCESS
    LARRY SWIFT; Fiscal Year: 2001
  6. PARACRINE REGULATION: SERTOLI/GERM CELL INTERACTIONS
    DR PATRICIA MORRIS; Fiscal Year: 2003
  7. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory Dressler; Fiscal Year: 2002
  8. Functional Analysis of ACAT
    Ta Yuan Chang; Fiscal Year: 2010
  9. Functional Analysis of ACAT
    Ta Yuan Chang; Fiscal Year: 2007
  10. Cell proliferation in hematopoiesis
    RUTH M STEWARD; Fiscal Year: 2010

Detail Information

Publications168 found, 100 shown here

  1. ncbi Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis
    L L Rudel
    Arteriosclerosis Research Program, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Lipidol 12:121-7. 2001
    ..responsible for cholesterol ester formation in tissues, acyl coenzyme A:cholesterol acyltransferase types 1 and 2 (ACAT1 and ACAT2)...
  2. ncbi Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT)
    Jennifer A Locke
    Department of Urologic Sciences, University of British Columbia, The Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada
    Prostate 68:20-33. 2008
    ..The objective of this work was to determine the effect of an androgen agonist, R1881, on intracellular cholesterol synthesis and esterification in androgen-sensitive (AS) prostate cancer (LNCaP) cells...
  3. ncbi Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes
    P Oelkers
    Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 273:26765-71. 1998
    The enzyme acyl coenzyme A:cholesterol acyltransferase 1 (ACAT1) mediates sterol esterification, a crucial component of intracellular lipid homeostasis...
  4. ncbi Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells
    C C Chang
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755
    J Biol Chem 268:20747-55. 1993
    ..element in forming cholesterol ester from cholesterol is the enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT). ACAT is a membrane protein located in the endoplasmic reticulum...
  5. ncbi Human acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes
    B L Li
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 274:11060-71. 1999
    Acyl-CoA:cholesterol acyltransferase (ACAT) plays important roles in cellular cholesterol homeostasis. Four human ACAT-1 mRNAs (7.0, 4.3, 3.6, and 2...
  6. ncbi Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains
    S Lin
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 274:23276-85. 1999
    Acyl-CoA:cholesterol acyltransferase (ACAT) plays important roles in cellular cholesterol homeostasis and is involved in atherosclerosis. ACAT-1 protein is located mainly in the ER...
  7. ncbi Human acyl-coenzyme A:cholesterol acyltransferase 1 (acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional sequence at the N terminus
    Li Yang
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Rd, Shanghai 200031, China
    J Biol Chem 279:46253-62. 2004
    A rare form of human ACAT1 mRNA, containing the optional long 5'-untranslated region, is produced as a 4...
  8. ncbi Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease
    M A Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Mol Psychiatry 8:635-8. 2003
    A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P=0...
  9. ncbi The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain
    Zhan Yun Guo
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    J Biol Chem 280:37814-26. 2005
    ..within the region of amino acids 354-493, expressed these mutants in Chinese hamster ovary cells lacking ACAT1, and prepared microsomes from transfected cells...
  10. pmc Knockdown of ACAT-1 reduces amyloidogenic processing of APP
    Henri J Huttunen
    Neurobiology of Disease Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States
    FEBS Lett 581:1688-92. 2007
    Previous studies have shown that acyl-coenzyme A:cholesterol acyl transferase (ACAT), an enzyme that controls cellular equilibrium between free cholesterol and cholesteryl esters, modulates proteolytic processing of APP in cell-based and ..
  11. ncbi ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization
    S Cases
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141, USA
    J Biol Chem 273:26755-64. 1998
    ..Mouse tissue expression studies and the disruption of the mouse ACAT gene (Acact) have indicated that more than one ACAT exists in mammals and specifically that another enzyme is important in ..
  12. ncbi Association between acyl-coenzyme A: cholesterol acyltransferase gene and risk for Alzheimer's disease in Chinese
    Fa Guo Zhao
    Department of Neurology, First Hospital of Peking University, Beijing, China
    Neurosci Lett 388:17-20. 2005
    ..A single nucleotide polymorphism rs1044925 in the sterol O-acyltransferase 1 (SOAT1), the gene encoding ACAT1, has been reported to be association with an increased risk for sporadic AD (SAD) in ..
  13. pmc Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues
    N Sakashita
    Second Department of Pathology, Kumamoto University School of Medicine, Kumamoto, Japan
    Am J Pathol 156:227-36. 2000
    To investigate the distribution of acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) in various human tissues, we examined tissues of autopsy cases immunohistochemically...
  14. ncbi [Treatment of cardiac insufficiency: does treatment depend on whether its cause is ischemic or idiopathic?]
    M Galinier
    Service de cardiologie clinique et expérimentale, Centre hospitalo universitaire de Toulouse Rangueil
    Arch Mal Coeur Vaiss 92:727-32. 1999
    ..of patients with non-ischaemic cardiomyopathy, contrasting with the absence of an effect with this molecule in the STAT-CHF trial which only comprised 29% of patients with non-ischaemic cardiomyopathy...
  15. ncbi Toxicologic effects of a novel acyl-CoA:cholesterol acyltransferase inhibitor in cynomolgus monkeys
    J F Reindel
    Department of Pathology, Parke Davis Pharmaceutical Research, Division of Warner Lambert Company, Ann Arbor, Michigan 48105
    Toxicol Pathol 22:510-8. 1994
    PD 132301-2, an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, was administered orally to cynomolgus monkeys for 2 wk at doses of 25, 50, 100, and 200 mg/kg to assess potential subacute toxicity...
  16. ncbi [Specific treatment of the acute cerebral infarct. Present and future]
    J J Muñoz-Torrero
    Servicio de Neurologia, Unidad de Ictus, Hospital Universitario La Paz, Universidad Autonoma de Madrid, Madrid, Espana
    Rev Neurol 31:959-82. 2000
    ..Regarding Ancrod, a recent North American study (STAT) with administration of it within three hours showed significant benefit three months later...
  17. ncbi [Cardiac insufficiency: prevention of ventricular arrhythmias]
    P Mabo
    , CHU, Rennes
    Arch Mal Coeur Vaiss 93:23-8. 2000
    ..have not been demonstrated, especially in view of the discordance between the results of the GESICA and CHF STAT trials...
  18. ncbi Mucosal acidification and an acid microclimate in the hen colon in vitro
    G Laverty
    School of Life and Health Sciences, University of Delaware, Newark 19716
    J Comp Physiol B 163:633-41. 1994
    ..Titration measurements of the mucosal acidification rate (pH-stat technique) averaged 1.63 +/- 0.25 microEq.cm-2.h-1...
  19. ncbi Protective effects of prostaglandins in the isolated gastric mucosa of the eel, Anguilla anguilla
    C Faggio
    Istituto di Fisiologia Generale, , Salita Sperone, Sant Agata, Italy
    J Comp Physiol B 170:357-63. 2000
    ..PGE2) on acid secretion rate (J(H)) and on alkaline secretion rate (J(OH)) were evaluated (with the aid of the pH stat method) in isolated gastric mucosa mounted in Ussing chambers...
  20. pmc Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells
    Courtney R Plumlee
    Department of Laboratory Medicine, University of Washington, Seattle, USA
    Virol J 2:89. 2005
    ..To model the molecular mechanisms behind this phenotype, we characterized the effects of ethanol on Jak-Stat and MAPK pathways in Huh7 human hepatoma cells, in HCV replicon cell lines, and in primary human hepatocytes...
  21. ncbi Members of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway are present and active in human sperm
    O J D'Cruz
    Department of Reproductive Biology, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Fertil Steril 76:258-66. 2001
    To investigate whether components of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway are present and active in human sperm.
  22. pmc The effects of sterol structure upon sterol esterification
    Don S Lin
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Atherosclerosis 208:155-60. 2010
    Cholesterol is esterified in mammals by two enzymes: LCAT (lecithin cholesterol acyltransferase) in plasma and ACAT(1) and ACAT(2) (acyl-CoA cholesterol acyltransferases) in the tissues...
  23. ncbi Up-regulation of acyl-coenzyme A:cholesterol acyltransferase (ACAT) in nephrotic syndrome
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, Irvine, California, USA
    Kidney Int 61:1769-75. 2002
    ..is inhibited and Ch-7alpha is augmented by intracellular free cholesterol, which is avidly esterified by acyl-CoA:cholesterol acyltransferase (ACAT). Therefore, we hypothesized that NS may result in up-regulation of hepatic ACAT.
  24. pmc Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events
    Leticia Quintanilla-Martinez
    Institutes of Pathology, GSF National Research Center for Health and Environment, Neuherberg, Germany
    Am J Pathol 162:1449-61. 2003
    ..Recently, it was proposed that constitutively activated Stat 3 (Stat 3 phosphorylated) contributes to the pathogenesis of multiple myeloma (MM) by preventing apoptosis and ..
  25. ncbi Leukemia inhibitory factor and NGF regulate signal transducers and activators of transcription activation in sympathetic ganglia: convergence of cytokine- and neurotrophin-signaling pathways
    P Rajan
    Molecular Neurobiology Laboratory, Massachusetts General Hospital, Boston 02114, USA
    Brain Res 802:198-204. 1998
    ..leukemia inhibitory factor (LIF)-dependent activation of signal transducers and activators of transcription (STAT) factors...
  26. ncbi Bladder tumor markers: need, nature and application. 2. Tumor and tumor-associated antigens
    M M Kirollos
    Urology Department, Torbay Hospital, South Devon Health Care Trust, UK
    Int Urogynecol J Pelvic Floor Dysfunct 9:228-35. 1998
    ..These are currently the Bard BTA, BTA Stat and Aura-Tek FDP tests...
  27. ncbi A community-based evaluation of the Vita-Stat automatic blood pressure recorder
    K Salaita
    Department of Epidemiology, Johns Hopkins University School of Public Health and Hygiene, Baltimore, Maryland
    Am J Hypertens 3:366-72. 1990
    A random sample of ten community-based Vita-Stat automatic blood pressure recorders (ABPR) was evaluated for accuracy and repeatability...
  28. ncbi Phlebotomine sandflies (Diptera: Psychodidae) of Tamil Nadu and Pondicherry, southern India, in relation to visceral leishmaniasis
    K Ilango
    Zoological Survey of India, Southern Regional Station, Madras
    Ann Trop Med Parasitol 88:413-31. 1994
    ..A new species, Sergentomyia shettyi sp. nov., is described and Sergentomyia babu and Sergentomyia insularis stat. nov. are considered distinct species on the basis of their parapatric distribution. Phlebotomus papatasi and P...
  29. ncbi Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro
    P J Uelmen
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 270:26192-201. 1995
    Acyl-coenzyme A:cholesterol acyltransferase (ACAT) catalyzes the esterification of cholesterol with long chain fatty acids and is believed to play an important part in the development of atherosclerotic lesions...
  30. ncbi Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1
    Yan Ru Su
    Atherosclerosis Research Unit, Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tenn 37232 6300, USA
    Circulation 111:2373-81. 2005
    Macrophage acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) and apolipoprotein E (apoE) have been implicated in regulating cellular cholesterol homeostasis and therefore play critical roles in foam cell formation...
  31. doi Repression of Wasp by JAK/STAT signalling inhibits medial actomyosin network assembly and apical cell constriction in intercalating epithelial cells
    Claire Bertet
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Development 136:4199-212. 2009
    ..We report that apical constriction is repressed by JAK/STAT signalling in the lateral ectoderm independently of Twist...
  32. ncbi Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain
    D C van der Plas
    Department of Hematology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Leukemia 10:1317-25. 1996
    ..Activation of the JAK/STAT pathway has been implicated in IL-7R signaling...
  33. ncbi NMP 22, BTA stat test and cytology in the diagnosis of bladder cancer: a comparative study
    J L Gutierrez Banos
    Department of Urology, Marques de Valdecilla University Hospital, Santander, Spain
    Urol Int 66:185-90. 2001
    To evaluate the usefulness of the NMP 22 and BTA stat test in the diagnosis and follow-up of bladder cancer and to compare these tests to cytology and cystoscopy, routine diagnostic methods.
  34. ncbi STAT proteins mediate angiotensin II-induced production of TIMP-1 in human proximal tubular epithelial cells
    XiangMei Chen
    Department of Nephrology, Chinese General Hospital of PLA, Beijing, China
    Kidney Int 64:459-67. 2003
    ..Angiotensin II has been reported to activate signal transducers and activators of transcription (STAT) and induce proliferation of myocyte and vascular smooth muscle cells (VSMC)...
  35. ncbi Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6)
    Joachim Geyer
    Institute of Pharmacology and Toxicology, Justus Liebig University of Giessen, Frankfurter Strasse 107, 35392 Giessen, Germany
    J Biol Chem 282:19728-41. 2007
    We have cloned human sodium-dependent organic anion transporter (SOAT) cDNA, which consists of 1502 bp and encodes a 377-amino acid protein...
  36. doi Quasi steady state growth of Lactococcus lactis in glucose-limited acceleration stat (A-stat) cultures
    Kaarel Adamberg
    Department of Food Processing, Tallinn University of Technology, Ehitajate tee 5, Tallinn, Estonia
    Antonie Van Leeuwenhoek 95:219-26. 2009
    Quasi steady state growth of Lactococcus lactis IL 1403 was studied in glucose-limited A-stat cultivation experiments with acceleration rates (a) from 0.003 to 0.06 h(-2) after initial stabilization of the cultures in chemostat at D = 0...
  37. ncbi The optional long 5'-untranslated region of human ACAT1 mRNAs impairs the production of ACAT1 protein by promoting its mRNA decay
    Xiaonan Zhao
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Acta Biochim Biophys Sin (Shanghai) 41:30-41. 2009
    We have previously reported that human ACAT1 mRNAs produce the 50 kDa protein using the AUG(11397-1399) initiation codon, and also a minor 56 kDa isoform using the upstream in-frame GGC(1274-1276) initiation codon...
  38. ncbi Effects of pH management during selective antegrade cerebral perfusion on cerebral microcirculation and metabolism: alpha-stat versus pH-stat
    Sebastian Dahlbacka
    Department of Surgery, Clinical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland
    Ann Thorac Surg 84:847-55. 2007
    ..Selective cerebral perfusion (SCP) is used for extending the period during which surgical procedures can be safely performed. We sought to determine the direct effects of pH management on cerebral microcirculation and metabolism during SCP...
  39. doi ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: the CAPTIVATE randomized trial
    Marijn C Meuwese
    Department of Vascular Medicine, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    JAMA 301:1131-9. 2009
    Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT), an intracellular enzyme involved in cholesterol accumulation, with pactimibe was developed to assist in the prevention of cardiovascular disease.
  40. ncbi Effect of ACAT inhibition on the progression of coronary atherosclerosis
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 354:1253-63. 2006
    The enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) esterifies cholesterol in a variety of tissues. In some animal models, ACAT inhibitors have antiatherosclerotic effects.
  41. pmc Purification of recombinant acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) from H293 cells and binding studies between the enzyme and substrates using difference intrinsic fluorescence spectroscopy
    Catherine C Y Chang
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, United States
    Biochemistry 49:9957-63. 2010
    Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is a membrane-bound enzyme utilizing long-chain fatty acyl-coenzyme A and cholesterol to form cholesteryl esters and coenzyme A...
  42. ncbi Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome
    N D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, USA
    Circulation 110:419-25. 2004
    ..Acyl-coenzyme A:cholesterol acyltransferase (ACAT) catalyzes intracellular esterification of cholesterol and plays an important role in production of apolipoprotein ..
  43. ncbi Inhibition of adrenergic proton extrusion in rainbow trout red cells by nitrite-induced methaemoglobinaemia
    M Nikinmaa
    Department of Zoology, University of Helsinki, Finland
    J Comp Physiol B 162:424-9. 1992
    ..methaemoglobinaemia on adrenergic proton extrusion from rainbow trout red blood cells were studied using the pH-stat method...
  44. ncbi Lack of toxic effects of F 12511, a novel potent inhibitor of acyl-coenzyme A: cholesterol O-acyltransferase, on human adrenocortical cells in culture
    D Junquero
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Castres Cedex, France
    Biochem Pharmacol 61:387-98. 2001
    Inhibition of acyl-coenzyme A: cholesterol O-acyltransferase (EC 2.3.1.26; ACAT) reduces intracellular cholesteryl esters that are substrates for steroidogenesis in adrenal cells...
  45. ncbi Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I
    Don Fleenor
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Horm Res 66:101-10. 2006
    ..of GHR and PRLR mRNAs in 3T3-L1 preadipocytes during the course of adipocyte differentiation; (b) the induction of STAT-5 activity by GH and PRL during adipogenesis; and (c) the acute effects of GH and PRL on the suppressors of ..
  46. ncbi Effects of the acyl coenzyme A:cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions
    Jean Claude Tardif
    Montreal Heart Institute, 5000 Belanger St, Montreal, H1T 1C8, Canada
    Circulation 110:3372-7. 2004
    Inhibition of the acyl coenzyme A:cholesterol acyltransferase (ACAT) enzyme may prevent excess accumulation of cholesteryl esters in macrophages. The ACAT inhibitor avasimibe was shown to reduce experimental atherosclerosis...
  47. ncbi Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis
    Mari A Nowell
    Medical Biochemistry and Immunology, Tenovus Building, School of Medicine, Heath Park Campus, Cardiff University, Cardiff CF14 4XN, UK
    Arthritis Rheum 54:2084-95. 2006
    ..To determine whether interleukin-6 (IL-6) trans-signaling directs the expression of pre-B cell colony-enhancing factor (PBEF) in vitro and in vivo...
  48. ncbi [Ghrelin down-regulates ACAT-1 in THP-1 derived foam cells via growth hormone secretagogue receptor-dependent pathway]
    Jing jing Wan
    Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:1030-4. 2009
    To investigate the effects of Ghrelin on the expression of acyl coenzyme A:cholesterol acyltransferases-1 (ACAT-1) in THP-1 derived foam cells.
  49. ncbi Receptor-mediated tobacco toxicity: cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of alpha7 nicotinic receptor in oral keratinocytes
    Juan Arredondo
    Department of Dermatology, University of California Davis, Sacramento, CA, USA
    FASEB J 20:2093-101. 2006
    ..chain reaction (PCR) and In-cell Western, the KCs stimulated with ADSS or nicotine showed multifold increases of STAT-3. These effects could be completely blocked or significantly (P<0...
  50. ncbi Bladder tumor markers for monitoring recurrence and screening comparison of hyaluronic acid-hyaluronidase and BTA-Stat tests
    Vinata B Lokeshwar
    Department of Urology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Cancer 95:61-72. 2002
    ..The authors examined the efficacy of the hyaluronic acid-hyaluronidase (HA-HAase) and BTA-Stat tests to detect and predict bladder carcinoma recurrence and tested their specificity for bladder carcinoma ..
  51. ncbi Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia
    H Yagyu
    Departments of Metabolic Diseases, Ophthalmology, Pathology, Faculty of Medicine, University of Tokyo, Hongo, Tokyo 113 8655, Japan
    J Biol Chem 275:21324-30. 2000
    Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes esterification of cellular cholesterol. To investigate the role of ACAT-1 in atherosclerosis, we have generated ACAT-1 null (ACAT-1-/-) mice...
  52. ncbi Routine follow-up cystoscopy in detection of recurrence in patients being monitored for bladder cancer
    M P Raitanen
    Department of Urology, Tampere University Hospital, Finland
    Ann Chir Gynaecol 90:261-5. 2001
    ..Therefore, new tumour markers have been developed. BTA stat has been reported to have high sensitivity in detecting both primary and recurrent bladder tumours, and may have ..
  53. ncbi Brain cooling efficiency with pH-stat and alpha-stat cardiopulmonary bypass in newborn pigs
    C D Kurth
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, PA 19104, USA
    Circulation 96:II-358-63. 1997
    ..surgery, recent studies suggest improved neurological outcome after deep hypothermic circulatory arrest when pH-stat cardiopulmonary bypass is used compared with alpha-stat cardiopulmonary bypass...
  54. ncbi Activation of signal transducers and activators of transcription 1 and 3 by leukemia inhibitory factor, oncostatin-M, and interferon-gamma in adipocytes
    J M Stephens
    Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    J Biol Chem 273:31408-16. 1998
    ..IFNgamma is shown to be a potent activator of STAT 1 as indicated by both tyrosine phosphorylation and nuclear translocation...
  55. ncbi [Chlamydia pneumoniae induces THP-1-derived foam cell formation by up-regulating the expression of acyl-coenzyme A: cholesterol acyltransferase 1]
    Ping He
    Department of Gerontology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:430-5. 2009
    To investigate the expression changes of acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) on Chlamydia pneumoniae (C.pn) induced foam cell formation.
  56. ncbi Novel effects of the acyl-coenzyme A:Cholesterol acyltransferase inhibitor 58-035 on foam cell development in primary human monocyte-derived macrophages
    A Rodriguez
    Department of Medicine, Sinai Hospital of Baltimore, MD 21215
    Arterioscler Thromb Vasc Biol 19:2199-206. 1999
    We examined the effect of acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitors on intracellular cholesterol stores in primary human monocyte-derived macrophages (HMMs) during foam cell formation...
  57. ncbi Evaluation of the i-STAT point-of-care analyzer in critically ill adult patients
    Jacoline Steinfelder-Visscher
    Department of Extra Corporeal Circulation, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Extra Corpor Technol 40:57-60. 2008
    ..We therefore evaluated the analytical performance of the i-STAT point-of-care analyzer in two critically ill adult patient populations...
  58. ncbi The effect of inhibition of acyl coenzyme A-cholesterol acyltransferase (ACAT) on exercise performance in patients with peripheral arterial disease
    William R Hiatt
    Section of Vascular Medicine, University of Colorado Health Sciences Center, 4200 E 9th Ave, Denver, CO 80262, USA
    Vasc Med 9:271-7. 2004
    This study tested the hypothesis that avasimibe, an inhibitor of acyl coenzyme A-cholesterol acyltransferase (ACAT), would improve treadmill exercise performance in patients with claudication secondary to peripheral arterial disease (PAD)...
  59. doi Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: an implication for the pathogenesis of arthritis
    Sang Heng Kok
    School fo Dentistry, College of Medicine, National Taiwan University, and National Taiwan University Hospital, Taipei, Taiwan
    Arthritis Rheum 60:1451-62. 2009
    ..To examine the roles of STATs 1 and 3 in CCL2 production in human osteoblastic cells and their influences on arthritis development...
  60. doi Inhibition of Janus kinase 2 and signal transduction and activator of transcription 3 protect against cecal ligation and puncture-induced multiple organ damage and mortality
    Liu Hui
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to Chinese PLA General Hospital formerly 304th Hospital, Beijing 100037, People s Republic of China
    J Trauma 66:859-65. 2009
    Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway plays an important role in sepsis, transducing a multitude of inflammatory signals. To date, knowledge of JAK/STAT pathway in sepsis is limited...
  61. ncbi Functionality of the seventh and eighth transmembrane domains of acyl-coenzyme A:cholesterol acyltransferase 1
    Zhan Yun Guo
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Biochemistry 46:10063-71. 2007
    Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is a resident enzyme in the endoplasmic reticulum. ACAT1 is a homotetrameric protein and contains nine transmembrane domains (TMDs)...
  62. ncbi Roles for the interleukin-4 receptor and associated JAK/STAT proteins in human articular chondrocyte mechanotransduction
    S J Millward-Sadler
    Osteoarticular Research Group, Division of Pathology, University of Edinburgh, Medical School, Edinburgh, EH8 9AG, UK
    Osteoarthritis Cartilage 14:991-1001. 2006
    ..IL4) receptor (IL4R) subtypes and associated Janus kinase/signal transducers and activators of transcription (JAK/STAT) molecules in human articular chondrocytes and assess the role of JAK/STAT proteins in chondrocyte ..
  63. ncbi Using STAT properly
    William Wesp
    University of Minnesota Medical Center, Fairview, Minneapolis, USA
    Radiol Manage 28:26-30; quiz 31-3. 2006
    The misuse of the term STAT has long been a problem in many hospitals. Instead of being the universal word for "immediate," it has become a convenient phrase used, in some cases, to get what the physician wants now...
  64. ncbi Comparison of pH-stat and alpha-stat cardiopulmonary bypass on cerebral oxygenation and blood flow in relation to hypothermic circulatory arrest in piglets
    C D Kurth
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine 19104, USA
    Anesthesiology 89:110-8. 1998
    ..Recent work has suggested improved neurologic recovery after deep hypothermic arrest with pH-stat cardiopulmonary bypass (CPB) compared with alpha-stat CPB...
  65. ncbi Specificity of transcription enhancement via the STAT responsive element in the serine protease inhibitor 2.1 promoter
    T J Wood
    Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Mol Cell Endocrinol 130:69-81. 1997
    ..to the gamma-interferon activated sequence (GAS) family of signal transducer and activator of transcription (STAT) response elements. We have investigated the STAT and cytokine specificity of the SPI 2...
  66. ncbi Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cells
    T Seo
    Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, 630W 168th Street PH1512, New York, New York 10032, USA
    Biochemistry 40:4756-62. 2001
    ..Two ACAT genes have been identified; ACAT1 is expressed ubiquitously while ACAT2 is primarily expressed in intestine and liver...
  67. ncbi Molecular cloning, functional expression and tissue distribution of rat acyl-coenzyme A:cholesterol acyltransferase
    H Matsuda
    Department of Biochemistry, Kumamoto University School of Medicine, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Biochim Biophys Acta 1391:193-203. 1998
    Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an enzyme catalyzing the intracellular formation of cholesteryl esters from free cholesterol and fatty acyl-CoA...
  68. ncbi Effect of intravesical instillations on the human complement factor H related protein (BTA stat) test
    M P Raitanen
    Division of Urology, Tampere University Hospital, Tampere, Finland
    Eur Urol 40:422-6. 2001
    The BTA stat is a rapid, non-invasive, qualitative urine test that detects bladder tumor-associated antigen (human complement factor H related protein) in urine...
  69. doi Chlamydia pneumoniae induces macrophage-derived foam cell formation by up-regulating acyl-coenzyme A: cholesterol acyltransferase 1
    Ping He
    Department of Gerontology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jie Fang Avenue, Wuhan 430022, Hubei Province, China
    Microbes Infect 11:157-63. 2009
    ..In macrophages, the accumulation of cholesteryl esters synthesized by acyl-coenzyme A: cholesterol acyltransferase 1(ACAT1) plays a crucial role in foam cell formation, a hallmark of early atherosclerotic lesions...
  70. ncbi Discovery and combinatorial synthesis of fungal metabolites beauveriolides, novel antiatherosclerotic agents
    Hiroshi Tomoda
    School of Pharmacy, Kitasato University, Shirokane, Minato ku, Tokyo 108 8641, Japan
    Acc Chem Res 41:32-9. 2008
    ..There are two ACAT isozymes in mammals, ACAT1 and ACAT2...
  71. ncbi Nutritional status of the population in Dalmatia, Croatia
    N Smolej-Narancic
    Institute for Anthropological Research, Zagreb, Croatia
    Coll Antropol 23:59-68. 1999
    ..Elucidation of these effects will provide information on the adequacy of NHANES data for the assessment of nutritional stat+us in Dalmatian population.
  72. pmc Emergency medicine and the laboratory
    E Hardin
    Department of Emergency Medicine, King Drew Medical Center, Los Angeles, CA 90059, USA
    J Natl Med Assoc 88:279-82. 1996
    ..Special consideration is given to the requirements for a stat laboratory, which provides mandatory service for any large general hospital emergency department...
  73. ncbi Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells
    John J Liang
    Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 279:44938-44. 2004
    ..The isolation of genes encoding diacylglycerol acyltransferase (DGAT) and acyl-CoA:cholesterol acyltransferases (ACAT1 and ACAT2) provided the opportunity to investigate the effects of isolated increases in triglycerides (TG) or ..
  74. ncbi Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages
    Toshiaki Suguro
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo 142 8666, Japan
    Atherosclerosis 186:275-81. 2006
    Acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) converts intracellular free cholesterol into cholesterol ester for storage in lipid droplets and plays an important role in the formation of macrophage-derived foam cells in ..
  75. ncbi Acyl coenzyme A:cholesterol acyltransferase inhibitors as hypolipidemic and antiatherosclerotic drugs
    M Alegret
    Unitat de Farmacologia, Departament de Farmacologia i Quimica Terapeutica, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain
    Methods Find Exp Clin Pharmacol 26:563-86. 2004
    ..Two ACAT isoforms, termed ACAT1 and ACAT2, have been described...
  76. doi Clinician and patient perspectives of a new model of triage in a community rehabilitation program that reduced waiting time: a qualitative analysis
    Katherine E Harding
    La Trobe University, Faculty of Health Sciences, Australia
    Aust Health Rev 37:324-30. 2013
    A trial of a new model of triage (Specific and Timely Appointments for Triage: STAT) at a community rehabilitation program (CRP) reduced the mean time to first appointment from 17.5 to 10.0 days...
  77. ncbi The role of STAT-3 in the mediation of smooth muscle cell response to cyclic strain
    John D Kakisis
    Department of Vascular Surgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Int J Biochem Cell Biol 37:1396-406. 2005
    ..The purpose of our study was to assess the involvement of the signal transducer and activator of transcription-3 (STAT-3) in the signaling pathway mediating the response of vascular smooth muscle cells (SMC) to cyclic strain...
  78. ncbi Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival
    Mustafa Benekli
    Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Blood 99:252-7. 2002
    Signal transducer and activator of transcription (STAT) proteins are involved in hematopoietic cytokine receptor signaling pathways that regulate cell proliferation, differentiation, and survival...
  79. pmc Polymorphism of rs1044925 in the acyl-CoA:cholesterol acyltransferase-1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations
    Dong Feng Wu
    Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China
    Lipids Health Dis 9:139. 2010
    The association of rs1044925 polymorphism in the acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene and serum lipid profiles is not well known in different ethnic groups. Bai Ku Yao is a special subgroup of the Yao minority in China...
  80. doi Role of the JAK/STAT signaling pathway in the pathogenesis of acute myocardial infarction in rats and its effect on NF-κB expression
    Song Zhang
    Department of Cardiovascular Diseases, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200092, PR China
    Mol Med Rep 7:93-8. 2013
    The Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT signaling pathway) is involved in the development of numerous cardiovascular diseases, although the specific role of this pathway in the pathogenesis of ..
  81. doi Ultrathin sP(EO-stat-PO) hydrogel coatings are biocompatible and preserve functionality of surface bound growth factors in vivo
    Carl Neuerburg
    Department of Orthopaedics, University of Ulm, Ulm, Germany
    J Mater Sci Mater Med 24:2417-27. 2013
    Hydrogel coatings prepared from reactive star shaped polyethylene oxide based prepolymers (NCO-sP(EO-stat-PO)) minimize unspecific protein adsorption in vitro, while proteins immobilized on NCO-sP(EO-stat-PO) coatings retain their ..
  82. doi Beclomethasone dipropionate and formoterol reduce oxidative/nitrosative stress generated by cigarette smoke extracts and IL-17A in human bronchial epithelial cells
    Angela Marina Montalbano
    Institute of Biomedicine and Molecular Immunology IBIM, Italian National Research Council CNR, Palermo, Italy
    Eur J Pharmacol 718:418-27. 2013
    ..oxygen species, nitrotyrosine (NT) and the activation of signal transducer and activator of transcription 1 (STAT-1) in normal human bronchial epithelial cells (16HBE)...
  83. doi Ring-closing metathesis reactions: interpretation of conversion-time data
    Vasco Thiel
    Organometallic Chemistry, Petersenstrasse 18, TU Darmstadt, 64287 Darmstadt Germany
    Chemistry 19:16403-14. 2013
    ..data was derived, which is based on the conversion of the precatalyst (Pcat) into the active species (Acat), with the rate constant kact , followed by two parallel reactions: 1) the catalytic reaction, which utilizes ..
  84. ncbi Initiation and maintenance of CNTF-Jak/STAT signaling in neurons is blocked by protein tyrosine phosphatase inhibitors
    Jianwei Jiao
    Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, 102 Farber Hall, The State University of New York at Buffalo, Buffalo, NY 14214 3000, USA
    Brain Res Mol Brain Res 116:135-46. 2003
    ..including interferon-gamma and ciliary neurotrophic factor (CNTF), act in common through tyrosine kinase-based Jak/STAT signaling pathways...
  85. ncbi Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2
    T Y Chang
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Curr Opin Lipidol 12:289-96. 2001
    ..In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified...
  86. doi Cloning, molecular characterization, and expression analysis of the signal transducer and activator of transcription 3 (STAT₃) gene from grass carp (Ctenopharyngodon idellus)
    Ting Guo
    The College of Fisheries and Life Science, Shanghai Ocean University, No 999, Huchenghuan Road, Shanghai 201306, China Key Laboratory of Freshwater Fishery Germplasm Resources, Ministry of Agriculture, No 999, Huchenghuan Road, Shanghai 201306, China Shanghai Engineering Research Center of Aquaculture, No 999, Huchenghuan Road, Shanghai 201306, China Shanghai University Knowledge Service Platform, Shanghai Ocean University Aquatic Animal Breeding Center, No 999, Huchenghuan Road, Shanghai 201306, China
    Fish Shellfish Immunol 35:1624-34. 2013
    Signal transducer and activator of transcription 3 (STAT₃) binds to Janus kinase 2 (JAK₂) to initiate the JAK₂/STAT₃ signal transduction pathway, which plays an important role in cancer cell proliferation, immune regulation, ..
  87. ncbi Reactive oxygen species mediate virus-induced STAT activation: role of tyrosine phosphatases
    Tianshuang Liu
    Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas 77555 0366, USA
    J Biol Chem 279:2461-9. 2004
    ..this study, we have investigated the role of ROS in RSV-induced signal transducers and activators of transcription (STAT) activation and interferon regulatory factor (IRF) gene expression in human airway epithelial cells...
  88. pmc Phosphorylation of STAT-1 serine 727 is prolonged in HLA-B27-expressing human monocytic cells
    Marja Ruuska
    Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland
    PLoS ONE 8:e50684. 2013
    ..we studied whether HLA-B27 modulates the phosphorylation of signal transducer and activator of transcription 1 (STAT-1) serine 727 residue and the localization of STAT-1 in Salmonella-infected human monocytic cells...
  89. ncbi Activation of the signal transducers and activators of transcription signaling pathway by growth hormone (GH) in skin fibroblasts from normal and GH binding protein-positive Laron Syndrome children
    J S Freeth
    Department of Medicine, University of Manchester, United Kingdom
    Endocrinology 139:20-8. 1998
    ..In the present study, we have examined whether the signal transducers and activators of transcription (STAT) pathway is activated by GH in skin fibroblast cultures established from these LS children, to determine the level(..
  90. pmc Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen
    Yoshiki Hayashi
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Development 139:4162-71. 2012
    ..of the Unpaired (Upd) family activate the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway. The JAK/STAT pathway controls many developmental events, including multiple functions in the ovary...
  91. ncbi Ionization of amphiphilic acidic block copolymers
    Olivier Colombani
    PRES LUNAM, Universite du Maine, IMMM UMR CNRS 6283, Département PCI, Avenue Olivier Messiaen, 72085 Le Mans Cedex 09, France
    J Phys Chem B 116:7560-5. 2012
    The ionization behavior of an amphiphilic diblock copolymer poly(n-butyl acrylate(50%)-stat-acrylic acid(50%))(100)-block-poly(acrylic acid)(100) (P(nBA(50%)-stat-AA(50%))(100)-b-PAA(100), DH50) and of its equivalent triblock copolymer P(..
  92. pmc Isolation of Chinese hamster ovary cell lines expressing human acyl-coenzyme A/cholesterol acyltransferase activity
    K M Cadigan
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03756
    J Cell Biol 108:2201-10. 1989
    ..the isolation of Chinese hamster ovary cell mutants deficient in acylcoenzyme A/cholesterol acyltransferase (ACAT) activity (Cadigan, K. M., J. G. Heider, and T. Y. Chang. 1988, J. Biol. Chem. 263:274-282)...
  93. doi Control of the orientation of symmetric poly(styrene)-block-poly(D,L-lactide) block copolymers using statistical copolymers of dissimilar composition
    Imelda Keen
    Australian Institute of Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland 4072, Australia
    Langmuir 28:15876-88. 2012
    ..comprised of monomer units identical to those of the block copolymer is used; that is, typically a poly(styrene)-stat-poly(methyl methacrylate) (PS-stat-PMMA) is used to direct the alignment of poly(styrene)-block-poly(methyl ..
  94. pmc Expression of interleukin-8 receptor CXCR2 and suppressor of cytokine signaling-3 in astrocytic tumors
    Penelope Korkolopoulou
    First Department of Pathology, Laiko Hospital, University of Athens Medical School, Athens, Greece
    Mol Med 18:379-88. 2012
    The aim was to expand recently published information regarding the significance of the interleukin (IL)-8/p-STAT-3 (signal transducer and activator of transcription) pathway in astrocytomas, focusing on the IL-8 receptor, chemokine (C-X-C ..
  95. ncbi Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation
    V L Meiner
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 273:1064-9. 1998
    ..Two recent observations (adrenocortical lipid depletion in acyl-CoA:cholesterol acyltransferase-deficient (Acact-/-) mice and the mapping of Acact to a region of chromosome 1 containing the ald locus) prompted us to ask whether ..
  96. doi Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapy
    Silvana Gaudieri
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Australia
    Hepatology 49:1069-82. 2009
    The efficacy of specifically targeted anti-viral therapy for hepatitis C virus (HCV) (STAT-C), including HCV protease and polymerase inhibitors, is limited by the presence of drug-specific viral resistance mutations within the targeted ..
  97. ncbi Activation state EGFR and STAT-3 as prognostic markers in resected non-small cell lung cancer
    Tania Cortas
    From the Department of Medicine, Divisions of Hematology Oncology, Case Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, OH 44106, United States
    Lung Cancer 55:349-55. 2007
    ..We hypothesized that activation (phosphorylated) state of EGFR (p-EGFR) and its activated downstream signal pathway (p-STAT-3) will have prognostic value in NSCLC.
  98. pmc White spot syndrome virus annexes a shrimp STAT to enhance expression of the immediate-early gene ie1
    Wang Jing Liu
    Institute of Zoology, National Taiwan University, Taipei 106, Taiwan
    J Virol 81:1461-71. 2007
    Although the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway is part of the antiviral response in arthropods such as Drosophila, here we show that white spot syndrome virus (WSSV) uses a shrimp ..
  99. ncbi Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase
    A Becker
    Institute for Clinical Chemistry, University of Regensburg, Germany
    Arterioscler Thromb 14:1346-55. 1994
    An enzyme with acyl coenzyme A:cholesterol acyltransferase (ACAT) activity was isolated from porcine liver, and sequences derived from trypsinized peptides indicated homology to liver carboxylesterase...
  100. ncbi Activation of the signal transducer and activator of transcription-1 in diffuse proliferative lupus nephritis
    L Martinez-Lostao
    Autoimmune Diseases Research Lab, Vall d Hebron Research Institute, Barcelona, Spain
    Lupus 16:483-8. 2007
    ..rely mainly on the activity of the transcription factor called signal transducer and activator of transcription (STAT)-1...
  101. pmc Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?
    Bharat B Aggarwal
    Department of Experimental Therapeutics, Cytokine Research Laboratory, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Ann N Y Acad Sci 1171:59-76. 2009
    Signal transducer and activator of transcription-3 (STAT-3) is one of six members of a family of transcription factors. It was discovered almost 15 years ago as an acute-phase response factor...

Research Grants72

  1. Regulation of mucous cell metaplasia in asthma
    Yohannes Tesfaigzi; Fiscal Year: 2006
    ..Mice deficient in Bax or Stat 1, an obligatory signaling molecule for IFNgamma, do not resolve MCM during prolonged exposures to allergen...
  2. Functional Analysis of ACAT
    Ta Yuan Chang; Fiscal Year: 2009
    ..In mammals, two Acat genes exist that encode for two similar but different proteins, ACAT1 and ACAT2...
  3. CYTOKINE REGULATION OF CIITA AND CLASS II MHC IN GLIA
    ETTY BENVENISTE; Fiscal Year: 1999
    ..In addition, the absolute requirement of the STAT-1( protein in IFN( induced CIITA and class II expression is to be assessed in primary cultures of astrocytes and ..
  4. Therapeutic Strategies for Environmental Lung Diseases
    James Bonner; Fiscal Year: 2007
    ..IL-13-induced PDGF production by lung cells is tightly regulated by STAT transcription factors; STAT-6 promotes IL-13-induced PDGF production while STAT-1 suppresses PDGF production...
  5. ASSEMBLY PATHWAY OF VLDL--A THREE STEP PROCESS
    LARRY SWIFT; Fiscal Year: 2001
    ..will test the following hypotheses related to these assembly steps: 1) Acyl CoA cholesterol acyltransferase (ACAT) and diacylglycerol acyltransferase (DGAT) provide lipid for the first two assembly steps in the rough ER...
  6. PARACRINE REGULATION: SERTOLI/GERM CELL INTERACTIONS
    DR PATRICIA MORRIS; Fiscal Year: 2003
    ..g. STAT-GAS DNA binding complexes) in the promoters of cytokine-responsive genes, thereby influencing critical transitions ..
  7. PAX2 INTERACTING PROTEINS IN DEVELOPMENT AND DISEASE
    Gregory Dressler; Fiscal Year: 2002
    ..Given the known action of PIAS-3 to inhibit Stat-3 DNA binding, the possibility that PIAS-3 also inhibits the Pax-2 - DNA interaction will be examined using EMSA...
  8. Functional Analysis of ACAT
    Ta Yuan Chang; Fiscal Year: 2010
    ..In mammals, two Acat genes exist that encode for two similar but different proteins, ACAT1 and ACAT2...
  9. Functional Analysis of ACAT
    Ta Yuan Chang; Fiscal Year: 2007
    ..In mammals, two Acat genes exist that encode for two similar but different proteins, ACAT1 and ACAT2...
  10. Cell proliferation in hematopoiesis
    RUTH M STEWARD; Fiscal Year: 2010
    ..Pathways such as Toll-NF:B, JAK/STAT, Notch, and Ras/Raf regulate hematopoiesis in vertebrates and lymph gland development in flies...
  11. Anti viral function of interferon alpha induced human beta defensin 3
    Santanu Bose; Fiscal Year: 2007
    ..a critical anti-viral cytokine that activates Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway to induce anti-viral proteins...
  12. Funtional Genomics of Interferon for Tuberculosis
    Richard Pine; Fiscal Year: 2005
    ..Signaling is transduced through activation of STAT-1, a latent transcription factor, and leads to induced expression of other transcription factors...
  13. Immune Gene Regulation in Human Trophoblast Cells
    Shawn P Murphy; Fiscal Year: 2010
    ..Responses to IFN-3 are mediated by activation of transcription through the JAK-STAT-1 pathway...
  14. Molecular Basis of Paramyxovirus-Induced STAT Degradation
    Curt Horvath; Fiscal Year: 2009
    Type I interferon (IFN) signal transduction through STAT proteins is the paramount host response to virus infections, and its importance is underscored by the wide variety of strategies that diverse viruses have evolved to evade IFN ..
  15. Molecular Basis of Paramyxovirus-Induced STAT Degradation
    Curt M Horvath; Fiscal Year: 2010
    Type I interferon (IFN) signal transduction through STAT proteins is the paramount host response to virus infections, and its importance is underscored by the wide variety of strategies that diverse viruses have evolved to evade IFN ..
  16. Molecular Basis-Paramyxovirus-induced STAT Degradation
    Curt Horvath; Fiscal Year: 2006
    ..a DNA binding subunit in association with two proteins from the signal transducer and activator of transcription (STAT) family, STAT1 and STAT2. ISGF3 is the main effector of cellular IFN responses...
  17. SYNTHESIS OF HELMINTHOSPOROL ANALOGS AS ACAT INHIBITORS
    EDUARD CASILLAS; Fiscal Year: 2004
    ..Acyl-CoA cholesterol acyltransferase (ACAT) catalyzes the intracellular esterification of cholesterol with long chain coenzyme A-activated fatty acids...
  18. STRUCTURE/FUNCTION ANALYSIS OF ACAT
    Ta Yuan Chang; Fiscal Year: 2002
    ..Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is believed to play important roles in dietary cholesterol absorption, in hepatic lipoprotein assembly and ..
  19. ACAT inhibition regulates ERAD of APP and Abeta production
    Dora M Kovacs; Fiscal Year: 2010
    ..Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitors, which prevent conversion of cholesterol and fatty acids into cholesteryl-esters, are not currently ..
  20. ACAT inhibition regulates ERAD of APP and Abeta production
    Dora Kovacs; Fiscal Year: 2007
    ..Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitors, which prevent conversion of cholesterol and fatty acids into cholesteryl-esters, are not currently ..
  21. JAK-STAT Signaling in Human Heart Failure
    Christine Moravec; Fiscal Year: 2007
    ..Among these is the JAK-STAT pathway, which is present in cardiac myocytes, is activated during hypertrophy, and can be shown to be stimulated ..
  22. Expression and Function of SOCS Proteins in Glial Cells
    ETTY BENVENISTE; Fiscal Year: 2009
    ..pathways; the most common being the Janus Kinase (JAK) and Signal Transducer and Activator of Transcription (STAT) pathway (JAK-STAT)...
  23. Enterocyte Apoptosis after Intestinal Resection
    BRAD WAYNE WARNER; Fiscal Year: 2010
    ..proapototic Bcl02 family member Bax and the transcription factor signal transducer and activator of transcription (STAT)-1...