SOAT1

Summary

Gene Symbol: SOAT1
Description: sterol O-acyltransferase 1
Alias: ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT, sterol O-acyltransferase 1, acyl-coenzyme A:cholesterol acyltransferase 1, sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
Species: human
Products:     SOAT1

Top Publications

  1. Wollmer M, Streffer J, Tsolaki M, Grimaldi L, Lutjohann D, Thal D, et al. Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease. Mol Psychiatry. 2003;8:635-8 pubmed
    A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P=0...
  2. Chang C, Huh H, Cadigan K, Chang T. Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. J Biol Chem. 1993;268:20747-55 pubmed
    ..element in forming cholesterol ester from cholesterol is the enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT). ACAT is a membrane protein located in the endoplasmic reticulum...
  3. Oelkers P, Behari A, Cromley D, Billheimer J, Sturley S. Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. J Biol Chem. 1998;273:26765-71 pubmed
    The enzyme acyl coenzyme A:cholesterol acyltransferase 1 (ACAT1) mediates sterol esterification, a crucial component of intracellular lipid homeostasis...
  4. Sakashita N, Miyazaki A, Takeya M, Horiuchi S, Chang C, Chang T, et al. Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues. Am J Pathol. 2000;156:227-36 pubmed
    To investigate the distribution of acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) in various human tissues, we examined tissues of autopsy cases immunohistochemically...
  5. Zhao F, Wang Y, Yang J, Ma Q, Tang Z, Dong X, et al. Association between acyl-coenzyme A: cholesterol acyltransferase gene and risk for Alzheimer's disease in Chinese. Neurosci Lett. 2005;388:17-20 pubmed
    ..A single nucleotide polymorphism rs1044925 in the sterol O-acyltransferase 1 (SOAT1), the gene encoding ACAT1, has been reported to be association with an increased risk for sporadic AD (SAD) in ..
  6. Cases S, Novak S, Zheng Y, Myers H, Lear S, Sande E, et al. ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. J Biol Chem. 1998;273:26755-64 pubmed
    ..Mouse tissue expression studies and the disruption of the mouse ACAT gene (Acact) have indicated that more than one ACAT exists in mammals and specifically that another enzyme is important in ..
  7. Sun Y, Kopp S, Strutz J, Gali C, Zandl Lang M, Fanaee Danesh E, et al. Gestational diabetes mellitus modulates cholesterol homeostasis in human fetoplacental endothelium. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:968-979 pubmed publisher
    ..along with upregulated 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and sterol O-acyltransferase 1 (SOAT1) mRNA and protein levels...
  8. Lopez A, Chuang J, Posey K, Ohshiro T, Tomoda H, Rudel L, et al. PRD125, a potent and selective inhibitor of sterol O-acyltransferase 2 markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient mice. J Pharmacol Exp Ther. 2015;355:159-67 pubmed publisher
    ..all possess a varying capability of esterifying cholesterol through the action of either sterol O-acyltransferase (SOAT) 1 or, in the case of hepatocytes and enterocytes, SOAT2...
  9. Wang S, Lin H, Lin Y, Chen Y, Pan Y, Tung C, et al. Embryonic cholesterol esterification is regulated by a cyclic AMP-dependent pathway in yolk sac membrane-derived endodermal epithelial cells. PLoS ONE. 2017;12:e0187560 pubmed publisher
    ..Because the major enzyme for yolk sac membrane cholesteryl ester synthesis is SOAT1, we cloned the avian SOAT1 promoter and elucidated the cellular functions of SOAT1...

More Information

Publications143 found, 100 shown here

  1. Lin H, Wang S, Pan Y, Ding S. Primary Endodermal Epithelial Cell Culture from the Yolk Sac Membrane of Japanese Quail Embryos. J Vis Exp. 2016;: pubmed publisher
    ..Utilizing the EECs, we demonstrated that the expression of SOAT1 was regulated by the cAMP dependent protein kinase A related pathway...
  2. Saadane A, Mast N, Dao T, Ahmad B, Pikuleva I. Retinal Hypercholesterolemia Triggers Cholesterol Accumulation and Esterification in Photoreceptor Cells. J Biol Chem. 2016;291:20427-39 pubmed publisher
    ..OS were also found to express the cholesterol-esterifying enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT1), but not lecithin-cholesterol acyltransferase (LCAT), and to differ from humans in retinal expression of ACAT1...
  3. Liao C, Liou A, Chang Y, Wu S, Chang C, Lee C, et al. Immunodeficient mouse models with different disease profiles by in vivo infection with the same clinical isolate of enterovirus 71. J Virol. 2014;88:12485-99 pubmed publisher
    ..developed limb paralysis and death at near-100% efficiency, the gamma interferon receptor knockout (ifngr KO) and stat-1 knockout mice exhibited paralysis and death rates near 78% and 30%, respectively...
  4. Chang N, Chan Y, Ding S, Lee Y, HuangFu W, Liu I. Sterol O-Acyltransferase 2 Contributes to the Yolk Cholesterol Trafficking during Zebrafish Embryogenesis. PLoS ONE. 2016;11:e0167644 pubmed publisher
    ..Soat) mediates the absorption and transportation of yolk lipids to the developing embryo, zebrafish soat1 and soat2 were cloned and studied...
  5. Parini P, Melhuish T, Wotton D, Larsson L, Ahmed O, Eriksson M, et al. Overexpression of transforming growth factor ? induced factor homeobox 1 represses NPC1L1 and lowers markers of intestinal cholesterol absorption. Atherosclerosis. 2018;275:246-255 pubmed publisher
    ..Villin-Tgif1 mice fed regular chow or a high-fat diet had lower levels of markers of intestinal cholesterol absorption than wild types. We suggest TGIF1 as a new player in intestinal cholesterol metabolism. ..
  6. Repa J, Buhman K, Farese R, Dietschy J, Turley S. ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis. Hepatology. 2004;40:1088-97 pubmed
    Acyl CoA:cholesterol acyltransferase (ACAT) 2 is the major cholesterol-esterifying enzyme in mouse enterocytes and hepatocytes. Male ACAT2(+/+) and ACAT2(-/ -) mice were fed chow containing added cholesterol (0%-0.500% w/w) for 24 days...
  7. Shen L, Zhu J, Chen F, Lin W, Cai J, Zhong J, et al. RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study. BMC Cancer. 2015;15:970 pubmed publisher
    ..tyrosine metabolism, drug metabolism, and PPAR pathway, but also suppressed transforming growth factor β, Jak-STAT, DNA replication, mismatch repair, p53 pathway, JNK signaling pathway, and nucleotide excision repair...
  8. Morey P, Pfannkuch L, Pang E, Boccellato F, Sigal M, Imai Matsushima A, et al. Helicobacter pylori Depletes Cholesterol in Gastric Glands to Prevent Interferon Gamma Signaling and Escape the Inflammatory Response. Gastroenterology. 2018;154:1391-1404.e9 pubmed publisher
    ..cells and cell lines, infection with H pylori, but not cgt mutants, blocked IFNG-induced signaling via JAK and STAT. Cells infected with H pylori were depleted of cholesterol, which reduced IFNG signaling by disrupting lipid rafts, ..
  9. Rognes K. Revision of the frog fly genus Caiusa Surcouf, 1920 (Diptera, Calliphoridae), with a note on the identity of Plinthomyia emimelania Rondani, 1875. Zootaxa. 2015;3952:1-80 pubmed publisher
    ..nov. (Thailand); Caiusa testacea Senior-White, 1923 (India, Nepal, Sri Lanka) and Caiusa violacea Séguy, 1925, stat. rev. (Cambodia, China, Laos, Malaysia, Taiwan, Thailand, Vietnam)...
  10. Potter C, Kern M, Baybo M, Pruett N, Godwin A, Sundberg J, et al. Dysregulated expression of sterol O-acyltransferase 1 (Soat1) in the hair shaft of Hoxc13 null mice. Exp Mol Pathol. 2015;99:441-4 pubmed publisher
    The cholesterol-metabolizing enzyme sterol O-acetyltransferase (SOAT1) is implicated in an increasing number of biological and pathological processes in a number of organ systems, including the differentiation of the hair shaft...
  11. Cha H, Ahn S, Cheon J, Park S, Kim K. Hataedock treatment has preventive therapeutic effects for atopic dermatitis through skin barrier protection in Dermatophagoides farinae-induced NC/Nga mice. J Ethnopharmacol. 2017;206:327-336 pubmed publisher
    ..01). The levels of interleukin-4 (IL-4), IL-13, signal transducer and activator of transcription-6 (STAT-6) and Cluster of differentiation 40 (CD40) were significantly reduced in the HTD treated group (p<0.01)...
  12. Watanabe T, Arita S, Shiraishi Y, Suguro T, Sakai T, Hongo S, et al. Human urotensin II promotes hypertension and atherosclerotic cardiovascular diseases. Curr Med Chem. 2009;16:550-63 pubmed
    ..Here, we summarize the key roles of U-II in progression of hypertension and atherosclerotic cardiovascular diseases. ..
  13. Ottani A, Neri L, Canalini F, Calevro A, Rossi R, Cappelli G, et al. Protective effects of the melanocortin analog NDP-α-MSH in rats undergoing cardiac arrest. Eur J Pharmacol. 2014;745:108-16 pubmed publisher
    ..kinases (JAK), extracellular signal-regulated kinases (ERK) and signal transducers and activators of transcription (STAT) signalings...
  14. De S, Manna A, Kundu S, De Sarkar S, Chatterjee U, Sen T, et al. Allylpyrocatechol Attenuates Collagen-Induced Arthritis via Attenuation of Oxidative Stress Secondary to Modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 Pathways. J Pharmacol Exp Ther. 2017;360:249-259 pubmed publisher
    ..Taken together, APC controlled the development of arthritis, possibly via modulation of signaling pathways, and deserves further consideration as a therapy for RA. ..
  15. Liu M, Li Y, Liang B, Li Z, Jiang Z, Chu C, et al. Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway. Int J Mol Med. 2018;41:1867-1876 pubmed publisher
    ..apoptosis in diabetic rats, by regulating the Janus kinase?signal transducer and activator of transcription (JAK?STAT) signaling pathway...
  16. Arora N, Shah K, Pandey Rai S. Inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some Indian medicinal plants. Protoplasma. 2016;253:503-15 pubmed publisher
    ..growth factor (TGF)-β, toll-like receptor (TLR)-2, signal transducer and activator of transcription (STAT-3), 15-lipoxygenase (LOX)-2, coiled-coil alpha-helical rod protein 1 (CCHCR1), steroidogenic acute regulatory ..
  17. Pedigo C, Ducasa G, Leclercq F, Sloan A, Mitrofanova A, Hashmi T, et al. Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury. J Clin Invest. 2016;126:3336-50 pubmed publisher
    ..ABCA1-mediated) cholesterol efflux and reduced cholesterol esterification by sterol-O-acyltransferase 1 (SOAT1)...
  18. Kaushansky A, Kaushansky K. Systems biology of megakaryocytes. Adv Exp Med Biol. 2014;844:59-84 pubmed publisher
    ..Among the best studied are the signal transducers and activators of transcription (STAT) proteins; phosphoinositol-3-kinase; mitogen-activated protein kinases; the phosphatases PTEN, SHP1, SHP2, and ..
  19. Yang J, Hwang Y, Gu M, Cho W, Ma J. Ethanol extracts of Sanguisorba officinalis L. suppress TNF-α/IFN-γ-induced pro-inflammatory chemokine production in HaCaT cells. Phytomedicine. 2015;22:1262-8 pubmed publisher
    ..ESOL also suppressed the phosphorylation of signal transducer and activator of transcription (STAT)-1, extracellular signal-regulated kinase (ERK), and inhibited both nuclear factor of kappa light polypeptide gene ..
  20. Moskalev A, Shaposhnikov M, Snezhkina A, Kogan V, Plyusnina E, Peregudova D, et al. Mining gene expression data for pollutants (dioxin, toluene, formaldehyde) and low dose of gamma-irradiation. PLoS ONE. 2014;9:e86051 pubmed publisher
    ..pathway, TGF-beta signaling pathway, proteasome, basal transcription factors, nucleotide excision repair, Jak-STAT signaling pathway, circadian rhythm, Hippo signaling pathway, mTOR signaling pathway, ribosome, mismatch repair, ..
  21. Narsale A, Enos R, Puppa M, Chatterjee S, Murphy E, Fayad R, et al. Liver inflammation and metabolic signaling in ApcMin/+ mice: the role of cachexia progression. PLoS ONE. 2015;10:e0119888 pubmed publisher
    ..immunoglobulin protein), IRE-1α (endoplasmic reticulum to nucleus signaling 1), and inflammatory intermediate STAT-3 (signal transducer and activator of transcription 3)...
  22. Wu P, Jiang W, Jiang J, Zhao J, Liu Y, Zhang Y, et al. Dietary choline deficiency and excess induced intestinal inflammation and alteration of intestinal tight junction protein transcription potentially by modulating NF-?B, STAT and p38 MAPK signaling molecules in juvenile Jian carp. Fish Shellfish Immunol. 2016;58:462-473 pubmed publisher
    ..kinase 2 in the MI and DI, nuclear factor kappa B (NF-?B), signal transducers and activators of transcription (STAT) 4 and STAT5 in the PI, MI and DI) of juvenile Jian carp, further indicating that choline deficiency caused ..
  23. Sárközy M, Szucs G, Fekete V, Pipicz M, Eder K, Gáspár R, et al. Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats. Cardiovasc Diabetol. 2016;15:110 pubmed publisher
    ..Protein-protein interaction analysis demonstrated that Stat is a potential key gene influenced by non-obese T2DM. Non-obese T2DM alters cardiac gene expression profile...
  24. Wang J, Chen S, Liao Y, Zhang E, Feng S, Yu S, et al. Mitogen-activated Protein Kinase Kinase 2 (MEK2), a Novel E2-interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway. J Virol. 2016;: pubmed
    ..after blocking the interferon-induced Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway by ruxolitinib, a JAK-STAT-specific inhibitor...
  25. Liu X, Lu H, Chen T, Nallaparaju K, Yan X, Tanaka S, et al. Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation. Cell Rep. 2016;14:1735-1747 pubmed publisher
    ..Tfh cell differentiation through antagonizing IL-7R (CD127)/signal transducer and activator of transcription (STAT) 5 axis; deletion of the Bcl6 gene in T cells resulted in enhanced IL-7R-STAT5 signaling and substantial expansion ..
  26. Zhang H, Zhai X. [Research advances in the role of JAK2 mutations in acute leukemia]. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17:644-9 pubmed
    The Janus kinase -signal transducer and activator of transcription (JAK-STAT) pathway plays pivotal roles in the regulation of cell proliferation, differentiation, migration and apoptosis, which is closely related with the development of ..
  27. Hou B, Jian Z, Cui P, Li S, Tian R, Ou J. miR-216a may inhibit pancreatic tumor growth by targeting JAK2. FEBS Lett. 2015;589:2224-32 pubmed publisher
    ..In conclusion, miR-216a may function as a tumor suppressor regulating pancreatic cancer cells by targeting the JAK/STAT pathway...
  28. Bryan J, Verstovsek S. Overcoming treatment challenges in myelofibrosis and polycythemia vera: the role of ruxolitinib. Cancer Chemother Pharmacol. 2016;77:1125-42 pubmed publisher
    ..neoplasms associated with somatic hematopoietic stem cell mutations leading to over activation of JAK-STAT signaling...
  29. Hansen M, Cai L, MONROE S, Li Z. Limited-information goodness-of-fit testing of diagnostic classification item response models. Br J Math Stat Psychol. 2016;69:225-252 pubmed publisher
    ..Educ. Behav. Stat., 22, 265) local dependence statistic XLD2 for characterizing sources of misfit, an important aspect of model ..
  30. Sun Y, Lin X, Li L. Identification of Biomarkers for Schistosoma-Associated Pulmonary Arterial Hypertension Based on RNA-Seq Data of Mouse Whole Lung Tissues. Lung. 2017;195:377-385 pubmed publisher
    ..cell lineage (degree = 20), chemokine signaling pathway (degree = 18), and JAK-STAT signaling pathway (degree = 18)...
  31. Ben Ayed S, Ali M, Bali A, Gargouri Y, Laouini D, Ben Ali Y. Secretory lipase from the human pathogen Leishmania major: Heterologous expression in the yeast Pichia pastoris and biochemical characterization. Biochimie. 2018;146:119-126 pubmed publisher
    ..Optimal Lmlip2 lipase activity was measured using the pH stat technique at pH 8?at 26?°C using vinyl esters and triacylglycerols (true lipids) as substrates...
  32. Miklossy G, Youn U, Yue P, Zhang M, Chen C, Hilliard T, et al. Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin ?-2 Expression, and Induce Antitumor Effects against Human Glioma. J Med Chem. 2015;58:7734-48 pubmed publisher
    ..analogues, 30, 31, 33, and 36, inhibit constitutively active signal transducer and activator of transcription (Stat)3 and malignant glioma phenotype. A position 13 lipophilic ester group is required for activity...
  33. Zhang X, You Q, Zhang X, Chen X. SOCS3 Methylation Predicts a Poor Prognosis in HBV Infection-Related Hepatocellular Carcinoma. Int J Mol Sci. 2015;16:22662-75 pubmed publisher
    Suppressor of cytokine signaling 3 (SOCS3) plays crucial roles in JAK/STAT signaling pathway inhibition in hepatocellular carcinoma (HCC)...
  34. Al Jamal H, Mat Jusoh S, Hassan R, Johan M. Enhancing SHP-1 expression with 5-azacytidine may inhibit STAT3 activation and confer sensitivity in lestaurtinib (CEP-701)-resistant FLT3-ITD positive acute myeloid leukemia. BMC Cancer. 2015;15:869 pubmed publisher
    ..Src homology-2 (SH2)-containing protein-tyrosine phosphatase 1 (SHP-1) is a negative regulator of the JAK/STAT pathway...
  35. Fernandes A, Pedroso R, de Mello T, Donatti L, Venazzi E, Demarchi I, et al. In vitro characterization of Leishmania (Viannia) braziliensis isolates from patients with different responses to Glucantime(®) treatment from Northwest Paraná, Brazil. Exp Parasitol. 2016;167:83-93 pubmed publisher
    ..medium and different grow phases were analyzed, MID-Logarithimic (Mid-LOG), Logarithimic (LOG) and Stationary (STAT) phases. Complement resistance was evaluated using guinea pig serum...
  36. Pahari S, Khan N, Aqdas M, Negi S, Kaur J, Agrewala J. Infergen Stimulated Macrophages Restrict Mycobacterium tuberculosis Growth by Autophagy and Release of Nitric Oxide. Sci Rep. 2016;6:39492 pubmed publisher
    ..was different from the type-1 interferons; since it worked through the activation of NF-?B, phosphorylation of STAT-3 and Akt-PI3K that improved the bactericidal activity through autophagy and NO release...
  37. Maddux N, Daniels A, Randolph T. Microflow Imaging Analyses Reflect Mechanisms of Aggregate Formation: Comparing Protein Particle Data Sets Using the Kullback-Leibler Divergence. J Pharm Sci. 2017;106:1239-1248 pubmed publisher
    ..1951. Ann Math Stat. 22:79-86)...
  38. Kong D, Wang Y. Knockdown of lncRNA HULC inhibits proliferation, migration, invasion, and promotes apoptosis by sponging miR-122 in osteosarcoma. J Cell Biochem. 2018;119:1050-1061 pubmed publisher
    ..Furthermore, overexpression of miR-122 inactivated PI3K/AKT, JAK/STAT, and Notch pathways by downregulation of HNF4G...
  39. Zhang J, Yin S, Yi D, Zhang H, Li Z, Guo F, et al. The Brucella melitensis M5-90?manB live vaccine candidate is safer than M5-90 and confers protection against wild-type challenge in BALB/c mice. Microb Pathog. 2017;112:148-155 pubmed publisher
    ..goats inoculated with M5-90?manB were negative by Bengal Plate Test (RBPT) and Standard Tube Agglutination Test (STAT)...
  40. Ermilov S, Bayartogtokh B. Systematic placement of some taxa in the family Galumnidae (Acari, Oribatida). Zootaxa. 2015;3964:489-93 pubmed publisher
    ..proposed, resulting in the following taxonomic proposals: Pergalumna (Bigalumna) Mahunka & Mahunka-Papp, 2009 stat. nov., P. (B.) rimosa (Mahunka & Mahunka-Papp, 2009) comb. nov...
  41. Wu X, Li X, Li Y, Kong L, Fang J, Zhou X, et al. The overexpression of Thioredoxin-1 suppressing inflammation induced by methamphetamine in spleen. Drug Alcohol Depend. 2016;159:66-71 pubmed publisher
    ..interferon-γ(IFN-γ), interleukin-2 (IL-2), T-bet and signal transducer and activators of transcription 4 (STAT 4) were increased and the mRNA levels of IL-10, GA-TA-binding protein-3 (GATA-3) and STAT 6 were decreased...
  42. Harding K, Watts J, Karimi L, O Reilly M, Kent B, Kotis M, et al. Improving access for community health and sub-acute outpatient services: protocol for a stepped wedge cluster randomised controlled trial. BMC Health Serv Res. 2016;16:364 pubmed publisher
    ..from two controlled studies indicates that an alternative to the traditional "waitlist and triage" model known as STAT (Specific Timely Appointments for Triage) may be successful in reducing waiting times without adversely affecting ..
  43. Kobayashi K, Ohshiro T, Tomoda H, Yin F, Cui H, Chouthaiwale P, et al. Discovery of SOAT2 inhibitors from synthetic small molecules. Bioorg Med Chem Lett. 2016;26:5899-5901 pubmed publisher
    ..derivatives and related molecules were screened for inhibition of sterol O-acyltransferase (SOAT) isozymes SOAT1 and SOAT2...
  44. Eletto D, Burns S, Angulo I, Plagnol V, Gilmour K, Henriquez F, et al. Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection. Nat Commun. 2016;7:13992 pubmed publisher
    ..Cells from this patient exhibit reduced JAK1 and STAT phosphorylation following cytokine stimulations, reduced induction of expression of interferon-regulated genes and ..
  45. Dai J, Fang P, Saredy J, Xi H, Ramon C, Yang W, et al. Metabolism-associated danger signal-induced immune response and reverse immune checkpoint-activated CD40+ monocyte differentiation. J Hematol Oncol. 2017;10:141 pubmed publisher
    ..metabolic RF-induced two-way stimulatory immune checkpoint amplification and discussed potential signaling pathways including AP-1, NF-κB, NFAT, STAT, and DNA methylation and their contribution to systemic and tissue inflammation.
  46. Zhao C, Liu Q, Wang K. Artesunate attenuates ACLT-induced osteoarthritis by suppressing osteoclastogenesis and aberrant angiogenesis. Biomed Pharmacother. 2017;96:410-416 pubmed publisher
    ..response and inhibited the activation of Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) signaling in ACLT rats...
  47. Presnell S, Chan H, Zhang L, Lutz C. IL-2/IL-15 activate the human clonally restricted KIR3DL1 reverse promoter. Genes Immun. 2013;14:107-14 pubmed publisher
    ..investigation of the KIR3DL1 reverse promoter showed significant differences from the forward promoter, with STAT and YY1 sites having relatively greater roles in regulating reverse proximal promoter activity...
  48. Di Lullo G, Marcatti M, Heltai S, Brunetto E, Tresoldi C, Bondanza A, et al. Th22 cells increase in poor prognosis multiple myeloma and promote tumor cell growth and survival. Oncoimmunology. 2015;4:e1005460 pubmed
    ..A fraction of MM cell lines and primary tumors aberrantly expressed the IL-22RA1 and IL-22 induced STAT-3 phosphorylation, cell growth, and resistance to drug-induced cell death in MM cells...
  49. Tomaszewska W, Szawaryn K. Epilachnini (Coleoptera: Coccinellidae)-A Revision of the World Genera. J Insect Sci. 2016;16: pubmed publisher
    ..The subgenus Cleta of Epilachna is raised to the genus level, as Cleta Mulsant 1850 stat. nov...
  50. Truong A, Rengaraj D, Hong Y, Hoang C, Hong Y, Lillehoj H. Differentially expressed JAK-STAT signaling pathway genes and target microRNAs in the spleen of necrotic enteritis-afflicted chicken lines. Res Vet Sci. 2017;115:235-243 pubmed publisher
    The JAK signal transducer and STAT signaling pathway is an important regulator of cell proliferation, differentiation, survival, motility, apoptosis, immune response, and development...
  51. Sawyer J, Cohen E, Fox D. Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone. Development. 2017;144:4091-4102 pubmed publisher
    ..of unpaired-3 cytokine, which signals through a Signal transducer and activator of transcription (STAT) protein to promote cell division only in OB-ISCs...
  52. Jin C, Peng X, Liu F, Cheng L, Xie T, Lu X, et al. Interferon-induced sterile alpha motif and histidine/aspartic acid domain-containing protein 1 expression in astrocytes and microglia is mediated by microRNA-181a. AIDS. 2016;30:2053-64 pubmed publisher
    ..interferons induce SAMHD1 expression through Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathways, which is mediated by miR-181a...
  53. Gowen B, Westover J, Miao J, Van Wettere A, Rigas J, Hickerson B, et al. Modeling Severe Fever with Thrombocytopenia Syndrome Virus Infection in Golden Syrian Hamsters: Importance of STAT2 in Preventing Disease and Effective Treatment with Favipiravir. J Virol. 2017;91: pubmed publisher
    ..There is evidence that in human cells, SFTSV sequesters STAT proteins in replication complexes, thereby inhibiting type I interferon signaling...
  54. Góes Junior A, Abib S, Alves M, Ferreira P, Andrade M. Venous Shunt Versus Venous Ligation for Vascular Damage Control: The Immunohistochemical Evidence. Ann Vasc Surg. 2017;41:214-224 pubmed publisher
    ..Transonic Systems flowmeters were used to measure vascular flow on right and left external iliac vessels, and i-STAT (Abbot) portable blood analyzer was used for EIVs blood biochemical analysis...
  55. Ng Kuet Leong N, Brombacher F, Dalpke A, Weitnauer M. Crosstalk between glucocorticoids and IL-4 modulates Ym1 expression in alternatively activated myeloid cells. Immunobiology. 2017;222:759-767 pubmed publisher
    ..Further analysis identified overlapping but functionally active glucocorticoid receptor and STAT-6 binding sites, supporting the cooperative effect of glucocorticoids and IL-4 in the regulation of Ym1...
  56. Kanamori Y, Murakami M, Sugiyama M, Hashimoto O, Matsui T, Funaba M. Interleukin-1? (IL-1?) transcriptionally activates hepcidin by inducing CCAAT enhancer-binding protein ? (C/EBP?) expression in hepatocytes. J Biol Chem. 2017;292:10275-10287 pubmed publisher
    ..elements (BMP-REs) 1 and 2 as well as the signal transducer and activator of transcription 3-binding site (STAT-BS)...
  57. Giotis E, Ross C, Robey R, Nohturfft A, Goodbourn S, Skinner M. Constitutively elevated levels of SOCS1 suppress innate responses in DF-1 immortalised chicken fibroblast cells. Sci Rep. 2017;7:17485 pubmed publisher
    ..mammals, interacts with an E3 ubiquitin ligase complex) is not essential for the inhibition of cytokine-induced JAK/STAT signalling activation in DF-1...
  58. Guo Z, Lin S, Heinen J, Chang C, Chang T. The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain. J Biol Chem. 2005;280:37814-26 pubmed
    ..within the region of amino acids 354-493, expressed these mutants in Chinese hamster ovary cells lacking ACAT1, and prepared microsomes from transfected cells...
  59. Lin Q, Chauvistré H, Costa I, Gusmao E, Mitzka S, Hänzelmann S, et al. Epigenetic program and transcription factor circuitry of dendritic cell development. Nucleic Acids Res. 2015;43:9680-93 pubmed publisher
    ..the transcription factor hierarchy that drives the sequel MPP-CDP-cDC/pDC, including Irf4, Irf8, Tcf4, Spib and Stat factors...
  60. Ferraris P, Chandra P, Panigrahi R, Aboulnasr F, Chava S, Kurt R, et al. Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression. Am J Pathol. 2016;186:938-51 pubmed publisher
    ..higher levels of IFN-λ proteins (IL28B, IL-29), preactivated IFN-stimulated gene (ISG) expression, and impaired Stat phosphorylation when stimulated with either IFN-α or IFN-λ1...
  61. de Araujo E, Manaswiyoungkul P, Israelian J, Park J, Yuen K, Farhangi S, et al. High-throughput thermofluor-based assays for inhibitor screening of STAT SH2 domains. J Pharm Biomed Anal. 2017;143:159-167 pubmed publisher
    The development of STAT protein-specific inhibitors has been the focus of a number of drug discovery programs...
  62. Pérez Pérez A, Guadix P, Maymó J, Dueñas J, Varone C, Fernández Sánchez M, et al. Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects. Horm Metab Res. 2016;48:62-9 pubmed publisher
    Insulin and leptin receptors are known to share signaling pathways, such as JAK2/STAT-3 (Janus kinase2/signal transduction and activator of transcription3), MAPK (Mitogen activated protein kinase), and PI3K (phosphoinositide 3-kinase)...
  63. Adachi K, Trendafilov N. Some Mathematical Properties of the Matrix Decomposition Solution in Factor Analysis. Psychometrika. 2018;83:407-424 pubmed publisher
    ..have been developed and some properties have been discussed in the literature (notably by Stegeman in Comput Stat Data Anal 99:189-203, 2016), but, as a whole, MDFA has not been studied fully yet...
  64. Kanturski M, Kajtoch Ł, Wieczorek K. European species of the aphid genus <i>Eulachnus</i> Del Guercio, 1909 (Hemiptera: Aphididae: Lachninae): revision and molecular phylogeny. Zootaxa. 2017;4356:1-81 pubmed publisher
    ..nigrofasciatus (near C. brauni) are regarded as incertae sedis. Full species status is given for E. garganicus stat. nov. and E. ibericus stat. nov. Apterous viviparous female of E...
  65. Saad A, Abushouk A, Al Husseini M, Salahia S, Alrefai A, Afifi A, et al. Characteristics, survival and incidence rates and trends of primary cardiac malignancies in the United States. Cardiovasc Pathol. 2018;33:27-31 pubmed publisher
    ..We used SEER*Stat (version 8.3.4) and the National Cancer Institute's Joinpoint Regression software (version 4.5.0...
  66. Faberova V, Schmidtová L, Bednarikova M, Drimal J, Drimal D. The ACAT inhibitor VULM1457 significantly reduced production and secretion of adrenomedullin (AM) and down-regulated AM receptors on human hepatoblastic cells. Gen Physiol Biophys. 2005;24:397-409 pubmed
    Acyl-CoA:cholesterol acyltransferase (ACAT) is an important enzyme in the pathways of cholesterol esterification...
  67. Ren J, Wang L, Zhao J, Wang L, Ning S, El Gazzar M, et al. Decline of miR-124 in myeloid cells promotes regulatory T-cell development in hepatitis C virus infection. Immunology. 2017;150:213-220 pubmed publisher
    ..suggested that miR-124 may be involved in the regulation of signal transducer and activator of transcription 3 (STAT-3), which was overexpressed in MDSCs from HCV patients...
  68. Fominykh D, Zamotajlov A, Titarenko A. Further contribution to the knowledge of Georgian species of the Carabus Linnaeus, 1758 subgenus Neoplectes Reitter, 1885, with description of a new subspecies of C. titarenkoi Zamotajlov & Fominykh, 2014 (Coleoptera: Carabidae: Carabini). Zootaxa. 2016;4179:561-599 pubmed publisher
    ..C. (Neoplectes) mellyi boulbenorum Deuve, 2015 is synonymized with the nomynotypical subspecies. A new status of the subspecies Carabus (Neoplectes) lafertei montreuilianus Deuve, 2014, stat. nov. is also proposed.
  69. Quan Y, Xu H, Han Y, Mesplède T, Wainberg M. JAK-STAT Signaling Pathways and Inhibitors Affect Reversion of Envelope-Mutated HIV-1. J Virol. 2017;91: pubmed publisher
    ..However, the activation of JAK-STAT signaling pathways caused the inhibition of such cell-to-cell infection as well as the reversion of multiple HIV ..
  70. Ashino S, Takeda K, Li H, Taylor V, Joetham A, Pine P, et al. Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses. J Allergy Clin Immunol. 2014;133:1162-74 pubmed publisher
    ..TH1 or TH17 cells, which was associated with downregulation of signal transducer and activator of transcription (STAT) 6 and STAT5 phosphorylation. However, once polarized, TH2 cells were unaffected by the inhibitor...
  71. Wang Y, Wan M, Zhou Q, Wang H, Wang Z, Zhong X, et al. The Prognostic Role of SOCS3 and A20 in Human Cholangiocarcinoma. PLoS ONE. 2015;10:e0141165 pubmed publisher
    As an antagonist of the JAK/STAT pathway, suppressor of cytokine signaling 3 (SOCS3) plays an integral role in shaping the inflammatory environment, tumorigenesis and disease progression in cholangiocarcinoma (CCA); however, its ..
  72. Floss D, Klöcker T, Schröder J, Lamertz L, Mrotzek S, Strobl B, et al. Defining the functional binding sites of interleukin 12 receptor ?1 and interleukin 23 receptor to Janus kinases. Mol Biol Cell. 2016;27:2301-16 pubmed publisher
    ..with IL-12 and IL-23 results in activation of receptor-associated Janus kinases (Jak) and phosphorylation of STAT proteins in target cells...
  73. Luo K. Signaling Cross Talk between TGF-?/Smad and Other Signaling Pathways. Cold Spring Harb Perspect Biol. 2017;9: pubmed publisher
    ..of Wnt, Notch, Hippo, Hedgehog (Hh), mitogen-activated protein (MAP), kinase, phosphoinositide 3-kinase (PI3K)-Akt, nuclear factor ?B (NF-?B), and Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways.
  74. Zhu R, Du H, Li S, Li Y, Ni H, Yu X, et al. De novo annotation of the immune-enriched transcriptome provides insights into immune system genes of Chinese sturgeon (Acipenser sinensis). Fish Shellfish Immunol. 2016;55:699-716 pubmed publisher
    ..known immune pathways from mammals and teleosts, such as pattern recognition receptor (PRR) signaling pathway, JAK-STAT signaling pathway, complement and coagulation pathway, T-cell receptor (TCR) and B-cell receptor (BCR) signaling ..
  75. Ambrozova G, Fidlerova T, Verescakova H, Koudelka A, Rudolph T, Woodcock S, et al. Nitro-oleic acid inhibits vascular endothelial inflammatory responses and the endothelial-mesenchymal transition. Biochim Biophys Acta. 2016;1860:2428-2437 pubmed publisher
    ..and ECs by reducing pro-inflammatory cytokine production and adhesion molecule expression through its modulation of STAT, MAPK and NF-?B-regulated signaling...
  76. Vannucchi A. From leeches to personalized medicine: evolving concepts in the management of polycythemia vera. Haematologica. 2017;102:18-29 pubmed publisher
    ..The landmark discovery of the autonomously activated JAK/STAT signaling pathway paved the way for the clinical development of the first target drug, the JAK1 and JAK2 inhibitor ..
  77. Gropen T, Boehme A, Martin Schild S, Albright K, Samai A, Pishanidar S, et al. Derivation and Validation of the Emergency Medical Stroke Assessment and Comparison of Large Vessel Occlusion Scales. J Stroke Cerebrovasc Dis. 2018;27:806-815 pubmed publisher
    ..We compared the EMSA with the 3-item stroke scale (3I-SS), Cincinnati Prehospital Stroke Severity Scale (C-STAT), Rapid Arterial oCclusion Evaluation (RACE) scale, and Field Assessment Stroke Triage for Emergency Destination (..
  78. Zhu X, Wang D, Zhou J, Pan T, Chen J, Yang Y, et al. Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2. J Virol. 2017;91: pubmed publisher
    ..1 (JAK1), tyrosine kinase 2 (TYK2), STAT1, and interferon regulatory factor 9 (IRF9), key molecules of the JAK-STAT pathway. STAT2 cleavage was dependent on the protease activity of nsp5...
  79. Leehy K, Truong T, Mauro L, Lange C. Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models. J Steroid Biochem Mol Biol. 2018;176:88-93 pubmed publisher
    ..Components of these PR/PRL signaling pathways could offer alternative drug targets and logical complements to anti-ER or anti-estrogen-based endocrine therapies. ..
  80. Lorenzini T, Dotta L, Giacomelli M, Vairo D, Badolato R. STAT mutations as program switchers: turning primary immunodeficiencies into autoimmune diseases. J Leukoc Biol. 2017;101:29-38 pubmed publisher
    b>STAT proteins are a family of transcription factors that mediate cellular response to cytokines and growth factors...
  81. Girardi T, Vereecke S, Sulima S, Khan Y, Fancello L, Briggs J, et al. The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling. Leukemia. 2017;: pubmed publisher
    ..The JAK-STAT signaling pathway is a critical controller of cellular proliferation and survival...
  82. Bebe A, Nielsen A, Willadsen T, Søndergaard J, Siersma V, Nicolaisdóttir D, et al. Exploring the concurrent validity of the nationwide assessment of permanent nursing home residence in Denmark - A cross-sectional data analysis using two administrative registries. BMC Health Serv Res. 2017;17:607 pubmed publisher
    ..Within each Danish Region, we randomly selected one municipality reporting to Stat D (Method 1) and one not reporting where instead an algorithm created by StatD was used to discover nursing home ..
  83. Shibuya K, Watanabe T, Urano Y, Takabe W, Noguchi N, Kitagishi H. Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death. Bioorg Med Chem. 2016;24:2559-66 pubmed publisher
    ..esters, which are involved in neuronal cell death, through catalysis with acyl-CoA:cholesterol acyltransferase-1 (ACAT-1). We studied the regioselectivity of the acylation of the secondary alcohol at the 3- or 24-position of 24S-OHC...
  84. La Fortezza M, Schenk M, Cosolo A, Kolybaba A, Grass I, Classen A. JAK/STAT signalling mediates cell survival in response to tissue stress. Development. 2016;143:2907-19 pubmed publisher
    ..Signalling through the Janus kinase/Signal transducers and activators of transcription (JAK/STAT) pathway, which is a potential JNK target, is implicated in promoting compensatory proliferation...
  85. Bakhaus K, Bennien J, Fietz D, Sánchez Guijo A, Hartmann M, Serafini R, et al. Sodium-dependent organic anion transporter (Slc10a6-/-) knockout mice show normal spermatogenesis and reproduction, but elevated serum levels for cholesterol sulfate. J Steroid Biochem Mol Biol. 2018;179:45-54 pubmed publisher
    The sodium-dependent organic anion transporter SOAT (gene name SLC10A6 in man and Slc10a6 in mice) is a plasma membrane transporter for sulfated steroids, which is highly expressed in germ cells of the testis...
  86. Lu J, Xu D, Jiang Y, Kong S, Shen Z, Xia S, et al. Integrated analysis of mRNA and viral miRNAs in the kidney of Carassius auratus gibelio response to cyprinid herpesvirus 2. Sci Rep. 2017;7:13787 pubmed publisher
    ..miRNAs-mRNA pairs revealed diverse affected immune signalling pathways, including the RIG-I-like receptor and JAK-STAT pathways...
  87. Stickel N, Hanke K, Marschner D, Prinz G, Kohler M, Melchinger W, et al. MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT signaling in dendritic cells after stem cell transplantation. Leukemia. 2017;31:2732-2741 pubmed publisher
    ..that miR-146a acts as a central regulator of recipient-type DC activation during GVHD by dampening the pro-inflammatory JAK-STAT/CIITA/MHCII axis, which provides a scientific rationale for early JAK1/2 inhibition in selected patients.
  88. Alberdi P, Espinosa P, Cabezas Cruz A, De La Fuente J. Anaplasma phagocytophilum Manipulates Host Cell Apoptosis by Different Mechanisms to Establish Infection. Vet Sci. 2016;3: pubmed publisher
    ..pathogen inhibits apoptosis through the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway, while in salivary glands, the intrinsic apoptosis pathways is inhibited but tick cells respond with the ..
  89. Silva D, Skejo J, Pereira M, Domenico F, Sperber C. Comments on the recent changes in taxonomy of pygmy unicorns, with description of a new species of Metopomystrum from Brazil (Insecta, Tetrigidae, Cleostratini, Miriatrini). Zookeys. 2017;:1-18 pubmed publisher
    ..Miriatrini stat. resurr. are monotypic and include only Miriatra, Cleostratini are monotypic as well...
  90. Chen L, Yao Q, Xu S, Wang H, Qu P. Inhibition of the NLRP3 inflammasome attenuates foam cell formation of THP-1 macrophages by suppressing ox-LDL uptake and promoting cholesterol efflux. Biochem Biophys Res Commun. 2018;495:382-387 pubmed publisher
  91. Hori M, Miyazaki A, Tamagawa H, Satoh M, Furukawa K, Hakamata H, et al. Up-regulation of acyl-coenzyme A:cholesterol acyltransferase-1 by transforming growth factor-beta1 during differentiation of human monocytes into macrophages. Biochem Biophys Res Commun. 2004;320:501-5 pubmed
    Expression of acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) increases during differentiation of human monocytes into macrophages...
  92. Banisch T, Maimon I, Dadosh T, Gilboa L. Escort cells generate a dynamic compartment for germline stem cell differentiation via combined Stat and Erk signalling. Development. 2017;144:1937-1947 pubmed publisher
    ..We further show that Signal Transducer and Activator of Transcription (Stat) and Epidermal Growth Factor Receptor (Egfr) signalling sustain EC protrusiveness and flexibility by ..